ライフサイエンスコーパス: gene copy number

1 ellular components such as enzyme levels and gene-copy numbers).

2 hanges that correspond to protein levels and gene copy number.

3 smodium codon bias is not correlated to tRNA gene copy number.

4 reby generating haplotypes with variation in gene copy number.

5 of 134 isolates correlated with plasmepsin 2 gene copy number.

6 by allelic differences in catalytic rate and gene copy number.

7 in lysate array, was tightly correlated with gene copy number.

8 ing Rht-D1b allele, caused by an increase in gene copy number.

9 FR) protein expression and/or with high EGFR gene copy number.

10 omplished, at least in part, through altered gene copy number.

11 and Gossypioides kirkii was correlated with gene copy number.

12 the liver tumor transcriptome was changes in gene copy number.

13 e of a complex genomic region that varies in gene copy number.

14 w lower-than-expected expression compared to gene copy number.

15 ot analysis was used to determine the rNKp30 gene copy number.

16 adjusted for the covariates of age and MYCN gene copy number.

17 content and amyloid precursor protein (APP) gene copy number.

18 hore production and that this was not due to gene copy number.

19 showed large increases in bacterial 16S rRNA gene copy number.

20 for SLE risk associated with reduced FCGR3B gene copy number.

21 t produces local rearrangements with altered gene copy numbers.

22 tio of telomere repeat copy number to single gene copy number 0.23, 0.09-0.59, p=0.002).

23 rity of gefitinib in patients with high EGFR-gene-copy number (85 vs 89 patients) was not proven (72

24 mia-initiating cells have uncovered multiple gene copy number aberrations and have yielded new insigh

25 d the clinicopathological relevance of SPAG5 gene copy number aberrations, mRNA transcript expression

26 tion protocol to calculate the relative TLR7 gene copy number according to the comparative 2(-DeltaDe

27 Comparison of the relative gene copy numbers according to the presence or absence o

28 Increased gene copy numbers after induction correlated with increa

29 types can lead to increases or decreases in gene copy number along chromosomes.

30 Human gene copy number alteration data, microarray expression

31 gnostic value of frequently detected somatic gene copy number alterations (CNAs) in mantle cell lymph

32 In a screen for gene copy number alterations in mouse mammary tumors ini

33 is are highly similar at the level of global gene copy number alterations, loss of heterozygosity and

34 er (LA-HNC) and correlate outcomes with EGFR gene copy number alterations.

35 This study reveals how rapid bouts of gene copy number amplification during accrual of distant

36 tumor suppressors, for example, by altering gene copy number amplitude.

37 s cancer, we used whole-exome sequencing and gene copy number analyses to study 32 primary tumors.

38 EGFR and K-ras mutation analyses and EGFR gene copy number analyses were performed on DNA from pre

39 Using laser capture microdissection and gene copy number analyses, we found that the frequency o

40 Here we perform gene copy number analysis (n=54), genome/exome (n=44) an

41 atory strategies and adaptive potential when gene copy number and allelic frequency are no longer con

42 vating mutations of the EGFR gene, increased gene copy number and certain clinical and pathological f

43 hypermethylation is associated with reduced gene copy number and chromosome 17 aneusomy as observed

44 Mucorales, and the correlation between CotH gene copy number and clinical prevalence, are consistent

45 In this study, we investigated gene copy number and CpG methylation status in CRPC to g

46 cells showed a significant increase in HER-2 gene copy number and expression.

47 re must necessarily be a correlation between gene copy number and gene expression level (transcript a

48 IIalpha (TOP2A) is commonly altered at both gene copy number and gene expression level in cancer cel

49 of these genes show good correlation between gene copy number and gene expression, and are thought to

50 ir data revealed a tight correlation between gene copy number and gene expression.

51 mprove our understanding of the evolution of gene copy number and gene structure.

52 ation, strain background, integration locus, gene copy number and intermodule compatibility.

53 els of gene silencing depended upon the RNAi gene copy number and its site of integration.

54 s constitutive expression, due to changes in gene copy number and local sequence effects, and that th

55 The linear correlation between sxtA1 gene copy number and microalgal abundance and between th

56 ficacy with epidermal growth factor receptor gene copy number and other biomarkers.

57 ave elevated Akt3 signaling due to increased gene copy number and PTEN loss.

58 No association was found between HER2 gene copy number and response (n = 39 patients) or survi

59 reported that this tight correlation between gene copy number and RNA levels is not observed in recen

60 rend for an association between the relative gene copy number and the autoantibody profile in SLE pat

61 order to study the relationship between Rai1 gene copy number and the Dp(11)17/+ phenotypes.

62 rmine the relationship between mitochondrial gene copy number and transcript abundance in the elongat

63 ers, particularly those corresponding to the gene copy number and transcription rate, cannot be disti

64 telomere maintenance and elongation but that gene copy number and transcriptional regulation of TR, b

65 ynonymous codon bias is correlated with tRNA gene copy number and with protein expression level in tr

66 s a means of achieving regulatory control of gene copy number and/or transcription.

67 gene loss and rearrangements further affect gene copy numbers and fractionate ancestral gene linkage

68 igital array enables accurate measurement of gene copy numbers and is of significant value in CNV stu

69 s of Metallosphaera yellowstonensis 16S rRNA gene copy numbers and mRNA expression of haem Cu oxidase

70 ter understanding of how polysomy 17 affects gene-copy number and protein expression will help to sel

71 Integration effects of transgene insertion, gene copy number, and expression variation, as well as d

72 SCC with prominent overexpression, increased gene copy number, and mutations.

73 s with gender, age, response to vaccination, gene copy number, and oral health.

74 d 1,179 controls) for total C4, C4A, and C4B gene copy numbers, and the loss-of-function C4 exon 29 C

75 not previously studied in RM system control--gene copy number--and of a hysteretic response.

76 large differences in gene family content and gene copy number are seen among the sequenced genomes.

77 ific fashion: The regular, discrete jumps in gene-copy number arising from DNA replication during the

78 that modulating HuD expression affects N-myc gene copy number as well as expression.

79 sequencing of the tyrosine kinase domain and gene copy number assessments were performed.

80 Increased EGFR gene copy number based on FISH analysis is demonstrated

81 depth among genes, indicating differences in gene copy number between genomes.

82 nt PC3 prostate cancer cells with high ANXA7 gene copy number, but not in PrEC.

83 High EGFR gene copy number by FISH is frequent in HNSCC and is a p

84 uded epidermal growth factor receptor (EGFR) gene copy number by fluorescence in situ hybridization (

85 We assessed PIK3CA gene copy number by fluorescence in situ hybridization a

86 sion by immunohistochemistry (IHC), and EGFR gene copy number by fluorescent in situ hybridization (F

87 enotyped using Sequenom MassArray and pfmdr1 gene copy number by real-time PCR.

88 situ hybridization (FISH) to determine EGFR gene copy number, by polymerase chain reaction and direc

89 is increasing evidence that the variation in gene copy number can give rise to substantial phenotypic

90 nism of dosage compensation, at the level of gene copy number, can occur when HTA1-HTB1 is deleted.

91 These effects were not due to differences in gene copy number, caused by partially replicated genomes

92 wever, we know little about why the abnormal gene copy number causes disease or why specific features

93 Comparing gene copy number change and RNA expression changes profi

94 ected very little consistent contribution of gene copy number change to RNA expression changes.

95 We compared gene copy number changes in the tumors based on histolog

96 The process of adaptation relies on gene copy number changes that arise at high rates, inclu

97 We identified 41 miRNA genes with gene copy number changes that were shared among the thre

98 that re-replication may be a contributor to gene copy number changes, which are important in fields

99 s exhibit one of three 'signatures' based on gene copy number changes.

100 tumor DNA and increase our ability to detect gene copy number changes.

101 n diseases, we will end with a discussion of gene copy-number changes as therapeutic targets.

102 In a screen for gene copy-number changes in mouse mammary tumors, we ide

103 mulation lines of Caenorhabditis elegans for gene copy-number changes with array comparative genomic

104 stigated the potential relationships between gene copy number (CN) alterations and DNA methylation pr

105 cus which undergo CNV, and to determine FCGR gene copy number (CN).

106 components are of unknown function, but low gene copy numbers combined with small genomes make proti

107 al amplifications often cause an increase in gene copy number, contributing to the pathogenesis of ca

108 The SMN2 gene copy number correlated inversely with the SMA pheno

109 eas neither EGFR protein/mRNA expression nor gene copy number correlated with cetuximab response, exa

110 Increased EGFR gene copy number correlated with LOH-positive status (P

111 Gene copy number correlated with protein expression (r =

112 determined by the HER2/CEP17 ratio and HER2 gene copy number could significantly predict some benefi

113 The remarkable variability in defensin gene copy numbers could contribute to differences in ind

114 rowth factor receptor (EGFR), increased EGFR gene copy number, cyclin D1 polymorphisms, specific gene

115 to more reliably interpret NGS-based cancer gene copy number data in the context of clinical sequenc

116 improved accuracy, relative to unstructured gene copy number data, at predicting tumor state and fut

117 Using this strategy, we integrated gene copy number data, drug exposure data and patient su

118 models of tumor progression from single-cell gene copy number data, including variable rates for diff

119 Mitochondrial gene copy number decreased from 3 to 8-DPA in the develo

120 siderably increases N-myc expression whereas gene copy number decreases.

121 ce increases in direct proportion to the GFP gene copy number delivered to cells by a replication-def

122 ndent, additive contributions to Flu(R) in a gene copy number-dependent manner that was not different

123 Increased EGFR gene copy number detected by FISH is associated with imp

124 Epidermal growth factor receptor (EGFR) gene copy number detected by fluorescent in situ hybridi

125 main mutations were not identified, and EGFR gene copy number did not relate to response or PFS, but

126 Additionally, as 16S rRNA gene copy numbers did not provide accurate model fits in

127 progenitor D genome seem to experience more gene copy number divergence than genes from the A genome

128 icularly important in cancer are measures of gene copy number DNA methylation.

129 elongation stages, is a mechanism to change gene copy number during differentiation.

130 ng cancer cell lines for alterations in EGFR gene copy number, enhanced expression of EGFR and other

131 d segmental duplication maps and genome-wide gene copy number estimates, we enable future CNV studies

132 ip between maternal tissue expansion and bcd gene copy number expansion in the ovary.

133 gene duplication is a prominent mechanism of gene copy number expansion.

134 Gene copy number, F.IX transcript levels in the liver, i

135 We determined beta-defensin gene copy number for 1002 Ethiopian and Tanzanian patien

136 Further, small changes in gene copy number for a 3-gene motif with successive inhi

137 In contrast, the gene copy number for several inflammatory cytokines incr

138 egulation would be due to a reduction in the gene copy number for sst2.

139 g exposure to ALI pulmonary edema fluid, the gene copy number for the major sodium and chloride trans

140 The revamped database also computes average gene copy numbers for any collection of entries selected

141 Gene copy numbers for sst subtypes 1-5 in IMR-32 cells w

142 itial step of gene amplification, increasing gene copy number from one to two or more.

143 ALK gene copy number gain was detected in the vast majority

144 us carcinoma patients is consistent with ALK gene copy number gain, whereas a stromal sarcoma patient

145 represent most of the major lineage-specific gene copy number gains and losses that have occurred in

146 We investigated 67 breakpoint junctions of gene copy number gains in 31 unrelated subjects.

147 cutoff values for HER2/CEP17 ratio and HER2 gene copy number (GCN) for discriminating positive resul

148 The gene copy number (GCN) varied from 2 to 6 for total C4,

149 ET, including one with EGFR mutation and MET gene copy number greater than 5.

150 associate with survival, whereas high IGF1R gene copy number harbors positive prognostic value.

151 ce of six retrogenes, accounting for ~13% of gene copy-number heterozygosity.

152 , we demonstrate that complex patterns of AR gene copy number imbalances occur in PCa cell lines, xen

153 th degree of aneuploidy and is partly due to gene copy number imbalances, suggesting that subtle chan

154 Gene copy number impacts on gene expression were detecte

155 We measured amylase gene copy number in 1,000 obese or lean Estonians and in

156 samples; this up-regulation correlates with gene copy number in a subset of melanoma cell lines.

157 We analyzed gene copy number in combination with microarray and GRO-

158 ant array was used to (i) measure changes in gene copy number in DNA from actively growing versus sta

159 organ and colleagues identified variation in gene copy number in Drosophila in the 1920s and 1930s an

160 of EGFR and HER2 protein expression and the gene copy number in NSCLC tumors may have a prognostic v

161 of EGFR were associated with increased EGFR gene copy number in NSCLC.

162 w qPCR assay for the estimation of the sxtA1 gene copy number in seawater samples during a bloom even

163 1R) protein expression, mRNA expression, and gene copy number in surgically resected non-small-cell l

164 importance of accurate determination of PLP1 gene copy number in the diagnosis of PMD and carrier det

165 and in Ts65DN mice; however, normalizing APP gene copy number in Ts65Dn mice fails to rescue plastici

166 e also show that the FISH test for the AURKA gene copy number in urine yielded a specificity of 79.7%

167 The EGFR gene copy numbers in 134 HNSCC tumors were determined us

168 ssion levels are tightly correlated with its gene copy numbers in human colorectal cancer.

169 chain reaction yielded similar dioxygenases gene copy numbers in unamended, PAC-, or GAC-amended soi

170 high epidermal growth factor receptor (EGFR)-gene-copy number in the intention-to-treat population.

171 amplified gene fragment, with respect to the gene copy numbers (in the starting DNA), is then establi

172 by conversion to homozygosity and increased gene copy number, in human tumors and tumor cell lines.

173 cluding nuclear shape, texture, context, and gene copy number, in order to rank objects according to

174 his study also revealed natural variation in gene copy number, including a duplication of the functio

175 xhibiting significant differences in CRPC in gene copy number, including gains in androgen receptor (

176 determine at what stage of tumor development gene copy number increase or phosphorylated Akt overexpr

177 tedly initiate DNA replication, resulting in gene copy number increases at several loci important for

178 aired normal tissues and frequently exhibits gene copy number increases in lung cancer.

179 the Ensembl public data, we have generated 'gene' copy number indices that facilitate the search for

180 d a significant, yet temporary impact; while gene copy numbers initially decreased 1-2 orders of magn

181 t have few or many CNAs, which we term CONIM genes (COpy Number Instability Modulators).

182 Finally, ATF3 gene copy number is >2 in approximately 80% of the breas

183 ve used a synthetic RNAi system to show that gene copy number is a key factor controlling RNAi for tr

184 Altering gene dosage through variation in gene copy number is a powerful approach to addressing qu

185 oncogenic activation of genes via increased gene copy number is a predominant mechanism for initiati

186 tRNA gene copy number is a primary determinant of tRNA abunda

187 strains of budding yeast had shown that when gene copy number is altered experimentally, RNA levels g

188 ng mutant and transgenic mice in which Gata3 gene copy number is altered, we show that ILC2 generatio

189 In this article, we demonstrate that gene copy number is an omnipresent parameter that can dr

190 High epidermal growth factor receptor (EGFR) gene copy number is associated with poor prognosis in lu

191 We have also demonstrated that PPP1CA gene copy number is increased in 21% of the OSCC cell li

192 Naturally occurring variation in gene copy number is increasingly recognized as a heritab

193 Variation in gene copy number is increasingly recognized as a source

194 Thus, N-myc gene copy number is modulated by alteration of HuD expre

195 AP2, which is mostly caused by its increased gene copy number, is likely to be associated with the de

196 This suggests that, by increasing gene copy number, localized endoreduplication serves as

197 1 cell clones also showed a higher degree of gene copy number loss and loss of heterozygosity in SNP

198 versity in mutant alleles and variability in gene copy number may also contribute to the heterogeneit

199 High EGFR gene copy number may be associated with poor outcome in

200 pstream regions combined with differences in gene copy numbers may be a factor in determining differe

201 tected by immunohistochemistry and increased gene copy number measured by fluorescence in situ hybrid

202 ours with discordant ERBB2-protein and ERBB2 gene copy number measurements.

203 leviation of fitness defects due to abnormal gene copy numbers might be an important function of prot

204 rs to FGFR inhibitors, relationships between gene copy number, mRNA expression and protein expression

205 , in a separate cohort of 69 tumors, IGF2BP1 gene copy number, mRNA, and protein abundance were deter

206 Then we inferred the changes in gene copy number (N), syntenies, and tuning sites along

207 Neither PIK3CA gene copy number nor phosphorylated Akt protein expressi

208 11 (95% CI, 2.27 to 21.90) and a median HER2 gene copy number of 11.90 (95% CI, 3.30 to 43.80) were f

209 By manipulating the gene copy number of an X-linked transcription factor, gi

210 the mutational status of exons 9 and 20 and gene copy number of PIK3CA using 86 non-small cell lung

211 ingly, one tumor displays an increase in the gene copy number of Pip4k2beta that is significantly mor

212 this report we demonstrate that reducing the gene copy number of Sp1 significantly increases both the

213 We examined the association between gene copy number of the PI3-kinase catalytic subunit alp

214 ations, including increases in expression or gene copy number of the receptor or ligands as well as d

215 sequently, it is often desirable to know the gene copy number of the transgenic organism and the zygo

216 We determined that although the relative gene copy number of TLR7 varied in both SLE patients and

217 lysis of quantitative traits associated with gene copy number of two important maize regulatory genes

218 In all cases, the gene copy numbers of DNA polymerase were low (<100/100 n

219 g cotton decaploidy has largely just reduced gene copy numbers of some homologous groups.

220 We quantified gene copy numbers of the pyruvate kinase, liver, and red

221 High-throughput measurement of gene copy number on large numbers of samples is a challe

222 gle switch motifs and show that variation in gene copy number, on the order of a single or few copies

223 risk patients with LOH-positive or high-EGFR-gene-copy-number OPLs.

224 high doses did not significantly alter sst2 gene copy numbers or binding of either the diagnostic do

225 erentiating as little as a 15% difference in gene copy number (or between 6 and 7 copies of a target

226 and epidermal growth factor receptor (EGFR) gene copy numbers, or mutated (somatic mutation rate of

227 re also significantly associated with PPP1CA gene copy number (P=0.014).

228 plification but in 0 of 12 without increased gene copy numbers (P = 0.00016).

229 ytical sensitivity of 2.0 x 10 degrees sxtA1 gene copy number per reaction.

230 ccording to HER2 FISH ratio and average HER2 gene copy number per tumor cell: group 1 (in situ hybrid

231 HER2 gene copy numbers per cell were evaluated by fluorescent

232 The finding that gene copy number polymorphism predisposes to immunologic

233 To investigate defensin gene copy number polymorphisms, a quantitative real-time

234 QPCR)-based arrays, we determined changes in gene copy number, pre-miRNA, and mature miRNA levels for

235 f 12 HER2 heterogeneous breast cancers using gene copy number profiling and massively parallel sequen

236 tal transition points caused by variation in gene copy number progressed through tissue development a

237 Alteration in gene copy number provides a simple way to change express

238 RNA genes and archaeal ammonia-monooxygenase gene copy number (qPCR) were significantly higher in hyp

239 chromosomes and represent a good example of gene copy number qualitatively altering a polygenic dise

240 An increased gene copy number ranging from 4 to 20 copies was identif

241 Thus, DPH gene copy number reduction does not affect overall dipht

242 a provide evidence that an increase in IGFIR gene copy number results in aberrant expression in the b

243 ions and in strains with a fourfold range in gene copy number revealed regulation at two levels: numb

244 ce copy number (T) compared to a single-copy gene copy number (S) using quantitative polymerase chain

245 nalysis of CREB mRNA expression and the CREB gene copy number showed that CREB overexpression occurre

246 to allow database searches based on 16S rRNA gene copy number, specific organisms or taxonomic subset

247 ency of genetic alterations at 1p36 and PER3 gene copy number status were analyzed in 180 lymph node-

248 t although protein levels largely scale with gene copy number, subunits of multi-protein complexes ar

249 en total (DEFA1+DEFA3) mRNA levels and total gene copy number, suggesting the superimposed influence

250 ength, telomere repeat copy number to single gene copy number (T/S) ratio and exposure to institution

251 While using gene copy number to regulate gene expression is limited

252 se sublimons allows individual mitochondrial gene copy numbers to vary independently between differen

253 re due to variation of (+)-3-carene synthase gene copy number, transcript and protein expression leve

254 he contribution of classical HLA alleles and gene copy number variation (CNV) at the hypervariable DR

255 We also found that gene copy number variation (CNV) can provide dual benefi

256 Gene copy number variation (CNV) has been shown to be as

257 We examined tRNA gene copy number variation (tgCNV) in six individuals; t

258 A genome-wide survey of gene copy number variation among human and great ape lin

259 Most recently, gene copy number variation and autoimmunity have been as

260 esion and secretion is affected by epistatic gene copy number variation and it is predictive of patie

261 We have investigated the alpha-tryptase gene copy number variation and its potential association

262 UBE3A gene copy number variation and the resulting overexpress

263 ome 16p11.2 microdeletion is the most common gene copy number variation in autism, but the synaptic p

264 we used genomic approaches to detect insulin gene copy number variation in rodent species and investi

265 We examined the effect of KIR gene copy number variation on the education of human NK

266 Gene copy number variation, a major source of genetic va

267 defensin expression by mucosal cells, due to gene copy number variation, alters the efficacy of recru

268 rse pool of allelic variants, which includes gene copy number variation, pseudogenes, and other polym

269 ipt provides an evolutionary alternative for gene copy number variation.Eukaryotic cells rely on the

270 Interindividual gene copy-number variation (CNV) of complement component

271 ome hybridization (aCGH), we have determined gene copy number variations (CNVs) common to five indust

272 p11.2 microdeletion is among the most common gene copy number variations (CNVs) known to confer risk

273 vity between populations and species include gene copy number variations and single-nucleotide polymo

274 anscript outlier data points with associated gene copy number variations that correlate with patient'

275 aracterized in terms of SNPs, chromosome and gene copy number variations, confirming that they are cl

276 also insertions and deletions, in particular gene copy number variations.

277 CAFs are significantly correlated with their gene copy number variations.

278 o further genome rearrangements and extended gene copy number variations.

279 High EGFR gene copy number was a predictor of a gefitinib-related

280 EGFR gene copy number was a predictor of clinical benefit fro

281 IGF1R gene copy number was assessed by fluorescent in situ hyb

282 EGFR gene copy number was assessed by fluorescent in situ hyb

283 NKX3.1 gene copy number was assessed by microsatellite analysis

284 31 patients with available tissue, high EGFR gene copy number was associated with worse overall survi

285 Prognostic value of high IGF1R gene copy number was confirmed in multivariate analysis.

286 MET gene copy number was determined in 14 cell lines and 23

287 lysis of genomic DNA confirmed that the rrm1 gene copy number was increased over 10-fold.

288 The EGFR gene copy number was not predictive of erlotinib efficac

289 Increased MET gene copy number was present with >10 copies in 3 of 23

290 The status of EGFR gene copy numbers was analyzed with clinical parameters

291 ic DNA hybridization to microarrays to assay gene copy number, we identified two additional developme

292 istry for p16, and fluorescence ISH for EGFR gene copy number were performed on tissue microarrays.

293 Gains in gene copy number were the principal type of mutations in

294 Assignments for gene copy numbers were achieved by relative standard cur

295 EGFR and HER2 gene copy numbers were assessed by fluorescence in situ

296 SMN2 gene copy numbers were determined using real-time quanti

297 ethene concentrations and Geobacter 16S rRNA gene copy numbers were measured.

298 angiosarcomas is achieved via increased Hras-gene copy number, which may be favored by a higher mutat

299 lic blood pressure in mice with reduced Npr1 gene copy number, which will have important implications

300 me sequencing, gene expression patterns, and gene copy number, will be required to gain a complete un