ライフサイエンスコーパス: gene function

1 ion is necessary to make strong claims about gene function.

2 etic variants lead to increased or decreased gene function.

3 reens are a powerful tool for assessments of gene function.

4 stage suggests some of its significance for gene function.

5 for variant interpretation and understanding gene function.

6 d enable access to an underexplored space in gene function.

7 traditionally thought to disrupt the entire gene function.

8 kouts within a viable organism can inform on gene function.

9 reased the sensitivity for associating novel gene function.

10 ction studies are fundamental for dissecting gene function.

11 and provides an efficient tool for assessing gene function.

12 use of insertional mutants for the study of gene function.

13 cells represents a powerful method to study gene function.

14 176,000 are predicted to result in a loss of gene function.

15 e targeted gene facilitating the analysis of gene function.

16 instrumentation in their quest to understand gene function.

17 virus strains can be exploited to elucidate gene function.

18 hey represent hypomorphic alleles or abolish gene function.

19 and cell therapies or fundamental studies of gene function.

20 lic exchange is a powerful approach to probe gene function.

21 to maternal effects or failure to eliminate gene function.

22 mbinational "safeguard" control of essential gene function.

23 eactivation of both exogenous and endogenous gene function.

24 iated genes based on cell type of origin and gene function.

25 nerating a comprehensive resource of meiotic gene function.

26 probability of a mutation being damaging to gene function.

27 eriments are all employed to study mammalian gene function.

28 fic mutations that knock-out or alter target gene function.

29 ecular mechanisms for GWAS signals affecting gene function.

30 ns, are fundamental tools for elucidation of gene function.

31 few pathologies result from complete loss of gene function.

32 me needed and cost consumed for establishing gene function.

33 ms has been accompanied by divergence in MS2 gene function.

34 uppresses the effects of rare disruptions to gene function.

35 pression experiments, and prior knowledge of gene function.

36 is a powerful approach for the discovery of gene function.

37 /Cas9 system is a powerful tool for studying gene function.

38 nteraction of the pregnancy environment with gene function.

39 mportant for generating hypotheses regarding gene function.

40 dicative of a reactivation of abnormal clock gene function.

41 be modulated, provide valuable insights into gene function.

42 hniques for discovering phenotype-associated gene function.

43 he importance of posterior prevalence in Hox gene function.

44 f-function reagents for the determination of gene function.

45 cies, thus allowing genome-wide inference of gene function.

46 t DNA, RNA or protein to reduce or to ablate gene function.

47 s the application of the technology to study gene function.

48 accuracy on predicting all three domains of gene function.

49 ontext of expression data and help elucidate gene function.

50 es of selection against heterozygous loss of gene function.

51 cs for spatial and/or temporal regulation of gene function.

52 h 'human knockouts' can provide insight into gene function.

53 ics of archaea that holds promise to unravel gene function.

54 as well as in studying gene expressions and gene functions.

55 omic studies or rapidly assessing individual gene functions.

56 omosomes is quintessential for understanding gene functions.

57 the type of dataset impacts inferences about gene functions.

58 y the cell types where the associated causal gene functions.

59 on maps were used to predict tissue-specific gene functions.

60 developed to accelerate the investigation of gene functions.

61 r the mouse genetics community to understand gene functions.

62 oups of co-regulated genes, to infer unknown gene functions.

63 effectively utilizes the similarity between gene functions.

64 genes will be valuable for the study of VACV gene functions.

65 frequently used vocabulary for representing gene functions.

66 for data mining and deeper understanding of gene functions.

67 Transgenic gerbera plants were used to infer gene functions.

68 this result is explained if transposons near genes function.

69 dings suggest that the common themes of SoxB gene function across phylogeny lie in specifying develop

70 combining metabolomics, transcriptomics, and gene function analyses to characterize gene-to-terpene a

71 However, a tool for rapid transient gene function analysis in maize that may be utilized in

72 n mice have provided tremendous insight into gene function and congenital disorders.

73 SNPs, we highlight mechanistic links to AMH gene function and demonstrate highly significant sex int

74 sposon system should facilitate the study of gene function and directed differentiation in human stem

75 al disorders and provided insights into both gene function and disease biology.

76 However, the mechanistic link between gene function and disease is incompletely understood.

77 repeats is implicated in the modification of gene function and disease phenotype.

78 ernative splicing (AS) can critically affect gene function and disease, yet mapping splicing variatio

79 rative bioinformatics tools for the study of gene function and evolution in legumes.

80 results provide novel insights into paired R gene function and evolution.

81 ering plants have resulted in differences in gene function and expression patterns, contributing to d

82 a valuable tool for both genetic analysis of gene function and for synthetic biology applications.

83 ts providing insight into gene essentiality, gene function and genetic interactions.

84 pretation for obtaining insights into cancer gene function and genetic tumor evolution.

85 rain development provides vital insight into gene function and identifies critical sensitive periods

86 eir tissues and genes of interest or examine gene function and interaction predictions across multipl

87 le strategy for globally interrogating miRNA gene function and miRNA-based therapeutic intervention.

88 e of the importance of in vivo assessment of gene function and modeling of human diseases, this techn

89 not only to the study of human hematopoietic gene function and networks, but also to perform sophisti

90 tools available in C. hirsuta to investigate gene function and phenotypic diversification.

91 tat.ubc.ca/GNAT, which allows exploration of gene function and regulation in a tissue-specific manner

92 These patterns of gene function and regulation of CRTC1 are distinct from

93 garded as important readouts of tissue-level gene function and regulatory processes, they have rarely

94 alleles that may prove useful in studies of gene function and the dissection of quantitative genetic

95 ng remaining challenges, such as discovering gene function and the evolution of GRNs.

96 xpression analysis is widely used to predict gene function and to identify functionally related gene

97 remitting patients differ from controls with gene function and transcription factor analyses potentia

98 ation with curated phenotypes, cell-specific gene functions and a multiscale model.

99 ve as a powerful tool for dissecting in vivo gene functions and biological processes in a temporal ma

100 gain-of-function approach for interrogating gene functions and for manipulating biological traits.

101 ion of the two offers the opportunity to map gene functions and gene networks in vivo at single-cell

102 m is a useful tool for the study of specific gene functions and may allow the identification of antig

103 ral evolution and sequence diversity on KSHV gene functions and pathogenesis.

104 on of fungal proteome and revealed important gene functions and proteome dynamics.

105 is has provided new and global insights into gene functions and roles.

106 , aiming to bridge the gap between genomics, gene functions and traits.

107 f-function studies are key for investigating gene function, and CRISPR technology has made genome edi

108 alities seen in aged flies lacking iPLA2-VIA gene function, and restore mitochondrial membrane potent

109 eripheral circadian rhythms, circadian clock gene function, and sleep in maintaining brain homeostasi

110 y spikes in inflammation-favoring organisms, gene functions, and serum and stool metabolites.

111 titative trait loci, have helped to identify genes, functions, and mechanisms of prime importance for

112 enes, with individual peptides from the same gene functioning antagonistically to modulate nociceptio

113 e, uncovering genetic defects and annotating gene function are challenging.

114 techniques enabling conditional analysis of gene function are limited.

115 ecipitation (ChIP-seq) revealed BAZ1B target gene functions are enriched for neurogenesis, neuron dif

116 Although gene functions are relevant to tissue context, most exis

117 New gene functions arise within existing gene families as a

118 by allowing spatio-temporal manipulation of gene function as well as cell and neural circuit functio

119 research that can provide new insights into gene function as well as new targets for drug developmen

120 we show that BEX1 is a heart failure-induced gene functioning as an mRNA-associated protein that enha

121 inding protein dyskerin, encoded by the DKC1 gene, functions as a core component of the telomerase ho

122 We propose that the Aux/IAA genes function as hubs that integrate genetic and enviro

123 Combining high-throughput gene function assays with mechanistic models of the impa

124 that Y-linked genes have evolved convergent gene functions associated with testis expression.

125 st, especially in the context of discovering gene function at scale.

126 Thus, the library of gene functions available to the community, rather than t

127 rline the potential to identify new genes or gene functions based on observations in non-model plants

128 ul4 suggests the partial conservation of BOP gene function between dicots and monocots, while phyloge

129 ant mice, arguing for strong conservation of gene function between these two species.

130 erfering RNA (siRNA) is widely used to study gene function, but Cryptosporidium species lack the enzy

131 ination, are important tools in the study of gene function, but have potential side effects due to da

132 nterference (RNAi) is widely used to analyse gene function, but recently, it has shown potential to c

133 s have been widely adopted to analyze coding-gene functions, but high-throughput screening of non-cod

134 tion codons (PTCs) in an mRNA ORF inactivate gene function by causing production of a truncated prote

135 eating a genome- and phenome-wide catalog of gene function by characterizing new knockout-mouse strai

136 Restoration of colibactin gene function by complementation reestablished the fully

137 titutes state-of-the-art technology to study gene function by facilitating inducible expression in a

138 sition, and its impact on diversification of gene function by genome shuffling.

139 CRISPR is widely used to disrupt gene function by inducing small insertions and deletions

140 ombination of molecular screens and tests of gene function by morpholino-mediated knockdown, we ident

141 se models in laboratory animals and to study gene functions by silencing, activating, or modifying th

142 pression caused by the perturbation of clock gene function can have large effects on the growth of ad

143 n in a cichlid fish shows that dissection of gene function can reveal basic control mechanisms for be

144 t size for a habitat suggested four putative gene function categories associated with a habitat in bo

145 The emergence of four gene function categories combined with a lack of paralle

146 Manipulating gene function cell type-specifically is a common experim

147 ion will provide powerful tools for studying gene function, developmental pathways, and disease mecha

148 acute manipulations more likely reveal basic gene functions, developmental plasticity can be a major

149 ge differentiation phenotypes, cell-specific gene functions, differentiation landscapes and fate choi

150 As a tool for gene function discovery and improvement of this importan

151 Loss of XBAT35 gene function disrupts the plant's ability to defend aga

152 ations that can further our understanding of gene function during postembryonic development and in di

153 transform our ability to rapidly interrogate gene function during the development of this recalcitran

154 Gene function enrichment identified 158 gene ontology cl

155 m genes in parasitoid wasps to study how new gene functions evolve.

156 Mice with altered nAChR gene function exhibit PFC-dependent behavioral deficits,

157 Inducible loss of gene function experiments are necessary to uncover mecha

158 d the choice of dataset, annotation quality, gene function, expression similarity measure, and cluste

159 e served as the foundation for understanding gene function for more than 100 years.

160 coli bacteria that the RtcR activated rtcAB genes function for ribosome homeostasis involving rRNA s

161 coveries also contribute to our knowledge of gene function, gene regulation, development, and biologi

162 t can greatly enhance our ability to predict gene function genome-wide.

163 century VARVs, indicating that such loss of gene function had occurred before ca. 1650.

164 egime in stem cell niches that centre on WOX gene function has been elusive, and molecular links unde

165 resource permits rapid unbiased screens and gene/function identification and will enable exploration

166 ession analysis has been employed to predict gene function, identify functional modules, and determin

167 o enable the discovery of: (i) new leads for gene function, (ii) non-coding RNAs; (iii) genes, pathwa

168 lation is critically important to understand gene function in a particular cellular context.

169 l differentiation and the ability to dissect gene function in a temporal manner.

170 Here we show that the Toll gene function in axis elongation is, in fact, widely con

171 have underpinned comprehensive assessment of gene function in bacteria and eukaryotes.

172 sion or deletion is critical for elucidating gene function in biological systems.

173 structure and epigenetic mechanisms regulate gene function in both development and disease.

174 A better understanding of gene function in C4 plants is now needed to inform more

175 scalable strategy to study tumor suppressor gene function in cancer.

176 ene-specific activation and investigation of gene function in Chlamydomonas.

177 reating a platform for systematic screens of gene function in developing and adult flies with unprece

178 ources, which have been key to understanding gene function in diploid model organisms, are missing in

179 asic loop helix (bHLH) proteins by comparing gene function in early divergent and derived land plant

180 l substantially transform the way we examine gene function in human cells.

181 ity of rare disease genomic studies to parse gene function in human developmental pathways.

182 (HLOF) variants provide a valuable window on gene function in humans, as well as an inventory of the

183 th human phenotypes can provide insight into gene function in humans.

184 stem provides an effective method to disrupt gene function in mammalian cells, and has been applied t

185 Genetic screens help infer gene function in mammalian cells, but it has remained di

186 utility for understanding and interrogating gene function in mammalian cells.

187 application for high-throughput analysis of gene function in mice.

188 Overall, we show that large-scale studies of gene function in model organisms provide a powerful appr

189 ble base pairs in primate genomes and affect gene function in multiple ways.

190 HAIR DEFECITVE SIX-LIKE2 (PpRSL1 and PpRSL2) gene function in P. patens.

191 iding a fast and easy platform for assessing gene function in planta.

192 already proven their utility for analysis of gene function in plants, leading to improved breeding st

193 rently lack the means to identify and modify gene function in specific subsets of midbrain dopaminerg

194 d by an approach that explores P. aeruginosa gene function in systems-level models.

195 diting can enable reverse genetic studies of gene function in the brain.

196 ereby allowing high-resolution dissection of gene function in the context of bacterial operons.

197 iting is a powerful method for investigating gene function in the context of human development.

198 and the wide range of mechanistic effects on gene function in the context of signalling networks.

199 ificant; it extends our understanding of Dlx gene function in the developing forebrain beyond the reg

200 Probing gene function in the mammalian brain can be greatly assi

201 the potential for rapid characterisation of gene function in these species.

202 rculosis pathogenesis, analysis of essential gene function in this slow-growing pathogen remains diff

203 This approach makes possible the study of gene function in vivo in unperturbed cells of hematopoie

204 notypes become the standard metric to define gene function in zebrafish, after which Morpholinos that

205 show that despite extensive study of B class gene functions in diverse flowering plants, novel insigh

206 s are being harnessed to probe combinatorial gene functions in functional genomics studies and have t

207 The genome-wide identification of gene functions in malaria parasites is hampered by a lac

208 irst glimpse into the diversity of predicted gene functions in Ostreococcus viruses originating from

209 ruction of genetic circuits with predictable gene functions in plants.

210 d here permitted unprecedented assessment of gene functions in regulating crucial dynamic aspects of

211 is Primer, I summarise how this multifaceted gene functions in various mammalian tissues and organs,

212 to link primary DNA sequence information to gene functions in vertebrate models.

213 rk for systematic investigation of essential gene functions in vivo broadly applicable to diverse mic

214 Cas9 as a robust tool to study novel cardiac gene functions in vivo.

215 To study how genes function in a cellular and physiological process,

216 gly, most of these differentially methylated genes function in cell adhesion and communication pathwa

217 rray analyses revealed that JMJD1A-dependent genes function in cellular growth, proliferation and sur

218 owever, about how, or even whether, co-opted genes function in eyespot development.

219 This suggests that Epg5 and other Atg genes function in macrophages to limit innate immune inf

220 phenotypic variation that can elucidate how genes function in networks to collectively shape ocular

221 othesized that Dlx1, Dlx2 and Brn3b homeobox genes function in parallel intrinsic pathways to determi

222 The SERK1/2 genes function in the same genetic pathway as EMS1 in an

223 , there is little understanding of how these genes function in vivo and what the clinical implication

224 amk2-specific negative interactors included genes functioning in chromatin silencing and DNA damage

225 The transcript levels of most genes functioning in energy metabolism pathways are cohe

226 including strong representation of conserved genes functioning in signalling.

227 gsk3-specific negative interactors included genes functioning in translation and ribosomes.

228 lecture in which he outlined key ideas about gene function, in particular what he called the central

229 ion stability across environments and shared gene function increase the likelihood of observing an in

230 ative splicing events (ASE) that could alter gene function independent of mutations.

231 Network-based gene function inference methods have proliferated in rec

232 Phenotypic and gene function information has been obtained by manual cu

233 A-guided DNA endonuclease Cas9 determine how gene function is altered.

234 A powerful method to study gene function is expression or overexpression in an indu

235 anisms are difficult since information about gene function is lacking.

236 Gene function is mostly characterized through overexpres

237 rstanding the genetic and molecular bases of gene function is of increasing importance to harness the

238 GWAS schizophrenia variants whose associated gene function is related to synaptic transmission, and (

239 but can be used as a standard approach when gene function is studied.

240 lend support to the notion that loss of ndh gene function is the first step of plastome degradation

241 The classic model for the evolution of novel gene function is through gene duplication followed by ev

242 The most widely used approach for defining gene function is to reduce or completely disrupt its nor

243 oth prokaryotes and eukaryotes, insight into gene function is typically obtained by in silico homolog

244 Similarity of GO terms and gene functions is quantified with six different scores i

245 rganisms gain greater fitness increases from gene/function loss events than is commonly expected.

246 ncing and new technologies for investigating gene function, many new plant models are being proposed

247 results highlight that important promiscuous gene function may be missed when annotation relies solel

248 should facilitate research aimed at defining gene functions, modelling of cancers and other diseases

249 Finding the minimal set of gene functions needed to sustain life is of both fundame

250 ns has led to ground-breaking discoveries in gene-function, neuronal circuits, and physiological resp

251 decisive importance to our understanding of gene function, no Nobel Prize was awarded for its discov

252 stablish that human collybistin, the loss of gene function of which causes severe encephalopathy, is

253 es to annotated genes to confidently predict gene function or homology.

254 each a better understanding of either single gene function or metabolic pathway structure and regulat

255 nown essential genes in E. coli, and has 78% gene function overlap with minimal genomes (Buchnera aph

256 understudied mechanism of evolution for new gene functions, particularly under conditions of rapid e

257 gical reference data related to mouse genes, gene functions, phenotypes and disease models with a str

258 etwork (GCN) can be constructed and used for gene function prediction, candidate gene selection, and

259 onnection between xenolog classification and gene function prediction.

260 lgorithm development has little to offer for gene function prediction.

261 and human osteoblast expression studies; (2) gene-function prediction; (3) skeletal phenotyping of 12

262 ated reprogramming indicating that the PpCSP genes function redundantly in cellular reprogramming.

263 y in maturing organisms without compromising gene functions regulated by developmental signals.

264 le is precisely regulated for the purpose of gene function regulation.

265 Systematic interrogation of gene function requires the ability to perturb gene expre

266 Loss of MtMATE67 gene function resulted in accumulation of Fe in the apop

267 This unbiased morphologic map of gene function revealed TRAF2/c-REL negative regulation o

268 down but profoundly affected by depletion of gene function, revealing intimate connections between ce

269 ntal data with the latest genome annotation, gene function, RNA sequence and structure.

270 he relationship becomes negative for a given gene function (rs approximately -0.13).

271 Importantly, mild knockdown of essential gene functions significantly reduced stationary-phase su

272 ms in many maize lines, making it useful for gene function studies in critically important maize cult

273 ctor provides a tool for rapid and efficient gene function studies in maize.

274 ene silencing (VIGS) is used extensively for gene function studies in plants.

275 To adopt the alphoid(tetO)-HAC for routine gene function studies, we constructed a new TAR-BRV- tTA

276 plants-and are strongly biased in predicted gene functions, suggesting that expression products of h

277 efficient approach to investigate essential gene function that may be particularly useful in charact

278 enabled the definition of sets of genes and gene functions that were acquired or lost in specific li

279 itors requires CREB-CBP interaction and Nr4a gene function, these data support the notion that the ba

280 with spatiotemporal expression patterns and gene function, this capability has the potential to impr

281 pression has been widely used to hypothesize gene function through guilt-by association.

282 l links and help researchers to choose which gene functions to investigate in a biological event.

283 , an integrative tool that employs predicted gene functions to systematically prioritize the most lik

284 he mechanisms by which interferon-stimulated genes function to inhibit viral replication.

285 d by Pare et al., who showed that three Toll genes function together to drive cell intercalation duri

286 Essential gene functions underpin the core reactions required for

287 ated, cross-species approaches to uncovering gene function using functional genomics and other approa

288 l microscopy is a powerful tool for studying gene functions using strain libraries, but it suffers fr

289 ts) effort aimed at accelerating the rate of gene function validation.

290 be used to further the understanding of ASFV gene function, virus attenuation, and protection against

291 Gene function was characterized by down-regulation and o

292 Gene function was investigated and pathway analysis was

293 To functionally test gene function, we develop an efficient (up to 92.5%) CRI

294 ing of bptf in zebrafish to induce a loss of gene function, we observed a significant reduction in he

295 One strategy for uncovering gene function when single-mutant lines do not produce an

296 genes or cause the loss of tumor suppressing gene function which can lead to tumorigenesis by downreg

297 rkable example of emergence and evolution of gene function, which we have been able to trace thanks t

298 CRISPR-Cas9 system enables global screens of gene function with high sensitivity and specificity, but

299 g toolbox are helping researchers understand gene function with unprecedented precision and sensitivi

300 imited by a lack of technologies that ablate gene function within specific mononuclear phagocyte sub-