ライフサイエンスコーパス: gene involved in

1 sociated with SSR resistance, with candidate genes involved in a wide range of processes including ce

2 INTERPRETATIONS: PPP4R3A is a gene involved in AD risk and progression.

3 A compendium combining mammalian genes involved in adaptation to cold environment was des

4 served patterns of transcript abundances for genes involved in ammonium assimilation differed from th

5 ptional program dominated by upregulation of genes involved in anabolic pathways.

6 s, we concluded that epigenetic silencing of genes involved in angiogenesis is a hallmark of the meth

7 simultaneously modulating the expression of genes involved in angiogenic pathways such as VEGF (vasc

8 We examined expression of genes involved in anti-acetylcholine receptor (AChR) res

9 Genes involved in antiparasite defense, on average, incu

10 suppressors by transcriptionally activating genes involved in apoptosis and cell cycle arrest, and t

11 lved in cell survival and down-regulation of genes involved in apoptosis and chromatin structure.

12 gs further expand the existing repertoire of genes involved in ARID, and provide new insights into th

13 iated with the transcriptional activation of genes involved in aromatic amino acid, S-adenosyl methio

14 der and further establish DZIP1L as a second gene involved in ARPKD pathogenesis.

15 ly part of an operon that contains other ars genes involved in arsenic detoxification.

16 ytes, ARID5B knockdown reduced expression of genes involved in atherosclerosis-related inflammatory a

17 is likely reflected in the underlying set of genes involved in auditory function.

18 interpretation of >4,700 cancer genomes and genes involved in autism.

19 , not only in Wnt-pathway genes, but also in genes involved in axon guidance and cytoskeletal remodel

20 Functional prediction showed that genes involved in bacterial mobility, flagellar assembly

21 only active maintaining of the expression of genes involved in beta cell function, but also continual

22 s controlling the expression and activity of genes involved in bile acid, lipid and carbohydrate meta

23 ion by altering the transcription of the vps genes involved in biofilm matrix production.

24 nerated rich genomic resource and identified genes involved in biosynthesis of important molecules, w

25 We analyze the genes involved in both the stages- non metastasis and me

26 igenetic changes may alter the expression of genes involved in BP regulation and explain part of the

27 haracterized by reduced muscle expression of genes involved in branched-chain amino acids (BCAA) meta

28 Expression of genes involved in branching morphogenesis, Gcm1, Syna an

29 Here, we provide a map of all of the genes involved in Ca2+ signaling and link these genes to

30 origenesis by promoting the transcription of genes involved in cancer development.

31 and shared data sets of known and candidate genes involved in cancer.

32 he decreases in messenger RNA expression for genes involved in cardiac energy production and contract

33 t glycolysis regulates the expression of key genes involved in cardiac metabolism and remodeling.

34 altered expression of an array of regulatory genes involved in cardiomyocyte homeostasis and disease

35 DNA methylation in the gene body of DAPK3, a gene involved in cell proliferation, apoptosis, and auto

36 gle ssUVR caused a significant inhibition in genes involved in cell cycle progression, especially G2/

37 shown to modulate expression of clusters of genes involved in cell death and apoptosis pathways in h

38 SOB3) to influence both the transcription of genes involved in cell elongation and hypocotyl growth.

39 onstructed models enabled us to identify key genes involved in cell fate determination and to obtain

40 or that regulates the expression of multiple genes involved in cell growth, viability and tissue-spec

41 l cell adhesion molecules, while mesenchymal genes involved in cell migration and invasion are repres

42 on factors (KLFs) regulate the expression of genes involved in cell proliferation, differentiation an

43 evealed that SRp55 regulates the splicing of genes involved in cell survival and death, insulin secre

44 gene-expression patterns, with activation of genes involved in cell survival and down-regulation of g

45 5 genomic regions, including SNPs in or near genes involved in cellular adhesion, leukocyte migration

46 erated by an alternative pathway to regulate genes involved in cellular growth arrest.

47 We found signatures of positive selection in genes involved in chemoreception, detoxification and dig

48 arly in disease demonstrates upregulation of genes involved in cholangiocyte injury/morphology and do

49 evels, despite the coordinated repression of genes involved in cholesterol and primary bile acid bios

50 genic genes, and transcriptional decrease of genes involved in cholesterol and triglyceride (TAG) met

51 tes and confirmed that SREBP-2 regulates all genes involved in cholesterol biosynthesis, the LDL rece

52 ZmHSF, ZmWRKY, ZmbZIP and PR1) and potential genes involved in chromatin modification.

53 lar transcriptome altering the expression of genes involved in chromatin organization, signaling, adh

54 so observed the upregulation of a network of genes involved in circadian rhythm in both tissues and d

55 sponsive transcription factor that regulates genes involved in circadian rhythm maintenance and metab

56 microbial guilds, each one encompassing one gene involved in CO2 fixation, aside from sulfate reduct

57 eraction networks or how proteins encoded by genes involved in complex brain disorders are distribute

58 esents an important step forward for mapping genes involved in complex diseases.

59 nts a promising approach for identifying new genes involved in complex traits.

60 hydroxylase expression and the regulation of genes involved in cortex development, Eomes and Pax6, in

61 Further, comparative analyses of 17 genes involved in CPT biosynthetic pathway were validate

62 ome profiling indicated that Sox11 activates genes involved in cytoskeletal remodeling and axon growt

63 epatic steatosis due to higher expression of genes involved in de novo fatty acid synthesis, which ar

64 a and its target gene CIDEA as well as other genes involved in de novo lipogenesis.

65 ed for regulatory sequences and depleted for genes involved in defence.

66 However, many genes involved in defense have not yet been exploited fo

67 a more accessible chromatin landscape around genes involved in detoxification pathways.

68 Genes involved in detoxification were significantly incr

69 As a consequence, the actual genes involved in disease are not necessarily the most p

70 We identified several genes involved in disease resistance and pathogen defens

71 Cas9 knockout human cell lines targeting 209 genes involved in diverse cell-cycle processes.

72 e HCFC1/THAP11 complex potentially regulates genes involved in diverse cellular functions including c

73 tive stress biomarkers and the expression of genes involved in dopaminergic neurotransmission in the

74 ared by all three fragments, including known genes involved in early phases of the adenoma-carcinoma

75 Our aim was to detect new interacting genes involved in eczema.

76 ivo is accompanied by the down-regulation of genes involved in embryonic development and vasculogenes

77 ll) cells, associated with downregulation of genes involved in EMT, tumor invasion, and metastasis.

78 hich VEC triggers the expression of a set of genes involved in endothelial differentiation and vascul

79 ting that indole decreases the expression of genes involved in energy and amino acid metabolism, the

80 Ps were present in microRNA-binding sites of genes involved in energy metabolism and muscle structure

81 rotection is connected with the induction of genes involved in energy metabolism, detoxification and

82 48%) were confirmed by qPCR corresponding to genes involved in epidermal homeostasis and dermal repai

83 Other mutations in genes involved in epigenetic regulation, splicing, and s

84 HPV downregulated many genes involved in epithelial barrier function, which inv

85 e (UPR), which alters the expression of many genes involved in ER quality control.

86 The genes involved in ethylene biosynthesis were differentia

87 y reduced SREBP-1c and the expression of all genes involved in FA and triglyceride synthesis that are

88 essing cells identified the up-regulation of genes involved in Fas-mediated cell death, and Erdr1 fai

89 mbers of cytochrome P450 (CYP450) family and genes involved in fatty acid beta-oxidation and omega-ox

90 scription factors activate expression of the genes involved in fatty acid oxidation.

91 Arrested cells up-regulate most genes involved in fatty acid synthesis, including acetyl

92 ls reveals the key regulatory and structural genes involved in fibre formation.

93 In the atria, MEF2A regulated genes involved in fibrosis and adhesion, whereas in the

94 indicated up-regulation by mycorrhization of genes involved in flavonoid, terpenoid, jasmonic acid (J

95 ome arms to suppress conditionally expressed genes involved in flowering or DNA repair, including the

96 ons and gene fusions, were commonly found in genes involved in four main pathways: chromatin remodell

97 Using functional genomics, we identify new genes involved in fungal complexification.

98 interaction and identification of important genes involved in G. arboreum tolerance against CLCuD.

99 ive stress and coordinates the regulation of genes involved in GAS antioxidant defenses.

100 Single nucleotide polymorphisms of genes involved in GC signaling (GR, GLCCI1) and drug met

101 odgkinia lineage retains a small set of core genes involved in genetic information processing, but th

102 components, encapsulating more interactions/genes involved in glucocorticoid receptor signalling.

103 ificantly increased the expression levels of genes involved in gluconeogenesis in the liver and the k

104 retina and there is increased expression of genes involved in glucose metabolism, which led to chron

105 We found extensive binding of PPARalpha near genes involved in glycolysis/gluconeogenesis and uncover

106 ent and vasculogenesis, and up-regulation of genes involved in hematopoietic organ development, lymph

107 factor, MdMYB39L, and of its putative target genes involved in hexose uptake, cell wall formation and

108 rogrammed in aged stem cells, switching from genes involved in homeostasis to those involved in tissu

109 o regulate the expression of numerous target genes involved in hormone metabolism and growth processe

110 In addition, RNA-seq analysis revealed that genes involved in hormone signaling pathways, defense re

111 Many genes involved in host defense were induced by IL-17 in

112 tance in groundnut, the study identified the genes involved in host-pathogen cross-talks and markers

113 etermination of changes in expression of key genes involved in human sex-differentiation is defined,

114 In the absence of Plag1, a number of genes involved in immune processes and epididymis-specif

115 n studies reveal that variants in many human genes involved in immunity and gut architecture are asso

116 he miRNA pathway affecting the expression of genes involved in immunity, defense, and development.

117 at EHF targets in HBE cells are enriched for genes involved in inflammation and wound repair.

118 expression changes, regulatory regions near genes involved in inflammatory response displayed decrea

119 e resulted in a strong induction of multiple genes involved in inflammatory responses and mobilizatio

120 With the exception of genes involved in information processing, particularly t

121 associated with promoters were enriched for genes involved in intestinal development, including home

122 nal epithelial cells lead to derepression of genes involved in intestinal maturation and bilirubin de

123 hree microRNAs revealed enrichment of target genes involved in key aging and longevity pathways inclu

124 purifying selection and are associated with genes involved in key keratinocyte and skin-centric biol

125 Of these DMGs, many are critical genes involved in learning and memory, such as Creb, GAB

126 tributes to diabetic nephropathy by inducing genes involved in leukocyte infiltration, cell prolifera

127 The methylation loci identify genes involved in lipid and lipoprotein metabolism, subs

128 letal muscle lipid profiles and up-regulated genes involved in lipid catabolism, while decreasing 241

129 Genes involved in lipid metabolism, especially omega-6 f

130 ed receptor delta (PPARdelta) regulates many genes involved in lipid metabolism.

131 morning fasting increases the expression of genes involved in lipid turnover (ACADM) and insulin sig

132 on factor EB (TFEB) through the induction of genes involved in lysosomal biogenesis and exocytosis.

133 ex and the v-ATPase proton pump, whereas Atg genes involved in macroautophagy are dispensable for cri

134 Additionally, multiple genes involved in maintaining the mitotic cell cycle wer

135 We studied the chromosomal organization of genes involved in male reproductive development in Arabi

136 is a key transcription factor that regulates genes involved in mammary luminal cell differentiation a

137 on factors (TFs) that modulate expression of genes involved in many physiological and pathological co

138 ents, we showed significant dysregulation of genes involved in MAPK/Wnt signalling pathways.

139 Several evolutionary strata did not include genes involved in mating-type determination.

140 can be explained by decreased expression of genes involved in mature neuron function, along with inc

141 Genes involved in MDSC suppressive functions, including

142 To identify genes involved in MeCP2 silencing, we screened a library

143 DNA methylation changes were identified at genes involved in melanocyte biology, such as RAF1 (P =

144 as accompanied by the down-regulation of key genes involved in meristem development as the autumn pro

145 s neural differentiation while up-regulating genes involved in mesodermal lineage decisions.

146 exposure also reduced the mRNA expression of genes involved in metabolic pathways in gonadal adipose

147 romatin modifiers regulate the expression of genes involved in metabolism and, in turn, the levels of

148 ents, as indicated by the down-regulation of genes involved in metal homeostasis and transport and th

149 sophila SIN3 binds to the promoter region of genes involved in methionine catabolism and that this bi

150 We additionally identified genes involved in microbial competition and cooperation

151 both in vivo and in vitro and down-regulates genes involved in migration and proliferation of endothe

152 ow RB expression revealed high enrichment of genes involved in mitochondrial respiration and downstre

153 crease in the expression of the AMPK cascade genes, involved in mitochondrial biogenesis and antioxid

154 y targeting G1-S transition genes as well as genes involved in mitosis and cytokinesis such as CHFR,

155 alters the splicing of transcripts for host genes involved in mRNA posttranscriptional modifications

156 Rather than transcriptional factors, genes involved in mRNA translation are highly represente

157 challenge nor was there any up-regulation of genes involved in multi-xenobiotic resistance (MXR) or d

158 ule 1 and vascular cell adhesion molecule 1) genes involved in myeloid cell recruitment was reduced i

159 diation enteropathy mouse model confirm that genes involved in N- and O-glycosylation are modulated b

160 de known ASD genes (SHANK3, CDH10, CSMD1) or genes involved in nervous system development (NYAP2, ST6

161 The introgressed regions are enriched in genes involved in nervous system development and functio

162 cross the latitudinal gradient and implicate genes involved in nervous system function.

163 Genes involved in NET formation in the animal model were

164 on loss of HMGNs leads to down regulation of genes involved in neural differentiation, and that the t

165 ested that CLOCK regulates the expression of genes involved in neuronal migration, and a functional a

166 tion, 35S::SbMyb60 altered the expression of genes involved in nitrogen (N) assimilation and carbon (

167 -scheduling of diel transcript expression of genes involved in nocturnal CO2 fixation, stomatal movem

168 ected based upon their lengths, include many genes involved in nucleosome and chromatin formation, an

169 4GALT3, USMG5, P2RY13, and P2RY14, which are genes involved in nucleotide synthesis or nucleotide-dep

170 We also show that GPATCH3 is a new gene involved in ocular and craniofacial development.

171 r and there was striking overlap between the genes involved in OGID and 260 somatically mutated cance

172 There was significant overlap between the 14 genes involved in OGID and 611 genes in regions identifi

173 However, the mutation spectra of genes involved in OGID and cancer differ, suggesting com

174 hat a common variation impacting function of genes involved in OGID influences height at a population

175 ven GO analysis suggests lower expression of genes involved in oligodendrocyte differentiation, regul

176 pression of enhancer target genes, including genes involved in oncogenesis and blood cell development

177 addition, we find that a large proportion of genes involved in oncogenic translocations overall conta

178 volved in genome stability and expression of genes involved in oxidative stress responses, tumor prog

179 P limitation showed increased expression of genes involved in P uptake and an expansion of the P sub

180 lerosis patients suggesting a novel class of genes involved in pathogenesis of systemic sclerosis.

181 is review we have analysed the occurrence of genes involved in peptidoglycan metabolism across the ma

182 esses deletions in most, but not all (mltG), genes involved in peripheral PG synthesis and in the gps

183 strains revealed a CopR regulon composed of genes involved in periplasmic Cu(+) homeostasis and its

184 We detect signals of positive selection for genes involved in peroxidase and hypoxia to enable its h

185 d that Mertk and its ligand Gas6, astrocytic genes involved in phagocytosis, are upregulated after ac

186 m/phosphorus levels and affect expression of genes involved in phosphate homeostasis.

187 more likely to be lichen associated and have genes involved in photosynthesis and radiation resistanc

188 responses, such as up-regulation of multiple genes involved in Pi uptake and solubilization, accumula

189 Genes involved in pigmentation, including those for the

190 rtant for infectivity (eg, the pilT and galU genes involved in pilus motility and LPS formation).

191 munities with the highest abundances of many genes involved in prokaryotic C degradation, ammonificat

192 Shc and Gab-1 and more potent regulation of genes involved in proliferation, corresponding to their

193 ely spliced transcripts of a subset of these genes, involved in proliferation and tumor cell migratio

194 Mutations in genes involved in R-loop resolution or mutations leading

195 responsible for regulating the expression of genes involved in RBC invasion.

196 lp to elucidate the evolution of polymorphic genes involved in Red Queen co-evolution.

197 ol will be useful for identifying additional genes involved in regulating this transcription factor c

198 26 single nucleotide polymorphisms (SNPs) in genes involved in regulation of neurotransmitter systems

199 ted to target sites that are associated with genes involved in regulation of pluripotency, and these

200 er, these results identify miR-7a2-regulated genes involved in reproductive hormone biosynthesis path

201 Genes involved in reprogramming, imprinting and developm

202 ns, with the former leading to enrichment of genes involved in response to toxic stress and detoxific

203 l for maintaining proteostasis; many are hub genes - involved in RNA processing, cytoskeletal metabol

204 tive deletions are significantly enriched in genes involved in RNA metabolism.

205 irus-infected bees had greater expression of genes involved in RNAi, Toll, Imd, and JAK-STAT pathways

206 we provide evidence that mutations affecting genes involved in RNR substrate production can cause dNT

207 For obtaining insights into genes involved in SA-induced folate accumulation, microa

208 a change in the repertoire and expression of genes involved in salt acclimation.

209 s were assigned annotations, and 936 and 220 genes involved in salt response in roots and leaves, res

210 l nitrogen (N) and phosphorus (P) stress, as genes involved in scavenging of these nutrients were bei

211 Novel genes involved in secondary metabolism, including genes

212 both transcription factors and biosynthesis genes involved in secondary wall formation, leading to t

213 Genes involved in secretion are up-regulated during cyst

214 progenitor cells to control transcription of genes involved in self-renewal and differentiation.

215 ntly affected neurological pathways included genes involved in serotonergic, cholinergic, dopaminergi

216 e sensitized to immunotherapy by deletion of genes involved in several diverse pathways, including NF

217 he largest of these regions are enriched for genes involved in siderophore acquisition, and are widel

218 MapMan analysis indicated that genes involved in signaling, hormone, cell wall, and bio

219 Genes involved in sleep control code for ion channels, f

220 DICER-LIKE (DCL), ARGONAUTE (AGO), and other genes involved in small RNA pathways, predicted over 260

221 ted a separation of expressional changes for genes involved in specific aspects of cardiac remodeling

222 ranscriptional analysis revealed 4 important genes involved in sphingolipid metabolism to be deregula

223 id in the presence of recessive mutations in genes involved in stability and polyadenylation of RNA.

224 al to genes implicated in liver cancer or to genes involved in stem cell development, the latter dist

225 ssed rodents, and identified a set of target genes involved in stress response and neural plasticity.

226 concomitant with an increased expression of genes involved in stress response.

227 ls and/or gene number expansion for multiple genes involved in stress responses and the biosynthesis

228 regulates expression of other VRS genes, and genes involved in stress, hormone and sugar metabolism.

229 showed the functional metabolic potential of genes involved in stress, virulence, sulfur cycle, metal

230 nt also showed altered expression of various genes involved in such cellular and developmental pathwa

231 negatively correlated with the abundance of genes involved in sulfur cycle, virulence, and stress re

232 assively parallel DNA sequencing showed that genes involved in synaptic communication are epigenetica

233 lities are common; for example, variation in genes involved in synaptic homoeostasis are implicated i

234 nd widespread transcriptional alterations in genes involved in synaptic signaling, a number of which

235 in the largest GWAS to date, associated with genes involved in synaptic transmission.

236 ion of normal B cells, show up-regulation of genes involved in T-cell signaling, and give rise to mix

237 led to changes in the expression of several genes involved in TCR signaling and cell activation, con

238 and telomerase reverse transcriptase (TERT), genes involved in telomere regulation and function, play

239 These data suggest that the MC4R may be one gene involved in the evolution of feeding ecology, energ

240 VI which was predicted to co-localize with a gene involved in the metabolism of glycoproteins in resp

241 aggregate, our findings implicate MYLK as a gene involved in the recessive form of MMIHS, confirming

242 the functional conservation of JAGGED, a key gene involved in the sculpting of lateral organs in seve

243 We identified a number of candidate genes involved in the ABA signaling pathway, as well as

244 Among other genes involved in the alpha-DG glycosylation process, fu

245 articipate in the transcriptional control of genes involved in the biosynthesis of maize phenolic com

246 For further identification of the CYP450s genes involved in the biosynthesis of MG secretions, we

247 Based on the presumed function of homologous genes involved in the biosynthesis of thioviridamide, a

248 aerobic electron transport chain (ETC), only genes involved in the biosynthesis of ubiquinone, an ele

249 e production of aromas and identify the main genes involved in the biosynthetic pathways switched on

250 Recently, an array of eight genes involved in the biotransformation of benzalkonium

251 ch is supported by the reduced expression of genes involved in the chlorophyll degradation pathway.

252 tion, perhaps due to increased expression of genes involved in the control of cell proliferation and

253 ell lines to provide a genome-wide survey of genes involved in the control of L1 retrotransposition.

254 O) cells show significant down-regulation of genes involved in the development and function of normal

255 lamin B1 regulates expression of a subset of genes involved in the differentiation of a specific cell

256 We show a significant overexpression of genes involved in the DNA damage response, specifically

257 n be caused by loss-of-function mutations in genes involved in the DNA recombination machinery, such

258 turation-stage amelogenesis by targeting key genes involved in the endocytotic and endosomal/lysosoma

259 hronic hyperglycemia to impair expression of genes involved in the establishment of the blood-brain b

260 mmediately after mitosis primarily activates genes involved in the growth and rebuilding of daughter

261 e needed to investigate the role of specific genes involved in the identified pathways and their poss

262 and targeted SNP analyses of other candidate genes involved in the immune response to malaria have no

263 n of functionally important genes; including genes involved in the inflammatory response, cell prolif

264 research on cryptococcal pathogenesis, host genes involved in the initial engulfment of fungi and su

265 monly altered [37.8% (167/442)], followed by genes involved in the MAPK pathway [31.2% (138/442)], PI

266 icult, in contrast to the well-characterized genes involved in the melanogenesis pathways.

267 erious variants in NOTCH receptors and other genes involved in the NOTCH signalling pathway.

268 Further analyses on several developmental genes involved in the photoreceptor cell differentiation

269 we used phylogenetic analyses of the vision genes involved in the phototransduction pathway to predi

270 In particular, many genes involved in the process in Arabidopsis (Arabidopsi

271 asm associated with somatic mutations in the genes involved in the RAF/MEK/extracellular signal-regul

272 lso have a large presence of phage genes and genes involved in the recycling of cellular material.

273 alterations in methylation and expression of genes involved in the regulation of energy homeostasis w

274 Analyses focused on probes in 114 target genes involved in the regulation of inflammation, and we

275 pression results in changes in expression of genes involved in the regulation of intracellular calciu

276 ion, we carried out a genome-wide screen for genes involved in the release of extracellular DNA (eDNA

277 ression of the plastid nitrite reductase and genes involved in the subsequent incorporation of ammoni

278 both strains demonstrate a de-regulation of genes involved in the SurR regulon, including hydrogenas

279 viduals in a multiplex TD family to discover genes involved in the TD etiology.

280 ymbiosis of a repertoire of fungal and plant genes involved in the transport and metabolism of N comp

281 yses reveal lineage-specific duplications of genes involved in the transport of nutrients to developi

282 ates in amino acid homeostasis by regulating genes involved in their utilization or biosynthesis.

283 the heart, and upregulation of FGF21-target genes involved in thermogenesis and fatty acid oxidation

284 The expression of key genes involved in these metabolic pathways was significa

285 ite decades of work aimed at identifying the genes involved in these two illnesses, virtually no prog

286 However, genes involved in this process have been identified in o

287 To identify genes involved in this process we performed a microarray

288 s within promoters and regulatory regions of genes involved in TLR signaling in resting UCB monocytes

289 of differentially methylated CpG sites found genes involved in transcription factor activity, protein

290 Key candidates identified include genes involved in transcription, chromatin remodeling, p

291 dinates with up-regulation of expression for genes involved in translation during cell proliferation.

292 upregulates expression of a large number of genes involved in translation initiation, cell cycle, DN

293 ose tissues of mice, reducing mRNA levels of genes involved in triglyceride synthesis.

294 cate that copy number variation (CNV) alters genes involved in tumor progression; however, identifica

295 ques, many additional mutations in different genes involved in ubiquitination and related to immune s

296 Genes involved in various functions including oxidative

297 CR4 mutations and includes overexpression of genes involved in VDJ recombination, CXCR4 pathway signa

298 Thus, common genetic variants located near genes involved in vitamin D metabolism and calcium and r

299 rs/SEs and lncRNAs to increase expression of genes involved in VSMC dysfunction, and could uncover no

300 ntification of novel roles for characterized genes involved in xylan and cellulose biosynthesis, regu