ライフサイエンスコーパス: general mechanism

1 served in diverse cancer types, suggesting a general mechanism.

2 ly similar across tasks, suggesting a domain-general mechanism.

3 ond Ago-binding platform, suggesting it is a general mechanism.

4 both sequestration and degradation may be a general mechanism.

5 CF-1 coordinated such differentiation by two general mechanisms.

6 o outstanding issues: (1) whether alpha is a general mechanism across sensory systems and (2) which c

7 The biomethods employed and their general mechanisms, advantages and limitations in releva

8 This general mechanism allows for development to be guided by

9 occal surface protein, which may represent a general mechanism among bacterial pathogens for activati

10 effect experiments confirm the hypothesized general mechanism and reveal the role of the phosphate c

11 ative aspect of network formation could be a general mechanism, and additional temporal regulators ma

12 Domain-general mechanisms are evolutionarily ancient, resulting

13 ized "core language network", whereas domain-general mechanisms are implemented in the bilateral "mul

14 together, our results indicate that FD is a general mechanism assisting in the local removal of TFs

15 This receptor-clamping approach might be a general mechanism-based strategy for engineering cytokin

16 Readthrough thus provides general mechanisms both to regulate gene expression and

17 for expression in Th17 cells, and suggest a general mechanism by which active STAT3 may be epigeneti

18 n of mixed-species communities and suggest a general mechanism by which bacteria could colonize hosts

19 ype of glutamate receptors and demonstrate a general mechanism by which Ca2+ -permeable AMPA receptor

20 vidual enhancers and promoters-may be a more general mechanism by which cells can regulate the access

21 Taken together, our results suggest a general mechanism by which CpG methylation can modulate

22 ion to relieve IRS1 inhibition may be a more general mechanism by which GPCRs act with the IGF-1R to

23 These results suggest a general mechanism by which Hsp90 can recognize and remod

24 tween the CNS and cellular immunity may be a general mechanism by which infectious agents exacerbate

25 ent findings on stellate cells, we propose a general mechanism by which mature inhibitory synapses ar

26 s is observed in human ES-MNs, pointing to a general mechanism by which neurons increase their repert

27 Thus modulation of inhibition may be a general mechanism by which oxytocin can act throughout t

28 ated endocannabinoid depletion by ABHD2 is a general mechanism by which progesterone exerts its genom

29 The results suggest a general mechanism by which SC factors may cooperate to r

30 ucing CD40-mediated p-P65 induction may be a general mechanism by which some current therapies modula

31 This model suggests a general mechanism by which TAG trafficking is coordinate

32 We thus reveal a general mechanism by which the core planar polarity path

33 ongation, described here for p21(CIP1), is a general mechanism by which transcription factor Sp3 fine

34 her transcription factors might constitute a general mechanism by which transcriptional auxin-sensiti

35 Collectively, these findings suggest a general mechanism by which Wnt signals shape synaptic co

36 udding yeast, but also provides insight into general mechanisms by which chromosomes organize sub-nuc

37 Despite remarkable advances, the general mechanisms by which the immune system differenti

38 This general mechanism can explain how PDI catalyzes oxidativ

39 tin silencing through cis variation may be a general mechanism contributing to evolutionary change.

40 transcription in activated DCs, we uncover a general mechanism counteracting low MHCI surface express

41 bolites that influence health through 1 of 3 general mechanisms: direct antimicrobial effects, enhanc

42 transcripts, suggesting its involvement in a general mechanism driving the RPi to RPo transition for

43 by nonnative interactions, which might be a general mechanism, e.g., in the recognition of histone t

44 tructured inhibition and excitation may be a general mechanism enabling sequence generation in other

45 econd mutations may constitute a more common general mechanism explaining phenotype variability.

46 eract during biogenesis, and may represent a general mechanism facilitating assembly of heteromeric p

47 between receptor helices H6 and H7 may be a general mechanism for active-state stabilization.

48 egulation of intrinsic excitability may be a general mechanism for adaptive control of behavioral out

49 aging are examined within the framework of a general mechanism for averaging of object rotation.

50 ork destabilization hypothesis as a unifying general mechanism for both SOD aggregation and ALS disea

51 extracellular Ca(2+) Our findings provide a general mechanism for Ca(2+) gating among different conn

52 catalysis with dienamine-catalysis as a new general mechanism for cascade reactions.

53 WD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positio

54 These findings demonstrate a simple and general mechanism for conferring temporal flexibility up

55 ration of key scaffolding proteins, may be a general mechanism for controlling the formation of RNA g

56 Trigger waves may be an important general mechanism for coordinating biochemical events ov

57 ctions between ER and GR and may represent a general mechanism for cross-talk between nuclear recepto

58 ions between multivalent proteins could be a general mechanism for cytoplasmic adaptor proteins to or

59 SUMO switch of FXR in obesity may serve as a general mechanism for diminished anti-inflammatory respo

60 fusion through gap junctions could provide a general mechanism for diverse cellular processes.

61 ocapsid shell are discussed in relation to a general mechanism for DNA-triggered procapsid expansion

62 We propose that fusion to GNA provides a general mechanism for dramatically enhancing the oral ac

63 We propose a general mechanism for efficient chemiluminescence in whi

64 This identifies PTGS as a general mechanism for eliminating highly abundant endoge

65 This is likely to be a general mechanism for enabling the wiring between these

66 representation is just one example of a more general mechanism for encoding continuous, task-relevant

67 egulatory regions of the same RPGs, a likely general mechanism for enhancer-promoter interactions.

68 We propose a general mechanism for environmentally-stimulated CNV and

69 We propose a general mechanism for epoxide selection by ionophore pol

70 These findings demonstrate a potentially general mechanism for exclusion of proteins from the Par

71 ns containing weakly interacting blocks is a general mechanism for forming regulated, membraneless or

72 These data provide a general mechanism for functional inactivation of ARF and

73 tifs targeted by distinct kinases provides a general mechanism for functional specialization of dupli

74 ormation with network states may represent a general mechanism for generating variability in behavior

75 The resulting model suggests a general mechanism for how nervous systems and excitable

76 Formation of secondary interfaces may be a general mechanism for increasing affinity and specificit

77 Distinct promoter types may be a general mechanism for increasing the regulatory capacity

78 initiated RNA Polymerase II (Pol II) is the general mechanism for inducing promoter-proximal pausing

79 lipid-specific binding domains, suggesting a general mechanism for interorganelle tethering.

80 ition of all known CN substrates, implying a general mechanism for KIF1Bbeta in Ca(2+) signaling and

81 This identifies a simple and general mechanism for learning-related regulation of mot

82 een strains and thus cannot be regarded as a general mechanism for light adaptation.

83 suggests that hyperexcited states provide a general mechanism for linking membrane electrical dynami

84 Our findings illustrate how a general mechanism for lysosome dispersal in nonneuronal

85 f distinct macrophage populations provides a general mechanism for macrophage expansion at key stages

86 We suggest that multiple Gli CRMs may be a general mechanism for mediating a robust transcriptional

87 Such multimodal regulations may be a general mechanism for metabolic modulation.

88 arly, suggesting that this study describes a general mechanism for Mga regulation of target virulence

89 d suggests that trace gas oxidation may be a general mechanism for microbial persistence.

90 These results support a general mechanism for nanoscale material degradation and

91 ether, these data present a more nuanced and general mechanism for nucleotide discrimination in which

92 nstrated this activity, suggesting this is a general mechanism for organizing and maintaining proper

93 Thus, Shot/Patronin ncMTOCs may provide a general mechanism for organizing noncentrosomal microtub

94 mechanotransduction by actin may serve as a general mechanism for organizing the cytoskeleton in res

95 counterpart of DsbA, allowing us to devise a general mechanism for oxidative folding that also reflec

96 Our findings provide a fundamental and general mechanism for oxygen-sensitive regulation of mit

97 Targeting sialic acids may be a general mechanism for pleiotropic actions of soluble klo

98 t sequential ITIM phosphorylation provides a general mechanism for precise temporal control over the

99 text, the model circuit presented provides a general mechanism for producing steering signals by comp

100 the authenticated target RRM1, suggesting a general mechanism for production of C terminus-truncated

101 Nucleotide-pool depletion could be a general mechanism for protecting cells from infectious a

102 suggest that induction of UCP2 may also be a general mechanism for protection of mitochondria during

103 the kinase activation T-loop may serve as a general mechanism for protein kinase down-regulation aft

104 on catalyzed by ICP8, which is most likely a general mechanism for protein-driven DNA annealing.

105 function through gene fusion appears to be a general mechanism for providing allostery for this enzym

106 comparison with Parkin and HHARI suggests a general mechanism for RBR E3 ligases.

107 Consistent with a general mechanism for reduction of lysosomal lipid accum

108 e that such nodes might act as features of a general mechanism for regulating cell-type-specific apop

109 ement during lncRNA transcription could be a general mechanism for regulating memory of previous even

110 f RF2 may occur on stop codons, suggesting a general mechanism for release-factor-mediated translatio

111 annel to the plasma membrane may represent a general mechanism for restoring phagosome activity in co

112 cell lines with Rnd3 knockdown, suggesting a general mechanism for Rnd3-mediated PKA signaling activa

113 shes positional information thus providing a general mechanism for rostro-caudal patterning of the ec

114 ide is pH-independent, there could be a more general mechanism for sensitization of AE2-depleted chol

115 ugh segregation of inhibition, a potentially general mechanism for sequential motor patterns.

116 ng that mediates PSG formation and in a more general mechanism for signaling carbon source exhaustion

117 le regulators such as CDKG1 is a potentially general mechanism for size control.

118 Here, we suggest a general mechanism for slow relaxations and aging, which

119 activation of Cdc42 or Rac GTPases may be a general mechanism for spatial cue-directed cell polariza

120 band-pass mechanical filter, and provides a general mechanism for symmetrical and rapidly adapting M

121 identical mechanisms of action, suggesting a general mechanism for targeting this group of TLRs.

122 Our results support a general mechanism for the activation of mGluRs in which

123 s are widespread in cortex and may provide a general mechanism for the control of motor decisions by

124 Our approach provides a parsimonious and general mechanism for the emergence of critical-like beh

125 Our study provides a novel general mechanism for the evolution of diversity that ma

126 A general mechanism for the formation of a beta-lactam ant

127 es in these isolates suggests that this is a general mechanism for the formation of miniature inserti

128 This suggests a general mechanism for the generation and stabilization o

129 folding through parallel pathways might be a general mechanism for the large two-domain proteins that

130 to vaginal challenge could be a potentially general mechanism for the mucosal immune system to sense

131 We hypothesize this is a general mechanism for the participation of myosin XI and

132 l properties as well as provides access to a general mechanism for the real-time tracking of supramol

133 x DNA-mediated reduction is established as a general mechanism for the reduction of distally bound st

134 suggest that interfacial geometry triggers a general mechanism for the regulation of cancer-cell stat

135 cription factors by external cues could be a general mechanism for the regulation of cell growth by e

136 aryls, heteroaryls, and dienes, as well as a general mechanism for the selective transfer of ligands

137 imental and modeling approaches, we reveal a general mechanism for the spatial spread of subtle cellu

138 is is significant, because it demonstrates a general mechanism for the targeting of the RIG-I pathway

139 This may also represent a general mechanism for the targeting of TM proteins to ra

140 etween Brd4 and Hsp90 in ADPKD may also be a general mechanism for the upregulation of Brd4 in cancer

141 Fusion of cellular factors may represent a general mechanism for their asymmetric segregation at di

142 on and specific cell functions may provide a general mechanism for their coordination in time and spa

143 carbon-use efficiency provides a potentially general mechanism for thermal adaptation in phytoplankto

144 extrusion during palate fusion and suggest a general mechanism for tissue fusion in development.

145 pport ATP-driven backward translocation as a general mechanism for transcriptional regulation.

146 SS selection by bacterial RNAP and suggest a general mechanism for TSS selection by bacterial, archae

147 ng is a particularly important set of domain-general mechanisms for constructing human groups - enabl

148 signaling modify neural networks and suggest general mechanisms for generating flexible behavioral ou

149 We identify several general mechanisms for how population ecology phenomena

150 on and homologous recombination might be the general mechanisms for local genome region expansion.

151 rol literature, suggesting that there may be general mechanisms for pest control and that biocontrol

152 nteraction and trans self-association may be general mechanisms for regulation of RNA helicase functi

153 ation of higher order polymers is one of the general mechanisms for signaling platform assembly in in

154 Our studies illuminate general mechanisms for substrate recognition and catalys

155 We propose general mechanisms for the broad-spectrum inhibition Abe

156 Several general mechanisms for toxin function have been establis

157 for the PcrA 3'-5' helicase and so may be a general mechanism governing superfamily 1 helicases.

158 e biological distinctions among species, but general mechanisms have been elusive.

159 Multiple general mechanisms have been found to directly contribut

160 Two general mechanisms have been suggested for the temporal

161 Developmental plasticity and domain-general mechanisms have important consequences with resp

162 Our results suggest a general mechanism how nucleosomes increase transcription

163 antly related helicases Rho and E1 reveals a general mechanism in homomeric ATPases whereby complex a

164 Our study proposes a general mechanism in regulating lineage segregation duri

165 e collapse of transfusion tracheids may be a general mechanism in this group for the protection of le

166 Moreover, our simulations support a general mechanism in which membrane proteins laterally d

167 This suggests a general mechanism in which the visual system assesses th

168 Two lines of evidence support a general mechanism in which W515 at the intracellular jux

169 hat RF B cells break tolerance with the same general mechanisms in the TC and the MRL/lpr lupus-prone

170 We describe three general mechanisms, including targeted proteolysis of si

171 erential stabilization of R-loops could be a general mechanism influencing gene expression in many or

172 al regulation is solidly established and the general mechanisms involved in this type of regulation a

173 This general mechanism is also conserved by natural cysteine-

174 A general mechanism is proposed for transition metal-catal

175 in binding sites but rather, through a more general mechanism, largely mediated through dissociation

176 efect mobility in SP-CSAs is identified as a general mechanism leading to slower growth of large defe

177 soil C input alone, indicating that it is a general mechanism limiting C accumulation in soil.

178 ports the hypothesis that harshness may be a general mechanism limiting local diversity and explainin

179 This general mechanism may extend to other receptors that rel

180 This general mechanism may have rendered the evolutionary dyn

181 We study this general mechanism of "collective guidance" computational

182 found for transferrin receptor, suggesting a general mechanism of action.

183 ion suggests conformational selection as the general mechanism of allostery in this canonical signall

184 Such preferential coupling may represent a general mechanism of ANO1 activation in native tissues.

185 the N termini and sheds light on a potential general mechanism of channel and receptor activation.

186 velopment of the VWFA, possibly reflecting a general mechanism of cortical development.

187 either light or cellular reductants may be a general mechanism of CRY activation.

188 n complex to derive specific details and the general mechanism of CTS binding and inhibition.

189 In addition, there is growing support for a general mechanism of DNA-membrane contacts based on tran

190 While the general mechanism of ecdysone-dependent transcription is

191 nes is an evolutionary novelty of flies or a general mechanism of embryonic morphogenesis.

192 RIIB signaling components, thus supporting a general mechanism of FcgammaRIIB cross-linking in vivo f

193 These results reveal a general mechanism of HIV-1 neutralization by MPER-specif

194 he membrane, our results point toward a more general mechanism of how active transport can be modifie

195 These data may represent a general mechanism of humoral response-mediated protectio

196 iophysical phenomena and its importance as a general mechanism of hydrophobic self-assembly.

197 re rich in PG, so these data point to a more general mechanism of immune detection of infection- or s

198 Our work highlights a general mechanism of kinesin inhibition in which small-m

199 To understand the general mechanism of macrolide action, we used genome-wi

200 These results support a general mechanism of Na(+) current inhibition that is wi

201 rved for the imidazoles as expected from the general mechanism of oxidative ring openings of imidazol

202 However, a general mechanism of PFA has remained elusive.

203 y useful to further the understanding of the general mechanism of pol beta while providing context to

204 epression of multiple alternative fates as a general mechanism of repressor action.

205 important in mammals and yeast, and may be a general mechanism of restoring small linear chromosome n

206 We now report a third general mechanism of riboswitch action: governing the ab

207 edge of its basis has allowed us to unveil a general mechanism of selective vapor response observed i

208 e results indicate that phase alignment is a general mechanism of the brain to process rhythmic struc

209 Although the general mechanism of the NER process is well studied, th

210 gest that multiplexed population coding is a general mechanism of touch encoding common to species as

211 in-induced unfolding is a key element in the general mechanism of toxin inactivation by human defensi

212 is rapid, and regulated proteolysis may be a general mechanism of transducing surface stimuli.

213 he results reveal a previously unappreciated general mechanism of translational quality control, in w

214 om these studies provides new insight into a general mechanism of triplet-repeat expansion in iPSCs.

215 de a platform for the integration of primate-general mechanisms of acoustic communication with the fa

216 mmune disease, although the exact origin and general mechanisms of action have remained to be elucida

217 review paper, we provide an overview of the general mechanisms of cardiac fibrosis in AF, difference

218 This finding led us to propose general mechanisms of dependency on plastid organelles i

219 findings allow us to formulate and quantify general mechanisms of genetic suppression.

220 delivery from the gut to tissues, as well as general mechanisms of metabolism of ingested sialic acid

221 These findings may provide insight into general mechanisms of psychiatric illness.

222 es and will further our understanding of the general mechanisms of rotary molecular motors.

223 Not only do these data provide insight into general mechanisms of signal transduction, but also they

224 esign, similarities among taxa can elucidate general mechanisms of the process whereas differences ma

225 identified so far, as well as their basis in general mechanisms of vascular development and stability

226 , plaque size, viral and host functions, and general mechanisms of virus propagation.

227 lope relatively robust in reverberation: one general mechanism operating for all stimuli with small m

228 Our results suggest a general mechanism operative in plants in which BR-mediat

229 at all sites influence signaling by the same general mechanism, presumably through changes in packing

230 ture and provide new syntheses for how these general mechanisms produce novel insights on five major

231 Similar heterogeneity tradeoffs might be a general mechanism promoting phenotypic variation in any

232 n during the onset of XCI and functions as a general mechanism regulating chromatin configuration in

233 o explain growth differences among families, general mechanisms seem also to be involved, and thus, r

234 Our findings support a general mechanism: sequential binding of DREAM, MMB and

235 This general mechanism should help explain the NPL in organis

236 In principle, the brain could have evolved a general mechanism that applies the same learning rule to

237 ted capture of similar inhibitors might be a general mechanism that could be applied to other synthet

238 and celiac disease, these results suggest a general mechanism that could contribute to immune-mediat

239 We propose a novel, simple but general mechanism that could give rise to hormesis in sy

240 We predict that this is a general mechanism that detaches myosin V from select car

241 This may be a general mechanism that drives other IL-6-producing malig

242 We propose a general mechanism that enables the fine-tuning of the Fe

243 The results are interpreted in terms of a general mechanism that features formation of an iso-trib

244 Vesicular transport is a general mechanism that governs intracellular membrane tr

245 s suggest low-frequency phase to be a domain-general mechanism that orchestrates dynamic memory repla

246 ely, effects of reward may be part of a more general mechanism that prioritizes the processing of any

247 pretation, these results reveal an important general mechanism that regulates the activity and substr

248 both language-specific mechanisms and domain-general mechanisms that are engaged in many cognitive pr

249 ted proteins, little is known regarding more general mechanisms that contribute to the generation of

250 ies of specific complexes and in elucidating general mechanisms that explain how quaternary structure

251 Here, we review the general mechanisms that regulate organ growth, describe

252 Thus, electrical coupling may provide a general mechanism to achieve near-optimal information tr

253 A general mechanism to address the conflict between streng

254 gher-order protein self-association may be a general mechanism to concentrate functional components i

255 ediated inflammatory pathway may represent a general mechanism to control inflammation in inflammator

256 Proenzyme maturation is a general mechanism to control the activation of enzymes.

257 nd E2F3 by miR-200 family members might be a general mechanism to control the transition from a pluri

258 th specific regulatory factors may provide a general mechanism to diversify the functional repertoire

259 tions at other transport steps may provide a general mechanism to drive lipid bilayer merger.

260 is 'tag-team proofreading' represents a more general mechanism to ensure a specific set of proteins i

261 ng regulatory kinases to replisomes may be a general mechanism to ensure spatial and temporal coordin

262 at the packaging of p-RTKs in endosomes is a general mechanism to ensure the fidelity and specificity

263 The results suggest that EVs may be a general mechanism to exchange non-specialized genetic ca

264 This repartitioning could represent a general mechanism to explain changes in product release

265 on factor on rates via clustering provides a general mechanism to facilitate binding to low-affinity

266 roup stabilizes the 4HB stalk as part of the general mechanism to fine-tune F-activation.

267 nce, we propose that filament formation is a general mechanism to inactivate and store key metabolic

268 ubiquitously expressed, this may represent a general mechanism to induce apoptosis in a variety of im

269 The phosphoswitch provides a general mechanism to integrate diverse stimuli to regula

270 ophagy at centriolar satellites represents a general mechanism to promote ciliogenesis in mammalian c

271 its occurrence, and propose that it may be a general mechanism to promote zero-lag synchrony in the b

272 h coherent phase-amplitude coupling may be a general mechanism to regulate neuronal interactions alon

273 tional modification of cryptic residues is a general mechanism to regulate tissue elasticity.

274 Thus, phosphorylation of SNARE domains is a general mechanism to restrict how much cells secrete, op

275 that protein poly(ADP-ribosyl)ation may be a general mechanism to target proteins for ubiquitination.

276 on-associated suicide, which may represent a general mechanism to transiently limit self-destruction

277 ng to a single coat protein might serve as a general mechanism to trigger efficient capture, or may b

278 or universal prosociality, and that the same general mechanisms underlie both religious and secular e

279 This may not only provide a general mechanism underlying BRCA1's function in maintai

280 suggest that the novel PC site is part of a general mechanism underlying proenzyme maturation of ADA

281 uitment of vesicular thermoTRP channels is a general mechanism underlying sensitization of all nocice

282 ropose that reactivations during sleep are a general mechanism underlying the abstraction of temporal

283 ressor transcription factors may represent a general mechanism underlying the cooperativity of oncoge

284 chromatin factors in specific contexts, or a general mechanism underlying the establishment of chroma

285 Such gating might be a general mechanism underlying the rhythmic nature of huma

286 temperature mediated oxygen limitation is a general mechanism underlying the thermal tolerance of em

287 tter volume may be due to alterations in the general mechanisms underlying normal brain development i

288 charged drugs and may also hint toward more general mechanisms underlying the induction of autoantib

289 ion networks of the brain, suggesting domain-general mechanisms underlying the representation of cons

290 We discuss two general mechanisms underlying the weak influence of this

291 naling, suggesting that lncRNA-rSBE may be a general mechanism used by cells to fine-tune Smad3 activ

292 Kinetic gating may be a general mechanism used by site-specific DNA-binding prot

293 Our data suggest a general mechanism used by tumor cells to breach the base

294 These findings support a general mechanism where DNA glycosylases use highly dyna

295 This supports a general mechanism where localized actin polymerization c

296 lts provide a novel example of a potentially general mechanism whereby climate change-mediated range

297 ed proteasome substrates thus far revealed a general mechanism whereby the exposure of cryptic hydrop

298 antitoxin can therefore provide insight into general mechanisms whereby protein disorder regulates ev

299 This general mechanism, which we call "segregation lift," req

300 discuss the most popular theories regarding general mechanisms widely believed to underlie hedonic d