ライフサイエンスコーパス: gene deletion

1 ffectiveness of this method of adult cardiac gene deletion.

2 id metabolome and its response to systematic gene deletion.

3 and the vessels leaked upon ANG2 blockade or gene deletion.

4 through TRPA1 pharmacological antagonism or gene deletion.

5 om either of these cell types using Cre-loxP gene deletion.

6 hed in mice with alveolar epithelial Adora2b gene deletion.

7 n urothelium of mice using Cre-LoxP targeted gene deletion.

8 e expression was influenced by the RNase III gene deletion.

9 ntaneous SCC have been generated by a single gene deletion.

10 These changes mimic the effects of Kv1.3 gene deletion.

11 n combined with survivin mono- or bi-allelic gene deletion.

12 RNA pool of Saccharomyces cerevisiae by tRNA gene deletion.

13 exercise training or skeletal myofiber VEGF gene deletion.

14 ncestral genes and the other sustaining more gene deletions.

15 selectivity of the response to the targeted gene deletions.

16 mice with global or tissue-restricted SOAT2 gene deletions.

17 assive and rapid genomic reorganizations and gene deletions.

18 e most significantly disrupted by coincident gene deletions.

19 Lr(-/-) mice with each of the specific SOAT2 gene deletions.

20 Mad2 overexpression induced lethality in 13 gene deletions.

21 ic targets in cancers with tumour-suppressor gene deletions.

22 tly in patients with partial or complete VWF gene deletions.

23 sed on the coding region of the gene or full gene deletions.

24 or double (Trp53(-/-);Brca2(-/-)) suppressor gene deletions.

25 eration and independently acquired focal B2M gene deletions.

26 lowing: unmutated immunoglobulin heavy chain genes, deletion 17p or 11q, or trisomy 12.

27 6]) and often segregate for null alleles and gene deletions [3, 4, 7, 8].

28 dentical high BP, endothelial-specific Epas1 gene deletion accentuated albuminuria with severe podocy

29 These results show that Scn2a gene deletion acts as protective genetic modifier of SUD

30 Gene deletion analyses confirmed that the enoyl-CoA hydr

31 PTMs was supported by protein structure and gene deletion analyses.

32 Gene deletion analysis indicated that only the cel3B gen

33 Using somatic gene deletion and a pharmacological inhibitor, we found

34 Using gene deletion and adenoviral rescue, we demonstrate that

35 the utility of CRISPR/Cas9 for rapid serial gene deletion and also suggest that additional models ar

36 r neoplasm has been associated with both FXR gene deletion and BA-mediated metabolic abnormalities af

37 erformed two kinds of PSIP1 knockouts: whole-gene deletion and deletion of the integrase binding doma

38 Moreover, nrdh gene deletion and disruption experiments seem to indicat

39 Using gene deletion and function-blocking antibodies in mice,

40 Gene deletion and in silico analysis further delineated

41 fifth of the newly sequenced members share a gene deletion and one-third exhibit homopolymeric frames

42 thanosarcina acetivorans, enabling efficient gene deletion and replacement.

43 he broad use of the Gfi1(Cre) mice, both for gene deletion and reporter gene activation, these data a

44 -length erm(41) gene instead of the expected gene deletion and showed inducible clarithromycin resist

45 enetic approaches, including tissue-specific gene deletion and the use of various inflammatory trigge

46 ases, comprising three missense changes, two gene deletions and a novel point mutation within the 5'

47 complete due to the combinatorial amount of gene deletions and knockdowns required.

48 ed by combinatorially editing the genome via gene deletions and promoter replacements and by tuning t

49 To determine the evolutionary timing of the gene deletions and the genomic locations of the various

50 Gene-deletion and growth experiments in Methanosarcina a

51 hypoeosinophilic by anti-IL-5 antibody or by gene deletion, and in normal mice receiving cetirizine o

52 ardiac and muscle function in mice with Dmpk gene deletion, and studied post-maturity knockdown using

53 t shRNA essentiality profiles and homozygous gene deletions, and recapitulate mutant-specific mechani

54 ng and predicting the deleterious effects of gene deletions, and yet parallel computational methods f

55 We used targeted gene deletion approaches and pharmacologic interventions

56 Using gene deletion approaches, we demonstrate that this activ

57 and that Drosophila homozygous for ensconsin gene deletion are unable to survive to adulthood.

58 Importantly, NOX4 gene deletions are frequent in HCC patients, correlating

59 Because Vangl2 gene deletions are lethal, Vangl2 conditional knock-outs

60 een identified with OTCD due to a contiguous gene deletion at Xp11.4-p21.1 and unique clinical featur

61 Macrophage depletion and C1qa gene deletion attenuated the hypertension-induced beta-c

62 In conclusion, CMKLR1 gene deletion attenuates the effects of chronic DHT trea

63 The virus with the gene deletion, BeninDeltaDP148R, caused mild clinical si

64 that transient receptor potential A1 (TRPA1) gene deletion blocks CQ-induced scratching.

65 Furthermore, Traf3ip2 gene deletion blunts adverse remodeling 12 weeks post-I/

66 acapsular strain of C. gattii through CAP59 gene deletion by homologous integration.

67 IL9 antibody phenocopied the effects of IL9 gene deletion by slowing tumor progression in wild-type

68 Mouse cells in which MLL2 gene deletion can be induced display elevated levels of

69 nhibition, by either polymorphic mutation or gene deletion, can lead to the development of tumorigene

70 f future experimental interventions, such as gene deletions, can be improved by using our statistical

71 with focal dermal hypoplasia (FDH), whereas gene deletion causes embryonic lethality in mice.

72 B-cell-specific N-WASP gene deletion causes enhanced and prolonged BCR signalin

73 ng a non-essential Schizosaccharomyces pombe gene deletion collection, we identify deleted loci that

74 t was introduced into the yeast nonessential gene deletion collection.

75 ng patients (2.2% overall) had mitochondrial gene deletions consistent with Pearson marrow-pancreas s

76 hetic biology approach to create a series of gene deletion constructs and elucidate the biosynthetic

77 dy-resistant strains arising through further gene deletion could compromise such a strategy.

78 We propose that the contiguous gene deletion could contribute to the severity of the cl

79 ctivation, transcriptional interference, and gene deletion (CRISPR-AID) in the yeast Saccharomyces ce

80 Using mice heterozygous for cubilin gene deletion (cubilin HT mice), we show that cubilin ha

81 icial chromosome (BAC) constructs with ORF54 gene deletions, Delta54L (full ORF deletion) and Delta54

82 th the previously described, attenuating NS2 gene deletion (DeltaNS2) to produce the recombinant live

83 eurons, expression diminished thereafter and gene deletion did not alter brainstem NE neuron numbers.

84 ter cardiorespiratory arrest; and (iii) Aqp4 gene deletion did not impair transport of fluorescent so

85 gous in Jacobsen syndrome, an 11q contiguous gene deletion disorder involving thrombocytopenia, facia

86 We have now shown that mice with a Gnas gene deletion disrupting Gsalpha expression on the mater

87 arasite Plasmodium is refractory to targeted gene deletion during blood infection in the mammalian ho

88 er evidence for this model using conditional gene deletion during the regeneration of airway epitheli

89 A dual guide approach improved gene deletion efficacy in both cell types.

90 This gene deletion efficiently suppressed a key step in autop

91 SNAIL1 gene deletion either during the premalignant phase or af

92 NgR1 gene deletion enhances anatomical changes of inhibitory

93 s a role in their removal, and the RNase HII gene deletion enhances mutagenesis, suggesting a possibl

94 s, although many genes may be lost by single-gene deletion events, some may be lost in groups of cons

95 results also explain why patients with NFU1 gene deletions exhibit phenotypes that are indicative of

96 In contrast, C57BL/6 mice with BChE gene deletion exhibited increased ghrelin and fought mor

97 itional mutant mice die within 6 mo of Myocd gene deletion, exhibiting profound derangements in the s

98 through cell-based assays and cell-specific gene deletion experiments in mice, that the osteoclast d

99 studies, heterologous pathway expression and gene deletion experiments we are able to show that the N

100 nthetic gene cluster and the use of targeted-gene deletion experiments.

101 stmodification steps were mapped by targeted-gene-deletion experiments and the structural elucidation

102 PCRs in developing and adult beta cells, and gene-deletion experiments identified ADRA2A as a key Gi-

103 Conversely, enhanced ERK activity via Nf1 gene deletion extends the response and rescues both neur

104 ns, correlations between profiles of related gene deletions, gene-specific perturbations that reflect

105 Conditional hepatocyte Ext1 gene deletion greatly reduced AAV2 liver transduction fo

106 ntiviral shRNA-mediated GRK2 knockdown, GRK2 gene deletion (GRK2(flox/flox)/cre recombinase) and over

107 f plasma LDL showed that all mice with SOAT2 gene deletions had LDL CE with reduced percentages of ch

108 Each of the LDLr(-/-) mice with SOAT2 gene deletions had lower accumulations of total choleste

109 , to promote synapse formation; and Top3beta gene deletion has been linked to schizophrenia.

110 CT also benefitted patients with focal IKZF1 gene deletion (hazard ratio, 0.42).

111 SK3 isozymes yields distinct phenotypes from gene deletion, highlighting the power of the chemical-ge

112 Conversely, Ctrp6 gene deletion improved insulin action and increased meta

113 r expression of fluorescent proteins and for gene deletion in a model planctomycete, Planctopirus lim

114 METHODS AND Long-term global Vegfr3 gene deletion in adult mice resulted in increased fibrin

115 egulated after cardiac myocyte-directed Drp1 gene deletion in adult mice.

116 s (ie, MLL gene rearrangement or focal IKZF1 gene deletion in BCP-ALL and no NOTCH1/FBXW7 mutation an

117 Hyperactivation of mTORC1 via TSC1 gene deletion in chondrocytes causes uncoupling of the n

118 Targeted Hrd1 gene deletion in DCs diminished MHC-II expression.

119 Restricted beta1 integrin gene deletion in embryos using Ttr-Cre or Sox2-Cre indic

120 and myotonia and we identified a novel PNKD gene deletion in familial hemiplegic migraine.

121 FKBP5 gene in humans and the effect of Fkbp5 gene deletion in mice on alcohol withdrawal severity.

122 Vegfc gene deletion in mouse embryos results in failure of lym

123 myocyte- and fibroblast-specific conditional gene deletion in mouse models.

124 Next, we compared mice with conditional Syk gene deletion in myeloid cells (Syk(My)) versus Syk(f/f)

125 n) is a rare syndrome caused by a contiguous gene deletion in the 11p13-14 region.

126 e and zebrafish models confirm that survivin gene deletion in the kidneys results in a cystic phenoty

127 In vivo, RSK3 gene deletion in the mouse attenuated the concentric myo

128 Stage-specific gene deletion in trophoblasts reveals that loss of both

129 nced, to date there is no report on targeted gene deletion in U. virens and no molecular studies on g

130 -/-) mice, assessing the impact of Msx1+Msx2 gene deletion in vascular myofibroblast and smooth muscl

131 This is the first reported whole gene deletion in XIAP, the causal gene responsible for X

132 ta, which led us to identify a de novo whole gene deletion in XIAP.

133 pDGS), which is characterized by a number of gene deletions in chromosome 22, including the chicken t

134 re DNA changes in 15 mutants, including full gene deletions in ert-m.40 and ert-m.64.

135 responses in primary cells and in mice with gene deletions in Irf3, Irf5, and Irf7 or in Irf5 alone.

136 Missense mutations and whole gene deletions in RAD21 have been identified in children

137 roteome, growth rates were unaffected by the gene deletions in the seven-deletion strain.

138 es TRAF3IP2 expression in the heart, and its gene deletion, in a conditional cardiomyocyte-specific m

139 The gene deletions increased amyloid plaque load: APP/PS1 Gf

140 Initial studies with gene deletions indicate that nanT, predicted to encode t

141 phospholipid transporters, are refractory to gene deletion, indicative of essential functions.

142 Gene deletion-induced autophagy deficiency leads to neur

143 Mating assays demonstrate that gene deletion-induced phenotypic changes are stably inhe

144 emia, and the second, carrying a monoallelic gene deletion inducing a haploinsufficiency, presents on

145 LRP1 gene deletion is embryonic-lethal in mice.

146 the role of Cdk5 in GVHD, as germ line Cdk5 gene deletion is embryonically lethal.

147 r the left ventricle is also affected by VIP gene deletion is unknown.

148 To better understand how gene deletions lead to altered neuronal activity, we inv

149 Rif1 depletion by RNAi or gene deletion led to increased transcription and increas

150 We generate double-gene deletion libraries to demonstrate this technology,

151 CLIC4 gene deletion markedly attenuated the development of chr

152 sFRP-1 gene deletion mice were grossly normal with no differenc

153 Using gene deletion models that eliminate tumor necrosis facto

154 y comparing parental B. pertussis to an rseA gene deletion mutant (PM18), we sought to characterize t

155 rus type 5 (Ad5) E1B 19-kilodalton (E1B 19K) gene deletion mutant did not repress macrophage NF-kappa

156 Overall, as the first report of targeted gene deletion mutant in U. virens, our results showed th

157 ntial production of 128 proteins in the oxyR gene deletion mutant, indicating its global regulatory r

158 to Leishmania major by generating individual gene deletion mutants (Deltaatg4.1 and Deltaatg4.2); dou

159 ng in C. elegans, we utilized the individual gene deletion mutants in E. coli (K12).

160 o molecular analyses using defined virulence gene deletion mutants in that lineage as of yet.

161 lence characteristics, and produced isogenic gene deletion mutants of important CA-MRSA virulence det

162 ilico examination of the inferred fitness of gene deletion mutants suggests that secondary replicons

163 model to screen a library of targeted single-gene deletion mutants to identify novel genes of Salmone

164 The ability of these OMP gene deletion mutants to induce immune responses was com

165 Twelve single gene deletion mutants were under selection in this assay

166 pattern of yeast Pex11 in all non-essential gene deletion mutants, as well as in temperature-sensiti

167 By screening a panel of 39 gene deletion mutants, each lacking a different ubiquiti

168 Through construction of gene deletion mutants, we determined that an sspB scpA d

169 Using gene deletion mutants, we show that SCF(Cdc4) and Ubp3 h

170 l polypeptides were determined for these OMP gene deletion mutants.

171 Bar-seq) screening of a pooled collection of gene-deletion mutants cultivated as biofilm and plankton

172 accine strategy for Burkholderia, but single-gene-deletion mutants have not provided complete protect

173 Analogous single-gene deletion mutations of these genes showed significan

174 he physiological role of ASNA in Leishmania, gene deletion mutations were attempted via targeted gene

175 physiological role of LdTyrRS in Leishmania, gene deletion mutations were attempted via targeted gene

176 We identify a comprehensive set of fixed gene deletions (n = 340) and duplications (n = 405) as w

177 However, neither TNF-alpha gene deletion nor anti-TNF-alpha neutralizing antibodies

178 ts prostate cancer metastases and as neither gene deletions nor inactivating mutations of PPM1A have

179 WWOX gene deletions occur in a variety of human cancer types,

180 Systematic gene deletion of conserved ApiAP2 genes in Plasmodium co

181 Individual gene deletion of dynamin 1, a primary dynamin isoform in

182 y in vivo, we generated mice with a targeted gene deletion of Ifi27l2a.

183 uses using cells and animals with a targeted gene deletion of Ifitm3 as well as deficient cells trans

184 litic flavivirus, using mice with a targeted gene deletion of Ifitm3 Based on extensive virological a

185 Gene deletion of intermediates of Wingless-related integ

186 Gene deletion of LdASNA showed a growth delay in mutants

187 In obstructed kidneys from mice with gene deletion of Mas (Mas(-/-)), apoptosis and macrophag

188 models of vascular calcification, mice with gene deletion of matrix Gla protein, a bone morphogeneti

189 We used conditional gene deletion of MR signaling in myeloid cells (MR(flox/

190 A double gene deletion of RCF2 and RCF3 affects cellular survival

191 Zinc-finger nuclease-mediated targeted gene deletion of the major rat macrophage epoxygenase Cy

192 lation on ventricular repolarization through gene deletion of the sialyltransferase ST3Gal4.

193 Intriguingly, although gene deletion of TRPC3 or TRPC6 alone did not protect ag

194 mmon disease-associated mutation in the CFTR gene-deletion of Phe508 (DeltaF508) leads to a biosynthe

195 optimization of non-structural (NS1 and NS2) genes, deletion of the small hydrophobic (SH) gene, codo

196 Here, we used MMTV-Cre-mediated Cbl gene deletion on a Cbl-b null background, as well as a t

197 previous reports, we found no effect of Dmpk gene deletion on cardiac or muscle function, when studie

198 the functional consequences of neuronal Ifnb gene deletion on PD-L1 signaling and function.

199 cell sorting to assess genome-wide impact of gene deletions on membrane protein expression.

200 This number is based on gene deletions only and represents a lower limit, yet th

201 lder than those observed with beta1 integrin gene deletion or a beta1 double Y-to-A substitution (bet

202 CX3CR1 gene deletion or anti-Abeta immunotherapy causes expansi

203 tical role of DC-HIL was supported by DC-HIL gene deletion or anti-DC-HIL treatment, which abrogated

204 hannel function has been abolished either by gene deletion or by acute pharmacological blockade.

205 ed by using traditional studies with haploid gene deletion or conditional alleles.

206 Absence of ODZ1 by gene deletion or downregulation of ODZ1 by small interfe

207 Inhibition of PARP1 through gene deletion or drug inhibition reversed behavioral def

208 c B cells with subsequent acute induction of gene deletion or expression, we demonstrate that the con

209 In mice, nNos gene deletion or inhibition shortened atrial APD and inc

210 e liver regeneration using Cre/loxP-mediated gene deletion or intravenous delivery of beta1-integrin

211 weeks and 6 months, who had SMN1 homozygous gene deletion or mutation.

212 used to achieve tooth root formation-related gene deletion or overexpression, as well as strengths an

213 Gene deletion or selective drug blockade of TRPC6 or cGM

214 on of cathepsin B expression via CRISPR-Cas9 gene deletion or shRNA knockdown had no effect on the ef

215 Rnd3 deficiency, through either gene deletion or siRNA knockdown, resulted in a decrease

216 DAMTS13 activity resulting from the ADAMTS13 gene deletion or the antibody-mediated inhibition of pla

217 To that end, the effects of various gene deletions or chemical blocking agents were tested b

218 Some gene deletions or mutations have little effect on metabo

219 Targeted gene deletion, or conditional mutation, of genes encodin

220 overexpression, gene knockdown, Cre-mediated gene deletion, or CRISPR/Cas9-mediated (where CRISPR ind

221 Transgenic gene deletion/over-expression studies have established t

222 system has become a powerful tool, allowing gene deletion, overexpression, and ectopic expression in

223 geting an integrated egfp locus, we obtained gene-deletion parasites with unprecedented speed (2 week

224 Through extensive gene deletion, pathway-targeted molecular networking, qu

225 Using a combination of cell-type-specific gene deletions, pharmacology, and chemogenetics, we foun

226 comparative analysis of bacterial growth and gene deletion phenotypes using hundreds of genome-scale

227 e, IGHJ gene usage is unaffected by the IGHD gene-deletion polymorphisms.

228 a majority of cases whereas a more complete gene deletion predisposes to leukemia.

229 ing JNK1/2 activation by either jnk1 or jnk2 gene deletion prevents ER stress.

230 Moreover, endothelial-specific RhoA gene deletion prevents vascular leakage and passive cuta

231 Synapsin II (SynII) gene deletion produces a deficit in inhibitory synaptic

232 Inpp5f (Sac2) gene deletion promoted recovery from spinal cord injury

233 Here, we report the construction of a double-gene-deletion recombinant virus, ASFV-G-Delta9GL/DeltaUK

234 Gene deletion/replacement experiments in Drosophila show

235 ASO therapy, especially since mice with Dmpk gene deletion reportedly show cardiac defects and skelet

236 only used for conditional hair cell-specific gene deletion/reporter gene activation in the inner ear.

237 However, Mif gene deletion restricted to renal tubular epithelial cel

238 Moreover, Gfap and Vim gene deletion resulted in a marked increase in dystrophi

239 Hif1a gene deletion resulted in a significant loss of YFP(+) N

240 Shisa7 gene deletion resulted in faster AMPAR currents in CA1 s

241 In murine prostate epithelium, PPARD gene deletion resulted in increased cellularity.

242 to study stress responses, we observed that gene deletions resulting in the highest thermosensitivit

243 We recently reported that Efnb3 gene deletion results in hypertension in female but not

244 t on CRISPR/CAS9 technology-mediated ALX/FPR gene deletion revealed the importance of the lipoxin rec

245 Here we evaluated heterozygous Scn2a gene deletion (Scn2a+/-) as a protective genetic modifie

246 of MAPK signaling, we performed CRISPR-Cas9 gene deletion screens in the setting of BRAF, MEK, EGFR,

247 aploid deletion collection and identified 27 gene deletions sensitive to both low oxygen and cobalt c

248 r basic protein-1/eosinophil peroxidase dual gene deletion) show that eosinophils are required for al

249 Conditional gene deletion showed a cell-intrinsic requirement of CD2

250 Its gene deletion showed only mild phenotypes.

251 omic screens in the Saccharomyces cerevisiae gene-deletion strain collection, identifying edelfosine-

252 nas palustris In vivo metabolite analysis of gene deletion strains demonstrated that this anaerobic M

253 tion of the respective protein kinase single-gene deletion strains.

254 Repression of TORC1 by rapamycin in the gene-deletion strains completely reversed their sensitiv

255 n, under carbon starvation, the HSP31 family gene-deletion strains display impaired autophagy, disrup

256 ort the construction of 264 signature-tagged gene-deletion strains for 129 putative kinases, and exam

257 high-quality library of 322 signature-tagged gene-deletion strains for 155 putative TF genes previous

258 Growth phenotype profiling of genome-wide gene-deletion strains over stress conditions can offer a

259 an inducible endothelial-cell-specific mouse gene deletion strategy and complementary models of acute

260 Here, we have used a conditional gene deletion strategy in mice to probe the specific rol

261 Gene deletion studies indicate that Leishmania SepSecS i

262 the production of virulence factors based on gene deletion studies of the sae and agr two-component s

263 Finally, gene deletion studies show thatCjLPMO10A is needed byC.

264 Cell-fate mapping and gene-deletion studies using zG-specific Cre expression d

265 Previous gene deletion study revealed a role for PRL2 in spermato

266 A gene deletion study revealed that Srx1 was required for

267 Neither the gM nor UL11 gene deletion substantially affected gB, gC, gD, gE, and

268 y abnormalities were not related to specific gene deletions suggesting a "neighboring effect" of regi

269 either by pharmacologic inhibition or Gsk3a gene deletion, suppressed autophagy in fibroblasts.

270 yndrome) is the most common known contiguous gene deletion syndrome and is associated with diverse ne

271 dress this, we have implemented an inducible gene deletion system based on a dimerised Cre recombinas

272 We also established a CRISPR/Cas9 gene deletion system in this NF-kappaB reporter line, en

273 in the group with heterozygous or homozygous gene deletions than in those with no deletion.

274 ong with an additional seven genes and three gene deletions that enhance secondary metabolism.

275 h was identified by a genome-wide screen for gene deletions that impair the fitness of aneuploid yeas

276 In mice with the TLR4 gene deletion, this bacteremia-evoked Sca-1 response was

277 ing the central THP core were isolated after gene deletion (tmlF).

278 By using temporal Cre recombinase-mediated gene deletion to ablate SAP expression after completion

279 The preferred method is methodical gene deletions to identify supporting enzymes for key sy

280 sgenic x PTEN(flox/flox) mice, which enabled gene deletion using a Cre adenovirus in vitro.

281 hed results and to properly control targeted gene deletions using the lck-cre(+) strain.

282 Targeted gene deletion verified that the F. fujikuroi polyketide

283 Thus, gene deletion via viral co-delivery of CRISPR-Cas9 in pr

284 We used gene-deletion viruses to evaluate the role of the attach

285 Biallelic Tsc1 gene deletion was induced in adult Tsc1 heterozygous and

286 When Cdk5 gene deletion was induced in nestin-expressing cells and

287 Acute gene deletion was not accompanied by any obvious histolo

288 Snai1 gene deletion was, however, only partial and could there

289 Using targeted gene deletion, we generated a set of 28 isogenic mutants

290 Using conditional, cardiac myocyte-specific gene deletion, we now demonstrate that mAKAPbeta express

291 using a mouse strain that allows post-thymic gene deletion, we show that ThPOK maintains CD4(+) T lin

292 Using targeted gene deletions, we have identified a cluster of nine gen

293 Using a series of gene deletions, we show that four of the five genes are

294 Using targeted gene deletions, we verify the importance of a highly exp

295 an instance of uniparental disomy, and whole-gene deletion were identified in nine patients from eigh

296 et deletion strains revealed that two of the gene deletions were dispensable under the conditions tes

297 allenging genome-editing procedures, such as gene deletion, which is important for inducing a loss of

298 lude duplications, point mutations, or whole gene deletions with a continuum of phenotypes ranging fr

299 Current systems for conditional gene deletion within mouse macrophage lineages are limit

300 However, pfhrp2 gene deletions yielding false-negative RDTs, first repor