ライフサイエンスコーパス: gene duplication

1 of genes out of a gene block, gene loss, and gene duplication.

2 espite retention for millions of years after gene duplication.

3 ctionalized genes via whole-genome or tandem gene duplication.

4 A viruses to acquire drug resistance through gene duplication.

5 eo- and subfunctionalization in evolution by gene duplication.

6 sification of land plants, predominantly via gene duplication.

7 ly contribute to functional divergence after gene duplication.

8 cally improving the efficacy of evolution by gene duplication.

9 lost along the lineage leading to SWI5 after gene duplication.

10 evolutionary events, such as speciation and gene duplication.

11 elength-sensitive (SWS1) opsin genes without gene duplication.

12 nsion glaucoma in human patients with a TBK1 gene duplication.

13 alog, HasB2, which most likely resulted from gene duplication.

14 ds in mammalian genomes are formed by tandem gene duplication.

15 creasing network complexity, in this case by gene duplication.

16 f genes rather than the canonical process of gene duplication.

17 (RdRP) that probably emerged as a result of gene duplication.

18 wed evidence for sequence adaptation through gene duplication.

19 Rab binding sites that must have evolved via gene duplication.

20 gleton genes, and the evolutionary impact of gene duplication.

21 idence for dN/dS (omega) variation following gene duplications.

22 id genome, specifically the impact of single gene duplications.

23 ignores evidence that LEAFY evolves through gene duplications.

24 e distributions and phylogenetic analyses of gene duplications.

25 A. thaliana paralogs result from independent gene duplications.

26 h genome-level changes such as mutations and gene duplications.

27 onships from species divergences and ancient gene duplications.

28 different modes such as segmental and single-gene duplications.

29 ly reconstruct the frequency and location of gene duplications.

30 Transposed gene duplication, a specific form of single-gene duplica

31 h wheat-specific inter- and intrachromosomal gene duplication activities that are potential sources o

32 Horizontal gene transfer and gene duplication allowed the stepwise acquisition of vir

33 ructure divergence between paralogs, but not gene duplication alone, leads to a significant reduction

34 ntified in vertebrates, which originate from gene duplication, alternative splicing or post-translati

35 that the kinetoplastids pathways evolved via gene duplication and acquisition of an FMN-binding domai

36 Gene duplication and alternative splicing are important

37 Despite research indicating that gene duplication and alternative splicing are negatively

38 arding the evolutionary relationship between gene duplication and alternative splicing, two processes

39 d as such highlight the relationship between gene duplication and alternative splicing.

40 s occurs through complex processes including gene duplication and an alternative processing of scramb

41 Gene duplication and convergent evolution within a genom

42 and exhibit surprisingly variable levels of gene duplication and directional selection that correlat

43 These results provide an illustration of how gene duplication and divergence can generate potential f

44 ns with novel functions arise primarily from gene duplication and divergence events.

45 ave undergone subfunctionalization following gene duplication and divergence of maize, sorghum, and r

46 over the last 100 million years that include gene duplication and divergence, gene loss, evolution of

47 ct homodimeric ancestor through a process of gene duplication and diversification; however molecular

48 CU2 and MICU3, each of which likely arose by gene duplication and exhibits distinct patterns of organ

49 This relationship most likely evolved by gene duplication and functional divergence (i.e. neofunc

50 m an ancestral (betaalpha)(4)-half-barrel by gene duplication and fusion.

51 tonate tautomerase-like ancestor followed by gene duplication and fusion.

52 models for eukaryotic species allow for only gene duplication and gene loss or only multispecies coal

53 (codon usage optimality and gene expression, gene duplication and genetic dispensability, stem cell d

54 Thus, the gene duplication and heteropolymerization of chloroplast

55 hat subsequently increased in complexity via gene duplication and horizontal gene transfer.

56 l complexes of two types of subunits through gene duplication and integration of SEPALLATA proteins j

57 f the active AdoMetDC enzyme that evolved by gene duplication and is found only in the trypanosomatid

58 What constraints are there on gene duplication and lateral gene transfer?

59 Additionally, Scaptomyza has experienced gene duplication and likely positive selection in paralo

60 ion methods consider discordance only due to gene duplication and loss (and sometimes horizontal gene

61 o substitutions, evolutionary events such as gene duplication and loss (as well as horizontal transfe

62 Gene duplication and loss are important processes in the

63 Gene duplication and loss are major sources of genetic p

64 ion of the Nup84 complex through a series of gene duplication and loss events.

65 Thus, regulatory evolution coupled with gene duplication and loss generated leaf shape diversity

66 ew probabilistic model, DLCoal, that defines gene duplication and loss in a population setting, such

67 Our study revealed high rates of CYP76C gene duplication and loss in Brassicaceae, suggesting th

68 We discuss how gene duplication and mutations that selectively stabiliz

69 used by CLPs, particularly into the role of gene duplication and neofunctionalisation in lifecycle e

70 r plants, pushing the date of the underlying gene duplication and neofunctionalization of the ancestr

71 nthesis of 3UFA SPCs in M. sexta lineage via gene duplication and neofunctionalization, whereas MsexD

72 ve been recruited from the sterol pathway by gene duplication and neofunctionalization.

73 enes were derived primarily from small-scale gene duplication and preserved in plant genomes and to d

74 Our results illustrate how gene duplication and sub-functionalization shape the wor

75 This suggests that gene duplication and subsequent diversification of funct

76 within existing gene families as a result of gene duplication and subsequent diversification.

77 g processes (e.g. horizontal gene transfers, gene duplication and subsequent neofunctionalization) wi

78 mainly caused by the eudicot-shared ancient gene duplication and subsequent species-specific segment

79 we investigate the mechanistic link between gene duplication and the emergence of new nonendosymbiot

80 ds of photoreceptors and help to explain how gene duplication and the formation of rod-specific prote

81 s via sequence evolution processes involving gene duplication and translocation.

82 the KIR gene system have been diversified by gene duplication and unequal crossing over, thereby gene

83 O evolved in the Brassicaceae family through gene duplication and was lost in A. thaliana, contributi

84 of genome organization that implicate local gene duplication and, to a lesser extent, single gene tr

85 While whole gene duplications and deletions are relatively well-stud

86 al brain disorders have been associated with gene duplications and deletions that serve to increase o

87 parative analysis reveals that high rates of gene duplications and functional diversifications might

88 lt of multiple evolutionary events including gene duplications and horizontal gene transfers.

89 reconciliation method that accurately infers gene duplications and losses in the presence of ILS, and

90 fficiently models horizontal gene transfers, gene duplications and losses, and uses a statistical hyp

91 t mechanism underlying PMP22-RAI1 contiguous gene duplications and provides further evidence supporti

92 frequent errors in recombination and lead to gene duplications and structural chromosome changes that

93 cs, including adaptive protein evolution via gene duplications and the emergence of novel regulatory

94 s, the p200 cluster, which arose by repeated gene duplications and which encodes a large family of hi

95 NF genes resulted largely from less frequent gene duplications and/or a higher rate of gene loss afte

96 Dicer and Rnt1, evolved through a series of gene-duplication and gene-loss events to generate the va

97 contain highly related paralogs generated by gene duplication, and functional divergence is generally

98 ion is an RNA-mediated mechanism to generate gene duplication, and is believed to play an important r

99 Gene families expand by gene duplication, and resulting paralogs diverge through

100 Here, we compared evolutionary rates, gene duplication, and selective patterns of genes involv

101 bacterioplankton have smaller genomes, fewer gene duplications, and are depleted in guanine and cytos

102 le-genome, segmental, tandem, and individual-gene duplications, and the emerged redundant paralogs wo

103 ologous genes, the formation of new genes by gene duplications, and the recruitment of genes from div

104 Gene duplications are a major source of evolutionary inn

105 Gene duplications are an important factor in plant evolu

106 It has been believed that the RNASE1 gene duplications are correlated with the plant-feeding

107 osophila, theoretical models that posit that gene duplications are immediately beneficial and fixed b

108 This becomes a crucial advantage when gene duplications are rare.

109 oNEET (CISD1) and NAF-1 (CISD2), emerged via gene duplication around the origin of vertebrates.

110 s, and highlights the putative importance of gene duplications as an evolutionary mechanism in dinofl

111 uantify whole genome duplications and single gene duplications as sources of TF family expansions, im

112 SmTK is derived from gene duplication, as are all known trematode TKs.

113 Most models of gene duplication assume that the ancestral functions of

114 an ancestral 3-ketosteroid receptor through gene duplication at the time when myelin appeared in jaw

115 work illustrates how retrotransposition and gene duplication can favour the emergence of novel metab

116 underscore how mechanisms other than tandem gene duplication can result in paralogous gene clusterin

117 An integrated view of various modes of gene duplication can supplement the traditional gene tre

118 Gene duplications can contribute significantly to the ev

119 Specific gene duplications can enable double-stranded DNA viruses

120 Gene duplications can facilitate adaptation and may lead

121 We have previously shown that LMNB1 gene duplications cause autosomal dominant leukodystroph

122 After gene duplication, changes in subcellular localization re

123 We identified 13 gene duplications coinciding with the species-specific g

124 dergone massive small-scale interchromosomal gene duplications compared to other grasses.

125 h show no patterns of enrichment, suggesting gene duplications contributed to domestication traits.

126 hematical phylogenetics, we demonstrate that gene duplications convey meaningful phylogenetic informa

127 gene duplication, a specific form of single-gene duplication, 'copies' a gene from an ancestral chro

128 Long-standing debates on the evolution of gene duplications could be settled by determining the re

129 Gene duplication (D), transfer (T), loss (L) and incompl

130 a repeated alpha-helical core, indicative of gene duplication despite lack of sequence similarity bet

131 ith GST classes suggest that TDR1 evolved by gene duplication, diversification, and gene fusion; a co

132 ion of new genes, via horizontal transfer or gene duplication/diversification, has been the dominant

133 volutionary scenario that implies the fewest gene duplications, duplications and losses, or deep coal

134 Gene silencing induced by matA gene duplication emerges as a specific feature associate

135 land types were not necessarily coupled with gene duplication, even though silk-specific genes belong

136 To study the processes that followed this gene duplication event and gave rise to HSS, we identifi

137 aldolase LacD.1 likely originated through a gene duplication event and was adapted to a role as a me

138 These domains are very similar, suggesting a gene duplication event during evolution.

139 over 550 million years ago as a result of a gene duplication event followed by loss of Cu(+) transpo

140 hin the lineage of the Boraginales, only one gene duplication event gave rise to HSS.

141 Our findings show that a gene duplication event permitted the functional speciali

142 This implies that the gene duplication event preceding primate speciation was

143 rgeted sHsps that have emerged from a recent gene duplication event resulting from the ongoing divers

144 s and probably evolved independently after a gene duplication event that occurred early in vertebrate

145 Here, we report a gene duplication event that yielded another outcome--the

146 copy was successfully recruited as HSS, the gene duplication event was followed by phases of various

147 tionary history due to local and large-scale gene duplication events and gene losses.

148 well-established evolutionary principle that gene duplication events discriminate paralogous from ort

149 Gene duplication events exert key functions on gene inno

150 efore likely to be as important as ancestral gene duplication events for generating compositionally d

151 tematically estimate recent lineage specific gene duplication events in Arabidopsis thaliana and furt

152 Four independent gene duplication events in the families of superfamily M

153 Gene duplication events may lead to the emergence of nov

154 Gene duplication events within the species resulted in t

155 hout plant evolution; but various genome and gene duplication events, which occurred during plant evo

156 a, beta and gamma, which originated from two gene duplication events.

157 ransfer events in addition to speciation and gene duplication events.

158 The proportions of the CsDof family genes, duplication events, chromosomal locations, cis-el

159 including physically clustered genes, tandem gene duplication, expression sub-functionalization, and

160 azoan globins, it is likely that neuroglobin gene duplication followed by co-option and subfunctional

161 evolution of novel gene function is through gene duplication followed by evolution of a new function

162 n, mouse, and zebrafish, we demonstrate that gene duplication followed by exon structure divergence b

163 By studying teleost fish, we find that gene duplication followed by exon structure divergence b

164 are often lineage-specific and derived from gene duplication followed by functional divergence.

165 82D2 might have evolved from SbCYP82D1.1 via gene duplication followed by neofunctionalization, where

166 The process of gene duplication followed by sequence and functional div

167 that CaPIMT2 has most likely evolved through gene duplication, followed by subfunctionalization to sp

168 s originated through a number of independent gene duplications from an ancestral metazoan selenoprote

169 g a drastic remodeling of CDC13 that entails gene duplication, fusion, and functional specialization.

170 nd ensuing prevalence has been attributed to gene duplications, fusion events, and subsequent evoluti

171 Gene duplications generate new genes that can acquire si

172 Gene duplication has been considered to increase genetic

173 Gene duplication has been proposed to drive the evolutio

174 3 may regulate gene activity are unclear and gene duplication has hampered an analysis of H3.3 functi

175 pressin from a single ancestor peptide after gene duplication has stimulated the development of the v

176 nes to support pheromone perception and that gene duplications have played an important role in the m

177 We propose that UV and LW opsin gene duplications have restored the potential for trichr

178 ization of pre-existing genes, notably after gene duplication, have been extensively described.

179 reconcile the two by postulating speciation, gene duplication, horizontal gene transfer and gene loss

180 n by evolutionary events such as speciation, gene duplication, horizontal gene transfer and gene loss

181 This model uses evidence from gene duplications, horizontal transfers, and gene losses

182 e, the general validity of the adaptation by gene duplication hypothesis remains uncertain.

183 ighlights an interesting example of a tandem gene duplication in Arabidopsis, helps to explain the ra

184 tRNA(Gln) for protein synthesis, evolved by gene duplication in early eukaryotes from a nondiscrimin

185 sue-specific gene expression and the role of gene duplication in functional novelty, but its potentia

186 tantly related species and the importance of gene duplication in generating novel H3K27me3 profiles.

187 tudies confirm the pathogenicity of the TBK1 gene duplication in human glaucoma and suggest that exce

188 The Robo family has expanded by gene duplication in insects; robo2 and robo3 exist as di

189 g proteins, which have arisen from extensive gene duplication in M. xanthus and related species.

190 lts provide genomic evidence for the role of gene duplication in organismal adaptation and are import

191 After gene duplication in rice, individual genes encode protei

192 ocesses such as selection, recombination and gene duplication in shaping MHC loci among amphibian lin

193 f multiple angiosperm genomes has implicated gene duplication in the expansion and diversification of

194 Third, local gene duplication in the pericentromeric region is reduce

195 ic gene expression in keeping with a role of gene duplication in the promotion of diversification and

196 esting that disease acceleration by the Tlr7 gene duplication in this model is mediated by type I IFN

197 We find that successive rounds of gene duplications in legumes have shaped tissue and deve

198 ent role of transcription factors and tandem gene duplications in morphological evolution.

199 pathway, with neofunctionalization following gene duplications in the CYP76AD1 and DODA lineages.

200 We found an excess of gene duplications in the East African lineage compared t

201 levant to explain the long-term evolution of gene duplications in this species.

202 Gene co-option, usually after gene duplication, in the evolution of development is fou

203 eview, we survey the current knowledge about gene duplication, including gene duplication mechanisms,

204 es have been shaped by extensive large-scale gene duplications, including an approximately 58 million

205 Also, our simulations show that gene duplications increase the frequency of ILS, further

206 amework also reveals that different modes of gene duplication influence the extent to which paralogou

207 ses that lead to the stable incorporation of gene duplications into the genome is important both beca

208 Gene duplication is a fundamental process in genome evol

209 Gene duplication is a key source of genetic innovation t

210 Gene duplication is a major evolutionary force driving a

211 Gene duplication is a primary means to generate genomic

212 lication (WGD) has been recurring and single-gene duplication is also widespread in angiosperms.

213 Gene duplication is an important evolutionary mechanism

214 Gene duplication is an important mechanism for adding to

215 Gene duplication is an important mechanism for the origi

216 Tandem gene duplication is an important mutational process in e

217 Gene duplication is arguably the most significant source

218 Gene duplication is believed to play a major role in the

219 Evolution by gene duplication is generally accepted as one of the cru

220 single-locus gene, the waiting time until a gene duplication is incorporated goes down as population

221 experiments using G-NEST confirm that tandem gene duplication is the primary driver of non-random gen

222 Gene duplication is widely believed to facilitate adapta

223 After gene duplication, it is unclear whether changes in the r

224 ic material through various means, including gene duplication, lateral gene transfer from bacteria th

225 sfers from prokaryotes and that expansion by gene duplication led to the functional diversification o

226 pipeline can model gene sequence evolution, gene duplication-loss, gene transfer and multispecies co

227 that exon structure evolution subsequent to gene duplication may be a common substitute for alternat

228 a reveal that subfunctionalization following gene duplication may be important in the maintenance and

229 One manner in which alternative splicing and gene duplication may be related is through the process o

230 ults suggest that the initial event of EPSPS gene duplication may have occurred because of unequal re

231 Although gene duplication may increase the fitness of the involve

232 Gene duplication may provide a way for poxviruses and ot

233 knowledge about gene duplication, including gene duplication mechanisms, the potential fates of dupl

234 In contrast to the classic gene duplication model, we find that a common mode of ac

235 can be also used for integrative analysis of gene duplication modes for a genome and to annotate a ge

236 d to annotate a gene family of interest with gene duplication modes.

237 of KNOX-interacting BELL proteins, in that a gene duplication occurred after divergence of the two gr

238 ss a single phytochrome, whereas independent gene duplications occurred within mosses, lycopods, fern

239 Gene duplication occurs via different modes such as segm

240 Here we present how a gene duplication of a periplasmic binding protein in a m

241 Eci3 specifically evolved in rodents after gene duplication of Eci2.

242 rigolactone recognition can evolve following gene duplication of KAI2.

243 yltransferase that is the result of a recent gene duplication of PRDM9.

244 a three-step process initiated by ancestral gene duplication of the original BspUPG1 locus, followed

245 , and WGDs show lower divergence than single-gene duplications of similar Ks levels.

246 s revealed effects of species-specific whole-gene duplication on gene expression.

247 To gain insight into the consequences of gene duplications on the expansion and diversification o

248 results highlight the major impact of single gene duplications on the wheat gene complement and confi

249 se novel biosynthetic pathways originate via gene duplication or by functional divergence of existing

250 nd we found no evidence of parasite-specific gene duplication or expansion.

251 ely related Streptomyces can be explained by gene duplication or lateral acquisition, and the former

252 increased alpha-synuclein expression due to gene duplication or triplication can cause familial PD,

253 We argue that gene duplication placed old, cold genes and communities

254 Gene duplications play a key role in the emergence of no

255 Gene duplication plays an important role in the origin o

256 oles of functional promiscuity, gene dosage, gene duplication, point mutations, and selection pressur

257 ich Rcr3 and Pip1 diverged functionally upon gene duplication, possibly driven by an arms race with p

258 One prediction of the classic Ohno model of gene duplication predicts that new genes form from the a

259 indicate that Cdc13B probably arose through gene duplication prior to Candida speciation.

260 However, endosymbiosis events and gene duplications provide some additional information th

261 A new study shows how gene duplication provides a potential source of antagoni

262 these loci had an eventful history involving gene duplications, rearrangements, deletions, and horizo

263 Consistent with functional divergence after gene duplication, recent studies have shown accelerated

264 analysis unravels lineage-specific bursts of gene duplications related to the emergence of specialize

265 sabA gene duplication resulted in increased SabA protein prod

266 ggests that gamma(2) originated from ancient gene duplication, resulting in divergent evolution of fu

267 Gene duplication results in two identical paralogs that

268 imately half of the roughly 500 new complete gene duplications segregating in the GDL lead to signifi

269 phylogenetic analysis, chromosome location, gene duplication status, gene structure and conserved mo

270 g a suicide vector (which does not result in gene duplication) still results in growth and developmen

271 tiple mechanisms, including lineage-specific gene duplication, subfunctionalization, neofunctionaliza

272 generate evolutionary novelties not based on gene duplication/subfunctionalization but by interaction

273 A distinct disorder results from MECP2 gene duplication, suggesting that therapeutic approaches

274 hat IRE1 is amplified at mucosal surfaces by gene duplication suggests an important role for IRE1 in

275 includes adaptive processes before and after gene duplication that lead to multifunctional proteins,

276 the positive selection of the ancient PAPhy gene duplication that lead to the creation of the PAPhy_

277 efects associated with TBX1 deletion and the gene duplication that leads to 22q11.2DS.

278 ese genes are derived from an ancient tandem gene duplication that likely predates the radiation of t

279 e ancient two-paralogue complex because of a gene duplication that was followed by loss in each daugh

280 However, we also found that six of the nine gene duplications that are fixed or close to fixation in

281 Relocation was accompanied by gene duplications that occurred in most starch-related g

282 sed, a software package to detect transposed gene duplications that occurred within different epochs,

283 rift treatment takes into account that after gene duplication the prevailing case upon which selectio

284 e the evolution of specialized enzymes after gene duplication, the evolution of specialized cell type

285 non-syntenic genes and a high rate of tandem gene duplications, the latter of which have given rise t

286 This indicates that, after arising through gene duplication, they have evolved to enable partly dif

287 An increase in alpha-synuclein levels due to gene duplications/triplications or impaired degradation

288 r evolution of transcription factors without gene duplication, using LEAFY as an archetype.

289 Further, the majority of gene duplications was placed after the divergence of the

290 One extra dose of the TBK1 gene (duplication) was detected in 3 normal-tension glau

291 understanding of an ancient human U1A/U2B'' gene duplication, we show that the last common ancestor

292 s drives the fixation and diversification of gene duplications, we have analyzed Cyp12d1 and Cyp12d3,

293 rom two CMT1A pedigrees with confirmed PMP22 gene duplication were studied.

294 Three previously unidentified gene duplications were detected, where two sequences rec

295 This implies that the gene duplication which gave rise to these paralogs occur

296 Unlike small-scale gene duplications, whole-genome duplications (WGDs) copy

297 understanding the mechanisms and impacts of gene duplication will be important to future studies of

298 se evolutionary constraint has relaxed after gene duplication with a likelihood-ratio test that can a

299 /7 in shaping leaf diversity and link tandem gene duplication with differential gene expression in th

300 Instead, gene duplication with divergence of one paralog and weak