ライフサイエンスコーパス: gene dosage

1 etected (a 2x decrease or a 1.5x increase in gene dosage).

2 g an isogenic iPSC line with normalized SNCA gene dosage.

3 s state, demonstrating a tight dependence on gene dosage.

4 methylation states in both models of reduced gene dosage.

5 uced 50% in several tissues, consistent with gene dosage.

6 n PKD involving miRNAs and regulation of PKD gene dosage.

7 sification rather than by the maintenance of gene dosage.

8 hat is sensitive to both genetic context and gene dosage.

9 lts were obtained with MET and HGF, nor with gene dosage.

10 ncreased expression of trisomic genes due to gene dosage.

11 ozygotes, indicating sensitivity to Tra2beta gene dosage.

12 usage, which was corrected by reducing Fgf9 gene dosage.

13 ly alter DNA content, chromosome number, and gene dosage.

14 uced TNF-R1 shedding was dependent on the A8 gene dosage.

15 ram and regulated by a balanced SOX17-BLIMP1 gene dosage.

16 ighly sensitive to genetic background and to gene dosage.

17 and p53 are consistent across cell types and gene dosage.

18 pression changes by increasing or decreasing gene dosage.

19 stral functions and selection for changes in gene dosage.

20 nheritance and susceptibility as they affect gene dosage.

21 show altered expression even with increased gene dosage.

22 pment toward the colon as a function of Muc2 gene dosage.

23 a Dyrk1a inhibitor or by normalizing Dyrk1a gene dosage.

24 and accurate method for detecting changes in gene dosage.

25 on are consistent with selection on relative gene dosage.

26 lization, whereas others focus on sharing of gene dosage.

27 ted, suggesting combined roles in regulating gene dosage.

28 otype can be largely rescued by reducing Ret gene dosage.

29 ing levels of aneuploidy with decreasing Tau gene dosage.

30 fect that is suppressed by reduction in Wnt5 gene dosage.

31 lities, which may depend on both age and Cre gene dosage.

32 ron acts as a backup to maintain appropriate gene dosages.

33 n forces: selection on relative and absolute gene dosages.

34 nts (33A and 33B) with widely different rRNA gene dosages.

35 come used widely to study DS, the effects of gene dosage abnormalities, and the effect on the basic b

36 ated autoimmunity, because reduction of Tlr7 gene dosage abolished the Yaa phenotype.

37 Our results indicate that subtle changes in gene dosage across a chromosome can have significant phe

38 We demonstrate that IZH2 and IZH3 gene dosage affects resistance to polyene antifungal dru

39 ome are apparently beneficial to rebalancing gene dosage after duplication.

40 us and mosaic mutant mice with reduced Robo2 gene dosage also exhibit striking CAKUT-VUR phenotypes.

41 ciliary trafficking, but reduction of Ift122 gene dosage also suppresses the Dync2h1 phenotype.

42 nnels and that increased and decreased shn-1 gene dosage alter L-channel current and activity-induced

43 epresent complete deletions but do represent gene-dosage alterations, impact cancer cell functions?

44 Finally, reducing SPARC gene dosage ameliorated the cardiomyopathy that develope

45 Therefore, decreased Npc1 gene dosage among two different mouse strains interacts

46 has given rise to highly variable Hodgkinia gene dosages among species.

47 hich conventional OPA1 diagnostics including gene dosage analyses were normal.

48 We have used gene dosage analysis by quantitative PCR to identify lar

49 ) is an efficient and reliable technique for gene dosage analysis.

50 These data demonstrate that Lyn gene dosage and activity are critical for normal erythro

51 important mechanism in evolution, affecting gene dosage and allowing for the acquisition of new gene

52 in are strongly suppressed by increased drp1 gene dosage and by heterozygous loss-of-function mutatio

53 ate organogenesis is critically sensitive to gene dosage and even subtle variations in the expression

54 global analyses of the relationship between gene dosage and expression.

55 ppressors by broadly decreasing the resident gene dosage and expression.

56 ed sex chromosomes: compensation of X-linked gene dosage and modulation of heterochromatin.

57 ulsive seizures, and is dependent upon Celf4 gene dosage and mouse strain background.

58 f quantitative trait loci that may influence gene dosage and mutational frequency and provide mechani

59 s also suggest that miRNAs may modulate PKD1 gene dosage and play a role in the initiation of cystoge

60 signaling in the liver is sensitive to Jag1 gene dosage and suggest a role for the Notch pathway in

61 ber vascular development is sensitive to Tek gene dosage and the resulting decrease in angiopoietin-T

62 lopmental programs that depend critically on gene dosage and timing.

63 r, and its activity levels are controlled by gene dosage and transcriptional and post-translational m

64 important for maintaining genome stability, gene dosage, and epigenetic inheritance; however, the mo

65 To dissect cell type sensitive to Stat5 gene dosage, animals with Stat5 haplo-insufficiency in T

66 Changes in gene dosage are a major driver of cancer, known to be ca

67 mma2 genomic locus we show that reducing the gene dosage at postnatal days (P)13/14 but not P27/28 re

68 ntial loss/retention of miRNAs following the gene dosage balance rule.

69 oids, including maternal-paternal influence, gene dosage balance, cis- and/or trans-regulatory networ

70 osome inactivation, which equalizes X-linked gene dosage between male and female mammals.

71 ifferentiated sex chromosomes, imbalances in gene dosage between the sexes can affect overall organis

72 and inactive chromosomes to balance X-linked gene dosages between males and females.

73 Mammals compensate for unequal X-linked gene dosages between the sexes by inactivating one X chr

74 of one X chromosome in the female equalizes gene dosages between XX females and XY males.

75 ation of Thr(240) to Ala is lethal at normal gene dosage, but an increased copy number of this mutant

76 cbl mRNA in the ovary and that reducing cbl gene dosage by half rescues the dFmr1 oogenesis phenotyp

77 Mammals balance X-linked gene dosage by silencing one X chromosome in female cell

78 , and addressed potential effects of altered gene dosage by studying Ca(V)1.2 knockout heterozygotes.

79 changes are all mechanisms by which altered gene dosage can cause the failure of neuronal homeostasi

80 Knockdown mouse models, where gene dosages can be modulated, provide valuable insights

81 adic Parkinson's disease (PD), and increased gene dosage causes a severe, dominantly inherited form o

82 Gene dosage change is a mild perturbation that is a valu

83 refining the fitness benefits of aggregated gene dosage changes.

84 Gene dosage compensation adjusts the total Qrr1-4 sRNA p

85 onal bursts reveals a separate mechanism for gene dosage compensation after DNA replication that enab

86 one involving the sRNA-target HapR, promotes gene dosage compensation between the four qrr genes.

87 required for the regulation of X chromosome gene dosage compensation in Drosophila males.

88 r factors are involved in the fine tuning of gene dosage compensation in neutrophils.

89 tively regulated as well as in the degree of gene dosage compensation.

90 es of the affected chromosomes, to show that gene-dosage compensation functions at >30% of amplified

91 to sex bias of autosomal versus Z chromosome genes, dosage compensation, and evolution of sex bias.

92 modifications needed for developmental rRNA gene dosage control.

93 Here, we discuss the importance of Nf1 gene dosage, delineate hematopoietic contributions to th

94 Furthermore, varying foraging gene dosage demonstrates a linear dose-response on these

95 results suggest that the effects of MIR2 are gene dosage dependent and that low levels of this viral

96 The low-HFA trait was heritable and gene dosage dependent, with hemizygous lines showing int

97 onocyte population via a cell autonomous and gene-dosage dependent mechanism.

98 Rescue is gene-dosage dependent, with loss of even one allele of G

99 Using wounding treatment, we discovered gene dosage-dependent activation of MPK3 and MPK6.

100 Biochemical analyses revealed Jak2V617F gene dosage-dependent activation of Stat5, Akt, and Erk

101 Mouse plasma PIP2 levels are apoA1 gene dosage-dependent and are >1 muM in apoA1 transgenic

102 ogenitors of all hematopoietic lineages in a gene dosage-dependent and cell-autonomous manner.

103 ent growth defect of the sec3-913 strain was gene dosage-dependent and suppressed by blocking the pro

104 ning transcription regulator 1 (Taz) exhibit gene dosage-dependent cardiac phenotypes, suggesting red

105 ereas the missense c.1781G>A lesion caused a gene dosage-dependent channel reduction at the cell memb

106 The gene dosage-dependent function of SIRT1 in DNA repair an

107 ere we show that Crkl mutant embryos exhibit gene dosage-dependent growth restriction, and homozygous

108 knock-in animals, which develop an age- and gene dosage-dependent hypertrophic cardiomyopathy and he

109 Our results reveal the gene dosage-dependent in vivo functions of SIRT1 in skin

110 lling repression, we highlight a synergistic gene dosage-dependent interaction between Hesx1 and Tcf3

111 rgeted inactivation of the Tpm4 locus led to gene dosage-dependent macrothrombocytopenia in mice.

112 way effectors YAP and TAZ are required, in a gene dosage-dependent manner, for the proliferation and

113 abnormalities in the RPE in an age- and Cre gene dosage-dependent manner, which needs to be consider

114 nd2 is required for reporter activation in a gene dosage-dependent manner.

115 s in wild-type and Munc18c (-/+) islets in a gene dosage-dependent manner.

116 ependent on the action of Pol IV in a (dinB) gene dosage-dependent manner.

117 These mice exhibit an Ank3 gene dosage-dependent phenotype including behavior chang

118 gatively regulates endogenous Pum, producing gene dosage-dependent pum loss-of-function NMJ phenotype

119 iferation and differentiation in skin show a gene dosage-dependent requirement for the Erk1/2 MAPK ca

120 ntaining the SFA1 and CUP1 genes that confer gene dosage-dependent tolerance to formaldehyde and copp

121 Mrp4-deficient mice experienced Mrp4 gene dosage-dependent toxicity caused by accumulation of

122 We show that apparent gene dosage discrepancies between humans and model organ

123 Thus, diminished 22q11.2 gene dosage disrupts cortical circuit development by mod

124 Thus, diminished 22q11 gene dosage disrupts cortical neurogenesis and interneur

125 nd isogenic GAS mutants demonstrate that shp gene dosage does contribute to Rgg2/3 system induction,

126 sults, we conclude that selection for higher gene dosage does not play a major role in driving the fi

127 However, changes in gene dosage during sex-chromosome evolution are not expe

128 For the MRGCs, we found a gene dosage effect for Dscam, with the Dscam+/- retinas

129 Molecular analysis confirmed a gene dosage effect of delta-catenin on Rho GTPase activi

130 is by melanocortin signalling, including the gene dosage effect of MC4R and the sustained effects of

131 A strong gene dosage effect was also evident because both Arg- an

132 Given this gene dosage effect, FHL is not strictly recessive.

133 one functional Smad4 allele revealed a sharp gene dosage effect, suggesting the existence of a thresh

134 had minimal to no iron loading, suggesting a gene dosage effect.

135 y in their T cells is impaired, suggesting a gene-dosage effect of the mutation.

136 We found a gene-dosage effect on cognitive and motor function at 15

137 ata from obese human subjects, we observed a gene-dosage effect that links SORLA expression to obesit

138 rable genotype analyses also showed a strong gene-dosage effect with decreased survival and increased

139 llows us to determine whether sex chromosome gene dosage effects exist.

140 o improve our understanding of chromosome 21 gene dosage effects in human hematologic malignancies.

141 Increasing recognition of gene dosage effects in neurodevelopmental disorders prom

142 We tested phenotypic homogeneity and gene dosage effects in the mouse null alleles muted (Blo

143 the cortex and cerebellum to illustrate how gene dosage effects might contribute to divergence betwe

144 des an alternative approach to investigating gene dosage effects not possible in sexually propagated

145 Here we investigated the influence of gene dosage effects on adiposity through a CNV associati

146 Here we conducted the first study of 22q11.2 gene dosage effects on brain structure in a sample of 14

147 Beyond gene dosage effects on global brain metrics, we show tha

148 nced infection in trans is presumably due to gene dosage effects since their presence on plasmids inc

149 embryonic brain samples having the smallest gene dosage effects, and adult gonadal tissue having the

150 lyzed, or post-transcriptional regulation of gene dosage effects.

151 the CD45E613R mutation, manipulation of TLR9 gene dosage eliminates ANA in CD45E613R.BALB/c mice, but

152 The resulting mitotic defects, supported by gene dosage experiments and time-lapse microscopy of liv

153 Furthermore, gene-dosage experiments demonstrate that integrin alpha3

154 on for ASXL1 and EZH2 mutations or perturbed gene dosage for copy-number changes.

155 type 1A (CMT1A) is associated with increased gene dosage for PMP22.

156 nificantly decreased with a reduction of p53 gene dosage from 44% in Twsg1(-/-)p53(+/+) pups (N=675)

157 o infer the roles of functional promiscuity, gene dosage, gene duplication, point mutations, and sele

158 elic duplications-and that this variation in gene dosage generates abundant variation in gene express

159 lusion, perturbing Yan expression by varying gene dosage had no effect on cell fate transitions.

160 which organisms respond to changes in their gene dosage has long fascinated geneticists.

161 ving because of the differential effect that gene dosage has on the fitness of matrilineal and patril

162 The resulting imbalance in gene dosage has phenotypic consequences that are specifi

163 lection for increased gene dosage (i.e., the gene dosage hypothesis), because haploinsufficient genes

164 t preferential retention consistent with the gene dosage hypothesis, but a third gene family, includi

165 ention of clock genes is consistent with the gene dosage hypothesis, which predicts preferential rete

166 y driven by positive selection for increased gene dosage (i.e., the gene dosage hypothesis), because

167 The mechanisms by which gene dosage imbalance affects gene expression and phenot

168 ptionally suppressing the adverse effects of gene dosage imbalance and harmful FBX alleles that arise

169 This condition results in gene dosage imbalance and often causes severe phenotypic

170 close to the terminus, leads to a transient gene dosage imbalance during chromosome replication.

171 hat PtdIns(4,5)P(2) dyshomeostasis caused by gene dosage imbalance for Synj1 may contribute to brain

172 However, the consequences of the underlying gene-dosage imbalance on adult tissues remain poorly und

173 hromosomes leads to the potential problem of gene dosage imbalances between autosomes and sex chromos

174 er variations in the human genome leading to gene dosage imbalances comprise approximately 12% of the

175 A reduction of Hand2 and Shh gene dosage improves the integrity of anterior limb stru

176 maly, which can be rescued by increased Pax6 gene dosage in Cited2(-/-) embryonic eyes.

177 been extensively studied, the role of Stat5 gene dosage in contact allergies has not been addressed.

178 Reduced beta3 gene dosage in elastin-null mice mitigates pathological

179 t that a combined reduction of PAX9 and MSX1 gene dosage in humans may increase the risk for orofacia

180 c imprinting is implicated in the control of gene dosage in neurogenic niches.

181 hough this underscores the importance of Pax gene dosage in normal development, how differential leve

182 Our analysis of mice with 50%-reduced Sox9 gene dosage in pancreatic progenitors reveals endocrine-

183 ression of mutant and wild-type PS1 at equal gene dosage in presenilin-deficient mouse embryo fibrobl

184 cated allele of TCF3 and a reduction of PAX5 gene dosage in TCF3-HLF ALL suggest cooperation within a

185 Lowered Neurog3 gene dosage in the developing pancreatic epithelium redu

186 Reduction of TGFbeta2 gene dosage in the RA receptor-deficient background rest

187 We found that the lower fis gene dosage in the strains with terminus-proximal dusB-f

188 us epilepsy (PME) in humans, and its reduced gene dosage increases sensitivity to induced seizure in

189 NPC1 mouse model (Npc1) with decreased Npc1 gene dosage independently supported these results by sug

190 urely, in a manner that correlated with Ccr2 gene dosage, indicating that absence of early microglial

191 autosomal dominant, autosomal recessive, and gene-dosage interactions.

192 +/-) mice and determined that decreased Npc1 gene dosage interacts with a high-fat diet to promote we

193 RAI1 gene dosage is associated with the PTLS phenotypes.

194 sion in sympathetic neurons, even when Hand2 gene dosage is concurrently reduced by half.

195 The resulting imbalance in gene dosage is corrected by increased expression from th

196 Bim gene dosage is critical in modulating nephron progenitor

197 We conclude that Eklf gene dosage is crucial for regulating the surface phenot

198 Deane et al. show that Tlr7 gene dosage is directly related to the risk of lupus in

199 In planta, increasing NEDD8 gene dosage is sufficient to suppress den1 mutant phenot

200 Interestingly, changes in sprouty gene dosage led to a graded change in incisor number, wi

201 oarray (SNP-chip) is a useful tool to define gene dosage levels over the whole genome, allowing preci

202 Together, these results reveal that RP gene dosage limits the differentiation, not the self-ren

203 type 1 neuropathy caused by reduced P0 (MPZ) gene dosage, macrophage blockade causes an improved pres

204 ent study, we examine zebrafish MTMR14 using gene dosage manipulation.

205 lture and mice in which Perk was impaired or gene dosage modulated.

206 We investigated the effect of Stat5 gene dosage modulation in contact allergies using CHS in

207 Here, we manipulate the gene dosage of a signaling molecule, Fgf8, a critical re

208 In addition, we examined the role of gene dosage of beta-arr2 in polymicrobial sepsis.

209 g dependence of this social behavior on TSC2 gene dosage of both parties involved.

210 Sdf1a and (iii) buffers against variation in gene dosage of chemokine signaling components to ensure

211 Decreasing the gene dosage of Dl enhanced the multiple-R8 phenotype, wh

212 -)/(-); Spry2(-)/(-) embryos by reducing the gene dosage of Fgf10.

213 Additionally, reducing the gene dosage of Fgf8 rescued pharyngeal arch artery defec

214 Gene expression and gene dosage of MACC1, hepatocyte growth factor (HGF), an

215 Increasing gene dosage of more than half of the missense alleles fu

216 Here we show that reduced gene dosage of NR4A1 and NR4A3 in hypoallelic (NR4A1(+/-

217 Using mice with reduced gene dosage of p190rhogap, a cytoskeletal regulatory pro

218 tructural alteration that increases both the gene dosage of PD-1 ligands and their induction by JAK2,

219 The correct gene dosage of PMP22 is critical; a duplication of PMP22

220 Finally, we showed that gene dosage of Prnp regulates Abeta-induced Fyn/tau alte

221 Yet, the gene dosage of Rex1 is very critical for the survival of

222 Reduced gene dosage of ribosomal protein subunits has been impli

223 In stark contrast, doubling of the gene dosage of the activated Ha-ras triggered early-onse

224 erated cocaine sensitization, as did reduced gene dosage of the Arg substrate, p190RhoGAP.

225 ave some method to counteract the effects of gene dosage of the dominant sex chromosome in males and

226 interferon activation, likely via increased gene dosage of the four interferon receptors encoded on

227 show that an approximately 50% reduction in gene dosage of the mixed lineage leukemia 3 (MLL3) gene,

228 We addressed this question by reducing gene dosage of the pDC-specific transcription factor E2-

229 t Jag1-induced signaling is sensitive to the gene dosage of the protein O-glucosyltransferase Rumi.

230 esulting from decreased Arg levels, reducing gene dosage of the Rho effector ROCKII can suppress the

231 in CDH1-m11 cells is strikingly sensitive to gene dosage of the stoichiometric Cdh1 inhibitor ACM1.

232 Hence, increased gene dosage of VAMP7, and thus higher expression levels

233 Reducing the gene dosage of Wt1 or Sf1 in Cited2 mutant gonads was su

234 efungin stem from the finding that increased gene dosage of yeast AdoMet synthase plus cap guanine-N7

235 penetrant type of autism linked to increased gene dosages of UBE3A, which encodes a ubiquitin ligase

236 e directions with more widespread effects of gene dosage on cortical surface area.

237 dentify differential effects of altered Hus1 gene dosage on genome maintenance during in vitro cultur

238 ermine the effects of reduced Smad3 or CD2AP gene dosage on podocyte apoptosis and proteinuria charac

239 Investigations into the effect of parental gene dosage on seed development have revealed that MADS

240 Reducing the Fgf8 gene dosage only partially rescued defects in the glosso

241 mosome 21 or the rob(15;21)c chromosome with gene dosage optimized for leukaemic potential, showing c

242 Increasing APP gene dosage or expression has been shown to cause famili

243 itness of the involved organisms by doubling gene dosage or neofunctionalization, it may also result

244 Reducing Wnd gene dosage or overexpressing its antagonist highwire pa

245 ng that additional genetic factors, possibly gene dosage, or environmental factors are responsible fo

246 nd manipulation errors, and (4) detection of gene dosage over a wide dynamic range.

247 e female X chromosome is silenced to achieve gene dosage parity between the sexes.

248 strated previously that decreased HIF-1alpha gene dosage partially rescues both cardiac and lens defe

249 Gene dosage plays a critical role in a range of cellular

250 MicroRNAs (miRNAs) modulate gene dosage posttranscriptionally, and among these, the

251 Npc1+/- mice to determine if decreased Npc1 gene dosage predisposes to metabolic features associated

252 zation (aCGH), increasingly offer definitive gene dosage profiles in clinical samples.

253 Thus, increased gene dosage rather than specificity divergence of the CE

254 ice, we found that reduced ribosomal protein gene dosage recapitulates cardinal features of the 5q- s

255 genomic imprinting emerged as a monoallelic gene dosage regulatory mechanism of tightly interconnect

256 Altered gene dosage relationships are believed to contribute to

257 nscriptionally silenced to equalize X-linked gene dosage relative to XY males, a process termed X chr

258 rocess that is required to equalise X-linked gene dosage relative to XY males.

259 These results show there is a critical gene dosage requirement of functional Runx2 for the form

260 nstrate that a reduction of cyclooxygenase 2 gene dosage rescued the ovarian aging phenotype of the W

261 Activating Wnt signaling and reducing FGF gene dosage rescues gangliogenesis and innervation in bo

262 ors) to determine if expression patterns and gene dosage responses at the level of transcription are

263 An increase in histone gene dosage resulted in enhanced DNA damage sensitivity,

264 ry necessary for growth in woody tissues and gene dosage resulting in gene expression reconfiguration

265 ute to Rgg2/3 system induction, as decreased gene dosage results in decreased or absent induction.

266 )fB(+/-) mice were substantially reduced for gene dosage secondary to enhanced AP turnover.

267 (Asteraceae; sunflower family) [6] and with gene dosage sensitivity [8].

268 This highlights the gene dosage sensitivity of the pathway's effect on Sry l

269 tly expressed human genes, indicating global gene dosage sensitivity.

270 el that involves more fluid concepts such as gene dosage-sensitivity and tissue specificity.

271 t mCNVs give rise to most human variation in gene dosage-seven times the combined contribution of del

272 Altering tph-1 gene dosage showed that small changes in tph-1 expressio

273 Moreover, increased Rrm2 gene dosage significantly extends the life span of ATR m

274 hway abnormalities were either the result of gene dosage specific effects or the consequence of a glo

275 Taken together, the results show how gene dosage studies provide critical insights into the a

276 We used this model to perform a gene dosage study exploring the effects of the DeltaE mu

277 Increased DYRK1A gene dosage, such as occurs in Down syndrome, is known t

278 hese are alterations in gene products and in gene dosage that affect development and reproductive suc

279 large degree been focused on the changes in gene dosage that they generate and has neglected the eff

280 inactivation evolved to solve the problem of gene dosage, the purpose of genomic imprinting remains c

281 We found that diminished 22q11.2 gene dosage-the primary genetic lesion in 22q11.2 deleti

282 hat there are developmental process-specific gene dosage thresholds beyond which the phenotype worsen

283 Altering gene dosage through variation in gene copy number is a p

284 e progenitors is insensitive to reduced Sox9 gene dosage, thus explaining the normal organ size at bi

285 In order for gene dosage to be visible to natural selection, there mu

286 netic signaling pathways interact with 22q11 gene dosage to modulate the severity of cranial or cardi

287 Selection on relative gene dosage (to maintain proper stoichiometry among inte

288 st analysis of small RNA expression in plant gene dosage variants.

289 In contrast, gene dosage varied negatively with mean cortical thickne

290 22q11.2 gene dosage varied positively with intracranial volume,

291 ing cells, but ERAD became relevant when the gene dosage was affected, as demonstrated in heterozygou

292 sponse to changes in Ca(2)(+) channel Cav1.2 gene dosage was studied in adult mice.

293 As the regulatory loci result from extra gene dosage, we call them copy number expression quantit

294 By genetically manipulating APOE gene dosage, we demonstrate that decreasing human apoE l

295 g pathways that are susceptible to decreased gene dosage, we performed a genome-wide screen for haplo

296 NA) silencing (nucleolar dominance) and rRNA gene dosage, we studied a recently emerged (within the l

297 o X chromosomes in order to balance X-linked gene dosage with their male counterparts.

298 their two X chromosomes to equalize X-linked gene dosage with XY males in a process referred to as X-

299 ry views imprinting as a mechanism to change gene dosage, with imprinting evolving because of the dif

300 ated whether modulating adrenomedullin (Adm) gene dosage within tumor cells affects lymphangiogenesis