ライフサイエンスコーパス: gene promoter

1 ibited the transcriptional activity of Smad3 gene promoter.

2 could bind and control activity of the SRSF1 gene promoter.

3 DEAD (Asp-Glu-Ala-Asp) box protein 4 (Ddx4) gene promoter.

4 orresponding to its binding site in the IL-2 gene promoter.

5 n directly and does not catalyze 5hmC at the gene promoter.

6 by visualizing the activity of an early euo gene promoter.

7 to SMAD binding elements (SBEs) in the DSPP gene promoter.

8 reduction occurred at the level of the fosB gene promoter.

9 B interrupts an E-box consensus motif in the gene promoter.

10 cific site just downstream of the phage late-gene promoter.

11 cts DNA binding differently depending on the gene promoter.

12 induced gene expression from an MHC class II gene promoter.

13 ce repressive chromatin modifications in the gene promoter.

14 late a NF-kappaB response element in the Shh gene promoter.

15 he control of the pancreas duodenal homeobox gene promoter.

16 volving an activator protein 1 site in MMP10 gene promoter.

17 coding tumor protein 53) binding to the HPSE gene promoter.

18 y specific mutations in the rrs gene and eis gene promoter.

19 rough NFATc1-mediated regulation of the CD23 gene promoter.

20 like3 and OsNIN-like4) binding to the OsNHX1 gene promoter.

21 e complexity of methylation changes around a gene promoter.

22 t chromatin remodeling complexes to the Ifng gene promoter.

23 pha (hREG3A) in hepatocytes, via the albumin gene promoter.

24 factor 1 alpha subunit (HIF1A) in the VEGFA gene promoter.

25 colitis suppresses the activity of the St14 gene promoter.

26 tified an FXR-responsive element on the Tgr5 gene promoter.

27 d protein expression by binding to the DOT1L gene promoter.

28 interacts with TRF2 to recruit it to the RP gene promoter.

29 transcription factor FoxM1 on the cyclin B1 gene promoter.

30 aB translocation and binding to inflammatory gene promoters.

31 ription factor NF-kappaB to pro-inflammatory gene promoters.

32 ) at NF-kappaB binding sites on inflammatory gene promoters.

33 enhancers, they largely bind together at MCC gene promoters.

34 uppressed activation of several M. sexta AMP gene promoters.

35 onal algorithm to pair enhancers with target gene promoters.

36 amics of interactions between regulators and gene promoters.

37 for linking distal regulatory elements with gene promoters.

38 anscription factor (TF) binding sites in the gene promoters.

39 cells demonstrated that IFI16 binds to KSHV gene promoters.

40 active enhancers already in interaction with gene promoters.

41 nuclei triggered immediate binding to target gene promoters.

42 n factors than liver-specific protein-coding gene promoters.

43 ping the DNA methylation landscape away from gene promoters.

44 repress transcription assemble on epithelial gene promoters.

45 educed Zeb2 and Snail1 binding to epithelial gene promoters.

46 he association of MED15 with six WRI1 target gene promoters.

47 to repress the activity of vehgr1 and vegfr2 gene promoters.

48 reduced-representation (RR)-MAB-seq) such as gene promoters.

49 d with a particular set of key developmental gene promoters.

50 s, including p130/p107, still bind to target gene promoters.

51 e indirect tethering of LXRs to inflammatory gene promoters.

52 f transcriptional complex assembly on target gene promoters.

53 ent derepression or activation of associated gene promoters.

54 ls, while showing a significant depletion in gene promoters.

55 anscription factor off of a subset of target gene promoters.

56 of p63 and p73 by mutant p53 at their target gene promoters.

57 which reduces binding of p65 to inflammatory gene promoters.

58 DNA hypermethylation of miR-148a and miR-152 gene promoters.

59 th of repetitive DNA elements located within gene promoters.

60 he latter of which then binds to CSC-related gene promoters.

61 e evening element (EE) motif found in target gene promoters.

62 pposite methylation profiles on two reporter gene promoters.

63 ence dependency of chromatin interactions at gene promoters.

64 ng polycomb protein activity on the specific gene promoters.

65 pared with genes with fixed or no TRs in the gene promoters.

66 requires the canonical AP-1 sites on target gene promoters.

67 ositioned, hypoacetylated nucleosomes across gene promoters.

68 ancers and leads to altered transcription at gene promoters.

69 the accessibility of RNA polymerases to the gene promoters.

70 ern the organization of epigenetic states at gene promoters.

71 ex to increase H3K4 trimethylation at target gene promoters.

72 ange of histone H1 with HMGB1 at AIRE target gene promoters.

73 says revealed that Msn4 binds beta-oxidation gene promoters.

74 me specifically at the EpCAM, CXCR4 and TFRC gene promoters.

75 fering with the binding of p65 to its target genes promoters.

76 o determine methylation patterns of homeobox gene promoters across gestation.

77 apable of binding to TCF/LEF increased BACE1 gene promoter activity.

78 P2 required CSRP2BP for robust smooth muscle gene promoter activity.

79 ment binding and Nurr1, controlling synapsin gene promoter activity.

80 We demonstrate that IFI16 binds to the lytic gene promoter, acts as a transcriptional repressor, and

81 Thus, loss of RBPJ derepresses target gene promoters, allowing Notch-independent activation by

82 Here, we show that most Ribi gene promoters also contain binding sites for one or mor

83 Gene promoter analyses showed that H19 silenced NOTCH1 b

84 which bound the proximal AP-1 site in the TF gene promoter and activated TF expression.

85 es recruitment of beta-catenin to Wnt target-gene promoter and activates the Wnt signaling pathway by

86 ified DNA base OG to guide BER activity in a gene promoter and impact cellular phenotype ascribes an

87 om a repeat expansion mutation near the FMR1 gene promoter and is the most common form of heritable i

88 identified AP-1 consensus sequence in the TF gene promoter and its original binding components in P2Y

89 nto the locus via a poly(dA:dT) tract in the gene promoter and mediated cohesion before induction.

90 lelic frequencies of GT repeats in the HMOX1 gene promoter and postoperative AKI in 2377 white patien

91 -binding cAMP response element in the GADD34 gene promoter and posttranscriptional stabilization of i

92 ioning of important enzymatic complexes at a gene promoter and represent a technical advancement in t

93 Acetylated TAF9 does not bind to the PU.1 gene promoter and subsequently leads to the disassociati

94 gent CTCF insulator sites flanking the HLA-A gene promoter and the predicted transcriptional regulato

95 using wild-type sequence deriving from Cxcl2 gene promoter and the same sequence bearing a single syn

96 otein-DNA interactions involving 54 phenolic gene promoters and 568 TFs.

97 binds to zinc responsive elements in target gene promoters and activates gene expression.

98 4ac) and lysine 122 (H3K122ac)) marks active gene promoters and also a subset of active enhancers.

99 acetylation (H3K9ac), co-localize on active gene promoters and are associated with active transcript

100 CGIs) are associated with over half of human gene promoters and are characterized by a unique chromat

101 ription-coupled repair at sites of divergent gene promoters and bidirectional enhancer RNA (eRNA) pro

102 n of these structures across the GAL cluster gene promoters and coding regions.

103 ions that are flexible and can be warmed-up (gene promoters and coding sequences), from those that re

104 of the majority of the genomic CpGs outside gene promoters and CpG islands has not been extensively

105 d RNA polymerase II (RNAP II) recruitment to gene promoters and decreased RNAP II C-terminal domain (

106 ults establish a model for Sgf29 function at gene promoters and define a mechanism governing crosstal

107 omatin interactions in the nucleus involving gene promoters and distal regulatory elements are curren

108 ong different single cells, highly expressed gene promoters and enhancers associated with multiple ac

109 ow KLF3 can displace KLF1 from key erythroid gene promoters and enhancers in vivo.

110 as mapping to regulatory elements including gene promoters and enhancers, ultraconserved regions and

111 s, and it co-localizes with HIRA and H3.3 at gene promoters and enhancers.

112 that c-Fos directly binds to multiple viral gene promoters and enhances viral transcription.

113 rough the integration of signals that act at gene promoters and gene-distal enhancers.

114 PLZF and SALL4 preferentially bound gene promoters and introns, respectively.

115 hylation through stage I at ICRs and meiotic gene promoters and is required for the pericentromeric e

116 s PRC2 targeting on the majority of bivalent gene promoters and leads to transcriptional de-repressio

117 isrupted the interaction of PU.1 with target gene promoters and led to downregulation of canonical PU

118 ully independent of interactions with linked gene promoters and occurring in spatial and temporal syn

119 ion landscapes are defined by sharp peaks at gene promoters and other cis-regulatory sequences, but m

120 o DNA methylation, are often associated with gene promoters and play central roles in gene regulation

121 tions in NURF complex occupancy at erythroid gene promoters and reduced chromatin accessibility.

122 d N-Myc protein binding at the ODC1 and E2F2 gene promoters and reduced neuroblastoma cell proliferat

123 acterized transcription factor that can bind gene promoters and regulate target gene transcription in

124 In endothelial cells, ETS1 binds transcribed gene promoters and stimulates their expression by broadl

125 osophila, we find that TAF1 is present at RP gene promoters and that its interaction might also be di

126 at histone Kbhb is a mark enriched in active gene promoters and that the increased H3K9bhb levels tha

127 ontribute to structural interactions between gene promoters and their enhancer elements.

128 d their binding sites into those proximal to gene promoters and those in distal regions, and develope

129 BTD1 allows TIP60 to associate with specific gene promoters and to promote the repair of DNA double-s

130 Gene promoters and UTRs harbor more OG-enriched sites th

131 MEP50 expression, association with the hINV gene promoter, and H3R8me2s and H4R2me2s formation.

132 ctivates transcription of the p21(Waf1/Cip1) gene promoter, and overexpression of Foxp1 in neurons re

133 arly decreased MLL1, H3K4me3 at inflammatory gene promoters, and inflammatory cytokines compared with

134 an increase in MLL1, H3K4me3 at inflammatory gene promoters, and inflammatory cytokines.

135 ) are generated through the use of different genes, promoters, and alternative splicing, but the func

136 nsgenic for Cre under the control of the lck gene promoter are used to study the role of loxP-targete

137 r cellular context, our results suggest that gene promoters are distinguished from distal enhancers b

138 In addition, gene promoters are largely divergent and initiate transc

139 In patients, tumour suppressor gene promoters are markedly more methylated in hypoxic t

140 kingly, we found that liver-specific lincRNA gene promoters are more highly species conserved and hav

141 ble and potentially functional sites such as gene promoters are mostly stable.

142 romeric repeats, transposons and a number of gene promoters, are capable of reestablishing DNA methyl

143 We here describe the PRKD1 gene promoter as a target for oncogenic KRas signaling.

144 ive nucleosome repositioning at thousands of gene promoters as genes are activated and repressed.

145 n conclusion, longer GT repeats in the HMOX1 gene promoter associate with increased risk of AKI after

146 merase II were found to occupy the cyclin B1 gene promoter at reduced levels during infection.

147 ption activation domain (TAD) to an intended gene promoter at the endogenous genomic locus through a

148 rmation corresponds to XdhR binding the xdhR gene promoter at two adjacent sites; at higher protein c

149 osphorylated RNA polymerase II (RNAP) on the gene promoter, body, and terminus of VZV genes 9, 51, an

150 es at LCR HS2 and the adult betamajor-globin gene promoter but did not affect expression of the betam

151 mammalian brain, is altered within the Htr2a gene promoter by early life stress and biological sex, a

152 on co-activator complex SAGA is recruited to gene promoters by sequence-specific transcriptional acti

153 rs during genic transcription and to repress gene promoters by transcriptional interference.

154 Indeed, Zfp609 and Nipbl co-localize at gene promoters containing paused RNA polymerase 2, and I

155 ecruitment of tail module subunits to active gene promoters continues genome-wide when Mediator integ

156 unoprecipitation (ChIP) analysis of the CCN1 gene promoter demonstrated that S1P increases coactivato

157 The level of marks over specific gene promoters did not correlate to mRNA level changes i

158 tokine levels, and IL-4, INF-gamma and Foxp3 gene promoter DNA methylation status, and their correlat

159 ion (RGM) that relies on a minimal imprinted gene promoter driving a fluorescent protein.

160 tion complexes to the adult betamajor-globin gene promoter during erythroid cell differentiation.

161 id demethylation of the insulin and glucagon gene promoters during differentiation of Neurogenin3(+)

162 n deficiency affected histone acetylation at gene promoters during this process.

163 Methylation of developmental gene promoters during tumorigenesis may therefore reflec

164 to contribute to this signature in selected gene promoters (e.g. MYC).

165 ethylation at CpG dinucleotides in the c-Fos gene promoter, effects reversed by MET treatment.

166 on of open reading frames, identification of gene promoter elements, intron/exon splicing sites, and

167 histone variant H2A.Z is a universal mark of gene promoters, enhancers, and regulatory elements in eu

168 nded to Abeta insult by binding to the Trib3 gene promoter, enhancing its expression.

169 tion elongation factor b (P-TEFb), to target gene promoters, enhancing transcriptional elongation.

170 In contrast, elements distal to gene promoters exhibited more variable methylation betwe

171 Moreover, gene silencing and gene promoter experiments indicated that IRF6 acts downs

172 These two marks frequently co-occupy gene promoters, forming bivalent domains.

173 In an unbiased search of core clock gene promoters from 12 species of Drosophila, we discove

174 e modifications and factor binding at lncRNA gene promoters from ChIP-seq to explore lncRNA gene stru

175 optera frugiperda Sf9 cells can activate AMP gene promoters from M. sexta and D. melanogaster.

176 However, gene promoters generate more promoter activity than dist

177 olving targeted regions of interest, such as gene promoters, globally and at high resolution.

178 Using RT-quantitative PCR analysis and gene promoter::GUS fusions, we first showed that AtPME3

179 At select gene promoters, H3K9ac loss or SEC depletion reduces gen

180 hCYP11B2 gene promoter has 3 single-nucleotide polymorphisms in l

181 For example, some gene promoters have been proposed to have dual functions

182 ncers often initiate transcription, and some gene promoters have the potential to enhance transcripti

183 e transcriptome and histone modifications at gene promoters; however, the enhancer repertoire and ass

184 pression of ecRNA species is associated with gene promoter hypomethylation, is altered by neuronal ac

185 scovered role of the BCL2 (B-cell lymphoma 2 gene) promoter i-motif DNA in modulation of gene express

186 nterestingly, CsMYBF1 could activate the CHS gene promoter in citrus, but not in tomato.

187 methyltransferase Dam, tethered to the Gad1 gene promoter in mouse prefrontal cortex neurons, result

188 ecruitment of beta-catenin to the Wnt target-gene promoter in the nucleus, but its mechanisms are lar

189 tion/demethylation are recruited to bivalent gene promoters in a cell cycle-dependent fashion.

190 DNA methylation at gene promoters in a CG context is associated with transc

191 P2BP synergistically activated smooth muscle gene promoters in an SRF-dependent manner.

192 lysis genes, ATFS-1 bound directly to OXPHOS gene promoters in both the nuclear and mitochondrial gen

193 Linking such regulatory regions to gene promoters in disease-relevant cell contexts facilit

194 cilitate the binding of the GR to its target gene promoters in fat depots.

195 K9/14 hyperacetylation in approximately 5000 gene promoters in glomerular mesangial cells, including

196 f chromosomal interactions involving 22,000 gene promoters in human pluripotent and lineage-committe

197 s between distal DNA regulatory elements and gene promoters in multiple tissue contexts.

198 the presence of HDAC11 at the Eomes and Tbet gene promoters in resting T cells, where it rapidly disa

199 the repressive histone variant H2A.Z at INK4 gene promoters in senescent cells.

200 eveal constitutive binding of CREB to target gene promoters in the absence of neuronal activity, wher

201 lled transcriptional enhancers that activate gene promoters in the right cells, at the right time.

202 2 and 4) bind the stress-response element in gene promoters in the yeast Saccharomyces cerevisiae How

203 f TET activity increases hypermethylation at gene promoters in vitro.

204 rthermore, there were changes at BDNF exon I gene promoter, in concert with overall BDNF levels in th

205 Classically activated M1-Mvarphi gene promoters, including Cfb, Serping1, and Tnfsf15, we

206 , whereas alternatively activated M2-Mvarphi gene promoters, including Nrp1, Cxcr4, Plxnd1, Arg1, Cdk

207 ated CpG sites within the proximal region of gene promoters, including some genes that have previousl

208 many of the induced ergosterol and anaerobic gene promoters, increases its association with several r

209 increases Ser5P-RNAPII at LEF-1 sites and ME gene promoters, indicating that elongation remains limit

210 the telomerase reverse transcriptase (TERT) gene promoter is a common ALV integration target.

211 rovide experimental evidence that this grape gene promoter is activated by the pathogen in a SA-indep

212 Earlier studies suggested that the insulin gene promoter is uniquely unmethylated in insulin-expres

213 Nucleosome repositioning at gene promoters is a fundamental aspect of the regulation

214 NA to yield 8-oxo-7,8-dihydroguanine (OG) in gene promoters is a signaling agent for gene activation.

215 ylation at Myc-responsive elements of target gene promoters is a strict prerequisite for Myc-induced

216 The occupancy of Stowaway elements in gene promoters is concomitant with an increase in recomb

217 PerR binding to gene promoters is controlled by the presence of iron in

218 plicated in transcription initiation, to TFI gene promoters is increased upon depletion of TBP family

219 rprisingly, the greater promoter activity of gene promoters is not due to conventional core promoter

220 hough the transcriptional role of SMARCA4 at gene promoters is well-studied, less is known about its

221 wn that hypermethylation of tumor suppressor genes promoters is a common feature of cancer cells.

222 H3K4me1 histone modification of the fibrotic gene promoter, leading to a decrease in the fibrotic gen

223 DNA methylation in gene promoters leads to gene silencing and is the therap

224 ulates TrkA expression by acting at the trkA gene promoter level.

225 T cells type c-1, associated with increased gene promoter levels of the transcriptional repression m

226 igenetic heterogeneity at p14(ARF) and BRCA1 gene-promoter loci in liquid biopsies obtained from pati

227 on of p65 recruitment to NF-kappaB-dependent gene promoters, may underlie CS insensitivity of severe

228 sitively correlated with IFN-gamma and Foxp3 gene promoter methylation levels (P<.0011) (P<.0165).

229 associated with increased P53 pro-apoptotic gene promoter occupancy and target gene expression.

230 the telomerase reverse transcriptase (TERT) gene promoter occur at high frequency in multiple cancer

231 Binding of Nup153 to gene promoters or transcriptional end sites correlates w

232 Antisense transcripts originate either at gene promoters or within the gene body, and they show di

233 t prevent effector binding to susceptibility gene promoters, or that allow effector activation of res

234 interactions between regulatory elements and gene promoters play key roles in transcriptional regulat

235 nd that the Hox proteins AbdA and Ubx target gene promoters previously bound by the transcription pau

236 eterogeneity at the Helicobacter pylori cagA gene promoter region has been linked to variation in Cag

237 DNA methylation at a gene promoter region has the potential to regulate gene

238 g) transcriptional start site and within the gene promoter region of Egr-1 (early growth response pro

239 ysine 4 di-methylation (H3K4me2), to the AHR gene promoter region, resulting in repression of AHR exp

240 the PacC/Rim101 consensus binding-motifs in gene promoter regions and by the promoter DNA-binding as

241 sites in LCR HS2 or in the adult beta-globin gene promoter regions exhibit low fractional occupancy,

242 howed that pCREB enrichment on the C/EBPbeta gene promoter regions in rats with gp120 was higher than

243 We show that within gene promoter regions of mouse hepatocytes the epimutati

244 anism by which microRNAs could interact with gene promoter regions to modify gene transcription.

245 e enhancer regions) and H3K4me3 (enriched in gene promoter regions) show the same distributions acros

246 , as well as its binding to SMAD3 and target gene promoter regions, was evaluated in the nucleus accu

247 and translocates to lysosomal and autophagy gene promoter regions, where ACSS2 incorporates acetate

248 tone mark peaks in relevant tissue types and gene promoter regions.

249 diversity of epialleles analysed at specific gene promoter regions.

250 ularly for detecting weak binding signals at gene promoter regions.

251 chromatin and are found associated with Hox gene promoter regions.

252 ntioxidant response elements (AREs) in their gene promoter regions.

253 DNA binding sites include approximately 1700 gene promoter regions.

254 oughout genomes, and are especially found in gene promoter regions.

255 with TFIID to facilitate assembly on target gene promoters remains elusive.

256 Repression of telomerase gene promoter requires human-specific genomic context an

257 inding to SBE DNA in TGF-beta-responsive SMC gene promoters, resulting in suppression of SMC marker g

258 ening for Myb-binding sites in the candidate gene promoter sequences revealed that 141 of the 152 co-

259 ssess global histone acetylation levels, and gene promoter-specific interactions were measured by chr

260 Newly Diagnosed Glioblastoma and Methylated Gene Promoter Status; NCT00689221), CORE (Cilengitide, T

261 ewly Diagnosed Glioblastoma and Unmethylated Gene Promoter Status; NCT00813943), and Radiation Therap

262 t of the repressive DREAM complex to the A3B gene promoter, such that loss of p53 through mutation, o

263 ping data show that highly active Brdt-bound gene promoters systematically harbor competing histone a

264 ptionally active histone modifications at M2 gene promoters than did macrophages from male mice.

265 This can be achieved by using a gene promoter that is only active in embryos to drive ex

266 l for restricting the chromatin signature of gene promoters that otherwise may license or promote cry

267 We defined 94 gene promoters that were hypomethylated significantly by

268 duction, including enhancer-like activity of gene promoters, the process of transcription, and the sp

269 g of MrpJ to two virulence-associated target gene promoters, the promoters of the flagellar master re

270 ER to cis-regulatory elements within target gene promoters, thereby inhibiting estrogen-induced gene

271 TNFalpha regulates the egfl7 gene promoter through regions located between -7585 and

272 tion is regulated through binding factors to gene promoters to activate or repress expression, howeve

273 techniques using lineage-specific endogenous gene promoters to confine transgene expression to indivi

274 sly identified transcriptional regulator, at gene promoters to control transcription of its target ge

275 ltransferase (HAT) complex to ERalpha target gene promoters to deposit histone H4K16 acetylation prom

276 how a consistent contribution of neighboring gene promoters to gene expression and identify unmarked

277 lizes in nucleoli and binds to ribosomal RNA gene promoters to help repress rRNA genes.

278 es showed that RB1-E2F complexes bind to MPT gene promoters to regulate transcription and control MPT

279 nt of understudied intergenic CpGs distal to gene promoters to reveal the full extent of inter-indivi

280 rovide the first genome-wide catalog linking gene promoters to their long-range interacting elements

281 We found that Cbx3 binds to gene promoters upon differentiation of murine embryonic

282 activation domain of FoxM1 to the cyclin B1 gene promoter via clustered regularly interspaced short

283 activation domain of FoxM1 to the cyclin B1 gene promoter via CRISPR-catalytically inactive Cas9 (dC

284 In epiblast cells, TET1 demethylates gene promoters via hydroxymethylation and maintains telo

285 subset of genes and was recruited to active gene promoters via MeCP2.

286 rned by the adipocyte-restricted adiponectin gene promoter was adoptively transferred to wild-type re

287 transcriptional start site of IL-6 and CXCL8 gene promoters was performed.

288 By swapping gene promoters, we show that Arabidopsis KAI2 and D14 pr

289 SASEs in selected cancer gene promoters were associated with over-expression, and

290 acetylation and its recruitment onto target gene promoters were increased in liver of EtOH-fed mice.

291 erepressed, and the H3K27me3 levels in these gene promoters were significantly reduced on Ezh2 deleti

292 e binding of NF-Y proteins to these modules' gene promoters were verified using ENCODE ChIP-Seq data.

293 butyrylation of histone H4 lysine 5 and 8 at gene promoters where acetylation guides the binding of B

294 elieves its repression of the methylated Lhb gene promoter, which is then hydroxymethylated and activ

295 -2 binds and transcriptionally regulates EDC gene promoters, which are co-occupied by the transcripti

296 ted with a subset of essential developmental gene promoters, which are located within CGIs and are pr

297 is reveals predominant R-loop formation near gene promoters with strong G/C skew and propensity to fo

298 itation followed by sequencing to screen for gene promoters with the activating histone 4 acetylation

299 associated with hypermethylation of TEs and gene promoters, with influence observed for methylation

300 of transcription from E-box-containing clock gene promoters within key pacemaker neurons.