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1 trol before establishing acquired resistance genetically.
2 samples were closely related to one another genetically.
3 of patients with CIDs in Iran clinically and genetically.
4 t, Fogarty et al. (2017) used CRISPR/Cas9 to genetically ablate the OCT4 gene in human preimplantatio
7 leukemic cells in vivo, allowing creation of genetically accurate preclinical models of these disorde
9 tion of O-GlcNAcylation pharmacologically or genetically aggravates the ischemia-induced brain damage
12 The interleukin-23 pathway is implicated genetically and biologically in the pathogenesis of Croh
13 e has a discrete pathophysiology and differs genetically and clinically from recessive Wolfram syndro
14 OTU, BU, and EB represent discrete lineages, genetically and developmentally specified sets of cells
15 n is structurally conserved with the Gn of a genetically and geographically distal hantavirus, Puumal
17 om a common ancestor are expected to diverge genetically and phenotypically as they adapt to differen
20 islet or celiac disease (CD) autoimmunity in genetically at-risk children prospectively followed up f
21 , one of the most promising candidates for a genetically attenuated vaccine against malaria (5) , as
22 (mES) cell lines targeting 16,970 genes with genetically barcoded, conditional and reversible mutatio
23 pal causal interactions between the primary, genetically based organic processes of evolution and the
25 = 3 x 10(-3)), suggesting a path forward for genetically characterizing more complex cases of autism.
26 ted macular degeneration (AMD), a common and genetically complex disorder, which can lead to misdiagn
27 te that GWAS of single heritable features of genetically complex disorders followed by chromosome con
32 an in his 70s with a longstanding history of genetically confirmed HCM presented with rapid developme
33 re assessed in patients aged 3-25 years with genetically confirmed type 2 or non-ambulatory type 3 SM
37 rating that distinct cognitive abilities are genetically correlated and thus share a biological subst
38 te at the first position) were significantly genetically correlated with all the T2D-related traits.
40 n is a major driver of the transformation of genetically defective liver stem cells (LSCs) into highl
45 in neuroscience that enable the analysis of genetically defined neuronal circuits with unprecedented
46 senting a tethered ligand at the synapses of genetically defined neurons, thereby activating the path
47 then validated on a commercially available, genetically defined PD-L1 engineered cell line array wit
48 examined how the anatomical composition of a genetically defined population of balance interneurons i
49 , and discovered a new behavioral role for a genetically defined population of central vestibular neu
54 supplements or fuels; thus, a feedstock with genetically designed and tunable degree of unsaturation
55 junction cardiomyopathy, typically caused by genetically determined abnormalities of cardiac desmosom
57 ning reflects the influence of experience on genetically determined circuitry, but little is known ab
62 e interaction between parasite virulence and genetically determined levels of host-plant resistance a
63 hese findings strengthen the hypothesis that genetically determined local dysregulation of dietary vi
70 lic modeling approach was developed using 19 genetically distant maize (Zea mays) lines from Europe a
71 Mixed lineage leukemia (MLL) represents a genetically distinct and aggressive subset of human acut
72 th timing of reproduction are shared between genetically distinct and geographically distant populati
73 WGS identified 1 or more isolates that were genetically distinct despite having the outbreak pulsed-
74 idespread cis variation in RNA editing among genetically distinct individuals and sheds light on poss
75 nvironmental toxicants differentially affect genetically distinct individuals, but the mechanisms con
80 that patients with MCC may develop a second genetically distinct primary tumor; in this case, the su
84 cell wall polysaccharides collected from 331 genetically diverse Brassica napus cultivars and used th
87 cer profiling of a cohort of more than forty genetically diverse human colorectal cancer (CRC) specim
88 er predict and optimize humoral responses in genetically diverse human populations, with immediate im
90 sting, cross-reactive T cells in children to genetically diverse influenza A virus (IAV) strains to w
96 distinct disease phenotypes, and identify 43 genetically diverse progeny by typing with microsatellit
97 is conserved not only during infection with genetically diverse Toxoplasma strains but also with Neo
98 annoside, reduces intestinal colonization of genetically diverse UPEC isolates, while simultaneously
106 n-canonical amino acid coumarin-tyrosine was genetically encoded at Y671, a residue proximal to the s
107 siological studies, we developed a sensitive genetically encoded bilirubin (BR)-inducible fluorescenc
110 ng in vivo two-color two-photon imaging with genetically encoded calcium indicators, we demonstrate t
111 , we developed an alternative approach using genetically encoded chemical tags CLIP, SNAP, Halo, and
112 or sensing EGFR activity in cells, we used a genetically encoded CrkII-based biosensor which undergoe
118 e high spatiotemporal resolution afforded by genetically encoded Forster resonance energy transfer (F
124 ery, evolution and generalization of a fully genetically encoded platform for producing chiral organo
128 alamin binding domain (CarHC) proteins using genetically encoded SpyTag-SpyCatcher chemistry under mi
132 e capability to resolve the responses of two genetically encoded Zn(2+) sensors at a range of time po
135 AM composition during gliomagenesis, we used genetically engineered and GL261-induced mouse models in
136 o create biosynthetic excitable tissues from genetically engineered and immortalized HEK293 cells wit
137 ly attach disease-associated autoantigens to genetically engineered and to unmodified red blood cells
138 Here, we used cells from human tumors and a genetically engineered autochthonous mouse model of soft
141 rence in pHCA production yield between three genetically engineered E. coli strains was successfully
144 d-test" cycle paradigm, massive libraries of genetically engineered microbes can be constructed and t
145 value-added chemicals.Screening libraries of genetically engineered microbes for secreted products is
146 ine resistance by utilizing tissues from the genetically engineered mouse model and human pancreatic
150 can be achieved using organoids derived from genetically engineered mouse models (GEMMs), wild-type o
151 n KRAS mutant tumors has been established in genetically engineered mouse models and human tumor cell
154 Loss of EphA2 function in both human and genetically engineered mouse models of TNBC reduced tumo
158 s, fluctuations are typically assessed using genetically engineered reporter cell lines that produce
161 infusion of bone marrow-derived macrophages genetically engineered to overexpress murine MCAD marked
162 ute a single factor, both phenotypically and genetically, even after controlling for g This spatial a
163 truncated version of flagellin (NtCFlg) was genetically fused to the N- or C-terminus of Bet v 1.
164 ic male-male courtship and indicate that the genetically hard-wired neural mechanisms enforcing behav
166 llectual disability (ID) is a clinically and genetically heterogeneous disorder, affecting 1-3% of th
172 To clarify, we assessed whether people with genetically higher calcium had a higher risk of coronary
173 growing bacterium typically divides into two genetically identical and morphologically similar sister
174 has gained popularity as a method to produce genetically identical animals or superior animals for re
176 The quiescence-exit process is noisy even in genetically identical cells under the same environmental
177 Quiescence exit is highly noisy even for genetically identical cells under the same environmental
179 lations of bacilli can survive despite being genetically identical to those that are easily killed.
182 manipulations and trans-synaptic tracing of genetically identified dorsal horn and RVM neurons to un
184 sed at these inhibitory synapses and must be genetically inactivated together with Syt2 to achieve a
187 ing QTL variant highlights the importance of genetically influenced regulation in brain on the risks
189 r, we studied a natural experiment involving genetically inherited traits, and find evidence that mal
193 ion, or MMP-2 and MMP-9 pharmacologically or genetically is sufficient to recapitulate transient syna
195 me-sequencing and exome-chip genotyping in a genetically isolated population from the Netherlands (n
196 abidopsis lyrata and Arabidopsis arenosa are genetically isolated, thus fitting this concept as "good
197 es with noncanonical amino acids (ncAAs) and genetically isolating synthetic organisms from natural o
200 ke 2 (CLEC2) gene families, which constitute genetically linked receptor-ligand pairs and are thought
202 r, is a key regulator of inflammation and is genetically linked to two common and devastating neurode
206 s the depression-like behaviors exhibited by genetically manipulated mice with D2(+) neuron-specific
210 rs in situ in combination with sophisticated genetically modified animal models, together with bioche
213 ng note of caution on the employment of live genetically modified bacteria for the delivery of biolog
214 s of reduced Brd1 expression, we generated a genetically modified Brd1(+/-) mouse and subjected it to
220 are currently undergoing testing, including genetically modified live-attenuated parasite vaccines.
221 ese changes result in a mating preference of genetically modified males for wild-type females, wherea
228 ld-type ACT1 promoter.Genetic isolation of a genetically modified organism represents a useful strate
232 suggesting that pre-transplant perfusion of genetically modified porcine organs with CHC may benefit
236 tors (TCRs) or chimeric antigen receptors to genetically modify CD8(+) T cells or bulk T cells for tr
237 emarkably, the A1/D1 West population that is genetically more diverse than the entire A1/D1 East clus
239 obtained with this traditional approach are genetically mosaic, yielding several types of cells with
240 ylated ELPs provide a versatile platform for genetically pre-programming self-assembly into micelles
241 re consistent with a causal effect of higher genetically predicted grip strength on lower fracture ri
242 Based on four SNPs, the odds ratio of AD per genetically predicted one standard deviation higher isol
245 e strong evidence for an association between genetically predicted triglyceride levels and probabilit
247 ere performed to examine the associations of genetically predicted triglycerides with two ageing phen
248 yndrome." We maintain that this condition is genetically predisposed and is associated with endotheli
250 ean (Glycine max) seed coat has distinctive, genetically programmed patterns of pigmentation, and the
252 Biofilm growth progresses through three genetically programmed stages: substratum attachment, in
256 near transcription start sites, whereas the genetically regulated CpGs are enriched in enhancers.
257 vels at more sites than genetic differences, genetically regulated sites tend to be less affected by
258 ases diagnosed >3 months into the study were genetically related (</=2 single-nucleotide polymorphism
262 lls, leading to an anatomically separate but genetically related recurrence, and (3) multifocal disea
264 specialist strains but largely absent from a genetically related subset of pharyngitis isolates.
266 support the hypothesis that TP53 activates a genetically robust transcriptional program with highly d
267 coil domains, and that these activities were genetically separable from effects on MT stabilization.
270 ssically recognized role in the emergence of genetically "shifted" pandemic strains as well as its po
271 lon previously observed in S. cerevisiae was genetically shown in C. albicans using conditional TOR1
272 rmine patterns of chloroplast inheritance in genetically similar and divergent crosses, and then asso
273 of vaginal infection between these otherwise genetically similar species are possibly linked to patho
274 netic circuits in the engineered strain were genetically stable and functioned as intended over time.
276 that trail making is both phenotypically and genetically strongly associated with general cognitive f
283 linergic receptor alpha2 (Chrna2) in mice to genetically target the vesicular inhibitory amino acid t
287 lar, e.g. cryptic relationships, or that are genetically too different, e.g. population substructure.
288 is able to identify study subjects that are genetically too similar, e.g. cryptic relationships, or
290 rom the cold-inducible cspD2 promoter in the genetically tractable Haloarchaeon, Halobacterium sp.
291 arises from failure to distinguish between a genetically transmitted adaptation and a conditional res
293 nal Heart, Lung, and Blood Institute GenTAC (Genetically Triggered Thoracic Aortic Aneurysms and Card
295 nts co-located in the ICU were found to have genetically unrelated M. hominis isolates, excluding pat
297 others, how tumors progressively become more genetically unstable due to increased chromosomal aneupl
300 at extremely high intelligence is continuous genetically with normal-range intelligence in the popula
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