ライフサイエンスコーパス: general transcription factor

1 pends upon promoter recognition by the SNAPC general transcription factor.

2 nal transduction pathway, and by Mediator, a general transcription factor.

3 loenzyme-associated regulatory protein and a general transcription factor.

4 etailed biochemical characterization of this general transcription factor.

5 IC), which consists of RNA polymerase II and general transcription factors.

6 lamina formation and nuclear import of other general transcription factors.

7 ed in DNA binding and interaction with other general transcription factors.

8 s recruited to promoters by interaction with general transcription factors.

9 roughout the genome, a hallmark attribute of general transcription factors.

10 ransactivators, coactivators, mediators, and general transcription factors.

11 evels of RNA polymerase II and corresponding general transcription factors.

12 tion, the latter occurring in the absence of general transcription factors.

13 order of magnitude as RNA polymerase II and general transcription factors.

14 ript and/or the template, independent of the general transcription factors.

15 transcriptional repression are controlled by general transcription factors.

16 ses pointed to acylglycerol kinase (AGK) and general transcription factor 2-I (GTF2I) as positional a

17 ophobe: amylases 1A, 1B, and 1C; oncocytoma: general transcription factors 2H2, 2B, 2C, and 2D).

18 General transcription factor 3 (GTF3) binds specifically

19 A hallmark of general transcription factor 3 (GTF3) is the presence of

20 ast one-hybrid screen, we isolated cDNAs for general transcription factor 3 (GTF3)/muscle TFII-I repe

21 irectly with the glucocorticoid receptor and general transcription factors, acting as a coactivator.

22 Polycomb anchoring to DNA, and implicate the general transcription factor ADF1 as a novel PRE compone

23 Thus, RapA acts as a general transcription factor and an integral component o

24 The discovery of germ cell-specific general transcription factor and coactivator variants ha

25 ivation domain is responsible for recruiting general transcription factors and coactivators to IE pro

26 ructural motifs, one of which interacts with general transcription factors and coactivators, and the

27 ate function of this network also depends on general transcription factors and cofactors that are ubi

28 For the former effects, AADs bind general transcription factors and larger coactivator com

29 ng the association of promoter DNA only with general transcription factors and not with the polymeras

30 We also found that subsets of general transcription factors and Pol II can form stable

31 (Pol II) is a complex process that requires general transcription factors and Pol II to assemble on

32 subunits and provides the binding sites for general transcription factors and Pol II.

33 wing stages: assembly of the polymerase with general transcription factors and promoter DNA in a 'clo

34 hanism through which Tax communicates to the general transcription factors and RNA polymerase II has

35 e-4 trimethylation and in the recruitment of general transcription factors and RNA polymerase II in t

36 ther Tax could function directly through the general transcription factors and RNA polymerase II or i

37 The head and middle modules interact with general transcription factors and RNA polymerase II, whe

38 on assays reconstituted with highly purified general transcription factors and RNAPII.

39 nzyme, and is in a position to interact with general transcription factors and the Mediator of transc

40 patocellular (HepG2) carcinoma extracts, the general transcription factors and transactivators presen

41 activation domain of VP16 can associate with general transcription factors and with chromatin-modifyi

42 ons reconstituted with highly purified yeast general transcription factors and, importantly, that the

43 at c-Myc binds to TFIIIB, a pol III-specific general transcription factor, and directly activates pol

44 re used to probe the presence of activators, general transcription factors, and chromatin-modifying c

45 DNA-binding proteins, chromatin regulators, general transcription factors, and elongation factors.

46 s indicates that histone acetyltransferases, general transcription factors, and Mediator subunits are

47 is of an 8 nt RNA, occurs independent of the general transcription factors, and requires under-windin

48 o reconstituted system including pol II, the general transcription factors, and TFIIS.

49 e-step model in which nucleosome remodelers, general transcription factors, and the transcriptional e

50 initiation competent form of RNA pol II and general transcription factors appeared in the daughter n

51 Why certain point mutations in a general transcription factor are associated with specifi

52 reactions reconstituted from highly purified general transcription factors are CTD-independent.

53 Although it is established that some general transcription factors are inactivated at mitosis

54 General transcription factors are required for productiv

55 RNA polymerases (or associated general transcription factors) are hypothesized to reach

56 ires that RNA polymerase II (Pol II) and the general transcription factors assemble on promoter DNA t

57 ional activators and repressors compete with general transcription factors at each step to influence

58 or the proper assembly and activation of the general transcription factors at promoters.

59 ylation of histone H3 and recruitment of the general transcription factors at the HepG2 SNAT2 promote

60 nucleosomes are relocated to allow sites of general transcription factor binding and transcription i

61 This stimulation of mediator, Pol II, and general transcription factor binding to promoter DNA cor

62 inhibitor of Vpr, possibly by retaining its general transcription factor-binding activities.

63 t bind to AR1 in gel shift experiments, this general transcription factor binds to AR1 in the presenc

64 We propose that TFE and the bacterial general transcription factor CarD, although structurally

65 cription systems reconstituted with purified general transcription factors, cofactor, RNA polymerase

66 On this basis, Mediator is identified as a general transcription factor, comparable in importance t

67 site at GAL10 by Reb1p activator as well as general transcription factors (e.g., TFIID, TFIIB, and M

68 pended on cross-linking, including Mediator, general transcription factors, elongation factors, ribon

69 eral transcription factor TFIID, is the only general transcription factor encoded by an intronless ge

70 ndicate that a combinatorial regulation of a general transcription factor-encoding gene can be confer

71 hows a FRAP that is 100-fold slower than the general transcription factor GFP-TFIIB.

72 We show that GENERAL TRANSCRIPTION FACTOR GROUP E6 (GTE6) regulates d

73 NRC-1, we discoverd subtle differences in a general transcription factor (GTF) binding site motif ac

74 hereas individual RNA polymerase II (pol II)-general transcription factor (GTF) complexes are unstabl

75 TFIIB is an RNA polymerase II general transcription factor (GTF) that has also been im

76 requires the coordinated action of multiple general transcription factors (GTFs) and RNA polymerase

77 ivision in two parts, one containing all the general transcription factors (GTFs) and the other pol I

78 ment of histone modification enzymes and the general transcription factors (GTFs) by activators.

79 /EBP activators, polymerase II (Pol II), and general transcription factors (GTFs) initially occurred

80 tment of chromatin remodeling activities and general transcription factors (GTFs) to promoters.

81 involves the ordered assembly of a number of general transcription factors (GTFs), all of which have

82 ion occurs through interactions of HSFs with general transcription factors (GTFs), as has been descri

83 ein assemblies in the nucleus, including the General Transcription Factors (GTFs), RNA polymerase II

84 itiation complexes (PICs), which contain the general transcription factors (GTFs), RNA polymerase II

85 The evolution of tissue-specific general transcription factors (GTFs), such as testis-spe

86 x, which comprises RNA polymerase II and its general transcription factors (GTFs).

87 While general transcription factors have been extensively stud

88 a heteroduplex DNA template do not depend on general transcription factors; however, transcriptional

89 pen reading frame and is the only intronless general transcription factor identified so far.

90 The general transcription factor II B (TFIIB) plays a centra

91 The general transcription factor II H (TFIIH) is a major act

92 ed association with the transcription factor general transcription factor II-I (TFII-I).

93 ion factors that regulate Mkx In particular, general transcription factor II-I repeat domain-containi

94 Here we report the importance of general transcription factor II-I repeat domain-containi

95 The general transcription factor IIA (TFIIA) stimulates RNA

96 bunit (Toa1p and Toa2p, respectively) of the general transcription factor IIA (TFIIA).

97 In this study, we identified general transcription factor IIA gamma (TFIIA gamma) as

98 We describe a unigenic evolution analysis of general transcription factor IIB (TFIIB) - a protein tha

99 Here, we show that general transcription factor IIB (TFIIB) and cyclin-depe

100 The structure of the general transcription factor IIB (TFIIB) in a complex wi

101 The general transcription factor IIB (TFIIB) is required for

102 The general transcription factor IIB (TFIIB) plays an essent

103 but enhanced the interaction of TBP with the general transcription factor IIB (TFIIB).

104 t interaction of the non-coding RNA with the general transcription factor IIB and dissociation of the

105 e cargoes include another PIC component, the general transcription factor IIB or Sua7p, which interac

106 General transcription factor IID (TFIID) is a multisubun

107 The general transcription factor IID (TFIID) plays a central

108 or 1 (TAF1) is an essential component of the general transcription factor IID (TFIID), which nucleate

109 The general transcription factor IIE (TFIIE) is essential fo

110 SNEV, and RAP74 (the largest subunit of the general transcription factor IIF).

111 the core complex of yeast RNA polymerase II general transcription factor IIH (TFIIH) by affinity pur

112 General transcription factor IIH (TFIIH) consists of nin

113 The general transcription factor IIH (TFIIH) is held at prom

114 e nucleotide polymorphism variant within the general transcription factor IIH, polypeptide 4 gene, GT

115 Although associated general transcription factors impart promoter specificit

116 P-dependent chromatin-remodeling factor by a general transcription factor in vivo.

117 re consistent with Mediator functioning as a general transcription factor in yeast.

118 ed only in specific cell types interact with general transcription factors in a combinatorial manner

119 ing to define positions of RNAP subunits and general transcription factors in an archaeal initiation

120 sed to define positions of RNAP subunits and general transcription factors in bacterial and eukaryal

121 ween E2F binding sites and binding sites for general transcription factors in both normal and tumor c

122 tional diversity of the regulon of the other general transcription factors in E. coli, the functions

123 e mechanism of transcription and the role of general transcription factors in the initiation of the p

124 specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanoso

125 By varying the concentrations of general transcription factors in the reaction mixtures,

126 cal and genetic system to study the roles of general transcription factors in transcription initiatio

127 s known about the dynamic behavior of Pol II general transcription factors in vivo.

128 However, several other general transcription factors, in particular the mediato

129 e suggests that significant changes in these general transcription factors including TFIID, BAF, and

130 pond to the binding sites of Pol II-specific general transcription factors including TFIIF, TFIIH and

131 After inactivation of several general transcription factors, including TBP, TAFs are s

132 One subset of these proteins (general transcription factors) interacts with the TBP.TA

133 cription initiation requires the assembly of general transcription factors into a pre-initiation comp

134 major reservoir of activity where P-TEFb, a general transcription factor key for RNA polymerase II e

135 A elements and directs the assembly of other general transcription factors, leading to binding of RNA

136 tion as to the structure and function of the general transcription factors, little is known about the

137 an example of how regulated activity of the general transcription factors may contribute to inducibl

138 d complexes, including chromatin remodeling, general transcription factor, mediator, and polymerase c

139 anscription requires the late recruitment of general transcription factors, mediator and Pol II not o

140 constituted from homogeneous preparations of general transcription factors, Mediator-associated Pol I

141 RfaH, a paralog of the general transcription factor NusG, is recruited to elong

142 cle-dependent kinases (CDKs) associated with general transcription factors of the promoter complex, s

143 nal directionality and selective assembly of general transcription factors on the core sense promoter

144 cked by pre-assembling activator and certain general transcription factors on the promoter and then a

145 Families whose members comprise general transcription factor or RNA polymerase subunits

146 yeast TATA-less genes and suggest that other general transcription factors or coactivator subunits ar

147 ducer of cell differentiation, targeting the general transcription factor P-TEFb by HEXIM1/7SK may co

148 The general transcription factor P-TEFb stimulates RNA polym

149 may result from their dynamic control of the general transcription factor P-TEFb.

150 Thus, in an in vitro assay with general transcription factors, Pol II lacking Gdown1 dis

151 ings support a model in which Pol II and the general transcription factors rapidly bind promoter-boun

152 titutively occupied by RNA polymerase II and general transcription factors regardless of p53 activity

153 TBP) and TBP-associated factors (TAFs), is a general transcription factor required for RNA polymerase

154 TFIID is a general transcription factor required for the assembly o

155 t whole-cell extract with TFIIH, the largest general transcription factor required for transcription

156 TFIID is a general transcription factor required for transcription

157 TATA-binding protein (TBP) is a key general transcription factor required for transcription

158 lymerase III-transcribed genes have distinct general transcription factor requirements for repression

159 mation, whereas efficient recruitment of the general transcription factors requires the TATA box.

160 h TFIIH for efficient communication with the general transcription factors/RNA polymerase II on the c

161 tivates EHV-1 promoters by interactions with general transcription factor(s).

162 CK2 phosphorylates the general transcription factor small nuclear RNA-activatin

163 scription by RNA polymerase III requires the general transcription factor SNAP(C), which binds to hum

164 Here we demonstrate that the general transcription factors snRNA-activating protein c

165 enes regulated by Abf1p and those by several general transcription factors such as Mot1p and TAFs (TA

166 For instance, plant general transcription factors such as TFIIB have expande

167 ing fission yeast to study the properties of general transcription factors such as TFIIB in choosing

168 ications associated with the assembly of the general transcription factors, such as histone H3 lysine

169 Typical general transcription factors, such as TATA binding prot

170 s are believed to work in part by recruiting general transcription factors, such as TATA-binding prot

171 sis is mediated through sequestration of the general transcription factor TAF-4 and is regulated by m

172 region and is completely dependent upon the general transcription factor TAF1 (TAF(II)250).

173 s regulate each other indirectly through the general transcription factor TAF7.

174 essing HRAS(V12), elevated expression of the general transcription factor TATA-box binding protein (T

175 The archaeal general transcription factors TATA-element-binding prote

176 how that CtIP and CtBP can interact with the general transcription factors, TATA binding protein and

177 ssess two TATA-binding protein homologs, the general transcription factor TBP and a related factor ca

178 ement in cells but also the occupancy of the general transcription factors TBP and TFIIB at the repor

179 The in vitro binding with general transcription factors TBP and TFIIB together wit

180 ng the flanking blocks influenced binding by general transcription factors TBP and TFIIB.

181 DNA specificities and affinities for the general transcription factors TBP, TFIIA and IIB determi

182 rbors extremely divergent orthologues of the general transcription factors TBP, TFIIA, TFIIB and TFII

183 revisiae RNA polymerase II (RNAP II) and the general transcription factors TBP, TFIIB, and TFIIF on p

184 Our results suggest that CTCF, RAD21, a general transcription factor (TBP) and activating chroma

185 but require the support of only two archaeal general transcription factors, TBP (TATA-box binding pro

186 reventing archaeal TATA-box binding protein, general transcription factor TFB, and RNAP access and th

187 I-like enzyme, and its interactions with the general transcription factor TFE, as well as with the tr

188 Gtf2ird1 encodes a polypeptide related to general transcription factor TFII-I, and it is the mouse

189 uman TATA-element binding protein (TBP) with general transcription factor TFIIA and transcriptional r

190 e1-mediated (TASP1-mediated) cleavage of the general transcription factor TFIIA ensures proper coordi

191 ICP4 has a differential requirement for the general transcription factor TFIIA in vitro.

192 he N-terminal domain (NTD) of the RNA Pol II general transcription factor TFIIA.

193 terpart of the large (alpha/beta) subunit of general transcription factor TFIIA.

194 h the transcriptional regulator Mot1 and the general transcription factor TFIIA.

195 criptional coregulator subunits and with the general transcription factor TFIIA.

196 General transcription factors TFIIA and TFIIB bound glut

197 General transcription factors TFIIA, -B, -D, -E, -F, -H

198 This study shows that a general transcription factor, TFIIA gamma, facilitates o

199 x and is in competition with binding another general transcription factor, TFIIA.

200 6Me3), as well as reduced recruitment of the general transcription factor TFIIB and increased overall

201 causes abnormal interaction of TBP with the general transcription factor TFIIB and induces neurodege

202 ptional activation domain interacts with the general transcription factor TFIIB and that this interac

203 A structure of an RNA polymerase II-general transcription factor TFIIB complex at 4.5 angstr

204 The general transcription factor TFIIB is a highly conserved

205 The general transcription factor TFIIB is a key component in

206 However, the general transcription factor TFIIB is presumed to be uni

207 The general transcription factor TFIIB is required for accur

208 The general transcription factor TFIIB plays a central role

209 The general transcription factor TFIIB plays a crucial role

210 ical probes positioned on the surface of the general transcription factor TFIIB were used to probe th

211 d, activators physically interacted with the general transcription factor TFIIB when the genes were a

212 nd TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal tr

213 f sequence similarity with the polymerase II general transcription factor TFIIB, but it is the carbox

214 occur in the presence of an antibody to the general transcription factor TFIIB, indicating the trans

215 Here we show that the general transcription factor TFIIB, which is required fo

216 the IE protein physically interacts with the general transcription factor TFIIB.

217 of unknown function that interacts with the general transcription factor TFIIB.

218 affinity RNA aptamers that bind to the yeast general transcription factor TFIIB.

219 Moreover, looping is dependent upon the general transcription factor TFIIB: the E62K (glutamic a

220 er-order complexes containing the additional general transcription factors TFIIB and TFIIA.

221 d archaeal Pol requires structurally related general transcription factors TFIIB, Brf1, and TFB, resp

222 iption system reconstituted with recombinant general transcription factors (TFIIB, TBP, TFIIE, TFIIF)

223 n)-associated factors that are components of general transcription factor TFIID (dTAFIIs).

224 AF(II)55) is a component of the multisubunit general transcription factor TFIID and has been shown to

225 The general transcription factor TFIID and its individual su

226 s an integral subunit of both the 15-subunit general transcription factor TFIID and the multisubunit,

227 two transcription regulatory complexes, the general transcription factor TFIID and the Spt-Ada-Gcn5

228 The general transcription factor TFIID comprises the TATA-bo

229 many chromatin remodeling complexes and the general transcription factor TFIID contain bromodomains,

230 The general transcription factor TFIID facilitates recruitme

231 hat acetyl-CoA increased the affinity of the general transcription factor TFIID for promoter DNA in a

232 a concise molecular characterization of the general transcription factor TFIID from S. cerevisiae.

233 The RNA polymerase II general transcription factor TFIID is a complex containi

234 General transcription factor TFIID is a cornerstone of R

235 General transcription factor TFIID is a key component of

236 The general transcription factor TFIID is a multiprotein com

237 The general transcription factor TFIID is a multisubunit com

238 The general transcription factor TFIID is composed of the TA

239 The general transcription factor TFIID is composed of the TA

240 The general transcription factor TFIID recognizes specifical

241 The general transcription factor TFIID sets the mRNA start s

242 The CREB CAD interacts with the general transcription factor TFIID through one or more o

243 Human TAF5, a 100-kDa subunit of general transcription factor TFIID, is an essential gene

244 TAF(II)250, the largest subunit of the general transcription factor TFIID, is expressed from th

245 n TAF(II)55 (hTAF(II)55), a component of the general transcription factor TFIID, is the only general

246 Bdf1 interacts with the general transcription factor TFIID, which might promote

247 he recruitment of the SWI/SNF complex by the general transcription factor TFIID.

248 associates with TAFII250, a component of the general transcription factor TFIID.

249 more ubiquitously expressed component of the general transcription factor TFIID.

250 14 TBP-associated factors (TAFs) to form the general transcription factor TFIID.

251 BP-associated factors (TAF(II)s) compose the general transcription factor TFIID.

252 includes RNA polymerase II (Pol II) and the general transcription factors TFIID, TFIIA, TFIIB, TFIIF

253 The general transcription factor, TFIID, consists of the TAT

254 TAF(II)250, a component of the general transcription factor, TFIID, is required for the

255 Human general transcription factor TFIIE consists of two subun

256 sequences of the alpha-subunits of eucaryal general transcription factor TFIIE.

257 t 50% of Pol II is found associated with the general transcription factor TFIIF (Pol II-TFIIF), and a

258 The structure of an RNA polymerase II/general transcription factor TFIIF complex was determine

259 eveal how the Gdown1 protein antagonizes the general transcription factor TFIIF during RNAPII initiat

260 The RNA polymerase (pol) II general transcription factor TFIIF functions at several

261 ivation domain (amino acids 142-485) and the general transcription factor TFIIF.

262 tivity has been shown to be regulated by the general transcription factors TFIIF (RAP74) and TFIIB, p

263 ch constitute the TFIIK kinase subcomplex of general transcription factor TFIIH and to mutations in C

264 ody indicates that the AR interacts with the general transcription factor TFIIH in a physiological co

265 of the large subunit of RNA polymerase II by general transcription factor TFIIH is believed to be an

266 CDK7 is the kinase subunit of the general transcription factor TFIIH that phosphorylates t

267 reatly stimulates the CTD kinase activity of general transcription factor TFIIH, and subsequent CTD p

268 orted to bind to XPB, the largest subunit of general transcription factor TFIIH, and to cause degrada

269 alized with transcription sites and with the general transcription factor TFIIH, but not with the spl

270 General transcription factor TFIIH, previously described

271 valent modification of XPB, a subunit of the general transcription factor TFIIH.

272 viral nonstructural protein NSs and the host general transcription factor TFIIH.

273 O15/Cdk7, also functions as a subunit of the general transcription factor TFIIH.

274 al levels of recruitment and activity of the general transcription factor TFIIH.

275 se, and in transcription, as a module of the general transcription factor TFIIH.

276 a subunit of the RNA polymerase III-specific general transcription factor TFIIIC, comprises an N-term

277 ns (80 polypeptides): RNA polymerase II, six general transcription factors, TFIIS, the Pho4 gene acti

278 from different biological subsystems such as general transcription factors (TFs), cellular growth fac

279 The TATA-binding protein (TBP) is a critical general transcription factor that associates with the co

280 TBP) is a highly conserved RNA polymerase II general transcription factor that binds to the core prom

281 l Mfd ATPase is increasingly recognized as a general transcription factor that participates in the re

282 tivities of these promoters are dependent on general transcription factors that inhibit Pol II elonga

283 increased SNAT2 promoter association of the general transcription factors that make up the preinitia

284 prising an RNAPII-like enzyme as well as two general transcription factors, the TATA-binding protein

285 One of the general transcription factors, then, may be subject to r

286 s for the production of an active TFIIA-like general transcription factor throughout oogenesis.

287 not only with transcriptional activators and general transcription factors to enhance activated trans

288 It functions along with the cellular general transcription factors to increase the transcript

289 at integrates regulatory inputs and recruits general transcription factors to initiate transcription.

290 h stimulate binding of mediator, Pol II, and general transcription factors to promoter DNA in extract

291 S(V12) promote proliferation by upregulating general transcription factors to stimulate RNA synthesis

292 Mediator is required for recruitment of the general transcription factors to the core promoter.

293 dered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter.

294 at the enhancers but also the recruitment of general transcription factors to the promoter.

295 rogram of chromatin modifiers/remodelers and general transcription factors to the promoter.

296 atin modifiers/remodelers, coactivators, and general transcription factors to the promoters of target

297 nitiation complex by binding not only to the general transcription factors together with RNA polymera

298 Relative binding affinity for general transcription factors was measured for 12 of the

299 In contrast, Mediator and the general transcription factors were blocked during assemb

300 The c-Myc oncoprotein is a general transcription factor whose target genes dictate