ライフサイエンスコーパス: gene silencing

1 RNA transcripts to induce co-transcriptional gene silencing.

2 gineered and scalable platform for regulated gene silencing.

3 acetylation in heterochromatin spreading and gene silencing.

4 the observed cooperativity in miRNA-mediated gene silencing.

5 theless, HDAC activity contributed to stable gene silencing.

6 sequent increase in dendritic miRNA-mediated gene silencing.

7 ance of DNA methylation, and for therapeutic gene silencing.

8 e, inhibition of polyadenylation may lead to gene silencing.

9 1 and 2) leading to chromatin compaction and gene silencing.

10 clear periphery and heterochromatin-mediated gene silencing.

11 e an efficient siRNA vector with significant gene silencing.

12 ciated factor X), which promotes RNA-induced gene silencing.

13 etically inherited in cis, leading to stable gene silencing.

14 nd precise siRNA delivery for high efficient gene silencing.

15 RNAi triggers, which together result in HBV gene silencing.

16 lementary loci, resulting in transcriptional gene silencing.

17 ted in the Drosophila heart using RNAi-based gene silencing.

18 sponsible for histone H2A ubiquitination and gene silencing.

19 Methylated cytosines are associated with gene silencing.

20 es progeny can spread between cells to cause gene silencing.

21 r1 is essential for heterochromatin-mediated gene silencing.

22 for mesenchymal stromal cells function using gene silencing.

23 Xist and, separately, helps trigger X-linked gene silencing.

24 6)A methyltransferase, impairs XIST-mediated gene silencing.

25 egy for tuning pharmacokinetics and systemic gene silencing.

26 is a key chromatin regulator responsible for gene silencing.

27 re able to promote statistically appreciable gene silencing.

28 fe, site-specific delivery and modulation of gene silencing.

29 hylation marks traditionally associated with gene silencing.

30 g chromatin modifying proteins for effective gene silencing.

31 ius, but not HRDE-1, for small RNA-dependent gene silencing.

32 (H3K9me3), which is typically implicated in gene silencing.

33 ressive histone mark that is associated with gene silencing.

34 d metabolism were confirmed by virus-induced gene silencing.

35 ired to initiate small-RNA-induced heritable gene silencing.

36 C1-C with function of the PRC1 in epigenetic gene silencing.

37 A-repeat domain of Xist and is required for gene silencing.

38 H-NS family members in DNA organization and gene silencing.

39 expressed in cancer cells and contributes to gene silencing.

40 H3K27 (H3K27me3) is implicated in epigenetic gene silencing.

41 ant rate-limiting factors for miRNA-mediated gene silencing.

42 ved in specific transcriptional cascades and gene silencing.

43 ew layer of regulation in small RNA-mediated gene silencing.

44 (HP1) induced H3K9me3, DNA methylation, and gene silencing.

45 1, inducing local chromatin condensation and gene silencing.

46 )-based siRNA nanocarrier for NIR-controlled gene silencing.

47 3, a modification associated with epigenetic gene silencing.

48 the microRNA-guided Argonaute 1 complex and gene silencing.

49 ve model whereby WIG1 controls AGO2-mediated gene silencing.

50 cargo capacity and have mostly been used for gene silencing.

51 ically on histone H3K36me2,3 led to enhanced gene silencing.

52 analysis was performed through virus-induced gene silencing.

53 t also blocks NMDA-stimulated miRNA-mediated gene silencing.

54 nvasion were determined using siRNA-mediated gene silencing.

55 known as key players in post-transcriptional gene silencing(1), while recent studies on prokaryotic A

56 ion RNA devices performed better in terms of gene silencing, activation ratio and ligand sensitivity

57 tify RNAi-based nanotherapeutics with potent gene silencing activity and will inform additional precl

58 y (QP) modeling indicated the major cause of gene silencing activity loss depended on drug concentrat

59 hanisms by which polyanion drugs reduced the gene silencing activity of Lipoplex, a complex of small

60 of three mechanisms to the eventual loss of gene silencing activity.

61 s decoy activity and seed sequence-dependent gene silencing activity.

62 activated glycolytic enzymes we evaluated by gene silencing, aldolase A (ALDOA) blockade produced the

63 Gene silencing also revealed that Snail enhanced the per

64 In this study, we used gene silencing and a directional MF to show that mammali

65 Gene silencing and activation are critical for intestina

66 CB2-selective antagonists, gene silencing and an inhibitor of SL biosynthesis parti

67 nregulation, thereby promoting EZH2-mediated gene silencing and cancer stem cell property compared wi

68 We employed live-cell imaging, gene silencing and coimmunoprecipitation to investigate

69 A in host plants can trigger specific fungal gene silencing and confer resistance to fungal pathogens

70 e structures that accommodate transcription, gene silencing and DNA replication.

71 However, while both p27(kip1) gene silencing and downregulation by Skp2 overexpression

72 This was confirmed by specific LCK gene silencing and ex vivo combined treatment of cells f

73 Moreover, gene silencing and gene promoter experiments indicated t

74 nces in genome-modulating technologies, like gene silencing and genome editing, are providing ability

75 and discuss their functional implications in gene silencing and genome organization.

76 HnrnpK, which participates in Xist-mediated gene silencing and histone modifications but not Xist lo

77 DNA methylation in gene promoters leads to gene silencing and is the therapeutic target of methylat

78 n with antisense drugs can lead to efficient gene silencing and is thus a potentially effective thera

79 lationship between microRNA (miRNA)-mediated gene silencing and low-dose irradiation (LDIR) responses

80 f inserts was correlated with greater target gene silencing and more extensive visible silencing phen

81 n in Fib-MCs in experiments utilizing raptor gene silencing and overexpression of dominant-inhibitory

82 an important regulator of cotranscriptional gene silencing and post-transcriptional RNA metabolism.

83 interactions implicated in processes such as gene silencing and pre-mRNA splicing.

84 me P450-type gene, CYP76AD6, and carried out gene silencing and recombinant expression assays in Nico

85 CAA1 siRNA for targeting, imaging, delivery, gene silencing and regression of gastric cancer in anima

86 ecruitment, in turn abrogating Xist-mediated gene silencing and reversing Xist-induced chromatin inac

87 ation associated with defective X chromosome gene silencing and sex chromosome condensation.

88 optimized RNAi NPs (<70 nm) showed efficient gene silencing and significant inhibition of tumor growt

89 factors that may be involved in gamma-globin gene silencing and their potential manipulation for ther

90 uniform in size, while effectively mediating gene silencing and transgene expression.

91 By mutation analysis, gene silencing and transgenic overexpression, we show th

92 ylation, this change was not associated with gene silencing and was essentially absent in AMLs with D

93 ounteract antiviral responses, including the gene-silencing and innate immunity machineries.

94 votal roles in regulating plant development, gene silencing, and adaptation to environmental stress.

95 A combination of phylogenetic analyses, gene silencing, and biochemical analyses coupled with st

96 ts promoter region, which is associated with gene silencing, and increases in a repressive histone ma

97 Using mapping-by-sequencing, virus-induced gene silencing, and molecular modeling, we identified th

98 complexes, is a regulator of miRNA-mediated gene silencing, and possibly shuttles to stress granules

99 Pharmacological studies, gene silencing, and receptor expression-specific cell st

100 APC and thrombin was analyzed by functional, gene silencing, and signaling assays.

101 ntamoeba, we developed an RNAi-based trigger gene-silencing approach inE.

102 pressive complex 1 (PRC1) in development and gene silencing are thought to involve long non-coding RN

103 During microRNA (miRNA)-guided gene silencing, Argonaute (Ago) proteins interact with a

104 erally associated with H3K27 methylation and gene silencing, as a member of the polycomb repressor 2

105 Marker gene silencing assays and genome-wide RNA sequencing rev

106 Altered histone modifications implicated in gene silencing associate with aberrant autoantigen expre

107 ns in a linear pathway with PRC1 in inducing gene silencing at lesions.

108 icient for RNAi-dependent co-transcriptional gene silencing at pericentromeric DNA repeats.

109 Arabidopsis SAC3B dysfunction causes gene silencing at transgenic and endogenous loci, accomp

110 culatory half-life, hepatic accumulation and gene silencing; based on the number of siRNA cholesteryl

111 ion is a key epigenetic mechanism for stable gene silencing, but is correlated with expression when l

112 Small-RNA (sRNA)-guided transcriptional gene silencing by Argonaute (Ago)-containing complexes i

113 ecular mechanics of mammalian miRNA-mediated gene silencing by coordinated target mRNA recognition, c

114 (miRNAs) play an important role in targeted gene silencing by facilitating posttranscriptional and t

115 Gene silencing by heterochromatin is proposed to occur i

116 Gene silencing by Polycomb complexes is central to eukar

117 Disruption of gene silencing by Polycomb protein complexes leads to ho

118 nown as JMJ12) counteracts Polycomb-mediated gene silencing by removing methyl groups from trimethyla

119 Efficient gene silencing by RNA interference (RNAi) in vivo requir

120 Eukaryotic Argonaute proteins induce gene silencing by small RNA-guided recognition and cleav

121 of DDX5 stabilized SUZ12- and PRC2-mediated gene silencing, by displacing the RNA-binding E3 ligase,

122 sor CML38, a protein related to regulator of gene silencing calmodulin-like proteins (rgsCaMs).

123 that notion, we find that sequence-specific gene silencing can be triggered by long dsRNAs in differ

124 Three Spr1 gene silencing cassettes were constructed around sense,

125 ion with small-molecule inhibitors and siRNA gene silencing, cathepsin S was identified as the major

126 erved chromatin binding proteins involved in gene silencing, chromosome packaging, and chromosome seg

127 complex genes (an ovarian steroid-regulated gene silencing complex) in untreated LCLs from women wit

128 in the isolation of the posttranscriptional gene-silencing components RNA-DEPENDENT RNA POLYMERASE1

129 ibited by local external fields representing gene silencing compounds such as kinase inhibitors, disr

130 ARGONAUTE3 (a key component of sRNA-mediated gene silencing), did not display major phenotypic defect

131 Mechanistically, p53 induced by RUNX1 gene silencing directly binds to CBFB promoter and stimu

132 BMI1 also participates in gene silencing during DNA damage response, but the preci

133 key mechanism by which PcG proteins maintain gene silencing during mouse development.

134 ted by inflammation and MMR proteins lead to gene silencing during tumorigenesis, revealing a novel m

135 into substantially improved liver exposure, gene silencing efficacy and duration of effect in mice.

136 NA polyplexes was developed and screened for gene silencing efficacy in vitro and in vivo with the go

137 The use of the YSK12-MEND resulted in a gene silencing efficiency in excess of 90%, with a media

138 -siRNA-complexed NPs exhibited excellent GFP gene silencing efficiency in GFP-MDA-MB-468 TNBC cells w

139 ve dose (ED50) of 1.5nM, whereas the maximum gene silencing efficiency of Lipofectamine RNAiMAX was l

140 VEGF gene silencing efficiency of PAM-ABP/siRNA polyplexes wa

141 e disruptive activity, biocompatibility, and gene silencing efficiency.

142 lmost no toxicity, and an excellent in vitro gene silencing efficiency.

143 roRNAs (amiRNA) provide a new feature in the gene silencing era.

144 Localization and gene silencing experiments provide a basis for understan

145 Gene silencing experiments targeting alpha1D reduced the

146 pt localization in specific leaf tissues and gene-silencing experiments of both classes of CPR all po

147 T-cell functional assays in vitro and gene-silencing experiments were also performed.

148 es of siRNA-L2 facilitated significant tumor gene silencing for 7 d after two i.v. doses.

149 in medical therapeutics, virus control, and gene silencing for disease treatments, RNA-cleaving DNAz

150 s autonomously folded helices, which promote gene silencing, from helices folded with siRNA, which do

151 We used anterograde tracing, viral-mediated gene silencing, functional disconnection strategies, pha

152 We use gene silencing, gene expression analysis, genetic mappin

153 e the role of 5-methylcytosine (5mC) in FMR1 gene silencing has been studied extensively, the role of

154 The tuneable sequence and combined gene silencing, immunostimulatory and cytotoxic capacity

155 Here we use mutants and gene silencing in a fern species to identify a core regu

156 s of Fetuin-A (FetA) were conducted by using gene silencing in a mouse asthma model, human dendritic

157 istribution and safety profiles for clinical gene silencing in a particular tissue, this will open th

158 ucleosome density necessary for gamma-globin gene silencing in adults, and that LRF confers its repre

159 y to keep small RNA-guided transgenerational gene silencing in check.

160 Gene silencing in cultured EC and EC-specific genetic de

161 , only viral vectors have achieved efficient gene silencing in DCs.

162 plex in fission yeast drives transcriptional gene silencing in heterochromatin through cooperation wi

163 n regulation of transcription and epigenetic gene silencing in human cells by revisiting these earlie

164 gonucleotides provided the first evidence of gene silencing in injured brain parenchyma by systemical

165 gainst cyclin D1, CD38-targeted LNPs induced gene silencing in MCL cells and prolonged survival of tu

166 no device [YSK12-MEND]), greatly facilitated gene silencing in mouse DCs.

167 PRC1 and PRC2 are key mediators of heritable gene silencing in multicellular organisms.

168 methyltransferase (RNMT) using virus-induced gene silencing in opium poppy resulted in a significant

169 ting specific miRNAs to induce cross-kingdom gene silencing in pathogenic fungi and confer disease re

170 fying suitable target genes for host-induced gene silencing in pathogens for generating novel disease

171 Complementary evidence obtained through gene silencing in planta and heterologous expression in

172 asiRNAs) for efficient and specific targeted gene silencing in plants.

173 try into the cytosol of early embryos causes gene silencing in progeny.

174 itis elegans These differences are caused by gene silencing in some cells and are actively suppressed

175 obust and scalable strategy based on arrayed gene silencing in the human beta-cell line EndoC-betaH1.

176 e results reveal the centrality of regulated gene silencing in the uterine adaptation to pregnancy an

177 ant promoter systems to drive hpRNA mediated gene silencing in transgenic, hairy roots.

178 ins to chromatin, initiating methylation and gene silencing in tumors.

179 uit PRC2, and are required for PRC2-mediated gene silencing in vivo.

180 th requirements that mirror yeast epigenetic gene silencing in vivo.

181 Selective NPs were also able to mediate gene silencing in xenograft and orthotopic tumors via i.

182 from mouse brains, we demonstrated that LRP1 gene silencing increases expression of proinflammatory m

183 One mode of gamma-globin gene silencing involves a GATA-1.FOG-1.Mi2beta repressor

184 RNA-mediated transcriptional gene silencing is a conserved process where small RNAs t

185 Post-transcriptional gene silencing is a promising therapy for the monogenic,

186 lyses of different tissues and virus-induced gene silencing is an efficient way to identify host prot

187 Transcriptional gene silencing is associated with 24-nt sRNAs and RNA-di

188 This regulated gene silencing is carried out by Polycomb group (PcG) pr

189 xr mutations, indicating that selective rRNA gene silencing is chromosome 2-specific.

190 We find that Sp7 gene silencing is mediated by DNA methyltransferase1/3 (

191 ly, these results reveal that selective rRNA gene silencing is not regulated gene by gene based on me

192 onstrate that PTPRT promoter methylation and gene silencing is reversible in HNSCC cells, leading to

193 c Xist RNA induction and subsequent X-linked gene silencing is sex specific in embryos and in differe

194 Gene silencing is stably maintained during development,

195 Such persistent gene silencing is thought to result from sequence-specif

196 t the precise downstream function of BMI1 in gene silencing is unclear.

197 ly associated with the stable maintenance of gene silencing, is also dynamically regulated in respons

198 Using gene silencing it was demonstrated that Snail positively

199 Moreover, CXCL8 and CXCL1 gene silencing made resistant cells more sensitive to OX

200 ndings suggest that heterochromatin-mediated gene silencing may occur in part through sequestration o

201 Together, these findings reveal a critical gene silencing mechanism in developing mammalian hearts

202 This method combines gene silencing mediated by an artificial mirtron with de

203 ould potentially offer an efficient means of gene silencing-mediated therapy in the HIV-infected brai

204 instead of directly targeting IL-6 mRNA for gene silencing, miR-26 diminishes IL-6 transcription act

205 between DNA methylation, a model epigenetic gene silencing modification, and autoantigen gene expres

206 erochromatic repression, a heritable form of gene silencing, occur throughout the growth of Saccharom

207 lated with an increase in hepatic Factor VII gene silencing of 28% (rHSA/siRNA) compared to 4% (naked

208 Targeted gene silencing of BADC isoform 1 in A. thaliana signific

209 ors of cell death triggered by virus-induced gene silencing of BAK1/SERK4 on Arabidopsis knockout col

210 Gene silencing of BRD4, an important BET protein, and ch

211 in B16 cells, and c-Myc siRNAs can cause the gene silencing of c-Myc and thus the apoptosis of cells.

212 Simultaneous RNAi gene silencing of ClAQP1 and ClGlp1 significantly reduce

213 Overexpression and gene silencing of CypA verified osteogenic and anti-oste

214 ants avert inappropriate posttranscriptional gene silencing of endogenous coding genes by using RNA s

215 tor activation was responsible for mediating gene silencing of IL-27p28 and EBV-induced gene 3.

216 RNAi-mediated gene silencing of il17a in fibrotic mice arrested the pr

217 Here, we demonstrate that gene silencing of KIND1 decreased keratinocyte prolifera

218 Virus-induced gene silencing of NOG1 compromised nonhost resistance in

219 Secondly, conditional gene silencing of PKC1 by RNA interference led to severe

220 Virus Induced Gene Silencing of TaU4 in wheat leaves resulted in delay

221 Gene silencing of TET2 obviously diminished NaCl-induced

222 duals with Elstar apples which had undergone gene silencing of the major allergen of apple, Mal d 1,

223 Transcriptional gene silencing of this regulatory element repressed TERT

224 Posttranscriptional gene silencing of TOR using RNA interference (RNAi) show

225 In this work, we report that virus-induced gene silencing of transcripts encoding a putative RPC5-l

226 inflammatory cytokines is reduced by ex vivo gene-silencing of miR-34a.

227 rmation, we next investigated the effects of gene silencing on this pathway.

228 ys in mMSCs was carried out in vitro through gene silencing or chemical inhibition of key components.

229 Interestingly, gene silencing or editing experiments revealed that SNAT

230 traits in a nonmodel system not conducive to gene silencing or selective breeding are useful for othe

231 ly distinct from the RNA interference (RNAi) gene-silencing pathway.

232 DNA methylation and post-transcriptional gene silencing play critical roles in controlling infect

233 ethylase IBM1 suppresses DNA methylation and gene silencing, primarily by targeting genic regions in

234 that EZH2 plays a critical role in the FMR1 gene silencing process and that its inhibition can prolo

235 euchromatic and heterochromatic lncRNA-based gene silencing processes.

236 Gene silencing produced two genetically modified apple l

237 he human body contains a set of programmable gene-silencing proteins named Argonaute.

238 16 tested candidates (83%) are required for gene silencing, providing a substantial increase in the

239 pical structure, whereas posttranscriptional gene silencing (PTGS) eliminates both aberrant and funct

240 between the exosome and posttranscriptional gene silencing (PTGS) in regulating CER3 transcript leve

241 Posttranscriptional gene silencing (PTGS) of transgenes involves abundant 21

242 r by targeting mRNAs via posttranscriptional gene silencing (PTGS).

243 After Msx2 gene silencing, real-time quantitative RT-PCR data showe

244 est that miRNA-mediated post-transcriptional gene silencing relies primarily on AGO3 in Chlamydomonas

245 recise mechanism of mammalian miRNA-mediated gene silencing remains to be elucidated.

246 genes are excluded from SAHF-mediated global gene silencing remains unclear.

247 using virus- or artificial microRNA-mediated gene silencing resulted in accelerated leaf senescence a

248 Moreover, rpoA gene silencing resulted in suppression of its message as

249 FMR1 gene silencing results in fragile X syndrome (FXS), the

250 Gene silencing revealed that NaJAZi functions as a flowe

251 Gene silencing revealed that STAT4 was required for IL-6

252 encompass transgenic, targeted mutagenesis, gene silencing (RNA interference), and genome editing (C

253 regeneration, we completed an unbiased RNAi gene-silencing screen across most phosphatases in the ge

254 This so-called spray-induced gene silencing (SIGS) strategy of disease control is pot

255 for monitoring the impact of allele-specific gene silencing strategies currently being explored as th

256 rades QS molecules produced by P. aeruginosa Gene silencing studies confirmed that enhanced clearance

257 f osteosarcoma cells, whereas shRNA-mediated gene silencing suppressed these effects.

258 ined effect after transplantation.The use of gene silencing techniques in the treatment of post-trans

259 RNA interference (RNAi) gene silencing technologies have shown significant poten

260 as cloned as a suppressor of transcriptional gene silencing (TGS) from a forward genetic screen.

261 d DNA methylation (RdDM) and transcriptional gene silencing (TGS) of transposable elements (TEs).

262 cells to achieve functional transcriptional gene silencing (TGS).

263 oters deposits H3K9me3 domains, resulting in gene silencing that can be reversed upon washout of the

264 demethylase to counteract Polycomb-mediated gene silencing that regulates plant development, includi

265 In miRNA-mediated gene silencing, the physical interaction between human A

266 olycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methy

267 DNA methylation abnormalities and associated gene silencing, through inhibiting DNA methyltransferase

268 in processes ranging from microRNA-dependent gene silencing to alternative splicing.

269 our approach combined several mutations with gene silencing to inactivate multiple members of the PHT

270 promoter DNA hypermethylation and associated gene silencing to reexpress key genes.

271 ions where it contributes to heterochromatin gene silencing together with RNA interference (RNAi).

272 However, the lack of gene-silencing tools in E. invadens has limited the mole

273 This is surprising, as defective gene silencing underlies developmental abnormalities and

274 VEGFR3 gene silencing upregulated VEGFR2 protein levels and pho

275 1 SL and 2 SL by a brome mosaic virus-based gene silencing vector in maize indicated that protein di

276 s revealed a striking similarity of RXRalpha gene silencing versus IL-6 induced negative gene regulat

277 eins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts.

278 Virus-induced gene silencing (VIGS) and transient expression of Phytop

279 Through virus-induced gene silencing (VIGS) in a related crop species, maize (

280 In plants, virus-induced gene silencing (VIGS) is a popular tool for functional g

281 Virus-induced gene silencing (VIGS) is used extensively for gene funct

282 Virus-induced gene silencing (VIGS) of the LMI1-like gene in an okra v

283 We used a virus-induced gene silencing (VIGS) vector derived from the geminiviru

284 We developed an efficient virus-induced gene silencing (VIGS) vector for maize based on a natura

285 gnition in N. benthamiana, and virus-induced gene silencing (VIGS) was employed to determine the role

286 or foreign gene expression and virus-induced gene silencing (VIGS).

287 An intron-containing hairpin RNA-mediated gene silencing was carried out in endosperm-specific man

288 To test the impact of Xist RNA on X-linked gene silencing, we ectopically induced endogenous Xist b

289 tness of factors in initiating PIWI-directed gene silencing, we employed a Piwi-interacting RNA (piRN

290 loss-of-function screen using virus-induced gene silencing, we identified Gossypium hirsutum GhWRKY5

291 known to be involved in posttranscriptional gene silencing were required to generate diRNAs.

292 structures and cause potent cytotoxicity and gene silencing when delivered to cancer cells.

293 and tightly regulated genes may cause target gene silencing when perturbed by activation probes.

294 histone H3 lysine 27 (H3K27me3) is linked to gene silencing, whereas H3K4me3 is associated with gene

295 mately leading to the loss of miRNA-mediated gene silencing, which may contribute to disease etiology

296 ker makes DNA contacts that are required for gene silencing, while chromosome compaction does not app

297 nal activation as well as the maintenance of gene silencing, while H2AX is important in DNA damage re

298 splicing and is critical for miRNA-mediated gene silencing with a distinct preference of target miRN

299 or antisense strands triggered RNAi-mediated gene silencing with efficiencies comparable to that of 2

300 cleotide drugs can be used as a strategy for gene silencing within a potentially therapeutic context.