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1 tial for H3K9me2 demethylation at cell cycle gene loci.
2 he unrearranged human H chain and L chain Ig gene loci.
3 3100, JQ1 disrupted AR recruitment to target gene loci.
4 covered in numerous T cell lineage-expressed gene loci.
5 g forms or boundary element function at tRNA gene loci.
6 d the generality of this finding to numerous gene loci.
7 -3 on histone 4 (H3K4me3) at flower MADS box gene loci.
8 II (MHC II) in mice containing the human TCR gene loci.
9 domains spliced from adjacent SH3BP1 and CIN gene loci.
10 e loss of tumor suppressors p53 and cadherin gene loci.
11 interaction with specific regions of U snRNA gene loci.
12 marks and increases H3K4me3 marks on target gene loci.
13 approximately 20% were antisense to the host gene loci.
14 training mixed set consisting of 50% of the gene loci.
15 nkage analysis identified potential modifier-gene loci.
16 ngle-base mutations are achieved in multiple gene loci.
17 ne, we find evidence for at least three vasa gene loci.
18 of H3.3 incorporation at activity-dependent gene loci.
19 ements within the globin and other erythroid gene loci.
20 Egr1 in promoter regions of many cholesterol gene loci.
21 f modified cytosines to cytosines at several gene loci.
22 associated with transcriptional activity at gene loci.
23 tem/progenitor enhancers in the FLI1 and ERG gene loci.
24 ng enzyme interaction and remodeling at late-gene loci.
25 nomic DNA surrounding the DHFR, Hsp70, or MT gene loci.
26 om, as many of them are associated with tRNA gene loci.
27 t can be readily adapted to include multiple gene loci.
28 d DNA integration into transgenic and native gene loci.
29 tion drives spatial organization at specific gene loci.
30 sing of transcripts originating from histone gene loci.
31 d MBD10 in the large-scale silencing of rRNA gene loci.
32 o 1000-times increased in tri-partite immune gene loci.
33 orphisms at the FcgammaRIIa and FcgammaRIIIa gene loci.
34 erformed using probes to the four functional gene loci.
35 tion of stable epigenetic histone 'marks' at gene loci.
36 has been limited to proximal regions around gene loci.
37 s scored at 196 microsatellite and candidate gene loci.
38 the levels of diMe-H3K4 and Ac-H3K9 at CG-X gene loci.
39 or of transposon insertions in 758 different gene loci.
40 d compared to associate them with particular gene loci.
41 earance of RNA polymerase II from the target gene loci.
42 hip between PML bodies and the TP53 and BCL2 gene loci.
43 rmation of stable Polycomb domains at target gene loci.
44 the presence of allelic polymorphisms in few gene loci.
45 ms of known genes and 3% correspond to novel gene loci.
46 orchestrates the chromatin landscape of SASP gene loci.
47 ding of repressive heterochromatin into SASP gene loci.
48 combine their TCR beta-chain and gamma-chain gene loci.
49 aBp65 was bound on both miR-155 and miR-146a gene loci.
50 n of chromosome translocations of endogenous gene loci.
51 ere, centromere, G-rich telomere, and coding gene loci.
52 r of nascent mRNAs synthesized at individual gene loci.
53 q datasets using different methods to define gene loci.
54 lified by their actions at the Runx2 and Sp7 gene loci.
55 lecithin cholesterol acyltransferase (LCAT) gene loci.
56 involving a total of 53 polymorphisms in 28 genes/loci.
57 oring highly methylated and silenced mir-124 gene loci, 5-azacytidine treatment allowed miR-124 re-ex
58 e we investigate genetic variation of 12 PAI gene loci (7 on T-PAI and 5 on S-PAI) in 96 worldwide is
61 ncreased CncC binding at the Jheh and dKeap1 gene loci and activated their transcription, whereas dKe
62 ation requires remodeling of tissue-specific gene loci and activities of key transcriptional regulato
64 obases of human genome sequence from diverse gene loci and cleanly delineated functional elements cor
67 atin assembly at retroelements and regulated gene loci and facilitates the formation of constitutive
68 een restricted in size from one to two dozen gene loci and have not decisively resolved the basal bra
69 f folding for proteins encoded at homozygous gene loci and higher concentrations of potentially aggre
70 sult of difficulties in resolving individual gene loci and in detecting the small number of protein m
71 as identified more than 100 plant resistance gene loci and linked molecular markers used in cultivar
72 fate is determined by Cd4 and Cd8 coreceptor gene loci and not by the specificity of T-cell antigen r
75 relation to organization and positioning of gene loci and regulation of chromatin organization throu
76 nates noncoding DNA sequences that interrupt gene loci and reorganizes the remaining fragments by inv
79 foci that localize to the endogenous chorion gene loci and to active transgenic constructs at the beg
80 thylation marks in the context of endogenous gene loci and validate programmable DNA demethylation re
81 STAT3 bound directly to Th2 cell-associated gene loci and was required for the ability of STAT6 to b
82 ne testing for possible associations between genes, loci and traits of interest by an entire research
83 tylated domains within mammalian beta-globin gene loci, and determined that within the murine locus,
85 te into mature neurons, REST leaves miR-124a gene loci, and nonneuronal transcripts are degraded sele
86 NuRD) complex at the neurogenesis-associated gene loci, and, as a consequence, increasing acetyl hist
88 frequency of point mutations at the reporter gene loci Aprt and Hprt, on the other hand, is significa
90 trate that DNA methylation marks in specific gene loci are associated with asthma and suggest that ep
93 dy or translocations into the immunoglobulin gene loci are considered as initiating events in the pat
94 n structure of Drosophila melanogaster Hsp70 gene loci are dependent on the transcriptional activator
96 gastritis tissues indicated that the mir-124 gene loci are more heavily methylated in a Colombian pop
97 constitutive and alternative nucleotides in gene loci are nearly identical, their distribution along
102 wn to occupy AP-1 binding sites within these gene loci, as determined by chromatin immunoprecipitatio
104 ive H3K27me3 modifications is a signature of gene loci associated with gene transcription, replicatio
107 somal colocalization of miR-155 and miR-146a gene loci at the stage of endotoxin tolerance, whereas R
109 and relocation of the keratinocyte-specific gene loci away from the sites of active transcription to
111 y as structural elements on the periphery of gene loci, but as regulatory elements that are crucial t
112 1, LMO1, DUSP12, HSD17B12, HACE1, and LIN28B gene loci, but these explain only a small fraction of ne
113 od for directing DNA methylation to specific gene loci by conjugating catalytic domains of DNA methyl
115 including their propensity to acquire novel gene loci by horizontal genetic transfer, as well as the
116 ously uncharacterized candidate colonization gene loci by making independent null alleles and have co
117 rearrangements at immunoglobulin heavy chain gene loci by transcriptionally activating the Rag1 and R
118 ation of each of the seven MLST housekeeping gene loci by using the same primer pairs used in MLST.
119 components from alphabeta and gammadeltaTCR gene loci can recombine to confer Ag specificity, thus e
120 IFN-gamma) and interleukin 4 (IL-4) cytokine gene loci, changes that are heritably maintained in the
121 ition from MyoD to myogenin occurred at late gene loci, concomitant with loss of HDAC2, the appearanc
124 netic disruptions of the Ikkbeta or Ikkgamma gene loci die during embryogenesis because of severe hep
125 files and nuclear positions at developmental gene loci differ between human somatic cells and hPSCs,
126 specific epigenetic modifications at target gene loci, directly upregulating metastasis-associated g
128 proteins regulate three of the four histone gene loci during the Saccharomyces cerevisiae cell cycle
130 Teb2 and Teb3 expressed at their endogenous gene loci enabled affinity purifications that revealed t
132 ofiling in preadipocytes, we find that among gene loci encoding adipogenesis regulators, histone meth
133 f development, before B cell maturation, the gene loci encoding the heavy and light chains of immunog
135 ess variable expression; (iii) less variable gene loci evolve under purifying selection against copy
136 n nuclei, a select number of tissue-specific gene loci exhibit broadly distributed patterns of histon
137 hat transcribed regions of the ribosomal RNA gene loci exhibit rapid exchange of H3/H4 tetramers.
138 ned within the nuclear space, and individual gene loci experience distinct local environments due to
139 nitors in the marrow have rearranged the TCR gene loci, express Valpha and Vbeta genes as well as CD3
140 The co-expression is most prominent when two gene loci fall within 1,000 base pairs from the observed
141 correlated fluctuations in the positions of gene loci, find large genomic compartments and smaller t
144 These loci will provide unbiased candidate gene loci for evaluation in human case-control associati
147 amp enables targeting to a greater number of gene loci for stronger occupancy and transcription regul
149 the Ab repertoire are retained: the numerous genes/loci for ligand-binding diversification and the po
150 tin spreading to allow for exclusion of SASP gene loci from a global heterochromatin environment duri
151 most recent common ancestor at four neutral gene loci from Asian and South American isolates (a mini
153 c regulation through in situ switching among gene loci, further expanding the potential repertoire of
154 to sweep through the population at selected gene loci (gene-specific sweeps), or the recombination r
155 nt transcription beyond known protein-coding gene loci, generating a variety of RNA classes, most of
156 hat diversification at particular gammadelta gene loci has been favored during primate evolution, sug
157 e configuration and rearrangements of the Ig gene loci has contributed extensively to our understandi
159 i were used to estimate the rates with which gene loci have been deleted and duplicated during the ev
163 ipitation assays analyzing the corresponding gene loci identified unusual STAT5 binding sites compare
164 ed cause, there are now eight separate human gene loci identified whose mutations result in this dise
166 tions at known DBA-related ribosomal protein gene loci in 17% (9 of 51) of patients without an identi
169 stone gene transcripts colocalize at histone gene loci in dedicated subnuclear foci (histone locus bo
173 lease at three disease-associated endogenous gene loci in HEK293T cells, HeLa cells, and human induce
176 protocol to knock in a GFP cassette into key gene loci in human pluripotent stem cells (hPSCs), and t
177 particular, >30% of the approximately 800 OR gene loci in humans were polymorphic with respect to cop
179 shown to stimulate recombination in reporter gene loci in mammalian cells via site-specific binding a
180 preset chromatin structure of the cis-linked gene loci in oocytes and adult stem/progenitor cells.
181 e (miRBase 16) contains over 15,000 microRNA gene loci in over 140 species, and over 17,000 distinct
184 the classical DHA is constrained to mapping gene loci in small increments of approximately 20 kb.
186 sequence span varies greatly among different gene loci in the human genome and longer loci have a hig
187 lase inhibitor promotes accessibility at key gene loci in the MG, and allows more effective reprogram
188 ipt, strong depletion of H3K27me3 at escaper gene loci in the present study suggests that histone sta
190 evealed significant enrichment of methylated gene-loci in Cell Cycle Regulation, DNA Damage Response,
191 itive DNAs associated with 3,000-4,000 human gene loci including the beta-globin gene locus where the
192 even the co-location of functionally related gene loci, including early replication start sites and t
193 ecruitment along a number of immediate early gene loci, including EGR1 and ZFP36, with the highest de
194 ced the levels of H3K4me3 at critical B-cell gene loci, including Pax5 and Rag1/2, which are critical
195 o occur in approximately 40% of the detected gene loci, including several involved in isoprenoid/terp
196 ined two strain populations differing at 113 gene loci, including the cag pathogenicity island virule
197 and Yta7 differed markedly among the histone gene loci, including the two H3-H4 histone gene pairs.
198 A3B and EBNA3C binding at multiple regulated gene loci, indicating a requirement for CBF heterodimers
201 an cells, the replication of tissue-specific gene loci is believed to be under developmental control.
202 ndings show that hypermethylation of certain gene loci is controlled in part by an underlying suscept
203 zation of histone modifications at imprinted gene loci is incomplete, and whether specific histone ma
207 or and/or memory CTLs, the majority of these gene loci lose repressive H3K27me3 while retaining the p
208 ive MethyLight assay, six of the 55 examined gene loci (LTB4R, MTHFR, CDH13, PGR, CDH1, and IGSF4) we
209 hly similar genes in the lymphocyte receptor gene loci makes them difficult to investigate, and the d
211 lytic transcripts derived from these latency gene loci may have unique, noncoding nuclear functions d
214 d evidence of association at four additional gene loci: MMEL1-TNFRSF14 (rs3890745, P = 0.0035 replica
215 ntly contains deletions of tumour suppressor gene loci, most notably SMAD4, which is homozygously del
216 osomes (karyotype), number of protein-coding gene loci, number of transcription factors, guanine-cyto
217 asis for serotype 6C, we studied the capsule gene loci of 14 6C isolates from three different contine
218 vestigating the nucleotide diversity at five gene loci of a large sample that represents the entire g
219 a homozygous deletion polymorphism in the M1 gene loci of glutathione S-transferase (GSTM1-null) in a
220 ward, it is unclear as to whether particular gene loci on chromosome 21 (HSA21) are sufficient to cau
221 f movement between two fluorescently labeled gene loci on either the same or different budding yeast
222 ffects of linear and spatial organization of gene loci on gene regulation are linked through TAD arch
225 ganization of the nucleoid, with movement of gene loci out of the bulk of DNA as levels of transcript
226 nsights into nuclear function would arise if gene loci physically interacting with particular subnucl
228 ee WRKY factors each bound to more than 1000 gene loci predominantly at W-box elements, the known WRK
229 ity) joining [V(D)J] recombination of immune gene loci proceeds in an ordered manner with D to J port
230 osequencing detected transcription of 17,449 gene loci providing very deep coverage of the transcript
231 e nine clones represent nine different actin gene loci rather than different alleles or different par
232 transposons R1 and R2 have persisted in rRNA gene loci (rDNA) since the origin of arthropods despite
234 e mechanisms underpinning KLF1 action at the gene loci regulating the first 3 steps in this process,
240 two proteins, Chp1 and Sap (corresponding to gene loci rv3822 and rv3821), that complete this pathway
241 nd to differentiation signals, developmental gene loci should be structurally and spatially regulated
242 sense transcripts at some of the EBV latency gene loci showed that they are "late" genes, they are nu
243 target genes, and phasiRNA-generating (PHAS) genes/loci showed that the function of miR482/2118 has e
246 ethylated H3K9 modifications at the receptor gene loci, suggesting a mechanism for silencing receptor
247 n ability and MLL1 recruitment to the target gene loci, suggesting that PHD2 negatively regulates MLL
252 iations of a total of 1251 alleles of all 40 gene loci that together are known to affect antigens of
253 histone mark at a significant proportion of gene loci that undergo daily transcription, implicating
254 ver tumor nodules and identified at least 16 genes/loci that contribute to accelerated tumor developm
257 volutionary novel A alleles of the both OXTR gene loci, that the spread of alleles of rs22542298 and
258 lated strains that vary at a small number of gene loci, that this population of strains may already b
259 using both anonymous markers and functional gene loci, that will enable the localization of quantita
260 e to an increase in H3K27me3 marks at stress gene loci, the timing of which is determined by reduced
262 regulating H3K9 demethylation at cell cycle gene loci, thereby representing a key player in oncogene
263 Focusing on approximately 1,700 conserved gene loci, those that have the more slowly evolving codi
264 PK may play a role in recruitment of XRN2 to gene loci thus regulating coupling 3'-end pre-mRNA proce
265 repressive chromatin modifications at these gene loci, thus maintaining the potential for expression
267 nce approach to detect resistance-associated gene loci to improve our mechanistic understanding of ho
268 hPSCs from studying the impact of individual gene loci to investigation of multigenic human traits, a
269 s of in vivo chromatin structure over entire gene loci to rapidly and precisely localize cis-regulato
270 e human genome could activate the cis-linked gene loci to synthesize maternal mRNAs required for earl
271 itiation and elongation, and localization of gene loci to transcription factories in the nucleus.
272 teins were inserted into the Rex1 and Oct3/4 gene loci to visualize the expression of these genes.
274 cells into effector cells, specific cytokine gene loci undergo extensive changes in chromatin modific
275 o transcriptional competence at Th2 cytokine gene loci upon recall activation indicates that linear d
277 ddress PfCCp function, the PfCCp2 and PfCCp3 gene loci were disrupted by homologous recombination, re
280 conditions, the regulatory sequences of late gene loci were not in close proximity, and these genes w
282 t the stage of endotoxin tolerance, both miR gene loci were occupied by C/EBPbeta, NFkappaBp50, and t
284 timates and the evolutionary history of 3159 gene loci were used to estimate the rates with which gen
286 arrays, leading to the identification of 445 gene loci where SF-1-binding regions were located from 1
287 hat SAFB1 acts as a novel AR co-regulator at gene loci where signals from the MST1/Hippo and EZH2 pat
288 over, we also demonstrate that developmental gene loci, which have bivalent histone modifications, te
289 DNA damage and loss of key tumor suppressor gene loci, which in combination can initiate tumorigenes
290 ethylation of Lys9 of histone H3 at specific gene loci, which is associated with transcriptional repr
291 CBs associate non-randomly with U1 and U2 gene loci, which produce the small nuclear RNA (snRNA) c
292 chromatin-remodeling of both Nanog and Oct4 gene loci, which requires RA receptor-alpha, RIP140 and
293 omeZipper incorporates 4,035 conserved grass gene loci, which were used for the first genome-wide seq
299 g-tagged primers simultaneously probe 16 p53 gene loci, with an abbreviated thermal cycling protocol
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