ライフサイエンスコーパス: genetic loci

1 asis refers to interactions between multiple genetic loci.

2 71 have a known molecular etiology or linked genetic loci.

3 ight in Europeans have identified nearly 180 genetic loci.

4 ts and the variation explained by identified genetic loci.

5 uency changes within a generation at 186,576 genetic loci.

6 y were shown to be able to detect additional genetic loci.

7 disorders (ASD) is attributed to hundreds of genetic loci.

8 s were subsequently performed for identified genetic loci.

9 s phenotype was mapped and controlled by 1-3 genetic loci.

10 ating disease that probably involves several genetic loci.

11 types suggest considerable overlap of causal genetic loci.

12 its, usually controlled by one or more major genetic loci.

13 ng meaningful fragments of two commonly used genetic loci.

14 unintended mutagenic changes at the targeted genetic loci.

15 e determined in part by variants at multiple genetic loci.

16 ration whose subtypes arise from 31 distinct genetic loci.

17 methyltransferases (MAMTs), encoded at four genetic loci.

18 tionally related or interacting genes across genetic loci.

19 controlling gene expression, and visualizing genetic loci.

20 ap (LRC), was constructed and contained 2498 genetic loci.

21 , the donor and the acceptor are at distinct genetic loci.

22 or the 13 drugs studied it was 238 across 18 genetic loci.

23 omal and mitochondrial DNA sequences of four genetic loci (16S rDNA, 28S rDNA, Cytochrome oxidase I a

24 strain; n = 654 total) to detect underlying genetic loci; 2) congenic mice (n = 23) to replicate the

25 roticism have identified up to 11 associated genetic loci (3,4) .

26 novel approach to unsupervised screening of genetic loci across RNA-seq cohorts.

27 At least two genetic loci affect the rate of Abeta-related cognitive

28 In an attempt to identify genetic loci affecting the size of the pDC compartment,

29 sociation studies identified 245 significant genetic loci, among which 95 genetically interacted with

30 viduals, in addition to identifying specific genetic loci and a SNP-by-SNP interaction implicated in

31 does it allow for interrelationships between genetic loci and across traits.

32 onstrated an association between 21 distinct genetic loci and BCC risk.

33 Distant genetic loci and biomarker-coding genes affect circulati

34 st associations between highly heterogeneous genetic loci and complex phenotypes.

35 us, natural LOF variants inform on essential genetic loci and demonstrate PRDM9 redundancy in humans.

36 To identify novel genetic loci and examine the influence of known loci on

37 ery rate approach, we increased discovery of genetic loci and identified two loci shared between neur

38 iants can pinpoint causal genes within known genetic loci and illustrate that applying the approach s

39 The method can be applied to all available genetic loci and is computationally fast.

40 and resolves their underlying combination of genetic loci and molecular mechanisms.

41 can for dental caries to identify associated genetic loci and nominate candidate genes affecting toot

42 We sought to investigate commonalities in genetic loci and pathways between allergy and autoimmune

43 he generation of persistence, maintenance of genetic loci and resistance to bacteriophages through ab

44 NG Capture-C can be used to analyze many genetic loci and samples simultaneously.

45 e located in previously discovered IOP, VCDR genetic loci and showed strongest associations with IOP

46 Many genetic loci and SNPs associated with many common comple

47 We identify 23 novel genetic loci, and 9 loci with convincing evidence of gen

48 s robust across different H. pylori strains, genetic loci, and bacterial growth phases.

49 bilistic framework to infer repeat sizes for genetic loci, and we used this software to infer repeat

50 ipts are highly similar, indicating that the genetic loci are already poised to transcribe these nove

51 A large number of genetic loci are associated with adult body mass index.

52 Multiple genetic loci are associated with development of both und

53 Multiple genetic loci are associated with IBD, but altered functi

54 igate biosynthetic pathways of SRRPs as SRRP genetic loci are highly conserved.

55 biosynthetic pathways of SRRPs because SRRP genetic loci are highly conserved.

56 Although more than 50 genetic loci are known [spastic gait (SPG)1 to -57], ove

57 ed to Plasmodium falciparum both to identify genetic loci as key targets of interventions and to deve

58 Sixty genetic loci associated with abdominal obesity, measured

59 Previous reports have implicated multiple genetic loci associated with AF, but the contributions o

60 Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one

61 We aimed to identify genetic loci associated with apoA-IV concentrations and

62 iation studies (GWAS) have revealed parasite genetic loci associated with artemisinin resistance.

63 To investigate genetic loci associated with atrial fibrillation in the

64 y and pleiotropy at several previously known genetic loci associated with blood cell traits in AAs.

65 genotype data, we have identified five novel genetic loci associated with BUA.

66 ized European and Asian subjects to identify genetic loci associated with CCT.

67 iation studies have previously identified 23 genetic loci associated with circulating fibrinogen conc

68 es by using FarmCPU R package to identify 17 genetic loci associated with cold tolerance.

69 Identifying the genetic loci associated with colorectal tumor formation

70 ome-wide association studies have identified genetic loci associated with cutaneous squamous cell car

71 ide association studies have discovered many genetic loci associated with disease traits, but the fun

72 Genetic risk scores were conducted based on genetic loci associated with either H. pylori colonizati

73 studies (GWAS) have successfully identified genetic loci associated with glycemic traits.

74 This study aims to discover new genetic loci associated with heart rate from Exome Chip

75 Identifying genetic loci associated with increased risk of acute kid

76 Multiple genetic loci associated with lipid levels have been iden

77 fixed effect meta-analysis to identify novel genetic loci associated with longitudinal change in lung

78 To identify genetic loci associated with measures of maternal metabo

79 antial progress has been made in identifying genetic loci associated with multifactorial disorders, i

80 e recent progress in the characterization of genetic loci associated with multiple sclerosis (MS) ris

81 netic association studies have identified 55 genetic loci associated with obesity or body mass index

82 Multiple genetic loci associated with obesity or body mass index

83 We have identified 6 novel genetic loci associated with P-wave duration and 6 novel

84 orphisms (SNPs) are increasingly used to tag genetic loci associated with phenotypes such as risk of

85 Finally, we identified genetic loci associated with plasma APOL1 levels and tes

86 -wide association studies (GWAS) to identify genetic loci associated with plasma levels of procoagula

87 ies (GWAS) have identified approximately 100 genetic loci associated with prostate cancer risk.

88 ciation studies (GWASs) have identified many genetic loci associated with raised serum urate concentr

89 tion studies (GWAS) have identified over 100 genetic loci associated with rheumatoid arthritis (RA),

90 rom over 40,000 individuals identified novel genetic loci associated with schizophrenia (SCZ) at geno

91 The goals of this study were to identify genetic loci associated with serum magnesium in an Afric

92 duals of European ancestry has identified 23 genetic loci associated with the estimated glomerular fi

93 SNP genotyping enabled localization of novel genetic loci associated with the pathophysiology of chil

94 pe association mapping was used to determine genetic loci associated with the presence of MME at 20 m

95 summary, this study nominates several novel genetic loci associated with the sight-threatening compl

96 ce, suggesting there are common and distinct genetic loci associated with these diseases, providing n

97 rcent mammographic density to identify novel genetic loci associated with this trait.

98 Here, we test these predictions using the genetic loci associated with total expression variation

99 The detection of genetic loci associated with variation in stem quality t

100 suggested that the interactions between two genetic loci at ADRB2 and PTGER4 is important in determi

101 ntensive investigation, with the classic HLA genetic loci being the best-characterized determinants.

102 We discuss recent findings on shared genetic loci between infectious and immune-mediated dise

103 ts from the availability of large numbers of genetic loci by detecting clusters of loci that are asso

104 not only allows more precise mapping of the genetic loci (called quantitative trait loci, QTL) that

105 Diversity at pathogen genetic loci can be driven by host adaptive immune selec

106 ysis framework in which hundred thousands of genetic loci can be tested simultaneously for associatio

107 ew studies now show that changes in the same genetic loci can drive the evolution of the same trait i

108 peans, and the issue of to what extent these genetic loci can predict blood lipid levels increases ov

109 plasmid, and the use of spatially separated genetic loci, can lead to molecules with virtually ident

110 Our findings suggest that some of the genetic loci conferring AMD susceptibility in East Asian

111 non-additive interactions between different genetic loci-constrains evolutionary pathways, blocking

112 a complete understanding of how these known genetic loci contribute to an increased disease risk in

113 ctor for lung cancer, and we defined several genetic loci contributing to DRC phenotype.

114 These data provide evidence for multiple genetic loci contributing to smoking cessation and thera

115 ation among laboratory mice, to identify the genetic loci controlling rotarod performance and its rel

116 raising two critical questions: (1) do these genetic loci converge on specific biological processes,

117 ls of G9a-dependent H3K9me2 at ILC3-specific genetic loci, demonstrating that G9a-mediated repression

118 These genetic loci deserve further investigation to elucidate

119 e is synthesized by four proteins encoded in genetic loci designated intercellular adhesion in Staphy

120 d robust identification of approximately 100 genetic loci determining plasma lipid parameters.

121 The genetic loci discovered are logical candidates for compo

122 documented that selection affected multiple genetic loci distributed across the genome, particularly

123 s retroviruses comprise millions of discrete genetic loci distributed within the genomes of extant ve

124 temporally tuned epigenetic modification of genetic loci during memory storage has revealed the rema

125 that several previously known WBC-associated genetic loci (e.g. the African Duffy antigen receptor fo

126 Here we characterize three genetic loci encoding type IV methylation-dependent rest

127 de association study (GWAS) identifying >100 genetic loci, encompassing a total of 341 protein-coding

128 Known genetic loci explain only a small proportion of the fami

129 ed GWAS to obtain 297 SNP associations at 11 genetic loci, explaining up to 36% of the variation of 1

130 We identified genetic loci for active tameness through selective breed

131 nducted a GWAS and meta-analysis to identify genetic loci for aPTT and PT.

132 ur results nearly double the number of known genetic loci for atrial fibrillation, provide insights i

133 de association studies for identifying novel genetic loci for blood pressure, lipids, hypertension, e

134 These results suggest that genetic loci for BMI can vary in their effects across th

135 Genetic loci for body mass index (BMI) in adolescence an

136 mportance of variants in the IL18R1 and IL18 genetic loci for broad-based smallpox vaccine-induced ad

137 h healthy controls and suggest several novel genetic loci for CHD.

138 Hence, for the current study genetic loci for coronary artery calcification and serum

139 ntial mutagens, environmental conditions, or genetic loci for effects on a broad set of mutational ev

140 gbird and the ability to obtain thousands of genetic loci for many individuals permit the investigati

141 Aiming to identify novel genetic loci for pigmentation and skin cancer, we conduc

142 association studies have identified several genetic loci for PR interval, but it remains to be deter

143 Over 40 genetic loci for retinitis pigmentosa have been identifi

144 scale analyses have begun to identify robust genetic loci for schizophrenia, providing an opportunity

145 phism (SNP) genotyping array to identify the genetic loci for SET and SDW through a genome-wide assoc

146 systems genetics framework to integrate risk genetic loci from the largest body mass index (BMI) geno

147 To identify genetic loci/genes that regulate female sexual maturatio

148 Over 100 genetic loci harbor schizophrenia-associated variants, y

149 Many detected genetic loci harbor variants that associate with multipl

150 Fourteen genetic loci have been associated with atrial fibrillati

151 Multiple genetic loci have been associated with blood lipid level

152 To date, numerous genetic loci have been associated with height in individ

153 ed for, and to date only a limited number of genetic loci have been definitively implicated.

154 Only few genetic loci have been identified as robustly associated

155 However, very few genetic loci have been identified, and the underlying me

156 hly heritable, yet relatively few associated genetic loci have been replicated.

157 esium levels are highly heritable, and a few genetic loci have been reported involving regulation of

158 Although a small number of genetic loci have been reported to be associated with va

159 Over 100 associated genetic loci have been robustly associated with schizoph

160 Genetic loci have not yet been identified by genome-wide

161 It has been estimated that >1,000 genetic loci have yet to be identified for breast cancer

162 and shoot growth characteristics revealed 10 genetic loci highly associated with the responsiveness o

163 Genetic loci identified by conditional false discovery r

164 enic risk score for schizophrenia across 108 genetic loci identified by the Psychiatric Genomics Cons

165 TTK and other genetic loci identified in our study may contribute to t

166 The additional genetic loci identified in this large meta-analysis of c

167 tly unknown despite the increasing number of genetic loci identified that increase disease risk.

168 ggregate effect on blood pressure of all the genetic loci identified to date is small.

169 Despite thousands of genetic loci identified to date, a large proportion of g

170 low-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two

171 Ten genetic loci in 7 genes [complement factor H (CFH), age-

172 is large-scale GWAS, we identified two novel genetic loci in association with the rate of change in F

173 y, we identified and characterized two novel genetic loci in C. diphtheriae that encode factors that

174 This GWAS of the FHS cohort has identified genetic loci in HLA genes that might have a role in the

175 pecific sequence variants in these and other genetic loci in larger populations and in unusual hydrox

176 These findings suggest that rs5068 or genetic loci in linkage disequilibrium might affect susc

177 pecific ESCC microRNA family arises from two genetic loci in mammals: miR-290/miR-371 and miR-302.

178 nomic approaches have implicated hundreds of genetic loci in neurodevelopmental disorders and neurode

179 Yeast (SATAY) allows one-step mapping of all genetic loci in which transposons can insert without dis

180 We identified six genetic loci, including five novel loci, significantly a

181 death in PD is largely unknown, but several genetic loci, including leucine-rich repeat kinase 2 (LR

182 al variation and individual taxa at multiple genetic loci, including the VDR gene (encoding vitamin D

183 Hundreds of genetic loci increasing risk for neuropsychiatric disord

184 Known genetic loci influencing blood cell production account f

185 Using LTA analysis, we identified genetic loci influencing BP.

186 Recent studies have identified many genetic loci influencing circulating lipid levels and st

187 GWASs for discovery and characterization of genetic loci influencing hematologic traits.

188 report the most comprehensive exploration of genetic loci influencing human metabolism thus far, comp

189 e performed association analyses to identify genetic loci influencing lipid concentrations in African

190 We aimed to identify additional genetic loci influencing SF in type 1 diabetes (T1D) thr

191 Despite a significant heritability, few genetic loci influencing WMH burden have been identified

192 ity traits and schizophrenia by highlighting genetic loci involved in their common genetic etiology.

193 udies (GWASs) have identified a multitude of genetic loci involved with traits and diseases.

194 We also identified several novel genetic loci involving or regulating hematopoietic trans

195 nt association with pigmented spots at three genetic loci: IRF4 (rs12203592, P=1.8 x 10(-27)), MC1R (

196 s analysis of mutation frequency at multiple genetic loci is feasible.

197 We identified 2 genetic loci (kininogen 1 and kallikrein B) influencing

198 he temporal context of selection on specific genetic loci known to differentiate modern domestic chic

199 Observed associations were not modified by genetic loci known to influence fasting glucose or insul

200 We identified ten genetic loci known to influence proximal DNA methylation

201 abolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence m

202 urrent study are to examine whether genes in genetic loci linked to fat distribution can be linked to

203 ourteen candidate enhancers, representing 10 genetic loci, mapped to sites associated with biological

204 Among the 3 genetic loci most strongly associated with AF, the chrom

205 6.Aec1Aec2 mice, which are known to have the genetic loci necessary for developing a SS-like disorder

206 0 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, i

207 ells in a nonrandom fashion, with particular genetic loci occupying distinct spatial regions.

208 gregation of most newly replicated bacterial genetic loci occurs sequentially soon after replication.

209 Through a genome-wide screen for the genetic loci of M. tuberculosis that inhibit MHC class I

210 ide association investigation has identified genetic loci of major and minor effect.

211 To evaluate the impact of the established genetic loci on BMI at these young ages, we examined dif

212 evaluate the effects of glycemia-associated genetic loci on islet function in vivo and in vitro.

213 No robustly associated genetic loci or variants for childhood intelligence have

214 y encoded adjacent to shell protein genes in genetic loci, or operons.

215 ide polymorphisms (SNPs) in thirty-seven key genetic loci previously associated with dyslipidemia in

216 Across the 9 phenotypes, variants in 4 genetic loci reached genome-wide significance: rs4552931

217 4 region was used to significantly refine genetic loci regulating diabetogenic B and CD4 T cell ac

218 o date in African Americans, we identified 4 genetic loci related to left ventricular mass, intervent

219 which proved efficient in detecting numerous genetic loci related with various traits, interaction-ba

220 These genetic loci represent the best evidence of genetic infl

221 er, these findings not only expand the known genetic loci required for ESX-1 secretion in M. marinum

222 To map the genetic loci responsible for female-mediated nonrandom m

223 To map the genetic loci responsible for female-mediated nonrandom m

224 ve proven a useful technique for identifying genetic loci responsible for natural variation in A. tha

225 Although variation and genetic loci responsible for RNA expression levels have

226 th limited taxon sampling and a small set of genetic loci, resulting in weakly supported (and sometim

227 ed information on alleles and genotypes of 4 genetic loci, rs3766031 (ATPIB1), rs5443 (GNB3), rs5522

228 a mapping approach that is able to identify genetic loci segregating within the lines, we identified

229 Here we aimed to identify specific genetic loci shared between schizophrenia and the Big Fi

230 The genetic loci showed associations with putative signaling

231 We identified 39 genetic loci specifically associated in cis with activat

232 In summary, eight genetic loci that account for approximately 29% of the v

233 ssociation study permitted identification of genetic loci that affect most of the target flavor chemi

234 identified and functionally verified several genetic loci that affect the expression of cytolytic tox

235 tives yields important fitness benefits, but genetic loci that allow recognition of unfamiliar kin ha

236 Our findings reveal two genetic loci that are associated with acute kidney injur

237 wide association studies have revealed novel genetic loci that are associated with coronary heart dis

238 patial-clustering methodology, assuming that genetic loci that are associated with the target phenoty

239 typically find only a minor fraction of the genetic loci that are predicted to affect variation.

240 ts a systematic approach to broadly identify genetic loci that can be used to improve membrane protei

241 ase of unprecedented progress in identifying genetic loci that cause variation in traits ranging from

242 pression Quantitative Trait Loci (eQTL), the genetic loci that contribute to heritable variation in g

243 ation studies provide a tool for discovering genetic loci that contribute to variations in alcohol co

244 eQTLs are genetic loci that correlate with RNA transcript levels.

245 and specificity to query single cells at the genetic loci that drive cancer progression, thereby enab

246 Genetic loci that ensure productivity in challenging env

247 We identified 12 new genetic loci that exceeded genome-wide significance, imp

248 m three independent LGG datasets to identify genetic loci that govern tumor aggressiveness and poor s

249 We identified 4 novel genetic loci that implicate inflammatory and glial proli

250 We identify 12 new genetic loci that implicate known components of the circ

251 allowed the mapping of recessively acting B6 genetic loci that in the proper context contribute to di

252 The common genetic loci that independently influence the risk of ty

253 (GWASs) are commonly used for the mapping of genetic loci that influence complex traits.

254 introduce a powerful method for identifying genetic loci that influence protein expression in the ye

255 ome-wide association studies have identified genetic loci that jointly make a considerable contributi

256 es in sensory systems and through changes in genetic loci that likely act downstream of sensory input

257 This study nominates several novel genetic loci that may be associated with severe diabetic

258 n unbiased linkage analysis to determine the genetic loci that may limit the size of the NK cell comp

259 dystrophy and cardiomyopathy, we identified genetic loci that modify muscle pathology and cardiac fi

260 genes encoding these enzymes are located in genetic loci that orchestrate the depolymerization of ye

261 wide association studies identified over 100 genetic loci that significantly associate with schizophr

262 Despite intense research efforts, genetic loci that substantially account for disease heri

263 We consider the number of genetic loci that underlie ASDs and the relative contrib

264 ed here aid in understanding the susceptible genetic loci that underlie pathogenic mechanisms of age-

265 CoGeLs were also screened to identify genetic loci that work synergistically to create the con

266 We targeted three unlinked genetic loci: the mitochondrial control region, a gene a

267 This study aims to identify new CAD genetic loci through a large-scale linkage analysis of 2

268 ded the importance of several RBC-associated genetic loci to AAs and identified allelic heterogeneity

269 hole body lean body mass and find five novel genetic loci to be significantly associated.

270 ciation studies have linked approximately 60 genetic loci to coronary risk.

271 The link of genetic loci to specific tumor subtypes may have relevan

272 teins, we observed a dramatic shift of their genetic loci toward the membrane upon induction.

273 sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimat

274 ion genomics are being leveraged to identify genetic loci under selection in the malaria parasite and

275 Genetic loci undergo both stochastic motion around their

276 e become an important method for mapping the genetic loci underlying complex phenotypic traits in man

277 layed a fundamental role in the discovery of genetic loci underlying human diseases.

278 in on X chromosome (DCX) is one of two major genetic loci underlying human lissencephaly, a neurodeve

279 grade inflammation and identified many novel genetic loci underlying inflammation that may serve as t

280 ion by enumerating the relative abundance of genetic loci unique to the plasmid and the chromosome.

281 evidence of disease association at five new genetic loci upon meta-analysis of all patient collectio

282 We conducted a follow-up study of these 23 genetic loci using a population-based sample of 1,018 un

283 uced changes in RSA were associated with 100 genetic loci using genome-wide association studies.

284 The genetic loci were amalgamated into a weighted genetic ri

285 The top genetic loci were explained between 1.7% (Ang-2) and 11.

286 The spire and cappuccino genetic loci were first identified as maternal effect ge

287 Four of the identified genetic loci were significantly associated with gene exp

288 Type 2 diabetes-associated genetic loci were significantly associated with higher r

289 Identifying genetic loci where DNA methylation is associated with ch

290 276 population) and 21 (Kali Aus population) genetic loci, which were contributed by both the traditi

291 usly sequenced genomes, pan-PCR identified 6 genetic loci whose presence or absence was capable of di

292 the diploid F. cylindrus genome consists of genetic loci with alleles that are highly divergent (15.

293 dy size and that anthropometric traits share genetic loci with developmental and psychiatric disorder

294 ng the Metabochip, we identified three novel genetic loci with large effects (30-40%) on GLP-1-stimul

295 h widespread changes in DNA methylation (187 genetic loci with P < 1 x 10(-7), range P = 9.2 x 10(-8)

296 It is also primarily caused by genetic loci with parent-of-origin effects, suggesting a

297 and bone mass density in children, and show genetic loci with pleiotropic effects on both traits.

298 hat our approach works particularly well for genetic loci with very small minor allele frequencies.

299 growth in xylose is governed by at least two genetic loci, within which we identified the responsible

300 bearing one or more mutant alleles at other genetic loci without the need for lengthy backcrossing.