ライフサイエンスコーパス: gene transfer

1 l cord glioma model in pigs using lentiviral gene transfer.

2 biotic resistance, virulence, and horizontal gene transfer.

3 ansformation is a primary mode of horizontal gene transfer.

4 uring this conserved mechanism of horizontal gene transfer.

5 of different proteins shaped by interdomain gene transfer.

6 lysis and drive evolution through horizontal gene transfer.

7 ns for understanding evolution by horizontal gene transfer.

8 netic elements that contribute to horizontal gene transfer.

9 etween nucleus and cytoplasm, and horizontal gene transfer.

10 as nucleases but also can promote horizontal gene transfer.

11 n microbial communities from pathogenesis to gene transfer.

12 been achieved in patients by hepatic in vivo gene transfer.

13 al anti-TASK-1-siRNA (small interfering RNA) gene transfer.

14 bacterial evolution by promoting horizontal gene transfer.

15 ost infection and phage-dependent horizontal gene transfer.

16 ater efficiency for hematopoietic stem cells gene transfer.

17 s in host ecology, evolution, and horizontal gene transfer.

18 efficiently targeted on AML by DeltaNPM1 TCR gene transfer.

19 nown symbiont-host clades based on routes of gene transfer.

20 esents a unique model for natural horizontal gene transfer.

21 effect of changes in the code on horizontal gene transfer.

22 heir distribution across phyla by horizontal gene transfer.

23 oxysporum f. vasinfectum through horizontal gene transfer.

24 synthesis genes with bacteria via horizontal gene transfer.

25 nt cycles, and act as vectors for horizontal gene transfer.

26 fer and more effective than conventional TCR gene transfer.

27 sferase (gtr) operons acquired by horizontal gene transfer.

28 mplexity via gene duplication and horizontal gene transfer.

29 tion and completion of conjugative bacterial gene transfer.

30 motility, biofilm formation, and horizontal gene transfer.

31 tions for genetic engineering and horizontal gene transfer.

32 derms), an important mechanism of horizontal gene transfer.

33 MR mechanisms result from SNPs or horizontal gene transfer.

34 ant lineage following mutation or horizontal gene transfer.

35 immunity pairs that is shared via horizontal gene transfer.

36 eage III being the best donor for horizontal gene transfer.

37 gene loss, gene duplications, and horizontal gene transfer.

38 i-AAV antibodies and enabled efficient liver gene transfer.

39 nce genes (ARGs) may be shared by horizontal gene transfer.

40 resistance genes acquired through horizontal gene transfer.

41 es and often display hallmarks of horizontal gene transfer(10-12), the drivers of CRISPR disseminatio

42 mined assumptions about endosymbiont-to-host gene transfer [3-5].

43 Horizontal gene transfer accelerates bacterial adaptation to novel

44 genomics to improve our understanding of AMR gene transfer, adaptation and transmission to discover a

45 quisitions or losses and possibly horizontal gene transfer after the ancestral separation of the two

46 of foreign gene acquisition via a bacterial gene transfer agent and illustrate the major pathways of

47 Lysogenic-related and gene transfer agent-related genes are commonly found in

48 Gene transfer agents (GTAs) are descended from bacteriop

49 Gene transfer agents (GTAs) are thought to be ancient ba

50 Diverse prokaryotes produce gene transfer agents (GTAs), which are bacteriophage-lik

51 here are based on the 30-nanometer-diameter gene transfer agents of bacterium Rhodobacter capsulatus

52 Almost no proteins from RNA viruses or known gene transfer agents were detected, suggesting that they

53 thways, gene gains and losses, and horizonal gene transfer all contributed to the evolution of these

54 e-represents the first example of carotenoid gene transfer among vertebrates.

55 cens (PfmqsA) is acquired through horizontal gene transfer and binds to a slightly different motif [5

56 Frequent horizontal gene transfer and chromosomal integration events illustr

57 It represents one mode of horizontal gene transfer and contributes to the spread of traits li

58 enomes from other species through horizontal gene transfer and differential gene loss among genomes,

59 en receptor design, coupled with advances in gene transfer and gene-editing technologies, have enable

60 netic exchange mechanisms such as horizontal gene transfer and genetic recombination.

61 d virus type 2 (AAV2) are powerful tools for gene transfer and genome editing applications.

62 e sequence evolution, gene duplication-loss, gene transfer and multispecies coalescent processes.

63 comes, with implications for both horizontal gene transfer and rational strain design.

64 nstruction of species trees under horizontal gene transfer and recombination events.

65 le adaptation was associated with horizontal gene transfer and significant gene gain and loss.

66 The SB system enables high-level stable gene transfer and sustained transgene expression in mult

67 about both the evolutionary significance of gene transfer and the underlying molecular mechanisms, a

68 = 9) were interviewed prior to receiving the gene transfer and then at 3 and 12 months later.

69 However, poor efficiencies in gene transfer and undesirable safety profiles remain key

70 Adenovirus-based vectors are used today for gene transfer and vaccination.

71 es (HAdVs) are being explored as vectors for gene transfer and vaccination.

72 ther improvement of HAdV26-based vectors for gene transfer and vaccination.

73 importance of extracellular DNA, horizontal gene transfer and viruses for the generation of genetic

74 ovides a powerful means to identify Y-linked gene transfers and will help illuminate the evolutionary

75 16 events before the study to 1 event after gene transfer, and factor VIII use for participant-repor

76 and used to image tumor cells, cardiac viral gene transfer, and oncolytic virotherapy.

77 imaging, genetic mouse lines, viral-mediated gene transfer, and operant behavioral procedures, we mon

78 Natural transformation mediates horizontal gene transfer, and thereby promotes exchange of antibiot

79 ce and immunogenicity in AAV vector-mediated gene transfer are not fully understood, and effective so

80 al cross-kingdom interactions and horizontal gene transfer are proposed.

81 alysis indicates gene divergence and lateral gene transfer as equally important origins of these uniq

82 Despite all Y-linked gene transfers being evolutionarily recent (<1 million y

83 Plasmids are vehicles for horizontal gene transfer between bacteria, and in Neisseria gonorrh

84 Horizontal gene transfer between Gram-positive bacteria leads to a

85 The data suggest that horizontal gene transfer between vascular plants is not a rare even

86 proteins, demonstrating a role in horizontal gene transfer bolstered by broad-spectrum CRISPR-Cas9 in

87 ndependent of ARG acquisition via horizontal gene transfer but instead relied on antibiotic degradati

88 read of antibiotic resistance via horizontal gene transfer by natural transformation.

89 gregase homologs acquired through horizontal gene transfer by the species Pseudomonas aeruginosa and

90 wever, it is not clear whether supplementary gene transfer can rescue significant morphological chang

91 al 30 genus- and species-specific horizontal gene transfer candidates that might have contributed to

92 Furthermore, inferences of horizontal gene transfer connected viral lineages to diverse eukary

93 inition of gene gains and losses, horizontal gene transfers, conservation and evolutionary rate of se

94 that GH131-family expansions and horizontal-gene transfers contributed to this adaptation.

95 valuation and paw swelling compared with GFP gene transfer controls.

96 ne regulator were detected within 10 days of gene transfer, correlating with the presence of function

97 -Mini genome further implies that horizontal gene transfer could be an important driving force in the

98 er body weight rebound, suggesting that BChE gene transfer did not alter energy expenditure in the lo

99 ad of the mcr-1 gene by efficient horizontal gene transfer dominated by a limited number of plasmid i

100 This suggests, depending on in situ gene transfer dynamics, interactions with resident micro

101 This results in superior gene transfer efficacy in vitro and also in preclinical

102 ted intrathymically into wild-type mice, and gene transfer efficiency was monitored.

103 lay tropism for human hepatocytes, increased gene transfer efficiency, and neutralizing antibody evas

104 Vs) are relatively safe and demonstrate high gene transfer efficiency, low immunogenicity, stable lon

105 an potentially be applied to improve the AAV gene transfer efficiency.

106 stral cyanobacterial genes via endosymbiotic gene transfer (EGT), but most recent studies instead sup

107 genomes to reconstruct ancient endosymbiotic gene transfers (EGTs) and gene duplications.

108 atural genetic transformation via horizontal gene transfer enables rapid adaptation to dynamic enviro

109 e Cpt gene family suggests that a horizontal gene transfer event introduced this gene into an ancestr

110 have been involved in an ancient horizontal gene-transfer event.

111 were acquired through independent horizontal gene transfer events from different donor bacteria that

112 ota by engineering community-wide horizontal gene transfer events in situ.

113 We also detected putative horizontal gene transfer events in the genome of R. microporus.

114 logeny shows evidence of multiple horizontal gene transfer events within and between bacterial and eu

115 istory as a result of a series of horizontal gene transfer events, explaining the lack of geological

116 considerable number of potential horizontal gene transfer events.

117 that the range for virus-mediated horizontal gene transfer extends beyond hosts to nonhost cyanobacte

118 novel environments through single horizontal gene transfers (followed by regulatory adaptations), an

119 We attempted kidney-specific gene transfer following hydrodynamic tail vein injection

120 Despite the importance of horizontal gene transfer for rapid bacterial evolution, reliable as

121 ral feature format (GFF) or its descendants, gene transfer format (GTF) and GFF3.

122 features through a model generated from the gene transfer format file used during alignments reporti

123 is likely to have been obtained via lateral gene transfer from a prokaryote.

124 Nitrosotalea common ancestor via horizontal gene transfer from acidophilic representatives of Euryar

125 sembly, one of which was acquired by lateral gene transfer from Chlamydiae.

126 Our results provide evidence that horizontal gene transfer from Fusarium to Vd991 contributed signifi

127 that have likely been acquired by horizontal gene transfer from gram-positive bacteria.

128 Horizontal gene transfer from plants to microbes and between microb

129 dent endosymbiotic events accompanied by the gene transfer from the endosymbiont to host assembled a

130 We find horizontal gene transfers from bacteria and expansion of gene famil

131 on-coding DNA, chimeric fusions, and lateral gene transfers from other organisms [3-7].

132 es in gene content resulting from horizontal gene transfer, gene duplication and gene loss.

133 Although successful gene transfer has been reported in patients with hemophi

134 This mechanism of horizontal gene transfer has been widely linked to the acquisition

135 Gene transfer has long been a compelling yet elusive the

136 ent and transplantation, bioengineering, and gene transfer have proved successful in rescuing salivar

137 Acquisition of genes through horizontal gene transfer (HGT) allows microbes to rapidly gain new

138 tency to acquire exogenous DNA by horizontal gene transfer (HGT) and adapt them into its genome for s

139 Horizontal gene transfer (HGT) and gene loss result in rapid change

140 tment can mitigate this path, but horizontal gene transfer (HGT) between bacteria also occurs in such

141 Horizontal gene transfer (HGT) confers the rapid acquisition of nov

142 This particular type of horizontal gene transfer (HGT) could play a role in plant evolution

143 studies instead support multiple horizontal gene transfer (HGT) events to generate extant eukaryotic

144 ported to have elevated levels of horizontal gene transfer (HGT) events, but how important this is in

145 Horizontal gene transfer (HGT) facilitates spead of antibiotic resi

146 at AIG1 may have been acquired by horizontal gene transfer (HGT) from a rhizobial fungus.

147 elongatum has gained Fhb7 through horizontal gene transfer (HGT) from an endophytic Epichloe species.

148 y longer intergenic regions, post-horizontal gene transfer (HGT) gene fusions fostering coordinated e

149 Horizontal gene transfer (HGT) has been suggested to produce geneti

150 Horizontal gene transfer (HGT) has long been seen as a crucial proc

151 The role and extent of horizontal gene transfer (HGT) in eukaryotes are hotly disputed top

152 Horizontal gene transfer (HGT) is an important mechanism contributi

153 Although horizontal gene transfer (HGT) is common in angiosperm mitochondria

154 Horizontal gene transfer (HGT) is frequent in parasitic plant mitoc

155 While horizontal gene transfer (HGT) is well documented in bacteria, the

156 Horizontal gene transfer (HGT) is widespread in the evolution of pr

157 exchange genetic material through horizontal gene transfer (HGT) mediated by plasmids and plasmid-bor

158 Horizontal gene transfer (HGT) of mobile genetic elements (MGEs) fa

159 Horizontal gene transfer (HGT) plays an important role in bacterial

160 is lacking, with most studies of horizontal gene transfer (HGT) relying on bioinformatic analyses of

161 kleptoplast-targeted proteins via horizontal gene transfer (HGT) that are not derived from the klepto

162 oli through several mechanisms of horizontal gene transfer (HGT), including conjugation and cytoplasm

163 Horizontal gene transfer (HGT), the movement of genetic material ac

164 invading strain evolves by rapid horizontal gene transfer (HGT), which precedes and outweighs evolut

165 ar example of an ancient event of Horizontal Gene Transfer (HGT).

166 cquiring foreign DNA, also called horizontal gene transfer (HGT).

167 idrug-resistant pathogens through horizontal gene transfer (HGT).

168 omote bacterial evolution through horizontal gene transfer (HGT).

169 uses that have proven useful for therapeutic gene transfer; however, our understanding of host factor

170 ession of factor IX coagulant activity after gene transfer in 10 participants with hemophilia who rec

171 Methods enabling kidney-specific gene transfer in adult mice are needed to develop new th

172 enables transposon mediated-kidney specific gene transfer in adult mice.

173 IU per deciliter between weeks 2 and 9 after gene transfer in all seven participants, and the level i

174 eme environments, and the role of horizontal gene transfer in animal evolution.

175 A main mechanism of lateral gene transfer in bacteria is transformation, where cells

176 tion is a widespread mechanism of horizontal gene transfer in bacteria.

177 romosome) is a major mechanism of horizontal gene transfer in bacteria.

178 ssociated viral vector-mediated intrauterine gene transfer in early-gestation fetal macaques.

179 t possible to reconstruct this endosymbiotic gene transfer in laboratory experiments and study the me

180 n vivo was studied using adenovirus-mediated gene transfer in mice.

181 tion (NT) is a major mechanism of horizontal gene transfer in microbial species that promotes the spr

182 ly, this vector was used for interferon-beta gene transfer in mouse models of melanoma, resulting in

183 ntroduction as a TB drug, the development of gene transfer in mycobacteria enabled the discovery of t

184 ance of IncQ plasmids as agents of bacterial gene transfer in nature.

185 sion of monocytic cells results in long-term gene transfer in osteoclasts in the absence of haematopo

186 f plasmids, reveals the impact of horizontal gene transfer in rapidly generating new pathogenic linea

187 We also provide evidence for horizontal gene transfer in the mammalian gastrointestinal tract re

188 Adenovirus-mediated miR-101 gene transfer in the mouse lung attenuated bleomycin-ind

189 ology and biotechnology, enabling horizontal gene transfer in the wild and heterologous expression in

190 TCR gene-transfer in primary T cells resulted in specific pe

191 TCR gene transfer installed BOB1 specificity and reactivity

192 onditioning regimen and safety of lentiviral gene transfer into HSPCs.

193 The dynamics of gene transfer into recipient species was measured.

194 Gene gain by horizontal gene transfer is a major pathway of genome innovation in

195 Horizontal gene transfer is a means by which bacteria, archaea, and

196 Cationic lipid-mediated gene transfer is one of the most commonly used non-viral

197 cal Gli-dependent Hedgehog signaling by Gli1 gene transfer is sufficient to recover salivary function

198 TCR-gene-transfer is an efficient strategy to produce therap

199 sis, safety and efficacy of AAV-intrauterine gene transfer (IUGT) requires assessment.

200 Agrobacterium-mediated gene transfer leads to the formation of crown galls or h

201 maly had originally been ascribed to lateral gene transfer (LGT) from eukaryotes.

202 Evidence of eukaryote-to-eukaryote lateral gene transfer (LGT) has accumulated in recent years [1-1

203 aerales to investigate the impact of lateral gene transfer (LGT), gene duplication and loss across th

204 quire genes from the environment via lateral gene transfer (LGT).

205 binding proteins through putative horizontal gene transfer likely contributed to the origin of the ps

206 of iMecp2 provided widespread and efficient gene transfer maintaining physiological Mecp2 protein le

207 We also suggest that intracellular gene transfer may lead to extensive gene reshuffling and

208 s, 12-month-old Fabry mice were treated with gene transfer-mediated ERT or substrate reduction therap

209 Ex vivo gene transfer method, while efficient, requires addition

210 fi1 over-expression on HC regeneration using gene transfer methods in neonatal cochlear explants, and

211 Gene transfer of a plasmid expressing Cav-1 using transt

212 Adenoviral gene transfer of a single-chain IL-23 induces psoriatic

213 ion or an increased potential for horizontal gene transfer of ARGs in the biofilm.

214 These results demonstrate that gene transfer of Cav-1 downregulates inflammasome activi

215 d that electroporation-mediated transuterine gene transfer of Connexin30, utilizing a monophasic puls

216 Gene transfer of dominant negative mutant of BiP in the

217 Using dual viral-mediated gene transfer of DREADDs, we show that transient inactiv

218 nvestigated a novel approach of DNA-mediated gene transfer of HuMAbs that provide protection against

219 cancer immunotherapy has evolved from simple gene transfer of isolated TCRs to various affinity enhan

220 ethanotrophs, along with frequent horizontal gene transfer of mcr genes between alkanotrophs.

221 Gene transfer of murine TMZ-CD40L prolonged survival in

222 In contrast, SMC-specific gene transfer of Prkcd accelerated reendothelialization.

223 In vivo lineage tracing revealed that the gene transfer of SeV-GMT was more efficient than retrovi

224 Focal somatic gene transfer of TBX18 to the left ventricular apex in t

225 Gene transfer of TCRalphabeta heterodimers specific for

226 t, autophagy enhancement by means of hepatic gene transfer of the master regulator of autophagy trans

227 of antibiotic concentrations and horizontal gene transfer on risk; (2) compute total risk for sample

228 c innovations were facilitated by horizontal gene transfers on earlier phylogenetic branches, consist

229 uisition of new pathways, through horizontal gene transfer or genetic engineering, can have unpredict

230 issue GLO1 expression by adenovirus-mediated gene transfer or with the small-molecule inducer trans-r

231 Horizontal gene transfer permits rapid dissemination of genetic ele

232 .g. DNA fragments that facilitate horizontal gene transfer phenomena, were identified.

233 owards studying endosymbiotic and horizontal gene transfer processes, discusses the new knowledge gai

234 erate selection pressure and high horizontal gene transfer rate are necessary to generate genomic con

235 The gene transfer rate is significantly lower in Drosophila

236 as well as ecological drivers of horizontal gene transfer rates.

237 r strain, and recipient strain all influence gene transfer rates.

238 Lentiviral gene transfer represents a feasible pathway to glioma mo

239 natural selection, and pervasive horizontal gene transfer result in population admixture within skin

240 ring inter-species mating could limit future gene transfer, resulting in a role for CRISPR-Cas system

241 s) can spread among pathogens via horizontal gene transfer, resulting in imparities in their distribu

242 E1alpha-expressing BMPCs or direct IRE1alpha gene transfer significantly accelerated cutaneous wound

243 rough the obtaining of this GI by horizontal gene transfer, strain SQR9 not only acquired a competiti

244 , but there is current optimism for curative gene transfer strategies to induce expression of fetal h

245 es, thereby representing a highly attractive gene transfer strategy for clinical use.

246 The finding here alerts that gene transfer studies based primarily on 2D cultures sho

247 In ob/ob mice, EAT gene transfer suppresses body weight gain, maintains met

248 for diverse behaviors, including horizontal gene transfer, surface sensing, motility, and pathogenic

249 o Adeno-associated virus serotype 9-mediated gene transfer system, we confirmed in whole animal that

250 Specifically, an integrative approach of gene transfer, systems and brain slice electrophysiology

251 In addition, with the transuterine gene transfer technique utilized in our previous report,

252 Further advances in gene transfer technology, including the use of lentivira

253 ionary drivers of and barriers to horizontal gene transfer that are likely to structure pangenomes.

254 systems including their effect on horizontal gene transfer that can be either inhibitory or stimulato

255 Horizontal gene transfer through natural transformation is a major

256 lity of conventional gene vectors to achieve gene transfer throughout highly disseminated primary bra

257 ventional gene vectors to achieve widespread gene transfer throughout highly disseminated tumor areas

258 re is no consensus methodology for efficient gene transfer to adipose tissue and many studies report

259 we summarize the challenges associated with gene transfer to adipose tissue and report on innovation

260 ach and experimental workflow for validating gene transfer to adipose tissue.

261 fields, unlocking the impact of the lateral gene transfer to adjust the genome for extreme environme

262 We used viral-mediated gene transfer to block the transcription function of CRE

263 s rapidly evolve via mutation and horizontal gene transfer to counter evolving bacterial host defense

264 nome editing and transposon-mediated somatic gene transfer to demonstrate that expression of either t

265 Using viral-mediated gene transfer to express LINC00473 in adult mouse PFC ne

266 we and others have proposed vector-mediated gene transfer to generate long-term, systemic production

267 Specifically, we used IL-23 in vivo gene transfer to induce arthritis in mice and showed tha

268 application of viral- and non-viral-mediated gene transfer to liver, heart, skeletal muscle, and the

269 The horizontal gene transfer to loss ratio, but not duplication to loss

270 rrier, enter the brain, and enable efficient gene transfer to neurons.

271 t used adeno-associated virus (AAV)-mediated gene transfer to perform a low-throughput in vivo screen

272 , these bioinks supported enhanced non-viral gene transfer to stem cells in vitro.

273 mid (pMobErm51), or both enabling horizontal gene transfer to susceptible organisms and conferring hi

274 sids to facilitate efficient and noninvasive gene transfer to the central and peripheral nervous syst

275 ontrast, we found no evidence for functional gene transfer to the nucleus or loss of mitochondrial fu

276 e by foreign genes, functional mitochondrial gene transfer to the nucleus, and/or loss of mitochondri

277 Widespread gene transfer to the retina is challenging as it require

278 ing (NGS)-powered genomic scan, we show that gene transfers to the Y chromosome are much more common

279 Gene transfer using viral or nonviral vectors enables th

280 evalence gorilla adenovirus (GAd; GC46) as a gene transfer vector in mice.

281 istration of an adeno-associated virus (AAV) gene transfer vector significantly prevented pathology a

282 uman samples, only one has been studied as a gene transfer vector to date.

283 replication-deficient recombinant adenovirus gene transfer vector, for patients with high-grade (HG)

284 stably integrate genetic information through gene transfer vectors in a safe, effective, and economic

285 d by analyzing their properties as AAV/HBoV1 gene transfer vectors.

286 d viruses (AAVs) have proven to be effective gene transfer vectors.

287 tantly provides avenues to improve AAV/HBoV1 gene transfer vectors.

288 logy and suggest strategies to enhance HBoV1 gene transfer vectors.IMPORTANCE The family of Parvoviri

289 This horizontal gene transfer was mediated by a fraction of extracellula

290 Using viral-mediated gene transfer, we confirmed that MAALIN in the hippocamp

291 teriophage-mediated transduction to observed gene transfer, we found an inverse correlation between p

292 mal enzyme glucocerebrosidase for peripheral gene transfer, we found that alpha-Syn pathology is redu

293 Using viral-mediated gene transfer, we reveal that the hyper-induction of Rap

294 Using virus-mediated gene transfer, we show that drebrin overexpression in th

295 capsule synthesis island (cps) by horizontal gene transfer which consists of a synthetic locus and as

296 Using adenoviral gene transfer, wild-type and mutant SK2 channels were ov

297 After IL-23 gene transfer, wild-type mice exhibited concurrent skin

298 highly promising vehicles for liver-targeted gene transfer, with therapeutic efficacy demonstrated in

299 l transduced thymocyte subsets after in situ gene transfer, with transduction of up to 5% of cells.

300 ines the potential for EVs as a mechanism of gene transfer within heterogeneous microbial populations