ライフサイエンスコーパス: genetic susceptibility

1 port previous reports of a relationship with genetic susceptibility.

2 ther these associations might be modified by genetic susceptibility.

3 As), but little is known about the molecular genetic susceptibility.

4 lieved to involve environmental exposure and genetic susceptibility.

5 alleles appear to be indicative of a common genetic susceptibility.

6 lt of higher viral loads, comorbidities, and genetic susceptibility.

7 on to advanced AMD, which may be modified by genetic susceptibility.

8 he human DQ8 gene, which confers moderate CD genetic susceptibility.

9 lieved to involve environmental exposure and genetic susceptibility.

10 individuals never develop HCC, suggesting a genetic susceptibility.

11 tions with other possible factors, including genetic susceptibility.

12 on the same importance as the tumor type and genetic susceptibility.

13 sure, genetic and epigenetic mechanisms, and genetic susceptibility.

14 nvironmental factors acting on an underlying genetic susceptibility.

15 additional interacting loci are required for genetic susceptibility.

16 loci (Crgn3 through 7), largely explain this genetic susceptibility.

17 than in the half of the population with low genetic susceptibility.

18 diet intervention are different according to genetic susceptibility.

19 tions are the same for people with different genetic susceptibilities.

20 everal traits with significant sex biases in genetic susceptibilities.

21 loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes

22 nally concentrated on environmental stimuli, genetic susceptibilities, adaptive immune responses, and

23 asthma has concentrated on initial stimuli, genetic susceptibilities, adaptive immune responses, and

24 priate experimental model which incorporates genetic susceptibility, aging and prolonged environmenta

25 The aim of this study was to identify common genetic susceptibility alleles for gallbladder cancer.

26 These findings identified new genetic susceptibility alleles for lung cancer in never-

27 66Met mouse line to characterize how a known genetic susceptibility alters both baseline translationa

28 Genetic susceptibility and environmental factors (such a

29 1D) results from a complex interplay between genetic susceptibility and environmental factors that ha

30 Genetic susceptibility and environmental influences are

31 concern that involves an interaction between genetic susceptibility and exposure to environmental cue

32 Since an increased mortality reflects both genetic susceptibility and long-term impacts of parental

33 pisode of KA are due to differences in human genetic susceptibility and not to modifications of paras

34 t work has advanced our understanding of the genetic susceptibility and pathogenesis of Henoch-Schonl

35 dual variability in risk suggests a role for genetic susceptibility and provides an opportunity to id

36 a link, as we currently understand, between genetic susceptibility and the environment in predisposi

37 The study of twins allows us to separate genetic susceptibility and the influence of environmenta

38 is necessary in order to clearly define the genetic susceptibility and the pathogenesis of Henoch-Sc

39 Our findings establish a link between CAD genetic susceptibility and the response to inflammatory

40 This study provides novel insight into the genetic susceptibility and therapeutic rationale of KBD.

41 ies might help to identify proxy measures of genetic susceptibility and thereby inform models of risk

42 ote chronic inflammation in individuals with genetic susceptibility and/or other environmental factor

43 atments (eg, alkylating agent chemotherapy), genetic susceptibilities, and other risk factors (eg, vi

44 orial and exogenous or endogenous exposures, genetic susceptibility, and chance have roles.

45 ation of factors, including viral pathogens, genetic susceptibility, and commensal microflora, can le

46 ccount for this variability include climate, genetic susceptibility, and environmental antigen exposu

47 ntioxidants might be modified by life stage, genetic susceptibility, and environmental sources of oxi

48 e interaction of environmental exposures and genetic susceptibility, and major research efforts are u

49 he interactions between enteric bacteria and genetic susceptibilities are major contributors of IBD e

50 explore the impact of aging and the role of genetic susceptibility as modifiers of risk in diseases

51 The mechanisms underlying genetic susceptibility at loci discovered by genome-wide

52 arranted to better understand the underlying genetic susceptibility between PD and hormone-related ca

53 vation we examined for pleiotropy, or shared genetic susceptibility, between CRC and the 200 establis

54 obes with hosts that contain a background of genetic susceptibility can play a role in autoimmune pat

55 is of depression in which chronic stress and genetic susceptibility cause changes in the strength of

56 of MR exists in the community, supporting a genetic susceptibility common to primary and nonprimary

57 e/chronic tics may have different underlying genetic susceptibility compared with OCD alone.

58 These results suggest that shared genetic susceptibility contributes modestly to MDD and A

59 stion that remains largely unanswered is how genetic susceptibility contributes to this process and,

60 hracyclines and cardiomyopathy suggests that genetic susceptibility could play a role.

61 rly life environmental factors with distinct genetic susceptibility elements at 5q22 (TSLP) and 2p23

62 ular, tobacco and excessive alcohol intake), genetic susceptibility, environmental exposures, host ef

63 ight result from a complex interplay between genetic susceptibility, environmental factors, and alter

64 The importance of genetic susceptibility, epigenetics, aging, and the mode

65 e major [C] allele of ABCB11 c.1331 T>C is a genetic susceptibility factor for HCV infection, but not

66 he apolipoprotein E (apoE) gene is the major genetic susceptibility factor for late-onset Alzheimer's

67 implicate this PARK2 germline mutation as a genetic susceptibility factor for lung cancer.

68 nucleotide polymorphism (SNP) in PROX1 is a genetic susceptibility factor for type 2 diabetes.

69 7insMTTTVP polymorphism in TIM1 is the first genetic susceptibility factor shown to predispose to HAV

70 ting of 32 autoinflammatory genes to explore genetic susceptibility factor(s) to Schnitzler syndrome.

71 Genetic susceptibility factors for adult psychiatric ill

72 Most studies aiming to identify genetic susceptibility factors for LOAD have focused on

73 No confirmed genetic susceptibility factors have been identified usin

74 To identify additional genetic susceptibility factors of asthma in European Ame

75 ory lipid classes and subclasses, and common genetic susceptibility factors present in both disease l

76 over the past decades, little is known about genetic susceptibility factors that may predispose indiv

77 enome-wide association studies have revealed genetic susceptibility factors that play a role in the f

78 We believe that studies of certain SZ genetic susceptibility factors with neurodevelopmental i

79 ons brought about by the combined effects of genetic susceptibility factors, nongenetic experiences a

80 n at average risk of breast cancer (no known genetic susceptibility, family history, previous breast

81 pical activity in this circuitry may reflect genetic susceptibility for ASD, with increased activity

82 To further understand the genetic susceptibility for CLL and identify common loci

83 umatoid arthritis, little is known about the genetic susceptibility for EBA.

84 NGS panel in clinic and indicate a conserved genetic susceptibility for epilepsy between Chinese and

85 iated with reduced risk of GA and may modify genetic susceptibility for progression to GA.

86 Genetic susceptibility for schizophrenia had a much stro

87 ibution of common polygenic variation to the genetic susceptibility for schizophrenia.

88 partly dependent on the presence of existing genetic susceptibility for SCZ.

89 , our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer

90 of cow's milk-based formula for infants with genetic susceptibility for type 1 diabetes reduced the c

91 ping GA independent of age, smoking, and AMD genetic susceptibility from the CFH or ARMS2 genes.

92 on, and both the psoriatic transcriptome and genetic susceptibility further implicate NF-kappaB in ps

93 these sarcoidosis phenotypes have different genetic susceptibility, genomic distributions, and cellu

94 cases of diabetes that occurred in the high genetic susceptibility group compared with the low genet

95 c susceptibility group compared with the low genetic susceptibility group.

96 Genetic susceptibility has been implicated in congenital

97 , an agnostic, genome-wide search for shared genetic susceptibility has not been performed.

98 vironmental risk factors in conjunction with genetic susceptibility have been proposed with respect t

99 but the genes and pathways involved in this genetic susceptibility have remained elusive.

100 inucleotide repeat disorders and any further genetic susceptibilities in individual disorders, geneti

101 To investigate the role of genetic susceptibility in murine schistosomiasis, quanti

102 The results support genetic susceptibility in the familial recurrence of ASD

103 otype of type 1 diabetes resulting from high genetic susceptibility in the first six decades of life.

104 tial progress has been made in understanding genetic susceptibility in the past 5 years on the basis

105 tudies found moderating effects with PTE and genetic susceptibilities including dopamine transporter,

106 cts are most pronounced in individuals whose genetic susceptibility increases responsiveness to catec

107 damage in addition to allergens, underlying genetic susceptibility, inflammatory and structural cell

108 focused on the hypothesis that an underlying genetic susceptibility interacts with folate-sensitive m

109 In subjects with moderate genetic susceptibility, intestinal microbiota changes ma

110 (IBD) involves interactions between the host genetic susceptibility, intestinal microflora and mucosa

111 smoking, hypertension, and atherosclerosis, genetic susceptibility is a primary contributor to the d

112 EoE genetic susceptibility is mediated by EoE-specific and g

113 reported in GAD, however direct evidence for genetic susceptibility is missing.

114 e-responsive CD4(+) T cells in the lung, and genetic susceptibility is primarily linked to HLA-DPB1 a

115 f age-related macular degeneration (AMD) and genetic susceptibility is unknown.

116 Comparison of genetic pathways as well as genetic susceptibility loci between CD and other autoimm

117 ction, for which the goal is to discover new genetic susceptibility loci by leveraging G-E interactio

118 s of Paneth cells associated with particular genetic susceptibility loci can be used to define specif

119 Advances have been made in identifying genetic susceptibility loci for autoimmune diseases, but

120 NA pooling, we previously identified 5 novel genetic susceptibility loci for Behcet's disease.

121 rols of East Asian women to search for novel genetic susceptibility loci for breast cancer.

122 We discuss genetic susceptibility loci for CD and how these affect

123 leukocyte antigen (HLA) genes are candidate genetic susceptibility loci for childhood acute lymphobl

124 Genetic susceptibility loci for Crohn's disease (CD) are

125 To identify genetic susceptibility loci for DLBCL, we conducted a me

126 rdiotoxicity, leading to the hypothesis that genetic susceptibility loci for hypertension may serve a

127 Several confirmed genetic susceptibility loci for lupus have been describe

128 These findings provide evidence of novel genetic susceptibility loci for lupus in African America

129 To identify genetic susceptibility loci for MacTel, we performed a g

130 study substantially increases the number of genetic susceptibility loci for NSCLP and provides impor

131 se burden as quantitative traits to identify genetic susceptibility loci for OA.

132 ide polymorphisms (SNPs) within 16 confirmed genetic susceptibility loci for SLE were genotyped in a

133 Known genetic susceptibility loci for type 2 diabetes (T2D) ex

134 Although approximately 20 common genetic susceptibility loci have been identified for bre

135 While numerous genetic susceptibility loci have been identified for cli

136 nflammatory skin disorder for which multiple genetic susceptibility loci have been identified, but fe

137 influencing dyslipidemia and currently; 157 genetic susceptibility loci have been reported to be ass

138 Herein, we report the first evidence of genetic susceptibility loci identified by OA-related bio

139 imated heritability for PsA, the majority of genetic susceptibility loci identified to date are share

140 ulation-specific loci as well as many shared genetic susceptibility loci in comparisons of Asian and

141 Here we map common genetic susceptibility loci in European ancestry women f

142 CRC by incorporating information from common genetic susceptibility loci.

143 adenocarcinoma may be attributable to shared genetic susceptibility loci.

144 cestry information has been used to identify genetic susceptibility loci.

145 These results provide an example of a shared genetic susceptibility locus for bipolar disorder and MD

146 FTO is the strongest known genetic susceptibility locus for obesity.

147 In sum, developing a genetic susceptibility map and keeping it updated are ef

148 ues by developing a nicotine dependence (ND) genetic susceptibility map based on the results obtained

149 on of environmental risk factor exposure and genetic susceptibility may contribute to the etiology of

150 ught to be mediated by the interplay between genetic susceptibility, microbial dysbiosis, and environ

151 risk implies that individual differences in genetic susceptibility might be at work.

152 ked to early life stress, and epigenetic and genetic susceptibility might explain some aspects of ado

153 y of environmental influences and individual genetic susceptibility modulates disease presentation an

154 Therefore, we examined the shared genetic susceptibility modulating schizophrenia and brai

155 ariants at the PARK2 locus contribute to the genetic susceptibility of ADHD.

156 central nervous system may contribute to the genetic susceptibility of ASD.

157 ny studies have attempted to investigate the genetic susceptibility of Attention-Deficit/Hyperactivit

158 h autoimmunity and have implications for the genetic susceptibility of autoimmune disease.

159 Our analysis supports a broader role for genetic susceptibility of both sporadic and familial cas

160 results indicate that CNVs contribute to the genetic susceptibility of common childhood obesity in su

161 imental transmission model for assessing the genetic susceptibility of goats to scrapie.

162 on studies (GWAS) have been conducted on the genetic susceptibility of hepatitis B virus (HBV)-relate

163 mplex gene-environment interactions in which genetic susceptibility of HLA type 2 antigen presentatio

164 In addition to revealing the genetic susceptibility of neurodegenerative disease, gen

165 s of synaptic transmission contribute to the genetic susceptibility of schizophrenia.

166 of the infectious agent, in addition to the genetic susceptibility of the host, play an important ro

167 failure of memory T cell responses; and (v) genetic susceptibility of the host.

168 le knowledge about underlying mechanisms and genetic susceptibility of the various adverse effects.

169 er variation in Fcgr3 partially explains the genetic susceptibility of the Wistar-Kyoto (WKY) rat to

170 n blacks is related to socioeconomic status, genetic susceptibility, or both.

171 H pathogenesis and indicate that part of the genetic susceptibility overlaps with that for other immu

172 This relation could be modified by genetic susceptibility, particularly related to the C3 g

173 provide an update on recent advances in the genetic susceptibility, pathogenesis and treatment of He

174 te recent progress, our understanding of the genetic susceptibility, pathogenesis and treatment of He

175 on breast cancer incidence of low-penetrance genetic susceptibility polymorphisms and environmental f

176 R3 and HLA-DR2, is one of the most important genetic susceptibility regions for systemic lupus erythe

177 Few studies have evaluated genetic susceptibility related to diabetes and obesity a

178 To identify genetic variants contributing to genetic susceptibility shared across interview-generated

179 atio for a single variant as contributors to genetic susceptibility shared across the partial epileps

180 ve pulmonary disease are never-smokers, most genetic susceptibility studies have not focused on this

181 sease phenotypes that require both aging and genetic susceptibility, such as pronounced dendrite dege

182 between cumulative environmental factors and genetic susceptibility, such that no one factor dictates

183 Be to T cells match those implicated in the genetic susceptibility, suggesting that the HLA contribu

184 s sample of first-degree relatives receiving genetic susceptibility testing for AD, an APOE epsilon4+

185 Genetic susceptibility testing for Alzheimer disease (AD

186 ide association studies continue to identify genetic susceptibilities that are both unique to coeliac

187 diotoxicity and perhaps by identification of genetic susceptibilities to cardiovascular diseases; opt

188 lassify people according to their underlying genetic susceptibility to a disease is increasing with n

189 To identify human genetic susceptibility to A(H7N9) infection, we performe

190 ay account for a significant fraction of the genetic susceptibility to AD and FTD.

191 Our findings indicate shared genetic susceptibility to AD and small vessel stroke and

192 ity variants, but is associated with reduced genetic susceptibility to Alzheimer and coronary artery

193 in understanding the molecular basis for the genetic susceptibility to atherosclerosis.

194 sociated interventions in a mouse model with genetic susceptibility to autoimmune disease.

195 Genetic susceptibility to autoimmunity is frequently ass

196 ommon variants of small effect contribute to genetic susceptibility to Barrett's esophagus and that S

197 he genetic and biological basis of inherited genetic susceptibility to BCP-ALL and the influence of c

198 Genetic susceptibility to beryllium-induced disease is s

199 These results provide further insight into genetic susceptibility to breast cancer and will improve

200 se findings provide convincing evidence that genetic susceptibility to breast cancer varies by tumor

201 Epidemiologic data on genetic susceptibility to cardiovascular effects of arse

202 Understanding of the host genetic susceptibility to carriage of, and infections, d

203 Genetic susceptibility to CBD has been associated with c

204 tency and differences in the determinants of genetic susceptibility to CHD in diabetic patients and t

205 he genetic and biological basis of inherited genetic susceptibility to CLL.

206 Genetic susceptibility to colorectal cancer is caused by

207 using biology to inform analyses to identify genetic susceptibility to complex diseases.

208 n vitamin D receptor (VDR) polymorphisms and genetic susceptibility to components of the metabolic sy

209 SES groups to reduce the expression of their genetic susceptibility to coronary artery disease.

210 indication that MCC might confer alterative genetic susceptibility to CRC in individuals with schizo

211 Genetic susceptibility to CRC in the general population

212 sight into the biological basis of inherited genetic susceptibility to CRC, and identify risk factors

213 he genetic and biological basis of inherited genetic susceptibility to CRC.

214 he genetic and biological basis of inherited genetic susceptibility to CRC.

215 The residual genetic susceptibility to crescentic glomerulonephritis

216 Study of the genetic susceptibility to CRS might be a valuable strate

217 morbidity and we therefore hypothesized that genetic susceptibility to CVID may overlap with autoimmu

218 d the importance of pancreatic beta-cells in genetic susceptibility to diabetes.

219 iations in expression of ABCB11 might confer genetic susceptibility to diet-induced hyperlipidemia an

220 This is one of the first studies to assess genetic susceptibility to dioxins.

221 phisms of the classical HLA genes as driving genetic susceptibility to disease, our study additionall

222 Research into genetic susceptibility to endometrial cancer and the pot

223 ence of an additional region of interest for genetic susceptibility to endometrial cancer.

224 ese results may advance our understanding of genetic susceptibility to EOC.

225 Furthermore, it seems that an underlying genetic susceptibility to Ewing's sarcoma, if it exists,

226 lation of ERK2 signaling might contribute to genetic susceptibility to FASD.

227 These data substantiate that genetic susceptibility to GBM and non-GBM tumors are hig

228 uggesting a broader role for this network in genetic susceptibility to HGSOC.

229 Our data reveal important differences in genetic susceptibility to HSCT-associated TMA based on r

230 esting impaired HNF4A binding could underlie genetic susceptibility to IBD.

231 gle-nucleotide polymorphisms associated with genetic susceptibility to in-hospital acute kidney injur

232 In addition, genetic susceptibility to increased heart rate is associ

233 Systematic identification of genetic susceptibility to infection is being undertaken

234 ggesting that factors--such as divergence in genetic susceptibility to infection--may influence infec

235 s are also highly relevant for understanding genetic susceptibility to influenza virus infections in

236 , genetic modifiers for BMPR2 penetrance and genetic susceptibility to IPAH.

237 Furthermore, genetic susceptibility to later menopause is associated

238 ociation studies have been used to study the genetic susceptibility to leprosy,while whole exome sequ

239 dings provide further evidence for inherited genetic susceptibility to lung cancer and its biological

240 n 1000 candidate-gene association studies on genetic susceptibility to lung cancer have been publishe

241 Furthermore, our results suggest that the genetic susceptibility to MDD differs between adult- and

242 er cases and 5,110 cancer-free controls) and genetic susceptibility to mLOY.

243 istent with MGUS being a marker of inherited genetic susceptibility to MM.

244 Genetic susceptibility to multiple sclerosis (MS) has be

245 ing linked pathways (eg, adrenergic) between genetic susceptibility to NAFLD and metabolic syndrome.

246 resent a population of interest for studying genetic susceptibility to neoplasia.

247 data suggest that the ADM gene modulates the genetic susceptibility to nephropathy progression.

248 erall, these analyses offer an evaluation of genetic susceptibility to NFT, a common end point for mu

249 6 C/T nonsynonymous (p.Glu167Lys) variant in genetic susceptibility to nonalcoholic fatty liver disea

250 Our analyses indicate that host genetic susceptibility to norovirus and rotavirus infect

251 s of NSCL/P advance our understanding of the genetic susceptibility to NSCL/P.

252 are no published studies investigating host genetic susceptibility to NTS in African populations.

253 Common genetic susceptibility to obesity has been shown to modi

254 However, the mechanisms through which genetic susceptibility to obesity operates are not well

255 estraint, and weakest in the highest tertile.Genetic susceptibility to obesity was partially mediated

256 control over eating appear to attenuate the genetic susceptibility to obesity.

257 e whether eating behaviors mediate or modify genetic susceptibility to obesity.Genetic risk scores fo

258 uncover heritable traits that are related to genetic susceptibility to OCD.

259 s suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat

260 Mechanisms of genetic susceptibility to ozone-induced lung inflammatio

261 We sought to investigate genetic susceptibility to PA.

262 HLA locus and imply that the immune-related genetic susceptibility to PD is likely to be more widesp

263 To characterize genetic susceptibility to PM-associated QT prolongation

264 he genetic and biological basis of inherited genetic susceptibility to RCC.

265 lts are the first reported evidence of human genetic susceptibility to S. aureus infection.

266 Here we provide evidence that a genetic susceptibility to SLE protects against cerebral

267 Genetic susceptibility to systemic lupus erythematosus (

268 Genetic susceptibility to T1D causes alterations in the

269 TCR sequences are important determinants of genetic susceptibility to T1D.

270 18 loci, together accounting for >15% of the genetic susceptibility to testicular germ cell tumour (T

271 ur study provides important insights linking genetic susceptibility to the underlying mechanism of RG

272 se data provide substantial new evidence for genetic susceptibility to this B cell malignancy and poi

273 These data provide further evidence for genetic susceptibility to this B-cell hematological mali

274 These data provide further evidence for genetic susceptibility to this B-cell hematological mali

275 ne genetic architecture of CAD, showing that genetic susceptibility to this common disease is largely

276 nephropathy, perhaps explaining some of the genetic susceptibility to this condition.

277 tion studies have found >60 loci that confer genetic susceptibility to type 1 diabetes (T1D).

278 It is not known how frequently genetic susceptibility to type 1 diabetes leads to a dia

279 INTERPRETATION: Genetic susceptibility to type 1 diabetes results in non

280 were in the half of the population with high genetic susceptibility to type 1 diabetes than in the ha

281 the half of the population with high or low genetic susceptibility to type 1 diabetes.

282 lanoma (UM) has been strongly suggested, the genetic susceptibility to UM is currently vastly unexplo

283 ing candidate genes and WMH to elucidate the genetic susceptibility to WMH and tested associated vari

284 Genetic susceptibility to young-onset type 1 diabetes is

285 ed weight gain, particularly in those with a genetic susceptibility toward overweight.

286 cardiomyocytes (CMs), and to explore whether genetic susceptibility underlies the pathophysiology of

287 to establish the molecular identity of such genetic susceptibility variants by genome-wide associati

288 to the likely functional targets of germline genetic susceptibility variants for ovarian cancer.

289 diabetic kidney disease, efforts to identify genetic susceptibility variants have had limited success

290 that body fatness accentuates the effects of genetic susceptibility variants in hypertriglyceridemia,

291 This genetic susceptibility was recently linked to polymorphi

292 ith improved understanding of the underlying genetic susceptibility, we can identify targets to halt

293 y variants which contribute to the remaining genetic susceptibility, we performed the largest meta-an

294 disease that results from the interaction of genetic susceptibility with aging and environmental fact

295 at ADHD frequently co-occurs with and shares genetic susceptibility with autism spectrum disorder (AS

296 should integrate underlying risk related to genetic susceptibility with cell-type specific epigeneti

297 The interaction of genetic susceptibility with lifestyle factors may play a

298 n of adherence to the Mediterranean diet and genetic susceptibility with progression to advanced AMD.

299 has also been shown to enhance the effect of genetic susceptibility with regards to the presence and

300 The study of this genetic susceptibility with the use of DS as a model of