ライフサイエンスコーパス: gene drive

1 writing the changes introduced by an earlier gene drive.

2 argeting Ae. aegypti that rely on Cas9-based gene drives.

3 ls and control disease-carrying insects with gene drives.

4 Myc oncoproteins induce genes driving aerobic glycolysis, including lactate dehy

5 ly replace a harmful wild-type allele with a gene drive allele engineered to have desired functionali

6 organisms to study how a locally introduced gene drive allele spreads to replace the wild-type allel

7 We examine potential barriers to Semele gene drive and suggest molecular tools that could be use

8 The sensitivities of Gene drive and Xpert for the detection of smear-microsco

9 utionary strategies to control the spread of gene drives and reverse genomic changes.

10 we discuss the different types of engineered gene drives and their potential applications, as well as

11 Gene-driven and diverse types of phenotype-driven screen

12 etter molluscicides, new technologies (e.g., gene drive), and 'outside the box' strategies such as na

13 al-based mathematical model to simulate each gene drive approach in a variety of sub-Saharan African

14 Within its parameter space for success, each gene drive approach provides a tool for malaria eliminat

15 Here, we developed a CRISPR-Cas9-based 'gene drive array' platform to facilitate efficient genet

16 However, identification of genes driving association signals remains challenging.

17 For each targeted locus we observed a strong gene drive at the molecular level, with transmission rat

18 phage-like particles can transfer bacterial genes, driving bacterial evolution and promoting the eme

19 ere we consider the potential for RNA-guided gene drives based on the CRISPR nuclease Cas9 to serve a

20 A gene drive biases inheritance of a gene so that it incre

21 ice were generated using a Flag-tagged Smad4 gene driven by 180-bp fragment of the Mullerian inhibiti

22 the transcription of the luciferase reporter gene driven by a 124-base pair OPN promoter fragment con

23 logenin gene was recapitulated by a reporter gene driven by a 2.2-kilobase mouse amelogenin proximal

24 2, caused trans-activation of a CAT reporter gene driven by a 772 bp segment of the human COL1A2 prom

25 reatly stimulated activity of a CD4 reporter gene driven by a basic CD4 promoter and the CD4 enhancer

26 rkat cell line stably transfected with a tax gene driven by a cadmium-inducible promoter.

27 en transgenic events, containing the AmCYAN1 gene driven by a CMP promoter and the E. coli PMI gene d

28 e transient and stable expression of the p19 gene driven by a constitutive promoter as well as an eth

29 on the expression of the luciferase reporter gene driven by a constitutive ubiquitin promoter (UBI-Lu

30 A construct containing the bacterial LacZ gene driven by a fragment of the beta-PDE 5' flanking re

31 s of thymidine, or by coexpression of the TS gene driven by a heterologous promoter.

32 t-range plasmid that contained an intact aae gene driven by a heterologous tac promoter restored the

33 we generated transgenic mice with human GCIP gene driven by a liver-specific albumin promoter.

34 virus (rAAV) encoding the human alpha-gal A gene driven by a modified chicken beta-actin (CAG) promo

35 xpression of PKC-theta stimulated a reporter gene driven by a mouse Bcl-xL promoter.

36 ssed in Jurkat T lymphocytes with a reporter gene driven by a mutant serum response element, SRE.L, w

37 an amyloid beta precursor protein (APP) mini-gene driven by a platelet-derived (PD) growth factor pro

38 human placental alkaline phosphatase (hPAP) gene driven by a promoter containing a core ARE sequence

39 eporter line that harbors a LUCIFERASE (LUC) gene driven by a promoter that undergoes DNA methylation

40 used a mouse transgenic for a lacZ reporter gene driven by a RA response element (RAREhsplacZ) to id

41 a recombinant adenovirus containing the HERG gene driven by a Rous sarcoma virus (RSV) promoter.

42 transcription from a plasmid-based reporter gene driven by a SNAT2 genomic fragment containing the C

43 on (SP) cells by using a transgenic reporter gene driven by a stem cell enhancer.

44 plants expressing an isopentenyltransferase gene driven by a stress- and maturation-induced promoter

45 The ATFs can rapidly induce a single gene driven by a synthetic promoter in response to intro

46 ous study in D. melanogaster used a reporter gene driven by a testis-specific promoter to show that e

47 carrying the green fluorescent protein (GFP) gene driven by a ubiquitously expressing promoter.

48 or (PEDF) or an AAV2 vector containing a PS1 gene driven by a vascular endothelial-cadherin promoter.

49 rated in which a modified hydra beta-catenin gene driven by an actin promoter is continuously express

50 nsient expression of the luciferase reporter gene driven by an hMGMT promoter fragment containing the

51 2 also increased transcription of a reporter gene driven by an MEF-2-specific DNA element in a PI 3-k

52 line stably expressing a luciferase reporter gene driven by antioxidant response elements.

53 here was a strong expression of the reporter gene driven by AtG3Pp4 promoter in the roots, shoots, an

54 model generated through excision of the Nf2 gene driven by Cre expression under control of a tissue-

55 uced TCDD-dependent activation of a reporter gene driven by dioxin response elements.

56 driven by a CMP promoter and the E. coli PMI gene driven by either a CMP or Ubi promoter, were used t

57 Using a luciferase gene driven by either a PPAR response element or a DR-1

58 hibited IFN-induced expression of a reporter gene driven by either IFN-alpha/beta- or IFN-gamma-respo

59 for the expression of a chromosomal reporter gene driven by either RAG promoter.

60 d the expression patterns of the human gamma-gene driven by either the human or the galago gamma-prom

61 A WAKL4-green fluorescent protein fusion gene driven by either the WAKL4 native promoter or the 3

62 NF-kappaB in intact cells, and by a reporter gene driven by four NF-kappaB-binding elements.

63 ressed expression of the luciferase reporter gene driven by glycoprotein IX promoter in L-G cells but

64 -globin plasmids using a minimal beta-globin gene driven by hybrid promoter IHK (human ALAS2 intron 8

65 ons and express the stem cell leukemia (SCL) gene driven by its 5' enhancer.

66 hat expresses an extra copy of the mouse p53 gene driven by its endogenous promoter is utilized.

67 oramphenicol acetyl transferase (CAT) marker gene driven by its promoter in transgenic plants.

68 expression patterns of a luciferase reporter gene driven by lactase promoter regions in transgenic mi

69 Using the luciferase reporter gene driven by Mdm2-minimal promoter in p53 null cells,

70 ty and increased transcription of a reporter gene driven by multimerized GATA4-binding DNA elements.

71 f chloramphenicol acetyltransferase reporter gene driven by murine interferon A4 promoter in a transi

72 creases were seen with a luciferase reporter gene driven by tandem repeats of CRE and a CREB-specific

73 The transcription of a reporter gene driven by the -180 site was enhanced in normal T ce

74 Transfection assays, using a reporter gene driven by the 561 promoter, identified specific tyr

75 hat glucose-induced expression of a reporter gene driven by the A(2)GA(5) CLN3 regulatory sequences i

76 Accordingly, a reporter gene driven by the AG cis-element was able to respond to

77 ouse strain that expresses the LacZ reporter gene driven by the Ang-2 promoter.

78 and inhibited transcription from a reporter gene driven by the ASNS promoter following activation by

79 in suppressed the expression of the reporter gene driven by the AtPT1 promoter, and that of the nativ

80 genic (MAFIA) mice that express an inducible gene driven by the c-fms promoter for Fas-mediated apopt

81 x8 can activate the expression of a reporter gene driven by the c-RET promoter.

82 ingly activates a stably integrated reporter gene driven by the Ca2+/cAMP-responsive element of the h

83 Expression of a reporter gene driven by the CaMV 35S promoter is markedly reduced

84 boring the beta-glucuronidase (GUS) reporter gene driven by the cauliflower mosaic virus 35S (CaMV35S

85 the green fluorescent protein (GFP) reporter gene driven by the CMV promoter.

86 A second construct, containing a ZFN gene driven by the constitutive CsVMV promoter and an HP

87 n of the yellow fluorescent protein reporter gene driven by the CryR1 cis-element in Arabidopsis leaf

88 re, Cdc42V12 was able to activate a reporter gene driven by the cyclin E promoter in the absence of e

89 dCMV.CE) carrying the human carboxylesterase gene driven by the cytomegalovirus (CMV) promoter, infec

90 s expressing the beta-galactosidase reporter gene driven by the cytomegalovirus (CMV; control, n = 6)

91 A rescuing daf-9::GFP fusion gene driven by the daf-9 promoter is expressed in two he

92 With a luciferase reporter gene driven by the Dectin-1 gene promoter, the expressio

93 timulus increases the activity of a reporter gene driven by the Egr response element and that a domin

94 reporter constructs: the beta-glucuronidase gene driven by the GA-inducible Amy32b alpha-amylase pro

95 a transgenic mouse line harboring a reporter gene driven by the GelB promoter, we further show that i

96 ic rice grains containing the human lysozyme gene driven by the Glb promoter produced 3.7-fold more l

97 ation, expression of the luciferase reporter gene driven by the H-rev107 promoter decreased by 80% in

98 that transcription of a luciferase reporter gene driven by the heparanase promoter was significantly

99 adenoviral vector expressing a LacZ reporter gene driven by the hTERT core promoter and evaluated its

100 t that the adenovirus encoding the GFP/TRAIL gene driven by the hTERT promoter has potential applicat

101 n also inhibited transcription of a reporter gene driven by the human IRS-2 promoter that was transfe

102 induced expression of a luciferase reporter gene driven by the IFN-beta promoter and induced product

103 s, has no effect on expression of a reporter gene driven by the IL-4 promoter in mast cells.

104 NS5A induced transcription of a reporter gene driven by the IL-8 promoter, and the first 133 bp o

105 ssion of an attenuated diphtheria toxin (DT) gene driven by the ITF promoter; other cell lineages wer

106 asmid-borne chloramphenicol-resistance (cat) gene driven by the lac promoter.

107 ing the urokinase-type plasminogen activator gene driven by the major urinary protein promoter.

108 vitro methylation of the luciferase reporter gene driven by the mDOR promoter resulted in an inhibiti

109 specific, as expression of the lacZ reporter gene driven by the murine leukemia virus long terminal r

110 mbinatorial codes with a luciferase reporter gene driven by the myelin basic protein promoter define

111 sing its ability to transactivate a reporter gene driven by the myogenin promoter.

112 Expression of luciferase reporter gene driven by the Pi starvation-induced AtPT2 promoter

113 resulting in the expression of the cyclin D1 gene driven by the powerful enhancer of the immunoglobul

114 ltered expression of the luciferase reporter gene driven by the promoter from the heat-inducible gene

115 nt transfections using a luciferase reporter gene driven by the promoter region of Bcl-2 containing a

116 ion in a transgenic mouse of a LacZ reporter gene driven by the proximal 6.5 kb of the connexin 43 pr

117 rboring the human alkaline phosphatase (HAP) gene driven by the proximal 840 bp of a quail SMyHC3 pro

118 Using a reporter gene driven by the R2 regulatory element, we analyzed th

119 The expression of a reporter gene driven by the S. bayanus promoter was glucose-repre

120 abidopsis plants transformed with a reporter gene driven by the same promoter showed no abnormalities

121 ne plasmid and a beta-galactosidase reporter gene driven by the sigma32-dependent groE promoter on an

122 ue growth factor promoters and of a reporter gene driven by the Smad-binding element.

123 imulated expression of a luciferase reporter gene driven by the Stat3 promoter.

124 that express the firefly luciferase reporter gene driven by the stress-responsive RD29A promoter.

125 ulture, including ES cells, and also an EGFP gene driven by the strong CAG promoter for quick detecti

126 , CJ2-gD2, that contains 2 copies of the gD2 gene driven by the tetracycline operator (tetO)-bearing

127 constructed to express a firefly luciferase gene driven by the viral M3 promoter (M3FL).

128 hymidine kinase promoter-luciferase reporter gene driven by three tandem copies of the desmin MEF2 or

129 e made transgenic mice that express a marker gene driven by two candidate promoters, designated BC an

130 aling, transgenic mice carrying a luciferase gene driven by two estrogen response elements (ERE-lucif

131 ed by a more robust activation of a reporter gene driven by unfolded protein response activation upon

132 by employing mice transgenic for a reporter gene driven by various 5' deletions as well as site-spec

133 amplicon-6 vectors containing a GFP reporter gene driven by WT viral promoter or by promoter mutated

134 e introduced a construct carrying both a ZFN gene, driven by a heat-shock promoter, and its target in

135 of the 3' UTR of hsp 70 genes to a reporter gene, driven by different promoters, maintained a high l

136 t transgenic mice expressing the human B-myb gene, driven by the basal cytomegalovirus promoter, comp

137 eening purposes when the expression of a GFP gene, driven by the reactivation of endogenous stem cell

138 rpes simplex virus thymidine kinase reporter genes driven by a constitutive ubiquitin promoter into a

139 e were developed which carry cyclin D2 or D3 genes driven by a keratin 5 promoter.

140 ect on the expression of luciferase reporter genes driven by a variety of KSHV and heterologous promo

141 E (apoE)(-/-)/transgenic mice carrying LacZ genes driven by an endothelial TIE2 promoter.

142 n grafts using transgenic mice carrying LacZ genes driven by an endothelial TIE2 promoter.

143 of HTLV-I-transformed T cells by regulating genes driven by both kappaB and certain STAT enhancers.

144 Ideally, expression of therapeutic genes driven by cancer-specific promoters would only tar

145 of baculoviruses carrying viral or cellular genes driven by CMV immediate-early promoter.

146 intained modest activation of cleavage-stage genes driven by conventional promoters but did not activ

147 tors and transfection of luciferase reporter genes driven by CREB-responsive promoters.

148 Using transcriptional and splicing reporter genes driven by different promoters, we observed that Co

149 to investigate the transcription of reporter genes driven by each haplotype.

150 sp. red fluorescent protein (DsRed) reporter genes driven by either CaMV35S or intron-interrupted mai

151 n/Spm, DOPA activates expression of reporter genes driven by either the Dop promoter or sigma in tran

152 ene transfer vehicles for delivering foreign genes driven by mammalian promoters into human and mouse

153 iate TR-mediated transactivation of reporter genes driven by natural thyroid hormone response element

154 on of the endogenous Ntr-1 gene and reporter genes driven by NTR-1 promoter sequences by 3-4-fold.

155 An NF-kappaB-dependent subset of genes driven by oncogenic PI3K mutations was also identi

156 orescent protein and red fluorescent protein genes driven by promoters that are functional in maize (

157 H3 displacement differed between genes driven by promoters with 'open'/DPN and 'closed'/O

158 rexpression of TEF had no effect on reporter genes driven by SM22alpha, smooth muscle alpha-actin, or

159 of different spliced variants produced from genes driven by steroid hormone-dependent promoters.

160 vious work shows that expression of reporter genes driven by testis-specific promoters is considerabl

161 GLK genes driven by the Arabidopsis epidermal FIDDLEHEAD (FD

162 dermal and endodermal expression of reporter genes driven by the Bix4 promoter in transgenic Xenopus

163 g luciferase and beta-galactosidase reporter genes driven by the Col1a2 enhancer/promoter and the CTG

164 cted with full-length PKC-alpha or PKC-theta genes driven by the ecdysone promoter.

165 opment, and can be visualized using reporter genes driven by the GLABRA (GL)2 promoter as markers.

166 Hepa cells stably-transfected with reporter genes driven by the MT-I promoter suggested two in vivo

167 Concurrent transactivation of reporter genes driven by the prostate-specific antigen promoter o

168 The expression of reporter genes driven by the same human elongation factor 1alpha

169 tivator inhibitor 1 promoter and of reporter genes driven by the SBE and the related CAGA element.

170 lyse experimentally stochastic expression of genes driven by the Synechococcus elongatus circadian cl

171 The expression of exogenous genes driven by the TBG promoter demonstrates to be much

172 0 induced the ectopic expression of reporter genes driven by the wild-type unc-25 and unc-47 promoter

173 Genes driven by these repeat-containing promoters show s

174 actions among transcription factors, the gap genes, driven by maternal inputs.

175 ntranslated regions of known disease-causing genes, driven by SOD1, TARDBP, FUS, VCP, OPTN and UBQLN2

176 The MYB80 homolog genes, driven by the AtMYB80 or their respective promote

177 Induction of reporter genes, driven by truncated Ifit1 promoters, identified t

178 amplifications and codeletions and delineate genes driving cancer metabolism from those that are neut

179 RNA-guided gene drives capable of spreading genomic alterations mad

180 focused on the mechanisms by which Rb family genes drive cell cycle exit following DNA damage inducti

181 observed in human cancers, proposes that the genes driving cell proliferation induce DNA replication

182 tion was associated with the upregulation of genes driving ceramide biosynthesis, an event dependent

183 ension of sensory experience based solely on gene-driven changes in receptor organization.

184 tor genes, a marker gene, and the autonomous gene-drive components are introgressed into approximatel

185 of regulatory sequence from the murine IL-2 gene drives consistent expression of a green fluorescent

186 ver, an accidental or premature release of a gene drive construct to the natural environment could da

187 on, and inserted into each locus CRISPR-Cas9 gene drive constructs designed to target and edit each g

188 For example, RNA-guided gene drives could potentially prevent the spread of dise

189 xistence of many yet-to-be discovered cancer genes driving CRC development, as well as other human ca

190 ating gene drive technologies, highlight new gene drive designs that might achieve better outcomes, a

191 pecific genes and repression of pluripotency genes drives differentiation of embryonic stem cells (ES

192 albicans haploids, each carrying a different gene drive disabling a gene of interest, we are able to

193 somes to collapse a mosquito population, and gene drive disrupting a fertility gene and thereby achie

194 rest in environmental releases of engineered gene drives due to recent proof of principle experiments

195 ion: 'selected expression regulators' (SERs)-genes driving dysregulated transcriptional programs in c

196 Using a luciferase gene driven either by a PPAR response element or by a DR

197 eporter constructs containing the luciferase gene driven either by E-selectin or interleukin (IL)-8 p

198 discuss growing evidence that implicates AD gene-driven ELN disruptions as not only the antecedent p

199 node controlling translational activation of genes driving EMT and ultimately tumour progression.

200 investigating the rates and patterns of new gene-driven evolution of GGI networks in the human and m

201 should enable the development of safe CRISPR gene drives for diverse organisms.

202 icies regarding the safety and regulation of gene drives for the manipulation of wild populations.

203 ted the IFN-mediated induction of a reporter gene driven from an ISRE-containing promoter.

204 olid tumors for specific silencing of target genes driving growth and/or metastasis.

205 netic mechanisms for limiting or eliminating gene drives have been proposed and/or developed, includi

206 Gene drives have the potential to rapidly replace a harm

207 t a 12.4-kilobase region of the mouse villin gene drives high level expression of two different repor

208 By delineating expression outlier genes driven in cis by CNAs, we identified putative canc

209 As is dynamically induced at most of the key genes driving innate immunity and inflammation.

210 This, coordinated with induction of genes driving intestinal differentiation, may be require

211 We argue that "balanced gene drive" is a sufficient explanation for the trend th

212 Controversy exists as to whether viral genes drive it directly or less directly orchestrate the

213 identified an enhancer upstream of the Wnt9a gene driving joint-specific expression in transgenic rep

214 We predicted genes driving lineage divergence and explored their expr

215 Our predicted genes driving lineage divergence provide good starting p

216 strongly point to FAT1 as a tumor suppressor gene driving loss of chromosome 4q35, a prevalent region

217 idered a symbol of maleness, as it encodes a gene driving male sex determination, Sry, as well as a b

218 We also identified six genes driving malignant tumor progression and a new huma

219 Gene drives may be capable of addressing ecological prob

220 method of disease prevention but requires a gene drive mechanism to spread these traits to high freq

221 CI is a gene-drive mechanism impacting population structure(6) a

222 ly to be lost from the environment; however, gene drive mechanisms enhance the invasiveness of introd

223 o analyze the loss probabilities for several gene drive mechanisms, including homing endonuclease gen

224 pment of CRISPR-Cas9 reagents as a source of gene drive, more advanced technologies at driving malene

225 Gene drive mosquitoes constitute a promising set of tool

226 low copy-number gain of one or more of these genes drives neoplasia is not known.

227 NST progression useful for identifying novel genes driving neurofibroma and MPNST pathogenesis.

228 s that aid in the perpetuation of MLL fusion gene driven oncogenic programs are being defined, presen

229 To identify the genes driving osteosarcoma development and metastasis, w

230 rize below some key insights from the recent gene-driven phase of research on Werner syndrome, a heri

231 ew analyses are needed as existing models of gene drive primarily focus on nonseasonal or nonspatial

232 llowed by proper regulatory integration of a gene drive rapid evolution of bacterial pathogens.

233 However, single gene-driven recombinase lines mark relatively broad and

234 tion; inappropriate expression of HIF target genes drives renal carcinogenesis.

235 Promoters for several PPK genes drove reporter gene expression in the larval and a

236 aborators, we show that socially responsible gene drives require 0.5 < s < 0.697, a rather narrow ran

237 of genomic tools and products (e.g., CRISPR, gene drives, RNAi, synthetic biology, and genetically mo

238 ose from the Xenopus laevis mespb (Xl-mespb) gene drive segmental expression in transgenic zebrafish.

239 that includes transgenic females results in gene drive since females carrying the allele are favored

240 These results highlight how the individual genes driving speciation can be embedded within an activ

241 the development of HE-based gene editing and gene drive strategies in Ae. aegypti, and confirm the ut

242 nts for successful deployment of a HEG-based gene drive strategy can be satisfied in a model dipteran

243 Here, we show that any transposon-mediated gene drive strategy must have an exceptionally low rate

244 ty in vector population dynamics facilitates gene drive success compared with nonseasonal analyses.

245 If gene drives successfully eradicated these invasive popul

246 ypes or to what extent the same or different genes drive such convergence.

247 ependent rearrangement of endogenous TCRbeta genes, driving surface expression of novel TCRs.

248 creation of a synthetic threshold-dependent gene drive system, designated maternal-effect lethal und

249 sequences show promise as part of a TE-based gene drive system.

250 CRISPR)-associated protein 9 (Cas9)-mediated gene-drive system in the Asian malaria vector Anopheles

251 ctor control strategies utilizing engineered gene drive systems are being developed as a means of rep

252 organisms also suggests that reprogrammable gene drive systems based on these nucleases may be capab

253 ant mosquito strains make urgent research of gene drive systems capable of moving effector genes into

254 een invasiveness and containment for the six gene drive systems currently being considered for the co

255 as9 endonuclease constructs that function as gene drive systems in Anopheles gambiae, the main vector

256 We report the efficacy of CRISPR-Cas9 gene drive systems in wild and laboratory strains of the

257 Gene drive systems that enable super-Mendelian inheritan

258 ic approach to developing safe and effective gene drive systems that includes defining the requiremen

259 Consequently, there is also interest in gene drive systems that, while strong enough to bring ab

260 Interest in developing gene drive systems to control invasive species is growin

261 e the confinement properties of a variety of gene drive systems.

262 simplify the evaluation of novel Cas9-based gene drive systems.

263 ting human malaria parasites and to generate gene-drive systems capable of introgressing the genes th

264 he complementary mouse genetic approaches of gene-driven, targeted mutagenesis and phenotype-driven,

265 P007280, meets the minimum requirement for a gene drive targeting female reproduction in an insect po

266 accidental spread posed by self-propagating gene drive technologies, highlight new gene drive design

267 other emerging techniques, such as advancing gene-drive technologies, are summarized, as well as curr

268 that an intronic promoter within the GLEPP1 gene drives the expression of the PTP-oc in a cell type-

269 t, but not a 0.6-kb fragment, of the mE-RABP gene driving the chloramphenicol acetyltransferase (CAT)

270 These genes drive the complex and delicately timed sequence of

271 demonstrate that enhancers within bystander genes drive the expression of genes such as Otx and Isle

272 Mutated protein-coding genes drive the molecular pathogenesis of many diseases,

273 with the promoters of both the Myf5 and MyoD genes drives the de novo myogenesis in satellite cells e

274 the rapid induction of these circadian clock genes drives the resetting process.

275 analyses designed to highlight the specific genes driving the aggregate signal, we confirmed associa

276 and the activation of increasing numbers of genes driving the chosen developmental direction.

277 e also developed a procedure for identifying genes driving the concordance of the genomics profiles a

278 ind a significant delay in the expression of genes driving the generation only of later- but not earl

279 e of numerous oncogenes and tumor suppressor genes driving the genesis and progression of this lethal

280 Period1 (Per1) is one of several clock genes driving the oscillatory mechanisms that mediate ci

281 er, the role of genomic changes in metabolic genes driving the tumour metabolic shift remains to be e

282 tem genetics approach identified lung tissue genes driving the variation in lung function and suscept

283 tion, in addition to those in protein-coding genes, drove the evolution of uniquely human biological

284 Engineered gene drives - the process of stimulating the biased inhe

285 p2c to triply occupied sites at TSC-specific genes, driving their expression.

286 To identify the genes driving this extensive phenotypic variation, we pe

287 to create, streamline and improve synthetic gene drives, this is rapidly changing.

288 ential approaches to disease control utilize gene drive to spread anti-pathogen genes into the mosqui

289 nuclease-based homing reaction as a form of gene drive to spread those genes through target populati

290 articipant, and compared the accuracy of the Gene drive to that of the Xpert MTB/RIF assay using M. t

291 e findings could expedite the development of gene drives to suppress mosquito populations to levels t

292 the additional loss of one copy of the Fbxw7 gene drives tumor development in a range of epithelial t

293 However, AP-1-regulated genes driving tumor induction are yet to be defined.

294 of the pushed wave can be stopped by making gene drives uniquely vulnerable ("sensitizing drive") in

295 tion found in bird beaks to investigate what genes drive vertebrate facial morphogenesis.

296 e molecular mechanisms by which the 1918 PB2 gene drives viral pathogenicity.

297 sgene's fitness cost and the efficacy of the gene drive will be more crucial than any evolutionary ad

298 ushed wave" regime, the spatial spreading of gene drives will be initiated only when the initial freq

299 A GUS-reporter gene driven with the putative LeMAN5 promoter (-543 to +

300 ities for the tuberculosis case detection of Gene drive, Xpert, and smear microscopy were 45.4% (95%