ライフサイエンスコーパス: gene regulation

1 age, and as a result, they have relevance in gene regulation.

2 mportance of metastable states for RNA-based gene regulation.

3 s, which suggested possible contributions to gene regulation.

4 acts as a brake on chromatin remodeling and gene regulation.

5 ic mutations and its epigenetic potential in gene regulation.

6 ssociated gene expression changes and unique gene regulation.

7 role of higher-order chromatin structure in gene regulation.

8 portant sequence determinants for long-range gene regulation.

9 noncoding RNAs that play a critical role in gene regulation.

10 molecular mechanisms underpinning endogenous gene regulation.

11 en nuclear organization and local changes in gene regulation.

12 rtant yet relatively under-explored facet of gene regulation.

13 esized H3.3 to these regulatory elements for gene regulation.

14 amic epigenomic correlate of allele-specific gene regulation.

15 may provide an important additional mode of gene regulation.

16 onal mechanisms associated with inflammasome gene regulation.

17 into a nuclear domain of coordinated histone gene regulation.

18 inity CUX1 binding sites, features of analog gene regulation.

19 ding to a better understanding of epigenetic gene regulation.

20 r conserved histones retain central roles in gene regulation.

21 nt biological challenge necessary to explain gene regulation.

22 n dynamics, transcription factor binding and gene regulation.

23 plants to sense and respond to light through gene regulation.

24 itating a deeper understanding of endogenous gene regulation.

25 romatin structure and its potential roles in gene regulation.

26 pe of rapamycin-induced post-transcriptional gene regulation.

27 ing a novel means for sensitive detection of gene regulation.

28 hat has distinct functional consequences for gene regulation.

29 that Pol II pausing plays a dominant role in gene regulation.

30 opposite effects on cellular homeostasis and gene regulation.

31 lays broader role(s) in post-transcriptional gene regulation.

32 ases (KMTs) and demethylases (KDMs) underpin gene regulation.

33 f the relationship between the epigenome and gene regulation.

34 erodimers in EBNA3 recruitment during target-gene regulation.

35 tin architecture and have important roles in gene regulation.

36 or cell types due to highly context-specific gene regulation.

37 ons of neuronal properties, which depends on gene regulation.

38 ocess of genome evolution and play a role in gene regulation.

39 ed with both a complex trait and measures of gene regulation.

40 genomes into spatial domains is critical for gene regulation.

41 of stable remission and explain autoantigen gene regulation.

42 patiotemporal features of viral and cellular gene regulation.

43 critical for understanding the principles of gene regulation.

44 terest (or "bait") that can be important for gene regulation.

45 and is implicated in cellular responses and gene regulation.

46 ould be used to identify regions involved in gene regulation.

47 shed light on important aspects of mammalian gene regulation.

48 for normal PcG chromatin domain function in gene regulation.

49 ing complex is a critical step in eukaryotic gene regulation.

50 actor highly implicated in VEGF-A and VEGF-C gene regulation.

51 expression, suggesting functional impact on gene regulation.

52 ription complexes capable of DNA binding and gene regulation.

53 me maps that are important for understanding gene regulation.

54 re important players in post-transcriptional gene regulation.

55 e useful tools in biosensors and conditional gene regulation.

56 understanding of how chromatin states affect gene regulation.

57 that couple the peptide-induced allostery to gene regulation.

58 ting potential to transform our knowledge of gene regulation.

59 on-redundant functions in plant immunity and gene regulation.

60 us to understand the underlying mechanism of gene regulation.

61 uggesting interplay between these factors in gene regulation.

62 independent pathways of post-transcriptional gene regulation.

63 ed the ribosome to more selective control of gene regulation.

64 ar compartments, and their proposed roles in gene regulation.

65 obiological processes involved in peripheral gene regulation.

66 al to improving our understanding of in vivo gene regulation.

67 onfirmed clusters are the functional unit of gene regulation.

68 fic instances of disease-relevant changes to gene regulation.

69 onequilibrium dynamics of the chromosome and gene regulation.

70 itional links between tRNA modifications and gene regulation.

71 els, suggesting that copper affects tryptase gene regulation.

72 n increasingly used to dissect the nature of gene regulation.

73 rse normal functions in genome structure and gene regulation.

74 es plays a role in the specificity of target gene regulation.

75 nabled robust analysis at multiple layers of gene regulation.

76 ain implicated in epigenetic recognition and gene regulation, a phenomenon that has remained unexplor

77 to study the impact of genetic variation on gene regulation across different cell types and as model

78 indicating sharing of downstream cis-/trans-gene regulation across tissues and CMDs.

79 Meanwhile, the modes of the gene regulations (activation and repression) come from p

80 ial insects are emerging models to study how gene regulation affects behavior because their colonies

81 robustness by examining whether conditional gene regulation altered heterogeneity in gene expression

82 into the multiscale mechanisms that connect gene regulation and 3D epithelial morphogenesis.

83 DACs) are important modulators of epigenetic gene regulation and additionally control the activity of

84 vidence for a new mechanism of Zap1-mediated gene regulation and another way that this activator prot

85 ne, which usually plays an essential role in gene regulation and biological processes.

86 MicroRNAs (miRNAs) play important roles in gene regulation and cancer development.

87 genomic methylation patterns ensures proper gene regulation and cell behaviour, impacting normal dev

88 y link the outside environment to epigenetic gene regulation and cellular function, and their actions

89 ng loci and elucidate their diverse roles in gene regulation and cellular function.

90 tone modifications play an essential role in gene regulation and cellular specification required for

91 ast year, we have improved our resources for gene regulation and comparative genomics, and added CRIS

92 causal relationships between differences in gene regulation and corresponding differences in phenoty

93 n (ASE) is a fundamental problem in studying gene regulation and diploid transcriptome profiles, with

94 to provide high diversity and complexity of gene regulation and expression, highlighting the importa

95 Understanding gene regulation and function requires a genome-wide meth

96 dentity as well as noncoding information for gene regulation and genome maintenance.

97 ide novel insights into the role of ModH5 in gene regulation and how it mediates epigenetic regulatio

98 igher-order protein assemblies implicated in gene regulation and human disease.

99 nstrated the critical role of TEs in primate gene regulation and illustrated potential mechanisms und

100 s the impact of these novel findings to Pdx1 gene regulation and islet beta-cell maturation postnatal

101 ation for systems-level studies of notochord gene regulation and morphogenesis.

102 finger (ZF) proteins have prominent roles in gene regulation and often execute multiple regulatory fu

103 poral chromatin organization and its role in gene regulation and other cellular processes.

104 ting domains (TADs), and loops to facilitate gene regulation and other chromosomal functions.

105 ion, and investigate how these contribute to gene regulation and other genome functions.

106 which marks actually have causative roles in gene regulation and other processes.

107 HV with potentially important roles in viral gene regulation and pathogenesis.

108 or both HI and PKD and provide insights into gene regulation and PMM2 pleiotropy.

109 tervention, as well as broader principles of gene regulation and signal-dependent TFs.

110 Stromal cell (macrophage) gene regulation and signalling represent valid targets f

111 ighlights the importance of miRNA editing in gene regulation and suggests its potential as a biomarke

112 ) is a genomic locus that is responsible for gene regulation and that contains multiple transcription

113 tion is an important epigenetic mechanism in gene regulation and the detection of differentially meth

114 on, enabling a mechanistic interpretation of gene regulation and the genetic basis of disease.

115 t results in heritable epigenetic changes of gene regulation and trans-homologue interactions.

116 gulatory variants is essential to understand gene regulation and ultimately disease pathophysiology.

117 tigen-R (HuR), controls post-transcriptional gene regulation and undergoes stress-activated caspase-3

118 such as protein phosphorylation, signaling, gene regulation, and cell metabolism.

119 s abrogated PBRM1 tumor suppressor function, gene regulation, and chromatin affinity with the degree

120 al a connection between cellular metabolism, gene regulation, and neural plasticity and establish a l

121 o enhancement of transcription, translation, gene regulation, and other aspects of cellular metabolis

122 duces a hierarchical model for developmental gene regulation, and reveals a major role for noncoding

123 inct roles for H2A.Z and SWR1c components in gene regulation, and suggest a potential role for PIE1 i

124 Conditional gene regulation approaches are required to study the fun

125 s controlled and the function of L1s in host gene regulation are not completely understood.

126 s comparisons of genomes, transcriptomes and gene regulation are now feasible at unprecedented resolu

127 geroid disease progression, and suggest TP63 gene regulation as a potential therapeutic target.

128 cer modeling and implicate enhancer-mediated gene regulation as a principal tumor-suppressor function

129 architecture of glycemic traits and suggest gene regulation as a target to advance precision medicin

130 Finally, we review unresolved questions in gene regulation as it pertains to speciation and point t

131 Such undulations might affect gene regulation as well as contribute to the anomalously

132 TE-eQTL are involved in population-specific gene regulation as well as transcriptional network modif

133 ationship between nucleosome positioning and gene regulation, as cells transition between development

134 elective advantage as it enables coordinated gene regulation at the chromatin level.

135 w that a general thermodynamic framework for gene regulation, based on a biophysical understanding of

136 to GRFs as new multifaceted players in Ribi gene regulation both during exponential growth and under

137 ulatory networks is central to understanding gene regulation, but remains an open challenge.

138 yl-CoA) is linked to histone acetylation and gene regulation, but the precise mechanisms of this proc

139 order chromosome structure play key roles in gene regulation, but their functional interplay in contr

140 s) are known to mediate post-transcriptional gene regulation, but their role in postnatal brain devel

141 s to selectively influence DNA occupancy and gene regulation by a transcription factor.

142 ay be a previously unexplored aspect of KSHV gene regulation by confiscation of a limited supply of R

143 lementary mechanisms by which XPC influences gene regulation by coordinating efficient TDG-mediated D

144 Herein we aimed to investigate AMP gene regulation by deciphering specific characteristics

145 Polyamines involve in gene regulation by interacting with and modulating the f

146 rt the biological function of mCpG-dependent gene regulation by KLF4 in glioblastoma cells.

147 n remodeling machines play a central role in gene regulation by manipulating chromatin structure.

148 f DNA binding specificity for organ-specific gene regulation by modulating promoter activity through

149 Argonaute proteins mediate gene regulation by small RNAs and thereby contribute to

150 results reveal a new layer of complexity in gene regulation by super-enhancers and broad H3K4me3 dom

151 ne gene supporting existing models of direct gene regulation by TE-derived siRNAs.

152 study demonstrates that posttranscriptional gene regulation by TTP schedules the termination of the

153 This gene regulation can be mimicked by the administration of

154 Aberrant gene regulation causes suture dysmorphogenesis resulting

155 leoporins are linked with cell-type-specific gene regulation, coupling physical changes in nuclear st

156 re of the underlying genetic architecture of gene regulation.Covariance of gene expression pairs is d

157 ological processes such as gene interaction, gene regulation, DNA replication and genome methylation.

158 important role in cellular processes such as gene regulation, DNA replication and genome methylation.

159 ged in recent years are discussed, including gene regulation, drug delivery and materials design.

160 s for cotranscriptional/post-transcriptional gene regulation during development.

161 dependent APA provides an important layer of gene regulation during learning and memory.

162 bookmarking play pivotal roles in stringent gene regulation during lineage commitment and maintenanc

163 ply this method to the study of dynamic tRNA gene regulation during macrophage development and furthe

164 onship between linear and 3D organization of gene regulation during myogenesis.

165 Plant small RNAs play important roles in gene regulation during pathogen infection.

166 ith their known effects on FLOWERING LOCUS C gene regulation during the transition to flowering.

167 g also makes it possible to assess antisense gene regulation efficiency of these brush-DNA conjugates

168 However, the mechanisms underpinning the gene regulation essential for brain regeneration are lar

169 ar interactions of ncRNAs are at the core of gene regulation events, and identifying the full map of

170 over, Tregs with exaggerated miR-27-mediated gene regulation exhibited diminished homeostasis and sup

171 for local causal pathways reconstruction of gene regulation for 5 transcription factors in S. cerevi

172 genesis involves orchestration of sequential gene regulation for somatic differentiation in pre-meiot

173 the TADs for a genome is useful for studying gene regulation, genomic interaction, and genome functio

174 Single-cell trajectories can unveil how gene regulation governs cell fate decisions.

175 In-depth knowledge of miRNA-based gene regulation has made it possible to unravel pathomec

176 The study of gene regulation has rapidly advanced by leveraging next-

177 g in promoter regions, and their relation to gene regulation, have been the topic of much research ov

178 ormation is an important feature of metazoan gene regulation; however, enhancer-promoter contact remo

179 controlled transcriptional and translational gene regulation implemented by a wide variety of riboswi

180 lation score that quantifies the strength of gene regulation imposed by each class of regulatory elem

181 Previously, we demonstrated how conditional gene regulation in a fluctuating environment drives dilu

182 ead in bacteria and mediates light-dependent gene regulation in a photoprotective cellular response.

183 sults demonstrate that the identification of gene regulation in a specific population of DRG neurons

184 oration of functional noncoding DNA to study gene regulation in a variety of plant species, including

185 which has implications for hormone-dependent gene regulation in breast cancers.

186 hese maps have been widely used for studying gene regulation in cell type-specific contexts and predi

187 s, bacteriophage lambda, is paradigmatic for gene regulation in cell-fate development, yet insight ab

188 functional, SLI-associated variant affecting gene regulation in cells and post-mortem human brain.

189 modification provides an additional layer of gene regulation in cells.

190 modulation of the CTD code that may augment gene regulation in developmentally complex organisms.

191 s (lncRNA) has provided a new perspective on gene regulation in diverse biological contexts.

192 We propose that Hoxd gene regulation in embryonic MBs evolved by hijacking a

193 enomic regions is one of the key features of gene regulation in eukaryotes.

194 ssential elements of chromatin structure and gene regulation in eukaryotes.

195 nt developmental and infection processes and gene regulation in F. graminearum.

196 Contrastingly, gene regulation in FMDV carriers suggested inhibition of

197 Our data suggest new mechanisms of pilus gene regulation in GAS and that the invasiveness associa

198 that the invasiveness associated with pilus gene regulation in GAS differs from the enhanced invasiv

199 ore accelerate researches in transcriptional gene regulation in higher eukaryotes.

200 ritical mechanism for proteome expansion and gene regulation in higher eukaryotes.

201 d overview of the principal layers of global gene regulation in human pluripotent stem cells.

202 nd PRC2 play a central role in developmental gene regulation in multicellular organisms.

203 d MIAT overexpression and their reproducible gene regulation in ovarian cancer EMT.

204 ortant role for RppH in post-transcriptional gene regulation in pathogenic Epsilonproteobacteria and

205 mechanisms have been proposed for mediating gene regulation in response to p53, recent advances in o

206 -relevant tissues, implicating CTCF-mediated gene regulation in risk of neurodegeneration more genera

207 verall understanding of post-transcriptional gene regulation in roots of P. notoginseng but also coul

208 of DNA methylation and its relationship with gene regulation in seed development.

209 rinciples towards a better representation of gene regulation in silico, with promising applications i

210 nhanced understanding of dynamic behavior of gene regulation in the biological system.

211 tex expression, suggesting a major impact of gene regulation in the brain on genome shaping along the

212 tion factors have been identified for proper gene regulation in the chambers, the complete transcript

213 and the mechanisms of MEF2-mediated regional gene regulation in the heart, we took advantage of MEF2A

214 iac hypertrophy and define a new paradigm of gene regulation in the heart, where controlled changes i

215 olbox for the functional characterization of gene regulation in the highly repetitive maize genome.

216 exity of transcription factor expression and gene regulation in the MOE.

217 Recent developments suggest that gene regulation in the parasite is largely controlled by

218 understanding of the mechanisms controlling gene regulation in the parasite, including nucleosome la

219 the loss of miRNA processing and subsequent gene regulation in the RPE due to DICER1 deficiency also

220 We determined CUX1 DNA-binding and target gene regulation in the wildtype and haploinsufficient st

221 sorghum gene annotations and aid in studying gene regulation in this important bioenergy crop.

222 viding a basis for a better understanding of gene regulation in this important crop plant.

223 erved, novel genomic signatures of potential gene regulation in Trichodesmium.

224 ed macrophages, we identify a unique mode of gene regulation in which the parasite Leishmania donovan

225 tional changes associated with developmental gene regulation in WT.

226 expression profiles can help to decipher TF-gene regulations in a variety of contexts; however, the

227 ing GAS fitness mutations in vivo, virulence gene regulation, in vivo gene expression, and virulence.

228 ion, we observe changes in proximal-anterior gene regulation, including a reduction in the expression

229 y important roles in genome architecture and gene regulation, including robustness in the development

230 n evolution entailed multiple innovations in gene regulation, including the emergence of genomic impr

231 and highlights a novel method of chondrocyte gene regulation involving a lncRNA.

232 ated nuclei provide access to early steps in gene regulation involving chromatin as well as transcrip

233 The importance of RNA protein-coding gene regulation is by now well appreciated.

234 Post-transcriptional gene regulation is critical for adequate cellular growth

235 Fundamentally, gene regulation is linked to the flow of information.

236 ell type-specific, whereas ubiquitous target gene regulation is more likely to result from binding to

237 Precise spatiotemporal gene regulation is paramount for the establishment and m

238 fferent roles in chromosome architecture and gene regulation, is specified by where on the chromosome

239 Despite the combinatorial complexity of gene regulation, its quantitative behavior has been typi

240 anscription factors have opposing effects on gene regulation, like P53 tumor suppressor and cMYC prot

241 tworks (TRNs), with three different types of gene regulation logics.

242 the nucleosome and vice versa, suggesting a gene regulation mechanism where cytosine modifications c

243 The gene regulation mechanisms necessary for the development

244 The gene regulation mechanisms they instigate are largely me

245 by interactions between DNA methylation and gene regulation mechanisms.

246 ylation is a novel mechanism of gamma-globin gene regulation mediated by modulating the assembly of t

247 rinciples of spatial genome organization and gene regulation mediated by specific protein factors.

248 n essential step toward our understanding of gene regulation networks.

249 e findings reveal novel features of human EC gene regulation not present in their murine counterparts

250 s involved primarily in post-transcriptional gene regulation of RNAs.

251 ay an important role in post-transcriptional gene regulation of several physiological and pathologica

252 Identifying interspecies changes in gene regulation, one of the two primary sources of pheno

253 ffect the efficiency of EPC, suggesting that gene regulation over a distance could be modulated by ch

254 repetitive elements may play a role in host gene regulation, particularly through the donation of al

255 approach to assess the activity of specific gene regulation pathways involved in inflammation, antiv

256 RNA interference (RNAi)-based gene regulation platforms have shown promise as a novel

257 resource for the systematic investigation of gene regulation processes, a lack of standardized curati

258 UG codons plays an important role in various gene regulation programs.

259 This model of gene regulation raises the intriguing notion that transc

260 mplex traits are thought to act by affecting gene regulation rather than directly altering the protei

261 Epigenetic gene regulation relies upon multifactorial processes tha

262 the causal link between epigenetic marks and gene regulation remains a central question in chromatin

263 d the molecular mechanism of lncRNA-mediated gene regulation remains largely unexplored, particularly

264 mpact of ERV propagation on the evolution of gene regulation remains poorly understood.

265 ut their contribution to traits, disease and gene regulation remains unclear.

266 e whole-genome scale, many complicated multi-gene regulations require more advanced detection methods

267 However, understanding gene-regulation require knowledge of detailed spatial st

268 anding the link between epigenetic marks and gene regulation requires the development of new tools to

269 a model system for studies of translational gene regulation, RNA-protein interactions, and RNA virus

270 Gene regulation shapes the evolution of phenotypic diver

271 Bioinformatic and gene regulation studies suggest that two proteins might

272 the limb is also becoming a model system for gene regulation studies.

273 etic factors had a stronger effect on immune gene regulation than age and sex, yet they affected a sm

274 ing the coordination of post-transcriptional gene regulation that allows organisms to respond to inte

275 summary, 3'-UTRs seem to be major players in gene regulation that enable local functions, compartment

276 nd conditional property of microRNA-mediated gene regulation that remains under-investigated.

277 mic program generates a lifespan calendar of gene regulation that times age-dependent molecular organ

278 ional link between AID and TET in epigenetic gene regulation, the role of AID loss in hematopoiesis a

279 Despite being a nexus of eukaryotic gene regulation, the structure of the CTD and the struct

280 e formation of another domain of coordinated gene regulation: the dosage-compensated male X chromosom

281 s are characterized by marked alterations in gene regulation through differential enhancer utilizatio

282 Our findings uncover a strategy of KSHV gene regulation through focal assembly of KSHV episomes

283 Long noncoding RNAs (lncRNAs) affect gene regulation through structural and regulatory intera

284 Here, we analyse elt-2 gene regulation through transgenic reporter assays, ELT-

285 programs such as meiosis depend on extensive gene regulation to mediate cellular morphogenesis.

286 sical model of Cas9-based genome editing and gene regulation to predict how changing guide RNA sequen

287 for future computational modeling of E. coli gene regulation, transcription, and translation.

288 ave only a minor, largely modulatory role in gene regulation under diverse trophic states.

289 gical conditions is useful for understanding gene regulation underlying complex phenotypes.

290 effects suggests a critical role of cryptic gene regulation underlying many disease traits.

291 a Rho-independent transcription terminator, gene regulation was no longer PNPase-dependent.

292 stinct temporal peaks demonstrating multiple gene regulation waves in LTAM.

293 large set of noncoding RNA modifications in gene regulation, we carried out ribosome profiling in bu

294 relation between chromatin organization and gene regulation, we introduce a computational procedure

295 , radical rearrangement, and light-activated gene regulation, while also holding promise as light-act

296 is a key epigenetic modification involved in gene regulation whose contribution to disease susceptibi

297 Insights into its gene regulation will provide clues in designing anti-CMV

298 ssection allowed elucidation of differential gene regulation within distinct anatomic compartments cr

299 romatin organization is important for proper gene regulation, yet how the genome is remodeled in resp

300 Chromatin looping is key to gene regulation, yet no broadly applicable methods to se