ライフサイエンスコーパス: genetic risk factor

1 heir use is human (h)-APOE4, the greatest AD genetic risk factor.

2 DNA that dictates the expression of a given genetic risk factor.

3 nnot be attributed to major known IBD and RA genetic risk factors.

4 nders, a portion arises from common familial/genetic risk factors.

5 opmental disorders that are thought to share genetic risk factors.

6 g findings as well as strategies for mapping genetic risk factors.

7 y lipoproteins, independent of age, sex, and genetic risk factors.

8 e predisposition of certain breeds indicates genetic risk factors.

9 hat schizophrenia and bipolar disorder share genetic risk factors.

10 l cardiomyocyte replication to determine the genetic risk factors.

11 rkinson's disease (PD) has a number of known genetic risk factors.

12 onset RA and childhood-onset RA share common genetic risk factors.

13 It is unclear whether this holds for genetic risk factors.

14 DGFRA gene, but there are no known inherited genetic risk factors.

15 ate AMD that was independent of systemic and genetic risk factors.

16 n from them, one can improve power to detect genetic risk factors.

17 independent of widely accepted clinical and genetic risk factors.

18 ts will be required for securely identifying genetic risk factors.

19 body production and were not enriched in the genetic risk factors.

20 sociated clinical features and outcomes, and genetic risk factors.

21 complex disease with both environmental and genetic risk factors.

22 ome is then determined by R1210C-independent genetic risk factors.

23 sk factors such as age, gender, smoking, and genetic risk factors.

24 se-control group of 213 patients to identify genetic risk factors.

25 The effect of known genetic risk factors (97 single-nucleotide polymorphisms

26 This review explores a newly described major genetic risk factor, a mutation in the skin matrix prote

27 As disrupted-in-schizophrenia 1 (DISC1) is a genetic risk factor across a spectrum of psychiatric dis

28 prominent in males than in females, with new genetic risk factors affecting irritability in early and

29 ry arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology

30 performance, and thus, the combination of a genetic risk factor and altered modulation may provide i

31 the human ortholog of PBP1, are a known ALS genetic risk factor and ataxin 2 is a stress granule com

32 rs12487066 variant in the interactions of a genetic risk factor and IFN function during viral infect

33 he study of the functional consequences of a genetic risk factor and, eventually, its contribution to

34 ecrease in percent DR3/4 suggest a change in genetic risk factors and environmental determinants of t

35 ogy of LDD, implicating an interplay between genetic risk factors and miRNA.

36 to increase, with the aim of discovering new genetic risk factors and obtaining insight into the dise

37 enabling the functional validation of known genetic risk factors and potentially pathogenic alleles

38 iations between demographic, behavioral, and genetic risk factors and the 2 outcomes were analyzed us

39 Discovering new genetic risk factors and understanding the mechanisms wh

40 gender dependent and highly sensitive to the genetic risk factor APOE4 Our findings highlight the spe

41 uals who are negative for the established AD genetic risk factor, apolipoprotein E (APOE) varepsilon4

42 Environmental and genetic risk factors are implicated in the pathogenesis

43 rse can be distinguished, for which specific genetic risk factors are known.

44 However, the contributing genetic risk factors are poorly understood.

45 Most of the genetic risk factors are unknown.

46 patients and healthy controls have unearthed genetic risk factors associated with a range of neurolog

47 s review summarizes the current knowledge on genetic risk factors associated with LOAD risk in Caribb

48 nabled the discovery of more than 50 non-HLA genetic risk factors associated with MS.

49 an animal model for multiple sclerosis, and genetic risk factors associated with multiple sclerosis

50 AD; in which it is the single most important genetic risk factor), atherosclerotic cardiovascular dis

51 izophrenia risk, with substantial overlap in genetic risk factors between multiply affected families

52 In this study, we sought to identify the PA genetic risk factors by focusing on causative mutations

53 This study suggests that the AD genetic risk factor CALM modulates autophagy, and this m

54 hat this mutation, in combination with other genetic risk factors, can lead to disease through sustai

55 of common and rare functionally significant genetic risk factors causing disease.

56 prostate are modified by specific, intrinsic genetic risk factors, causing some men to respond negati

57 Although the data suggest genetic risk factors common to both SLI and ASD, there a

58 Genetic risk factors contribute to adverse outcome of he

59 ral network analysis both indicated that the genetic risk factors contributed positively to the predi

60 DD can successfully lead to the discovery of genetic risk factor despite reduced sample size.

61 Moreover, new sets of genetic risk factors emerged at ages 13 to 14, 16 to 17,

62 ajor bottleneck in the identification of its genetic risk factors, especially in genome-wide associat

63 Our findings suggest that psychiatric genetic risk factors expressed in astrocytes could affec

64 Disrupted-in-Schizophrenia-1 (DISC1) is a genetic risk factor for a wide range of major mental dis

65 Apolipoprotein (apo) E4 is a major genetic risk factor for a wide spectrum of inflammatory

66 The most prevalent genetic risk factor for AD is the epsilon4 allele of apo

67 Coupled with a significant genetic risk factor for AD, changes in modulation may pr

68 viously demonstrated that the most prevalent genetic risk factor for AD, the ApoE4 allele, is correla

69 rning and memory in humans, and is the major genetic risk factor for AD.

70 tations, and apolipoprotein E, the strongest genetic risk factor for AD.

71 occurring genotype of APOE, is the greatest genetic risk factor for AD; increasing risk up to 12-fol

72 Our results implicate BDNF as a genetic risk factor for ADHD, potentially by virtue of i

73 hism has been widely regarded as a potential genetic risk factor for affective disorders.

74 encoding apolipoprotein E (apoE) is a strong genetic risk factor for aging-related cognitive decline

75 important role for the CHRNA5/3 region as a genetic risk factor for airflow obstruction that may be

76 he immune response of microglia, is a strong genetic risk factor for Alzheimer disease (AD) and possi

77 APOE varepsilon4, the most significant genetic risk factor for Alzheimer disease (AD), may mask

78 lon4 allele is a common and well-established genetic risk factor for Alzheimer disease (AD).

79 such as hypertension, in combination with a genetic risk factor for Alzheimer disease (apolipoprotei

80 oprotein E (APOE) epsilon4 allele is a major genetic risk factor for Alzheimer disease and dementia.

81 APOE4 is a major genetic risk factor for Alzheimer disease and is associa

82 ApoE4 constitutes the most important genetic risk factor for Alzheimer's disease (AD), ApoE3

83 was designed to investigate the effect of a genetic risk factor for Alzheimer's disease (AD), Apolip

84 Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD), but th

85 polipoprotein E4 (apoE4), the most prevalent genetic risk factor for Alzheimer's disease (AD), is les

86 Apolipoprotein E (APOE) epsilon4 is a major genetic risk factor for Alzheimer's disease (AD), yet th

87 Apolipoprotein E4 (apoE4) is the major genetic risk factor for Alzheimer's disease (AD).

88 PICALM is a highly validated genetic risk factor for Alzheimer's disease (AD).

89 polipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer's disease (AD).

90 in E (APOE) epsilon4 allele is the strongest genetic risk factor for Alzheimer's disease (AD).

91 lipoprotein E4 (ApoE4) gene is the strongest genetic risk factor for Alzheimer's disease (AD).

92 ic studies identified ApoE4 as the strongest genetic risk factor for Alzheimer's disease (AD).

93 Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease and is assoc

94 APOE4 is a major genetic risk factor for Alzheimer's disease and is assoc

95 CD2-associated protein (CD2AP) is a leading genetic risk factor for Alzheimer's disease, but little

96 ation to age and the presence of the APOE E4 genetic risk factor for Alzheimer's disease.

97 Apolipoprotein E4 (apoE4) is the strongest genetic risk factor for Alzheimer's disease.

98 is (IV) and represent the major predisposing genetic risk factor for atopic dermatitis (AD).

99 disorder of keratinization-and also a strong genetic risk factor for atopic eczema, marked a signific

100 ding protein at glutamatergic synapses, is a genetic risk factor for autism.

101 is a highly prevalent (around 20% of people) genetic risk factor for cardiovascular disease and calci

102 r, they contribute to underscore a potential genetic risk factor for cardiovascular diseases, includi

103 identify a common, functionally significant genetic risk factor for Caucasian heart failure.

104 chromosome 17q21 locus, the strongest known genetic risk factor for childhood asthma.

105 mulated that Lp(a) is a causal, independent, genetic risk factor for CVD.

106 on 4 (apoE epsilon4) allele is known to be a genetic risk factor for developing AD.

107 mouse model of the 22q11.2 microdeletion, a genetic risk factor for developing several neuropsychiat

108 poprotein E4 (ApoE4) allele is the strongest genetic risk factor for developing sporadic Alzheimer's

109 oding glucocerebrosidase, represent a common genetic risk factor for developing the synucleinopathies

110 Deletions on chromosome 22q11.2 are a strong genetic risk factor for development of schizophrenia and

111 The results show that the APOE is a strong genetic risk factor for DLB, confirming previous finding

112 est that 22q11.2 deletions represent a novel genetic risk factor for early-onset PD with variable neu

113 also been found to be an important class of genetic risk factor for epilepsy.

114 ce motif that is the single most significant genetic risk factor for erosive rheumatoid arthritis, ac

115 acellular sorting receptor SORLA, is a major genetic risk factor for familial and sporadic forms of A

116 nsufficiency of progranulin (GRN) is a major genetic risk factor for frontotemporal lobar degeneratio

117 T allele may be regarded as a genetic risk factor for HCV-related carcinogenesis, post

118 Apolipoprotein E4 (apoE4), the major genetic risk factor for late onset Alzheimer disease, as

119 olipoprotein E (apoE) is the strongest known genetic risk factor for late onset Alzheimer's disease (

120 4) genotype has been identified as the major genetic risk factor for late onset Alzheimer's disease (

121 The most significant genetic risk factor for late onset Alzheimer's disease i

122 E (APOE) epsilon4 gene allele, the strongest genetic risk factor for late-onset AD.

123 polipoprotein E (apoE) gene is the strongest genetic risk factor for late-onset AD.

124 protein E4 (APOE4) genotype is the strongest genetic risk factor for late-onset Alzheimer disease and

125 apolipoprotein E (APOE) 4 allele is a major genetic risk factor for late-onset Alzheimer disease, it

126 polipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer disease.

127 APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease.

128 erin (CLU) gene is the third strongest known genetic risk factor for late-onset Alzheimer's disease (

129 lipoprotein epsilon4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease (

130 e of apolipoprotein E (APOE) is the dominant genetic risk factor for late-onset Alzheimer's disease (

131 As the epsilon4 allele of APOE is the major genetic risk factor for late-onset Alzheimer's disease,

132 in E (APOE)-epsilon4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer's

133 -In-Schizophrenia-1 (DISC1), a well-accepted genetic risk factor for mental illness, display abnormal

134 intronic variant in ANKRD55, rs6859219, is a genetic risk factor for multiple sclerosis, but the biol

135 eptor subunit gene (CHRNA5) is the strongest genetic risk factor for nicotine dependence in European

136 F2) loss-of-function variant rs58542926 is a genetic risk factor for nonalcoholic fatty liver disease

137 Because GBA1 mutations are the most common genetic risk factor for Parkinson disease, dopaminergic

138 er Gaucher's disease (GD), are the strongest genetic risk factor for Parkinson's disease (PD) known t

139 encodes GCase have been uncovered as a major genetic risk factor for Parkinson's disease (PD).

140 for Gaucher disease (GD) are the most common genetic risk factor for Parkinson's disease (PD).

141 ions in the gene GBA are the most widespread genetic risk factor for parkinsonism identified to date.

142 h cause Gaucher disease, are the most common genetic risk factor for PD, underscoring the importance

143 nscription factor gene NPAS3 is a replicated genetic risk factor for psychiatric disorders.

144 MEIS1 was confirmed as the strongest genetic risk factor for restless legs syndrome (odds rat

145 Variation at HLA_DQA1-DQB1 is the major genetic risk factor for RHD in Aboriginal Australians st

146 of a model of the 22q11.2 deletion, a strong genetic risk factor for schizophrenia (SCZ).

147 ations in GBA1 are now the most common known genetic risk factor for several Lewy body disorders, and

148 Apolipoprotein E4 (ApoE4) is a major genetic risk factor for several neurodegenerative disord

149 ther partial C4 deficiency is an independent genetic risk factor for SLE, we investigated C4 CNV in t

150 polipoprotein E4 (apoE4) allele is the major genetic risk factor for sporadic Alzheimer disease (AD)

151 The APOE4 allele is the strongest genetic risk factor for sporadic Alzheimer disease (AD).

152 otein E (APOE) varepsilon4 allele is a major genetic risk factor for sporadic Alzheimer's disease (AD

153 rotein E epsilon4 gene is the most important genetic risk factor for sporadic Alzheimer's disease, bu

154 expressing the human APOE4 allele, the main genetic risk factor for sporadic MCI/AD, display impaire

155 SORLA has been identified as a genetic risk factor for sporadic, but recently also for

156 ApoE4 is the major genetic risk factor for the age-dependent form of AD, wh

157 ilaggrin gene are the most significant known genetic risk factor for the development of atopic dermat

158 e deficient in Gaucher disease, are a common genetic risk factor for the development of Parkinson dis

159 Numerically, the most important genetic risk factor for the development of Parkinson dis

160 in Gaucher's disease (GD) and are the major genetic risk factor for the development of Parkinson's d

161 11.2 locus have been established as a strong genetic risk factor for the development of schizophrenia

162 effect on brain physiology and may present a genetic risk factor for the development of seizures and

163 E, whose epsilon4 isoform is the most common genetic risk factor for the disease.

164 d in schizophrenia 1 (DISC1) is an important genetic risk factor for these disorders.

165 se (LYP) and is the second strongest non-HLA genetic risk factor for type 1 diabetes.

166 16p11.2 duplication represents a significant genetic risk factor for typical and atypical RE.

167 Factor V Leiden (F5(L) ) is a common genetic risk factor for venous thromboembolism in humans

168 These data link three genetic risk factors for AD and reveal a possible mechan

169 t studies showing the differential effect of genetic risk factors for AD on brain functional connecti

170 However, the recent identification of genetic risk factors for AD promises to provide new insi

171 the hypothesis that there is a link between genetic risk factors for AD, cellular metabolic stress,

172 the recent identification of immune-related genetic risk factors for AD, including coding variants i

173 We sought to identify novel genetic risk factors for AD.

174 should yield unprecedented insights into the genetic risk factors for aneuploidy.

175 umber variants (CNVs) have emerged as robust genetic risk factors for ASD, but not all CNV carriers e

176 Here we discuss the unique and shared genetic risk factors for atopic disorders in the context

177 Genetic risk factors for autism spectrum disorder (ASD)

178 Almost all genetic risk factors for autism spectrum disorders (ASDs

179 icted to target multiple genes implicated as genetic risk factors for BD, are increased in postmortem

180 To identify genetic risk factors for breast cancer in women of Afric

181 igned to efficiently study environmental and genetic risk factors for breast cancer.

182 isk, at present no well-established specific genetic risk factors for CAD have been elucidated.

183 We identify three novel genetic risk factors for candidaemia, which we subsequen

184 domized controlled trial of 230 infants with genetic risk factors for celiac disease, we did not find

185 year prospective study of 1339 children with genetic risk factors for celiac disease, we found the cu

186 The genetic risk factors for chronic obstructive pulmonary d

187 Identifying genetic risk factors for CIAG could enable safer and mor

188 ciation studies (GWASs) have identified many genetic risk factors for CKD.

189 tory factor 6 (Irf6) have been identified as genetic risk factors for cleft palate, little is known a

190 .2 deletion syndrome, one of the most common genetic risk factors for cognitive dysfunction and schiz

191 th chronic pancreatitis (CP) frequently have genetic risk factors for disease.

192 s allows the dissection of moderate and mild genetic risk factors for disease.

193 1 diabetes to determine whether sex-specific genetic risk factors for ESRD exist.

194 prior genotype data, to identify additional genetic risk factors for gallstone disease.

195 This preliminary analysis of inherited genetic risk factors for GIST offers some clues about th

196 We review the genetic risk factors for late-onset Alzheimer's disease

197 NDE1, and NDEL1 have each been implicated as genetic risk factors for major mental illness.

198 t a neural system in which environmental and genetic risk factors for mental illness may converge.

199 pared with Parkinson disease (PD), potential genetic risk factors for mild parkinsonian signs have be

200 were larger in the cohort bearing the major genetic risk factors for MS (female sex and HLA risk hap

201 Few genetic risk factors for neural tube defects are known i

202 uggest that contrary to the prevailing view, genetic risk factors for neurodegenerative diseases at t

203 Here, we perform the first evaluation of genetic risk factors for osteonecrosis in children <10 y

204 Among the known genetic risk factors for Parkinson disease, mutations in

205 roidal neovascularization (CNV) subtype, the genetic risk factors for PCV are relatively unknown.

206 Several genetic risk factors for POAG and optic nerve features h

207 genome-wide association study identified new genetic risk factors for progressive supranuclear palsy

208 To discern differences in genetic risk factors for PsA and cutaneous-only psoriasi

209 Several known genetic risk factors for psychiatric disease are related

210 The identification of genetic risk factors for PTSD may provide important insi

211 nit APH1B have been previously implicated as genetic risk factors for schizophrenia and schizophrenia

212 lay an acknowledged role in the strongest of genetic risk factors for schizophrenia, 22q11.2 deletion

213 oking behavior may facilitate the search for genetic risk factors for schizophrenia.

214 R620W variant of PTPN22 is one of the major genetic risk factors for several autoimmune disorders in

215 association studies are identifying multiple genetic risk factors for several diseases, but the funct

216 ncy of complement C4 is one of the strongest genetic risk factors for SLE, partial C4 deficiency stat

217 tromer coat complex, have been implicated as genetic risk factors for sporadic and autosomal dominant

218 The genetic risk factors for susceptibility to chronic obstr

219 in the HLA region remain the most important genetic risk factors for T1D, other non-HLA genetic fact

220 tion studies have increased our knowledge of genetic risk factors for the IIMs.

221 on patients >/=10 years of age, leaving the genetic risk factors for the larger group of children <1

222 t to identify clinical, pharmacokinetic, and genetic risk factors for these MTX-related toxicities du

223 ssociation study with the aim of identifying genetic risk factors for this disorder.

224 ility in India and Brazil, suggesting shared genetic risk factors for visceral leishmaniasis that cro

225 To identify new genetic risk factors for Vogt-Koyanagi-Harada (VKH) synd

226 Further studies of environmental and genetic risk factors for VTE are needed to determine whi

227 n conclusion, our study reveals novel common genetic risk factors for VTE, stroke and CAD and provide

228 tates cross-study analysis to discover novel genetic risk factors, gene-disease associations, potenti

229 f autophagy related 16-like 1 (ATG16L1) as a genetic risk factor has exposed the critical role of aut

230 Manipulation of the mouse genome to study genetic risk factors has largely proved informative, but

231 However, as only a handful of genetic risk factors have been investigated beyond initi

232 (venous thromboembolism, VTE), biomarkers or genetic risk factors have not been identified.

233 To identify further genetic risk factors, here we assess the role of de novo

234 cancer deaths, yet there have been few known genetic risk factors identified, the best known of which

235 A study of the genetic risk factors identifying patients in whom aspara

236 Disrupted-In-Schizophrenia 1 (DISC1), a genetic risk factor implicated in major mental disorders

237 NPAS3 has been established as a robust genetic risk factor in major mental illness.

238 gnition receptor that is the strongest known genetic risk factor in the pathogenesis of Crohn disease

239 s in related individuals can account for non-genetic risk factors in an integrated manner.

240 o examined in population studies to identify genetic risk factors in complex traits and to predict ev

241 Genetic risk factors in interaction with trauma exposure

242 he use of childhood clinical factors and the genetic risk factors in predicting adulthood obesity usi

243 To elucidate the possible role of genetic risk factors in such findings, it is necessary t

244 To search for genetic risk factors in SUDEP cases, we performed an exo

245 While the role of genetic risk factors in the etiology of uveal melanoma (

246 enesis have been indicated by the identified genetic risk factors, including type I interferon signal

247 he signal on 2p25 and to identify additional genetic risk factors increasing susceptibility for attem

248 hat of polygenicity, meaning that many small genetic risk factors influence risk in the population an

249 The strongest genetic risk factor influencing susceptibility to late-o

250 f differences in clinical, socioeconomic, or genetic risk factors is unknown.

251 f depression including its environmental and genetic risk factors, its association with the acute pha

252 to be a major hindrance to the discovery of genetic risk factors, leading to numerous attempts to st

253 fferences in how the striatum is impacted by genetic risk factors linked to neurodevelopmental disord

254 nue to suffer from ADHD during adulthood and genetic risk factors may play an essential role in the p

255 PLG is the third replicated shared genetic risk factor of atherosclerosis and periodontitis

256 BIN1 is a genetic risk factor of late-onset Alzheimer disease (AD)

257 The APOEepsilon4 allele is the major genetic risk factor of sporadic Alzheimer's disease (AD)

258 Genetic risk factors of CeAD are still poorly understood

259 matory bowel disease epithelium, and several genetic risk factors of Crohn's disease affect Paneth ce

260 represents progress toward understanding the genetic risk factors of posttransplantation outcomes in

261 Genetic risk factors often localize to noncoding regions

262 ility loci and show that CBD and PSP share a genetic risk factor other than MAPT at 3p22 MOBP (myelin

263 be 40% to 60% inherited, but until recently genetic risk factors predisposing to CAD have been elusi

264 quantitative traits may effectively identify genetic risk factors predisposing to the complex disease

265 others of neonatal lupus children accumulate genetic risk factors preferentially from the neonatal lu

266 lopment of IPF; however, mechanisms by which genetic risk factors promote IPF remain unclear.

267 lained by shared familial (environmental and genetic) risk factors rather than by the intrauterine en

268 rome strongly influenced by a diverse set of genetic risk factors reflecting a specific liability to

269 ce Taken together, our findings confirm that genetic risk factors related to the presence of GA are n

270 explain disease heritability, and additional genetic risk factors remain to be discovered.

271 hether HCC and psychological variables share genetic risk factors remains unclear.

272 f musculoskeletal disorders, with a focus on genetic risk factors, since these are the most stable ac

273 -induced depression and establish associated genetic risk factors, single nucleotide polymorphisms in

274 f EM was greater than the best validated non-genetic risk factor, smoking.

275 for the A1AT Z-allele with environmental or genetic risk factors such as steatosis or heterozygosity

276 the precise nature of which is specified by genetic risk factors, such as HLA alleles.

277 lity led to the identification of a specific genetic risk factor that approached genome-wide signific

278 in this high-risk group is attributable to a genetic risk factor that partitions with ancestry.

279 me as an interface between environmental and genetic risk factors that are associated with ASD.

280 provides evidence for both shared and unique genetic risk factors that are associated with iron-relat

281 There is strong interest in identifying genetic risk factors that can help to elucidate the path

282 Identification of the genetic risk factors that contribute to geographic atrop

283 genetically complex traits, and the specific genetic risk factors that lead to IgE dysregulation and

284 We sought to ascertain the genetic risk factors that lead to IgE dysregulation.

285 tification of cultural, epidemiological, and genetic risk factors that predispose women of African an

286 udy of inherited forms of early-onset AD and genetic risk factors that provide insights about molecul

287 load are linked to disease progression, but genetic risk factors that regulate oncogene abundance an

288 Despite recent discoveries of new genetic risk factors, the majority of risk for coronary

289 siology, including the role of serotonin and genetic risk factors; the effects of SSRIs on pulmonary

290 We aimed to identify further shared genetic risk factors to better understand conjoint disea

291 ization of molecular mechanisms that connect genetic risk factors to initiation and evolution of dise

292 contribution of clinical, pathological, and genetic risk factors to transformation.

293 of clinical, environmental, demographic, and genetic risk factors was explored in regression models,

294 To identify additional genetic risk factors, we assessed the role of de novo mu

295 ociated variant P2X7R-Gln460Arg represents a genetic risk factor, which is potentially able to convey

296 We find that most diseases are dominated by genetic risk factors, while environmental influences pre

297 anistically link an immunologically relevant genetic risk factor with a functional feature of TH cell

298 terization, we established p.G411S as a rare genetic risk factor with a relatively large effect size

299 a polygenic disorder that shares substantial genetic risk factors with major depressive disorder (MDD

300 ation studies of asthma have implicated many genetic risk factors, with well-replicated associations