ライフサイエンスコーパス: genetic drift

1 ich could be attributed to random mortality (genetic drift).

2 of populations that have experienced recent genetic drift.

3 c regions in migration rates and/or rates of genetic drift.

4 an interaction between natural selection and genetic drift.

5 ue to functional redundancy, asexuality, and genetic drift.

6 der selection for increased evolvability and genetic drift.

7 tochastic lineage birth and death and random genetic drift.

8 enomenon in continuous models without random genetic drift.

9 Eldon-Wakeley model, despite the presence of genetic drift.

10 istent with huge population sizes and minute genetic drift.

11 ng to alternative phenotypes can be fixed by genetic drift.

12 nward to the lower barrier imposed by random genetic drift.

13 t genomic regions rather than by genome-wide genetic drift.

14 tic adaptation, anterior dental loading, and genetic drift.

15 SI+] are only weakly deleterious relative to genetic drift.

16 iple founders for names, non-paternities and genetic drift.

17 eleterious mutational load, and (iii) random genetic drift.

18 se of negative selection rather than neutral genetic drift.

19 e regions than in others-plus the effects of genetic drift.

20 her they were fixed in the population due to genetic drift.

21 y a balance between selection, mutation, and genetic drift.

22 ing fine-mapping resolution, and controlling genetic drift.

23 number were mixed, however, consistent with genetic drift.

24 balance among mutation, weak selection, and genetic drift.

25 populations, thus neglecting the effects of genetic drift.

26 tly exceed previous predictions that ignored genetic drift.

27 ces in the modern human gene pool because of genetic drift.

28 n positive selection or can be due to random genetic drift.

29 creased fixation of deleterious mutations by genetic drift.

30 ty within populations should decrease due to genetic drift.

31 and the low background noise resulting from genetic drift.

32 itochondrial population size, thus affecting genetic drift.

33 leotide substitutions, a hallmark of neutral genetic drift.

34 fragments that accumulate mutations through genetic drift.

35 fitness effect is weaker than the effect of genetic drift.

36 IV-1 genetic variation appeared to be random genetic drift.

37 eeding depression may also be facilitated by genetic drift.

38 cteristically large population sizes and low genetic drift.

39 rd with historical patterns of gene flow and genetic drift.

40 ult in founding populations that can lead to genetic drift.

41 iation patterns compatible with evolution by genetic drift.

42 ional variation, traditionally attributed to genetic drift.

43 erences between the substrains might reflect genetic drift.

44 o diverge through local adaptation or random genetic drift.

45 population structure, natural selection, and genetic drift.

46 a combination of functional constraints and genetic drift.

47 , selection at the level of translation, and genetic drift.

48 was too rapid to be accounted for simply by genetic drift.

49 cantly greater than the null distribution of genetic drift.

50 t can be achieved set by the power of random genetic drift.

51 well as its potential role as a catalyst of genetic drift.

52 cer cells and how PSA expression shifts with genetic drift.

53 a do not fit the pattern expected by neutral genetic drift.

54 al systems is driven by local adaptation and genetic drift.

55 iven by local climatic conditions and random genetic drift.

56 ne tuning but a simple consequence of random genetic drift.

57 d (ii) the efficacy of selection relative to genetic drift.

58 e become fixed within populations because of genetic drift.

59 cies in Sardinians than would be expected by genetic drift.

60 bined activities of mutation, selection, and genetic drift.

61 us has largely been characterized by neutral genetic drift.

62 ukaryotes experiencing high levels of random genetic drift.

63 bution of changes in allele frequency due to genetic drift.

64 of the front shape and amplify the effect of genetic drift.

65 leterious mutations that had become fixed by genetic drift.

66 increasing aphid density and thus weakening genetic drift.

67 as adaptive and non-adaptive forces such as genetic drift.

68 rs them susceptible to mutational erosion by genetic drift.

69 eassignments the sole result of mutation and genetic drift?

70 length beyond which selection dominates over genetic drift; (2) a characteristic angular correlation

71 It is shown that, compared to genetic drift acting alone, migration results in changes

72 estimates for the strengths of selection and genetic drift acting on newly incorporated genetic eleme

73 nucleotide substitution and polymorphism to genetic drift acting on weakly selected mutants, and ass

74 tate invasion, spontaneous cell death due to genetic drift after accumulation of irreversible deleter

75 mately 10(-3)-10(-5) per allele) rather than genetic drift alone (P < 10(-15)).

76 of genetic variation within lineages due to genetic drift alone may explain the observed patterns.

77 of N rose to high frequency in Melanesia by genetic drift alone.

78 not be explained by random recombination and genetic drift alone.

79 eached such high frequency because of random genetic drift alone.

80 eviation at 6p22 was unlikely to result from genetic drift alone.

81 e accounted for by the stochastic effects of genetic drift, although significant clustering does occu

82 tions of allele frequencies above and beyond genetic drift-an effect known as genetic draft.

83 Modeling is done both using a modified genetic drift analytical treatment and computer simulati

84 ial groups are necessarily subject to strong genetic drift and at high risk of inbreeding depression.

85 utionary confounding phenomena (for example, genetic drift and demographic history).

86 pattern over time as a consequence of random genetic drift and discuss potential effects of recombina

87 spontaneously emerged as a result of natural genetic drift and drug treatment.

88 s show that reduced genetic variation due to genetic drift and founder effects limits the ability of

89 eat all loci as equally subject to forces of genetic drift and gene flow.

90 species' ranges due to spatial variation in genetic drift and gene flow.

91 against many H1 strains that have undergone genetic drift and has potential as a "subtype universal"

92 ld prevent differentiation of populations by genetic drift and hinder local adaptation.

93 l breeding, because it measures the rates of genetic drift and inbreeding and affects the efficacy of

94 the transition from a stable quasispecies to genetic drift and loss of information can also occur by

95 opulation size is sufficiently small, random genetic drift and mutation can conspire to produce chang

96 tive power of two nonadaptive forces: random genetic drift and mutation pressure.

97 rent amplifications of the effects of random genetic drift and mutation.

98 n without invoking the nonadaptive forces of genetic drift and mutation.

99 Competition between random genetic drift and natural selection play a central role

100 Because evolutionary processes such as genetic drift and natural selection play a crucial role

101 ation generates the heritable variation that genetic drift and natural selection shape.

102 be acted upon by the twin engines of random genetic drift and natural selection.

103 f a stochastic evolutionary model simulating genetic drift and neoplastic progression.

104 f symbionts, which experience high levels of genetic drift and potential selection for selfish traits

105 N can accelerate extinction by strengthening genetic drift and relaxing selection.

106 olecules, namely, structural decay spread by genetic drift and repair spread by selection.

107 aper summarizes simulation studies of random genetic drift and selection in malaria parasites that ta

108 erate the process of evolution beyond simple genetic drift and selection, helping to rapidly generate

109 g of its aphid host, it is hypothesized that genetic drift and the accumulation of slightly deleterio

110 (rate heterogeneity), selection, and random genetic drift and the limitations of phylogenetic approa

111 in evolutionary biology because it controls genetic drift and the response to selection.

112 However, a simple model incorporating random genetic drift and weak mutation pressure against intron-

113 esult from resampling of finite populations (genetic drift) and the random genetic background of near

114 ms, such as mutation, natural selection, and genetic drift, and also the interactions between genetic

115 by selection for efficient ribosomal usage, genetic drift, and biased mutation.

116 orces of mutation, recombination, and random genetic drift, and drawing from observations on the join

117 of natural selection, population migration, genetic drift, and founder effects have shaped the world

118 determines the amount of genetic variation, genetic drift, and linkage disequilibrium (LD) in popula

119 c factors such as historic population sizes, genetic drift, and mutation can have pronounced effects

120 Although mutation, genetic drift, and natural selection are well establishe

121 has spread to, and in turn on how migration, genetic drift, and natural selection have acted.

122 lies a complex interaction between mutation, genetic drift, and positive selection during duplicate f

123 natural selection, population growth, random genetic drift, and recombination in shaping the variatio

124 erge through a combination of recombination, genetic drift, and selection driven by population immuni

125 Through evolution, genetic drift, and speciation, photosynthetic organisms

126 o estimate the contribution of selection and genetic drift, and their interplay, to the evolution of

127 consequent reduction in the power of random genetic drift appears to be sufficient to enable natural

128 , gene conversion, recombination, and random genetic drift, approximate formulas for the expectations

129 its incorporation of a cumulative effect of genetic drift as humans colonized the world.

130 ect changes in phenotype frequency caused by genetic drift, as well as a simplified simulation of sex

131 global pattern reflects the accumulation of genetic drift associated with a recent African origin of

132 rifying selection, reversible mutations, and genetic drift, assuming a stationary population size.

133 tualistic partners to stay together, because genetic drift at the expansion front creates regions of

134 dation of the rate of loss of variability by genetic drift at this locus.

135 rms of population genetics processes such as genetic drift, balancing and purifying selection, and th

136 side as chronic infection is established and genetic drift becomes the dominant evolutionary force.

137 ibe the genetic relationships and pattern of genetic drift between extant domesticated strains and wi

138 in the balance between natural selection and genetic drift between two related lineages.

139 fection, ongoing HCV evolution is not random genetic drift but rather the product of strong pressure

140 ines the opportunity for local selection and genetic drift, but has been well studied in few animal-p

141 gion-specific sexual selection and/or random genetic drift, but not universal sexual selection.

142 ve genomic DNA losses and increased power of genetic drift, but we also suggest that additional evide

143 alytical tools and simulations, we show that genetic drift can generate a sharp margin to a species'

144 Here, it is argued that random genetic drift can impose a strong barrier to the advance

145 These results demonstrate that genetic drift can lead to the evolution of complexity in

146 h small population sizes, where the power of genetic drift can outweigh that of selection.

147 nd Daghestani populations is consistent with genetic drift caused by patrilocal endogamy.

148 ay have developed during intervals of strong genetic drift caused by periodic blooms of a subset of g

149 ations provide compelling support for random genetic drift (chance founder effects, one approximately

150 nce, a phenomenon we call 'geometry-enhanced genetic drift', complementary to the founder effect asso

151 utations in the human genome, suggested that genetic drift could play a role in population dynamics o

152 ment of spatial structure and enhancement of genetic drift, could complement molecular strategies in

153 understood with influenza viruses, in which genetic drift creates antigenically distinct strains tha

154 less experience radically different forms of genetic drift, depending on the reproductive mechanism,

155 he present, most likely fortuitously through genetic drift despite its systematic elimination by bias

156 When a duplicate locus has recently fixed by genetic drift, diversity in the new gene is expected to

157 o what extent selection, rather than neutral genetic drift, drives the fixation and early evolution o

158 lyses is needed to support a primary role of genetic drift driving ancient genome reduction of marine

159 y distance, the divergence of populations by genetic drift due to limited dispersal, is responsible.

160 Although genetic drift due to spatial isolation and bottlenecks s

161 the amount of lost variation is explained by genetic drift during the bottleneck and by natural selec

162 obability of a single mutation fixing due to genetic drift during the recovery experiment, we observe

163 mutualistic range expansions as a result of genetic drift effects preceding local resource depletion

164 ak or asymmetric mutualism is overwhelmed by genetic drift even when mutualism is still beneficial, s

165 ng that gene frequencies change at random by genetic drift, even in the absence of natural selection,

166 m the joint processes of mutation and random genetic drift, even in the face of constant directional

167 vely neutral, highlighting the importance of genetic drift-even for enhancers underlying conserved ph

168 ion, subsequently shaped by selection and/or genetic drift, followed by a more recent exotic European

169 ty of these diseases is likely the result of genetic drift following a bottleneck.

170 s, adapted from the work of Kimura on random genetic drift, for the full mtDNA heteroplasmy distribut

171 The solution could lie in distinguishing genetic drift from 'genetic draft' and in dissecting the

172 city was found to have likely arisen through genetic drift from the ancestral cP.

173 In finite populations, genetic drift generates interference between selected lo

174 In finite populations subject to selection, genetic drift generates negative linkage disequilibrium,

175 tation, and at the population level, such as genetic drift, give rise to neutral patterns that we can

176 lation size decreases, selection weakens and genetic drift grows in importance.

177 ions declined significantly, suggesting that genetic drift has increased because of a population bott

178 * Our results suggest that genetic drift has played a significant role in the recen

179 and multiple founder events and/or long-term genetic drift have been of greater consequence for neutr

180 on is expected to proliferate as a result of genetic drift in a finite population undergoing selectio

181 ments evolve independently of one another by genetic drift in a host-specific fashion, generating qua

182 The impact of genetic drift in a population is largely determined by i

183 ese founder events are the spatial analog of genetic drift in a randomly mating population.

184 ilizes the differences accumulated by random genetic drift in allele count data from single-nucleotid

185 age disequilibrium and substantial levels of genetic drift in comparison with their wild-born counter

186 tions, they do not rule out a major role for genetic drift in driving ancient ecological switches.

187 e hybridization and sampling events, and the genetic drift in each ancestral population within the in

188 YSV genotypes further emphasizes the role of genetic drift in modeling the population architecture, e

189 s inferred from European GWASs are biased by genetic drift in other populations even when choosing th

190 gional scale seems too limited to counteract genetic drift in patchily distributed tropical plants.

191 loci were also found, suggesting a role for genetic drift in shaping adaptive variation.

192 cular clock and emphasized the importance of genetic drift in shaping molecular evolution.

193 post-glacial colonization or to contemporary genetic drift in small, peripheral populations.

194 ast, heterogeneity appears to be a result of genetic drift in the absence of the restriction of tick

195 Taken together, these results suggest that genetic drift in the B10.BR strain has significantly imp

196 tleneck, indicating an important role of the genetic drift in the evolution of the virus.

197 ow from an analysis of natural selection and genetic drift in the island model of subdivision in the

198 Our results show that random genetic drift in the malaria life cycle is more pronounc

199 ty is a non-adaptive property resulting from genetic drift in which constructive neutral evolution pr

200 ole of natural selection, relative to random genetic drift, in governing this process is unclear.

201 tructure is influenced by factors other than genetic drift, including both selection and differential

202 in population-genetic settings where random genetic drift is a relatively strong force.

203 nt to which variation in the power of random genetic drift is capable of influencing phylogenetic div

204 erior dental loading are well supported, but genetic drift is consistent with the available evidence.

205 utral divergence resulting from mutation and genetic drift is critical for understanding the evolutio

206 * In small isolated populations, genetic drift is expected to increase chance fixation of

207 rests on a 'standard model' in which random genetic drift is the dominant force, selective sweeps oc

208 lection (i.e., its tendency to dominate over genetic drift) is extremely weak relative to classical m

209 in surface-associated growth because strong genetic drift leads to spatial isolation of donor and re

210 We show by simulation that genetic drift, leptokurtosis of mutational effects, and

211 on with varying strength among sites, random genetic drift, linkage, and recombination.

212 er (F(ST) > 0.4) indicating the influence of genetic drift, long isolation (possibly dating from the

213 Recent research has shown that genetic drift may have produced many cranial differences

214 s of selection and that population size (and genetic drift) may be an important determinant of the ev

215 usly published results, which suggested that genetic drift might have occurred within the B10.BR stra

216 e geographically restricted due to mutation, genetic drift, migration and natural selection, knowledg

217 pproach we fitted predictions from models of genetic drift, migration, constant selection, heterozygo

218 imary role of neutral evolutionary processes-genetic drift, mutation, and gene flow structured by pop

219 oevolutionary processes, including mutation, genetic drift, natural selection and gene flow, can prov

220 tibility alleles in the Ashkenazim is due to genetic drift, not selection.

221 Such a resistance contributes to the genetic drift of evolving tumors as well as to their lim

222 prove to be a useful tool for monitoring the genetic drift of human immunodeficiency virus and SIV in

223 Genetic drift of influenza virus genomic sequences occur

224 nistic pleiotropy) and selection-independent genetic drift of neutral (or nearly neutral) mutations (

225 emnants is often assumed to be simply due to genetic drift of neutral mutations that occurred after t

226 can be explained by a predominance of random genetic drift of neutral mutations with brief episodes o

227 patterns in mortality were compared with the genetic drift of the influenza viruses by analyzing hema

228 red to evaluate the effects of selection and genetic drift on phenotypic differentiation.

229 Here we measure the effect of genetic drift on the shape of the G matrix using a large

230 axed selection mainly due to higher rates of genetic drift on the wave front.

231 due to abandonment of unproductive lineages, genetic drift, on-going natural selection, and recent br

232 ected if evolution is driven by mutation and genetic drift only, with an excess of low-frequency poly

233 To minimize false discovery due to genetic drift, only 42 of the candidate selection region

234 er the observed variability is due to random genetic drift or is a result of natural selection.

235 l ancestry associated with migration, random genetic drift or natural selection.

236 ex chromosomes can be classified in terms of genetic drift or positive selection being the primary me

237 ferentially purged from, or are retained by, genetic drift or positive selection in mammalian genomes

238 o be explained by any simple model of random genetic drift or sampling variation.

239 I1307K, has sparked controversy over whether genetic drift or selection is the underlying cause.

240 g Europeans, either because of extraordinary genetic drift or selective sweeps.

241 e of small effect-are lost due either to (1) genetic drift or to (2) competition among clones carryin

242 rope, consistent with discordant and extreme genetic drifts or adaptive selections after human migrat

243 sland populations, geographic isolation with genetic drift, or a combination of these factors.

244 istance dispersal founding event followed by genetic drift; or the response in an obligate mycorrhiza

245 lations experienced greater evolution due to genetic drift over the season.

246 rk has shown that hotspots can evolve due to genetic drift overpowering their intrinsic disadvantage.

247 However, genetic drift, particularly due to founder effects, will

248 lated populations lose genetic diversity via genetic drift, phonemes are not subject to drift in the

249 broadly consistent with the hypothesis that genetic drift plays a role in shaping genomic mutation r

250 d how asexual reproduction may interact with genetic drift (population size).

251 is believed to be caused by a combination of genetic drift, population immunity, and recombination, b

252 ulation-specific phenomena such as mutation, genetic drift, population structure, and variations in a

253 y understood, and the relative importance of genetic drift, positive selection, and relaxed purifying

254 Second, effective population size and genetic drift profoundly affect the statistical frequenc

255 * Genetic drift promotes fixation of deleterious mutations

256 to a lower limit set by the power of random genetic drift rather than by intrinsic physiological lim

257 munity genes are neutral mutation and random genetic drift rather than diversifying selection, which

258 It extends the population dynamics of genetic drift, recasting Kimura's selectively neutral th

259 Thus, random genetic drift, recent changes in mutational tendencies,

260 maintained by mutation-selection balance and genetic drift, recent evidence indicates that intra-locu

261 , likely promoting ecological divergence and genetic drift resulting in a wide range of genome-wide d

262 an implanted xenograft, reverse the initial genetic drift seen after passage on non-humanized mice a

263 y forces of mutation, natural selection, and genetic drift shape the pattern of phenotypic variation

264 Population genetics theory predicts that genetic drift should eliminate shared polymorphism, lead

265 pproximately balanced by the power of random genetic drift, such that variation in equilibrium genome

266 f Africa, chromosome X experienced much more genetic drift than is expected from the pattern on the a

267 tracking, at the sub-strain level, the rapid genetic drift that M. avium isolates undergo in nature a

268 d method also yields reasonable estimates of genetic drift that occurred to each population, which tr

269 imate jointly the admixture proportions, the genetic drift that occurred to the admixed population an

270 Withstanding 3.5 billion years of genetic drift, the canonical genetic code remains such a

271 lutionary patterns and processes governed by genetic drift, the small effects of such mutations make

272 However, the potential for genetic drift to generate conditions that produce this o

273 In Bacteria, assessing the contribution of genetic drift to genome evolution is problematic because

274 Our genetic drift treatment takes into account that after ge

275 the paradoxical constructive role of random genetic drift, typically mildly deleterious, in fosterin

276 We use Brownian motion to model genetic drift under neutrality, and a deterministic mode

277 We tested a stochastic model of genetic drift using partial envelope sequences sampled l

278 ed by determining the relative importance of genetic drift vs. positive selection in the fixation of

279 es found in the kidney and the rate at which genetic drift was affecting the disseminated populations

280 Little genetic drift was detected in viruses shed by the same s

281 te-occupancy frequency data it appeared that genetic drift was the major force acting on these IS630/

282 explore the antagonism between mutualism and genetic drift, we grew cross-feeding strains of the budd

283 low levels of immigration and high levels of genetic drift, whereas those populations less isolated d

284 eased variance enhances levels of short-term genetic drift which is predicted to inhibit adaptation.

285 Two forces affecting genetic variation are genetic drift (which decreases genetic variation within

286 Genetic drift, which is particularly effective within sm

287 agonistic selection, recurrent mutation, and genetic drift, which should collectively shape empirical

288 own to sensitively depend on the strength of genetic drift, which varies among strains and environmen

289 a but that both also experienced more recent genetic drift, which was greater in East Asians.

290 However, genetic drift will have a greater influence on small iso

291 Thus, a history of genetic drift with accumulation of point mutations was n

292 volved populations due to both selection and genetic drift with expectations under drift only.

293 successful samples to forward simulations of genetic drift with natural selection and find that selec

294 rguing against positive selection and toward genetic drift with relaxation of purifying selection.

295 uropean farmers showed that the Kalash share genetic drift with the Paleolithic Siberian hunter-gathe

296 n augmenting genetic differentiation through genetic drift, with isolated northern European breeds sh

297 tain mobility and persistence in the face of genetic drift within potential host target sites.

298 genotype level, there was relatively little genetic drift within the individual gene segments, sugge

299 to reveal possible genomic heterogeneity and genetic drifts within cell lines.

300 ose produced by stochastic processes (random genetic drift) within a species, and clades that represe