ライフサイエンスコーパス: genetic background

1 tially affect bacterial fitness depending on genetic background.

2 ities, whereas LV progression is modified by genetic background.

3 ncerous, and metastatic cells, with the same genetic background.

4 rong interactions between mutant alleles and genetic background.

5 rent neurological outcomes depending on host genetic background.

6 s in other species because of differences in genetic background.

7 le expressivity are common even on a defined genetic background.

8 to mammary carcinomas from mice of different genetic background.

9 served retained universality with respect to genetic background.

10 nd the effects were further modified by host genetic background.

11 urvival, irrespective of tissue of origin or genetic background.

12 (ZH3) Prnp-ablated allele on a pure C57BL/6J genetic background.

13 c3r KO, Mc4r KO and DKO rats on a homogenous genetic background.

14 mino acid mutations are often conditional on genetic background.

15 function pathologies or have a heterogeneous genetic background.

16 ppears to be independent of the LOAD-related genetic background.

17 to be heritable traits with possible shared genetic background.

18 Mx1 protective function is influenced by the genetic background.

19 acy in mice expressing SOD1(G93A) on a mixed genetic background.

20 o study the effects of a mutation in a fixed genetic background.

21 a single locus, together with changes in the genetic background.

22 DiCre-expressing P. falciparum lines in any genetic background.

23 alomyelitis (EAE) in mice with a susceptible genetic background.

24 o fibroblasts, derived from mice of the same genetic background.

25 rom a Lewis rat was introgressed onto the SS genetic background.

26 role of NKT cells was dependent on the host genetic background.

27 um pathotypes 1, 2, 6 and 18 in the analyzed genetic background.

28 ferential effect on the 2 sexes, acting on a genetic background.

29 local colonic environment and the patient's genetic background.

30 f photoreceptors involved with heterogeneous genetic background.

31 ietary factors are acting upon a preexisting genetic background.

32 large domain of familial cancer with unknown genetic background.

33 S. aureus bacteremia isolates from the same genetic background.

34 sion, possibly due to its fibrosis-resistant genetic background.

35 SA300 methicillin-resistant S. aureus (MRSA) genetic background.

36 e disease that can be fatal depending on the genetic background.

37 clinical syndromes) without regard for their genetic background.

38 veolar macrophages was also dependent on the genetic background.

39 that the extent of protection may depend on genetic background.

40 anner, and its function is dependent on host genetic background.

41 a would show adaptation to a particular host genetic background.

42 otypic features in Scn2a(Q54) mice depend on genetic background.

43 dontitis in young patients with predisposing genetic background.

44 rol of effects from other covariates such as genetic background.

45 sorder (MDD) have high morbidity and share a genetic background.

46 es embryonic lethality in mice with a hybrid genetic background.

47 some test parameters dependent on gender and genetic background.

48 largely by the number of founders and their genetic background.

49 -like disease in mice with an IL-6-deficient genetic background.

50 a pathogenic mutation across a wide range of genetic backgrounds.

51 ant gamma2 subunit, in addition to different genetic backgrounds.

52 of these TCRs in HIV controllers of diverse genetic backgrounds.

53 ill even highly resistant B-ALL with diverse genetic backgrounds.

54 are unconditionally acceptable in divergent genetic backgrounds.

55 me-wide programmable gene repression in many genetic backgrounds.

56 interactions were influenced by the parasite genetic backgrounds.

57 ic muscle disease in the mdx or Sgcd(-/-) MD genetic backgrounds.

58 lele loss or silencing in cells with defined genetic backgrounds.

59 diac or muscle function, when studied on two genetic backgrounds.

60 in both male and female mice of two distinct genetic backgrounds.

61 als from different transmission settings and genetic backgrounds.

62 obioticum varies therefore between different genetic backgrounds.

63 ed among many individuals with heterogeneous genetic backgrounds.

64 of sensitivity to SN30000 in three different genetic backgrounds.

65 achieve the biofilm phenotype with different genetic backgrounds.

66 or screens in the chs3-2D and chs3-2D pad4-1 genetic backgrounds.

67 o act on genes that have evolved in multiple genetic backgrounds.

68 he phenotypic outcomes in various sensitized genetic backgrounds.

69 across diverse environmental conditions and genetic backgrounds.

70 ermination in both early- and late-flowering genetic backgrounds.

71 observed even among patients from different genetic backgrounds.

72 mouse strains and mutations placed on inbred genetic backgrounds.

73 ows the apomictic allele to spread onto many genetic backgrounds.

74 ould be selected in individuals with diverse genetic backgrounds.

75 clude that, in a controlled environment, the genetic background accounts for a substantial fraction o

76 notype and phenotype, the variability in the genetic backgrounds across populations, and the genomic

77 how that both pneumococcal serotype and host genetic background affect the development of disease and

78 It is unclear to what extent an individual's genetic background affects the characteristics of the an

79 of gene clusters that co-vary over different genetic backgrounds, among others a cluster of genes wit

80 ogenetic = 0.748), which indicates a similar genetic background and allowed us to identify four addit

81 works whose structure and function vary with genetic background and argue that these effects can be e

82 pattern in Cux2-Cre/CreERT2 mice depends on genetic background and breeding strategies.

83 e of NFS2 in symbiosis is contingent on host genetic background and can be counteracted by other gene

84 ctors can contribute to pathology, including genetic background and differential expression of transg

85 respect to geographical point of isolation, genetic background and drug resistance, the patterns for

86 n evolutionary process that is influenced by genetic background and environment.

87 t in the context of identical constitutional genetic background and environmental exposure, different

88 population of parasites (1-30%, depending on genetic background and growth conditions).

89 individual ATP7A/B mutations in an invariant genetic background and has the potential to be used to s

90 nd on important interactions with the host's genetic background and inflammatory potential.

91 ription factors (TFs) is highly dependent on genetic background and interactions with cofactors.

92 re in endometrial cancer risk with regard to genetic background and lifestyle features.

93 increases soybean protein independent of the genetic background and original protein content of the c

94 ce its generation time is brief and both the genetic background and rearing environment can be precis

95 To explore whether genetic background and sex determine glomerular ECM comp

96 ies suggest that patients with a susceptible genetic background and some stimulus, such as barrier di

97 ditional gene ablation while controlling for genetic background and tamoxifen effects.

98 mice we were able to dissect the impacts of genetic background and the degenerative process on DAC s

99 of ZBED6 on tumor development depends on the genetic background and the transcriptional state of its

100 e, especially those relevant to selection of genetic background and those that might inadvertently be

101 s is challenging due to inability to control genetic background and variation in histories of environ

102 lergens in mice was highly dependent on host genetic background and was associated with oxidative str

103 Impaired regeneration was dependent on genetic background and was observed when partial reducti

104 These results show that genetic background and/or environment can influence the

105 evolution of enhanced biofilm from different genetic backgrounds and a possible role in colonization

106 mice up to 2 years of age in three different genetic backgrounds and characterized them with respect

107 xity of HTS-induced responses over different genetic backgrounds and connectivity of adaptive mechani

108 gue mosquito Ae. aegypti displaying distinct genetic backgrounds and contrasted resistance levels to

109 1 was consistently detected across different genetic backgrounds and could be an important source for

110 Phenotypes are rarely consistent across genetic backgrounds and environments, but instead vary i

111 t bacterial population structure streamlined genetic backgrounds and established cross schemes to add

112 of nephron reduction in mice from different genetic backgrounds and genetically modified animals wit

113 eatures and allows the analysis of different genetic backgrounds and mutations during the course of t

114 ot be reliably inferred by studying a single genetic background, and thus constitute a major challeng

115 oughout multiple time points, using multiple genetic backgrounds, and multiple omics approaches (tran

116 C57BL/6J, CD-1, FVB/NCr1, and 129S2/SvPasCrl genetic backgrounds, and of two additional alleles, HttQ

117 blast patterning was observed across diverse genetic backgrounds, and the analysis of genetic pattern

118 different K. pneumoniae strains that vary in genetic background, antibiotic susceptibility, capsule c

119 mutant fish can be quickly replicated in any genetic background anywhere in the world.

120 d generating the pss1 mutation in the pen1-1 genetic background as well as genetic mapping and charac

121 stry, has been deleterious on a modern human genetic background, as reflected by its depletion near g

122 onses, several observations support a shared genetic background between AA and atopy.

123 This study highlights the shared genetic background between childhood and adult body mass

124 e differences in environmental exposures and genetic background between Chinese and European populati

125 Exploitation of differential p53 genetic backgrounds between human hematopoietic and colo

126 species with populations that share a common genetic background but blood feed in one region and are

127 utants were attenuated only in the wild-type genetic background but not in the ComX-null background,

128 lted in synergies across a broad spectrum of genetic backgrounds but often yielded only cytostatic re

129 , we address the importance of the metabolic-genetic background by monitoring transcriptome, proteome

130 oph vaccine strains in the type II Deltaku80 genetic background by targeting the deletion of the orot

131 argeting of VHL-deficient CC-RCC in multiple genetic backgrounds by clonogenic assays.

132 equent in Latino population, suggesting that genetic background can alter its effects on phenotype.

133 Intriguingly, some D. melanogaster nuclear genetic backgrounds can fully rescue COII(G177S) -associ

134 ons were introduced into an oxidative stress genetic background (cat2), the dhar1 dhar2 combination d

135 ly deleterious alleles become favored as the genetic background changes.

136 Cs from monozygotic twins to investigate how genetic background, clone, and passage number contribute

137 When the mutations were in the DeltarcrR-NP genetic background, ComX production and transformation w

138 While the parasite genetic background consistently impacts most of these pa

139 identified, it is unknown how much the host genetic background contributes to interindividual differ

140 A possible common genetic background could explain the coexistence of thes

141 While in the DeltaveA genetic background cpsA deletion restores ST production,

142 d mutations in human neurons on a controlled genetic background, demonstrate that partial STXBP1 loss

143 Thus EGR1, in a genetic background-dependent manner, plays a critical ro

144 small fraction of a population with similar genetic background deteriorates into mental disorders.

145 The response is consistent across genetic backgrounds, developmental stages, and parasite

146 iscuss the role of hepatic lipid metabolism, genetic background, diet, and physical activity on fatty

147 m a single genotype and shows that different genetic backgrounds differ dramatically in their propens

148 al and epigenetic variation originating from genetic background dominates over variation due to cellu

149 D. mauritiana segment and the grandparental genetic background donating the chromosomes.

150 g Tn mutant libraries generated in different genetic backgrounds (e.g. wild-type strain versus knocko

151 and allow a global, better interpretation of genetic background effects and a source of naturally def

152 Genetic background effects have long been recognized and

153 These genetic background effects often result from the action

154 g MC-associated disease needs to incorporate genetic background effects, which can yield drug resista

155 status, sex, cell or tissue type, ancestry, genetic background, experimental stimulus, or technical

156 Although a number of causative genetic backgrounds for tumor development have been disc

157 diversity, we used mouse strains of diverse genetic backgrounds, from different providers, kept in d

158 utants form stomata in the dark, and in this genetic background, GATA expression is sufficient to ind

159 is dependent on specific Aire mutations and genetic background genes.

160 ocula to newly emerged worker bees from four genetic backgrounds (GH) and reared them in normal (with

161 The important effect that genetic background has on the inner ear phenotype of Atp

162 length of the CAG expansion, factors such as genetic background have been shown to contribute to the

163 the type of RET gene mutation and the cancer genetic background (hereditary vs sporadic).

164 e as measured by educational attainment) and genetic background (i.e. TMEM106B polymorphism, rs199062

165 linkage to the female sex, occurs in a male genetic background (i.e., lacking the ancestral W female

166 redict cardiotoxicity: i) cells with a human genetic background; ii) physiologically relevant tissue

167 strate the power of CC mice for studying the genetic background impact between comorbidity of t2DM an

168 However, the high variability of genetic background in human populations hampers the repr

169 ated inflammatory skin disease with a strong genetic background in which activation of IL-17 signalin

170 ment, we established an Arabidopsis thaliana genetic background in which fundamental patterning proce

171 mutation depends on its interaction with the genetic background in which it is assessed.

172 of new mutations and their dependency on the genetic background in which they occur.

173 aits, with universal applications under wide genetic backgrounds in crops.

174 Further, in genetic backgrounds in which the leg primordia are absen

175 hereas secondary HLH occurs, without a known genetic background, in a context of infections, malignan

176 We introduced individuals from three genetic backgrounds (inbred - outbred) into a novel envi

177 E from the Brown Norway (BN) rat onto the SS genetic background increased renal 20-HETE levels after

178 ss, immune-compromised flies resembled their genetic background, indicating that familial transmissio

179 at the phenotype develops in a loricrin-null genetic background, indicating that suppressed suprabasa

180 However, host and pathogen genetic backgrounds influence cytokine production, makin

181 To shed light onto the genetic background influencing susceptibility for GCA, w

182 These observations demonstrate that the genetic background is very important for the protective

183 particularly in patients with different BRAF genetic backgrounds, is unclear.

184 c day 7.5 (E7.5) embryos in the C57BL6 mouse genetic background led to defective fetal erythropoiesis

185 studies will elucidate interactions between genetic background, lifestyle, and environmental factors

186 o inbred lines of chicken differing in their genetic background , Lines 0 and C-B12, were respectivel

187 ur findings demonstrate an important role of genetic background, lymphocytes, and cytokine signaling

188 of miR-181a expression in the ABC-like DLBCL genetic background may result in a significant change in

189 NKT cell number and function among different genetic backgrounds may be an important contributor to i

190 s that promote healthy ageing across diverse genetic backgrounds may engage conserved longevity pathw

191 train is the more logical and representative genetic background model for metabolic studies.

192 tein mutations in progenitor D39 and related genetic backgrounds; nor is GpsB required for StkP local

193 t that higher blood pressure depends on both genetic background (NOS3 deficiency) and uterine environ

194 d at a high prevalence but most often with a genetic background not associated with a clinical infect

195 step to perform when assessing the extent of genetic background of a disease.

196 l from diverse sources and assessment of how genetic background of a mouse strain influences the biol

197 These mutations were identified in the genetic background of an H5 HA protein that was mutated

198 ough there is considerable research into the genetic background of autism spectrum disorders, environ

199 AhRR-transgenic mice (AhRR Tg) based on the genetic background of C57BL/6J wild type (wt) mice.

200 ng a low-fusion, subgroup B F protein in the genetic background of codon-deoptimized nonstructural pr

201 germplasm or older improved varieties to the genetic background of contemporary improved cultivars.

202 Our results provide new insights into genetic background of craniofacial microsomia.

203 nly a few genes have been uncovered, and the genetic background of CVID remains elusive to date for t

204 nstrated that both the culture technique and genetic background of donor plants affected tissue cultu

205 Our findings indicate that the genetic background of hyperglycemia is unrecognized in t

206 im of this study is to determine whether the genetic background of initial periodontitis and caries c

207 from Spain to provide further context on the genetic background of Mesolithic Europe.

208 highlight the importance of considering the genetic background of patients with ALS when analyzing t

209 To decipher the genetic background of plasma adiponectin levels, we perf

210 These results provide novel insight into the genetic background of polyunsaturated fatty acids and th

211 er understand how domestication modifies the genetic background of populations, and how it may alter

212 F has tumour suppressor activity in the same genetic background of Pten loss that yields oncogenic ac

213 reast cancers, possibly indicating disparate genetic background of screen-detected breast cancers and

214 hybrid male sterility when homozygous in the genetic background of sibling species Drosophila simulan

215 Moreover, in a similar genetic background of silenced PKM1 or PKM2, the knockin

216 inding based either on parental origin or on genetic background of the allele.

217 ings in mice highlight the importance of the genetic background of the host and could be relevant for

218 om, the frequency of venom exposure, and the genetic background of the host.

219 ndent on a variety of factors, including the genetic background of the host.

220 n the strain of the virus and on the age and genetic background of the host.

221 incorporated a luciferase-based tag into the genetic background of the KPC mouse model.

222 dependent on specific Aire mutations and the genetic background of the mice.

223 urvival in heritable retinoblastoma, and the genetic background of the patient influences choice of e

224 mor cell plasticity, which-together with the genetic background of the tumor-determines whether cells

225 Thus, the genetic backgrounds of C. heterostrophus and U. botrytis

226 alling networks-and interacts with different genetic backgrounds of co-occurring alterations-in diffe

227 rol resistance to S. endobioticum in various genetic backgrounds of potato.

228 There was a significant difference in the genetic backgrounds of S. aureus colonizing AE cases ver

229 mouse population for studying the impact of genetic background on comorbidity of alveolar bone chang

230 1, in order to assess the influence of their genetic background on GC-induced osteoporosis (GIO).

231 end previous studies comparing the effect of genetic background on the AS phenotype by investigating

232 r results also demonstrated the influence of genetic background on the expression of cold and floweri

233 While the effects of species and genetic background on these phenotypes remain difficult

234 n researchers do not factor in the effect of genetic background on tumor biology.

235 mdr2 and crt polymorphisms are markers of a genetic background on which kelch13 mutations are partic

236 ated the impact of the host and pneumococcal genetic backgrounds on pulmonary cytokine responses and

237 These findings indicate the effect of common genetic backgrounds on the Ube3a maternal deletion behav

238 All other variables like diet, age, genetic background, physiological status and original gu

239 A key result was that host genetic background plays a more important role in shapin

240 time traits using an extremely large multi- genetic background population that contained more than 8

241 microbiome composition is influenced by host genetic background, potentially cariogenic taxa are like

242 Analyses revealed that individuals with a genetic background predicting relatively high anandamide

243 ow similar biological effects, regardless of genetic background, prevalence of the cognate T-cell pop

244 hesized that hepatocyte culture duration and genetic background regulate hepatocyte susceptibility to

245 cannabis use are more evident on a specific genetic background related to its receptor expression.

246 Here, 11 diverse species of yeasts with genetic backgrounds representative of different branches

247 become differentially expressed on XX and XY genetic backgrounds respectively.

248 g how brain cells derived from diverse human genetic backgrounds respond to specific drugs, creating

249 ession, the Ctss gene was deleted in the mdx genetic background, resulting in protection from muscula

250 endent saddle pattern mutants from different genetic backgrounds revealed independent lesions affecti

251 ed genes between the winter and spring wheat genetic backgrounds showed a striking pattern of biased

252 CAF-1 function (segregated from a fas1xfas2 genetic background) showing major rDNA rearrangements.

253 Genetic background significantly affects phenotype in mu

254 he Maasai, an East African population with a genetic background similar to that of Gambians but with

255 enotype may be sensitive to small changes in genetic background, so that results from phenotypic scre

256 Genetic background-specific sequence differences also in

257 ies of experiments to examine the effects of genetic background (strain), voluntary exercise (wheel r

258 erent sleep intensity profiles among related genetic background strains previously assumed to have eq

259 Genetic background strongly influenced the magnitude and

260 mental settings and used them to examine how genetic background, such as that of Black and Tan Brachy

261 e same level in both wild-type and ComX-null genetic backgrounds, suggesting that the constitutive ba

262 of CRY2 on thermal response are dependent on genetic background suggestive of the presence of modifie

263 18 and SpDbr1 (lariat debranching enzyme), a genetic background suitable for detection of lariat RNAs

264 r deleterious effect in rodents of different genetic background, supporting the merit of anti-GRP78 d

265 onic stem cell line with an FSGS-susceptible genetic background that allows shRNA-mediated targeting

266 o For example, mice in the resistant C57BL/6 genetic background that are triple-deficient for TLR3, -

267 Our results indicate that a genetic background that favors longer telomere length ma

268 We found extremely strong interactions with genetic background that sometimes supported diametricall

269 ts were carried out in live, intact flies in genetic backgrounds that increased or decreased the forc

270 mouse models of DMD, which are on different genetic backgrounds, the C57BL/10ScSn-Dmdmdx (B10-mdx) a

271 ranscriptomics data across environmental and genetic backgrounds, the systems biology core proteome i

272 rossing this Pkhd1 mutation onto the C57BL/6 genetic background; thus, the NOD genetic background (wh

273 Researchers should embrace differences in genetic background to build richer disease models that m

274 tion of individual risk variants and complex genetic background to human pathology.

275 To establish the contribution of the genetic background to phenotypic variability associated

276 Sendai virus (SeV) reprogramming method and genetic background to transcriptional and DNA methylatio

277 erated a total of 24 mutants in type 1 and 2 genetic backgrounds to ascertain the functions of noncan

278 xistence of a robust response over different genetic backgrounds to mild drought stress in developing

279 hybrids, used to separate Eda genotype from genetic background, to contrasting conditions in semi-na

280 eries of 12 PHEO/PGL patients with different genetic backgrounds, to compare (18)F-FLT uptake with (1

281 n the mutation is propagated on the C57/BL6J genetic background, total fat mass rises significantly w

282 ne expression levels are also similar across genetic backgrounds (two times higher Spearman rank corr

283 entifies known phenotypes for a diversity of genetic backgrounds under cyclohexamide stress and also

284 ne pool, and ascorbate depletion in a cat2-2 genetic background upon exposure to photorespiratory str

285 Our data further imply that genetic background variation is a major confounding fact

286 sing full- and half-sibling sets matched for genetic background, we found replicated evidence that (i

287 under conditions that precisely control for genetic background, we generated human ESCs with differe

288 As CSC and non-CSC share an identical genetic background, we hypothesize that differences in e

289 s that change among most mutants and in both genetic backgrounds, we found that rifampin resistance m

290 However, MIP-CreERT mice on different genetic backgrounds were protected from high-fat/ strept

291 se dNTP imbalances are strongly mutagenic in genetic backgrounds where DNA polymerase function or MMR

292 he C57BL/6 genetic background; thus, the NOD genetic background (which promotes autoimmunity) is esse

293 SCN of three genetic backgrounds-wild-type, short-period CK1epsilon(T

294 icrobiota readily distinguishable from their genetic background with the introduction and establishme

295 (Lonchura striata domestica) from different genetic backgrounds with synthetic songs in which tempo

296 person's BMI is expected to differ, based on genetic background (with respect to these 29 loci), from

297 ) isolates have revealed a wide diversity of genetic backgrounds, with only sporadic occurrence of ST

298 othelial cells having distinct mitochondrial genetic backgrounds would show variation in mitochondria

299 In certain genetic backgrounds, WT mice show a greater incidence of

300 We found that, depending on their genetic background, young flies had microbiota of differ