ライフサイエンスコーパス: genetic variability

1 of genetic plasticity underlying transverse genetic variability.

2 of congenital infection, exhibits extensive genetic variability.

3 robustness in the face of environmental and genetic variability.

4 different growth conditions and/or inherent genetic variability.

5 s, and managed-breeding strategies to retain genetic variability.

6 ing breeding populations for repositories of genetic variability.

7 y by shared environmental factors and not by genetic variability.

8 This indicates a large degree of genetic variability.

9 f the viral genome and are a major source of genetic variability.

10 contribution of different marked effects to genetic variability.

11 while the American C. dentata had the lowest genetic variability.

12 ross loci, may also lead to heterogeneity of genetic variability.

13 ogy, vascular and metabolic risk factors and genetic variability.

14 are often driven by mechanisms that promote genetic variability.

15 history that continue to influence levels of genetic variability.

16 ructure, extensive glycosylation, and marked genetic variability.

17 es, at least at the scale of intrapopulation genetic variability.

18 rbations of cellular function and individual genetic variability.

19 sulate development against environmental and genetic variability.

20 ctions in both the number of individuals and genetic variability.

21 s6466849, rs10268496) that cover all TAS2R16 genetic variability.

22 s, differential pathological signatures, and genetic variability.

23 de immune detection and/or exhibit extensive genetic variability.

24 Naturally occurring genetic variability across HIV-1 subtypes causes amino a

25 esponsible for heterogeneity of the level of genetic variability across loci.

26 t differences in copy number are a source of genetic variability among D. v. virgifera.

27 To evaluate genetic variability among Entamoeba histolytica strains,

28 en deposition in the heart by exploiting the genetic variability among F2 progeny of 129P2 and FVBN/J

29 (cytb), were analysed in silico to identify genetic variability among the four species and used, sub

30 drial COI regions have been used to estimate genetic variabilities and reconstruct phylogenies.

31 l systems can serve as the interface between genetic variability and alterations in complex behaviora

32 stributions of offspring number on levels of genetic variability and among-population differentiation

33 ntifying its modulation by crop N status and genetic variability and analyzing its ecophysiological d

34 The reduced genetic variability and apparent gene deletion in some r

35 by examining the relationship between common genetic variability and brain endophenotype.

36 Our data highlight the genetic variability and capacity in causing outbreak by

37 The genetic variability and covalent modifications associate

38 the ISR was used to determine the worldwide genetic variability and distribution of P. gingivalis, a

39 Despite its high prevalence, the genetic variability and drug resistance characteristics

40 rstanding of such fauna is limited and their genetic variability and evolutionary origins remain poor

41 In this study, we determined levels of genetic variability and gene flow among seven population

42 A fine balance between genetic variability and genomic stability tunes plastici

43 The Italian and Iberian populations have low genetic variability and high linkage disequilibrium, but

44 Simplot was used to compare genetic variability and high-speed sequencing was used t

45 The strong associations between IL6R genetic variability and IL-6 concentrations deserve furt

46 Stable naive hPSCs with reduced genetic variability and improved functional pluripotency

47 sts that these differences can contribute to genetic variability and pathologic susceptibility.

48 deficiency virus type 1 (HIV-1), we analyzed genetic variability and PI resistance-associated substit

49 s with maladaptive gene flow or by enhancing genetic variability and reducing inbreeding depression,

50 wever, European populations showed a loss of genetic variability and significant genetic differentiat

51 As diverse agents of selection shape genetic variability and structure within species, we arg

52 constitutes a substantial fraction of total genetic variability and the importance of structural gen

53 d suggest a potential mechanism between MAPT genetic variability and the pathogenesis of neurodegener

54 ld will yield data that can account for both genetic variability and the role of critical development

55 arked effects within chromosomes, background genetic variability, and family heterogeneity.

56 Current genetic variability, and inferred past demographic chang

57 multistep nature of viral oncogenesis, host genetic variability, and the fact that viruses contribut

58 oup of scientists expert in the field of HCV genetic variability, and those involved in development o

59 In species whose distribution and genetic variability are shaped by strong selection gradi

60 e the potential to show and emphasise common genetic variability associated with disease.

61 Here, we examine the levels of genetic variability at 13 (seven informative) loci in wi

62 ations (FST > 0.130) and discovered temporal genetic variability at a single site that was on par wit

63 , we examined the association between LP and genetic variability at candidate regulatory regions in 5

64 Notably, by Shannon entropy, higher genetic variability at HBsAg amino acid positions 130, 1

65 ucleotide polymorphisms and found widespread genetic variability at many of these loci.

66 ine the signature of population expansion on genetic variability at microsatellite loci, we consider

67 Our findings point to genetic variability at the ADIPOR1 locus as a strong det

68 Genetic variability at the APOA1/C3/A4/A5 cluster has be

69 Additionally, we show that individual genetic variability at the Apobec1 locus results in diff

70 n polymorphisms comprehensively defining the genetic variability at the IL6 locus with diabetes risk.

71 Extensive population-level genetic variability at the Salmonella rfb locus, which e

72 of all these diseases are predisposed to by genetic variability at the same loci, strongly suggestin

73 We investigated whether genetic variability at this locus is a determinant of fr

74 In the pooled sample, genetic variability at this locus was associated with di

75 ction with other recent studies showing that genetic variability at this same locus are related to ch

76 There was substantial genetic variability between clinical and laboratory isol

77 The genetic variability between phenotypically distinct stra

78 Additional genetic variability between the seven B. subtilis 168 is

79 ive hybridization was employed to assess the genetic variability between two distinct clinical isolat

80 group A and group B RS viruses demonstrated genetic variability between years and within individual

81 the two primary threats are slow erosion of genetic variability by drift and short-term lowering of

82 However, female choice can actually increase genetic variability by supporting a higher mutation rate

83 This study demonstrates that genetic variability can affect the outcome of cardiac su

84 Moreover, they show that intraspecific genetic variability can be as important as strong trophi

85 With maternal selection, genetic variability can be maintained in the population

86 practice based on these recent discoveries, genetic variability clearly appears to affect pain perce

87 e Yellowstone grizzly bear has low levels of genetic variability compared with other Ursus arctos pop

88 The observed interactions between genetic variability, CVRFs, and MPV and its association

89 ence of a single genome does not reflect how genetic variability drives pathogenesis within a bacteri

90 rstly, it is responsible for the creation of genetic variability during meiosis by directing the form

91 kely to be responsible for the generation of genetic variability, even within inbred lines.

92 We sought to identify any common genetic variability exerting a large effect in risk for

93 We aimed to identify any common genetic variability exerting a moderate to large effect

94 Genotyping studies suggest that genetic variability exists among P. gingivalis strains;

95 According to the genetic variability for carotenoids and tocochromanols,

96 ried widely and the genotypes presented high genetic variability for carotenoids and tocochromanols.

97 eders have increased the yield of this crop, genetic variability for conductance has allowed inadvert

98 lymorphisms to explore the full dimension of genetic variability for future cattle genomic research.

99 y a role in the expression of phenotypic and genetic variability for subsequent selection and evoluti

100 become ineffective owing to loss of additive genetic variability for the preferred traits.

101 likely than nonmutator phenotypes to acquire genetic variability from a more diverged set of donor ba

102 Extensive genetic variability, generally in gp120 and the gp41 ect

103 These data show that common genetic variability has a role in the disease.

104 Vascular endothelial growth factor (VEGF) genetic variability has been associated with altered ris

105 how genome structure and pathogen population genetic variability has been shaped by transposable elem

106 uman brain, because tools for assessing this genetic variability have not been available.

107 rames encode enzymes which may contribute to genetic variability, i.e., restriction-modification syst

108 dies have provided information on how common genetic variability impacts on the risk for the developm

109 f GRN is regulated by miRNAs and that common genetic variability in a miRNA binding-site can signific

110 These results suggest that the amount of genetic variability in a population may be an important

111 strongest in Parkinson's disease (PD), where genetic variability in alpha-synuclein expression affect

112 s to hypothesize that it might contribute to genetic variability in ASFV.

113 Our data show that there is genetic variability in beta-carotene metabolism and may

114 In summary, the distribution of genetic variability in C. quercuum fusiforme is consiste

115 ng, the molecular mechanism(s) through which genetic variability in Chrna7 may contribute to alpha7 n

116 eristics of the virus, including the extreme genetic variability in circulating viral isolates worldw

117 We propose a model where ASE requires genetic variability in cis, a difference in the sequence

118 herapy and suggest that detailed analysis of genetic variability in clinical trial cohorts can lead t

119 Thus, genetic variability in CTGF expression directly modulate

120 on wound biology has shown the importance of genetic variability in determining the initial inflammat

121 Genetic variability in DNM3 modifies age of onset for LR

122 rait loci (QTLs) were detected that underlay genetic variability in En Interestingly, four of them co

123 can be used as surrogate markers and whether genetic variability in germline ERBB2 (formerly HER2 or

124 trend, as well as the likely high degree of genetic variability in heat tolerance, suggests that mor

125 Despite this, there has been little work on genetic variability in human gene expression and almost

126 Recent claims that patterns of genetic variability in human mitochondria show evidence

127 Patterns of genetic variability in human populations are profoundly

128 humans and the mechanisms of maintenance of genetic variability in human populations, and for detect

129 background of myelination, the clinical and genetic variability in hypomyelinating leukodystrophies,

130 strate specific and differential patterns of genetic variability in inhibition of sucrose intake by d

131 ) are believed to contribute strongly to the genetic variability in living beings, in particular thei

132 Statistical analysis of the genetic variability in mammary tumor latency indicated t

133 ence studies generally confirm the extensive genetic variability in modern maize is consistent with a

134 been an abundance of publications describing genetic variability in molecules relevant to transplant

135 he concomitant use of other drugs and common genetic variability in monoamine regulation present addi

136 e gene content, functional significance, and genetic variability in natural microbial communities.

137 polysaccharides) of triticale as well as the genetic variability in nutritional composition have been

138 These data indicate the importance of genetic variability in opioid modulation of sucrose inta

139 orphisms (tSNPs) accounting for > 92% of the genetic variability in PLA2G2A were identified and disti

140 ain the incidence of secondary infection and genetic variability in populations containing or lacking

141 natural selection has resulted in high CD36 genetic variability in populations of African descent.

142 relatively unbiased picture of the extent of genetic variability in protein sequences within populati

143 nts, platelet dysfunction can be a result of genetic variability in proteins that mediate inside-out

144 The molecular mechanisms that mediate genetic variability in response to alcohol are unclear.

145 Although recombination is a major source of genetic variability in retroviruses, no recombinant stra

146 been underway to control this parasite, but genetic variability in S. japonicum populations could re

147 uman EPHX2 mutations may in part explain the genetic variability in sensitivity to ischemic brain inj

148 for previously reported associations between genetic variability in serotonin transporter function an

149 f hypervariable genes can negate the lack of genetic variability in species such as B. anthracis and

150 Our analyses demonstrate that genetic variability in the alpha-synuclein gene is a ris

151 Therefore, genetic variability in the alpha2-macroglobulin gene is

152 Escherichia coli pathotypes reveal extensive genetic variability in the argW-dsdCXA island.

153 Genetic variability in the behavioral responses of exper

154 d the presence of the hmuR gene and revealed genetic variability in the carboxy terminus of hmuR in P

155 Together, these data indicate that genetic variability in the CRP gene is associated with s

156 We conclude that genetic variability in the HNF-4gamma gene is unlikely t

157 rs in mice reveal an important potential for genetic variability in the imprinting process, and also

158 s novel insight into the association between genetic variability in the leptin gene and anemia in HIV

159 suggested that in many neurological diseases genetic variability in the loci predisposing subjects to

160 Examination of the role of genetic variability in the long-term evolution of clades

161 c sequencing to evaluate the contribution of genetic variability in the pathogenesis of amyotrophic l

162 o warfarin was more strongly associated with genetic variability in the pharmacologic target of warfa

163 idea that they may serve as a reservoir for genetic variability in the PKD1 gene.

164 The observed significant genetic variability in the response of wheat to heat str

165 While the limited genetic variability in these animals prevents us from ma

166 Here, we show that genetic variability in these regions can be explained by

167 Investigation of the effects of genetic variability in this gene on brain function could

168 s studies have targeted the contributions of genetic variability in this system to human brain activi

169 However, the contributions of genetic variability in this system to individuals' cogni

170 pulsed characters and the expected level of genetic variability in those control variables.

171 eflect an inducible mechanism that generates genetic variability in times of stress.

172 hese studies emphasize the potential role of genetic variability in transplantation, and provide the

173 exome, and Sanger sequencing to analyze the genetic variability in TREM2 in a series of 1092 patient

174 at genome size is negatively correlated with genetic variability, independent of phylogeny, body size

175 Genetic variability influences susceptibility to the pot

176 tions have been made that would suggest that genetic variability influencing allograft survival reach

177 controlled breeding practices has segregated genetic variability into distinct dog breeds that posses

178 Genetic variability is a hallmark of RNA virus populatio

179 used to detect biological pathways in which genetic variability is associated to variation in gene e

180 nding-oligomerization domain function due to genetic variability is associated with an increased susc

181 Therefore, knowledge of its DNA genome and genetic variability is central to preventing and treatin

182 ng individual organisms of which significant genetic variability is displayed.

183 a strongly discontinuous model for how human genetic variability is distributed and shows how individ

184 We hypothesized that this genetic variability is driven by immune selection pressu

185 eletions (<1Kb), a significant proportion of genetic variability is due to copy number variation (CNV

186 Although genetic variability is known to greatly impact on the hu

187 bjected to regulation by naturally occurring genetic variability is of relevance for the understandin

188 accelerate bacterial adaptation when desired genetic variability is present within DNA fragments of u

189 or chaperone function in the context of high genetic variability is proposed.

190 lity and disease, and have shown that common genetic variability is unlikely to explain the entire ge

191 ene copy number variation, a major source of genetic variability, is important for several genes that

192 iduals extinguish conditioned fears, such as genetic variability, learning capacity and conditions un

193 is issue of Neuron, Cruchaga et al. identify genetic variability linked to altered levels of tau prot

194 Such genetic variability may be important for ACVr disease in

195 Host genetic variability may contribute to susceptibility of

196 is reasonable to expect that a wide range of genetic variability may exist given all of the different

197 Although a high rate of genetic variability may facilitate viral escape and pers

198 activity based on drug-drug interactions or genetic variability may therefore influence glibenclamid

199 olerance to various stresses and loss of the genetic variability needed to correct that.

200 E on the offspring appear to be moderated by genetic variability, neurobehavioral disinhibition, and

201 t a single site that was on par with spatial genetic variability observed over distances of 15,000 km

202 ery little is known about the occurrence and genetic variability of (pro)phages within the Bifidobact

203 ty of a phiKMVvirus to dramatically increase genetic variability of a co-infecting phage), highlighti

204 ed by functional studies and analysis of the genetic variability of AGER in patients with CF.

205 specific drugs a nd vaccines is the study of genetic variability of allpublicly available HCV sequenc

206 Almost all theories for the genetic variability of characters assume measurements on

207 Here we report on the genetic variability of comC and comD within Streptococcu

208 e phenotypic and mutational spectrum and the genetic variability of DNAJC3, we analyzed 8,603 exomes,

209 ak similarities in many cases, suggestive of genetic variability of erp genes among these bacteria.

210 We further estimated the genetic variability of gut microbes, with Bacteroides sp

211 mers or probe mismatches related to the high genetic variability of HDV and, possibly, to the complex

212 tudy this question making use of the natural genetic variability of human populations, which allows u

213 The host genetic variability of immune response to HIV and immune

214 viruses was used to assess the impact of the genetic variability of influenza A(H3N2) viruses on infl

215 butes in phenotypically relevant ways to the genetic variability of many organisms.

216 ructures of recently evolved halophytes, the genetic variability of model plants, and endemic halophy

217 s result is mirrored by field surveys of the genetic variability of natural strains of yeast.

218 The genetic variability of nine genes in 12 isolates and str

219 Assessing the genetic variability of plant performance under heat and

220 Genetic variability of Plasmodium falciparum underlies i

221 We assessed the impact of the whole common genetic variability of PROX1 (80 SNPs) on type 2 diabete

222 rapies and vaccines that may bypass the wide genetic variability of RNA viruses.

223 Here, we characterized the genetic variability of RSV during 5 seasons, and evaluat

224 eport, for the first time, we associated the genetic variability of SCN4A with the development of ess

225 Overall, our data reveal that the genetic variability of Seg-10/NS3 differentially modulat

226 The genetic variability of SIVsm strains among PCs may influ

227 r account for only a small proportion of the genetic variability of tested diseases.

228 The genetic variability of the ADIPOQ gene and circulating a

229 The differential regulation and genetic variability of the ALS genes results in a divers

230 Here we show that genetic variability of the gene encoding PKCalpha (PRKCA

231 We also predicted that genetic variability of the genes conferring resistance t

232 nderstanding of the population structure and genetic variability of the genus Mycobacterium, we condu

233 Because of the genetic variability of the HIV-1 envelope glycoproteins

234 Genetic variability of the host may have large impact on

235 erogeneous disease such as HCM with the vast genetic variability of the human genome, and high freque

236 For example, genetic variability of the mu-opioid receptor (MOR)-enco

237 The present study examined the genetic variability of the PePHD in patients receiving I

238 Genetic variability of the PFam54 gene array suggests th

239 tion of the disease may be influenced by the genetic variability of the plcD region.

240 Levels and genetic variability of the PON1 position 192 isoforms (G

241 Our study revealed high genetic variability of the S. epidermidis genome, new ma

242 this study, we focused our attention on the genetic variability of the TAS2R16 gene, encoding for on

243 (RSV) within communities may result from the genetic variability of the virus and associated evolutio

244 cine will need to overcome the extraordinary genetic variability of the virus, where most variation o

245 accomplishing these goals is the tremendous genetic variability of the virus, with some genes differ

246 The genetic variability of these isolates within phylogeneti

247 ium; however, the prevalence, expression and genetic variability of this protein in native marine mic

248 A multilocus genetic score reflecting genetic variability of this signature is associated with

249 on mutations within rdxA, possibly revealing genetic variability of this trait in C. jejuni due to sp

250 nown regarding the generation and effects of genetic variability of virus replication in the natural

251 used on epidemiological investigation of the genetic variability of well-documented strains of Y. pes

252 associated with GRN haploinsufficiency, and genetic variability on the wild-type GRN allele might ha

253 her evidence of the important role that host genetic variability plays in the determination of diseas

254 Genetic variability, population structure and gene flow

255 To better understand the genetic variability present among pediatric strains and

256 The remarkable genetic variability present within the species is reflec

257 Single-clone algal cultures (lacking genetic variability) produced short cycle periods and ty

258 known to be metabolized by enzymes with this genetic variability (range, P =.006-P<.001).

259 In worldwide populations, SNCA genetic variability remains the most reproducible risk f

260 targets contribute significantly to the non-genetic variability seen within and across individuals,

261 rvival of Egfrtm1Mag homozygous embryos, the genetic variability segregating within the outbred popul

262 Our findings establish that genetic variability, smoking, and COPD all influence CST

263 The low genetic variability suggests that evolutionary pressure

264 which species are able to retain more useful genetic variability than they 'should', for example by e

265 d may serve as a mechanism for meningococcal genetic variability that avoids the fitness costs encoun

266 is circuitry may arise, in part, from common genetic variability that contributes to risk for MDD.

267 ed to use a genome-wide approach to identify genetic variability that directly affects LRRK2 Gly2019S

268 Recent work has emphasised the marked genetic variability that exists in the Fc receptor locus

269 In view of the pronounced antigenic and genetic variability that has been noted in the Osps of o

270 valuable in providing new insights into the genetic variability that is present in a particular spec

271 Potential sources of genetic variability that may contribute to the disorder'

272 is driven by the advantages conferred by the genetic variability that results from transposition, in

273 nted by other researchers to identify common genetic variability that results in minor and moderate r

274 characterized by significant phenotypic and genetic variability the genetic matrix has a strong infl

275 sis; the classical vs balance hypothesis for genetic variability; the neutral theory of molecular evo

276 t transformation, but limitations imposed by genetic variability, tumor heterogeneity, availability o

277 ears offered a unique opportunity to examine genetic variability under natural conditions.

278 Knowledge of genetic variability underlying drug resistance and other

279 selection, which is predicted to reduce the genetic variability underlying such traits.

280 Genetic variability was also assessed, for sister pairs

281 Although some genetic variability was detected among the five isolates

282 High genetic variability was found for En under both scenario

283 Genetic variability was measured in terms of polymorphis

284 The role of genetic variability was tested by comparing triploids ge

285 0 sequences from various BTV strains display genetic variability, we assessed the impact of different

286 Despite genetic variability, we found no difference in the sever

287 SNPs genotypes, explaining >92% of the locus genetic variability, were determined in 519 patients wit

288 he weight given to within- and between-breed genetic variability, were used in order to estimate the

289 xpansive growth to water deficit has a large genetic variability, which is higher than that of photos

290 inese chestnut C. mollissima had the highest genetic variability, while the American C. dentata had t

291 into the mechanistic and network effects of genetic variability, with improved statistical power to

292 opulations in T-705-treated mice had greater genetic variability, with more frequent transversion eve

293 y is reflected in substantial ecological and genetic variability within and among Trichinella taxa, a

294 mapping within the linkage region suggested genetic variability within DNM3 as an age-of-onset modif

295 The selected plants were cloned to reduce genetic variability within each genotype.

296 d comparative genomics provides a measure of genetic variability within natural populations and ident

297 The study of genetic variability within natural populations of pathog

298 Genetic variability within populations was high relative

299 TFV is a substrate for ABCC10, and genetic variability within the ABCC10 gene may influence

300 Genetic variability within the groups was assessed by re