ライフサイエンスコーパス: general model

1 nt was associated with SCD risk (P=0.008 for general model).

2 b-models also are precisely predicted by the general model.

3 rate models are suggested as steps toward a general model.

4 p of sequences, leading to an insufficiently general model.

5 better linearity than is obtained in a less general model.

6 tability estimates were lower using the more general model.

7 onsumer-resource models are derived from the general model.

8 simulations confirmed these findings for the general models.

9 rimental detail leads to the construction of general models.

10 nhibit enterotoxin activity may lead to more general models about toxin activity or entry into cells

11 The general model accommodates data from acorn woodpeckers a

12 minally associated with type 2 diabetes in a general model (additive P = 0.03, dominant P = 0.005) bu

13 Articulating these states into a general model allows for dissecting, comparing, and deri

14 We describe these both in terms of general modelling and addressing the specific conditions

15 This general modeling approach is potentially applicable to o

16 able to other locations (transferability) or general models are applicable to smaller areas (generali

17 rivations of the analyses, carried out for a general model, are provided in an Appendix.

18 This paradigm may offer a general model as to how tissue-specific regulatory mecha

19 trait variation and partitioning suggested a general model based on four interconnected findings.

20 Here we derive a general model, based on first principles of allometry an

21 We derive a general model, based on principles of biochemical kineti

22 t-output mapping for training stimuli, and a general model-based strategy that utilizes humans' defau

23 We also developed a general, model-based approach to gauge the effects of fa

24 ration effect could yet be predicted using a general model built on refined wheat (adjusted R2: 0.998

25 Here we develop a general model by combining memory effect and population-

26 We outline a general model by which corepressors and coactivators reg

27 These results suggest a general model by which differential adhesion can be util

28 ned with data from the martian meteorites, a general model can be constructed that constrains the his

29 There are currently two general models competing to explain the role of subjecti

30 sis of carbon-leaving group (C-LG) bonds, no general models connect structure to reactivity for heter

31 Three general models connect these patterns to anatomical evol

32 oaches have remained disconnected because no general models currently provide a means of directly com

33 We exhibit two examples of this general model describing assembly of dodecahedral and ic

34 A previous general model describing physical constraints on gamete

35 teria or insecticides) performed better than general models developed on all data.

36 The resulting general model enables interpreting each phase of the dos

37 We examine the identifiability of a general model encompassing three such mechanisms: popula

38 These results suggest a general model explaining how ATP hydrolysis is coupled t

39 Based on these data, we propose a general model explaining how expression of the MMO opero

40 own has a negligible effect, demonstrating a general model finding that varying the expression levels

41 This Viewpoint outlines this general model, focusing on the specific example of Arabi

42 We specify this general model for 11 generic consumer strategies that gr

43 first set a stochastic equation system as a general model for a heterogeneous quorum sensing network

44 The data support the general model for ABC transporters in which the NBDs for

45 mechanism in striatal neurons and suggest a general model for achieving rapid posttranslational subu

46 id leukemia (AML) in mice is often used as a general model for AML.

47 e in APP regulation and may determine a more general model for amyloid generation as seen in AD.

48 In this paper we present a general model for an information management system that

49 me of Wynberg's reaction and provides a new, general model for asymmetric cinchona organocatalysis.

50 These results suggest a general model for auxin signalling in which the modulati

51 Our discoveries suggest a general model for bacterial pathogens in which mutations

52 We also propose a general model for birth-order-dependent neural specifica

53 Based on our results, we propose a general model for branching during maize inflorescence d

54 alleles of low frequency may serve as a more general model for complex genetic diseases, posing a sig

55 These results suggest a general model for control of SCF activities.

56 X-ray diffraction data support a general model for crustaceans in which tails associate t

57 Herein we develop a rigorous and general model for defect formation in the presence of st

58 refore suggest an alternative to the current general model for DNA unwinding by hexameric helicases.

59 s of nuclear organization, contributing to a general model for enhancer function that involves direct

60 sistance with measured values, and provide a general model for examining the diversity gill morpholog

61 sphate pools, and from DNA, and we suggest a general model for excluding purine base analogs from DNA

62 A general model for FGF- and heparin-induced FGFR dimeriza

63 sm described in HIV-1 PR is proposed to be a general model for flap closing in retroviral aspartic pr

64 We present a general model for fluorescence quenching by hydrogen don

65 , genes, and gene expression, and provides a general model for gene evolution following whole-genome

66 Our findings allow us to formulate a general model for generation of periodic pattern in the

67 termediates are generated and may serve as a general model for highly processive travelling machines

68 lycan binding region of EBLs, and suggests a general model for how DBL domains evolve under dual sele

69 d an anti-ligase function in Emi1 suggests a general model for how E3 substrates evolve to become pse

70 Based on these findings, we propose a general model for how Hsp104 and related chaperones oper

71 nges in synaptic efficacy and may serve as a general model for how surface receptor number is establi

72 Our method is appropriate under a very general model for how the site influences the trait, inc

73 We present here a general model for integrase family site-specific recombi

74 The conversion serves as a general model for integration of multiple pathway resour

75 s interactions with lipid micelles provide a general model for interactions between TSPs, membranes,

76 stitutive transcriptional activator may be a general model for its oncogenic conversion in myeloid le

77 onformational changes in KirBac1.1 provide a general model for ligand-induced Kir channel gating at t

78 We propose a general model for Ni(2+) recognition in which betaHis81

79 This study provides a general model for niche-induced fate determination in ad

80 These findings suggest a general model for oncogenic complicon formation.

81 Based on these findings, we propose a general model for oncogenic mutants of p85 and p110 in w

82 We suggest a general model for paramyxovirus fusion activation in whi

83 We suggest a general model for paramyxovirus fusion activation in whi

84 yeast RFC-PCNA complex, thereby presenting a general model for PCNA loading by RFC in archaea and euk

85 s drawn from disturbance ecology to create a general model for population dynamics in disturbance-pro

86 These findings suggest a general model for predicting the susceptibility of prote

87 of whether it is unique to humans or a more general model for primate vision.

88 se findings provide a structural basis and a general model for product specificity in PRMTs, which wi

89 A general model for protein degradation by the MPC is disc

90 s tandem BRCT domains and that this may be a general model for protein-protein interactions between D

91 n gels at the subpicomole level represents a general model for proteome studies relating genomic sequ

92 e we establish and experimentally validate a general model for Rayleigh scattering in FMFs.

93 ate at different residues and also suggest a general model for regulation of PRMTs.

94 orded from the rodent hippocampus suggests a general model for remembering episodes.

95 These findings lead to a general model for Rho binding and translocation and esta

96 Here we develop a general model for shell growth based entirely on the loc

97 We propose that this provides a general model for Smad4/MEDEA function in signaling by t

98 The structure leads to a general model for specific ribosome recognition by amino

99 ses Igk germline transcription and provide a general model for STAT5-mediated epigenetic transcriptio

100 has recently established this organism as a general model for studying cytokinesis.

101 To provide a general model for studying the role of oligopeptide repe

102 om Bacteroides thetaiotaomicron and derive a general model for substrate translocation.

103 Beyond the AOB, this study presents a general model for synchronous infra-slow bursting in neu

104 The proposed mechanism may provide a general model for the antisickling effects of aldehyde c

105 ight-chain variable domains is proposed as a general model for the assembly of protein fibrils.

106 genetic relationships, leading to a revised general model for the biosynthesis of these virulence-co

107 production of IL-7 by thymic stroma may be a general model for the clinically observed adverse effect

108 Our results suggest a general model for the conformational switch in the cycli

109 We present a general model for the Continuous Prisoner's Dilemma and

110 train divergence and evolution, as well as a general model for the discovery of functional mutations

111 It may also suggest a general model for the evolutionary flexibility of conser

112 ly mammalian development and could provide a general model for the genomic response to acquisition of

113 CaM-Na(V)1.5 IQ motif complex can serve as a general model for the interaction between CaM and ion ch

114 The suppressors outline a general model for the mechanism of suppression of the G6

115 These and other results further support a general model for the membrane specificity of the C2 dom

116 s of YAP2-type uORFs and also support a more general model for the mode of action of other known uORF

117 ve been subject to intense investigation, no general model for the molecular basis of nonadditive gen

118 stages of the infection is considered, and a general model for the pathogenesis of urinary tract infe

119 We present a general model for the Prisoner's Dilemma in which variab

120 es of mutated EGFR-CD45 chimeras supported a general model for the regulation of RPTPs, derived from

121 We propose a general model for the requirement of host RNA polymerase

122 We now propose a general model for the role of Aha1 in the Hsp90 ATPase c

123 for other mammalian OBP-ligand complexes, a general model for the role of OBPs in mammalian olfactio

124 ther DNA processing pathways, and proposes a general model for the role of RPA in protein-mediated ha

125 This requirement leads to a general model for the spreading and inheritance of silen

126 Our results provide a general model for the stepwise process leading to genome

127 These results lead to a general model for the synergistic function of activation

128 )-DNA cleavable complex, we have developed a general model for the ternary drug-DNA-TOP1 cleavable co

129 tify four additional TTN genes and present a general model for the titan phenotype.

130 This approach may serve as a general model for the undertaking of population-specific

131 nd nociceptors expressing TRPM8, providing a general model for this form of cold-induced pain.

132 In the general model for transcription-coupled DNA repair, an R

133 role for the CY of FcgammaRIa and provide a general model for understanding how multiple receptors t

134 We present a general model for understanding the stereochemical cours

135 We develop and test a general model for variation within and between species i

136 Finally, we describe a general model for VNTR mutations that encompasses insert

137 ain structures has allowed us to formulate a general model for why most L27 domains form an obligate

138 To test general models for membrane-protein folding and to ident

139 ndividuals in the same analysis and to allow general models for the crossover process to incorporate

140 We present general models for the relationship between enhanced fus

141 A general model framework is presented here but a special

142 To overcome this limitation, we develop a general modeling framework to shed light on the relative

143 We present and analyse a general modelling framework for systems where breeders a

144 We shall discuss a more general modelling framework of interactions of structure

145 ell firing in the AcbSh is consistent with a general model from other pharmacological and electrophys

146 Then, defining a rather general model Hamiltonian for the donor material, we sho

147 A general model has been proposed for the fusion mechanism

148 Two general models have been proposed for DNA replication.

149 Earlier general models have investigated when environmental pred

150 In this paper we provide evidence that a general model in the network science on opinion dynamics

151 ther membrane protein complexes has led to a general model in which a unique, ordered pathway is foll

152 These data suggest a general model in which convergent maps use coincident ac

153 1 restriction in T cells, and they suggest a general model in which multiple APOBEC3 proteins functio

154 ucleic acids, a hypothesis consistent with a general model in which some modern biochemical systems r

155 It allows the formulation of a more general model in which stable PRD can be induced by a va

156 ibition and open probability, supporting the general model in which the bi-lobe motion in ATD regulat

157 ses of both cell types can be described by a general model in which the outputs of a set of linear fi

158 ation in cellular extracts and in terms of a general model in which VHR may be a general MAP kinase p

159 By comparison with a general model, in which transmission probabilities and r

160 For a general model incorporating the role of succession or pa

161 account for these observations, we propose a general model incorporating unique opportunities for mei

162 We develop a general model incorporating viral dynamics and pharmacok

163 We use a general model, incorporating biological components and d

164 or experimental systems, incorporated into a general model, indicate that oncogenic stimuli lead to t

165 A general model indicates a marrow cell that can continual

166 A quantitative and general model is derived for the interaction potential o

167 The general model is described and illustrated by examining

168 A general model is developed to characterize the effect of

169 On the basis of these results, a general model is proposed for the interfacial binding of

170 A general model is proposed whereby up to 10 levels of sig

171 This general model is tested in a matching task in which rewa

172 The general model is, typically, analytically intractable, b

173 Our general model may also be applicable to other small neur

174 r the tether material after crossover, and a general modeling method for tether pulling experiments.

175 results with computational simulations using general model networks and anatomical brain networks, as

176 We introduce and analyze a general model of a population evolving over a network of

177 We present a general model of actin filament deformation and fragment

178 Here, we develop a general model of admixture that mechanistically accounts

179 etailed quantitative agreement with a recent general model of allosteric cooperativity that exhibits

180 on of the mature T-cell compartment and as a general model of binary lineage decisions, the underlyin

181 I then develop a very general model of cancer progression, which I use to expl

182 These results support a general model of chaperone-mediated protein quality cont

183 reserve therefore provides an empirical yet general model of cognitive aging and development.

184 A general model of coronary vascular development should no

185 Our results suggest a general model of cortical function, whereby horizontal c

186 The general model of covalently attaching a small protein as

187 Animal models have implicated a general model of crystal-induced inflammation involving

188 : a commonly used predator-prey model, and a general model of cyclic trophic interactions.

189 These results suggest a general model of DMPK regulation with two main regulator

190 In this paper we present a general model of drug release from a drug delivery devic

191 Here we derive a general model of ecosystem respiration based on the kine

192 However, we propose a general model of endemic stability that is applicable to

193 orage, and use these patterns to formulate a general model of energy allocation between growth, lipid

194 hese patterns we propose DEBlipid, a simple, general model of energy allocation that is closely relat

195 We use the framework of a general model of fractal-like distribution networks toge

196 t about by "globalization," application of a general model of freedom based on ecological-economic fa

197 -specificity of HpTx2 and point the way to a general model of gating modifier toxin interaction with

198 propose hierarchical Gaussian processes as a general model of gene expression time-series, with appli

199 While a general model of H2 activation has been proposed for [Fe

200 These results suggest a general model of how MADS-box proteins recognize and bin

201 These findings suggest a general model of how pH-dependent proteinaceous inhibito

202 Our observations lead to a general model of how substrates, such as ethanol, can re

203 rial dysfunction and cardiomyopathy and as a general model of inducible, reversible cardiomyopathy.

204 In this review, we discuss a general model of integration of environmental cues by Tr

205 eoretical analysis of a previously-developed general model of inter-trial error correction is used to

206 ap sizes and shapes in the ectoderm, using a general model of interstitial gap mechanics.

207 We use our quantitative results to propose a general model of long-range electrostatic screening in i

208 rovide experimental evidence to support this general model of memristive electrical switching in oxid

209 We find that a general model of morphological selectivity has a low pro

210 A general model of neural development is derived to fit 18

211 we extend this framework by linking it to a general model of parasite accumulation.

212 Here, we use a general model of periodic patterning to show that differ

213 these findings support the conclusion that a general model of permeability will require consideration

214 to colocalize in RPE, CE, and MDCK cells, a general model of polarized epithelia.

215 also point to a new, biologically important general model of precise and selective interaction betwe

216 These results indicate that a general model of protein evolution will emerge as more f

217 can be fabricated on silicon, and suggest a general model of quantum-state fabrication using other c

218 In this study, a general model of recombination in circular molecules is

219 Here we develop a general model of recurrent selective sweeps in a coalesc

220 nder anoxic conditions and also serving as a general model of saturated pyrimidine residues.

221 The general model of selective sweeps we describe goes some

222 To provide the experimental basis for a general model of short-term plasticity, we studied three

223 Here, we study a general model of spatially embedded networks with depend

224 Here, we introduce a general model of spurious association in structured popu

225 We describe here a general model of structural variation that encompasses b

226 I construct a general model of the interactive feedbacks of host prefe

227 We describe here a general model of the kinetic mechanism of protein foldin

228 learned joint torque responses rather than a general model of the object interface forces.

229 Replication concepts are defined and a general model of the steps in DNA replication is present

230 onstraints based on the previously developed general model of the transmembrane alpha-bundle for rhod

231 These observations also led to a general model of the unfolding transition state structur

232 A general model of this process, the territorial-expansion

233 The main conclusion of the study is that a general model of vasomotion that predicts experimental d

234 We develop a general model of word formation and demonstrate the conn

235 The results lead us to propose a general model of Zn2+ inhibition of GABAA receptors in w

236 ton acceptor or the tyrosine, in accord with general models of amino acid radicals.

237 Over 25 years of study have produced two general models of apoA-I structure in discoidal HDL comp

238 We have developed general models of capsid assembly that describe the proc

239 perates in time will be necessary to develop general models of cognition.

240 This functional similarity has led to general models of elongation applicable to both eukaryot

241 iminish and it became incorporated into more general models of higher dysfunction.

242 ntemporary research reflects several themes: General models of job performance are being developed, t

243 spectrum in a finite population for several general models of multiallelic selection.

244 s age, many studies have claimed support for general models of range evolution in which the area occu

245 In general, modeling oil-recovery is a challenging problem

246 General models on the evolution of policing have focused

247 The general model organism database (GMOD) tool kit has prod

248 models of hourly PNC was limited, but that a general model performed acceptably in multiple areas whe

249 ng approaches, we are able to perform a more general model prediction that takes into account the sus

250 The general model presented advances previous treatments, an

251 We end by considering a general model proposing that adult neurogenesis is not a

252 We demonstrate that our general model provides a host of specific insights, incl

253 Our findings provide an initial general model relating small molecule binding and sequen

254 We build an analytical and general model resulting from simplifications assuming sm

255 cts and tests whether the predictions of the general models still hold.

256 l correlation, provided as good a fit as the general model, suggesting that environmental and/or poly

257 This general model suggests that the roles of nicotinic and m

258 , we analyze the analytical predictions of a general model suitable for describing the spatial biodiv

259 ctal and rodent retinocollicular systems are general model systems used to examine developmental proc

260 However, a general model that accounts for the formation and evolut

261 putational work is remarkable and provides a general model that can be used for studying the interact

262 erized as part of an instantiation of a more general model that describes the interaction between und

263 functional theory calculations, we suggest a general model that enables prediction of the feasibility

264 onent analysis can be utilized to estimate a general model that includes the well-known Pritchard-Ste

265 We propose a general model that incorporates both such extreme hypoth

266 ing force in gradient dynamics, we develop a general model that is capable of capturing both subtle a

267 ard, as a possible explanation, a simple and general model that relates these data to the steric hind

268 inding regions in the parameter space of the general model that results in a quasispecies only compos

269 Finally, we develop a general model that shows how these effects can be captur

270 We then developed a general model that shows these individual fitness reduct

271 s an alternative, this study proposes a more general model that uses detailed organism and tissue com

272 different environments - we achieved a more general model that well-predicted leaf age across forest

273 Two general models that are consistent with the biochemical

274 rate our knowledge, it is necessary to build general models that begin with an input image and predic

275 ween theory and data, we study a simple, but general, model that explicitly focuses on the dynamics o

276 In general, models that allow chimps to have a larger per-r

277 ecent studies question whether the classical general model (the Jeffress model) applies across specie

278 Under the conditions of this general model, the maximum expected correlation between

279 This approach results in a simple and general model to account for product accumulation in int

280 We have recently proposed a general model to account for these atypicalities in Baye

281 divergence, containing the foundations for a general model to anticipate and predict within-target-fa

282 We develop a general model to describe both loss of immunity in the a

283 Here, we present a general model to show that this type of interaction can

284 We apply this general model to study assembly of FtsZ protein, a basic

285 We attempt to test three possible general models to account for this behavior: 1) The Q(o)

286 ition of distinct island geodynamics permits general models to be developed and modified to account f

287 Thus, the general model unifies the four major models of reproduct

288 with alpha-quaternary centers, have led to a general model useful for the prediction of product selec

289 A general model was applied to discriminate high-quality n

290 A general model was developed to assist in the rational de

291 This general model was tested within a phylogenetically infor

292 Using a general model we predict the qualitative and quantitativ

293 Here we examine a general model where population growth can be induced or

294 ion of the transition density function for a general model where the effective population size, selec

295 ubiquitous in nature, our results support a general model whereby antagonistic interactions and natu

296 Our findings support a general model whereby DNA ligand binding with VirD4 and

297 This approach forms the basis for our general model, which predicts sites on drugs that are su

298 in two ways-by considering (analytically) a general model with a minimal number of assumptions and,

299 that was a thousand-fold larger than a more general model within which the first model was fully nes

300 less than or equal to the probability of the general model within which the special case is nested.