ライフサイエンスコーパス: gene inactivation

1 o one oncogenic mutation or tumor suppressor gene inactivation.

2 ting a classic mechanism of tumor suppressor gene inactivation.

3 cause of Dravet syndrome through functional gene inactivation.

4 ion (Msh2(LoxP)), permitting tissue-specific gene inactivation.

5 an R-band cannot be accounted for by direct gene inactivation.

6 r the Sir4 pathway of telomere tethering and gene inactivation.

7 pearing to be important mechanisms of Cables gene inactivation.

8 t phenotypic consequences than one caused by gene inactivation.

9 oncogene activation and p53 tumor suppressor gene inactivation.

10 entric DNA is related to heterochromatin and gene inactivation.

11 er methylation is the commonest mechanism of gene inactivation.

12 mmary gland development by using conditional gene inactivation.

13 ic consequences of conventional global Clcn3 gene inactivation.

14 rs are characterized by VHL tumor suppressor gene inactivation.

15 with deregulated c-myc for evidence of Ink4 gene inactivation.

16 osphoribosyl transferase locus, resulting in gene inactivation.

17 anges and allelic loss, for tumor suppressor gene inactivation.

18 g for variegated phenotypes, that is, mosaic gene inactivation.

19 was also rescued by conditional beta-catenin gene inactivation.

20 thylation equivalent phenomenon resulting in gene inactivation.

21 for cell-mediated gene transfer and targeted gene inactivation.

22 romatin and has been implicated in heritable gene inactivation.

23 loci, similar to the mutator effect of MLH1 gene inactivation.

24 expanded to include epigenetic mechanisms of gene inactivation.

25 , consistent with very strong intolerance to gene inactivation.

26 ing SP-A (SP-A-/-) were produced by targeted gene inactivation.

27 is required to block methylation-associated gene inactivation.

28 rational design of ribozymes directed toward gene inactivation.

29 n as a direct mechanism for tumor suppressor gene inactivation.

30 ic acid, which is a selective agent for URA5 gene inactivation.

31 parable with the effects observed with PDE12 gene inactivation.

32 irmed in human cells by CRISPR/Cas9-mediated gene inactivation.

33 on activator-like effector nuclease-mediated gene inactivation.

34 ral control of fluorescent cell-labeling and gene inactivation.

35 ologous end joining (NHEJ), often leading to gene inactivation.

36 n GRB2 expression was reduced by shRNA or by gene inactivation.

37 sequence is deleted, resulting in F8(F-->KO) gene inactivation.

38 phorylation, the epigenetic event leading to gene inactivation.

39 e genomic aberrations that can contribute to gene inactivation.

40 ather than a discrete, local coordination of gene inactivation.

41 s been an accepted means of tumor suppressor gene inactivation, activation of otherwise normally repr

42 y tobacco smoke occurs in a series of target gene inactivations/activations in defined modules of a g

43 The pattern of species-specific gene inactivations affecting transcriptional regulators

44 Systematic gene inactivation allowed determination of the precise b

45 xperimentally generated in mice by alpha-TTP gene inactivation (alpha-TTP-KO).

46 studies were designed to assess whether TSC gene inactivation alters excitability.

47 ST) library-based antisense method of random gene inactivation and a phenotypic screen for limitation

48 namics during preimplantation development of gene inactivation and acquisition of repressive histone

49 However, gene inactivation and analysis of the accumulated produc

50 hodobacter sphaeroides, were investigated by gene inactivation and biochemical studies.

51 lvement in TTM biosynthesis was confirmed by gene inactivation and complementation experiments.

52 Genome degradation, marked by gene inactivation and deletion, is a key feature of host

53 ct the functional relationship between Cav-1 gene inactivation and ERalpha expression, we isolated pr

54 ncovers novel mechanisms of tumor-suppressor gene inactivation and highlights a new approach to cance

55 sporadic clear cell RCC samples without VHL gene inactivation and in 13 individuals with familial no

56 By in vivo gene inactivation and in vitro biochemical characterizat

57 n prompted us to examine the effect of Kv1.3 gene inactivation and inhibition on peripheral glucose h

58 l mechanism of self-encoded tumor suppressor gene inactivation and link a relatively common single nu

59 Gene inactivation and loss are particularly apparent in

60 usses the principle underlying M1GS-mediated gene inactivation and methodologies involved in effectiv

61 that an epigenetic mechanism underlies hMLH1 gene inactivation and MMR deficiency.

62 mA gene in TTM biosynthesis was confirmed by gene inactivation and mutation complementation experimen

63 results suggest that rapid and irreversible gene inactivation and pathway degeneration are associate

64 ions are due to the combinational results of gene inactivation and polar effects caused by intron ins

65 Targeted gene inactivation and protein interaction studies demons

66 Following gene inactivation and replacement in human cells, we dem

67 Gene inactivation and reporter expression is achieved th

68 Gene inactivation and RNAi-mediated knockdown of AtCPT7

69 o function of mouse tankyrase 2 by germ line gene inactivation and show that inactivation of tankyras

70 r proteins have been elucidated by selective gene inactivation and subsequent phenotypic analysis.

71 road utility of the approach for conditional gene inactivation and suggests that this tool could be u

72 Here we demonstrate by both gene inactivation and target protein blockade that a sin

73 ture regarding VEGF, von Hippel-Lindau (VHL) gene inactivation and VEGF overexpression in RCC was per

74 ssion and Cre-recombinase-loxP site-mediated gene inactivation, and (2) simplifies schemes of animal

75 es in concert with gene sequencing, cloning, gene inactivation, and animal testing offers an efficien

76 by microsomal triglyceride transfer protein gene inactivation, and mice were treated with anti-miR33

77 t sequence information permits a broad-based gene inactivation approach in C. elegans, in which chemi

78 and therefore complementing the conventional gene inactivation approach to finding mutators.

79 ouse mes/met development using a conditional gene inactivation approach.

80 ss potential limitations in the Cre-mediated gene inactivation approach.

81 demonstration of epigenetic tumor-suppressor gene inactivation associated with promoter methylation,

82 ripheral nerve dysfunction and whether COX-2 gene inactivation attenuates nerve fiber loss in long-te

83 icient and reliable, and permits conditional gene inactivation based on both spatial and temporal cue

84 To facilitate gene inactivation by induction of STOP codons (iSTOP), w

85 n antiestrogen-resistant cells compared with gene inactivation by promoter hypermethylation, revealin

86 Gene inactivation by RNA interference shows that set-1 i

87 es and phase-variable and non-phase-variable gene inactivation by the deletion or insertion of bases.

88 Gene inactivation by transposon insertion or allelic exc

89 Although the role of complete gene inactivation by two loss-of-function mutations inhe

90 e perturbations and suggest that recovery by gene inactivation can lead to rapid divergence in the pa

91 tibody binding demonstrated that as few as 3 gene inactivations can reduce the levels human antibody

92 Gene inactivation causes mice (Kv1.3-/-) exposed to a hi

93 ereas loss at later stages combined with Nf2 gene inactivation causes shwannomas.

94 In mice with Col9a1 gene inactivation (Col9a1(-/-)), osteoarthritis (OA) and

95 olvement in FDM A biosynthesis was proven by gene inactivation, complementation, and heterologous exp

96 Irrespective of the timing of Pkd1 gene inactivation, cystic kidneys showed enhanced uptake

97 in each locus, strains were constructed with gene inactivation, deletion, and/or reporter gene fusion

98 genetics of chromatin remodeling reveal that gene inactivation depends on the recruitment of enzymes

99 n, per se, does not result in a high rate of gene inactivation, despite greatly accelerated retrotran

100 -allelic somatic (glial progenitor cell) Nf1 gene inactivation develop brain tumors that do not fully

101 mice further demonstrated that B13R or B22R gene inactivation diminishes VV virulence, as measured b

102 isingly, the Nestin-Cre mice used to mediate gene inactivation displayed a phenotype.

103 These gene inactivations disrupt the increased expression of t

104 Some of these gene inactivations dramatically shorten daf-2 mutant lif

105 Many of the gene inactivations enhance exogenous RNAi.

106 tisense EST libraries for global chromosomal gene inactivation, establish the practicality of loss-of

107 ged from a common ancestor after the massive gene inactivation event described previously for M. lepr

108 here will be a crucial tool for conditional gene inactivation exclusively in the anterior heart fiel

109 lls that, as a consequence of shRNA-mediated gene inactivation, exhibited defective agonist-induced d

110 dioxane unit through (13)C labeling studies, gene inactivation experiments and enzymatic synthesis.

111 . arenicola circular genome and PCR-targeted gene inactivation experiments identified the 47 kb cyclo

112 Gene inactivation experiments in B. subtilis indicate th

113 Gene inactivation experiments in mice have identified fa

114 Although the gene inactivation experiments indicate that haploinsuffi

115 cyclomarin A was further illuminated through gene inactivation experiments, which suggest that the tr

116 further supported by the results of in vivo gene inactivation experiments.

117 s, and has been further supported by in vivo gene inactivation experiments.

118 s provides a scalable systematic approach to gene inactivation for any organism that can be handled i

119 eritable IR genes confer potent and specific gene inactivation for each of these applications.

120 nt test strains were used to filter progeric gene inactivations for specific acceleration of aging.

121 Mice with targeted Piga gene inactivation genetically mimic the human disease an

122 Targeted gene inactivation has demonstrated a crucial role for Ba

123 tudies in mice with liver-specific or global gene inactivation have shown that hypoxia-inducible fact

124 d 2, then elucidated the pathway with target gene inactivation, heterologous reconstitution, and bioc

125 Because of this gene inactivation, humans, apes, and Old World monkeys l

126 mmary, GATA1-Cre causes high-efficiency Piga gene inactivation in a GATA-1-specific pattern.

127 oter CpG islands is a frequent mechanism for gene inactivation in a variety of human cancers, includi

128 s an important mechanism of tumor suppressor gene inactivation in a variety of human cancers.

129 Zinc-finger nucleases (ZFNs) allow targeted gene inactivation in a wide range of model organisms.

130 the impact of glucose transporter 2 (Glut2) gene inactivation in adult mouse liver (LG2KO mice).

131 We show further that Adfp gene inactivation in apolipoprotein E-deficient (ApoE(-/

132 th mesenchyme, through neural crest-specific gene inactivation in Bmp4(f/f);Wnt1Cre mice, caused mand

133 hromatin constitutes a frequent mechanism of gene inactivation in cancer.

134 Partial fibrillin 1 gene inactivation in cardiomyocytes was sufficient to pr

135 ene constitutes an alternative mechanism for gene inactivation in colon and other tumors of the gastr

136 In this study we identified as a target for gene inactivation in colon cancer the gene for helicase-

137 findings support the pathogenic role of MMR gene inactivation in colorectal tumorigenesis and provid

138 However, conditional gene inactivation in diploid cells is still difficult to

139 Jaiswal et al. (2015) to perform conditional gene inactivation in Drosophila.

140 ly demonstrated that astrocyte-specific Tsc1 gene inactivation in mice (Tsc1 cKO mice) results in pro

141 In contrast, Sorl1 gene inactivation in mice accelerated breakdown of triac

142 Hcrt gene inactivation in mice leads to behavioral state inst

143 Plekhg5 gene inactivation in mice results in a late-onset motone

144 We show that PDE4D gene inactivation in mice results in a progressive cardi

145 Using cell type-specific gene inactivation in mice, we show that CCM3 has both ce

146 s been used for conditional and conventional gene inactivation in mice.

147 Acute Krit1 gene inactivation in mouse brain microvascular endotheli

148 hylation has been linked to tumor suppressor gene inactivation in neoplasia and may serve as a useful

149 ic mice, to enable tamoxifen-inducible Hif1a gene inactivation in nestin-expressing NSCs within the a

150 ird, in contrast to the GFAP-Cre strain, Nf1 gene inactivation in NG2+ cells is not sufficient for op

151 used a conditional knock-out approach to BiP gene inactivation in oligodendrocytes during development

152 When BiP gene inactivation in oligodendrocytes was initiated in a

153 lt in a reduction of three major pathways of gene inactivation in our model system.

154 1 promoter may be the principal mechanism of gene inactivation in sporadic CRC characterized by wides

155 or biochemical analysis; and (iii) effective gene inactivation in the nervous system.

156 To enable in vivo CRISPR/Cas9-mediated gene inactivation in the pancreas, we generated a Cre-re

157 The role of DPC4 tumor suppressor gene inactivation in this progression has not been defin

158 a mechanistic account of the role of RASSF1A gene inactivation in tumor initiation is lacking.

159 c deletion are two predominant mechanisms of gene inactivation in tumorigenesis, but the extent to wh

160 w alternative mechanism for tumor suppressor gene inactivation in tumorigenesis.

161 e and easily adaptable method of conditional gene inactivation in vertebrates.

162 that this is a viable platform for heritable gene inactivation in vertebrates.

163 activation in cultured ECs, and its targeted gene inactivation in vivo alters Notch-dependent vascula

164 -mediated knockdown in vitro and conditional gene inactivation in vivo to study the role of the G(12/

165 Loss of YFP(+) NSCs following Hif1a gene inactivation in vivo was likely an indirect consequ

166 ovides a resource to allow targeted germline gene inactivation in zebrafish and highlights the benefi

167 ell-based gene transfer approach to targeted gene inactivation in zebrafish.

168 ISPR-based vector system for tissue-specific gene inactivation in zebrafish.

169 mbly-based approach for ZFN construction and gene inactivation in zebrafish.

170 Analysis of the fat-reducing gene inactivations in insulin, serotonin and tubby signa

171 osynthetic pathway, using systematic in vivo gene inactivation, in vitro biochemical assays, and tota

172 erations, including disparate roles for MEN1 gene inactivation, indicate that markedly different mole

173 In addition, Cav-1 gene inactivation induces the accumulation of a cell pop

174 Caveolin-1 (Cav-1) gene inactivation interferes with caveolae formation and

175 Tumor suppressor gene inactivation is a crucial event in oncogenesis.

176 7(Kip1) is cell-autonomous because biallelic gene inactivation is absent from tumors arising in p27(K

177 Specifically, we demonstrated that gene inactivation is an important mechanism for altering

178 re, we found that robustness to heterozygous gene inactivation is not due to dosage compensation.

179 Von Hippel-Lindau gene inactivation is observed in most clear cell renal c

180 ation or deletion (genetic) tumor suppressor gene inactivation is that epigenetic inactivation can be

181 Biallelic RB1 gene inactivation is the initiating genetic lesion in re

182 Similar to the effects of Cdk5 gene inactivation, knockdown of nestin in agrin-deficien

183 Out of 50 C. elegans gene inactivations known to mediate mitochondrial defens

184 TSC gene inactivation leads to hyperactivation of the mammal

185 In principal cells in the kidney, TWIK1 gene inactivation leads to the loss of a nonselective ca

186 Constitutive SOS expression by lexA gene inactivation (lexA71::Tn5) and recA gene mutation (

187 Transposon (Tn) gene-inactivation libraries were generated in three C. j

188 mitochondrial surveillance defects of other gene inactivations, mapping these gene activities upstre

189 led quantitative analysis of the three major gene inactivation mechanisms for a model gene at two dif

190 Gene inactivation mechanisms include events resulting in

191 To study the interaction of these gene-inactivation mechanisms in primary brain tumors, we

192 e show a new molecular mechanism of ER-alpha gene inactivation mediated by pRb2/p130 in ER-negative b

193 tion, we describe the development of a novel gene inactivation methodology to target B. burgdorferi f

194 Here we show using cell-specific gene inactivation models that gamma-carboxylation of OCN

195 GIM(3)E (Gene Inactivation Moderated by Metabolism, Metabolomics

196 e Golgi by N-acetylglucosaminyltransferase I gene inactivation nor PNGase F deglycosylation of fully

197 s of mammalian erythropoiesis include global gene inactivation, nuclear condensation, and enucleation

198 order to understand the specific patterns of gene inactivation observed in different subtypes of lung

199 ent, we recently generated mice in which Nf1 gene inactivation occurs in neuroglial progenitor cells

200 von Hippel-Lindau (VHL) gene inactivation occurs in von Hippel-Lindau (VHL) dise

201 Targeted gene inactivation of Bbcal1 did not appear to affect spo

202 ciple studies and tested the hypothesis that gene inactivation of Ccr2 or Ccr5 will ameliorate experi

203 Gene inactivation of components of the cytosolic chapero

204 Likewise, gene inactivation of each of the 2 receptors in neutroph

205 om mutant strains constructed by insertional gene inactivation of either of these two genes.

206 Pharmacological inhibition or gene inactivation of EP1 receptors ameliorates brain inj

207 ion and can promote HCC cell invasiveness by gene inactivation of multiple invasion-suppressor miRNAs

208 Gene inactivation of nhx-2 by RNAi led to a loss of fat

209 Gene inactivation of opt-2 led to a phenotype resembling

210 hA two- to threefold, as was demonstrated by gene inactivation of phhB in P. aeruginosa and by compar

211 , we describe the results of tissue-specific gene inactivation of plexinD1 in Tie2 expressing precurs

212 Gene inactivation of pRB through chromosomal mutations i

213 OR transport is inhibited by conditional gene inactivation of the Hedgehog signal mediator Smooth

214 However, targeted gene inactivations of Lef1, Tcf1, or Tcf4 in the mouse d

215 In cells with an intact rb gene, inactivation of pRb by HPV E7 abrogates the growth

216 esis is unique among the known heterochronic genes: inactivation of lin-42 causes the elongating gona

217 e identify a class of highly connected 'hub' genes: inactivation of these genes can enhance the pheno

218 NF2 gene inactivation on chromosome 22 has been shown as an

219 iranda, in order to test competing models of gene inactivation on its newly evolving Y chromosome (th

220 We examined the effects of autophagy gene inactivation on Salmonella enterica Serovar Typhimu

221 for humans, independent mechanisms involving gene inactivation or altered expression of virulence det

222 me cases, the frameshift mutation results in gene inactivation or decay.

223 We hypothesize that metastasis suppressor gene inactivation or down-regulation plays a role in ova

224 ve response was not initiated by in vivo Vhl gene inactivation or pharmacological inhibition of proly

225 ular processes by small molecule inhibitors, gene inactivation, or targeted knockdown strategies comb

226 s that influence the relative utilization of gene inactivation pathways are poorly understood.

227 f DNA methylation to these various competing gene inactivation pathways.

228 to determine whether these two mechanisms of gene inactivation play a complimentary role in medullobl

229 Our results suggest that PTEN/MMAC1 gene inactivation plays a role in the genesis of some tu

230 Myostatin gene inactivation prevented the severe loss of skeletal

231 Thus, Cav-1 gene inactivation promotes premalignant alterations in m

232 ducing mutated fetuses, the lack of complete gene inactivation resulted in animals with an intact pan

233 ryonic and extra-embryonic tissues, and Cubn gene inactivation results in early embryo lethality most

234 Biallelic NF2 gene inactivation results in the development of central

235 9R, was assigned as a 4-hydroxylase based on gene inactivation results.

236 Multiple time points of gene inactivation reveal that Pax7 is only required up t

237 and was required for rapid repression after gene inactivation, revealing a function for the nuclear

238 gans skr genes were probed by dsRNA-mediated gene inactivation (RNAi).

239 To maximize the chance of target gene inactivation, sgRNAs were curated to target both 5

240 Progression to tumorigenicity upon RASSF1A gene inactivation should therefore require collaborating

241 Cells with heterozygous gene inactivation still contained predominantly diphtham

242 provide a valuable complement to conditional gene inactivation strategies.

243 Here, we use a conditional gene inactivation strategy to show a specific requiremen

244 lict with expectations generated by previous gene inactivation studies and suggest a complex regulati

245 Recent systematic gene inactivation studies have confirmed the integral ro

246 n of H1 subtypes in multicellular organisms, gene inactivation studies have failed to reveal essentia

247 Gene inactivation studies have revealed a critical requi

248 ocyte development, and ectopic expression or gene inactivation studies have revealed several potentia

249 Gene inactivation studies have shown that both stromal c

250 Gene inactivation studies have shown that members of the

251 f congenital heart disease have emerged from gene inactivation studies in mice and from human genetic

252 Targeted gene inactivation studies in mice have shown that VEGF i

253 An estimate of the timing of gene inactivation suggests that pathway degeneration beg

254 neurons, was silenced by the CRISPR-mediated gene inactivation system.

255 zed, mainly due to the paucity of a nonpolar gene inactivation system.

256 through the use of the one-step chromosomal gene inactivation technique to identify SXT genes involv

257 ivations that cause reduced body fat and 112 gene inactivations that cause increased fat storage.

258 We identify 305 gene inactivations that cause reduced body fat and 112 g

259 Furthermore, particular gene inactivations that disrupt RNAi reverse the cell li

260 en of 5,690 Caenorhabditis elegans genes for gene inactivations that increase lifespan.

261 f-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span.

262 , Rankin and colleagues show, using targeted gene inactivation, that induction of Epo expression in m

263 Their potential to expand can lead to gene inactivation, the cause of Friedreich's ataxia dise

264 nfluence on cyst formation by spatiotemporal gene inactivation, the genetic context, the metabolic st

265 riven analysis, heterologous expression, and gene inactivation, the legonmycins were also shown to or

266 Upon gene inactivation, these progeny can dedifferentiate and

267 report that demonstrates selective ERalpha-C gene inactivation through CpG methylation pathway in ute

268 her investigated the mechanisms of ERalpha-C gene inactivation through CpG methylation pathways.

269 We used targeted gene inactivation to define the function of Emp during h

270 Here we use complete and cell-specific gene inactivation to identify the roles of the redundant

271 ble Cre/loxP lineage tracing and conditional gene inactivation to the tibialis anterior muscle regene

272 r receptor, and cyclin D1), tumor suppressor gene inactivation (TP53 and p16), and loss of heterozygo

273 hat lead to gene overexpression (oncogenes), gene inactivation (tumor suppressor genes), or alteratio

274 Combinatorial gene inactivation using an RNAi library is a powerful ap

275 ction, deletion of redundant genes and acute gene inactivation using short hairpin RNA (shRNA).

276 Acute gene inactivation using short hairpin RNA (shRNA, knockd

277 hematopoiesis we therefore chose conditional gene inactivation using the Cre/loxP system.

278 The extent of gene inactivation varies between different cell types an

279 MNR2 gene inactivation was associated with an increase in bot

280 In addition, p16 gene inactivation was determined by DNA sequence analysi

281 te this prediction, a system for conditional gene inactivation was developed.

282 Evidence for tissue-specific gene inactivation was obtained at DNA, RNA, and protein

283 om B31 MI that were infectious for mice, and gene inactivation was successful in one of these clones.

284 clear staining, a likely result of biallelic gene inactivation, was observed in 25% (22 of 85) of pri

285 ons are an alternative means of glioblastoma gene inactivation, we coupled pharmacological manipulati

286 n cell lineage, in addition to biallelic Nf2 gene inactivation, we generated the first mouse model de

287 Using morpholino-based gene inactivation, we have analyzed the function of fgf2

288 tic protein 4 (Bmp4) allele with conditional gene inactivation, we here identify Bmp4 as a signal fro

289 Using tissue-specific gene inactivation, we show that endothelial-specific ina

290 Using conditional gene inactivation, we show that Nr5a2 also plays crucial

291 ion, the phenotypic consequences of temporal gene inactivation were assessed by monitoring animal sur

292 in most cases; however, other mechanisms of gene inactivation were present in some cases.

293 oliferation as demonstrated by Dok1 and Dok2 gene inactivation, which induces a myeloproliferative di

294 ycolylneuraminic acid (Neu5Gc) due to a CMAH gene inactivation, which occurred approximately three mi

295 chimeric URA3 gene, their expansions caused gene inactivation, which was detected on the selective m

296 sters and display species-specific flagellar gene inactivations, which lead to the putative generatio

297 SKO1 was developed by targeted gene inactivation with a replicative plasmid capable of

298 ata point to a novel mechanism of E-cadherin gene inactivation, with CLL cells displaying a higher pr

299 exposure is related to the nature of somatic gene inactivation within crucial pathways, including the

300 e of these mechanisms can pinpoint biallelic gene inactivation without the use of positional cloning.