ライフサイエンスコーパス: gene structure

1 options and graphic representation of fusion gene structure.

2 ing of the evolution of gene copy number and gene structure.

3 ds for genomic coordinates, nomenclature and gene structure.

4 ciate the increasing complexity of mammalian gene structure.

5 esigning and testing potential indicators of gene structure.

6 ron-exon structure, and combines them into a gene structure.

7 substrate specificity, tissue expression and gene structure.

8 d directly sequenced, confirming the genomic gene structure.

9 trategies by identifying genes and improving gene structure.

10 cies to accurately document the evolution of gene structure.

11 gene events that did not dramatically alter gene structure.

12 ouse CD30 represents the ancestral mammalian gene structure.

13 es which are predicted with exactly the same gene structure.

14 erver to enhance the analysis and display of gene structure.

15 ted with a loss of similarity in intron/exon gene structure.

16 ects that vary by their location relative to gene structure.

17 still unclear why cells utilize this unusual gene structure.

18 and to create a mouse with a humanized fpgs gene structure.

19 and categorize binding sites with respect to gene structure.

20 raints and, where available, knowledge about gene structure.

21 organization of the proposed 8-intron/9-exon gene structure.

22 litate rapid visualization and assignment of gene structures.

23 typically biased toward known and predicted gene structures.

24 l in the context of genomic features such as gene structures.

25 e testing on two fungi with vastly different gene structures.

26 e and branchpoint site, confirming predicted gene structures.

27 rkov models to ensure the reliability of the gene structures.

28 ces by sequencing RT-PCR products to confirm gene structures.

29 of splice variants or updates to another 19 gene structures.

30 scripts or counting reads that overlap known gene structures.

31 nd analyzed relative to predicted Drosophila gene structures.

32 ough overlapping sequences to yield accurate gene structures.

33 ne and are biased toward known and predicted gene structures.

34 sequences that lead to the formation of new gene structures.

35 rms iterative training and generates initial gene structures.

36 of alternative splicing in generating novel gene structures.

37 hese, 192 in G089 and 106 in PC346C affected gene structures.

38 support that plant genomes have very complex gene structures.

39 e, GSDraw, for drawing schematic diagrams of gene structures.

40 der to confirm their existence and predicted gene structures, a high-throughput method of rapid ampli

41 of other Drosophila species and have similar gene structure across species despite low levels of sequ

42 t new genes arise by duplication of existing gene structures, after which relaxed selection on the ne

43 The gene structures agreed partially but not completely with

44 Delineation of global organization, gene structure, alternative splice forms, protein simila

45 similarities among all three FXR proteins in gene structure, amino acid sequence, expression pattern

46 Gene structure analyses revealed that these SPIs contain

47 tion with protein structural predictions and gene-structure analyses on a whole-genome scale to find

48 Together, phylogenetics and gene structure analysis suggests a parsimonious path for

49 s from a genomic database, (ii) characterize gene structure and (iii) perform phylogenetic analysis.

50 increasingly accessible method for studying gene structure and activity on a genome-wide scale.

51 can be used to simultaneously find both the gene structure and alignment of two syntenic genomic reg

52 We describe a probabilistic framework for gene structure and alignment that can be used to simulta

53 mapped more than 120 million reads to define gene structure and alternative splicing events and to qu

54 is study also illustrates how differences in gene structure and alternative splicing present unique p

55 rected acyclic graph (DAG) representation of gene structure and alternative splicing.

56 prehensive, high-quality annotation of their gene structure and boundaries, which is currently lackin

57 has been studied in yeast, the complexity of gene structure and cellular function in metazoan cells h

58 8 subgroups, which was further supported by gene structure and conserved motif analyses.

59 hromosome location, gene duplication status, gene structure and conserved motif analysis, as well as

60 he plant research community for the study of gene structure and evolution.

61 e nervous system of vertebrates, the galanin gene structure and expression and the consequences of ga

62 ification complexes in regulating heat shock gene structure and expression in Saccharomyces cerevisia

63 In the present study, the gene structure and expression of KSHV ORF56 (primase), O

64 n An. gambiae have considerable variation in gene structure and expression patterns.

65 amongst other approaches, investigations of gene structure and expression, the role of astrocytes an

66 uropeptides display a marked conservation in gene structure and expression, yet diversity in the gene

67 En masse analysis of gene structure and function by array technologies will h

68 -forming oligonucleotides (TFOs) to modulate gene structure and function has potential as an approach

69 r understanding of the relationships between gene structure and function in Candida albicans.

70 Thus, the hIL10BAC mouse is a model of human gene structure and function revealing tissue-specific re

71 es us with a powerful tool for investigating gene structure and function.

72 nsfer, trans-splicing, and simplification of gene structure and gene content that parallel simplifica

73 ineages, in striking contrast to patterns of gene structure and genome organization, there appears to

74 cific issues such as determination of normal gene structure and identification of abnormal genome str

75 We investigated the gene structure and organization and demonstrated, for th

76 oad applications for analyzing and modifying gene structure and organization of complex genomes.

77 markers and a general lack of information on gene structure and organization.

78 Studies of the gene structure and overlap pattern showed that only a sm

79 pose of this study was thus to elucidate the gene structure and pattern of expression, providing info

80 luding changes in gene content, codon usage, gene structure and post-transcriptional modifications su

81 The gene structure and predicted amino acid sequence of chkI

82 udoobscura and D. virilis and compared their gene structure and predicted amino acid sequences with P

83 The gene structure and primary sequence of prepro-osteocalci

84 Gene structure and protein characteristics show that SCP

85 been identified that extend the known Nanog gene structure and protein coding capacity.

86 The conserved gene structure and protein sequences suggest that the ho

87 ne promoters from ChIP-seq to explore lncRNA gene structure and regulation, as well as lncRNA transcr

88 Here we review XOR gene structure and regulation, protein structure, enzymo

89 To understand their gene structure and regulation, we screened a genomic lib

90 t can be divided into four clusters based on gene structure and sequence homology.

91 ThSOS1 shares gene structure and sequence with A. thaliana SOS1 includ

92 compact genome shows conserved gene content, gene structure and synteny in relation to the human and

93 collect a variety of types of evidence about gene structure and synthesize the results, which can the

94 of this study was to characterize the wit3.0 gene structure and the function of its deduced peptide.

95 We clarify gene structure and the murine coding sequence, and we de

96 The conserved gene structure and the similarity in postnatal expressio

97 Here we report the gene structure and transcription regulation of the human

98 ow report work clarifying details of NRXN3's gene structure and variants and documenting association

99 genes coexpressed with their genes, and (6) gene structure and whether genetic mutants exist in thei

100 han 6000 gene annotations including 80 novel gene structures and about 500 translational start sites.

101 Our EST-Genome-Browser can display annotated gene structures and cDNA-genome alignments at scales fro

102 ics statistics in small genomic windows with gene structures and chromatin states yields a rich, high

103 hich contains approximately 6500 intron-rich gene structures and encodes a transcriptome abundant in

104 locally or on a remote HPC cluster), predict gene structures and gene structure quality, and display

105 s possess unusual features in their inferred gene structures and genome organization.

106 oes not depend on any existing annotation of gene structures and is capable of finding novel splice j

107 rate estimates for gene expression, complete gene structures and new transcript isoforms, as well as

108 ded new insights into the characteristics of gene structures and promoters within this major crop spe

109 ra and Drosophila virilis and compared their gene structures and protein sequences with the rest of t

110 Annotations of gene structures and regulatory elements can inform genom

111 The accurate prediction of higher eukaryotic gene structures and regulatory elements directly from ge

112 MGI predicts homologies, displays gene structures and supporting information for annotated

113 In this work, we examine gene structures and their relation to the number of tiss

114 ving genome annotation, determining accurate gene structures and their variations, and exploring impo

115 sent novel algorithms, specific to bacterial gene structures and transcriptomes, for analysis of bact

116 resent new algorithms, specific to bacterial gene structures and transcriptomes, for analysis of RNA-

117 erformed forward simulations under realistic gene-structure and selection scenarios to investigate wh

118 Many genes' structures and expression are altered directly by

119 lleles is often laborious, limited by target gene structure, and at times, prone to incomplete condit

120 Subsequently, we analyzed the phylogeny, gene structure, and chromosomal distribution of BAHD mem

121 ysis of its amino acid sequence, comparative gene structure, and conserved synteny, chicken DNase II

122 Numerous aspects of genomic architecture, gene structure, and developmental pathways are difficult

123 orrelate well with the nuclear architecture, gene structure, and expression observed in cells, sugges

124 onserved between human and mouse, its locus, gene structure, and function are preserved.

125 features of lncRNAs, including promoter and gene structure, and protein-coding potential.

126 on and dominance of new mutations, arbitrary gene structure, and user-defined recombination maps.

127 Accurate gene structure annotation is a challenging computational

128 Accurate gene structure annotation is a fundamental but somewhat

129 rovide relevant biological insights into the gene structure annotations being compared.

130 y control, and dissemination of high-quality gene structure annotations challenging.

131 -alone, third-party tool for post-processing gene structure annotations generated by external computa

132 plication for pairwise comparison of sets of gene structure annotations.

133 Furthermore, alterations in CD68 gene structure are associated with failings in mRNA spli

134 Such differences in gene structure are perceived to extend to simpler mechan

135 sEH evolution and gene structure are then discussed before human small nuc

136 ryza sativa), the exon-intron boundaries for gene structures are annotated by spliced alignment of ES

137 The Fugu nAChR gene structures are considerably more diverse than those

138 reas the orthologous human and mouse SULT2B1 gene structures are identical, the rat SULT2B1 gene stru

139 e annotated as "hypothetical protein," whose gene structures are predicted solely by computer algorit

140 tand the extent to which zebrafish genes and gene structures are related to orthologous human genes.

141 high-resolution map of R-loops and identify gene structure as a critical determinant of R-loop forma

142 (87.2%) but had different overall functional gene structures as revealed by two datasets of 12-day ti

143 spired by Li and Wong (2001), we developed a gene structure-based algorithm to determine the relative

144 ompute probabilities for predicted exons and gene structures being correct under the assumed model.

145 annotations that account for differences in gene structure between individuals or strains.

146 Our method does not insist on conserved gene structure between the two sequences, thus making it

147 ormalization obscured tile signal changes at gene structure boundaries.

148 Vega displays only manually annotated gene structures built using transcriptional evidence, wh

149 +/-10) members per genome that share a basic gene structure but show high sequence diversity, primari

150 Unique physiological, functional, and gene structure changes allow Spalax species to survive l

151 This first phylogenetically diverse study of gene structure changes offers insights into the mode and

152 ion was studied by comparing the patterns of gene structure changes, alternative splicing (AS), and c

153 ps transcript annotations onto them, detects gene-structure changes and their possible repercussions,

154 The gene structure characterization led to the identificatio

155 L1A gene on chromosome 15 revealed a complex gene structure comprising at least 28 exons.

156 Analyses of the mouse and rat amelogenin gene structures confirmed that exon 8 arose in a duplica

157 lows visualization of array images, signals, gene structure, conservation, and DNA sequence and motif

158 rexpression phenotype, gene interaction, and gene structure correction.

159 The accumulation of nested gene structures could not be attributed to any obvious f

160 nent of the application contains pre-defined gene structures derived from mRNA transcript sequences f

161 n the cDNA populations with about 38% of the gene structures differing from their predictions.

162 d, evaluate their genome-wide regulation and gene structure, discuss emerging evidence for their mode

163 ne structures are identical, the rat SULT2B1 gene structure diverges.

164 of these algorithms, prediction of complete gene structures, especially for alternatively spliced pr

165 nomic research, with integrated genomic DNA, gene structure, EST/ splicing and cross-species ortholog

166 The program generates accurate gene structures, even in the presence of substantial pol

167 se sequencing of the ENCODE regions to study gene structure evolution in mammalian genomes.

168 Reconstruction of parsimonious scenarios of gene structure evolution in paralogous gene families in

169 The gene structure evolution of orthologous gene groups was

170 revious studies have revealed two models for gene structure evolution through the loss of introns: RN

171 nsights into the mode and tempo of mammalian gene structure evolution.

172 It can be a valuable resource for studies of gene structure evolution.

173 Here, we describe the phylogeny, gene structure, evolutionary history, genomic organizati

174 ever, studies on how various ABC transporter gene structures evolved is still absent.

175 sms, and biological relevance with regard to gene structures, expression, and regulation.

176 iced reads, and optionally information about gene structure extracted from cDNA sequence databases.

177 sequences, and Genomewise, which provides a gene structure final parse across cDNA- and EST-defined

178 This is an unusual gene structure for Drosophila.

179 that accurately identifies and predicts the gene structure for short peptides with one or two exons.

180 We have annotated the gene structure for the members of this family and have c

181 SLAM is able to reliably predict gene structures for any suitably related pair of organis

182 ts to accurately reconstruct the full-length gene structures for most known expressed genes.

183 This suggests that any novel gene structures formed by these interchromosomal events

184 signed to automate the process of predicting gene structure from multiple sources of evidence, with r

185 e these interactions in vivo and to evaluate gene structure-function relationships that affect inner

186 circuit design, information processing, and gene-structure-function relationships that are not appar

187 GenPlay displays tracks adapted to summarize gene structure, gene expression, repeat families, CPG is

188 f every plant gene at the level of sequence, gene structure, gene family and genome organization, whi

189 ace sequence enable the detailed analysis of gene structure, gene family organization and phylogeneti

190 at will facilitate accurate determination of gene structures, genome annotation, and exploration of t

191 embl provides an excellent means for storing gene structures, genome features, and sequence, but it d

192 M is used to find the most likely underlying gene structure given a DNA sequence.

193 e-rich-like, late-envelope protein genes) to gene structure, groupings, and chromosomal organization,

194 ue and global impact on gene composition and gene structure has not been observed for any other trans

195 Complete and partial gene structures identified by this method were used to i

196 g the high conservation of the polyubiquitin gene structure in higher plants, the observed enhancemen

197 NDE1 has a different gene structure in human and mouse resulting in the produ

198 swer these questions, we have begun studying gene structure in nematodes related to Caenorhabditis el

199 ides valuable insights into the evolution of gene structure in plant genomes.

200 ides valuable insights into the evolution of gene structure in plant genomes.

201 and focused on the insights they provide for gene structure in the genome of this recently sequenced

202 ns, we carried out a detailed analysis of AR gene structure in the LuCaP 86.2 and CWR-R1 models of CR

203 visually appealing displays of the predicted gene structures in addition to detailed sequence alignme

204 Orthologous gene structures in eight vertebrate species were compare

205 GHMPs can be used to predict complete shared gene structures in multiple primate sequences.

206 rrect gene annotations, and numerous unusual gene structures, including abundant stop-codon readthrou

207 of the human TBK1 gene (native promoter and gene structure) incorporated into the mouse genome (Tg-T

208 ison of their predicted protein features and gene structures indicated the presence of two distinct s

209 ional analysis of a genome requires accurate gene structure information and a complete gene inventory

210 tabase; (iv) a statistical summary of global gene structure information for each species and its comp

211 : confounding of probe sequence content with gene structure (intron/exon) sequence content.

212 akpoints in genes, we identified seven human gene structures involved in signaling pathways (DEPDC4,

213 use and man, a detailed understanding of its gene structure is important for both diagnostic and stru

214 detailed statistical analysis of Arabidopsis gene structure is presented including intron and exon le

215 This unique gene structure is proposed to provide a novel mechanism

216 The gene structure is relatively complex, comprising nine co

217 One hallmark of eukaryotic gene structure is the presence of introns, which are spl

218 Knowing gene structure is vital to understanding gene function,

219 Comparative analysis of gene structures is important for understanding their evo

220 we suggest a new paradigm whereby the unique gene structure of a polycistronic oncomir confers an int

221 ammatory reactions we have characterized the gene structure of human cysteinyl leukotriene receptor t

222 Likewise, gene structure of mouse, chimpanzee, and human BCKD-kina

223 e sequence, to compare these patterns to the gene structure of mtDNA and to see whether these pattern

224 this paper, we present the DNA sequence and gene structure of Mus musculus RNase 6 and examine the e

225 incorporate prior knowledge by 'knowing' the gene structure of one sequence and annotating the other

226 ignature protein sequence of serpins and the gene structure of ov-serpins, with either seven or eight

227 The two-intron gene structure of the Arabidopsis WAK/WAK-Likes is gener

228 The gene structure of the C2-Idf haplotype differs substanti

229 We then determined the gene structures of more than a thousand large intergenic

230 The gene structures of the importin alphas provide insight i

231 We further characterized how the gene structures of the oncogene JAK1 and the tumor suppr

232 shown to be effective in shaping functional gene structures of the systems by statistical analyses.

233 pological properties (i.e., sparsity and hub gene structure) of complex networks in the regularized f

234 perfect we demonstrate that conservation of gene structure on top of nucleotide sequence is a valuab

235 mple evolutionary mechanisms can explain var gene structuring on multiple levels and have important i

236 ches and a graphical viewer for displaying a gene structure pattern diagram linked to the resulting b

237 PD2/NRPE2, NRPE1, and AGO, were analyzed for gene structures, phylogenetic relationships, and protein

238 phila to man, suggesting that the p53 family gene structure plays an essential role in the multiple a

239 odeling of non-canonical introns can enhance gene structure prediction accuracy.

240 nd/or pipelines, or directly integrated into gene structure prediction software implementations.

241 The GeneSeqer@PlantGDB Web server provides a gene structure prediction tool tailored for applications

242 implementations will aid sequence alignment, gene structure prediction, HMM profile training, nanopor

243 s feature allows use of non-cognate ESTs for gene structure prediction, including ESTs derived from d

244 rmatics research such as sequence alignment, gene structure prediction, motif identification, protein

245 ez Gene ID, GO terms, InterPro descriptions, gene structure, protein length, transcript count, and ex

246 ted by the conservation and variation in the gene structure, protein properties, motif patterns, and/

247 atin immunoprecipitation, promoter function, gene structure, pseudogenes, non-protein-coding RNAs, tr

248 te HPC cluster), predict gene structures and gene structure quality, and display output in a public o

249 of AS isoforms, nonsynonymous mutations, and gene structure rearrangements in the wheat lineage, like

250 In wheat, 35% of these gene structure rearrangements resulted in frame-shift mu

251 We describe the gene structure, regulation, signal transduction.

252 y reduced in size and simplified in terms of gene structure relative to those of multicellular eukary

253 e a novel genomic annotation that highlights gene structures, repetitive elements, and chromosome-sca

254 Genome-wide annotation of gene structure requires the integration of numerous comp

255 fferent evolutionary origins, and the mosaic gene structure resulted in confounding phylogenetic sign

256 Analysis of gene structure reveals that these genes diverged prior t

257 Examination of the NKCC gene structure reveals that this dileucine motif is enco

258 CR) and direct sequencing based on predicted gene structures satisfy this need, at least for single-c

259 r, and the two genes evolved differently for gene structure, sequence, and expression pattern.

260 Based on parallels in Msh1 gene structure shared by plants and corals, and their si

261 This unique gene structure, shared by many important miRNA oncogenes

262 derscored by their linked genomic locations, gene structure, shared extracellular domain composition,

263 parative methods employing information about gene structures should be very successful in correctly p

264 In this study, we show that p53 has a gene structure similar to the p73 and p63 genes.

265 ue property of SLAM, namely that it predicts gene structures simultaneously in two organisms, is key

266 lincRNAs, 59% of them novel, with regard to gene structures, species conservation, chromatin accessi

267 Gene structure studies revealed that Cell-1, -3 and -4 a

268 Highly conserved but distinct gene structures suggest that xenopsins and ciliary opsin

269 We analyzed protein sequence, gene structure, synteny, and phylogenetics to identify G

270 of odorant receptors (Ors) with a nine-exon gene structure that have undergone a massive expansion i

271 r identifying possible functional changes in gene structure that may result from sequence variants.

272 The method also keeps 98% of RefSeq gene structures that are correctly predicted by TWINSCAN

273 important and ancient feature of eukaryotic gene structure, the existence of which has likely facili

274 coding transcripts, untranslated regions and gene structures, thus improving the existing genome anno

275 g contigs, while simultaneously allowing the gene structure to be predicted by homology.

276 ily in Arabidopsis, which is more similar in gene structure to CLV3 than the other CLE genes.

277 no reports of using genome-wide analyses of gene structure to investigate this.

278 anging from the mechanisms that generate new gene structures to the presence of new genes in differen

279 one of these tools that can predict complete gene structures together with 5' UTRs.

280 ccess a number of common genome analysis and gene structure tools, preconfigured in a self-contained

281 on for individual OGS gene models, including gene structure, transcript variants, functional descript

282 pression profiles revealed the landscapes of gene structures, untranslated regions, and splicing acti

283 thms in this paper: GeneWise, which predicts gene structure using similar protein sequences, and Geno

284 up and study the conservation of exon-intron gene structures using a graphical interface.

285 sifies the location of each peak relative to gene structure, (v) provides information such as the num

286 iants have the potential to disrupt or alter gene structure, variant interpretation efforts stand to

287 Isoprene synthase gene structure was analysed in three poplar species.

288 The gene structure was characterized by PCR amplification an

289 nduced CysLTR2 expression, the human CysLTR2 gene structure was characterized.

290 Gene structure was improved in over 13% of genes, and 65

291 coding region, a detailed analysis of LMX1B gene structure was undertaken.

292 genes are unified by sequence similarity and gene structure, we believe the Bex nomenclature should p

293 confirmed transcription at 38 loci; 33 novel gene structures were delineated by 5' and 3' RACE.

294 These results show that early eukaryotic gene structures were very complex, and that simplificati

295 Its human and rat gene structures were well conserved, composed of 7 exons

296 e and can provide both accurate and complete gene structures when used with the correct evidence.

297 g oncogenes, mir-17-92 has an unconventional gene structure, where one primary transcript yields six

298 DB researchers can study the correlations of gene structure with the properties of the encoded three-

299 conclude that this procedure for elucidating gene structures with native cDNA sequences is cost-effec

300 the striking differences in Dscam and DSCAM gene structures with their conserved functions in molecu