ライフサイエンスコーパス: genetically

1 trol before establishing acquired resistance genetically.

2 samples were closely related to one another genetically.

3 of patients with CIDs in Iran clinically and genetically.

4 t, Fogarty et al. (2017) used CRISPR/Cas9 to genetically ablate the OCT4 gene in human preimplantatio

5 Genetically ablating these neurons in juveniles disrupte

6 irst examples of serially transplantable and genetically accurate models of CMML.

7 leukemic cells in vivo, allowing creation of genetically accurate preclinical models of these disorde

8 Genetically admixed populations that speak creole langua

9 tion of O-GlcNAcylation pharmacologically or genetically aggravates the ischemia-induced brain damage

10 Using T cell-specific murine lines genetically altered in expression of p38alpha, and mice

11 Testing this hypothesis in genetically altered mice showed that the corresponding a

12 The interleukin-23 pathway is implicated genetically and biologically in the pathogenesis of Croh

13 e has a discrete pathophysiology and differs genetically and clinically from recessive Wolfram syndro

14 OTU, BU, and EB represent discrete lineages, genetically and developmentally specified sets of cells

15 n is structurally conserved with the Gn of a genetically and geographically distal hantavirus, Puumal

16 We probed these interactions genetically and identified second-site suppressors of le

17 om a common ancestor are expected to diverge genetically and phenotypically as they adapt to differen

18 MM is genetically and phenotypically heterogeneous, so targeti

19 This approach provides genetically and spatially targetable, repeatable and tem

20 islet or celiac disease (CD) autoimmunity in genetically at-risk children prospectively followed up f

21 , one of the most promising candidates for a genetically attenuated vaccine against malaria (5) , as

22 (mES) cell lines targeting 16,970 genes with genetically barcoded, conditional and reversible mutatio

23 pal causal interactions between the primary, genetically based organic processes of evolution and the

24 editary NS and 5 (5%) patients with probably genetically caused NS.

25 = 3 x 10(-3)), suggesting a path forward for genetically characterizing more complex cases of autism.

26 ted macular degeneration (AMD), a common and genetically complex disorder, which can lead to misdiagn

27 te that GWAS of single heritable features of genetically complex disorders followed by chromosome con

28 38% of the risk, suggesting that MPB is less genetically complex than other complex traits.

29 tion for which 30% of patients are without a genetically confirmed diagnosis.

30 The prevalence of genetically confirmed FH was 8.7% (95% confidence interv

31 o diagnose 4 (44%) and 3 (33%) patients with genetically confirmed FH, respectively.

32 an in his 70s with a longstanding history of genetically confirmed HCM presented with rapid developme

33 re assessed in patients aged 3-25 years with genetically confirmed type 2 or non-ambulatory type 3 SM

34 In contrast, genetically corrected ESCs differentiated to CD4 + or CD

35 As a consequence, genetically corrected HSC-derived macrophages were able

36 Transplantation of genetically corrected HSCs into Ifngammar1(-/-) mice bef

37 rating that distinct cognitive abilities are genetically correlated and thus share a biological subst

38 te at the first position) were significantly genetically correlated with all the T2D-related traits.

39 We genetically cross two lethal parasites with distinct dis

40 n is a major driver of the transformation of genetically defective liver stem cells (LSCs) into highl

41 izure disorder, kidney disease duration, and genetically defined ancestry.

42 Together with new observations from genetically defined autism risk alleles and rodent model

43 initially developed for profiling mRNA from genetically defined cell types in complex tissues.

44 In genetically defined mouse models, studies of postnatal s

45 in neuroscience that enable the analysis of genetically defined neuronal circuits with unprecedented

46 senting a tethered ligand at the synapses of genetically defined neurons, thereby activating the path

47 then validated on a commercially available, genetically defined PD-L1 engineered cell line array wit

48 examined how the anatomical composition of a genetically defined population of balance interneurons i

49 , and discovered a new behavioral role for a genetically defined population of central vestibular neu

50 dentification of proteins from spatially and genetically defined regions of the brain.

51 eviously untreated, clinically-annotated and genetically-defined high grade gliomas.

52 Here, we genetically deleted Srebf-2 from hepatocytes and confirm

53 ssion of FLOWERING LOCUS T This phenotype is genetically dependent on CO.

54 supplements or fuels; thus, a feedstock with genetically designed and tunable degree of unsaturation

55 junction cardiomyopathy, typically caused by genetically determined abnormalities of cardiac desmosom

56 Genetically determined accessibility was enriched at dis

57 ning reflects the influence of experience on genetically determined circuitry, but little is known ab

58 These results suggest that genetically determined Cp levels can alter susceptibilit

59 affect the epigenome and potentially rescue genetically determined disease phenotypes.

60 An increase of 10 cm in genetically determined height was associated with increa

61 ts were initially referred with suspicion of genetically determined hypertrophic cardiomyopathy.

62 e interaction between parasite virulence and genetically determined levels of host-plant resistance a

63 hese findings strengthen the hypothesis that genetically determined local dysregulation of dietary vi

64 To examine whether HCV has a genetically determined lymphotropism through a co-recept

65 Mitochondrial disorders are genetically determined metabolic diseases due to a bioch

66 GSS is a genetically determined TSE caused by a range of mutation

67 Although its properties are in part genetically determined, altered light-dark environment c

68 Oxetane grafting of the genetically detoxified diphtheria toxin CRM197 improves

69 nerates a spectrum of genome diversity(8) or genetically discrete populations(9,10).

70 lic modeling approach was developed using 19 genetically distant maize (Zea mays) lines from Europe a

71 Mixed lineage leukemia (MLL) represents a genetically distinct and aggressive subset of human acut

72 th timing of reproduction are shared between genetically distinct and geographically distant populati

73 WGS identified 1 or more isolates that were genetically distinct despite having the outbreak pulsed-

74 idespread cis variation in RNA editing among genetically distinct individuals and sheds light on poss

75 nvironmental toxicants differentially affect genetically distinct individuals, but the mechanisms con

76 recurrence, and (3) multifocal disease with genetically distinct lesions.

77 Mediterranean fin whales comprise a genetically distinct population, listed as Vulnerable (V

78 esocosms originating from geographically and genetically distinct populations in Switzerland.

79 Here, we identify several genetically distinct populations of CeA neurons that med

80 that patients with MCC may develop a second genetically distinct primary tumor; in this case, the su

81 Cases 1 and 4 were verified as genetically distinct primary tumors and did not harbor s

82 The development of multifocal, genetically distinct tumours is suggestive of a field de

83 arentally, often without recombination among genetically divergent organelles.

84 cell wall polysaccharides collected from 331 genetically diverse Brassica napus cultivars and used th

85 Genetically diverse groups produced root litter that had

86 observed in soil conditioned by siblings and genetically diverse groups.

87 cer profiling of a cohort of more than forty genetically diverse human colorectal cancer (CRC) specim

88 er predict and optimize humoral responses in genetically diverse human populations, with immediate im

89 Preexisting cross-reactive T cells to genetically diverse IAV strains were found in the majori

90 sting, cross-reactive T cells in children to genetically diverse influenza A virus (IAV) strains to w

91 Bacteria represent the most genetically diverse kingdom of life.

92 Significantly, less genetically diverse mangrove species suffered much great

93 Here, we leveraged a unique, genetically diverse population of C. neoformans from sub

94 Within their hosts, they exist as genetically diverse populations (i.e., viral mutant swar

95 t adaptation if the founders originated from genetically diverse populations.

96 distinct disease phenotypes, and identify 43 genetically diverse progeny by typing with microsatellit

97 is conserved not only during infection with genetically diverse Toxoplasma strains but also with Neo

98 annoside, reduces intestinal colonization of genetically diverse UPEC isolates, while simultaneously

99 The muscular dystrophies are genetically diverse.

100 Susceptibility to infection is in part genetically driven, and C57BL/6 mice resist various path

101 Genetically elevated circulating levels of C-reactive pr

102 The ability to genetically encode an expanded set of building blocks wi

103 Here we describe DeActs, genetically encoded actin-modifying polypeptides, which

104 Bacterial cell shape is a genetically encoded and inherited feature that is optimi

105 with sensitivity surpassing those of purely genetically encoded approaches.

106 n-canonical amino acid coumarin-tyrosine was genetically encoded at Y671, a residue proximal to the s

107 siological studies, we developed a sensitive genetically encoded bilirubin (BR)-inducible fluorescenc

108 Using genetically encoded Ca(2+) sensors, we found that mitoch

109 We used a genetically encoded calcium indicator and readily detect

110 ng in vivo two-color two-photon imaging with genetically encoded calcium indicators, we demonstrate t

111 , we developed an alternative approach using genetically encoded chemical tags CLIP, SNAP, Halo, and

112 or sensing EGFR activity in cells, we used a genetically encoded CrkII-based biosensor which undergoe

113 To address this gap, a genetically encoded cyclic peptide was designed based on

114 Utilizing a novel ratiometric genetically encoded cytosolic Ca(2+) indicator, Salsa6f,

115 We developed novel genetically encoded ER-targeted low-affinity Ca(2+) indi

116 esponses of individual osteocytes by using a genetically encoded fluorescent Ca(2+) indicator.

117 We describe the development of a genetically encoded fluorescent tRNA fusion with the pot

118 e high spatiotemporal resolution afforded by genetically encoded Forster resonance energy transfer (F

119 We used a genetically encoded high throughput screening platform t

120 increases thermotolerance in addition to the genetically encoded HSR.

121 lta,-dehydrolysine, an allysine precursor is genetically encoded in E. coli.

122 The use of genetically encoded noncanonical amino acids (ncAAs) to

123 The genetically encoded photo-cross-linkers promise to offer

124 ery, evolution and generalization of a fully genetically encoded platform for producing chiral organo

125 To this end, we used genetically encoded probes consisting of the PtdIns4P-bi

126 Genetically encoded sensors based on fluorescence resona

127 for the "assembly line" biosynthesis of many genetically encoded small molecules.

128 alamin binding domain (CarHC) proteins using genetically encoded SpyTag-SpyCatcher chemistry under mi

129 We have previously genetically encoded the noncanonical amino acid 5-hydrox

130 Genetically encoded voltage indicators create an opportu

131 In particular, while genetically encoded voltage indicators have shown promis

132 e capability to resolve the responses of two genetically encoded Zn(2+) sensors at a range of time po

133 Using genetically-encoded, site-specific incorporation of unna

134 By genetically encoding this sensor in the human malarial p

135 AM composition during gliomagenesis, we used genetically engineered and GL261-induced mouse models in

136 o create biosynthetic excitable tissues from genetically engineered and immortalized HEK293 cells wit

137 ly attach disease-associated autoantigens to genetically engineered and to unmodified red blood cells

138 Here, we used cells from human tumors and a genetically engineered autochthonous mouse model of soft

139 elastomer hybrids that host various types of genetically engineered bacterial cells.

140 en globally used in basic plant research and genetically engineered crops (1-4) .

141 rence in pHCA production yield between three genetically engineered E. coli strains was successfully

142 Serratia AS1 was genetically engineered for secretion of anti-Plasmodium

143 Genetically engineered mice, with human P2X7R, revealed

144 d-test" cycle paradigm, massive libraries of genetically engineered microbes can be constructed and t

145 value-added chemicals.Screening libraries of genetically engineered microbes for secreted products is

146 ine resistance by utilizing tissues from the genetically engineered mouse model and human pancreatic

147 Sensory denervation of a genetically engineered mouse model of PDAC led to loss o

148 To visualize TRPV1-lineage axons, a genetically engineered mouse model was used in which a f

149 Preclinical studies using genetically engineered mouse models (GEMM) have the pote

150 can be achieved using organoids derived from genetically engineered mouse models (GEMMs), wild-type o

151 n KRAS mutant tumors has been established in genetically engineered mouse models and human tumor cell

152 In both genetically engineered mouse models and murine xenograft

153 We used genetically engineered mouse models of glioma and quanti

154 Loss of EphA2 function in both human and genetically engineered mouse models of TNBC reduced tumo

155 Genetically engineered mouse models that employ site-spe

156 In xenograft and genetically engineered mouse models, the WDR4/PML axis e

157 against skin carcinogenesis was examined in genetically engineered mouse models.

158 s, fluctuations are typically assessed using genetically engineered reporter cell lines that produce

159 Genetically engineered T cells are powerful new medicine

160 iet (HFD) induced diabetic mouse model and a genetically engineered T2DM rat model.

161 infusion of bone marrow-derived macrophages genetically engineered to overexpress murine MCAD marked

162 ute a single factor, both phenotypically and genetically, even after controlling for g This spatial a

163 truncated version of flagellin (NtCFlg) was genetically fused to the N- or C-terminus of Bet v 1.

164 ic male-male courtship and indicate that the genetically hard-wired neural mechanisms enforcing behav

165 HGF is a genetically heterogeneous disorder and can be transmitte

166 llectual disability (ID) is a clinically and genetically heterogeneous disorder, affecting 1-3% of th

167 mocytomas and paragangliomas are infrequent, genetically heterogeneous neuroendocrine tumors.

168 rome (HLHS), a severe CHD, is multigenic and genetically heterogeneous.

169 that FTD is clinically, pathologically, and genetically heterogeneous.

170 SHFYNG syndromes, and confirms that OTCS is genetically heterogeneous.

171 Congenital myopathies are phenotypically and genetically heterogeneous.

172 To clarify, we assessed whether people with genetically higher calcium had a higher risk of coronary

173 growing bacterium typically divides into two genetically identical and morphologically similar sister

174 has gained popularity as a method to produce genetically identical animals or superior animals for re

175 Genetically identical cells frequently display substanti

176 The quiescence-exit process is noisy even in genetically identical cells under the same environmental

177 Quiescence exit is highly noisy even for genetically identical cells under the same environmental

178 rsistent gastrointestinal carriage states in genetically identical mice.

179 lations of bacilli can survive despite being genetically identical to those that are easily killed.

180 symptoms in a sample of N = 100 monozygotic (genetically identical), adolescent twins.

181 that differ in life-history strategy but are genetically identical.

182 manipulations and trans-synaptic tracing of genetically identified dorsal horn and RVM neurons to un

183 Using CRISPR/Cas9 to genetically inactivate a TWIST2 orthologue, we suppresse

184 sed at these inhibitory synapses and must be genetically inactivated together with Syt2 to achieve a

185 hese different lifestyles occur in separate, genetically incompatible species.

186 Moreover, genetically induced barrier ablation provides protection

187 ing QTL variant highlights the importance of genetically influenced regulation in brain on the risks

188 Genetically inherited absence epilepsy in humans is typi

189 r, we studied a natural experiment involving genetically inherited traits, and find evidence that mal

190 In a targeted screen, Cdk5 genetically interacted with Acinus (Acn), a primarily nu

191 245 significant genetic loci, among which 95 genetically interacted with other loci.

192 Notably, Kr-h1 physically and genetically interacts with dFOXO in vitro and in vivo to

193 ion, or MMP-2 and MMP-9 pharmacologically or genetically is sufficient to recapitulate transient syna

194 We further show that excitability of genetically isolated CRF-receptive (CRFR1) neurons in th

195 me-sequencing and exome-chip genotyping in a genetically isolated population from the Netherlands (n

196 abidopsis lyrata and Arabidopsis arenosa are genetically isolated, thus fitting this concept as "good

197 es with noncanonical amino acids (ncAAs) and genetically isolating synthetic organisms from natural o

198 filin is unable to induce apoptosis in cells genetically lacking p53.

199 Here we find that in mice genetically lacking UCP1, cold-induced activation of met

200 ke 2 (CLEC2) gene families, which constitute genetically linked receptor-ligand pairs and are thought

201 TREM2 mutations are genetically linked to Nasu-Hakola disease and associated

202 r, is a key regulator of inflammation and is genetically linked to two common and devastating neurode

203 rious experimental systems and appears to be genetically linked.

204 METHODS AND We aimed to test whether genetically lowered vitamin D levels were associated wit

205 During recovery from genetically manipulated GSC depletion, E(z) knockdown ge

206 s the depression-like behaviors exhibited by genetically manipulated mice with D2(+) neuron-specific

207 To genetically map modifier loci in Atp6v1b1vtx/vtx mice, w

208 We show that genetically mediated increase in T2D risk also confers h

209 Genetically, MM can be divided into two groups according

210 rs in situ in combination with sophisticated genetically modified animal models, together with bioche

211 Therapy with genetically modified autologous T cells has shown great

212 The use of live, genetically modified bacteria as delivery vehicles for b

213 ng note of caution on the employment of live genetically modified bacteria for the delivery of biolog

214 s of reduced Brd1 expression, we generated a genetically modified Brd1(+/-) mouse and subjected it to

215 ormal mice observing excessive scratching in genetically modified demonstrator mice.

216 type females, whereas wild-type males prefer genetically modified females.

217 us polarization regarding nanotechnology and genetically modified foods.

218 In mice, HO-1 overexpression by genetically modified HO-1 macrophage therapy was accompa

219 aturally occurring, cell culture-adapted, or genetically modified live attenuated ASFV.

220 are currently undergoing testing, including genetically modified live-attenuated parasite vaccines.

221 ese changes result in a mating preference of genetically modified males for wild-type females, wherea

222 ugs acting on the endocannabinoid system and genetically modified mice were used.

223 During our examination of genetically modified mice, we discovered a series of pro

224 We observed that genetically modified mosquitoes with increased immune ac

225 en-induced arthritis by using PGRN and IL-10 genetically modified mouse models.

226 By generating genetically modified newborn mice that specifically lack

227 real sample environment of extracted DNA of Genetically Modified Organism products.

228 ld-type ACT1 promoter.Genetic isolation of a genetically modified organism represents a useful strate

229 We illustrate our method on genetically modified organism, inhibition, dynamic range

230 osafety Research (ISBR) focused on so-called genetically modified organisms.

231 Genetically modified PAEC significantly prolonged clotti

232 suggesting that pre-transplant perfusion of genetically modified porcine organs with CHC may benefit

233 Purpose Adoptive transfer of genetically modified T cells is being explored as a trea

234 Adoptive transfer of T cells genetically modified to express a cancer-specific T-cell

235 Adoptive immunotherapy with T cells genetically modified to recognize tumors is a promising

236 tors (TCRs) or chimeric antigen receptors to genetically modify CD8(+) T cells or bulk T cells for tr

237 emarkably, the A1/D1 West population that is genetically more diverse than the entire A1/D1 East clus

238 UC and CD were genetically more similar to each other (rG = 0.56) than

239 obtained with this traditional approach are genetically mosaic, yielding several types of cells with

240 ylated ELPs provide a versatile platform for genetically pre-programming self-assembly into micelles

241 re consistent with a causal effect of higher genetically predicted grip strength on lower fracture ri

242 Based on four SNPs, the odds ratio of AD per genetically predicted one standard deviation higher isol

243 A genetically predicted PR interval phenotype based on 645

244 Genetically predicted thyroid function was not associate

245 e strong evidence for an association between genetically predicted triglyceride levels and probabilit

246 In the ageing arm (70-84 years), genetically predicted triglyceride levels were not assoc

247 ere performed to examine the associations of genetically predicted triglycerides with two ageing phen

248 yndrome." We maintain that this condition is genetically predisposed and is associated with endotheli

249 rse to a rigid and deterministic sequence of genetically programmed events.

250 ean (Glycine max) seed coat has distinctive, genetically programmed patterns of pigmentation, and the

251 Biofilm dispersal is a genetically programmed response enabling bacterial cells

252 Biofilm growth progresses through three genetically programmed stages: substratum attachment, in

253 In both genetically prone and experimentally induced mouse model

254 By using mice genetically prone to CRC, we show that SGG colonization

255 sverse muscle sections from 25 patients with genetically-proven pathogenic CI variants.

256 near transcription start sites, whereas the genetically regulated CpGs are enriched in enhancers.

257 vels at more sites than genetic differences, genetically regulated sites tend to be less affected by

258 ases diagnosed >3 months into the study were genetically related (</=2 single-nucleotide polymorphism

259 Conclusion In two genetically related cohorts at high risk for ASD, recipr

260 This cluster of genetically related gonococcal isolates with decreased c

261 Groups of genetically related phages fall into either the high or

262 lls, leading to an anatomically separate but genetically related recurrence, and (3) multifocal disea

263 istinct subtypes rather than transmission of genetically related strains.

264 specialist strains but largely absent from a genetically related subset of pharyngitis isolates.

265 the subjects believed that the sisters were genetically related.

266 support the hypothesis that TP53 activates a genetically robust transcriptional program with highly d

267 coil domains, and that these activities were genetically separable from effects on MT stabilization.

268 hways, demonstrating that these pathways are genetically separable.

269 We also genetically separated the inflammatory and metabolic phe

270 ssically recognized role in the emergence of genetically "shifted" pandemic strains as well as its po

271 lon previously observed in S. cerevisiae was genetically shown in C. albicans using conditional TOR1

272 rmine patterns of chloroplast inheritance in genetically similar and divergent crosses, and then asso

273 of vaginal infection between these otherwise genetically similar species are possibly linked to patho

274 netic circuits in the engineered strain were genetically stable and functioned as intended over time.

275 Historically, VZV is among the most genetically stable herpesviruses, a notion supported by

276 that trail making is both phenotypically and genetically strongly associated with general cognitive f

277 nstrating that F5(L/L)Tfpi(+/-) lethality is genetically suppressible.

278 Coeliac disease develops in genetically susceptible individuals who, in response to

279 ulation, induced by environmental factors in genetically susceptible individuals.

280 hood asthma, pneumonia, and bronchiolitis in genetically susceptible subjects.

281 Using genetically switchable models of senescence targeting H3

282 ained following coinfection with homologous, genetically tagged, pH1N1 viruses as a control.

283 linergic receptor alpha2 (Chrna2) in mice to genetically target the vesicular inhibitory amino acid t

284 brain slices from mice with channelrhodopsin genetically targeted to 5-HT neurons.

285 In some model systems genetically-targeted expression of fluorescent proteins

286 Here we show genetically that dual SHMT1/2 knockout blocks HCT-116 co

287 lar, e.g. cryptic relationships, or that are genetically too different, e.g. population substructure.

288 is able to identify study subjects that are genetically too similar, e.g. cryptic relationships, or

289 Moreover, in genetically tractable Caenorhabditis elegans models, exp

290 rom the cold-inducible cspD2 promoter in the genetically tractable Haloarchaeon, Halobacterium sp.

291 arises from failure to distinguish between a genetically transmitted adaptation and a conditional res

292 The national registry of GenTAC (Genetically Triggered Thoracic Aortic Aneurysms and Card

293 nal Heart, Lung, and Blood Institute GenTAC (Genetically Triggered Thoracic Aortic Aneurysms and Card

294 striping is predominantly caused by the more genetically uniform A1/D1 East population.

295 nts co-located in the ICU were found to have genetically unrelated M. hominis isolates, excluding pat

296 ndividuals with histologically confirmed but genetically unsolved NM.

297 others, how tumors progressively become more genetically unstable due to increased chromosomal aneupl

298 proposed Dene-Yeniseian language family as a genetically valid grouping.

299 This led to the expansion of genetically wild-type oligodendrocyte progenitor cells,

300 at extremely high intelligence is continuous genetically with normal-range intelligence in the popula