ライフサイエンスコーパス: generation

1 amete genomes that are passed on to the next generation.

2 as indicated by random segregation in the T2 generation.

3 tudy that compares their usefulness to model generation.

4 such a workflow is detrimental to hypothesis generation.

5 O); and (3) N2O conversion to N2 with energy generation.

6 ic acid on alternative pathways for ceramide generation.

7 through PKA activation and subsequent cADPR generation.

8 f a spin chain and maximise the entanglement generation.

9 nd neurotransmitter receptor-stimulated cAMP generation.

10 ting thrombopoiesis, the process of platelet generation.

11 olysis and uncoupling biosynthesis from NADH generation.

12 fitness of F1 hybrids and recovery in the F2 generation.

13 Quin/Fe(II) and low pH enhance the OH generation.

14 dently sustain appreciable long-lived charge generation.

15 ations from bioelectronics to energy storage/generation.

16 lved excessive reactive oxygen species (ROS) generation.

17 o the mantle and past the zones of arc magma generation.

18 t-matter interaction, especially in harmonic generations.

19 hylation returns to a normal level over four generations.

20 overned by the flow of capital to subsequent generations.

21 adapting to growth in galactose for up to 8 generations.

22 -generation intervals through sixty thousand generations.

23 es (2-32), and tracked populations for seven generations.

24 resistance had spread to high levels by 500 generations, 56% favoured sequential use and 44% favoure

25 gy costs, highlights their potential as next-generation adsorbents for a wide array of CO2 separation

26 ion (ie, earlier disease onset in successive generations), although the differences in age at onset a

27 erial community structure determined by next-generation amplicon sequencing.

28 ion, functional studies reveal reduced force generation and a dilated cardiomyopathy (DCM) phenotype.

29 beta7(high) subsets enhanced Th1/Th17 T cell generation and accumulation in the intestine, and the di

30 mportance of factors that contribute to heat generation and accumulation.

31 ration capacity that relied on the enzymatic generation and active provision of a procoagulant phosph

32 arkably suppressed palmitic acid-induced ROS generation and apoptosis.

33 Here the authors demonstrate efficient generation and characterization of 53 as pulses with pho

34 he available experimental techniques for the generation and characterization of electron bunches with

35 able detailed, mechanistic dissection of MCC generation and checkpoint silencing.

36 ne provides a novel technique for hypothesis generation and complements classic GWAS interpretation.

37 that included neutrophil extracellular trap generation and elevated surface expression of toll-like

38 des caused by uncontrolled plasma kallikrein generation and excessive bradykinin release resulting fr

39 5 expression improves the efficiency of iPSC generation and impedes processing of miR-125b, leading t

40 r in trials with inadequate/unknown sequence generation and inadequate/unknown allocation concealment

41 4-MD2 complex that triggers endocytosis, ROS generation and increases pro-interleukin-1beta expressio

42 checkpoint, triggered by appressorium turgor generation and melanization.

43 ished to elucidate the mechanisms of radical generation and mineral surface complexation.

44 gether, our study shows PKC/NOX-mediated ROS generation and PARP-1 activation as an important mechani

45 d IL-1beta did not vitally contribute to the generation and plasticity of Th17 cells, but rather prom

46 e matter tracts known to be important in the generation and propagation of temporal lobe seizures in

47 ODG is a user-friendly database generation and query tool that adapts to the supplied da

48 e effects of molecular orientation on charge generation and recombination.

49 is, enhanced proteolysis, inefficient energy generation and reduced cell growth.

50 enetic diversity is maintained by continuing generation and removal of variants.

51 ro and in vivo through tumor-specific (1) O2 generation and subsequent ROS mediated mechanism.

52 myosin's ATPase cycle associated with force generation and the conversion of chemical energy into me

53 ncover quintessential architectures of chaos generation and the underlying physics.

54 must activate aerobic glycolysis for energy generation and uncouple NADH generation from biosynthesi

55 of the human myocardium requires the proper generation and utilization of energy and relies on a ser

56 role in respiration, reactive oxygen species generation, and energy production.

57 The former are required for the current generation, and the latter create offspring.

58 duced apoptosis accompanied by increased ROS generation, and the stimulation of autophagy by rapamyci

59 ound to induce cell death independent of ROS generation, and unlike many natural product based HDAC i

60 ced NOX4 expression, reactive oxygen species generation, and, matrix laminin expression.

61 y of idelalisib in combination with a second-generation anti-CD20 antibody, ofatumumab, in a similar

62 ificant difference in the efficacy of second-generation antidepressants (SGAs) versus most other trea

63 as PD-1 blocking antibodies, offering a next-generation approach in the design of immunotherapeutic a

64 The next-generation AR antagonist, enzalutamide, prolongs surviva

65 transfer (ET) rate constants driving the VOC generation are shown to vary with the chirality-associat

66 harmacological interference with IgA(+) cell generation attenuates liver carcinogenesis and induces c

67 study, we report the development of a second-generation BET protein degrader, BETd-246, which exhibit

68 ith dynein and is required for pulling force generation, but the dynamics of this process remain uncl

69 We describe here how rates of ATP generation by each pathway can be calculated from simult

70 emoval coupled to N2O generation in a second generation CANDO process, CANDO+P.

71 s by exhibiting a strong endogenous thrombin-generation capacity that relied on the enzymatic generat

72 ates that the selection pressures of a 3(rd) generation cephalosporin and chlortetracycline during th

73 However, some later-generation cephalosporins, including cefepime, are poorl

74 nt energy storage is in high demand for next-generation clean energy applications.

75 ants from the Framingham Offspring and Third Generation Cohorts (n=3318; aged 48.9+/-10.3 years), who

76 tudy were to develop a model to describe the generation, consumption and release of heat from landfil

77 Computer-based randomisation with sequence generation defined by permuted block randomisation (bloc

78 These results have implications for the next-generation design of receptors used in adoptive T cell t

79 Two "first-generation," directly radiolabeled anti-CD20 antibodies,

80 We demonstrate that targeted next-generation DNA sequencing reactions and in situ point mu

81 a paucity of contemporary data on the second-generation drug-eluting stent use within SVG, and the re

82 dels to assess the association between later-generation fluoroquinolone (moxifloxacin or levofloxacin

83 bles tumor-specific singlet oxygen ((1) O2 ) generation for cancer therapy, based on a Fenton-like re

84 nd catalyses C-H hydride abstraction plus H2 generation from a model substrate.

85 ysis for energy generation and uncouple NADH generation from biosynthesis.

86 By applying next-generation functional testing of primary patient-derived

87 We screened 36,530 third-generation germline mutant mice derived from N-ethyl-N-n

88 and nondispatchable nature of wind and solar generation has been driving interest in energy storage a

89 and then transferred to elevated CO2 for 20 generations (HC).

90 litates the accumulation of knowledge across generations, helping people and artificial intelligences

91 In this study, we employed the next generation high-throughput deep sequencing technology to

92 "Next-generation" implantable hemodynamic monitors are in deve

93 us biological N and P removal coupled to N2O generation in a second generation CANDO process, CANDO+P

94 Palmitate-induced ROS generation in human CD68(low)CD14(high) macrophages is s

95 plifier and its application to high-harmonic generation in solids.

96 increasing the hematocrit increased thrombin generation in the absence of platelets; however, this ef

97 We mechanistically studied tTreg cell generation in the atrophied thymus by utilizing both pos

98 on would allow phase-matched dispersive wave generation in the mid-infrared-something that is forbidd

99 almost 9000 mutations accumulated over five generations in eight MMR-deficient mutation accumulation

100 e GC and Tfh-cell processes involved in bnAb generation, including the difficulty of quantifying anti

101 trol, autonomous structures, motion and work generation, information processing) rather than on speci

102 enome metagenomic sequencing at five hundred-generation intervals through sixty thousand generations.

103 Over six generations, invasions with any amount of genetic mixtur

104 The cell-based H2O2 generation is affected by the medium volume, the cell co

105 Solar photovoltaic (PV) electricity generation is expanding rapidly in China, with total cap

106 henotypic plasticity, both within and across generations, is an important mechanism that organisms us

107 such as synthesis of DNA and RNA and energy generation, it may represent a potential target for deve

108 The development of first-generation land surface models as a unifying framework f

109 ic signal enhancement with a specific signal generation, leading to an enhanced and therefore easy to

110 is one of the most favoured choices for next-generation Li batteries, especially Li-S and Li-air syst

111 Most next-generation Li ion battery chemistries require a function

112 the existing lithium-ion batteries and next-generation lithium metal batteries.

113 ing, and that the T cell might use its force-generation machinery to probe the mechanical properties

114 Next-generation massive-parallel DNA sequencing (NGS) analysi

115 n engineering is a promising method for next-generation materials processing techniques.

116 Facilitated action potential (AP) generation, measured as higher firing rate, shorter EPSP

117 ntial for both climate change and a shifting generation mix to alter this vulnerability.

118 of Prussian Blue based (bio)sensors in power generation mode are, respectively, even slightly higher

119 abilized in NU-1000 provide an active, first generation MOF-based, selective methane oxidation cataly

120 l describes a unique in vitro method for the generation of a 3D human lymphatic network within native

121 This methodology also involves the generation of a dicentric chromosome intermediate, which

122 he developed platform combines the automatic generation of a drug gradient concentration, allowing ex

123 inetics and emission wavelengths enables the generation of a spatial pattern of fluorescent emission

124 ed and tegumental proteins contribute to the generation of a tumorigenic environment and are targets

125 Here we report the generation of alveolar epithelial type 2 cells (AEC2s),

126 Further, we observed generation of an effective anti-WNV immune response when

127 ion of the complement system with subsequent generation of anaphylatoxins (C3a, C5a) and the terminal

128 Studies show that generation of angiotensin-(1-7) by ACE2 and its binding

129 hosphorylation, increases in substrate level generation of ATP and reducing equivalents, and recyclin

130 onium) binding site, stabilizing the in situ generation of benzhydryl cation and oxonium ion intermed

131 mission in a particulate platform allows the generation of binary temporal codes for efficient data e

132 Activation of MLKL results in the generation of broken, PM "bubbles" with exposed PS that

133 e (KR(0)) domains that are implicated in the generation of C2-epimerized (2S)-2-methyl-3-ketoacyl-ACP

134 d activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme.

135 ia infection is often persistent, leading to generation of CD4 effector and effector memory T cells t

136 ow that the cytokine activin-A instructs the generation of CD4(+) T cells that express the Tr1-cell-a

137 nx3d expression and completely abolished the generation of CD8(+) single-positive thymocytes.

138 A designer Josiphos ligand promotes the generation of chiral benzylic isomers, when combined wit

139 Thus, UNC-45a promotes generation of contractile actomyosin bundles through syn

140 However, generation of datasets from large, complex genomes has b

141 an vary between plant species leading to the generation of datasets which are difficult to compare.

142 ropism with cells and proteins and the newer generation of delivery strategies that exploits these en

143 has the potential to pave the way for a new generation of digital immunoassays.

144 formed along the on-pathway, suggesting the generation of distinct conformeric strains of Abeta, whi

145 excitation rates than the wild-type, and the generation of early-after-depolarisations promoted unidi

146 try seen in nature is inspiring for the next generation of eco-friendly nanochemistry.

147 The research of a generation of ecologists was catalysed by the recognitio

148 e MAVS signaling pathway is not required for generation of effective immunity.

149 logic circuits to stimulate a transformative generation of energy-efficient computing.

150 ividual importance of these pathways for the generation of essential sphingolipids in differentiated

151 tion factors Ascl1 and Dlx2 (AD) induces the generation of exclusively GABAergic neurons from human P

152 Here, we report on the generation of extreme-ultraviolet optical vortices with

153 up promising avenues in the design of a new generation of FA assays.

154 ocyte complex formation and markedly reduced generation of factor Xa and thrombin on platelets.

155 h17 cell differentiation while promoting the generation of Foxp3(+) regulatory T cells (Tregs).

156 conserved VSG 3'UTR 16-mer sequences for the generation of functional levels of VSG expression in blo

157 ly on the biological effects of Runx1 in the generation of hematopoietic stem cells.

158 n, but how regulation is contained to ensure generation of high-affinity antibody is unknown.

159 s membrane fusion and that Yop1p favours the generation of highly curved membrane structures.

160 ed more attention in recent years due to the generation of highly reactive and selective sulfate radi

161 Herein, we report the simple solution-phase generation of highly reactive phosphaborenes, RP=BR, and

162 ay serve as a suitable platform for the xeno-generation of human tissues and organs in pigs.

163 The generation of hydrogen from water and sunlight offers a

164 been proposed, including thiol depletion and generation of hydrogen peroxide and superoxide, but none

165 nding of molecular mechanisms allows for the generation of hypotheses about the evolution of neural a

166 Here, we report the generation of induced neuron-based model of sporadic Alz

167 AhR antagonist greatly enhanced the in vitro generation of inducible Treg (iTreg) cells from naive CD

168 olesterol conversion enzyme, resulted in the generation of infectious extracellular virions (HSV(des)

169 nificantly reduced phage replication and the generation of infectious particles.

170 Endogenous generation of interstrand cross-links in genomic DNA may

171 d of killing cells, caspases now promote the generation of intra- and extracellular reactive oxygen s

172 ine method, is intrinsically affected by the generation of Joule heating, entailing a drop in viscosi

173 L1 and Reelin as well as the Reelin-mediated generation of L1-80 contribute to brain development at e

174 it a partial gain-of-function phenotype with generation of mechanically activated currents that inact

175 The generation of membrane microtears upon ablation is consi

176 ion Sequencing technologies have enabled the generation of millions of sequences from microorganisms.

177 n cellular reprogramming and facilitates the generation of more robust induced pluripotent stem cells

178 ing mutations in the CHMP2B gene lead to the generation of mutant C-terminally truncated CHMP2B.

179 hermore, the inhibition of EMT prevented the generation of myofibroblasts and production of ECM prote

180 provides insights for the design of the next-generation of nanoscale drug delivery systems.

181 hotspot saturation but also demonstrate that generation of new SHM hotspots and saturation of existin

182 The reaction proceeds via the generation of NHC-bound enolate intermediates formed fro

183 rials as it is a promising fuel for the next generation of nuclear reactors.

184 ency of targeted mutagenesis and the adverse generation of off-target mutations vary greatly between

185 These include enhanced functional studies, generation of oncolytic virus vectors, development of de

186 Based on the generation of Panx3(-/-); Cx43(-/-) mice, Panx3 is upstr

187 lentil fermentation and study its effects on generation of peptides, soluble phenolics and bioactivit

188 The third generation of photovoltaic technology aims to reduce the

189 dies have led to the identification of a new generation of potent broadly neutralizing antibodies (bN

190 to naive astrocyte cultures, indicating the generation of prion infectivity in vitro.

191 reated as an empirical-based approach to the generation of protein CD spectra from atomic coordinates

192 ptional regulator Runx1 is essential for the generation of ROR-gammat expressing iNKT17 cells.

193 sed autophagy, indicating that the increased generation of ROS was associated with the palmitic acid-

194 nanoscale cloth will provide access to a new generation of smart, multifunctional materials, coatings

195 ivotal element in the (photo)electrochemical generation of solar fuels.

196 ion of GvHD by AzaC, instead focusing on the generation of suppressive Tregs (CD4(+)CD25(+)FOXP3(+))

197 x exhibited superior performance towards the generation of syn 2,5-disubstituted pyrrolidines with hi

198 and bacterial infections caused by impaired generation of TH17 cells; meanwhile, some patients with

199 Generation of the CARS signal is optimized for water ima

200 in mice causes myocardial dysfunction after generation of the complement anaphylatoxin, complement c

201 nowledge on the role of sensory input in the generation of the neural drive to muscles and provide th

202 e lifetime limit, which is promising towards generation of transform-limited single photons.

203 strointestinal tract is deficient in de novo generation of Treg cells in allergic mice.

204 The heralded generation of two copies of a remote entangled state is

205 maintains its perennial growth habit through generation of underground adventitious buds (UABs) on th

206 oaches that target several Ags may limit the generation of viral escape mutants.

207 icrofluidics with orthogonal systems and the generation of well-defined microenvironments can be used

208 Hence, future generations of catalysts must perform at temperatures th

209 cell division, which enables tagging several generations of cells.

210 spread of infection to data on the sizes and generations of chains of transmission, respectively.

211 We anticipate that future generations of programmable molecular machines may have

212 sions, CRAF fusions are unresponsive to both generations of RAFi, vemurafenib and PLX8394, highlighti

213 s, 100% of the observed photochemical Fe(II) generation on Fe(III) reduction occurs via a LMCT pathwa

214 oth strategies lasted more than 500 mosquito generations (or about 40 years) in 24% of runs, while in

215 s of a comparative analysis of the frequency generation performance as a function of the input pump p

216 t may promote it, its relationship to within-generation plasticity (WGP) and its role in evolutionary

217 key technology that intended to develop next generation point-of-care (POC) detection system.

218 are often operationally referred to as next-generation probiotics, a concept that overlaps with the

219 ements of prion seeding activity with second-generation real-time quaking-induced conversion (RT-QuIC

220 sogenic iPSCs and found that blockade of p25 generation reduced levels of phosphorylated tau and incr

221 erent physical separation between the plasma generation region and downstream point of application re

222 eed, following haplotypes from generation to generation requires excessive scrolling back and forth.

223 studies facilitated by photochemical radical generation reveal that Y731 changes conformation on the

224 Using next-generation RNA sequencing (RNAseq), we found that host-d

225 Next-generation RNA sequencing and DNA methylation data were

226 limbs at embryonic day 12.5 followed by next-generation sequencing (ChIP-seq).

227 We used Next Generation Sequencing (NGS) and CLC Genomics Workbench t

228 Next-generation sequencing (NGS) approaches are commonly used

229 rpose of this study was to test whether next-generation sequencing (NGS) can be a solution for the au

230 Next-generation sequencing (NGS) can overcome some of these p

231 assembly of whole genome shotgun (WGS) next-generation sequencing (NGS) data benefits from high-qual

232 data but utilization of microarray and next generation sequencing (NGS) data for analysis can be dif

233 tome profiling of plasma-derived EVs by next generation sequencing (NGS) from limited quantities of p

234 ding of DNA template molecules early in next-generation sequencing (NGS) library construction provide

235 ned description of genomic variation in Next Generation Sequencing (NGS) results.

236 uce this overflow of false positives in next-generation sequencing (NGS) screens, we developed DOMINO

237 Advances in next-generation sequencing (NGS) technologies allow comprehen

238 ng a compartmented platform followed by next-generation sequencing (NGS) technology, we find that RNA

239 rase, followed by PCR amplification and next-generation sequencing (NGS) to generate genome-wide repa

240 We combine next generation sequencing (NGS), capillary electrophoresis a

241 Using a next-generation sequencing (NGS)-powered genomic scan, we sho

242 al genomes (NIKS16) were compared using next-generation sequencing (RNA-Seq).

243 Next-generation sequencing analysis of chromosomal copy numbe

244 s and GenBoard enable broad adoption of next generation sequencing based inquiries by the Dictyosteli

245 Analysis of next-generation sequencing data often results in a list of ge

246 cate deletions at base pair level using next-generation sequencing data.

247 patient-specific tumor neoantigens from next generation sequencing data.

248 Next-generation sequencing has revealed recurring somatic mut

249 Although next-generation sequencing has revolutionized the ability to

250 Next-generation sequencing has substantially enhanced our und

251 Advances in genome profiling and next-generation sequencing have led to the classification of

252 Next generation sequencing of Kupffer cell miRNA identified m

253 Our next generation sequencing panel incorporated 38 inherited ar

254 Next generation sequencing provides a count of RNA molecules

255 reaction, to check for concordance with next-generation sequencing results.

256 We used next-generation sequencing techniques to examine chromosomal

257 Advances in Next Generation Sequencing technologies have enabled the gene

258 Next-generation sequencing technologies have greatly increase

259 breakthroughs in molecular biology and next generation sequencing technologies have led to the expen

260 The advent of high-throughput next generation sequencing technology has greatly promoted th

261 r germ line and somatic mutations using next-generation sequencing technology.

262 same fibroblast population and applied next-generation sequencing to compare genomic variations in t

263 genome-wide transcription and repair by next-generation sequencing, we identified locations of elonga

264 to quantify errors in synthetic DNA by next-generation sequencing.

265 in 25 cancer susceptibility genes using next-generation sequencing.

266 ome-wide chemical mutagenesis allied to next-generation sequencing.

267 cation of each mutant's abundance using next-generation sequencing.

268 at this strategy might prove useful for next generation sequencing.

269 methylation patterns were visualized by Next Generation Sequencing.

270 us methods have been developed to mine "next-generation" sequencing (NGS) data to detect deletions an

271 we experimentally demonstrate the deep-UV SH generations (SHGs) by combined degenerate four-wave mixi

272 ptional response of B-ALL to GCs with a next-generation short hairpin RNA screen to identify GC-regul

273 valence of H. pylori infection in successive generations should be weighed in future gastric cancer c

274 d CO2 (1000 muatm, HCL, pHT : 7.70) for 1860 generations, showed significant differences in photosynt

275 the catalytic activity of CK2 using the next-generation small molecule inhibitor CX-4945 in vitro sig

276 We also combine second-harmonic generation spectroscopy with polarization-resolved Raman

277 G protein-coupled receptors (GPCRs), as next-generation targets.

278 -tracking, precision-hold, and maximum force-generation tasks, with each hand.

279 encing on six out of nine members in a three-generation TD multiplex family.

280 ied DNA triggered contact-dependent thrombin generation (TG) and amplified TG initiated by low concen

281 tter co-catalyst for photocatalytic hydrogen generation than the precious metal.

282 e Cycle Assessment of coal-fired electricity generation that compares monoethanolamine (MEA)-based po

283 cial nonlinearity probed via second harmonic generation that is sufficient to achieve d33>10 pm V(-1)

284 the need for external power supply or signal generation, the all-optical simplicity of virtual-electr

285 Significantly, at the steady state of power generation, the EFC device with RVC-Au electrodes provid

286 ntage of the spatial-temporal control of ROS generation, the meticulous participation of light, photo

287 ut little is known about the kinetics of the generation, the tissue distribution or the underlying me

288 uction is possible prior to hydroxide eluent generation, this configuration causes complications beca

289 r nanorods allow both efficient photocurrent generation through a photovoltaic response and electrolu

290 nd maintained near-perfect isolation over 25 generations through strong ancestry-assortative mating.

291 enetic underpinnings of longevity, since its generation time is brief and both the genetic background

292 Evidently, discordance is a product of long generation times and moderately large effective populati

293 nt potential as an in situ method for oxygen generation to enhance the efficacy of treatments that de

294 Indeed, following haplotypes from generation to generation requires excessive scrolling ba

295 umber of studies show that plasticity across generations (transgenerational plasticity or TGP) may oc

296 Human PET imaging using the second-generation TSPO radiotracer [(11)C]DPA-713 revealed a st

297 offspring, suggesting that changes in the F1 generation were related to in utero somatic reprogrammin

298 oskeletal networks plays a key role in force generation, while on the tissue level the spatial organi

299 e molecular characteristics of CM using next-generation whole-exome sequencing (WES).

300 A critical determinant of Cr(VI) generation within soils and sediments is the necessary i