ライフサイエンスコーパス: genetic element

1 e inheritance of yeast prions (protein-based genetic elements).

2 a unique combination of pathogen and selfish genetic element.

3 ment and instead is a component of a selfish genetic element.

4 and determined their association with mobile genetic elements.

5 wide spectrum of viruses and other parasitic genetic elements.

6 erived from bacteriophages and other foreign genetic elements.

7 rsity, accumulation of mutations, and mobile genetic elements.

8 r memory of previous encounters with foreign genetic elements.

9 ovides RNA-mediated protection from invading genetic elements.

10 reness for the global dissemination of these genetic elements.

11 abroad for the dissemination of these mobile genetic elements.

12 r the discovery and functional annotation of genetic elements.

13 man genome that has been colonized by mobile genetic elements.

14 otect germ cells from the activity of mobile genetic elements.

15 n and are present on phages and other mobile genetic elements.

16 e of autonomously replicating foreign mobile genetic elements.

17 protect bacteria and archaea against foreign genetic elements.

18 as an adaptive immune system against foreign genetic elements.

19 genome stability and defence against foreign genetic elements.

20 rabilities that are capitalized on by mobile genetic elements.

21 protection against viruses and other mobile genetic elements.

22 romycetales, indicating that byps are mobile genetic elements.

23 e immunity against phages and other invading genetic elements.

24 nd by the high-order spatial organization of genetic elements.

25 , where they act as heritable, protein-based genetic elements.

26 rokaryotic defense mechanism against foreign genetic elements.

27 eletions to allow investigation of genes and genetic elements.

28 ing technology for studying the functions of genetic elements.

29 defends the germline genome against selfish genetic elements.

30 is a prokaryotic host defense system against genetic elements.

31 ge fraction of our genome consists of mobile genetic elements.

32 d by the ad hoc reuse of many types of basic genetic elements.

33 framework for quantifying the performance of genetic elements.

34 d archaea, and are often specified by mobile genetic elements.

35 systems protect prokaryotes against foreign genetic elements.

36 ptive immune system against extrachromosomal genetic elements.

37 ted in between the synthetically interacting genetic elements.

38 n shown to contain multiple different mobile genetic elements.

39 vectors; third, parallel origin from related genetic elements.

40 richia coli, its phages, plasmids and mobile genetic elements.

41 -cell genomes against the activity of mobile genetic elements.

42 that appear to have been derived from mobile genetic elements.

43 idered to be exceptionally successful mobile genetic elements.

44 ogenous retroviruses as well as other mobile genetic elements.

45 ARGs and their co-occurrence with associated genetic elements.

46 lysis of the 16S rRNA gene and various other genetic elements.

47 olerant DNA endonucleases that act as mobile genetic elements.

48 stem that protects prokaryotes from invading genetic elements.

49 by bacteria and archaea to fend off foreign genetic elements.

50 ae and suggest that they spread as parasitic genetic elements.

51 although SCCmec has been designated a mobile genetic element, a mechanism for its transfer has not be

52 as well as widespread circulation of mobile genetic elements across the bacterial population.

53 mic conflict describes a phenomenon in which genetic elements act 'selfishly' to gain a transmission

54 e transcriptional network within which these genetic elements act to orchestrate hypertrophy gene exp

55 This genetic element allows for predictable tuning, insulatio

56 a general approach for creating context-free genetic elements and can be readily used in the bottom-u

57 ative traits are often propagated via mobile genetic elements and can be virulence factors from a bio

58 elements of VirB8-like proteins from mobile genetic elements and chromosomally encoded T4SS from G+

59 genes involved in DNA metabolism, in mobile genetic elements and defective prophages.

60 nds; evolutionary connections between mobile genetic elements and defense, whereby genes of mobile el

61 In addition to LuxR-LuxI, numerous other genetic elements and environmental conditions control bi

62 They were flanked by multiple mobile genetic elements and highly conserved among IPU-minerali

63 isruptions that enhance silencing of foreign genetic elements and identified 69 genes.

64 h degree of convergence influenced by mobile genetic elements and niche adaptation.

65 y-associated pandemics represented by mobile genetic elements and nonsynonymous mutations affecting a

66 s mediated by a diverse complement of mobile genetic elements and occurs primarily by conjugation or

67 Several recently found genetic elements and resistance determinants for quinolo

68 t harmonious interactions between co-evolved genetic elements and result in reduced male fertility, s

69 rokaryotes against bacteriophages and mobile genetic elements and serve as the basis for revolutionar

70 To define V3 genetic elements and structural features underlying diff

71 e effect of the serial deletion of 5' and 3' genetic elements and sublethal doses of histone deacetyl

72 n, we isolated a set of NF-kappaB-activating genetic elements and tested their oncogenic potential in

73 rnal evolutionary arms races between selfish genetic elements and the genes of the host genome.

74 Simple tandem repeats are highly variable genetic elements and widespread in genomes of many organ

75 d valuable data from microsatellites, mobile genetic elements, and accurate divergence time estimates

76 to the lytic origin of replication (OriLyt) genetic elements, and BET inhibitors prevent viral late

77 Retrotransposons are mobile genetic elements, and their mobility can lead to genomic

78 ction and subsequent degradation of invading genetic elements, and they have been classified into thr

79 rous; beta-lactamase genes carried on mobile genetic elements are a key mechanism for the rapid sprea

80 sting that the functional profiles of mobile genetic elements are associated with their environment,

81 As the genomes and the sequences for genetic elements are further refined, this tool will bec

82 es, but some homologs associated with mobile genetic elements are larger and contain an extra C-termi

83 Mobile genetic elements are ubiquitous.

84 However, the causative genetic elements are unknown.

85 e course of evolution, genomes acquire novel genetic elements as sources of functional and phenotypic

86 ermed YeastFab Assembly) to synthesize these genetic elements as standardized biological parts, which

87 and functional characterization of specific genetic elements associated with a phenotype of interest

88 inland China revealed the presence of mobile genetic elements associated with the expansion of emm12

89 gene transfer permits rapid dissemination of genetic elements between individuals in bacterial popula

90 istance due to horizontal transfer of mobile genetic elements between species.

91 iruses might descend from primordial selfish genetic elements, bona fide viruses evolved on multiple,

92 Cells benefit from silencing foreign genetic elements but must simultaneously avoid inactivat

93 ed (Cas) systems detect and degrade invasive genetic elements by an RNA-guided, RNA-targeting multisu

94 RNAs (crRNAs) that protect against invasive genetic elements by antisense targeting.

95 Physical separation of linked genetic elements by CRISPR-mediated cleavage is an effec

96 ia and archaea acquire resistance to foreign genetic elements by integrating fragments of foreign DNA

97 hes, we have designed and introduced a novel genetic element called a ribo-attenuator in Bacteria.

98 As that provide defense against transposable genetic elements called transposons.

99 Importantly, our data show that mobile genetic elements can persist within the bacterial popula

100 on a single-celled ciliate reveal how mobile genetic elements can shape a genome, even one which is n

101 Plasmids are self-replicating genetic elements capable of mobilization between differe

102 Inteins are mobile genetic elements capable of self-splicing post-translati

103 fit the guns-for-hire concept whereby mobile genetic elements capture host defense systems and repurp

104 Finally, we constructed a synthetic mobile genetic element carrying both the degradation pathway an

105 driven by horizontal dissemination of mobile genetic elements carrying blaKPC-2, followed by the intr

106 f pollutants, which can co-select for mobile genetic elements carrying multiple resistant genes.

107 tional multinational clinical trials for the genetic elements carrying pvl and 30 other virulence gen

108 Genetic elements compete for transmission through meiosi

109 The genetic elements composing HCAbs have been identified, b

110 LINE-1 (L1) retrotransposons are mobile genetic elements comprising ~17% of the human genome.

111 These mobile genetic elements confer expression of superantigens SSA

112 Here we demonstrate that a synthetic genetic element, consisting of mosquito regulatory regio

113 m mutations or more importantly, from mobile genetic elements containing multiple resistance determin

114 l-spatial structure with diversity in mobile genetic element content, features that are useful for id

115 ates, are characterized by a distinct set of genetic elements controlling their gene expression.

116 oped an expression cassette architecture for genetic elements controlling transcription and translati

117 lso demonstrate that self-propagating active genetic elements (CopyCat elements) can efficiently dele

118 ease genes (HEGs), a class of simple selfish genetic elements, could be exploited for this purpose.

119 We expect the genetic element definitions validated here can be collec

120 ngly influenced by the acquisition of mobile genetic elements encoding determinants involved in niche

121 of genomic DNA that contains all cis-acting genetic elements essential for accurate physiologic expr

122 es, and mobile elements, while these foreign genetic elements evolve diverse anti-CRISPR proteins to

123 mber variation of Sly and Rbmy with the ChrY genetic element exerting regulatory properties.

124 Although several types of selfish genetic elements exist in nature, few have been successf

125 n axolotls to permanently express markers or genetic elements for functional study.

126 ation of high-order barcoded combinations of genetic elements for high-throughput multiplexed charact

127 g strategy that generates fully exchangeable genetic elements for multigene engineering, the GB2.0 to

128 conjugative elements (ICEs) are self-mobile genetic elements found in the genomes of some bacteria.

129 Genetic elements found on the assembled genomic fragment

130 n for the horizontal transfer of a "selfish" genetic element from cell to cell via membrane fusion.

131 was significantly improved by incorporating genetic elements from mammalian viruses.

132 is the limited number of well-characterized genetic elements from which to build.

133 by an inadequate understanding of molecular genetic elements governing tumor progression.

134 of Ewing sarcoma in human cells with defined genetic elements has been challenging.

135 Horizontal transfer of mobile genetic elements has played a central role in the evolut

136 Many of these genetic elements have been found to encode factors criti

137 called generalized transduction, some mobile genetic elements have developed elegant and sophisticate

138 , recombinases derived from unrelated mobile genetic elements have essential roles in both prokaryoti

139 Mobile genetic elements have the ability to move between positi

140 Transposable elements (TEs) are mobile genetic elements, highly enriched in heterochromatin, th

141 The mobile genetic element ICEBs1 is an integrative and conjugative

142 ibit the replication of HIV and other mobile genetic elements.IMPORTANCE Piwil proteins inhibit the m

143 S albumin promoter is a promising endogenous genetic element in genetic engineering approaches requir

144 ame and can also be useful as a heterologous genetic element in other important oil seed crop plants

145 changes in BP, indicating that at least one genetic element in this refined region directly affects

146 ity of the mobilome (the total of all mobile genetic elements in a genome) between aquatic and terres

147 , suggesting a tumor-suppressor function for genetic elements in addition to DLEU2/miR-15a/16-1.

148 rsity of DNA sequences and multiple types of genetic elements in and near centromeres support centrom

149 s have overlapping roles in silencing mobile genetic elements in animals.

150 nalogous manner to plasmids and other mobile genetic elements in bacteria.

151 s' highlights potential relevance of selfish genetic elements in facilitating lateral gene transfer i

152 ptive and heritable immunity against foreign genetic elements in most archaea and many bacteria.

153 based adaptive immune system against foreign genetic elements in prokaryotes.

154 izes the custom annotation tracks for mobile genetic elements in public genome browsers.

155 iwil proteins inhibit the movement of mobile genetic elements in the germ line.

156 proteins restrict the replication of mobile genetic elements in the germ line.

157 rd genetic screen to systematically identify genetic elements in the HIV LTR promoter that modulate t

158 ht on the roles of these recently identified genetic elements in the mechanisms of host resistance an

159 e unique, often due to differences in mobile genetic elements in the plasmids.

160 ing frames (uORFs) are ubiquitous repressive genetic elements in vertebrate mRNAs.

161 d genetic drift acting on newly incorporated genetic elements in viral genomes, under conditions of e

162 including McClintock's archetypal Ac mobile genetic element, in many eukaryotic species.

163 of the evolutionary strategy of these mobile genetic elements, in addition to their carriage of impor

164 els of abundance of ARGs and those of mobile genetic elements (including integrons and plasmids), whi

165 nce are carried by plasmids and other mobile genetic elements, including bacteriophages and their rel

166 ons between genome structural variations and genetic elements, including chromosomal rearrangements,

167 form enables massively parallel detection of genetic elements, including gene transcripts and molecul

168 since its introduction by exchanging mobile genetic elements, including integrative conjugative elem

169 itochondria and other maternally transmitted genetic elements, including the role of cytonuclear inco

170 volutionarily connected to capsidless mobile genetic elements, including various plasmids and transpo

171 conjugative transposons) are modular mobile genetic elements integrated into a host genome and are p

172 construction is to manipulate viral proteins/genetic elements involved in antagonizing the host immun

173 n order to identify additional veA-dependent genetic elements involved in regulating ST production, w

174 ly within various host epithelial cells, the genetic elements involved in the HPT system in S. aureus

175 , widespread prion whose activity as selfish genetic element is counteracted by balancing selection f

176 Through interaction with genetic elements, KChIP2 transcriptionally repressed the

177 In yeast, the cellular extrachromosomal genetic element [KIL-d] alters killer activity of M doub

178 us reservoirs in animals have provided novel genetic elements leading to the emergence of global pand

179 teraction of the host genes with surrounding genetic elements, like a convergently overlapped gene an

180 We conclude that these conserved functional genetic elements likely facilitated the repeated evoluti

181 titative behaviors for novel combinations of genetic elements limits the rational engineering of biol

182 ion and further show the lineage ontogeny of genetic elements linked to diverse human diseases.

183 t support WBT and two did not support mobile genetic element-mediated transmission.

184 Conjugative plasmids are the principal genetic elements mediating the horizontal transfer of ge

185 ; and substantial bla KPC-associated, mobile genetic element (MGE) diversity (50% not within complete

186 erent functional classes of genes and mobile genetic elements (MGE).

187 ndergoing HDT through transmission of mobile genetic elements (MGEs) and genetic transformation.

188 e assembled genomic fragments include mobile genetic elements (MGEs) and metal resistance genes (MRGs

189 Fitness costs associated with mobile genetic elements (MGEs) are thought to constrain HGT, bu

190 in resistance and virulence genes on mobile genetic elements (MGEs) between 40 isolates of methicill

191 structure of Escherichia coli and of mobile genetic elements (MGEs) carrying the mcr-1 gene.

192 ntibiotic-resistance genes (ARGs) and mobile genetic elements (MGEs) in farm environments can potenti

193 eptococcus thermophilus revealed that mobile genetic elements (MGEs) likely contributed to gene acqui

194 gulating the expression of genes from mobile genetic elements (MGEs), LexA often does so in concert w

195 an spread horizontally by residing on mobile genetic elements (MGEs).

196 ls differ in the presence of specific mobile genetic elements (MGEs).

197 recombination in regions adjacent to mobile genetic elements (MGEs).

198 s, protecting cells from infection by mobile genetic elements (MGEs).

199 lline cellulose efficiently and contains the genetic elements necessary for cellulosome production.

200 reatic cancer), a homing cassette, and other genetic elements needed for rapid insertion and conditio

201 Minimal bacterial gene set comprises the genetic elements needed for survival of engineered bacte

202 yploidy supports the acquisition of unstable genetic elements normally not seen in essential genes.

203 s do not interact directly but both occupy a genetic element of Gbx2, which is required for aortic ar

204 ilize AAV pseudotype vectors, containing the genetic elements of the canonical AAV2, packaged within

205 date mechanism through which the interacting genetic elements of the resistant Mcs5a allele modulate

206 tains the most abundant and fastest mutating genetic elements on Earth.

207 arity between epigenetic factors, or between genetic elements on the basis of their epigenetic state,

208 lowed regulatory modulation through inserted genetic elements, on-demand control of the expression/tr

209 d study the epigenetic state of any class of genetic element or genomic region, we focus on two speci

210 ising resilience of this gene to addition of genetic elements or helix substitutions with phylogeneti

211 oorganisms, and assist in identifying mobile genetic elements or lateral gene transfer events.

212 particular nucleotides or amino acids in the genetic elements or proteins, and is widely used in in v

213 he resulting fusions-supplied exogenously as genetic elements or purified protein fragments-had no si

214 jejuni ST-21 and ST-45 complexes identified genetic elements over-represented in clinical isolates t

215 Our analysis also identified genetic elements, particularly HLA, as key drivers of au

216 A different composition of mobile genetic elements (plasmids and phages) or amino acid sub

217 e 5' chromosomal junction of a 45-kbp mobile genetic element, pLP45, which can exist as an episome or

218 gative elements (ICEs) are ubiquitous mobile genetic elements present as "genomic islands" within bac

219 n single nucleotide polymorphisms and mobile genetic element profiles, suggesting a single L. pneumop

220 CRISPR-Cas immunity against invasive mobile genetic elements, prokaryotes must first integrate fragm

221 r area of investigation is the assessment of genetic elements regulating tumor cell proliferation, es

222 odified DNA donor molecule acts as a selfish genetic element, replaces the targeted site and propagat

223 To test for cis genetic elements required for Pxr function, we deleted t

224 opagation of bacteriophages and other mobile genetic elements requires exploitation of the phage mech

225 Analysing our data with exons as 'immobile genetic elements' revealed a similar frequency of unexpe

226 nown virulence factors, while several mobile genetic elements (SaPI5 and prophage SA3usa) were strong

227 gene, which is carried on a distinct mobile genetic element (SCCmec), the expression of which is con

228 resistance genes via the transfer of mobile genetic elements, selective pressure in vivo resulting i

229 defense and antibiotic selection for mobile genetic elements shapes in vitro E. faecalis populations

230 of the Dissociation locus, the first mobile genetic element she identified.

231 mode of germ-line transmission by a selfish genetic element signifies a mechanistic variation within

232 eritance phenomenon in which certain selfish genetic elements skew sexual transmission in their own f

233 Selfish genetic elements spread in natural populations and have

234 lution to regulate genomic loci and to study genetic elements such as enhancers in biological process

235 Mobile genetic elements such as genomic islands (GIs) have been

236 antibiotic-resistant genes located on mobile genetic elements such as genomic islands, prophages, pat

237 cterial genome rearrangements involve mobile genetic elements such as insertion sequence (IS) element

238 t protects the prokaryotes against exogenous genetic elements such as phages.

239 curs through the uptake of DNA from invasive genetic elements such as plasmids and viruses, followed

240 n environment and the contribution of mobile genetic elements such as plasmids.

241 e sequence-specific immunity against selfish genetic elements such as viruses and plasmids, by specif

242 ed parallels in other maternally transmitted genetic elements, such as bacterial endosymbionts of art

243 mmune systems that protect them from foreign genetic elements, such as invading viruses.

244 (CRISPRs) to protect themselves from foreign genetic elements, such as phage and plasmids.

245 ve immune system that interferes with mobile genetic elements, such as plasmids and phages.

246 esistance and enable stabilization of mobile genetic elements, such as plasmids.

247 the pore-forming subunit, define the minimal genetic elements sufficient for metazoan and nonmetazoan

248 e domains that demarcate active and inactive genetic elements, suggesting that compartmentalization i

249 VRC01-class antibodies require few specific genetic elements, suggesting that naive-B cells with VRC

250 Yeasts contain various protein-based genetic elements, termed prions, that result from the st

251 In addition, we found that the genetic element that binds both Tbx1 and p53 is highly e

252 Transposons are mobile genetic elements that are found in nearly all organisms,

253 cus aureus pathogenicity islands (SaPIs) are genetic elements that are mobilized by specific helper p

254 Inteins are mobile genetic elements that are spliced out of proteins after

255 b/Trithorax response elements (PRE/TREs) are genetic elements that can stably silence or activate gen

256 ntrol regions (ICRs), which are the discrete genetic elements that confer imprinted monoallelic expre

257 pread family of chromosomally located mobile genetic elements that contribute substantially to intra-

258 slands (PICIs) are a family of highly mobile genetic elements that contribute substantively to horizo

259 In this issue of Blood, Li et al reveal the genetic elements that control the activity of Bcl11b, a

260 lands are integrative and conjugative mobile genetic elements that convert nonsymbiotic rhizobia into

261 However, the genetic elements that define the expression of Otx2 duri

262 regulated by multiple positive and negative genetic elements that direct expression of genes require

263 Transposons are ubiquitous genetic elements that drive genome rearrangements, evolu

264 Inteins are parasitic genetic elements that excise themselves at the protein l

265 This system is also targeted by mobile genetic elements that integrate into chromosomal dif sit

266 at strain consists of two non-protein-coding genetic elements that must be located on the same chromo

267 ort tandem repeats (STRs) are highly mutable genetic elements that often reside in regulatory and cod

268 Genetic elements that replicate extrachromosomally are r

269 mids are stably maintained extra-chromosomal genetic elements that replicate independently from the h

270 Inteins are invasive genetic elements that self-splice at the protein level f

271 Inteins are mobile genetic elements that self-splice at the protein level.

272 Retrotransposons are eukaryotic mobile genetic elements that transpose by reverse transcription

273 Recently, we identified two mobile genetic elements that were closely associated with emm12

274 ogram can be circumvented by a protein-based genetic element, the [GAR(+)] prion, permitting simultan

275 mber of a previously unknown class of mobile genetic elements, the transpovirons.

276 stem CRISPR mediates defense against foreign genetic elements through two classes of RNA-guided nucle

277 tentially allows for more complex and longer genetic elements to be packaged into an AAV vector inclu

278 e, reflects the ability of the corresponding genetic elements to maintain mobility and persistence in

279 or for robust and sustained misexpression of genetic elements to test their function.

280 t our method links plasmids and other mobile genetic elements to their host species in a real microbi

281 meiosis provides an opportunity for selfish genetic elements to violate Mendel's law of segregation

282 evolutionarily conserved function in mobile genetic element (transposons) silencing and maintenance

283 To identify novel genetic elements underling the risk of inhibitor develop

284 ults of this study provide insights into the genetic elements underlying seed-size variation in maize

285 ormation by Ure2p produces the non-Mendelian genetic element [URE3] in Saccharomyces cerevisiae, maki

286 aea employ adaptive immunity against foreign genetic elements using CRISPR-Cas systems.

287 mune system defends microbes against foreign genetic elements via DNA or RNA-DNA interference.

288 uide strands derived from invading or mobile genetic elements, via an unknown pathway, to direct guid

289 l regulator (peaR); other previously unknown genetic elements were found as well.

290 DNA (class 2) transposons are mobile genetic elements which move within their 'host' genome t

291 Bacterial toxin-antitoxin (TA) systems are genetic elements, which are encoded by plasmid as well a

292 ported transmission of resistance via mobile genetic elements, which demonstrated greater diversity o

293 Flavin mononucleotide (FMN) riboswitches are genetic elements, which in many bacteria control genes r

294 sequence provides a thorough catalog of the genetic elements whose altered dosage perturbs developme

295 LINE-1 (L1) retrotransposons are mobile genetic elements whose extensive proliferation resulted

296 g biology now depends on the ad hoc reuse of genetic elements whose precise activities vary across ch

297 Genetic elements with desired properties were isolated u

298 lds identified ARGs likely located on mobile genetic elements, with up to 11 ARGs per plasmid-associa

299 and RA in B6.C3-Bbaa1 mice, formally linking genetic elements within Bbaa1 to pathological production

300 mal rap-phr genes are also present on mobile genetic elements, yet relatively little is known about t