ライフサイエンスコーパス: genetic method

1 rong and advocated an alternative population genetic method.

2 GRIM-19, a novel growth suppressor, using a genetic method.

3 is regularly reported and investigated using genetic methods.

4 from the retina in a sustained manner using genetic methods.

5 in motor neuron diversification using mouse genetic methods.

6 using biochemical, molecular biological, and genetic methods.

7 notypic and molecular chemical and molecular genetic methods.

8 iac p38 MAPK activity by pharmacological and genetic methods.

9 so far using predominantly immunological and genetic methods.

10 igh-resolution ocean modeling and population genetic methods.

11 ombination has been obtained using indirect, genetic methods.

12 m was investigated using cell biological and genetic methods.

13 cortical interneurons using fate mapping and genetic methods.

14 was identified and mapped using quantitative genetic methods.

15 ifficult to study by existing biochemical or genetic methods.

16 vical lymph node, and spleen using molecular genetic methods.

17 with PCNA was established by biochemical and genetic methods.

18 re characterized by phenotypic and molecular genetic methods.

19 combination of biochemical, biophysical and genetic methods.

20 ill be increasingly accompanied by molecular genetic methods.

21 ogens were largely hindered by an absence of genetic methods.

22 ors that can be targeted to cell types using genetic methods.

23 ed neural fates in the brain without complex genetic methods.

24 vivo was assessed using pharmacological and genetic methods.

25 ), promoter reporter analysis, and molecular genetic methods.

26 remain difficult to classify by traditional genetic methods.

27 e, or exceedingly difficult, using classical genetic methods.

28 idated as a drug target by both chemical and genetic methods.

29 tates a re-evaluation of existing population genetic methods.

30 have been isolated by the application of two genetic methods.

31 gene of influenza virus A/WSN/33 by reverse genetic methods.

32 kinase gene has been identified by a reverse genetics method.

33 man and animal influenza vaccines by reverse genetics methods.

34 1 (nad1) mutant was identified using reverse genetics methods.

35 stablished using phylogenetic and population genetics methods.

36 ening approach involves a recently described genetic method allowing efficient production of mosaic f

37 The application of a second generation of genetics methods allows the dissection of moderate and m

38 Using molecular genetic methods and bioinformatics, we verify the intera

39 heir expression pattern, both by traditional genetic methods and by recent high-throughput expression

40 By analyzing viruses constructed by reverse-genetic methods and containing recombinant HAs, we estab

41 Using population genetic methods and epidemiological observations, we rep

42 J (V beta(c)) backcross mice using Mendelian genetic methods and immunized them with acetylcholine re

43 Using genetic methods and mass spectrometry, we demonstrate th

44 have been identified by both biochemical and genetic methods and systematic attempts to understand th

45 population with the cell-type-selectivity of genetic methods and the temporal control of pharmacology

46 ntified a mutation in nanos1 using a reverse genetics method and show that young female nanos mutants

47 Recent technological advances in reverse genetics methods and limitations of the conventional pro

48 Although genetic methods are available to identify novel protein-

49 Behavioral-genetic methods are based on a solid foundation of theor

50 However, these genetic methods are laborious, and limited for quantitat

51 e focus on the mouse, in which molecular and genetic methods are most advanced.

52 mpletion of the genome projects, alternative genetic methods are needed where large numbers of genes

53 Because genetic methods are not available for amphibian studies,

54 tudies using new cytological, molecular, and genetic methods are shedding some light on the processes

55 yperdiversity) mean that standard population genetics methods are not trustworthy.

56 Inhibition of JNK by chemical or genetic methods attenuated NaBT-induced PTEN expression.

57 By using the powerful genetic methods available for examining behavior in frui

58 Genetic methods available in mice are likely to be power

59 hematopoiesis in zebrafish, discuss various genetic methods available in the zebrafish model for stu

60 Results suggest the potential for using genetic methods based on microsatellite loci data to com

61 Genetics methods based on homologous recombination are u

62 d is distinguished from conventional forward genetic methods because it permits (1) unbiased declarat

63 substrates of kinases has proven elusive to genetic methods because of the tremendous redundancy and

64 in (FMG) into tumor cells, and incorporate a genetic method by which true hybrid formation can be una

65 We describe here a genetic method (called EGUF/hid) that uses both the GAL4

66 Here, using the cell-type selectivity of genetic methods, circuit mapping, and behavior assays, w

67 Using forward genetic methods combined with comparative genome hybridi

68 Molecular genetic methods confirmed the role of the Ivory Coast va

69 The availability of genetic methods, coupled with its physiological and meta

70 This means that many statistical genetic methods developed for searching for susceptibili

71 The new genetic methods developed in this work will promote expe

72 Classical genetic methods, driven by phenotype rather than hypothe

73 We report a new chemical genetic method for creating bivalent ligands of protein

74 al lesions in genomes (TILLING) is a reverse-genetic method for identifying point mutations in chemic

75 Here, we report a chemical genetic method for regulating the catalytic activity of

76 The AlstR/AL system is therefore a promising genetic method for selective and quickly reversible sile

77 ence of microbial opsin engineering, modular genetic methods for cell-type targeting and optical stra

78 ovides a synopsis of the currently available genetic methods for Chlamydia along with a comparison to

79 Structure methods are highly used population genetic methods for classifying individuals in a sample

80 It has been suggested that pharmacologic or genetic methods for enhancing glucokinase (GK) enzymatic

81 and Chinese rhesus macaques have encouraged genetic methods for identifying genetic differences betw

82 along with the development of new population genetic methods for identifying selection in sequence da

83 Genetic methods for neural circuit manipulation in mice

84 Genetic methods for neuronal silencing have great promis

85 In reviewing genetic methods for studying life history trade-offs, we

86 There is a critical need for genetic methods for the inducible expression of transgen

87 sruptive effect on widely applied population genetics methods for inferring recombination rates, for

88 tion strategy to previously reported reverse genetics methods for RV may enhance the efficiency of re

89 an partially substitute for powerful forward genetic methods (genome-independent) that have advanced

90 The application of genetic methods has begun to provide new insights into h

91 incapable of transmitting pathogens through genetic methods has long been a goal of vector geneticis

92 A new reverse genetics method has been developed to identify and isola

93 Yeast molecular genetic methods have been instrumental in the functional

94 Quantitative genetic methods have demonstrated adaptive variation in

95 Although biochemical and genetic methods have detected many activator-transcripti

96 ing formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS).

97 In this study, we apply population genetic methods in a novel manner to determine whether m

98 y analyses, biochemical studies, and in vivo genetic methods in Drosophila.

99 Results from studies using molecular and genetic methods in humans and rodents suggest that brain

100 These studies illustrate the utility of genetic methods in M. maripaludis and show the enhanced

101 We have used genetic methods in Methanococcus maripaludis to study ni

102 In contrast, powerful genetic methods in the fruit fly Drosophila allow effici

103 dvances that have been made, using primarily genetic methods, in identifying molecules responsible fo

104 ently, the combination of flow cytometry and genetic methods, in which modifications of the replicati

105 Applications of this genetic method include phenotypic analysis of existing m

106 These mutants were mapped using classical genetic methods, including backcrosses to demonstrate re

107 ts to engineer the cloned genome by standard genetic methods involving the URA3/5-fluoroorotic acid (

108 or genes in solid tumors by classical cancer genetics methods is difficult and slow.

109 rmined apolipoprotein(a) isoform size with a genetic method (kringle IV type 2 [KIV2] repeats in the

110 The goal of this work was to develop a genetic method of determining the serotype of Bcc isolat

111 Thus, our genetic method of screening for pol beta mutator mutants

112 There are four standard genetic methods of covalently tagging a protein with a f

113 Genetic methods of manipulating or eradicating disease v

114 e responsible for these disorders, a forward genetics method of gene discovery was used to identify a

115 Behavioural genetic methods offer a largely untapped means to invest

116 ken as hypotheses to be tested by additional genetic methods, particularly in species for which detai

117 the two proteins by biochemical and reverse genetics methods paves the way for rational drug design

118 Genetic methods provided lines lacking ISA1 or ISA2.

119 printed by a combination of well-established genetic methods (pulsed-field gel electrophoresis [PFGE]

120 cording phenotype, which begins with forward-genetic methods represented by random physical and chemi

121 The cloning of E(var)3-9 by classical genetic methods revealed that it encodes a protein with

122 to manipulate the HAC vector by recombinant genetic methods should allow us to further define the el

123 are experimentally validated by physical and genetic methods, showing that cells exploit a mechanism

124 rresponding recombination rate by population genetic methods tends to be inflated.

125 To evaluate this assumption, we developed a genetic method that can inducibly deplete targeted prote

126 Effective genetic methods that allow systematic study of anti-apop

127 analyzed using recently developed population genetic methods that have enabled the estimation of tran

128 that result can be detected using population genetic methods that test for signatures of balancing se

129 Here we demonstrate with genetic methods that the Drosophila peripheral nerve is

130 By using genetic methods, the effects of bile and bile acids were

131 werful new microchemical tools and molecular-genetic methods, three new classes of proteins have been

132 We report the use of a genetic method to block synaptic activity acutely in the

133 We describe a yeast genetic method to detect and analyze RNA-protein interac

134 lustrates the ability of our novel landscape genetic method to detect the impacts of relatively recen

135 We have developed a genetic method to determine the active orientation of di

136 A yeast-based genetic method to discover novel nuclear receptor intera

137 nisms of polymerase fidelity, we developed a genetic method to identify mammalian pol beta mutator mu

138 I used a genetic method to investigate the location and function

139 We developed a genetic method to isolate other mutant DnaAs that circum

140 We used a genetic method to label pre and postsynaptic sites in gr

141 Here we apply a chemical genetic method to rapidly and selectively inactivate a m

142 The yeast two-hybrid system is a powerful genetic method to screen cDNA libraries to identify prot

143 Here we use a genetic method to selectively inhibit neurotransmission

144 A powerful genetic method to study protein-protein interaction is t

145 Here we have used genetic methods to address these issues.

146 To this end, we are pursuing genetic methods to alter the cell recognition domain of

147 the malignant cell populations and molecular genetic methods to assay for somatic loss of the normal

148 We applied quantitative genetic methods to assess the heritability of RA and to

149 a coli genetic system that permits bacterial genetic methods to be applied to the study of essentiall

150 Here, we use both physical and genetic methods to characterize the trapped DNA.

151 In this study we use genetic methods to compare dispersal patterns in a Briti

152 Here, we use standard association genetic methods to correlate 3563 single nucleotide poly

153 arkable progress has been made in developing genetic methods to detect small molecules in vivo, many

154 he local response to cell death by using two genetic methods to elevate cell death rates.

155 Use of genetic methods to estimate effective population size (N

156 Use of single-sample genetic methods to estimate effective population size ha

157 between these hypotheses, we used population genetic methods to estimate larval dispersal among five

158 Here, we use molecular and genetic methods to examine the functional activity of th

159 Here, we use genetic methods to explore the relationship between C. e

160 sms, limiting the effectiveness of classical genetic methods to identify miRNA functions.

161 and as such it has not been possible to use genetic methods to introduce oncogenic alterations into

162 tick cells in vitro when it is coupled with genetic methods to isolate and complement B. burgdorferi

163 mily 2 PspA (from strain TIGR4) by molecular genetic methods to make an isogenic pair of strains expr

164 Researchers have used chemical synthesis and genetic methods to make these proteins and more: protein

165 ere, we use a combination of biochemical and genetic methods to map the p7 interaction site to within

166 We used molecular genetic methods to re-evaluate subspecies partitions and

167 Here, we used genetic methods to remove AChRs selectively from muscle.

168 ing techniques are combined with traditional genetic methods to scrutinize and compare dynamic proces

169 dify a naturally occurring circuit, by using genetic methods to select functional circuits and evolve

170 We used chemical genetic methods to show that drug-mediated transactivati

171 In the present study, we have used genetic methods to study the role of membrane or soluble

172 of virus allows the application of DNA-based genetic methods to the study of PaV structure and assemb

173 We used this reverse genetics method to generate a panel of viruses with chim

174 loop 1 insertion mutant, and we used reverse-genetics methods to confirm the identities of suppressor

175 e have been major developments of population genetics methods to estimate both rates of recombination

176 d phenotypes and enable molecular population genetics methods to finely resolve uncharacterized funct

177 A genetic method was developed to detect such structures i

178 he activity of mPFC neurons using a chemical-genetic method was sufficient to convert the resilient b

179 The application of population genetic methods was demonstrated on a particularly abund

180 Using various biochemical and genetic methods we further demonstrate that Bicoid molec

181 Using a bump-and-hole-based chemical-genetic method, we have rapidly and selectively manipula

182 Here, by using both biochemical and genetic methods, we demonstrate the existence of EndA-me

183 a combination of biochemical, molecular, and genetic methods, we have found that the phylogenetically

184 Using both biochemical and genetic methods, we have isolated a novel subunit of the

185 Using an array of biochemical and molecular genetic methods, we mapped the interaction interface bet

186 Using genetic methods, we show that lon-1 lies downstream of t

187 Using genetic methods, we show that ryr-1 is the previously id

188 Pharmacological, molecular, and genetic methods were used to further understand the role

189 Genetic methods were used to trap pilus subunits during