ライフサイエンスコーパス: genetic system

1 exemplify primitive states of the developing genetic system.

2 incorporation of phosphate and an RNA-based genetic system.

3 erproduce SHI utilizing a recently developed genetic system.

4 hampered by the lack of a tenable chlamydial genetic system.

5 tly to accelerate the use of S. viridis as a genetic system.

6 acilitating rapid transfer to any compatible genetic system.

7 related to the underlying properties of the genetic system.

8 ymes can serve as an experimental model of a genetic system.

9 it is one of few archaea with an established genetic system.

10 hicken cells to dissect its role in a stable genetic system.

11 red by IFN-inhibited PKR function in a yeast genetic system.

12 nctions of PARP in a sophisticated microbial genetic system.

13 ement using a recently described MHV reverse genetic system.

14 rin affinity modulation in a tractable model genetic system.

15 building blocks for a large-sized artificial genetic system.

16 e switching) embedded in a uniquely powerful genetic system.

17 e easily adaptable to circuit mapping in any genetic system.

18 for studying tendon biology in a vertebrate genetic system.

19 otein expression is critical when optimizing genetic systems.

20 on of the relative complexities of different genetic systems.

21 are assembled from subunits derived from two genetic systems.

22 n and investigate its consequences for model genetic systems.

23 organism-based research and the evolution of genetic systems.

24 may be a common force in standard population genetic systems.

25 troses) that may also be able to function in genetic systems.

26 ant bacterial pathogens with no or difficult genetic systems.

27 cal processes because of a lack of tractable genetic systems.

28 ruction and systematic optimization of large genetic systems.

29 bility of genome sequence data and molecular genetic systems.

30 ays and the evolutionary dynamics of complex genetic systems.

31 d, yet little is known about how they modify genetic systems.

32 typing individual sites, proteins, or entire genetic systems.

33 ractive complementary technology to existing genetic systems.

34 er of genetic information between successive genetic systems.

35 tructing, and characterizing such artificial genetic systems.

36 rgetic organelles with their own genomes and genetic systems.

37 nked by shared, underlying physiological and genetic systems.

38 ally interact and function together in other genetic systems.

39 h facilitate recovery of MNV using a reverse-genetics system.

40 he virus S and L segments by using a reverse genetics system.

41 at carries the mutated hPIV1 HN by a reverse genetics system.

42 nt IPNV strains using the cRNA-based reverse-genetics system.

43 ) (H3N2) by using a highly efficient reverse genetics system.

44 rtificial chromosome (BAC)-based MHV reverse genetics system.

45 virus, were generated by use of the reverse genetics system.

46 acid mutation at this site through a reverse genetics system.

47 with an antibody avidity assay based on the Genetic Systems 1/2+ O ELISA.

48 y heritable epigenetic information represent genetic systems adjunct to DNA sequences that contribute

49 ized biological parts in the construction of genetic systems aimed at eliciting of desired cellular b

50 Phage genetic systems already support the perspective that lys

51 .3 strain U201 RNA, generated from a reverse genetics system, also does not induce an IFN response.

52 Here we study a simple genetic system, an evolving RNA enzyme (ribozyme) in whi

53 rospective of Drosophila as an indispensable genetic system and discuss some of the many contribution

54 ism of aCFV, we used the geminiviral reverse genetic system and introduced a multimeric clone into th

55 The viability of xDNA as an alternative genetic system and its possible biotechnological applica

56 cking the functions of the natural DNA-based genetic system and of developing useful research tools.

57 ubstitutions were made within a TBEV reverse genetic system and recovered mutants were compared for p

58 This genetic system and related biochemical assays have now b

59 This cosmid-based genetic system and the reporter virus neutralization ass

60 should improve the engineering of synthetic genetic systems and also advance quantitative modeling o

61 They combine highly developed genetic systems and ease of use with reductions in time

62 information between organelles with distinct genetic systems and have established a new level of inte

63 Thus, we would predict that genetic systems and nervous systems would be dynamic (cy

64 Compared with genetic systems and other in vitro methods, IVT2H not on

65 Advanced recombinant genetic systems and the recent discovery of a mouse-trop

66 yeast, the genome was altered by using yeast genetic systems and then transplanted to produce a new s

67 derstanding evolutionary dynamics of complex genetic systems and unveiling structure and function of

68 By taking advantage of the available reverse genetics system and ectopic expression system for viral

69 tions at these three residues with a reverse genetics system and then investigated the molecular basi

70 oach complements the current mouse molecular genetics systems and provides a powerful means for the g

71 hat have been developed in such traditional 'genetic systems', and highlight the progress that has be

72 al tolerance mechanisms, implementation of a genetic system, and discovery of a new carbon fixation p

73 ries that unify many deeply diverged ciliate genetic systems, and a surprising evolutionary "sign cha

74 nctions of the ribosome, enabling orthogonal genetic systems, and engineering ribosomes with new func

75 f parenting on the child's physiological and genetic systems, and how interventions can improve child

76 manipulation of many organisms for which few genetic systems are available.

77 Expanded genetic systems are most likely to work with natural enz

78 r microorganisms, especially those for which genetic systems are unavailable.

79 ignature of coevolution of these two complex genetic systems as compared with inhibitory receptor-lig

80 There is no reverse genetics system available for the current epidemic virus

81 pore-forming bacterium and model prokaryotic genetic system, Bacillus subtilis, is extremely useful i

82 We used a synthetic genetic system based on ligand-induced intramembrane pro

83 A genetic system based on rpsL-streptomycin counter select

84 Here, we present a novel genetic system based on the chicken DT40 cell line, in w

85 ggest the possibility of a future eight-base genetic system based on the yDNA geometry.

86 and characterization of a novel ZIKV reverse genetics system based on a 2015 isolate from Puerto Rico

87 Therefore, we developed a reverse genetics system based on the neurovirulent Snyder Hill (

88 virus (ZEBOV) glycoprotein (GP) by a reverse genetics system based on the SAD B19 RABV wildlife vacci

89 Studies in novel genetic systems, both at the base of the land plant phyl

90 ctionality of aptazymes in fully cytoplasmic genetic systems, but also implicates general feasibility

91 ing reovirus rescue from the current reverse genetics system by 100-fold.

92 , in turn, implies that the GACTZP synthetic genetic system can explore the entire expanded sequence

93 This genetic system can therefore be employed for the testing

94 RV isolate, demonstrating that this reverse genetics system can be used to study the molecular biolo

95 This reverse genetics system can be used to study the molecular virol

96 , G, C, isoC, isoG alphabet is an artificial genetic system capable of Darwinian evolution.

97 We have developed a genetic system capable of producing modular carbon-fixin

98 In early vertebrates, a genetic system coding for ancient soft collagenous tissu

99 We analyzed various genetic systems comprising HIV-1, the malaria-causing pa

100 Both genetic systems contain two-gene operons that are transc

101 The genetic systems controlling body axis formation trace ba

102 Study of this unique genetic system coupled with proteomic analysis indicated

103 he complete genomic sequence and the reverse genetics system described herein make TV a valuable mode

104 The robust reverse genetics system described will be a valuable tool for th

105 Using the murine norovirus (MNV) reverse-genetics system, disruption of 5' end stem-loops produce

106 e that TNA could have served as an ancestral genetic system during an early stage of life.

107 To address these issues, a yeast-based genetic system enabling generation of stable strains exp

108 nity, Long and coworkers describe a powerful genetic system enabling reliable serial genetic dissecti

109 This highly efficient genetic system facilitates high-throughput functional ch

110 of other animals suggest that a pre-existing genetic system for anteroposterior head patterning was c

111 is manuscript, we describe a CRISPR-mediated genetic system for cells of the myeloid lineage in which

112 Since there is no current genetic system for Chlamydia spp., blockade of T3S was a

113 upports the development of this well-defined genetic system for conversion of methylglucuronoxylan (M

114 pressing transgenic plants may provide a new genetic system for dissecting the molecular mechanism th

115 ce because they provide a uniform and stable genetic system for functional analyses and therapeutic a

116 We have developed yeast as an expression and genetic system for functional studies of the insulin-deg

117 The development of a genetic system for making recombinant rhLCV constitutes

118 nistic information obtained in this powerful genetic system for mammalian mitosis.

119 We describe a versatile genetic system for rapid analysis of mammalian gene func

120 Here, we report on the development of a genetic system for the detection of T(12;15)(Igh-Myc) tr

121 netic bases, and they establish an important genetic system for the study of early stages of ecologic

122 the family Y Pols, and the availability of a genetic system for this archaeon should allow subsequent

123 These new genes are the basis for a novel genetic system for various mineralized tissues in skelet

124 l advances in glycan binding assays, reverse genetic systems for influenza and in X-ray crystallograp

125 We constructed reverse genetic systems for JHM.SD and JHM.WU and, utilizing the

126 of this novelty is co-option of pre-existing genetic systems for new purposes.

127 By taking advantage of the available reverse genetics system for a model arenavirus, Pichinde virus (

128 We constructed a reverse genetics system for avian paramyxovirus serotype 7 (APMV

129 the establishment of a plasmid-based reverse genetics system for equine influenza virus.

130 veloped the first, to our knowledge, reverse genetics system for HRV-C.

131 In this report, we describe a reverse genetics system for NL63, whereby five contiguous cDNAs

132 A newly described single-plasmid reverse genetics system for noroviruses has the potential to fac

133 is end, we developed a plasmid-based reverse genetics system for Orsay virus by creating transgenic C

134 This reverse genetics system for PEC provides a new tool to study the

135 s functional minigenome system and a reverse genetics system for production of infectious Junin virus

136 In this study, we constructed a reverse-genetics system for recovery of infectious APMV-3 strain

137 In this study, we constructed a reverse genetics system for recovery of infectious recombinant A

138 yxoviruses (APMVs), we constructed a reverse genetics system for recovery of infectious recombinant A

139 A reverse genetics system for the highly virulent NDV strain Banja

140 We generated a reverse genetics system for the live-attenuated MV vaccine strai

141 ing potential acceptor sites using a reverse genetics system for the moderately pathogenic strain Bea

142 investigations, we have developed a reverse-genetics system for UUKV that permits manipulation of th

143 athways confounds the development of reverse genetics systems for rotavirus.

144 rovirus (MNV) and the development of reverse-genetics systems for this virus provide an opportunity t

145 The development of reverse genetics systems for wild-type strains of CDV and the us

146 This unique genetic system further enabled us to show that expressio

147 However, the lack of a genetic system has confounded efforts to establish any r

148 Fragile X syndrome, the classical Drosophila genetic system has provided fruitful disease models.

149 The power of these genetic systems has revealed many genetic factors involv

150 gy approaches and the development of reverse genetics systems has allowed the rapid and reliable desi

151 The available data from uniparental genetic systems have already transformed our view of the

152 (HIV-1)/HIV-2 antibody screening assay, the Genetic Systems HIV-1/HIV-2 PLUS O EIA, was compared to

153 Due to the absence of a F. succinogenes genetic system, homologues in Escherichia coli were muta

154 walk virus stool RNA transfection, a reverse genetics system, IFN neutralization reagents, and shRNA

155 embers of human APOBEC3 family using a novel genetic system in Escherichia coli.

156 complex (MHC) contains the most polymorphic genetic system in humans, the human leukocyte antigen (H

157 ssues, we have developed a novel conditional genetic system in mice based on the heterologous express

158 To study CytoQC, we have employed a genetic system in Saccharomyces cerevisiae using a trans

159 Here we describe a genetic system in the nematode Caenorhabditis elegans to

160 We have created a genetic system in the yeast Saccharomyces cerevisiae to

161 We describe here a chemical genetic system in which a single Plk family member, Plk1

162 editing in human cells to create a chemical genetic system in which endogenous Plk4 can be specifica

163 other enrichment program (MEP), an inducible genetic system in which mother cells maintain a normal R

164 Using a mouse genetic system in which restricted populations of neuron

165 One of the most intriguing genetic systems in B. burgdorferi is vls recombination,

166 ough the analysis of uniparentally inherited genetic systems in Native American populations and the c

167 nsects to engineer female-specific autocidal genetic systems in the Mediterranean fruit fly, Ceratiti

168 his is the first plasmid-based virus reverse genetics system in the metazoan C. elegans.

169 ome these problems, we established a reverse genetics system in which the eight RNA polymerase I tran

170 we describe a recombinant human RSV reverse genetics system in which the red fluorescent protein (mC

171 physical characterization of a new four-base genetic system, in which all base pairs are larger than

172 Through use of an MHV reverse genetics system, in-frame deletions of the coding sequen

173 enges the understanding of even the simplest genetic systems, including the prototypical lac operon.

174 ult myocardium using a doxycycline-inducible genetic system (inducible Notch intracellular domain [iN

175 By using a cDNA-based reverse genetics system, insertions or substitutions of sequence

176 ep in synthetic biology to use an artificial genetic system inside of living bacterial cells.

177 e provides a blueprint for understanding the genetic systems involved in alkane metabolism including

178 at such pulsating response in drug-inducible genetic systems is a property emerging from the dependen

179 A common topology found in many bistable genetic systems is two interacting positive feedback loo

180 The precision of this genetic system largely depends on the specificity of Cre

181 nt gaps in our conceptual framework of early genetic systems make it difficult to imagine how a stabl

182 gent to develop representations of synthetic genetic systems more abstract than their DNA sequence.

183 The aim of synthetic biology is to make genetic systems more amenable to engineering, which has

184 This study exploits the genetic system of Salmonella enterica to examine the in

185 ccus faecalis is the most thoroughly studied genetic system of this species.

186 Animal models combined with reverse genetic systems of anellovirus have not been developed.

187 e ancient events can significantly shape the genetic systems of the recipients and can play a part in

188 Using a reverse genetics system of a prototypic arenavirus, Pichinde vir

189 A reverse genetics system of PRRSV North American prototype VR-233

190 Insects carrying a female-specific autocidal genetic system offer an attractive alternative to conven

191 Other genetic systems operate and affect the various outcomes

192 n give some insights into the origins of new genetic systems or new phenotypic characters.

193 However, due to the lack of genetic systems, protein transfer by the C. burnetii Dot

194 Utilizing a reverse-genetics system recently developed, we report the rescue

195 Using a reverse genetics system, recombinant hMPVs (rhMPVs) lacking eith

196 How divergent genetic systems regulate a common pathway during the dev

197 ing region; however, it remains elusive what genetic system regulates the Hand2-Shh pathway in the hi

198 The reliable forward engineering of genetic systems remains limited by the ad hoc reuse of m

199 new DNA folds that will emerge in synthetic genetic systems replacing standard DNA and RNA as platfo

200 oteobacteria, and it is likely that the VtlR genetic system represents a common regulatory circuit cr

201 Natural and engineered genetic systems require the coordinated expression of pr

202 ective NK cell-mediated MCMV control in this genetic system required polymorphic H2k genes without ne

203 lts of minigenome assays and an EBOV reverse genetic system rescue support a role for both the panhan

204 We propose a genetic system, Semele, which may be used for both.

205 Molecular analyses of these simple genetic systems show rapid evolution, positive selection

206 ficiency aspects of this Junin virus reverse genetics system show great promise for addressing import

207 This suggests the possibility that other genetic system structures besides the natural one might

208 n pathogens, including NTHI, possess a novel genetic system, termed the phasevarion, which mediates a

209 ion in an exceptionally stable new four-base genetic system, termed xDNA, in which the base pairs wer

210 Here we report a Cre/loxP-based genetic system that allowed inducible deletion of specif

211 We previously developed a synthetic genetic system that allows a laboratory strain of Escher

212 sponse element, termed SILENCE, is a forward genetic system that allows for conditional, epigenetic c

213 nteraction, both important components of any genetic system that are often overlooked in association

214 A genetic system that contains more bits than the number t

215 Further, we developed a genetic system that enabled us for the first time to iso

216 nt genome-editing tools comprises a powerful genetic system that enables facile insertion and deletio

217 f yeast ribosomes were created using a yeast genetic system that enables stable production of ribosom

218 However, a genetic system that permits tracing the early events of

219 We expect that the tractable genetic system that we have developed will be useful for

220 Several genetic systems that allow the use of iron-protoporphyri

221 ts the development of specialized orthogonal genetic systems that could be evolved for novel function

222 they evolve to be critical components of the genetic systems that determine the biological diversity

223 owing that new genes rapidly change existing genetic systems that govern various molecular, cellular,

224 The genetic systems that initially suggested stress-induced

225 tors--are at the center of physiological and genetic systems that permitted the evolution of the huma

226 specificity of this response is conferred by genetic systems that restrict fusion to self and close k

227 ent after the development of the BTV reverse-genetics system that allows the introduction of targeted

228 first established a highly efficient reverse genetics system that increased rescue titers by >/=3 log

229 ction and may be applicable to other reverse genetics systems that rely on the introduction of severa

230 Using reverse genetics systems that we have recently developed, we hav

231 In several genetic systems, the speed of adaptation has been attrib

232 Compared to the classical reverse genetics system, the "eight-in-one" bacmids (bcmd-RGFlu)

233 capitulates a central aspect of an RNA-based genetic system: the RNA-catalyzed synthesis of an active

234 ults greatly extend the utility of the HCVcc genetic system to allow the complete in vitro and in viv

235 nsmitter to regulate locomotion, providing a genetic system to analyze serotonin signaling.

236 rosophila larvae, which represent a powerful genetic system to analyze the contribution of individual

237 Using fission yeast, we have developed a genetic system to block replication forks at nonhistone/

238 ed in other studies, we have developed a new genetic system to characterize ffs mutants.

239 Thus, C. elegans may be used as a genetic system to characterize novel cellular and molecu

240 eagues have further exploited the Drosophila genetic system to characterize two new phototransduction

241 We have developed a genetic system to conditionally misexpress Tbx2 in the e

242 Here, we describe a genetic system to conditionally reduce ATR expression to

243 We have made practical use of our genetic system to confirm that residues composing the ex

244 o demonstrates the usefulness of the reverse genetic system to confirm the role of residues or protei

245 hat are infectious in cell culture provide a genetic system to evaluate the significance of virus-hos

246 Here, we exploited the yeast genetic system to identify members of the mammalian AMPK

247 sophila adult midgut proves to be a powerful genetic system to identify novel mediators of APC phenot

248 model of tissue replacement that utilized a genetic system to identify transplanted cells and induce

249 In lieu of a functional genetic system to investigate floral development in thes

250 We have developed a genetic system to investigate the mechanisms of DNA doub

251 ation theory approach can be extended to any genetic system to predict new sites for DNA-binding prot

252 Dispensability provides an advantageous genetic system to probe the mechanisms of division prote

253 We have used a vaccinia virus-based reverse genetic system to produce recombinant viruses encoding n

254 Using a tripartite genetic system to selectively ablate either V1 or V2b IN

255 Using a chemical-genetic system to selectively and reversibly inhibit Zap

256 Herein, we deploy a genetic system to starve cells of an essential ribosomal

257 t stem cells may provide the necessary human genetic system to study germ cell development.

258 In an effort to develop a genetic system to study SifA function, we expressed SifA

259 Chlamydomonas reinhardtii provides a simple genetic system to study the role of the centriole in cil

260 pericarp and cob glumes, offers an excellent genetic system to study tissue-specific gene regulation.

261 In this study we used a genetic system to titrate the rate of GPCR signaling in

262 We have generated a novel genetic system to visualize cell lineages in living tiss

263 isms, we made use of the tet-On and Cre-loxP genetic systems to selectively and acutely express polyQ

264 We developed a reverse genetics system to create a mutant of RRV (RRV(VP4-R446G

265 ly efficient Rift Valley fever virus reverse genetics system to generate live recombinant viruses wit

266 dy, we employed a helper virus-based reverse genetics system to identify NSP2 gene regions that corre

267 nfirmed using a vaccinia virus-based reverse genetics system to produce a recombinant virus, Bristol

268 the United States, we established a reverse genetics system to produce infectious AMPV of subgroup C

269 We have developed a reverse genetics system to produce live recombinant PICV (strain

270 We established a reverse-genetics system to recover UUKV entirely from cDNA clone

271 cle (DISC) vaccine strain, we used a reverse genetics system to rescue defective virus strains with l

272 tablished a T7 RNA polymerase-driven reverse genetics system to rescue infectious clones of RVFV MP-1

273 A reverse genetics system to rescue infectious Lujo virus from cDN

274 port the development of an efficient reverse genetics system to rescue recombinant LASV and to invest

275 tch in vitro, we first established a reverse genetics system to rescue UUKV with a genome close to th

276 Therefore, the use of reverse genetics systems to engineer viruses lacking NSs is an a

277 Here we report the development of reverse genetics systems to study STFSV replication and pathogen

278 This ZIKV reverse genetic system, together with mouse and mosquito infecti

279 A genetic system utilizing alkaline phosphatase secretion

280 In this study, a genetic system was developed for M. sedula to investigat

281 A genetic system was developed for MLHE-1 and used to show

282 nt lines of evidence suggest that the modern genetic system was preceded by the 'RNA world' in which

283 A reverse genetic system was recently established for the coronavi

284 A reassortment-based viral genetic system was used to map transmissibility by thrip

285 The reverse genetics system was used to analyze the role of the clea

286 Moreover, the reverse genetics system we constructed will be helpful for study

287 king dendrite structure and function in this genetic system, we analyzed da neuron axon projections i

288 Using a novel genetic system, we demonstrated that seven of the nine g

289 nces of G4C2 repeat expansion in a tractable genetic system, we generated transgenic fly lines expres

290 Using the Pichinde virus (PICV) reverse genetics system, we analyzed the effects of alanine subs

291 Using an IBV reverse genetics system, we demonstrated that the template-switc

292 Using the SARS-CoV reverse genetics system, we generated and characterized a chimer

293 Using a reverse genetics system, we generated recombinant RSV (rRSV) con

294 By using the reverse-genetics system, we identified that 4 amino acid substit

295 Using the eight-plasmid reverse genetics system, we rescued wild-type SIV A/swine/Minnes

296 ults indicate that the BAC-based MHV reverse genetics system will be useful for studies of JHMV and e

297 This optimized henipavirus reverse genetics system will facilitate future investigations in

298 that the combination of a synthetic modular genetic system with fluorescence correlation spectroscop

299 llespie's results are extended to population genetic systems with explicit age structure, where the d

300 ted substitutions is an emergent property of genetic systems with implications for evolution, vaccine