ライフサイエンスコーパス: genetic study

1 tly European ancestry in the DiscovEHR human genetics study.

2 ry sample of 3,494 individuals recruited for genetic studies.

3 application of the method to a wide range of genetic studies.

4 infections and can be used for retrospective genetic studies.

5 features, and is becoming popular in imaging genetic studies.

6 sensitivity and rapidly purify LP cells for genetic studies.

7 een challenged by recent clinical trials and genetic studies.

8 ent was assessed through pharmacological and genetic studies.

9 play an important part in stratification for genetic studies.

10 ry sample of 3,494 individuals recruited for genetic studies.

11 pathogenic hypotheses that have emerged from genetic studies.

12 cological methods has been refuted in recent genetic studies.

13 he lack of short-lived vertebrate models for genetic studies.

14 referring to the fruitful outcomes of recent genetic studies.

15 henotypes that remains largely unexplored in genetic studies.

16 Estimation of heritability is fundamental in genetic studies.

17 fier Gene Study, and Canadian Consortium for Genetic Studies.

18 ications for disease control, management and genetic studies.

19 icates, making it ideal for loss-of-function genetic studies.

20 an transmit genetic information, restricting genetic studies.

21 mples are a common source of DNA in wildlife genetic studies.

22 s aged 4 to 97 years, as a prelude to future genetic studies.

23 e a viable source for conducting large-scale genetic studies.

24 inclusion of patients in clinical trials and genetics studies.

25 se insects, opening an avenue for functional genetics studies.

26 ithms have been proposed and used in imaging genetics studies.

27 ion of these rich sources of information for genetics studies.

28 for prioritizing pathogenic STRs in medical genetics studies.

29 Human genetic studies and analyses of knockout mice have revea

30 ray with uniform genome coverage can advance genetic studies and breeding applications.

31 detect polymorphisms in sainfoin for future genetic studies and breeding programs.

32 nd open avenues for facilitating common carp genetic studies and breeding.

33 tified could be fruitfully employed for both genetic studies and breeding.

34 ions that were detected in large-scale human genetic studies and cancer tissues, all of which occur c

35 transcriptional activators are key for many genetic studies and comprise over 90% of mouse models cr

36 It opens a valuable avenue for future genetic studies and human disease diagnosis, including p

37 ans to produce tailored CRC mouse models for genetic studies and pre-clinical investigation.

38 n aids the correct interpretation of in vivo genetic studies and the development of in vitro protocol

39 Orinoco river basins, yet few resources for genetic studies and the genetic improvement of tambaqui

40 Genetic studies and transcriptional profiling experiment

41 eflect different causes has implications for genetic studies and treatment of ADHD.

42 Molecular genetic studies and twin studies have confirmed importan

43 developed and shown to be robust for use in genetic studies and with potential for developing early

44 A viral genetic study and a BiFC assay demonstrated that interac

45 of validating findings from high-throughput genetics studies and call for large collaborative resear

46 tly improve the accuracy of loss-of-function genetics studies and facilitates the generation of compa

47 ds, (ii) power calculations for multivariate genetic studies, and (iii) generating data for testing a

48 Therefore, genetic studies are needed to gain insights into genotyp

49 entifying phenotypes suitable for population genetic studies as well as complications due to multiple

50 d as a relevant biological variable in human genetic studies as well.

51 ed single-cell electrical, morphological and genetic studies at unparalleled resolution.

52 Comparative functional genetic studies between angiosperms and bryophytes can d

53 We addressed this question in a parallel genetic study between the closely related species Arabid

54 ASD pathogenesis have been proposed based on genetic studies, brain pathology and imaging, but a majo

55 earning) that enhance the quality of imaging genetic studies but also introduce new challenges.

56 liary proteins are used to validate research genetic studies, but diagnostic utility in this disease

57 l means of characterizing phenotypic MetS in genetic studies by minimizing racial differences.

58 Genetic studies can also examine off-target effects and

59 application of insight from human population genetic studies can enhance RBC production from stem cel

60 Genetic studies can identify novel therapeutic targets f

61 Cross-ethnic genetic studies can leverage power from differences in d

62 We conclude that imaging genetic studies can provide important insights into the

63 Our study illustrates how population-based genetic studies can provide key insights into poorly und

64 the UMOD paradigm to describe how population genetic studies can yield insight into the pathogenesis

65 Genetic studies confirmed that this mechanism couples Cs

66 Pharmacological and genetic studies confirmed the role of this enzyme as a r

67 The plethora of detailed molecular and genetic studies coupling the structure of antigen-antibo

68 RE has become an integral part of population genetic studies covering a broad spectrum of taxa includ

69 d ancestry is an important component of many genetic studies; current prediction tools accurately est

70 lly to cable formation has been unclear, but genetic studies demonstrate that Tpm1 plays a more impor

71 Mouse genetic studies demonstrated that interferon (IFN)-alpha

72 ent insights from quantitative and molecular genetic studies demonstrating considerable pleiotropy in

73 In light of genetic studies demonstrating the attenuated virulence o

74 Furthermore, we discuss how new genetic study designs are starting to explain inter-indi

75 The discoveries from CHD genetic studies draw attention to biological pathways th

76 f the common carp have made its breeding and genetic studies extremely difficult.

77 Prior genetic studies focused on traits defined using the apne

78 Complementary genetic studies found that Sox9-Brn2 and Isl1-Lhx3 regul

79 However, recent genetic studies have added unexpected twists to this mec

80 Genetic studies have allowed the identification of sever

81 Mouse and human genetic studies have also revealed physiological roles f

82 Molecular genetic studies have also shown that common physical and

83 A wealth of population genetic studies have documented that many successful bio

84 Genetic studies have elucidated critical roles of Piwi p

85 Genetic studies have enabled the identification of a set

86 Furthermore, quantitative genetic studies have failed to associate naturally occur

87 Genetic studies have found that a common polymorphic var

88 Genetic studies have identified >100 components that par

89 Genetic studies have identified 163 susceptibility loci

90 Recent genetic studies have identified a few loci associated wi

91 Genetic studies have identified a glutamate-ammonia liga

92 Although genetic studies have identified AD-associated SNPs in AP

93 Genetic studies have identified several genes and genomi

94 Recent genetic studies have identified some alleles that are as

95 Human genetic studies have identified the neuronal RNA binding

96 Molecular genetic studies have identified transduction and transcr

97 Although genetic studies have implicated autoimmune processes in

98 Genetic studies have implicated de novo cysteine biosynt

99 Previous genetic studies have implicated regulatory mechanisms co

100 Human genetic studies have implicated the voltage-gated sodium

101 In addition, several biochemical and genetic studies have indicated an inhibitory role of hum

102 Although extensive genetic studies have indicated that the Wzy-dependent bi

103 ions account for 85-90% of GISTs; subsequent genetic studies have led to the identification of mutati

104 dies with longitudinal data on relapse, past genetic studies have not attempted to identify genetic f

105 In the past two decades, genetic studies have provided important insights into th

106 Recent genetic studies have provided overwhelming evidence of t

107 Genetic studies have recently identified CACNA1C as a ca

108 To date, genetic studies have reported 17 independent signals for

109 Post-mortem brain analyses and some genetic studies have reported interneuronal deficits and

110 Genetic studies have revealed significant overlaps of ri

111 Recent genetic studies have revealed that NLRC5 is a major targ

112 Large-scale genetic studies have revealed that rare sequence variant

113 Molecular genetic studies have revealed the functional basis for s

114 Genetic studies have revealed the involvement of hundred

115 While previous genetic studies have shed some light on the evolutionary

116 Recent genetic studies have shown that mutations in the ER gene

117 Genetic studies have shown that obesity risk is heritabl

118 In mammals, genetic studies have shown that this process relies on s

119 Genetic studies have shown the association of Parkinson'

120 Linguistic, archaeological, and genetic studies have shown the complex nature of the pro

121 bility of stone disease is known, and recent genetic studies have successfully identified genes that

122 e most widely used mammalian model organism, genetic studies have suffered from limited mapping resol

123 Several genetic studies have suggested SORCS2 to confer risk of

124 At the same time, population-genetic studies have suggested that genetically diverse

125 he transmembrane fusion subunit GP2, and our genetic studies have suggested that these small-molecule

126 SIGNIFICANCE STATEMENT: Recent genetic studies have underscored the emerging role of mi

127 Genetic studies have validated the pathway for phosphati

128 Multiple small human genetic studies have variably linked single nucleotide p

129 Recent human-genetics studies have come to different conclusions rega

130 onal importance, no large-scale neuroimaging genetics studies have targeted the contributions of gene

131 Our genetic studies highlight the heightened vulnerability o

132 Genetic studies highlight the potential role of estrogen

133 ecause of previously published seminal mouse genetic studies; however, mutations in MITF have never b

134 review uses multiple lines of evidence from genetic studies, human tissue, induced pluripotent stem

135 ilon2, APOE epsilon3, and APOE epsilon4, and genetic studies identified ApoE4 as the strongest geneti

136 Our genetic studies identified biallelic mutations of PRUNE1

137 Classical genetic studies identified five major SIX-ROWED SPIKE (V

138 Age strongly impaired IL-22 responses, and genetic studies identified several independent QTLs that

139 s view has recently been challenged by human genetic studies identifying somatic gain-of-function mut

140 ed movement execution.SIGNIFICANCE STATEMENT Genetic studies implicate Slc1a1, a gene encoding the ne

141 Genetic studies implicate these pathways widely in the i

142 Finally, genetic studies implicated the A2B adenosine receptor in

143 Further genetic studies implicated the AP-3 complex, which is a

144 hologic correlation of cutaneous lesions and genetic studies in 11 members of a family with familial

145 Here we report genetic studies in a Drosophila model to define S100A4 e

146 utational neuroscience and pharmacologic and genetic studies in animals and humans, particularly thos

147 en yeast and other eukaryotes, and molecular genetic studies in budding yeast have provided critical

148 Recent genetic studies in flowering plants suggest that differe

149 Genetic studies in fruit flies have implicated the chrom

150 recurring theme emerging from developmental genetic studies in grass models, that is that infloresce

151 nd highlight the usefulness of complex trait genetic studies in isolated populations.

152 We conducted genetic studies in Italian patients with U-HAE to identi

153 After 2 recent genetic studies in mice addressing the developmental ori

154 Genetic studies in mice have provided evidence that H-Ra

155 Future genetic studies in MS will likely focus on the role of r

156 In genetic studies in normal mammary gland epithelial and c

157 leveraging these results in combination with genetic studies in order to prioritize potential genes f

158 Moreover, genetic studies in patients suggest that SP110 plays a k

159 s to develop a set of SSR markers useful for genetic studies in sainfoin and their characterization i

160 Genetic studies in seven independent human populations i

161 Recent genetic studies in the KRN mouse model of rheumatoid art

162 Genetic studies in various fungi, particularly Saccharom

163 Through genetic studies in yeast, we demonstrate that Nfu1 funct

164 sent the most comprehensive and well powered genetic study in dementia with Lewy bodies so far.

165 raits is consistent with previous behavioral genetics studies in other species, for example in mouse,

166 atform was developed to underpin association genetics studies in the polyploid crop species Brassica

167 ake them excellent candidates for population genetic study, including a very high rate of mutation, h

168 subject to the same constraints as any other genetic study, including stringent type I error control.

169 tability of task performance, and population genetic studies indicate a genetic association with repr

170 Genetic studies indicate that Park2 is essential for hea

171 Further genetic studies indicated that the exon usage hypothesis

172 A previous genetic study indicated that the resistance of Norway sp

173 Although genetic studies initially suggested a primary role for a

174 NA sequencing has led to the introduction of genetic studies into the clinical realm.

175 The genetic study involved 673 patients with pSS from 2 Fren

176 Largely consistent with previous genetic studies it was found that deletion of bioW cause

177 nowledge-based mining system for Genome-wide Genetic studies (KGG).

178 Here our forward genetic study led to the discovery of VezA, a vezatin-li

179 Genetic studies linked FEVR with mutations in Wnt signal

180 Here we review genetic studies linking the glutamatergic system to the

181 Similar forward genetic studies may be useful to define the basis of pat

182 The novel approach furthermore suggests that genetic studies may be useful to explore the clinical re

183 Further genetic studies may reveal the basis for the low innate

184 Limited success of previous genetics studies may be attributable to heterogeneity of

185 Further neuroimaging genetics study might lead to the development of fundamen

186 use of its structural similarity to glucose, genetic studies of 1,5-AG can deliver complementary insi

187 preclinical mouse models of liver cancer and genetic studies of a human liver biopsy atlas with the a

188 )-enabled image-phenotyping pipeline for the genetic studies of abiotic stress iron deficiency chloro

189 Future genetic studies of animals and humans can delineate the

190 Genetic studies of autism spectrum disorder (ASD) have e

191 We screened 763 original genetic studies of BD or MDD that investigated genes enc

192 Experimental approaches to genetic studies of complex traits evolve with technologi

193 Genetic studies of complex traits have mainly identified

194 cipate that GWAX will prove useful in future genetic studies of complex traits in large population co

195 Genetic studies of disease can identify novel drug targe

196 Genetic studies of dormancy are challenging, because the

197 llite markers will be the powerful tools for genetic studies of E.(M.) onukii and improve understandi

198 Genetic studies of eczema have identified many genes, wh

199 ted SpCas9 genome editing can enable reverse genetic studies of gene function in the brain.

200 Only a few genetic studies of growth retardation associated with th

201 ost racially/ethnically diverse fine-mapping genetic studies of HDL-C, LDL-C, and triglycerides to-da

202 Genetic studies of human disease have traditionally focu

203 og of IFI16, this system is not suitable for genetic studies of IFI16.

204 Genetic studies of intellectual disability and identific

205 e, Web of Science, and HuGENET databases for genetic studies of keratoconus published from 1950 to Ju

206 e pre-existing variant databases in pursuing genetic studies of Korean individuals.

207 acilitating the functional interpretation of genetic studies of limb malformations.

208 variation across the genome to inform future genetic studies of MDD.

209 Molecular genetic studies of model plants in the past few decades

210 Future genetic studies of musical abilities should involve larg

211 ed in two independent samples, the Yale-Penn genetic studies of opioid, cocaine and alcohol dependenc

212 tibility factor genes cifA and cifB pioneers genetic studies of prophage WO-induced reproductive mani

213 strates the potential of using biomarkers in genetic studies of psychiatric disorders, and may help t

214 Genetic studies of rare and endangered species often foc

215 However, genetic studies of rare familial forms have led to the i

216 ting data from GWAS analyses with those from genetic studies of regulatory variation, it is possible

217 ot enriched in genomic regions identified in genetic studies of schizophrenia and do not reflect dire

218 After two decades of frustration, genetic studies of schizophrenia have entered an era of

219 Large-scale genetic studies of schizophrenia have increased the numb

220 Genetic studies of serogroup 6 isolates ofStreptococcus

221 However, recent high-resolution population genetic studies of TAS2Rs suggest that demographic event

222 Genetic studies of the Escherichia coli serine receptor

223 Recent identification and genetic studies of the plant purinoceptor, P2K1 (also kn

224 Although many genetic studies of tropical forest fragmentation have be

225 Genetic study of 7 genes (LDLR, APOB, PCSK9, APOE, STAP1

226 ow up, 2 cohorts (GeneSTAR, the family-based Genetic Study of Atherosclerosis Risk [n=543], and CCHS,

227 So far, to our knowledge, no large-scale genetic study of dementia with Lewy bodies has been done

228 s the utility of extreme trait selection for genetic study of intelligence and suggests that extremel

229 fy new susceptibility loci, we carried out a genetic study of migraine on 59,674 affected subjects an

230 nce use disorder datasets: the Collaborative Genetic Study of Nicotine Dependence (ascertained for to

231 c diseases, and serves as an example for the genetic study of other diseases.

232 etics, and Environment (SAGE); the Yale-Penn genetic study of substance dependence; and the National

233 prospective, population-based, clinical and genetic study of sudden cardiac death among children and

234 This, the largest genetic study of VUR to date, highlights the 10q26 regio

235 In this first large-scale neuroimaging genetics study of the human nicotinic receptor system (t

236 Thus far, the majority of the genetic studies on atopic diseases have used populations

237 Genetic studies on disease associations and functional a

238 However, the lack of parallel genetic studies on gall-forming arthropods limits our ab

239 Pharmacological and genetic studies on human/murine platelets revealed that

240 Recent genetic studies on mtDNA have shown reciprocal monophyly

241 to-transfect, while facilitating fundamental genetic studies on numerous diverse microbes.

242 ed genome sequence will permit sophisticated genetic studies on stem cells and regeneration using M.

243 Whereas genetic studies on the origin of B. dendrobatidis have i

244 Population genetics studies on non-model organisms typically involv

245 of the results of clinical, pathologic, and genetic studies performed in a single male infant observ

246 pensive genotyping methods are essential for genetic studies requiring large sample sizes.

247 Histopathologic, immunohistochemical, and genetic study results of tumor specimens and saliva.

248 These mouse genetic studies reveal that chronic necroptosis may unde

249 Biochemical and genetic studies reveal that the products of two genes th

250 Our genetic studies reveal that the ubiquitous heterodimeric

251 Biochemical, behavioral and genetic studies revealed CRHR1 as a possible candidate g

252 onsistent with these ex vivo findings, mouse genetic studies revealed that ADAMTS3 is required for ly

253 Previous genetic studies revealed that mutations in protocadherin

254 Mouse genetic studies show that elevated erythrocyte Sphk1-ind

255 Genetic studies showed that ALB4 and STIC2 act together

256 Human genetic studies showed that mutations in IRF6 lead to cl

257 la melanogaster has been at the forefront of genetic studies since before the discovery of DNA.

258 For genetic studies, statistically significant variants expl

259 es is an important initial component of many genetic studies such as mutation detection, linkage and

260 rent ADF/Cofilins (Cof1, Cof2, and ADF), and genetic studies suggest that in vivo they perform both o

261 Genetic studies suggest that SMN-1 promotes Arp2/3 activ

262 Genetic studies suggest that these inhibitors act throug

263 Mouse models and genetic studies suggest the involvement of TH1 and type

264 Previous reverse genetic studies suggested that the roles of VRN1 and FT

265 A previous genetic study suggested that the endoplasmic reticulum a

266 Further biological and genetic studies support a working model where rapsyn, a

267 Although genetic studies support cytoneme involvement in morphoge

268 Results of this genetic study support a possible role for the mineraloco

269 in tambaqui, which will be useful to enhance genetic studies that can be applied in breeding programs

270 cost effective approach for population level genetic studies that require large numbers of samples su

271 We demonstrate by molecular genetic studies that SEEDSTICK (STK), a transcription fa

272 nvolved in autophagy have been identified by genetic studies, the mechanism accounting for how these

273 We show that in the context of medical genetic studies this improves the resolution of compound

274 Genetic studies, though limited, have demonstrated both

275 sm has been largely invisible to genome-wide genetic studies thus far, we describe a way to analyze i

276 We used functional genetic studies to determine whether the intrinsic apopt

277 Here, we conducted genetic studies to investigate the role of Utf1 (Undiffe

278 ndings demonstrate the promise of broadening genetic studies to systematically search for well indivi

279 ional phenotype data previously collected by genetic studies to tackle phenotypic heterogeneity in MD

280 However, genetic studies to test the underlying assumption of res

281 2017 winner, Jonathan Hodgkin, used elegant genetic studies to unravel the sex determination pathway

282 In the present study, we conducted a human genetic study to assess the association of EFNB3 single

283 In this first GWAS of AOM and the largest OM genetic study to date, we identify the first genome-wide

284 Modern population genetics studies typically involve genome-wide genotypin

285 Genetic studies uncover a mutation in a widely conserved

286 Our molecular and genetic studies uncover PI3K/AKT2 as a direct PDGFA targ

287 Genetic studies uncovered heterozygous missense mutation

288 Also, genetic studies using the Mendelian randomization design

289 module identification framework for imaging genetic studies using the tissue-specific functional int

290 Most previous genetic studies utilized European and Asian subjects to

291 The Family Interview for Genetic Studies was administered to all participants and

292 Genetic study was performed in 47 patients and 30 pathog

293 By combining Oxi-BTH assays, NMR, and genetic studies, we also demonstrate that two intermolec

294 By pharmacologic and genetic studies, we identify FKBP12 as a novel hepcidin

295 In this genetic study, we included 1162 patients with sarcoma fr

296 4) and a confirmed polygenic nature, initial genetic studies were mostly underpowered.

297 Human genetic studies, when considered with the results of ran

298 data provides a rich potential resource for genetic studies which may allow for greater understandin

299 Ultimately, the goal of genetics studies will be to translate genetics to patien

300 This was revealed by genetic studies with double mutants including carotenoid