ライフサイエンスコーパス: gene transfer

1 o the chromosomes of the host (endosymbiotic gene transfer).

2 ces its evolution by facilitating horizontal gene transfer.

3 oxysporum f. vasinfectum through horizontal gene transfer.

4 B receptor independent of age and time post gene transfer.

5 trains, indicating acquisition by horizontal gene transfer.

6 ins, with many likely acquired by horizontal gene transfer.

7 type specialization were acquired by lateral gene transfer.

8 but can also be acquired through horizontal gene transfer.

9 SBF transcription factor through horizontal gene transfer.

10 s but has never been reported via horizontal gene transfer.

11 l cellular differentiation during horizontal gene transfer.

12 suggesting their acquisitions via horizontal gene transfer.

13 rial mutation, recombination, and horizontal gene transfer.

14 mas and have been disseminated by horizontal gene transfer.

15 fragment by adeno-associated virus-mediated gene transfer.

16 inct virulence elements acquired via lateral gene transfer.

17 rial ancestors of plastids via endosymbiotic gene transfer.

18 gen fixation into cereal crops by direct nif gene transfer.

19 AAVs) are commonly used vehicles for in vivo gene transfer.

20 logical recording, calcium imaging and viral gene transfer.

21 tor, the latter possibly acquired by lateral gene transfer.

22 ily is consistent with widespread horizontal gene transfer.

23 synthesis genes with bacteria via horizontal gene transfer.

24 ment adversely affected basal activity after gene transfer.

25 change, producing time-dependent networks of gene transfer.

26 rich genetic material acquired by horizontal gene transfer.

27 ic archaea and bacteria may indicate lateral gene transfer.

28 umed that antibiotics can promote horizontal gene transfer.

29 he capacity for homoacetogenesis via lateral gene transfer.

30 ror correction in the presence of horizontal gene transfer.

31 ated viral vectors (serotype 2)-mediated NGF gene transfer.

32 nt cycles, and act as vectors for horizontal gene transfer.

33 fer and more effective than conventional TCR gene transfer.

34 effect of changes in the code on horizontal gene transfer.

35 sferase (gtr) operons acquired by horizontal gene transfer.

36 mplexity via gene duplication and horizontal gene transfer.

37 tion and completion of conjugative bacterial gene transfer.

38 motility, biofilm formation, and horizontal gene transfer.

39 tions for genetic engineering and horizontal gene transfer.

40 t become resistant by mutation or horizontal gene transfer.

41 d by one or both lineages through horizontal gene transfer.

42 heir distribution across phyla by horizontal gene transfer.

43 l conditions and by the action of horizontal gene transfer.

44 viruses (AAVs) are commonly used for in vivo gene transfer.

45 s including gene duplications and horizontal gene transfers.

46 a species known to undergo rapid horizontal gene transfer, 16.2% of isolate pairs considered noniden

47 mined assumptions about endosymbiont-to-host gene transfer [3-5].

48 Horizontal gene transfer accelerates bacterial adaptation to novel

49 In addition, four GTA (gene transfer agent) genes were identified in the DSS3Ph

50 Diverse prokaryotes produce gene transfer agents (GTAs), which are bacteriophage-lik

51 here are based on the 30-nanometer-diameter gene transfer agents of bacterium Rhodobacter capsulatus

52 Almost no proteins from RNA viruses or known gene transfer agents were detected, suggesting that they

53 grative and conjugative elements (ICEs), the gene-transfer agents (GTAs), and the staphylococcal path

54 ophora, a species previously intractable for gene transfer, although no clear evidence of transsynapt

55 upregulation of genes related to horizontal gene transfer and antibiotic resistance.

56 mmune biology, technological advancements of gene transfer and cell culture, and improved clinical in

57 of retinal diseases, coupled with growth of gene transfer and cell transplantation biotechnologies,

58 Gene transfer and expression of FADD sensitized resistan

59 Horizontal gene transfer and gene duplication allowed the stepwise

60 ly dynamic and involves extensive horizontal gene transfer and gene loss(1-4).

61 d virus type 2 (AAV2) are powerful tools for gene transfer and genome editing applications.

62 V) has become the vector of choice for viral gene transfer and has shown great promise in clinical tr

63 es modulate these impacts through mortality, gene transfer and metabolic reprogramming.

64 e sequence evolution, gene duplication-loss, gene transfer and multispecies coalescent processes.

65 els directly in NAc by use of viral-mediated gene transfer and observed an increase in depressive- an

66 The SB system enables high-level stable gene transfer and sustained transgene expression in mult

67 about both the evolutionary significance of gene transfer and the underlying molecular mechanisms, a

68 However, poor efficiencies in gene transfer and undesirable safety profiles remain key

69 de and evidence of recombination, horizontal gene transfer and variable fragment numbers.

70 ovides a powerful means to identify Y-linked gene transfers and will help illuminate the evolutionary

71 16 events before the study to 1 event after gene transfer, and factor VIII use for participant-repor

72 s on nutrient cycles, food web interactions, gene transfer, and other key processes in soils, very fe

73 o viruses, genetic isolation from horizontal gene transfer, and prevention of environmental escape by

74 Magnetofection, a non-viral gene transfer approach deploying magnetic nanoparticles

75 T8 by a highly efficient lentivirus-mediated gene transfer approach.

76 ce and immunogenicity in AAV vector-mediated gene transfer are not fully understood, and effective so

77 utionary forces underlie the rate of lateral gene transfer are not well understood.

78 vertheless, the tools for effective and safe gene transfer are now much improved, and we have started

79 -metazoan origin, indicating that horizontal gene transfers are frequent within this group and sugges

80 lly relevant animal model, support VEGF-B167 gene transfer as an affordable and effective new therapy

81 Despite all Y-linked gene transfers being evolutionarily recent (<1 million y

82 nal population structure in which horizontal gene transfer between different lineages is extremely ra

83 The data suggest that horizontal gene transfer between vascular plants is not a rare even

84 odes that differ in the extent of horizontal gene transfer by an order of magnitude.

85 gregase homologs acquired through horizontal gene transfer by the species Pseudomonas aeruginosa and

86 Additionally, resistance gene transfer can occur between Gram-negative species, r

87 Horizontal gene transfer can speed up adaptive evolution and suppor

88 f autoimmunity and curtailment of horizontal gene transfer caused by the defense systems and selfish

89 cytotoxicity of lentiviral-mediated ZF-Ldb1 gene transfer compared with the drug regimens support it

90 anding of chloroplast biology, intracellular gene transfer, conservation, diversity, and the genetic

91 inition of gene gains and losses, horizontal gene transfers, conservation and evolutionary rate of se

92 Recombination, reassortment and horizontal gene transfer constitute examples of pervasive biologica

93 Horizontal gene transfer contributes 3.5 % of the predicted genes,

94 valuation and paw swelling compared with GFP gene transfer controls.

95 Nrg4 gene transfer curbed HFD-induced hepatic steatosis by in

96 Successful gene transfer depends on a number of factors, of which t

97 er body weight rebound, suggesting that BChE gene transfer did not alter energy expenditure in the lo

98 Horizontal gene transfer disrupts the phylogenetic signal for some

99 Duplication, lateral gene transfer, domain fusion/fission and de novo domain

100 ad of the mcr-1 gene by efficient horizontal gene transfer dominated by a limited number of plasmid i

101 rgeted adeno-associated virus-mediated ETHE1 gene transfer dramatically improved both clinical course

102 Non-viral vectors are a preferred method of gene transfer due to potential safety and manufacturing

103 Endosymbiotic gene transfer (EGT) from the intracellular cyanobacteriu

104 he host nuclear genome through endosymbiotic gene transfer (EGT).

105 ge originated from a single large horizontal gene transfer event between CC23 and the hypervirulent C

106 ymes of animals originated from a horizontal gene transfer event in the stem lineage of Holozoa, i.e.

107 e Cpt gene family suggests that a horizontal gene transfer event introduced this gene into an ancestr

108 Horizontal and endosymbiotic gene transfer events have diversified oomycete metabolis

109 n to endosymbiotic gene transfer, horizontal gene transfer events occurring before, during, and after

110 istory as a result of a series of horizontal gene transfer events, explaining the lack of geological

111 , identify putative effectors and horizontal gene transfer events, map gene expression through the li

112 from gene loss, recombination and horizontal gene transfer events.

113 entifying mobile genetic elements or lateral gene transfer events.

114 nt the presence of multiple putative lateral gene transfer events.

115 es originating through functional horizontal gene transfer (fHGT) and speculated that fHGT was likely

116 We attempted kidney-specific gene transfer following hydrodynamic tail vein injection

117 mportant human pathogen, mediates horizontal gene transfer for the development of drug resistance, mo

118 SlopeTree corrects for horizontal gene transfer, for composition variation and low complex

119 ) was putatively acquired through horizontal gene transfer from a bacteriophage and is classified as

120 ve indicated their acquisition by horizontal gene transfer from a eukaryotic host.

121 ted by competent bacteria through horizontal gene transfer from a eukaryotic source, and later evolve

122 is likely to have been obtained via lateral gene transfer from a prokaryote.

123 Nitrosotalea common ancestor via horizontal gene transfer from acidophilic representatives of Euryar

124 ificaceae likely acquired HARP by horizontal gene transfer from an archaeon.

125 Twenty-four cases of horizontal gene transfer from bacterial sources were found in Picoc

126 n and insertion events as well as horizontal gene transfer from distant fungi.

127 them were likely acquired through horizontal gene transfer from extremophile bacteria which live in s

128 ing genes originally obtained via horizontal gene transfer from fungi and bacteria, contributed to th

129 Our results provide evidence that horizontal gene transfer from Fusarium to Vd991 contributed signifi

130 Horizontal gene transfer from plants to microbes and between microb

131 otation of hypothetical proteins highlighted gene transfers from non-pathogenic bacteria as a key fac

132 on-coding DNA, chimeric fusions, and lateral gene transfers from other organisms [3-7].

133 Our method efficiently models horizontal gene transfers, gene duplications and losses, and uses a

134 Although successful gene transfer has been reported in patients with hemophi

135 e to modulate population dynamics after such gene transfer has occurred, or both.

136 Gene transfer has rarely been tested in randomized clini

137 Numerous instances of lateral gene transfer have contributed to the complex and incong

138 Acquisition of genes through horizontal gene transfer (HGT) allows microbes to rapidly gain new

139 Horizontal gene transfer (HGT) among bacteria, archaea, and viruses

140 e importance of phages in driving horizontal gene transfer (HGT) among pathogenic bacteria, the under

141 genomic islands (GIs) involved in horizontal gene transfer (HGT) are the classical pathogenicity isla

142 Horizontal gene transfer (HGT) drives the evolution of recipient or

143 o RIP genes derived from a single Horizontal Gene Transfer (HGT) event, probably from a cyanobacteria

144 to CE1s of bacteria, suggesting a horizontal gene transfer (HGT) event.

145 ing genes through two independent horizontal gene transfer (HGT) events before the origin of land pla

146 ported to have elevated levels of horizontal gene transfer (HGT) events, but how important this is in

147 nd Branchiostoma) acquired GFP by horizontal gene transfer (HGT) from copepods or cnidarians or inher

148 ssumes without justification that horizontal gene transfer (HGT) in bdelloids precludes the sexual tr

149 ase provides putative genome-wide horizontal gene transfer (HGT) information for 2472 completely sequ

150 , represents a major mechanism of horizontal gene transfer (HGT) involved in the acquisition of virul

151 Horizontal gene transfer (HGT) is a major driving force of bacteria

152 Horizontal gene transfer (HGT) is the non-inherited acquisition of

153 Horizontal gene transfer (HGT) is the transfer of genetic material

154 Horizontal gene transfer (HGT) plays a major role in the spread of

155 them prone to viral predation and horizontal gene transfer (HGT) through transformation and conjugati

156 Evidence of horizontal gene transfer (HGT) was observed in four individuals coc

157 Horizontal gene transfer (HGT), or the transfer of genes between sp

158 ns by macrogenomic events such as horizontal gene transfer (HGT).

159 by bacteria capable of extensive horizontal gene transfer (HGT).

160 with only a few known examples of horizontal gene transfer (HGT).

161 The contribution of horizontal gene transfers (HGTs) from other bacteria to plastid est

162 In addition to endosymbiotic gene transfer, horizontal gene transfer events occurring

163 ession of factor IX coagulant activity after gene transfer in 10 participants with hemophilia who rec

164 te of the art requires sophisticated ex vivo gene transfer in a dedicated Good Manufacturing Practice

165 Methods enabling kidney-specific gene transfer in adult mice are needed to develop new th

166 enables transposon mediated-kidney specific gene transfer in adult mice.

167 IU per deciliter between weeks 2 and 9 after gene transfer in all seven participants, and the level i

168 eme environments, and the role of horizontal gene transfer in animal evolution.

169 Our work shows that horizontal gene transfer in bacteria can be promoted by bacterial h

170 ributes to attenuation of N13R10, markerless gene transfer in Escherichia coli was used to construct

171 ociated virus-based strategies for factor IX gene transfer in hemophilia B.

172 In vitro I-1c gene transfer in isolated left atrial myocytes from both

173 t possible to reconstruct this endosymbiotic gene transfer in laboratory experiments and study the me

174 ne transfer method, we demonstrate that Nrg4 gene transfer in mice suppressed the development of diet

175 n vivo was studied using adenovirus-mediated gene transfer in mice.

176 rates, and are also excellent candidates for gene transfer in organisms that have been refractory to

177 CRISPR-Cas provides a barrier to horizontal gene transfer in prokaryotes.

178 f plasmids, reveals the impact of horizontal gene transfer in rapidly generating new pathogenic linea

179 iew the main routes of antibiotic resistance gene transfer in S. aureus in the context of its biology

180 l impact of nucleus-to-nucleus endosymbiotic gene transfer in the evolution of complex algae, and the

181 We also provide evidence for horizontal gene transfer in the mammalian gastrointestinal tract re

182 Adenovirus-mediated miR-101 gene transfer in the mouse lung attenuated bleomycin-ind

183 e results demonstrate the role of horizontal gene transfer in the recent metabolic innovations expres

184 nrolled in this phase I trial of virus-based gene transfer in this mitochondrial disorder.

185 ultrasound-mediated enhancement of non-viral gene transfer in vivo.

186 ages that play important roles in horizontal gene transfer, in spread of antibiotic resistance genes,

187 AC6 gene transfer increased basal left ventricular peak -dP/

188 ell-based assays and in a mouse model of TCR gene transfer-induced graft-versus-host disease.

189 In this article, we report that IL-17A gene transfer induces epidermal hyperplasia in Il23r(-/-

190 TCR gene transfer installed BOB1 specificity and reactivity

191 ood by flow cytometry demonstrated exclusive gene transfer into CD4(+) human lymphocytes.

192 tial risk of antibiotic/herbicide-resistance gene transfer into neighboring plant species, endophytic

193 nor T cells on aGvHD induction by lentiviral gene transfer into primary T cells and using miR-181a/b-

194 The dynamics of gene transfer into recipient species was measured.

195 Horizontal gene transfer is a fundamental process in bacterial evol

196 Horizontal gene transfer is an important evolutionary mechanism for

197 Horizontal gene transfer is central to microbial evolution, because

198 Horizontal gene transfer is the primary driver in the diversificati

199 A particularly widespread mechanism of gene transfer is transformation.

200 Lateral gene transfer (LGT) from microbial symbionts to inverteb

201 roduction is unknown in the FOSC, horizontal gene transfer may contribute to the observed diversity i

202 f antibiotics to the promotion of horizontal gene transfer may have been overestimated.

203 the protease domain suggests that horizontal gene transfer may have occurred from a single-stranded R

204 We also suggest that intracellular gene transfer may lead to extensive gene reshuffling and

205 s, 12-month-old Fabry mice were treated with gene transfer-mediated ERT or substrate reduction therap

206 Using the hydrodynamic gene transfer method, we demonstrate that Nrg4 gene tran

207 Ex vivo gene transfer method, while efficient, requires addition

208 Correction of this abnormality by gene transfer might improve cardiac function.

209 n of ocular ACE2/Ang-(1-7)/Mas axis with AAV gene transfer modulates local immune responses and may b

210 SLPVs with algae, suggesting that horizontal gene transfer occurred between giant viruses and their p

211 provides robust evidence that rAAV-mediated gene transfer of a truncated CFTR functionally rescues t

212 Here, we investigate whether gene transfer of Ang-(1-9) is cardioprotective in a muri

213 sed therapy for cocaine abuse based on viral gene transfer of butyrylcholinesterase (BChE) mutated fo

214 sensitisation via systemic, cardiac-specific gene transfer of channelrhodopsin-2 (ChR2) was simulated

215 m WT mice after adeno-associated virus-based gene transfer of ChR2.

216 We used viral-mediated gene transfer of designer receptors (DREADDs) to activat

217 Viral gene transfer of full-length dystrophin could restore wi

218 The adenoviral gene transfer of human aquaporin-1 (hAQP1) water channel

219 elial cell (EC)-specific Atox1(-/-) mice and gene transfer of nuclear-target Atox1 in Atox1(-/-) mice

220 ntracoronary delivery of adenovirus-mediated gene transfer of recombinant human PDGF-BB upregulated m

221 ere must be pervasive and ongoing horizontal gene transfer of self-splicing introns into extant funga

222 In vivo lineage tracing revealed that the gene transfer of SeV-GMT was more efficient than retrovi

223 s a regulator of SERCA2a and have shown that gene transfer of SUMO-1 in rodents and large animal mode

224 Here we applied viral gene transfer of the acyl-ghrelin hydrolyzing enzyme, bu

225 t, autophagy enhancement by means of hepatic gene transfer of the master regulator of autophagy trans

226 the therapeutic potential of liver-directed gene transfer of these cytokines in a murine model of CH

227 Lentiviral gene transfer or knockdown of PPP1R11 in mouse lungs sig

228 ard by spontaneous mutagenesis or horizontal gene transfer, or because they can be circumvented by en

229 e in S. aureus can emerge through horizontal gene transfer originating from coagulase-negative staphy

230 as acquired from the host through horizontal gene transfer, perhaps facilitated by the long and intim

231 Horizontal gene transfer permits rapid dissemination of genetic ele

232 ymes and their paralogs, in which horizontal gene transfer played an important role.

233 Horizontal gene transfer (primarily conjugation) could explain this

234 owards studying endosymbiotic and horizontal gene transfer processes, discusses the new knowledge gai

235 cular expression of hAQP1 through adenoviral gene transfer promotes biliary BS output by modulating B

236 These findings show that the gene transfers provide an optimistic solution to the ins

237 The acquisition of genes by horizontal gene transfer provided new routes to handle toxins, for

238 oires of both have benefited from horizontal gene transfer, Pseudonocardia spp. have relied on plasmi

239 The gene transfer rate is significantly lower in Drosophila

240 r strain, and recipient strain all influence gene transfer rates.

241 as well as ecological drivers of horizontal gene transfer rates.

242 of chronic PH and evaluated the efficacy of gene transfer regarding progression of pulmonary vascula

243 sms by which antibiotics modulate horizontal gene transfer remain poorly understood.

244 ference of gene trees affected by horizontal gene transfer remains a largely unaddressed problem.

245 scence, by adeno-associated virus serotype 9 gene transfer, resulted in approximately 50% reduction o

246 AC6 gene transfer safely increased LV function beyond standa

247 rectly regulate the efficiency of horizontal gene transfer, serve as a selection force to modulate po

248 E1alpha-expressing BMPCs or direct IRE1alpha gene transfer significantly accelerated cutaneous wound

249 es, thereby representing a highly attractive gene transfer strategy for clinical use.

250 Gene transfer studies for the treatment of hemophilia be

251 CUPID 2 is the largest gene transfer study done in patients with heart failure

252 o Adeno-associated virus serotype 9-mediated gene transfer system, we confirmed in whole animal that

253 Specifically, an integrative approach of gene transfer, systems and brain slice electrophysiology

254 ilarly to unedited T cells redirected by TCR gene transfer (TCR transferred [TR]), SE T cells efficie

255 cell lineages, researchers are utilizing HSC gene transfer techniques using lineage-specific endogeno

256 d are amenable to patch clamp and adenoviral gene transfer techniques.

257 Gene transfer technology offers great promise as a poten

258 id rotifers is more likely due to horizontal gene transfer than to meiotic sex." This assumes without

259 lity of conventional gene vectors to achieve gene transfer throughout highly disseminated primary bra

260 odlets, in human tissue culture cells, after gene transfer to adult mice, and ex vivo in cell-free co

261 Using pharmacological methods and adenovirus gene transfer to bidirectionally regulate AMPK activity,

262 We used viral-mediated gene transfer to block the transcription function of CRE

263 Previous attempts using retroviral gene transfer to correct murine CD40L expression restore

264 nome editing and transposon-mediated somatic gene transfer to demonstrate that expression of either t

265 we and others have proposed vector-mediated gene transfer to generate long-term, systemic production

266 Specifically, we used IL-23 in vivo gene transfer to induce arthritis in mice and showed tha

267 The horizontal gene transfer to loss ratio, but not duplication to loss

268 this knowledge has been the establishment of gene transfer to provide continuing access to missing or

269 n murine models, VIPER facilitates effective gene transfer to solid tumors.

270 y in vivo by adeno-associated virus-mediated gene transfer to the brain of P301S-tg mice.

271 t that adeno-associated viral (AAV)-mediated gene transfer to the liver held great promise as a thera

272 nds over evolutionary time demonstrates that gene transfer to the nucleus was non-linear, that it occ

273 Widespread gene transfer to the retina is challenging as it require

274 Upon AAV8-RS1 gene transfer to the retina of adult XLRS mice, TRPM1 an

275 le-enhanced ultrasound can similarly improve gene transfer to the subventricular zone after intravent

276 has been used as an administration route for gene transfer to these cells.

277 ing (NGS)-powered genomic scan, we show that gene transfers to the Y chromosome are much more common

278 s, some of which were acquired by horizontal gene transfer, to manipulate host processes and promote

279 We developed a gene transfer tool for the control of nocturnal elevated

280 ext of the embryonic brain using an in utero gene transfer tool.

281 sive administration; and finally, the use of gene transfer using adeno-associated viral vectors to de

282 istration of an adeno-associated virus (AAV) gene transfer vector significantly prevented pathology a

283 replication-deficient recombinant adenovirus gene transfer vector, for patients with high-grade (HG)

284 y overcome limitations associated with viral gene transfer vectors and transient nonviral gene delive

285 We used novel targeted viral gene transfer vectors expressing redox-sensitive GFP fus

286 stably integrate genetic information through gene transfer vectors in a safe, effective, and economic

287 ourage the rapid introduction of more potent gene transfer vectors into early phase trials.

288 AB(vp) may be lost or acquired by horizontal gene transfer via transposition or homologous recombinat

289 sfer of CD11b(+)Gr-1(hi) cells, after IL-17A gene transfer, was sufficient to phenocopy the disease.

290 Now using the approach of in utero gene transfer we have discovered that Ulk4 plays a key m

291 capsule synthesis island (cps) by horizontal gene transfer which consists of a synthetic locus and as

292 nsgene silencing occurred in vector-mediated gene transfer, which were caused by the plasmid backbone

293 Gene transfer with a rAAV2/9 vector expressing Fkrp rest

294 catalytic domains originated via horizontal gene transfer with gut bacteria.

295 , expression of human kallistatin in lung by gene transfer with human kallistatin-encoding plasmid am

296 racteristically mosaic, driven by horizontal gene transfer with other phages and host genomes(5).

297 s of homologous recombination and horizontal gene transfer within 79 bacterial species.

298 he role of the oral resistome and horizontal gene transfer within and between commensals in the absen

299 ines the potential for EVs as a mechanism of gene transfer within heterogeneous microbial populations

300 on and ecology, underscoring that horizontal gene transfer without extensive regulatory changes can r