ライフサイエンスコーパス: genetic linkage

1 milies showing the strongest evidence of the genetic linkage.

2 estimate variance components and to test for genetic linkage.

3 egate within populations and evolve in close genetic linkage.

4 12 that has numerous independent reports of genetic linkage.

5 been inconsistent for reports of significant genetic linkage.

6 ed genetic homogeneity to more easily reveal genetic linkage.

7 netic colocalization either by pleiotropy or genetic linkage.

8 otypes with other viral functions coupled by genetic linkage.

9 lelic frequency are no longer constrained by genetic linkage.

10 causal variants for single gene disorders is genetic linkage.

11 Here, genetic linkage analyses combined with exome sequencing

12 These findings support the utility of genetic linkage analyses for identification of novel ris

13 15q25-q26 to maximize the informativeness of genetic linkage analyses in a region where they previous

14 Genetic linkage analyses show a TBC1D1 R125W missense va

15 Genetic linkage analyses were performed with the use of

16 er the use of these markers for whole-genome genetic linkage analyses.

17 We performed genetic linkage analysis and candidate gene sequencing o

18 Genetic linkage analysis and complementation data establ

19 festing with calf weakness, we identified by genetic linkage analysis and exome sequencing a heterozy

20 We applied genetic linkage analysis and next-generation sequencing

21 vary among individuals of a species and that genetic linkage analysis can be used to identify quantit

22 Genetic linkage analysis can provide the means to identi

23 Genetic linkage analysis has identified loss-of-function

24 Genetic linkage analysis has identified regions of the g

25 Genetic linkage analysis identified 14 loci that were as

26 Genetic linkage analysis identified three loci with an L

27 We performed genetic linkage analysis in consanguineous families affe

28 ed in controlling hair texture, we performed genetic linkage analysis in six families of Pakistani or

29 We carried out a genetic linkage analysis in the extended DYT4 family tha

30 Genetic linkage analysis mapped loci with lod scores of

31 Localization of complex traits by genetic linkage analysis may involve exploration of a va

32 variation in gene expression, we carried out genetic linkage analysis of genomewide expression patter

33 mating in Leishmania, opening the way toward genetic linkage analysis of important traits and providi

34 ve gene, NKX2-5, has been identified through genetic linkage analysis of pedigrees with non-syndromic

35 Using genetic linkage analysis of proteoglycan-induced arthrit

36 ine skin model of chemical carcinogenesis in genetic linkage analysis of three independent Mus muscul

37 r describes MLIP, a multiprocessor two-point genetic linkage analysis system that supports statistica

38 , a HSL susceptibility gene), we conducted a genetic linkage analysis that included serotyping and ph

39 Genetic linkage analysis was performed in a family with

40 Two-point genetic linkage analysis was performed with MLINK and mu

41 Genetic linkage analysis was performed with the ALLEGRO

42 Subsequent genetic linkage analysis was used to define a region of

43 In this study, deep sequencing, genetic linkage analysis, and transcriptome data were us

44 Genetic linkage analysis, exome sequencing, tumor studie

45 rted to combine gene expression studies with genetic linkage analysis, leading to a new synergy betwe

46 We performed a genomewide scan and genetic linkage analysis, to identify loci associated wi

47 Using genetic linkage analysis, we earlier identified Dice1 as

48 Using genetic linkage analysis, we mapped a new locus for the

49 sults from the somatic deletion analysis and genetic linkage analysis, we were able to further narrow

50 e analyzed all 49 heritable phenotypes using genetic linkage analysis, with special emphasis on pheno

51 and 3 unaffected family members, followed by genetic linkage analysis.

52 g locus in the M. smegmatis chromosome using genetic linkage analysis.

53 ed LINKAGE package, to perform more powerful genetic linkage analysis.

54 Both genetic linkage and allelic association in the IDE regio

55 Together with genetic linkage and allelic association of IDE to Alzhei

56 ipoprotein receptor [VLDLR]) were tested for genetic linkage and allelic association, using two indep

57 Here, we present the results of applying genetic linkage and association analyses to neuropsychol

58 We have previously reported evidence for genetic linkage and association of AD on chromosome 10q2

59 Multiple genetic linkage and association studies identified three

60 ibility regions in human, rat and mouse, and genetic linkage and association studies pertaining to T1

61 study offers substantial power to carry out genetic linkage and association studies that use specifi

62 on as quantitative phenotypes, and conducted genetic linkage and association studies to map their reg

63 ring, heritability, and statistical power in genetic linkage and association studies.

64 genetic regions have been implicated through genetic linkage and association studies.

65 stimated by the EM algorithm, can be used in genetic linkage and association studies.

66 otype reconstruction is an essential step in genetic linkage and association studies.

67 igators are attempting to characterize using genetic linkage and association.

68 Genetic linkage and candidate gene studies have identifi

69 To enhance its genome studies involving genetic linkage and comparative mapping, a bacterial art

70 GCR provides an explanation for the colinear genetic linkage and expression of individual Hox genes w

71 There was considerable optimism that genetic linkage and genome-wide association (GWA) studie

72 lones becomes more prevalent with increasing genetic linkage and increasing population size, and it i

73 ar population genetics of the interaction of genetic linkage and natural selection.

74 emonstrate a robust strategy for integrating genetic linkage and physical contig maps with mitotic an

75 ical models that emphasize the importance of genetic linkage and pleiotropy in facilitating rapid div

76 y of taste receptor genes, hand in hand with genetic linkage and positional cloning studies, notably

77 to SPG20/spartin gene mutation (excluded by genetic linkage and SPG20/spartin sequence analysis).

78 he host genome, such as those resulting from genetic linkages and environmental stochasticity, have l

79 ies, comparative genomics, prior evidence of genetic linkage, and linkage disequilibrium.

80 The previous genetic linkage approach by microsatellite haplotyping w

81 minants of this variation can be mapped by a genetic-linkage approach.

82 combinations are theoretically possible; (2) genetic linkages are rare; (3) intragenic variability ma

83 iological processes giving rise to them, the genetic linkages associated with transcript abundance af

84 essing deficit found in the disease, by both genetic linkage at 15q14 and biochemical data.

85 is association was supported by family-based genetic linkage at a locus encompassing the DARC gene (g

86 n myogenesis remain unclear, owing partly to genetic linkage at the Myf5/Mrf4 locus and to rapid morp

87 Another important result is that the genetic linkage between a cue locus and modifier loci in

88 In small populations, genetic linkage between a polymorphic neutral locus and

89 Although genetic linkage between CG5762 and a neighboring causati

90 e conclude that our studies provide a direct genetic linkage between GI and chloroplast biogenesis, a

91 lysis of progeny from crosses revealed tight genetic linkage between HaABCC2 and resistance to Cry1Ac

92 et al. and Pergadia et al. find evidence for genetic linkage between major depressive disorder and th

93 a single genetic locus, resulting from tight genetic linkage between multiple functional loci.

94 ation is an effective mechanism to break the genetic linkage between neighboring sequences, thereby r

95 ent mice may explain earlier observations of genetic linkage between R7 family mutations and obesity

96 h mating type, discounting the hypothesis of genetic linkage between the A and B mating-type loci as

97 cted microevolutionary trend is explained by genetic linkage between the causal mutation underlying t

98 riation, yet they remain untapped due to the genetic linkage between the few useful alleles and hundr

99 ve at least one copy of A3H-I despite little genetic linkage between these genes.

100 -synuclein in these disorders is provided by genetic linkage between this gene and familial Parkinson

101 olocalization and fine-scale synteny suggest genetic linkage between traits within species and a cons

102 However, genetic linkage between ubiquilin-1 and AD has not been

103 This approach allowed us to establish genetic linkages between metabolites and genes.

104 ous studies have focused on the technique of genetic linkage, but new technologies and experimental r

105 ese pedigrees were evaluated for evidence of genetic linkage, by the maximum-likelihood parametric me

106 Natural selection and genetic linkage cause DNA segments to have genealogical

107 Efficient models for genetic linkage disequilibrium (LD) are needed to enable

108 determining the design features of two-stage genetic linkage disequilibrium studies that minimize the

109 KIR3DS1, in positive genetic linkage disequilibrium with KIR2DS1, had no effe

110 Population genetics, linkage disequilibrium, and association analys

111 Fine mapping further confirmed the genetic linkage effect and narrowed the region likely to

112 ctors in the B6 and C3H mouse model and that genetic linkages exist between body weight and lipoprote

113 ns, we conducted a series of correlation and genetic linkage experiments with eight D. melanogaster n

114 ith IC and their FDRs is consistent with the genetic linkage findings in families with PD.

115 assessed the impact of polarity at onset on genetic linkage findings previously detected in this sam

116 ilistic framework that combines the standard genetic linkage formalism with whole-genome molecular-in

117 ype 2 diabetes, based on previous reports of genetic linkage, functional molecular studies, expressio

118 We report on the completion of an autosomal genetic linkage (GL) map of the domestic cat (Felis silv

119 A genetic linkage group on chromosome 2 was selected under

120 romosomes that provide the structure for the genetic linkage groups and allow faithful replication, t

121 The rainbow trout genetic linkage groups have been assigned to specific ch

122 .) cytogenetic map that associates classical genetic linkage groups, molecular linkage groups, and a

123 Once genetic linkage has been identified for a complex diseas

124 ugh coordination of both gene expression and genetic linkage have been offered as genetic mechanisms

125 Positional cloning approaches based on genetic linkage have identified the disease genes in the

126 d the ordered-subset analysis to account for genetic linkage heterogeneity in the family-based data s

127 we conducted a whole genome scan to test for genetic linkage in 53 kindreds in which two or more sibl

128 A genome-wide screen for genetic linkage in a large family with an autosomal domi

129 mosome 20 is suggested by the observation of genetic linkage in several independent SLE family collec

130 inical correlates, familial aggregation, and genetic linkage in subjects with these features.

131 ndicating a prominent role for pleiotropy or genetic linkage in the divergence of this character comp

132 Studies have revealed a strong genetic linkage in the early-onset familial form (<60 ye

133 tool, capable of revealing otherwise cryptic genetic linkages in complex genetic diseases.

134 One titin locus lies within the genetic linkage interval and its expression is significa

135 f interactions between natural selection and genetic linkage is abundant not only in centromere- and

136 Genetic linkage is known to be one such feature, and her

137 This close genetic linkage is likely reflected in the strict correl

138 chromosome 6 (logarithm of the odds favoring genetic linkage [LOD] = 2.4), whereas chromosome 21 cont

139 Potato (Solanum tuberosum) has the densest genetic linkage map and one of the earliest established

140 We constructed a genetic linkage map between two divergent populations of

141 A genetic linkage map composed of 841 SSR, AFLP, and RAPD

142 me and used it, along with an integrated SSR genetic linkage map derived from four independent H. ann

143 We describe the first genetic linkage map for Daphnia pulex using 185 microsat

144 nalysis, we have developed a high-resolution genetic linkage map for T.gondii.

145 r tambaqui and constructed a high-resolution genetic linkage map from a full-sib family of 124 indivi

146 ato) synaptonemal complex 1 with a molecular genetic linkage map from the interspecific hybrid S. lyc

147 tion between chromosome size and size of the genetic linkage map in centimorgans for the genetic maps

148 , assembled de novo and then anchored to the genetic linkage map into seven pseudochromosomes.

149 nto channel catfish through introgression, a genetic linkage map is helpful.

150 omic substitution line was used to develop a genetic linkage map of 2B, evaluate the genetics of thre

151 In this study, we constructed a low-density genetic linkage map of Arabidopsis lyrata ssp. lyrata (A

152 Here we present a detailed genetic linkage map of ECB using AFLP and microsatellite

153 A transcriptome-based genetic linkage map of perennial ryegrass served as a sc

154 A genetic linkage map of the channel catfish genome (N=29)

155 A comprehensive genetic linkage map of the domestic cat X chromosome was

156 We constructed a joint SSR/RAPD genetic linkage map of the Helianthus petiolaris genome

157 To construct a genetic linkage map of the heterothallic yeast, Cryptoco

158 cted group, we constructed a high-resolution genetic linkage map of the homosporous fern model specie

159 A genetic linkage map of the horse consisting of 742 marke

160 udies using rhesus monkeys, we constructed a genetic linkage map of the rhesus genome.

161 combination rate data from a high-resolution genetic linkage map of the zebra finch.

162 A genetic linkage map ordered 1397 genome scaffolds on 12

163 Further, it was found that genetic linkage map regions containing phytochrome and H

164 A framework genetic linkage map was constructed and combined with lo

165 A high-density SNP-based genetic linkage map was constructed and integrated with

166 A genetic linkage map was constructed in a backcross famil

167 A molecular genetic linkage map was constructed using 148 amplified

168 In this project, a genetic linkage map was constructed using amplified frag

169 s mapped on a high-resolution intra-specific genetic linkage map were validated (11.6-27.3% PVE at 5.

170 erto not been possible, due to the lack of a genetic linkage map.

171 8 on the barley cv Dicktoo x barley cv Morex genetic linkage map.

172 A genetic-linkage map for chromosome 3A was developed by m

173 Comparison of the physical maps with the 3A genetic-linkage map localized the QTLs to gene-containin

174 Through genetic linkage mapping and whole-exome sequencing, we i

175 Genetic linkage mapping has identified more than 100 pla

176 High-density genetic linkage mapping is a valuable and effective meth

177 We then performed genetic linkage mapping of male-specific traits importan

178 Genetic linkage mapping of two crosses showed dominance

179 tosomal dominant transmission, and performed genetic linkage mapping using both parametric and non-pa

180 orted previously on the basis of comparative genetic linkage mapping.

181 in aquaporin-2 (Aqp2) in cph mutants through genetic linkage mapping.

182 otypes of resulting progeny were analyzed by genetic linkage mapping.

183 as expression QTL (eQTL) in two single-tree genetic linkage maps (F(1) hybrid paternal and E. grandi

184 Human genetic linkage maps are based on rates of recombination

185 High density genetic linkage maps are needed for marker assisted bree

186 stical comparison between two whole-genome F genetic linkage maps constructed from experimental inter

187 Construction of genetic linkage maps for nonhuman primate species provid

188 le sequence repeats (SSR)] we have generated genetic linkage maps for Physcomitrella.

189 oid hybrid speciation by generating detailed genetic linkage maps for three hybrid sunflower species,

190 and interactive method for the estimation of genetic linkage maps from DNA markers.

191 a and underscore the continued importance of genetic linkage maps in the post-genome era.

192 The estimation of genetic linkage maps is a key component in plant and ani

193 Construction of genetic linkage maps is an inevitable step for taking ad

194 used to construct comparative, single-tree, genetic linkage maps of an F(1) hybrid individual and tw

195 ject to recent positive selection; the first genetic linkage maps of resistance to malaria in experim

196 Consensus genetic linkage maps provide a genomic framework for qua

197 Comparative genetic linkage maps provide a powerful tool for the stu

198 Genetic linkage maps reveal the order of markers based o

199 The consensus genetic linkage maps were compared with each other and w

200 Improved genetic linkage maps were developed for S-population (Su

201 otyping-by-sequencing approach and generated genetic linkage maps with 6,291 and 3,297 single nucleot

202 difficult because only a few markers connect genetic linkage maps with physical maps.

203 e groups (genome assembly release Tcas_3.0), genetic linkage maps, the official gene set, Reference S

204 riendly computer program for construction of genetic linkage maps.

205 y were to generate high-density physical and genetic-linkage maps of wheat homoeologous group 3 chrom

206 Genetic linkage may result in the expression of multiple

207 heritability (variance-components methods), genetic linkage (multipoint quantitative trait analyses)

208 Theoretical work predicts genetic linkage of a gamete cell-size regulatory gene(s)

209 Collectively, our data suggest that the genetic linkage of AD in this set of chromosome 10-linke

210 Nonetheless, mounting evidence for genetic linkage of autism to the chromosome 17q11.2 regi

211 Genetic linkage of common complement polymorphisms to di

212 We conclude that the genetic linkage of critical physiological and virulence

213 In this cohort we found genetic linkage of disease (P = 0.00045) to chromosomal

214 The authors tested for genetic linkage of DSM-IV-diagnosed major depressive dis

215 underscores the importance of assessing the genetic linkage of HIV seroconversion events in HIV prev

216 We previously reported genetic linkage of loci controlling age-at-onset in Alzh

217 The overall LOD score for genetic linkage of markers to the region was 3.57.

218 The genetic linkage of rcoM with both aerobic (cox) and anae

219 Given the genetic linkage of the FANCJ-A349P allele to FA, we inve

220 autoimmune diseases and the well-established genetic linkage of these diseases with MHC class II.

221 The reasons for the tight genetic linkage of this receptor-ligand pair remain elus

222 We failed to identify genetic linkage of TNF release when considering each sti

223 Thus, these results demonstrate genetic linkages of hyperglycemia and body weight with S

224 Traditional approaches using genetic linkage or candidate gene analysis have often be

225 hree-factor crosses revealed little, if any, genetic linkage over distances of 500 to 600 bp, and lar

226 addition, evidence obtained from genome-wide/genetic linkage/proteomic/translational approaches revea

227 Marker positions on nine genetic linkage, radiation hybrid, and integrated maps o

228 y prohibits the systematic mapping of entire genetic linkage regions in order to find the polymorphis

229 d 643 arginine/glycine (R/G) occur in strong genetic linkage resulting in two common haplotypes (LSR

230 We report a genetic linkage scan of family X with an autosomal domin

231 t mutation screen, we conducted a genomewide genetic linkage scan.

232 s that are derived from (noisy) whole-genome genetic-linkage scans.

233 We have performed a genetic linkage screen in 16 pedigrees with FALS with no

234 hold levels of multiple mtDNA deletions, and genetic linkage, sequencing and expression analysis excl

235 Mania at onset substantially increased the genetic linkage signal on chromosome 16p (maximum lod sc

236 equilibrium that is required by the current genetic-linkage software.

237 Genetic linkage studies and candidate gene association s

238 Genetic linkage studies and exome sequencing have identi

239 microsatellites as the markers of choice for genetic linkage studies and many other studies of human

240 Previous genetic linkage studies and sequencing of plausible gene

241 Recent genetic linkage studies complement the existing evidence

242 hensive tag SNP maps that will be useful for genetic linkage studies in humans.

243 Genetic linkage studies in informative [C57BL/6JxSM/J]F2

244 Genetic linkage studies indicate that germline variation

245 We report on our initial genetic linkage studies of schizophrenia in the genetica

246 Our objective was to conduct genetic linkage studies of the type of OCD thought to ha

247 dney biopsy is frequently unhelpful, whereas genetic linkage studies or mutations in the UMOD gene ma

248 Genetic linkage studies showed that there was a high lev

249 These findings and recent genetic linkage studies strongly implicate NMDA receptor

250 Although genetic linkage studies support a critical underlying ro

251 Multiple genetic linkage studies support the hypothesis that the

252 y the gene responsible for HGF1, we extended genetic linkage studies to refine the chromosome 2p21-p2

253 ays, along with microsatellite analysis, and genetic linkage studies were performed.

254 e immunodeficiency and indicate the value of genetic linkage studies, thereby improving the genetic d

255 pported by many somatic deletion studies and genetic linkage studies.

256 s with 22q11 deletion syndrome (22q11DS) and genetic linkage studies.

257 f COS probands that is sufficient for use in genetic linkage studies.

258 with gene disruption in animal models or by genetic linkage studies.

259 ts were ascertained for two bipolar disorder genetic linkage studies: the University of Chicago, John

260 sideration of age at onset as a covariate in genetic-linkage studies may reduce genetic heterogeneity

261 for the sample sizes commonly used in human genetics linkage studies, minor QTL effects often go und

262 Together, the combination of our unbiased genetic linkage study and the in silico analysis positio

263 Evidence from a genetic linkage study had suggested a possible syndrome

264 We performed a genetic linkage study in 37 multigenerational human pedi

265 erviewing psychiatrists on 524 subjects in a genetic linkage study of BPI disorder.

266 The authors conducted a genetic linkage study of families that have both autism

267 P50 trait to serve as an endophenotype in a genetic linkage study of these families.

268 tegrates and refines the currently available genetic linkage, syntenic, and cytogenetic maps, and add

269 Genetic linkage tests reveal that silencing in the early

270 Here we present a method based on genetic linkage that can prospectively identify function

271 These traits showed genetic linkage to a short segment of chromosome 12p, in

272 B) on chromosome 17q21 demonstrates a strong genetic linkage to asthma, but its function in asthma is

273 to shape patterns of adaptive evolution via genetic linkage to beneficial mutations.

274 o a region on chromosome 11q23-24 that shows genetic linkage to BMI and type 2 diabetes in Pima India

275 AD shows genetic linkage to Chromosome 1q21.

276 ies, autoreactive CD4+ and CD8+ T cells, and genetic linkage to disease syntenic to that found in hum

277 a glucose binding protein (GBP) based on its genetic linkage to genes that are homologous to an ATP-b

278 stribution among bacterial species and their genetic linkage to known or predicted cell surface struc

279 e of toxin-associated PAAR-repeat motifs and genetic linkage to members of the valine-glycine repeat

280 er of genetic loci have shown association or genetic linkage to monogenic forms of POAG, the identifi

281 pontaneous swarming suppressors, inadvertent genetic linkage to swarming mutations, and auxotrophy.

282 the BALB.K and B10.BR strains to analyze for genetic linkage to the allogeneic BM engraftment phenoty

283 A number of autoimmune diseases have shown genetic linkage to the CTLA-4 locus.

284 ermatitis (AD) and psoriasis, share distinct genetic linkage to the Epidermal Differentiation Complex

285 , from haplotype structure and long-distance genetic linkage to the generation of new allelic variant

286 ossibly NS) segments, coupled with transient genetic linkage to the internal gene segments.

287 Genetic linkage to the K(ATP) locus was established usin

288 between the 2 genomes, both MAT loci exhibit genetic linkage to their respective centromere during me

289 s characterized for 113 strains via PCR, and genetic linkage was assessed.

290 The genetic linkage was confirmed and defined by microsatell

291 these endophenotypes; in the present study, genetic linkage was evaluated.

292 An apparently similar genetic linkage was observed in the rice genome.

293 ism and genes implicated without significant genetic linkage were excluded from this study.

294 andidate oncogene in human breast cancers by genetic linkage with activation of the poor-prognosis, w

295 that affect brain fiber architecture and its genetic linkage with cognitive function.

296 ttractive antiviral targets because of their genetic linkage with many other positions that we predic

297 ds] scores indicated suggestive evidence for genetic linkage with QTLs influencing urine arsenic meta

298 ily members located within intervals showing genetic linkage with SLE are TNFSF4 (also known as OX40L

299 lternatively spliced form of CTLA-4 that has genetic linkage with type I diabetes in the NOD mice.

300 has been observed across species, including genetic linkages with human cognitive abilities, PFC act