ライフサイエンスコーパス: genetic determinant

1 apping QTLs and identifying their underlying genetic determinants.

2 size, lipid composition, gene expression and genetic determinants.

3 bout global variation in translation and its genetic determinants.

4 nderstanding of disease mechanisms and their genetic determinants.

5 related strains to identify the responsible genetic determinants.

6 ively little is known about their underlying genetic determinants.

7 amilial aggregation in humans and likely has genetic determinants.

8 dox) points to the concomitant importance of genetic determinants.

9 al variability, which is explained partly by genetic determinants.

10 OPD) is linked to both cigarette smoking and genetic determinants.

11 x thrombotic disorder with environmental and genetic determinants.

12 agnoses within families suggests overlapping genetic determinants across psychoses.

13 The same genetic determinant also affects the sensitivity of thes

14 Previous studies have revealed shared genetic determinants among different inflammatory disord

15 evels of lipids and lipoproteins have strong genetic determinants and are recognized as key risk fact

16 minative models which integrate knowledge of genetic determinants and biologic processes governing bo

17 ve as a complementary phenotype to study the genetic determinants and clinical relevance of brain str

18 le to the robust discovery and validation of genetic determinants and gene expression signatures of v

19 To identify genetic determinants and mechanisms underlying MetS, an

20 tand its epidemiology, antibiotic resistance genetic determinants and potential virulence factors.

21 The underlying genetic determinants are beginning to emerge and are int

22 However, the underlying genetic determinants are largely unknown.

23 ma and during cardiovascular stress, yet the genetic determinants are poorly understood.

24 n the nose, numerous signaling molecules and genetic determinants are required in concert to generate

25 However, the underlying genetic determinants are unclear.

26 e allergy is influenced by environmental and genetic determinants, as illustrated by differences in w

27 , and addresses the increasing importance of genetic determinants, as well as practical aspects of di

28 ion and functional characterization of viral genetic determinants associated with AHF and Candid #1 a

29 l factors the search continues not only into genetic determinants but also extrinsic influences and t

30 nce have indicated that both genetic and non-genetic determinants can contribute to intra-tumor heter

31 that support cancer pathophysiology, but the genetic determinants conferring sensitivity to NAE inhib

32 ion and functional characterization of viral genetic determinants dictating JUNV virulence or attenua

33 inflammation due to a complex interaction of genetic determinants, disruption of mucosal barriers, ab

34 the gam-cII region of phage Phi8 might carry genetic determinants downregulating the transcription of

35 ed that this gene is a potentially important genetic determinant for ALL susceptibility.

36 l-pump gene Heavy Metal ATPase4 as the major genetic determinant for Cd tolerance.

37 ded nonstructural 2 (NS2) protein as a viral genetic determinant for initiating RSV-induced distal ai

38 While this locus represents the strongest genetic determinant for T2D risk in humans, it remains u

39 These data reveal sex-specific genetic determinants for aortic pulse wave velocity and

40 Genetic determinants for challenge-proven peanut allergy

41 17q21 gene variants are the strongest known genetic determinants for childhood asthma and have been

42 ng and can be potentially useful to identify genetic determinants for complex disorders.

43 This is the first identification of genetic determinants for E. faecalis commensal and patho

44 his phenotypic diversity is knowledge of the genetic determinants for each trait of interest.

45 Xenosphere CCICs retained the genetic determinants for EGFR therapeutic response in vi

46 summary, we identified multiple independent genetic determinants for Lp(a)-cholesterol.

47 Here, we identified genetic determinants for this epigenetic process and exa

48 In primary microcephaly the genetic determinants frequently involve mutations that c

49 PMD is highly heritable, but few genetic determinants have been identified.

50 While some genetic determinants have been reported, the etiology of

51 laboratory presentation, as well as a common genetic determinant, HLA-DR4, indicating they may be par

52 d Lpl rpoD enables the identification of Lpl genetic determinants imparting strong ethanol tolerance

53 atment of arrhythmias was described, whereas genetic determinants important to the optimal treatment

54 6-phosphate phosphatase gene, OsTPP7, as the genetic determinant in qAG-9-2, a major quantitative tra

55 In this study, we identify a genetic determinant in the viral envelope (N173) that in

56 To identify genetic determinants in lymphatic tissue that critically

57 These findings provide further insight into genetic determinants in NP and M1 involved in PR8 IAV ad

58 ental risk factors, coagulation factors, and genetic determinants in patients with plaster casts lead

59 orporate biological knowledge on the role of genetic determinants in predicting an outcome.

60 MprAB regulates a large and diverse group of genetic determinants in response to membrane stress, inc

61 et little is known about its heritability or genetic determinants in the general population.

62 ntal HCV strain strongly indicate a role for genetic determinants in the host immune response to HCV.

63 e identification and characterization of key genetic determinants in the investigation of biological

64 alysis of the role of serum ferritin and its genetic determinants in the pathogenesis and treatment o

65 h a worse prognosis in patients with IA, and genetic determinants in this subset of patients have not

66 (referred to here as APOE4), as well as non-genetic determinants including ageing.

67 e results support the hypothesis that common genetic determinants influence shared mechanisms of auto

68 This study was aimed at identifying the genetic determinants involved in coaggregation between t

69 ging pathogen, and little is known about the genetic determinants involved in its pathogenesis.

70 riatal mechanisms to ADHD symptoms and their genetic determinants is largely unexplored.

71 structural differences in the amygdala, its genetic determinants, its environmental modulators, and

72 One genetic determinant lies within the major histocompatibi

73 ided the strongest evidence so far of a host genetic determinant linked to HCV clearance.

74 ation of Lp(a) is highly heritable, with its genetic determinants located in the apo(a) locus and reg

75 CD4(+) and CD8(+) T cells, respectively: the genetic determinant maps to the viral envelope.

76 entrations are similar between the 2 groups, genetic determinants may be ethnicity specific.

77 nd suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addit

78 In hypothesizing that additional genetic determinants might direct use of these drugs, we

79 We investigated whether distinct or shared genetic determinants might underlie susceptibility to ar

80 ults define RHPN2 amplification as a central genetic determinant of a highly aggressive phenotype tha

81 lusion, we identified rs41314453 as the main genetic determinant of ADAMTS13 activity, and we present

82 is association and indicates that Nr2f2 is a genetic determinant of blood pressure (BP).

83 ariation in FTO is the most important common genetic determinant of body weight.

84 We tested the effects of a genetic determinant of branched-chain amino acid/aromati

85 Overall, this study identifies a unique genetic determinant of Cd tolerance in the metal hyperac

86 stellate cell activation may be an important genetic determinant of cellular sensitivity to both enzy

87 in the BCAR1-CFDP1-TMEM170A locus as a novel genetic determinant of cIMT and coronary artery disease

88 is study, we aimed to identify the strongest genetic determinant of circulating DMG concentration and

89 demonstrate FBW7 mutational status as a key genetic determinant of CRC response to targeted therapie

90 Furthermore, mutation type may serve as a genetic determinant of deafness, but not cardiac express

91 S, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine ex

92 Our work identifies NPC1 as a genetic determinant of filovirus susceptibility in bats,

93 The HAVCR1 genomic region is an independent genetic determinant of HCV persistence in individuals of

94 The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-A

95 TGFB1 genetic variation may be an important genetic determinant of mammographic density measure that

96 genomic data to identify CDC28 as the major genetic determinant of meiotic and budding cell shape be

97 Taken together, our findings identify a genetic determinant of MxA target recognition and sugges

98 first evidence, to our knowledge, of a host genetic determinant of NTS disease in African children,

99 in both mice and humans, identify Bicc1 as a genetic determinant of osteoblastogenesis and BMD and su

100 LRRK2 (PARK8) is the most common genetic determinant of Parkinson's disease (PD), with do

101 ts implicates the vacuolar ATP synthase as a genetic determinant of resistance to TAPs.

102 The I148M PNPLA3 genotype may represent a genetic determinant of serum adiponectin levels.

103 wn previously that the viral envelope is the genetic determinant of the differential T cell tropism i

104 identified rhophilin 2 (RHPN2) as a central genetic determinant of the mesenchymal phenotype of huma

105 To determine whether LOX is a genetic determinant of the pathogenesis of keratoconus,

106 cohort, thus representing the most frequent genetic determinant of the subtype.

107 than does subtype C, and we identify a major genetic determinant of these differences.

108 ariation within TCF7L2 remains the strongest genetic determinant of type 2 diabetes risk in humans.

109 e-wide association study (GWAS) in search of genetic determinants of a variation in plasma plasminoge

110 The genetic determinants of ADAMTS13 activity remain unclear

111 ve efforts have been devoted to the study of genetic determinants of AF.

112 have proven instrumental in the discovery of genetic determinants of aging, and the fission yeast Sch

113 To further investigate the genetic determinants of AITD, we conducted an associatio

114 Understanding of genetic determinants of allergic disease may lead to nov

115 To identify additional genetic determinants of androgen levels, a GWAS of basel

116 This study aimed to identify novel genetic determinants of AOS.

117 Genetic determinants of arrhythmia susceptibility (such

118 h high heritability, although the underlying genetic determinants of ASDs remain largely unknown.

119 To further investigate the genetic determinants of autoantibody positivity, we perf

120 While genetic determinants of barrier function are important,

121 Even after decades of investigation, the genetic determinants of BAV and its complications remain

122 Genetic determinants of biofilm formation differ between

123 To identify genetic determinants of biofilm formation in M. tubercul

124 squitoes is driven, at least in part, by the genetic determinants of bite reaction size.Our findings

125 rogress has been made toward elucidating the genetic determinants of BMD, our understanding of the fa

126 The genetic determinants of body fat distribution are poorly

127 Caucasians, fewer studies have investigated genetic determinants of body mass index (BMI; weight (kg

128 nematode Caenorhabditis elegans to identify genetic determinants of body size.

129 al insights into the complex relationship of genetic determinants of body weight in the etiology of b

130 Our results suggest that genetic determinants of BP act from childhood, develop o

131 ad literacy is too recent to have influenced genetic determinants of brain organization.

132 major bottleneck in our understanding of the genetic determinants of cancer.

133 These findings suggest that genetic determinants of childhood bone accretion at the

134 To date, large-scale investigations of genetic determinants of cIMT are sparse.

135 o a paucity of adequately sized studies, the genetic determinants of circulating AMH levels are poorl

136 B12 deficiency but little is known about the genetic determinants of circulating B12 concentrations i

137 role of IL-1RA, this study aimed to identify genetic determinants of circulating IL-1RA concentration

138 enome-wide study to report on the underlying genetic determinants of CK variation in a population of

139 The distinctions between genetic determinants of cluster III expression in vitro

140 Genetic determinants of cognition are poorly characteriz

141 The understanding of the genetic determinants of complex disease is undergoing a

142 association study was performed to identify genetic determinants of Cp levels and evaluate their ass

143 mericans than in European Americans, but the genetic determinants of CRP in these admixed United Stat

144 We performed a study to evaluate potential genetic determinants of CRP response using genome-wide g

145 The major genetic determinants of cutaneous melanoma risk in the g

146 -genome approach was used to investigate the genetic determinants of cytarabine-induced cytotoxicity.

147 lity, little success was achieved in mapping genetic determinants of depression-related traits by mea

148 ng individuals in a population to search for genetic determinants of differential gene expression.

149 This review explores phenotypic and genetic determinants of disease progression in ALS, and

150 Host specific genetic determinants of disease severity identified by t

151 have revealed that HLA alleles are the major genetic determinants of drug hypersensitivity; however,

152 We sought to identify genetic determinants of early postnatal eNO levels and s

153 These findings suggest that genetic determinants of eGFR are mediated largely throug

154 ffer important mechanistic insights into the genetic determinants of EGFR gliomagenesis and sensitivi

155 Genetic determinants of elevated circulating myeloperoxi

156 ide from alpha-1 antitrypsin deficiency, the genetic determinants of emphysema distribution remain la

157 Further assessment of the genetic determinants of ERP is warranted.

158 The molecular genetic determinants of essential tremor are unknown.

159 TeL SNPs capture a substantial proportion of genetic determinants of expression variance and we estim

160 The genetic determinants of fibrinogen in African Americans

161 The specific functional and genetic determinants of follicular lymphoma transformati

162 The genetic determinants of FVII in African Americans (AAs)

163 ysregulated DDR pathways in PDAC to identify genetic determinants of gemcitabine sensitivity, identif

164 dy provided a comprehensive landscape of the genetic determinants of gene expression in different tum

165 s an evolution-guided approach to define the genetic determinants of genome defense and to reveal the

166 The genetic determinants of heart failure (HF) and response

167 wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenu

168 In conclusion, we found that genetic determinants of height appear to increase the ri

169 However, whether genetic determinants of height influence risk is uncerta

170 ere determined and provided insight into the genetic determinants of host and tissue specificity.

171 Genetic determinants of host range adaptation have been

172 burn HTS is known to depend on race, but the genetic determinants of HTS are unknown.

173 We sought to identify genetic determinants of hypoplastic left heart with late

174 The genetic determinants of iMac239's CD4 independence provi

175 These eligible studies have evaluated genetic determinants of immediate reactions (IR) to beta

176 tter understanding of shared and distinctive genetic determinants of immune-mediated inflammatory dis

177 ws the rapid identification of the molecular genetic determinants of important influenza virus charac

178 The genetic determinants of individual clinical cases are in

179 The identification of novel genetic determinants of infant eNO levels might implicat

180 d mice have been instrumental in identifying genetic determinants of inherited blood dyscrasias.

181 The discovery of new genetic determinants of inherited skin disorders has bee

182 el of interferon-stimulated genes as well as genetic determinants of innate immune responses, such as

183 Studying genetic determinants of intermediate phenotypes is a pow

184 accine antigens, we set out to determine the genetic determinants of K. kingae encapsulation.

185 ly-onset COPD would identify additional rare genetic determinants of large effect.

186 Our finding that genetic determinants of long TL increase lung adenocarci

187 Our results suggest that genetic determinants of longitudinal and cross-sectional

188 This study offers a strategy to explore the genetic determinants of longitudinal phenotypes, provide

189 Data are sparse regarding genetic determinants of Lp-PLA(2) mass and activity, and

190 Genetic determinants of macrolide resistance were evalua

191 To understand genetic determinants of mammalian CNS axon regeneration,

192 To identify additional genetic determinants of mercaptopurine toxicity, a genom

193 The genetic determinants of metabolite levels were not assoc

194 Furthermore, understanding of the genetic determinants of metformin response may lead to t

195 We have identified potential genetic determinants of metformin response.

196 , of interest to identify and understand the genetic determinants of methylation and epigenomic varia

197 Genetic determinants of mouse-adapted 2009 H1N1 viral pa

198 We hypothesized that genetic determinants of myeloperoxidase levels influence

199 ta-analysis sought to gain insights into the genetic determinants of myocardial mass.

200 This is the first study addressing the genetic determinants of N uptake and transport in orchid

201 tiple interspecific populations to elucidate genetic determinants of natural variation.

202 ssibility that these genes might function as genetic determinants of normal variation in hair texture

203 Identifying the genetic determinants of ovarian cancer survival and trea

204 thened by a directional consistent effect of genetic determinants of P wave duration.

205 ecombinant progeny for the identification of genetic determinants of parasite traits and adaptations.

206 Genetic determinants of peripheral arterial disease (PAD

207 utagenesis revealed a genome-wide map of the genetic determinants of plant root colonization and offe

208 Thus far, unbiased investigations of the genetic determinants of plasma fetuin-A concentrations h

209 ociation study design, we searched for human genetic determinants of plasma levels of intestinal fatt

210 The goal of this study was to identify genetic determinants of plasma N-terminal proatrial natr

211 The genetic determinants of post-burn hypertrophic scarring

212 Identifying genetic determinants of postnatal eNO levels might aid i

213 his and substantially expand research in the genetic determinants of prostate cancer aggressiveness,

214 We identified dozens of novel genetic determinants of proteins associated with the Fra

215 r, these tools require the identification of genetic determinants of resistance to the full range of

216 ng techniques, novel cardiac biomarkers, and genetic determinants of response to cancer treatment.

217 , mycobacteria, and influenza, together with genetic determinants of response to vaccination.

218 of each of these 156 proteins might identify genetic determinants of risk-associated circulating fact

219 esource to further explore the molecular and genetic determinants of root system architecture.

220 The genetic determinants of rosuvastatin-induced CRP reducti

221 itional association analysis to identify the genetic determinants of salt sensitivity of blood pressu

222 GELnet is able to reveal genetic determinants of sensitivity and resistance for s

223 tumor onset and progression, as well as the genetic determinants of sensitivity or resistance to con

224 This review covers three areas: (a) Genetic determinants of sleep disorders.

225 Genetic determinants of sleep-disordered breathing (SDB)

226 , and no prior data are available addressing genetic determinants of statin-induced changes for this

227 m is the targeted identification of specific genetic determinants of stress adaptation that have evol

228 nonspeech processing has been suggested, the genetic determinants of subcortical speech processing ha

229 The genetic determinants of susceptibility to cutaneous squa

230 Genetic determinants of susceptibility to silver nanopar

231 RNB genera with the aim of identifying novel genetic determinants of symbiotic association and plant

232 We map genetic determinants of testis weight and testis gene ex

233 virus type 1 (HIV-1) infection, but the host genetic determinants of that variability are not well un

234 Our results reveal how genetic determinants of the CTL response control the pro

235 o allow investigation of the genetic and non-genetic determinants of the diseases of middle and old a

236 Genetic determinants of the early steps of carcinogenesi

237 We mapped genetic determinants of the host response using a panel

238 The genetic determinants of the human innate immune response

239 We tested this framework by identifying the genetic determinants of the mesenchymal subtype of gliob

240 ariants may enhance our understanding of the genetic determinants of the metabolome.

241 Nutritional and genetic determinants of the one-carbon metabolism pathwa

242 s of PR interval seem to be mainly driven by genetic determinants of the PR segment.

243 To investigate host genetic determinants of the rate of progression to clini

244 However, the genetic determinants of the renal handling of Mg(2+), wh

245 Little is known about the underlying genetic determinants of thermoregulation in plant-pathog

246 Understanding the molecular and genetic determinants of these metabolic programs is crit

247 urs in distinct pathologic patterns, but the genetic determinants of these patterns are unknown.

248 oviding a basis for new understanding of the genetic determinants of these traits and pulmonary disea

249 aits such as meat quality, information about genetic determinants of these traits is in high demand.

250 host range and virulence and define specific genetic determinants of this function.

251 y, we sought to determine the prevalence and genetic determinants of this phenomenon in a large refer

252 hough recent mapping efforts have elucidated genetic determinants of transcript levels, mapping of pr

253 this model represent the degree to which the genetic determinants of two phenotypes overlap.

254 We evaluated genetic determinants of urine arsenic metabolites in Ame

255 However, the genetic determinants of variable response to aspirin (al

256 This study investigates the genetic and non-genetic determinants of variation in DNA methylation in

257 pression quantitative trait loci (eQTL), the genetic determinants of variation in gene expression pat

258 To investigate the genetic determinants of variation in grip strength, we p

259 71 P. acnes genomes, we identified potential genetic determinants of various P. acnes strains in asso

260 The results suggest that the genetic determinants of viral entry were predominantly e

261 Identification of risk-adjusted genetic determinants of virulence may help to improve pr

262 ily on analyses of specific clones and their genetic determinants of virulence.

263 To identify additional genetic determinants of VWF antigen levels and to minimi

264 bitor treatment, indicating the existence of genetic determinants of Wee1 inhibitor sensitivity other

265 raits are important clinical indicators, the genetic determinants of which have not been fully invest

266 The antibiotic resistance genetic determinants on the LAC-4 genome correlate well

267 Multiple biological, behavioural and genetic determinants or correlates of obesity have been

268 tion to many bat species, suggesting diverse genetic determinants over host range.

269 stress on productive HSV-1 growth and viral genetic determinants potentially enabling replication un

270 upport the hypothesis that currently unknown genetic determinants, potentially discoverable by whole-

271 h heritability in first-degree relatives, AV genetic determinants remain incompletely understood.

272 y and morbidity risk in humans, although its genetic determinants remain largely unknown.

273 s in developmental pathways, the majority of genetic determinants remain unknown.

274 The 64 mutant analyses revealed all the genetic determinants required for assembly of the SPN3US

275 with high-throughput sequencing, to identify genetic determinants required for P. aeruginosa growth u

276 To identify possible viral genetic determinants responsible for differences in symp

277 To identify chromosomal genetic determinants responsible for E. faecalis biofilm

278 The genetic determinants responsible for this canonical case

279 nto the environment of bacterial species and genetic determinants (RIs) involved in antibiotic resist

280 We have now determined an additional genetic determinant(s) for A3F localization to HIV-1 cor

281 Thus, Satb2 is a genetic determinant that mediates proper circuit develop

282 d a genome-wide siRNA screen to evaluate the genetic determinants that confer sensitivity to bortezom

283 ot known whether these strains harbor unique genetic determinants that confer virulence in extra-inte

284 ell-intrinsic response by characterizing the genetic determinants that control the expulsion and deat

285 s, emphasizes the need for identification of genetic determinants that dictate CHIKV virulence in the

286 nary heritage of these viruses, the specific genetic determinants that dictate important phenotypic c

287 The viral genetic determinants that dictate the severity of acute

288 studies have also begun to unravel the host genetic determinants that influence infection outcome.

289 To help us better understand the genetic determinants that lead to differences in the pat

290 In bacteria, recognition typically involves genetic determinants that provide cell surface receptors

291 In this study, we define genetic determinants that regulate reovirus-induced path

292 functions that contribute to virulence, the genetic determinants that regulate the spatial distribut

293 owered flight, but little is known about the genetic determinants that shape their wings.

294 ication of these resistant pathogens and the genetic determinants they possess is needed to assist in

295 tion, leading to derepression of the key ACT genetic determinant Top2b, and provides new insight into

296 he interaction of T. tabaci and TSWV isolate genetic determinants underlie successful transmission of

297 l innate immune evasion strategies and human genetic determinants underlie the transition of acute HC

298 findings establish and characterize a novel genetic determinant underlying sensitivity to diverse ad

299 Although the genetic determinants underlying disease onset remain unc

300 In this study, we have identified genetic determinants underlying the genotype displacemen