ライフサイエンスコーパス: genetic predisposition

1 ssociation that is likely to be moderated by genetic predisposition.

2 pulations, such as TH17 cells, influenced by genetic predisposition.

3 rarely elsewhere in the world, suggesting a genetic predisposition.

4 , and they are thought to be associated with genetic predisposition.

5 f consuming SSBs owing to their ethnicity or genetic predisposition.

6 g ER (ER positive), including differences in genetic predisposition.

7 indicating sporadic IPF occurs in those with genetic predisposition.

8 Hmong affected are unclear, but may involve genetic predisposition.

9 should consider age, training intensity, and genetic predisposition.

10 roportion of young CRC cases associated with genetic predisposition.

11 ial background, which would be evidence of a genetic predisposition.

12 RA and GPA may arise from a similar genetic predisposition.

13 viduals carrying HLA-DQ2 or HLA-DQ8 as major genetic predisposition.

14 , and lack of exercise, but it also involves genetic predisposition.

15 ve stress, abnormal protein aggregation, and genetic predisposition.

16 interplay between environmental factors and genetic predisposition.

17 that smoking-induced dopamine release has a genetic predisposition.

18 44 of 153 patients (29%) had an identifiable genetic predisposition.

19 d nonallergic reactions (NARs) influenced by genetic predisposition.

20 combined effects of an exogenous trigger and genetic predisposition.

21 its in populations with a known or suspected genetic predisposition.

22 iduals whose cancers arise in the setting of genetic predisposition.

23 d properties, gut microbiota, and individual genetic predisposition.

24 f a cell to its environment as a function of genetic predisposition.

25 rent COPD subtypes, which may have different genetic predispositions.

26 heir supportive environment based upon their genetic predispositions.

27 so differ between individuals with different genetic predispositions.

28 Genetic predisposition accounts for most of the risk of

29 Ethnic background and genetic predisposition affect the occurrence and outcome

30 attributed to a number of factors, including genetic predisposition, age and different environmental

31 ans have been studying risk factors, such as genetic predisposition, aging, obesity, and joint malali

32 s were combined in 4 scores as indicators of genetic predisposition; all SNPs in a general score and

33 tal regions, suggesting a mechanism by which genetic predisposition alters reward processing not only

34 rise, at least in part, from a glutamatergic genetic predisposition and a deficit in short-term habit

35 is believed to arise from an interaction of genetic predisposition and adverse environmental factors

36 ld be seen as the result of a combination of genetic predisposition and an immune-mediated two-hit mo

37 eloping atrial fibrillation (AF) considering genetic predisposition and clinical risk factor burden i

38 Several hypotheses exist, implicating genetic predisposition and dysregulation of immunity, bu

39 acity to control for the effects of variable genetic predisposition and early environmental exposures

40 ease susceptibility is jointly determined by genetic predisposition and environmental contribution.

41 ity is the consequence of the combination of genetic predisposition and environmental effects, such a

42 is driven by a complex relationship between genetic predisposition and environmental exposures.

43 ores the importance of the interplay between genetic predisposition and environmental factors in full

44 ve several causal pathways, including common genetic predisposition and environmental factors, and in

45 se that results from the interaction between genetic predisposition and environmental factors.

46 ing disease that arises on the background of genetic predisposition and environmental risk factors, s

47 nknown but postulated to be a combination of genetic predisposition and environmental triggers.

48 findings suggest that multiple events (i.e., genetic predisposition and HIV-1 immune dysregulation) m

49 our data indicated that associations between genetic predisposition and obesity traits were stronger

50 We analyzed the interaction between genetic predisposition and the intake of sugar-sweetened

51 held hypothesis is that interactions between genetic predisposition and Western-type lifestyle contri

52 CPCs derived from aged patients with HF with genetic predispositions and comorbidities of chronic dis

53 and mouse models have emphasized the role of genetic predispositions and how they affect interactions

54 k factors (such as obesity, tobacco use, and genetic predisposition) and HIV-specific and ART-specifi

55 ious pathogens, anatomy, immunologic status, genetic predisposition, and environment.

56 y include lifestyle factors such as smoking, genetic predisposition, and specific comorbidities such

57 Psoriasis is a disease with a strong genetic predisposition, and the gene encoding CIKS has r

58 tment exposures, comorbid health conditions, genetic predispositions, and lifestyle behaviors.

59 serological markers, pathogenic mechanisms, genetic predispositions, and therapies similar to the rh

60 Biological factors, including genetic predisposition, appear to play a role in the dev

61 reoperative evaluation of patients including genetic predisposition, appear to provide initial opport

62 and anatomy, dietary composition, housing or genetic predisposition are discussed in this paper.

63 Ethnicity and genetic predisposition are partly responsible for this h

64 Smoking, drinking alcohol, and genetic predisposition are the major risk factors for ch

65 Two genetic predispositions are particularly crucial.

66 omplications, introducing the possibility of genetic predisposition as a risk factor.

67 -/-)p53(-/-)Rag2(-/-) mice exhibit a similar genetic predisposition as do H2ax(-/-)p53(-/-) mice to t

68 netic alterations, influenced by a patient's genetic predisposition as well as by environmental influ

69 Confirmation of genetic predisposition, as defined by reproducibility an

70 Although genetic predisposition can play a substantial role, our

71 nd the ubiquitin-binding protein, p62, has a genetic predisposition component in humans and mice.

72 ar evidence that environmental exposures and genetic predisposition contribute to the pathogenesis of

73 ll carcinoma (RCC) have been identified, yet genetic predisposition contributes significantly to this

74 wing researchers to determine how underlying genetic predisposition contributes to human disease.

75 The genetic predisposition defined by the combination of 10

76 We hypothesized that germline genetic predispositions differ between African Americans

77 ates of sleep loss at night and propose that genetic predisposition entails differential cerebral cop

78 se is a multifactorial process that includes genetic predisposition, environmental adjuvant factors,

79 such as diabetes, and/or the interaction of genetic predisposition, environmental insults, and age.

80 ad connections and interdependencies between genetic predisposition, environmental perturbations, reg

81 ns unclear, although studies have implicated genetic predispositions, environmental risk factors, and

82 udies are ideal to investigate the effect of genetic predisposition, epigenetics, and environmental e

83 he pathogenesis is multifactorial, involving genetic predisposition, epithelial barrier defects, dysr

84 Although genetic predisposition establishes susceptibility, rapid

85 t contradict the data obtained on a possible genetic predisposition, even in sporadic or non-heredita

86 ies, identified prognostic markers, assessed genetic predispositions, explored new pharmacological ag

87 of ALL and highlight a possible link between genetic predisposition factors in the pathogenesis of au

88 g will meet the challenge of elucidating the genetic predisposition for common polygenic diseases, es

89 variants in RTEL1 represent a newly defined genetic predisposition for FIP, supporting the importanc

90 of one disease in another probably reflect a genetic predisposition for immune expression that is sha

91 especially when accompanied by a heightened genetic predisposition for response to physical exercise

92 BD patients suggest a differential effect of genetic predisposition for SZ versus BD on the developme

93 on epidemiologic data, there appears to be a genetic predisposition for the development of SUI.

94 irst-degree relatives, possibly representing genetic predisposition for these disorders.

95 enes in a DNA segment on chromosome 1 with a genetic predisposition for this disease.

96 c regions than BALB/c mice, which suggests a genetic predisposition for this histological feature.

97 FD-induced obesity, the hPXR mouse carries a genetic predisposition for type 2 diabetes and thus prov

98 n VR-PAH, suggesting a potentially different genetic predisposition for VR-PAH.

99 nation, including moderating factors such as genetic predisposition, habitual caffeine intake, and ca

100 actors can contribute to these conditions, a genetic predisposition has an important role as well.

101 As the importance of genetic predisposition has been firmly established in th

102 In schizophrenia, genetic predisposition has been linked to chromosome 22q

103 d spots are a common skin aging feature, but genetic predisposition has yet to be thoroughly investig

104 nce that the risk and course of HF depend on genetic predisposition; however, the genetic contributio

105 Risk factors for AF include age, male sex, genetic predisposition, hypertension, diabetes mellitus,

106 Here we studied genetic predisposition in a family with six affected ind

107 his explains a substantial proportion of the genetic predisposition in African- and Hispanic-American

108 Increased understanding of genetic predisposition in atopy and eczema has directed

109 A role for a genetic predisposition in diverticulitis is suggested by

110 tis media susceptibility reflects underlying genetic predisposition in genes like EYA4 that regulate

111 ns of TV watching and physical activity with genetic predisposition in relation to BMI were independe

112 atching, leisure time physical activity, and genetic predisposition in relation to body mass index (B

113 ciation studies have highlighted the role of genetic predisposition in the etiology of colitis and st

114 apped shared chromosomal regions to identify genetic predisposition in the family.

115 be inherited as a single-gene disorder, the genetic predisposition in the majority of affected peopl

116 Specific dietary interventions based on genetic predisposition in this population may lead to mo

117 Thus, there is a genetic predisposition inherent in B-1 development gener

118 elopment of mirror mechanisms are discussed: Genetic predispositions interact with associative learni

119 the intersection and interactions between a genetic predisposition involving the BMPR2 signaling pat

120 and glucocerebrosidase (GBA) have shown that genetic predisposition is another important causal facto

121 Genetic predisposition is common for many of the general

122 Genetic predisposition is increasingly recognized as an

123 Genetic predisposition is recognized as an important fac

124 Genetic predisposition is recognized as an important pat

125 eness is one of the mechanisms through which genetic predisposition leads to weight gain in an enviro

126 Genetic predisposition mainly arises from mutations on t

127 ranscription regulation, suggest that a weak genetic predisposition may contribute to mechanisms caus

128 in women, and those with a prior history or genetic predisposition may particularly benefit.

129 Genetic predisposition may synergistically interact with

130 Patients with genetic predispositions may rarely have disease triggere

131 rrier function is disrupted by, for example, genetic predisposition, mechanical damage, or the enzyma

132 esis that voluntary exercise can prevent the genetic predisposition of melanocortin-4 receptor-associ

133 and addressed two questions, (1) whether the genetic predisposition of nicotine dependence influence

134 We found the genetic predisposition of nicotine dependence was associ

135 We investigated a genetic predisposition of the CAV-1 gene on survival, ac

136 The genetic predisposition of the host to local or systemic

137 robial toxins, environmental insults, or the genetic predisposition of the host.

138 nt patterns depending both on vaccine Ag and genetic predisposition of the vaccinee.

139 associated secretory phenotype, indicating a genetic predisposition of these mice to increased carcin

140 d very little is known about the etiology or genetic predisposition of this condition.

141 The influence of genetic predisposition on nonsyndromic primary rhegmatog

142 mined the role of maternal farm exposure and genetic predisposition on TH17 cell responses to innate

143 nteractions between diet, DNMT-1 levels, and genetic predisposition on the development and severity o

144 An unrecognized genetic predisposition or altered gut permeability causi

145 luenced by diet as an infant, rather than by genetic predispositions or lifestyles and behaviors.

146 er hypermutant cancers arising from primary (genetic predisposition) or secondary MMRD.

147 ated with later AF onset after adjusting for genetic predisposition (P<0.001).

148 Our data suggest that prenatal exposures and genetic predisposition play a role during early TH17 imm

149 there are many modulating factors including genetic predisposition, products of the innate immune sy

150 Our findings indicate that specific genetic predispositions promote the development of coron

151 We could show that the genetic predisposition provided by the NOD background wa

152 also raise the possibility of an impact from genetic predispositions related to oxidative stress and

153 ctly without necessarily going through human genetic predispositions, resulting in inter-specific gen

154 show that superimposition of inflammation on genetic predisposition results in high incidence of pret

155 for association of individual variants and a genetic predisposition score (GPS-17), calculated by sum

156 n scores (GRSs) were constructed: a complete genetic predisposition score including all 50 single nuc

157 le nucleotide polymorphisms (GRSComplete), a genetic predisposition score including BMI-associated si

158 ngle nucleotide polymorphisms (GRSWC), and a genetic predisposition score including the waist-to-hip

159 single nucleotide polymorphisms (GRSBMI), a genetic predisposition score including waist circumferen

160 The genetic predisposition score showed consistent associati

161 A genetic predisposition score was calculated on the basis

162 f CVD comparing the extreme quartiles of the genetic predisposition score.

163 The genetic-predisposition score was calculated on the basis

164 o adjusted for BMI (WHRBMI), the following 4 genetic predisposition scores (GRSs) were constructed: a

165 Genetic predispositions strongly contribute to the devel

166 Genetic predispositions strongly influence disease occur

167 that has happened in historical times and a genetic predisposition that has its origins in our evolu

168 e first platelet function-related CpG-SNP, a genetic predisposition that reinforces PEAR1 enhancer ac

169 ings reflect the clinical association of the genetic predisposition that was recently confirmed in a

170 idence also suggests, apart from traditional genetic predisposition, that epigenetic processes can pe

171 on a number of different factors, including genetic predisposition, the number and releasability of

172 he antecedents of these processes, including genetic predispositions, the harshness of the early envi

173 in analyses of the DeltaWCBMI CONCLUSIONS: A genetic predisposition to a high WC may attenuate the as

174 score for WHR adjusted for BMI, a measure of genetic predisposition to abdominal adiposity, was const

175 These results suggest that genetic predisposition to acrophobia in this genetic iso

176 e earliest brain changes associated with the genetic predisposition to AD.

177 The genetic predisposition to addiction to opioids and other

178 intake of such beverages interacts with the genetic predisposition to adiposity is unknown.

179 ng focus on the interaction between diet and genetic predisposition to adiposity, studies should cons

180 atic.This review presents the evidence for a genetic predisposition to adverse drug reactions, focusi

181 c histone deacetylase (HDAC) isoforms in the genetic predisposition to anxiety and alcoholism is unkn

182 In addition to asbestos exposure, genetic predisposition to asbestos carcinogenesis and to

183 t interactions and that in the presence of a genetic predisposition to ASD, diet can make a large dif

184 The mechanism is unknown, and genetic predisposition to asparaginase-induced pancreati

185 There is strong evidence for a genetic predisposition to autism and an intense interest

186 These data indicate that in the absence of genetic predisposition to autoimmunity, loss of endogeno

187 lustrate that organ damage can occur without genetic predisposition to autoimmunity.

188 Many of the afflicted have a genetic predisposition to become obese.

189 ive control of emotion are implicated in the genetic predisposition to bipolar disorder, with aberran

190 Pathways involved in the genetic predisposition to BP include hormonal regulation

191 e and begin to unravel common aspects in the genetic predisposition to bronchopulmonary dysplasia, br

192 Therefore, a genetic predisposition to build strong memories could le

193 type, oxidation of phospholipids, Lp(a), and genetic predisposition to CAD and cardiovascular events.

194 ion and outcomes of population screening for genetic predisposition to cancer in other populations.

195 gen-based immune prevention for those with a genetic predisposition to cancer.

196 rates that SPCA1 haploinsufficiency causes a genetic predisposition to cancer.

197 We adopted the HLA-B *1502 genetic predisposition to carbamazepine (CBZ)-induced St

198 Evidence suggests a genetic predisposition to chronic beryllium disease (CBD

199 Some evidence suggests a genetic predisposition to chronic venous disease from ge

200 Much of the genetic predisposition to colorectal cancer (CRC) in hum

201 BACKGROUND & AIMS: Although there is a genetic predisposition to colorectal cancer (CRC), few o

202 beginning to understand the contribution of genetic predisposition to complex liver disease through

203 The importance of genetic predisposition to coronary artery disease and my

204 DNA-based tests for assessment of genetic predisposition to coronary heart disease need to

205 nisms that cause AF in patients, including a genetic predisposition to develop AF.

206 in vivo evidence of an underlying germ-line genetic predisposition to developing this disorder.

207 The authors hypothesized that genetic predisposition to diabetes complications would b

208 nstrating the role of beta cell fragility in genetic predisposition to diabetes.

209 the human AM gene have been associated with genetic predisposition to diabetic nephropathy and prote

210 ariability is unlikely to explain the entire genetic predisposition to disease.

211 in a few cases, have been associated with a genetic predisposition to disease.

212 mportance of infectious stimuli in modifying genetic predisposition to disease.Insight into the genet

213 activation are exacerbated in offspring with genetic predisposition to dopaminergic abnormalities ind

214 ch the molecular complexities underlying the genetic predisposition to drink alcohol.

215 aimed to examine the association between the genetic predisposition to dyslipdemia and type 2 diabete

216 Genetic predisposition to dyslipidemia was estimated by

217 Genetic predisposition to elevated LDL-C was associated

218 Genetic predisposition to elevated triglyceride levels w

219 The authors sought to evaluate whether a genetic predisposition to elevations in plasma lipids is

220 genetic risk scores (GRSs), a measure of the genetic predisposition to elevations in plasma lipids, c

221 A genetic predisposition to enhanced nitric oxide signalin

222 Here, we seek to understand the impact of a genetic predisposition to enhanced nitric oxide signalin

223 A genetic predisposition to enhanced nitric oxide signalin

224 light potentially novel contributors for the genetic predisposition to familial WM and indicate that

225 A genetic predisposition to fibrosis may account for much

226 We aimed to examine the association between genetic predisposition to high blood pressure and risk o

227 Our data indicate that genetic predisposition to high blood pressure is associa

228 A genetic predisposition to high BMI as well as a genetic

229 etic predisposition to high BMI as well as a genetic predisposition to high BMI, WC, and WHRBMI combi

230 e advantages and disadvantages of disclosing genetic predisposition to high BP for risk stratificatio

231 ere was considerable homogeneity in terms of genetic predisposition to high endurance potential, with

232 obesogenic environment, to evaluate whether genetic predisposition to higher BMI has a larger magnit

233 The objective was to examine whether genetic predisposition to higher body mass index (BMI),

234 A genetic predisposition to higher serum calcium levels wa

235 omising AUD treatment for individuals with a genetic predisposition to higher synaptic DA tone.

236 A genetic predisposition to higher waist-to-hip ratio adju

237 unknown whether this variability reflects a genetic predisposition to hypothalamic amenorrhea.

238 Genetic predisposition to increased blood cholesterol an

239 Genetic predisposition to increased WHR adjusted for BMI

240 t several of these advances, with a focus on genetic predisposition to IPF and how genetic changes, w

241 Genetic predisposition to IPF is evident from its famili

242 lation in healthy volunteers account for the genetic predisposition to ischemic stroke and examined t

243 Genetic predisposition to life-threatening cardiac arrhy

244 OE4 allele represents the first demonstrated genetic predisposition to longer duration of delirium in

245 fracture risk only in women with the lowest genetic predisposition to low BMD.

246 In conclusion, genetic predisposition to low HDL cholesterol or high tr

247 The genetic predisposition to many autoimmune diseases is in

248 There is a genetic predisposition to many childhood parasomnias.

249 Given the emerging evidence for a genetic predisposition to MDB formation and NASH develop

250 U gene have been shown to be associated with genetic predisposition to medulloblastoma, mainly in fam

251 Advances in understanding the genetic predisposition to migraine, and the discovery of

252 The genetic predisposition to multiple sclerosis (MS) is mos

253 this study support the role of HTR2A in the genetic predisposition to musculoskeletal pain.

254 Three of 47 individuals with presumed genetic predisposition to neuroblastoma showed a germlin

255 Little is known about the genetic predisposition to neurodegenerative properties o

256 We assessed the association between genetic predisposition to obesity and CCA IMT.

257 Genetic predisposition to obesity may have greater effec

258 habitual sleep duration could ameliorate the genetic predisposition to obesity via a favorable dietar

259 mma (PPARgamma) genotype as a measure of the genetic predisposition to obesity were investigated.

260 Independent of a genetic predisposition to obesity, maternal intake of DH

261 Furthermore, a relation could depend on genetic predisposition to obesity.

262 y, and this association may be modified by a genetic predisposition to obesity.

263 , especially among individuals having a high genetic predisposition to obesity.

264 These findings provide insights into genetic predisposition to oxidative stress and the relat

265 oding RNAs, such as microRNAs (miRNAs), to a genetic predisposition to pathological conditions has re

266 is trait will provide a basis to dissect the genetic predisposition to PBC.

267 types outside the brain are involved in the genetic predisposition to PD.

268 fects the miR expression, contributes to the genetic predisposition to PTC, and plays a role in the t

269 A genetic predisposition to RA, such as HLA-DR4 positivity

270 These data suggest that a genetic predisposition to raised plasma isoleucine level

271 Genetic studies find a genetic predisposition to ROP-linking genes in the Wnt p

272 uding NRG1 and ErbB4 have been implicated in genetic predisposition to schizophrenia.

273 To understand the genetic predisposition to selective immunoglobulin A def

274 A genetic predisposition to Staphylococcus aureus bacterem

275 Genetic predisposition to statin myopathy is a rapidly e

276 Genetic predisposition to systemic lupus erythematosus r

277 k factor for autoimmunity in children with a genetic predisposition to T1D.

278 only 19% in KK/HIJ mice, indicating a strong genetic predisposition to the development of specific CR

279 Although there is evidence of genetic predisposition to the disease, most of the genet

280 We investigated genetic predisposition to the response to steroid treatm

281 This suggests an underlying constitutional genetic predisposition to these somatic changes which co

282 A genetic predisposition to thoracic aortic aneurysm has b

283 Genetic predisposition to thrombosis is still poorly und

284 According to a common hypothesis the genetic predisposition to thyroid cancer is highly heter

285 To further dissect the genetic predisposition to treatment-refractory Lyme arth

286 Finally, we demonstrate that genetic predisposition to type 2 diabetes associates wit

287 xamined the interactions between a molecular genetic predisposition to various aspects of obesity and

288 e association studies (GWAS) are identifying genetic predisposition to various diseases.

289 In SSc pedigrees, genetic predisposition to vasculopathy is the most frequ

290 vides new information on the determinants of genetic predisposition to whipworm infection.

291 A variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disord

292 Many patients have genetic predispositions to both forms of diabetes, resul

293 is-regulatory elements may be a paradigm for genetic predispositions to common disease.

294 Identification of genetic predispositions to IA could have important impli

295 Our findings suggest that genetic predispositions to obesity may partly exert thei

296 ity to examine the relative contributions of genetic predisposition versus rearing environment in gen

297 Genetic predisposition was assessed using heritability a

298 amiliality studies show evidence of a strong genetic predisposition; whereas initial pedigree analyse

299 Our findings suggest a novel model of RA genetic predisposition, which involves cell-membrane rec

300 Furthermore, serum lipids share a genetic predisposition with both calcification in the ao