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1 trol before establishing acquired resistance genetically.
2  samples were closely related to one another genetically.
3 of patients with CIDs in Iran clinically and genetically.
4 t, Fogarty et al. (2017) used CRISPR/Cas9 to genetically ablate the OCT4 gene in human preimplantatio
5                                              Genetically ablating these neurons in juveniles disrupte
6 irst examples of serially transplantable and genetically accurate models of CMML.
7 leukemic cells in vivo, allowing creation of genetically accurate preclinical models of these disorde
8                                              Genetically admixed populations that speak creole langua
9 tion of O-GlcNAcylation pharmacologically or genetically aggravates the ischemia-induced brain damage
10           Using T cell-specific murine lines genetically altered in expression of p38alpha, and mice
11                   Testing this hypothesis in genetically altered mice showed that the corresponding a
12     The interleukin-23 pathway is implicated genetically and biologically in the pathogenesis of Croh
13 e has a discrete pathophysiology and differs genetically and clinically from recessive Wolfram syndro
14 OTU, BU, and EB represent discrete lineages, genetically and developmentally specified sets of cells
15 n is structurally conserved with the Gn of a genetically and geographically distal hantavirus, Puumal
16                 We probed these interactions genetically and identified second-site suppressors of le
17 om a common ancestor are expected to diverge genetically and phenotypically as they adapt to differen
18                                        MM is genetically and phenotypically heterogeneous, so targeti
19                       This approach provides genetically and spatially targetable, repeatable and tem
20 islet or celiac disease (CD) autoimmunity in genetically at-risk children prospectively followed up f
21 , one of the most promising candidates for a genetically attenuated vaccine against malaria (5) , as
22 (mES) cell lines targeting 16,970 genes with genetically barcoded, conditional and reversible mutatio
23 pal causal interactions between the primary, genetically based organic processes of evolution and the
24 editary NS and 5 (5%) patients with probably genetically caused NS.
25 = 3 x 10(-3)), suggesting a path forward for genetically characterizing more complex cases of autism.
26 ted macular degeneration (AMD), a common and genetically complex disorder, which can lead to misdiagn
27 te that GWAS of single heritable features of genetically complex disorders followed by chromosome con
28 38% of the risk, suggesting that MPB is less genetically complex than other complex traits.
29 tion for which 30% of patients are without a genetically confirmed diagnosis.
30                            The prevalence of genetically confirmed FH was 8.7% (95% confidence interv
31 o diagnose 4 (44%) and 3 (33%) patients with genetically confirmed FH, respectively.
32 an in his 70s with a longstanding history of genetically confirmed HCM presented with rapid developme
33 re assessed in patients aged 3-25 years with genetically confirmed type 2 or non-ambulatory type 3 SM
34                                 In contrast, genetically corrected ESCs differentiated to CD4 + or CD
35                            As a consequence, genetically corrected HSC-derived macrophages were able
36                           Transplantation of genetically corrected HSCs into Ifngammar1(-/-) mice bef
37 rating that distinct cognitive abilities are genetically correlated and thus share a biological subst
38 te at the first position) were significantly genetically correlated with all the T2D-related traits.
39                                           We genetically cross two lethal parasites with distinct dis
40 n is a major driver of the transformation of genetically defective liver stem cells (LSCs) into highl
41 izure disorder, kidney disease duration, and genetically defined ancestry.
42          Together with new observations from genetically defined autism risk alleles and rodent model
43  initially developed for profiling mRNA from genetically defined cell types in complex tissues.
44                                           In genetically defined mouse models, studies of postnatal s
45  in neuroscience that enable the analysis of genetically defined neuronal circuits with unprecedented
46 senting a tethered ligand at the synapses of genetically defined neurons, thereby activating the path
47  then validated on a commercially available, genetically defined PD-L1 engineered cell line array wit
48 examined how the anatomical composition of a genetically defined population of balance interneurons i
49 , and discovered a new behavioral role for a genetically defined population of central vestibular neu
50 dentification of proteins from spatially and genetically defined regions of the brain.
51 eviously untreated, clinically-annotated and genetically-defined high grade gliomas.
52                                     Here, we genetically deleted Srebf-2 from hepatocytes and confirm
53 ssion of FLOWERING LOCUS T This phenotype is genetically dependent on CO.
54 supplements or fuels; thus, a feedstock with genetically designed and tunable degree of unsaturation
55 junction cardiomyopathy, typically caused by genetically determined abnormalities of cardiac desmosom
56                                              Genetically determined accessibility was enriched at dis
57 ning reflects the influence of experience on genetically determined circuitry, but little is known ab
58                   These results suggest that genetically determined Cp levels can alter susceptibilit
59  affect the epigenome and potentially rescue genetically determined disease phenotypes.
60                      An increase of 10 cm in genetically determined height was associated with increa
61 ts were initially referred with suspicion of genetically determined hypertrophic cardiomyopathy.
62 e interaction between parasite virulence and genetically determined levels of host-plant resistance a
63 hese findings strengthen the hypothesis that genetically determined local dysregulation of dietary vi
64                 To examine whether HCV has a genetically determined lymphotropism through a co-recept
65                  Mitochondrial disorders are genetically determined metabolic diseases due to a bioch
66                                     GSS is a genetically determined TSE caused by a range of mutation
67          Although its properties are in part genetically determined, altered light-dark environment c
68                      Oxetane grafting of the genetically detoxified diphtheria toxin CRM197 improves
69 nerates a spectrum of genome diversity(8) or genetically discrete populations(9,10).
70 lic modeling approach was developed using 19 genetically distant maize (Zea mays) lines from Europe a
71    Mixed lineage leukemia (MLL) represents a genetically distinct and aggressive subset of human acut
72 th timing of reproduction are shared between genetically distinct and geographically distant populati
73  WGS identified 1 or more isolates that were genetically distinct despite having the outbreak pulsed-
74 idespread cis variation in RNA editing among genetically distinct individuals and sheds light on poss
75 nvironmental toxicants differentially affect genetically distinct individuals, but the mechanisms con
76  recurrence, and (3) multifocal disease with genetically distinct lesions.
77          Mediterranean fin whales comprise a genetically distinct population, listed as Vulnerable (V
78 esocosms originating from geographically and genetically distinct populations in Switzerland.
79                    Here, we identify several genetically distinct populations of CeA neurons that med
80  that patients with MCC may develop a second genetically distinct primary tumor; in this case, the su
81               Cases 1 and 4 were verified as genetically distinct primary tumors and did not harbor s
82               The development of multifocal, genetically distinct tumours is suggestive of a field de
83 arentally, often without recombination among genetically divergent organelles.
84 cell wall polysaccharides collected from 331 genetically diverse Brassica napus cultivars and used th
85                                              Genetically diverse groups produced root litter that had
86 observed in soil conditioned by siblings and genetically diverse groups.
87 cer profiling of a cohort of more than forty genetically diverse human colorectal cancer (CRC) specim
88 er predict and optimize humoral responses in genetically diverse human populations, with immediate im
89        Preexisting cross-reactive T cells to genetically diverse IAV strains were found in the majori
90 sting, cross-reactive T cells in children to genetically diverse influenza A virus (IAV) strains to w
91                  Bacteria represent the most genetically diverse kingdom of life.
92                          Significantly, less genetically diverse mangrove species suffered much great
93                 Here, we leveraged a unique, genetically diverse population of C. neoformans from sub
94            Within their hosts, they exist as genetically diverse populations (i.e., viral mutant swar
95 t adaptation if the founders originated from genetically diverse populations.
96 distinct disease phenotypes, and identify 43 genetically diverse progeny by typing with microsatellit
97  is conserved not only during infection with genetically diverse Toxoplasma strains but also with Neo
98 annoside, reduces intestinal colonization of genetically diverse UPEC isolates, while simultaneously
99                 The muscular dystrophies are genetically diverse.
100       Susceptibility to infection is in part genetically driven, and C57BL/6 mice resist various path
101                                              Genetically elevated circulating levels of C-reactive pr
102                               The ability to genetically encode an expanded set of building blocks wi
103                     Here we describe DeActs, genetically encoded actin-modifying polypeptides, which
104                    Bacterial cell shape is a genetically encoded and inherited feature that is optimi
105  with sensitivity surpassing those of purely genetically encoded approaches.
106 n-canonical amino acid coumarin-tyrosine was genetically encoded at Y671, a residue proximal to the s
107 siological studies, we developed a sensitive genetically encoded bilirubin (BR)-inducible fluorescenc
108                                        Using genetically encoded Ca(2+) sensors, we found that mitoch
109                                    We used a genetically encoded calcium indicator and readily detect
110 ng in vivo two-color two-photon imaging with genetically encoded calcium indicators, we demonstrate t
111 , we developed an alternative approach using genetically encoded chemical tags CLIP, SNAP, Halo, and
112 or sensing EGFR activity in cells, we used a genetically encoded CrkII-based biosensor which undergoe
113                       To address this gap, a genetically encoded cyclic peptide was designed based on
114                Utilizing a novel ratiometric genetically encoded cytosolic Ca(2+) indicator, Salsa6f,
115                           We developed novel genetically encoded ER-targeted low-affinity Ca(2+) indi
116 esponses of individual osteocytes by using a genetically encoded fluorescent Ca(2+) indicator.
117             We describe the development of a genetically encoded fluorescent tRNA fusion with the pot
118 e high spatiotemporal resolution afforded by genetically encoded Forster resonance energy transfer (F
119                                    We used a genetically encoded high throughput screening platform t
120 increases thermotolerance in addition to the genetically encoded HSR.
121 lta,-dehydrolysine, an allysine precursor is genetically encoded in E. coli.
122                                   The use of genetically encoded noncanonical amino acids (ncAAs) to
123                                          The genetically encoded photo-cross-linkers promise to offer
124 ery, evolution and generalization of a fully genetically encoded platform for producing chiral organo
125                         To this end, we used genetically encoded probes consisting of the PtdIns4P-bi
126                                              Genetically encoded sensors based on fluorescence resona
127 for the "assembly line" biosynthesis of many genetically encoded small molecules.
128 alamin binding domain (CarHC) proteins using genetically encoded SpyTag-SpyCatcher chemistry under mi
129                           We have previously genetically encoded the noncanonical amino acid 5-hydrox
130                                              Genetically encoded voltage indicators create an opportu
131                         In particular, while genetically encoded voltage indicators have shown promis
132 e capability to resolve the responses of two genetically encoded Zn(2+) sensors at a range of time po
133                                        Using genetically-encoded, site-specific incorporation of unna
134                                           By genetically encoding this sensor in the human malarial p
135 AM composition during gliomagenesis, we used genetically engineered and GL261-induced mouse models in
136 o create biosynthetic excitable tissues from genetically engineered and immortalized HEK293 cells wit
137 ly attach disease-associated autoantigens to genetically engineered and to unmodified red blood cells
138  Here, we used cells from human tumors and a genetically engineered autochthonous mouse model of soft
139 elastomer hybrids that host various types of genetically engineered bacterial cells.
140 en globally used in basic plant research and genetically engineered crops (1-4) .
141 rence in pHCA production yield between three genetically engineered E. coli strains was successfully
142                             Serratia AS1 was genetically engineered for secretion of anti-Plasmodium
143                                              Genetically engineered mice, with human P2X7R, revealed
144 d-test" cycle paradigm, massive libraries of genetically engineered microbes can be constructed and t
145 value-added chemicals.Screening libraries of genetically engineered microbes for secreted products is
146 ine resistance by utilizing tissues from the genetically engineered mouse model and human pancreatic
147                     Sensory denervation of a genetically engineered mouse model of PDAC led to loss o
148          To visualize TRPV1-lineage axons, a genetically engineered mouse model was used in which a f
149                    Preclinical studies using genetically engineered mouse models (GEMM) have the pote
150 can be achieved using organoids derived from genetically engineered mouse models (GEMMs), wild-type o
151 n KRAS mutant tumors has been established in genetically engineered mouse models and human tumor cell
152                                      In both genetically engineered mouse models and murine xenograft
153                                      We used genetically engineered mouse models of glioma and quanti
154     Loss of EphA2 function in both human and genetically engineered mouse models of TNBC reduced tumo
155                                              Genetically engineered mouse models that employ site-spe
156                             In xenograft and genetically engineered mouse models, the WDR4/PML axis e
157  against skin carcinogenesis was examined in genetically engineered mouse models.
158 s, fluctuations are typically assessed using genetically engineered reporter cell lines that produce
159                                              Genetically engineered T cells are powerful new medicine
160 iet (HFD) induced diabetic mouse model and a genetically engineered T2DM rat model.
161  infusion of bone marrow-derived macrophages genetically engineered to overexpress murine MCAD marked
162 ute a single factor, both phenotypically and genetically, even after controlling for g This spatial a
163  truncated version of flagellin (NtCFlg) was genetically fused to the N- or C-terminus of Bet v 1.
164 ic male-male courtship and indicate that the genetically hard-wired neural mechanisms enforcing behav
165                                     HGF is a genetically heterogeneous disorder and can be transmitte
166 llectual disability (ID) is a clinically and genetically heterogeneous disorder, affecting 1-3% of th
167 mocytomas and paragangliomas are infrequent, genetically heterogeneous neuroendocrine tumors.
168 rome (HLHS), a severe CHD, is multigenic and genetically heterogeneous.
169  that FTD is clinically, pathologically, and genetically heterogeneous.
170  SHFYNG syndromes, and confirms that OTCS is genetically heterogeneous.
171 Congenital myopathies are phenotypically and genetically heterogeneous.
172  To clarify, we assessed whether people with genetically higher calcium had a higher risk of coronary
173 growing bacterium typically divides into two genetically identical and morphologically similar sister
174 has gained popularity as a method to produce genetically identical animals or superior animals for re
175                                              Genetically identical cells frequently display substanti
176 The quiescence-exit process is noisy even in genetically identical cells under the same environmental
177     Quiescence exit is highly noisy even for genetically identical cells under the same environmental
178 rsistent gastrointestinal carriage states in genetically identical mice.
179 lations of bacilli can survive despite being genetically identical to those that are easily killed.
180 symptoms in a sample of N = 100 monozygotic (genetically identical), adolescent twins.
181 that differ in life-history strategy but are genetically identical.
182  manipulations and trans-synaptic tracing of genetically identified dorsal horn and RVM neurons to un
183                         Using CRISPR/Cas9 to genetically inactivate a TWIST2 orthologue, we suppresse
184 sed at these inhibitory synapses and must be genetically inactivated together with Syt2 to achieve a
185 hese different lifestyles occur in separate, genetically incompatible species.
186                                    Moreover, genetically induced barrier ablation provides protection
187 ing QTL variant highlights the importance of genetically influenced regulation in brain on the risks
188                                              Genetically inherited absence epilepsy in humans is typi
189 r, we studied a natural experiment involving genetically inherited traits, and find evidence that mal
190                   In a targeted screen, Cdk5 genetically interacted with Acinus (Acn), a primarily nu
191 245 significant genetic loci, among which 95 genetically interacted with other loci.
192                Notably, Kr-h1 physically and genetically interacts with dFOXO in vitro and in vivo to
193 ion, or MMP-2 and MMP-9 pharmacologically or genetically is sufficient to recapitulate transient syna
194         We further show that excitability of genetically isolated CRF-receptive (CRFR1) neurons in th
195 me-sequencing and exome-chip genotyping in a genetically isolated population from the Netherlands (n
196 abidopsis lyrata and Arabidopsis arenosa are genetically isolated, thus fitting this concept as "good
197 es with noncanonical amino acids (ncAAs) and genetically isolating synthetic organisms from natural o
198 filin is unable to induce apoptosis in cells genetically lacking p53.
199                    Here we find that in mice genetically lacking UCP1, cold-induced activation of met
200 ke 2 (CLEC2) gene families, which constitute genetically linked receptor-ligand pairs and are thought
201                          TREM2 mutations are genetically linked to Nasu-Hakola disease and associated
202 r, is a key regulator of inflammation and is genetically linked to two common and devastating neurode
203 rious experimental systems and appears to be genetically linked.
204         METHODS AND We aimed to test whether genetically lowered vitamin D levels were associated wit
205                         During recovery from genetically manipulated GSC depletion, E(z) knockdown ge
206 s the depression-like behaviors exhibited by genetically manipulated mice with D2(+) neuron-specific
207                                           To genetically map modifier loci in Atp6v1b1vtx/vtx mice, w
208                                 We show that genetically mediated increase in T2D risk also confers h
209                                              Genetically, MM can be divided into two groups according
210 rs in situ in combination with sophisticated genetically modified animal models, together with bioche
211                                 Therapy with genetically modified autologous T cells has shown great
212                             The use of live, genetically modified bacteria as delivery vehicles for b
213 ng note of caution on the employment of live genetically modified bacteria for the delivery of biolog
214 s of reduced Brd1 expression, we generated a genetically modified Brd1(+/-) mouse and subjected it to
215 ormal mice observing excessive scratching in genetically modified demonstrator mice.
216 type females, whereas wild-type males prefer genetically modified females.
217 us polarization regarding nanotechnology and genetically modified foods.
218              In mice, HO-1 overexpression by genetically modified HO-1 macrophage therapy was accompa
219 aturally occurring, cell culture-adapted, or genetically modified live attenuated ASFV.
220  are currently undergoing testing, including genetically modified live-attenuated parasite vaccines.
221 ese changes result in a mating preference of genetically modified males for wild-type females, wherea
222 ugs acting on the endocannabinoid system and genetically modified mice were used.
223                    During our examination of genetically modified mice, we discovered a series of pro
224                             We observed that genetically modified mosquitoes with increased immune ac
225 en-induced arthritis by using PGRN and IL-10 genetically modified mouse models.
226                                By generating genetically modified newborn mice that specifically lack
227  real sample environment of extracted DNA of Genetically Modified Organism products.
228 ld-type ACT1 promoter.Genetic isolation of a genetically modified organism represents a useful strate
229                  We illustrate our method on genetically modified organism, inhibition, dynamic range
230 osafety Research (ISBR) focused on so-called genetically modified organisms.
231                                              Genetically modified PAEC significantly prolonged clotti
232  suggesting that pre-transplant perfusion of genetically modified porcine organs with CHC may benefit
233                 Purpose Adoptive transfer of genetically modified T cells is being explored as a trea
234                 Adoptive transfer of T cells genetically modified to express a cancer-specific T-cell
235          Adoptive immunotherapy with T cells genetically modified to recognize tumors is a promising
236 tors (TCRs) or chimeric antigen receptors to genetically modify CD8(+) T cells or bulk T cells for tr
237 emarkably, the A1/D1 West population that is genetically more diverse than the entire A1/D1 East clus
238                               UC and CD were genetically more similar to each other (rG = 0.56) than
239  obtained with this traditional approach are genetically mosaic, yielding several types of cells with
240 ylated ELPs provide a versatile platform for genetically pre-programming self-assembly into micelles
241 re consistent with a causal effect of higher genetically predicted grip strength on lower fracture ri
242 Based on four SNPs, the odds ratio of AD per genetically predicted one standard deviation higher isol
243                                            A genetically predicted PR interval phenotype based on 645
244                                              Genetically predicted thyroid function was not associate
245 e strong evidence for an association between genetically predicted triglyceride levels and probabilit
246             In the ageing arm (70-84 years), genetically predicted triglyceride levels were not assoc
247 ere performed to examine the associations of genetically predicted triglycerides with two ageing phen
248 yndrome." We maintain that this condition is genetically predisposed and is associated with endotheli
249 rse to a rigid and deterministic sequence of genetically programmed events.
250 ean (Glycine max) seed coat has distinctive, genetically programmed patterns of pigmentation, and the
251                       Biofilm dispersal is a genetically programmed response enabling bacterial cells
252      Biofilm growth progresses through three genetically programmed stages: substratum attachment, in
253                                      In both genetically prone and experimentally induced mouse model
254                                By using mice genetically prone to CRC, we show that SGG colonization
255 sverse muscle sections from 25 patients with genetically-proven pathogenic CI variants.
256  near transcription start sites, whereas the genetically regulated CpGs are enriched in enhancers.
257 vels at more sites than genetic differences, genetically regulated sites tend to be less affected by
258 ases diagnosed >3 months into the study were genetically related (</=2 single-nucleotide polymorphism
259                            Conclusion In two genetically related cohorts at high risk for ASD, recipr
260                              This cluster of genetically related gonococcal isolates with decreased c
261                                    Groups of genetically related phages fall into either the high or
262 lls, leading to an anatomically separate but genetically related recurrence, and (3) multifocal disea
263 istinct subtypes rather than transmission of genetically related strains.
264 specialist strains but largely absent from a genetically related subset of pharyngitis isolates.
265  the subjects believed that the sisters were genetically related.
266 support the hypothesis that TP53 activates a genetically robust transcriptional program with highly d
267 coil domains, and that these activities were genetically separable from effects on MT stabilization.
268 hways, demonstrating that these pathways are genetically separable.
269                                      We also genetically separated the inflammatory and metabolic phe
270 ssically recognized role in the emergence of genetically "shifted" pandemic strains as well as its po
271 lon previously observed in S. cerevisiae was genetically shown in C. albicans using conditional TOR1
272 rmine patterns of chloroplast inheritance in genetically similar and divergent crosses, and then asso
273 of vaginal infection between these otherwise genetically similar species are possibly linked to patho
274 netic circuits in the engineered strain were genetically stable and functioned as intended over time.
275          Historically, VZV is among the most genetically stable herpesviruses, a notion supported by
276 that trail making is both phenotypically and genetically strongly associated with general cognitive f
277 nstrating that F5(L/L)Tfpi(+/-) lethality is genetically suppressible.
278                  Coeliac disease develops in genetically susceptible individuals who, in response to
279 ulation, induced by environmental factors in genetically susceptible individuals.
280 hood asthma, pneumonia, and bronchiolitis in genetically susceptible subjects.
281                                        Using genetically switchable models of senescence targeting H3
282 ained following coinfection with homologous, genetically tagged, pH1N1 viruses as a control.
283 linergic receptor alpha2 (Chrna2) in mice to genetically target the vesicular inhibitory amino acid t
284 brain slices from mice with channelrhodopsin genetically targeted to 5-HT neurons.
285                        In some model systems genetically-targeted expression of fluorescent proteins
286                                 Here we show genetically that dual SHMT1/2 knockout blocks HCT-116 co
287 lar, e.g. cryptic relationships, or that are genetically too different, e.g. population substructure.
288  is able to identify study subjects that are genetically too similar, e.g. cryptic relationships, or
289                                 Moreover, in genetically tractable Caenorhabditis elegans models, exp
290 rom the cold-inducible cspD2 promoter in the genetically tractable Haloarchaeon, Halobacterium sp.
291 arises from failure to distinguish between a genetically transmitted adaptation and a conditional res
292             The national registry of GenTAC (Genetically Triggered Thoracic Aortic Aneurysms and Card
293 nal Heart, Lung, and Blood Institute GenTAC (Genetically Triggered Thoracic Aortic Aneurysms and Card
294 striping is predominantly caused by the more genetically uniform A1/D1 East population.
295 nts co-located in the ICU were found to have genetically unrelated M. hominis isolates, excluding pat
296 ndividuals with histologically confirmed but genetically unsolved NM.
297 others, how tumors progressively become more genetically unstable due to increased chromosomal aneupl
298 proposed Dene-Yeniseian language family as a genetically valid grouping.
299                 This led to the expansion of genetically wild-type oligodendrocyte progenitor cells,
300 at extremely high intelligence is continuous genetically with normal-range intelligence in the popula

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