ライフサイエンスコーパス: genetically altered

1 lies in which insulin signaling activity was genetically altered.

2 ated when the M cell oscillator is absent or genetically altered.

3 recombinant human Orc2 subunit that had been genetically altered.

4 ectin on adipose tissue in mouse models with genetically altered adiponectin levels.

5 Using combinations of genetically altered and immunodepleted mice, we found ev

6 ES cell lines that can be expanded in vitro, genetically altered, and differentiated into cell types

7 lines, in which MSR gene expression has been genetically altered, and observed a positive correlation

8 By using a variety of different genetically altered animal models and biophysical experi

9 cid transporters, and emerging evidence from genetically altered animal models for some of these prot

10 ere are endless possibilities for generating genetically altered animal models with which to gain ins

11 easingly powerful flow cytometry analysis of genetically altered animals (knockouts and transgenics)

12 aptive immune systems, are being explored in genetically altered animals and in exposure models of th

13 ulting from altered gene expression (e.g. in genetically altered animals or in human genetic disorder

14 ion mechanisms offers the opportunity to use genetically altered animals to specifically target these

15 longitudinal studies in animals and to study genetically altered animals.

16 riments in which CSQN expression levels were genetically altered as well as to reproduce nanoscopic m

17 air pathways for PARP-DNA complexes using 30 genetically altered avian DT40 cell lines with preestabl

18 d, perhaps, endogenous antigens generated by genetically altered bone marrow cells.

19 LK) is a receptor tyrosine kinase that, when genetically altered by mutation, amplification, chromoso

20 tain cellular behaviors that mirror those of genetically altered cell lines.

21 Genetically altered cell sizes had little effect on tiss

22 s, differentiating cell culture systems, and genetically altered cells and animals.

23 Single cell measurements of the genetically altered cells are shown to be consistent wit

24 Genetically altered cells in the superficial portions of

25 When these genetically altered cells were placed within the in vivo

26 ay influence diseases that derive from a few genetically altered cells, such as cancer.

27 onsidered epigenetic processes that act upon genetically altered cells.

28 for 12 months after the implantation of the genetically altered cells.

29 fe mechanisms to terminate therapy or remove genetically altered cells.

30 requires an efficient mechanism to eliminate genetically altered cells.

31 osis (ALS), may derive from a small focus of genetically altered cells.

32 have bearing upon Na(+) channel function in genetically altered channels and under pathophysiologic

33 opportunity to examine the ultrastructure of genetically altered cisternal synapses.

34 n defective enamel, and the diverse group of genetically altered conditions is collectively known as

35 Our data indicate that genetically altered core pathways and regulatory process

36 We find that mice bearing genetically altered cytoplasmic region of ephrinB2 have

37 Surprisingly, aged mice but not mice with genetically altered DC function had greater production o

38 d starvation at 30 degrees C in strains with genetically altered DnaK content.

39 ction of dopamine in feeding and locomotion, genetically altered, dopamine-deficient mice were treate

40 anism of survivin gene regulation that, when genetically altered during the process of tumorigenesis,

41 ated cell populations derived from normal or genetically altered embryonic stem cells in vitro.

42 Polymerase activity of the genetically altered enzyme on primed M13 DNA is only 12%

43 erties and heat inactivation profiles of the genetically altered enzyme over-produced at 30 degrees C

44 To examine the role of this region, a genetically altered enzyme that lacked residues 144-157

45 We generated or obtained flies with genetically altered expression of each of three Drosophi

46 and proximity ligation assays in cells with genetically altered expression of the studied molecules.

47 Implantation of genetically altered fibroblasts that produce factor VIII

48 ytes, embryonic stem cells, tetratoma cells, genetically altered fibroblasts, smooth muscle cells, an

49 The genetically altered gene 4 proteins were examined for th

50 B virus (HBV) positive, seeking to identify genetically altered genes and pathways implicated in HBV

51 leotide to DNA polymerase, we have used four genetically altered gp4 to demonstrate that both the RNA

52 However, a recently developed mouse model of genetically altered hearing (Tectb(-/-)) shows decreased

53 atitis model, particularly those requiring a genetically altered host or specific immunologic reagent

54 aluation of immune responses associated with genetically altered HSCs, including primary immunodefici

55 ally (and hence microscopically) similar but genetically altered human colon cancer cell lines, HT29

56 methods to generate and propagate normal and genetically altered human hematopoietic cells are increa

57 te human melanocytic neoplasia and show that genetically altered human tissue facilitates functional

58 sess tactile and thermal hypersensitivity in genetically altered (i.e., TLR4 knockout and point-mutan

59 By contrast, bioluminescence imaging of genetically altered immortalized esophageal cells reveal

60 r cell surface expression in response to the genetically altered immune environment to evade host rec

61 betes, the underlying metabolic effects of a genetically altered immune system are poorly understood.

62 naling pathways and processes that were each genetically altered in 67 to 100% of the tumors.

63 otein in the development of cancer, as it is genetically altered in a large number of sporadic human

64 , including IKZF1, TCF3, EBF1, and PAX5, are genetically altered in a large portion of the human B-li

65 ity that has not previously been found to be genetically altered in any human cancer.

66 To determine whether PIK3CA is genetically altered in brain tumors, we performed a larg

67 , nine do not contain genes previously shown genetically altered in cancer, whereas the remaining 13

68 TGF-beta receptors and Smads have been found genetically altered in certain human cancers, no mutatio

69 delta anion was genetically altered in cultured dorsal root ganglion neu

70 The PI3K pathway is genetically altered in excess of 70% of breast cancers,

71 Using T cell-specific murine lines genetically altered in expression of p38alpha, and mice

72 Although IRF4 is not genetically altered in most myelomas, they are nonethele

73 en reported of both PKMTs and PRMTs that are genetically altered in specific human cancers, and in se

74 ines of the wild tobacco Nicotiana attenuata genetically altered in specific well-characterized defen

75 , we have analyzed tumor development in mice genetically altered in the genes for fibronectin or alph

76 Mice genetically altered in the IGF-II system were combined i

77 dopsis mutants (tt4, tt5, and fah1) that are genetically altered in their composition of phenolic com

78 is unknown whether these or other genes are genetically altered in these tumors.

79 majority of these genes were not known to be genetically altered in tumors and are predicted to affec

80 frequency, many of which are not known to be genetically altered in tumors.

81 ements XP-E extracts in vitro, but it is not genetically altered in XP-E patients.

82 pendent upon reciprocal interactions between genetically altered "initiated" cells and the dynamic mi

83 By using genetically altered ion channels as reporters, we were a

84 inase activation states, suggesting that non-genetically altered kinases can be essential "nodes" for

85 explanation for the phenotypes of cells with genetically altered levels of the two dehydratases.

86 melanogaster females that had been mated to genetically altered males that lack sperm and/or Acps.

87 and inflammatory cells in wild-type (WT) and genetically altered mice (ST3Gal-III heterozygotes, Fuc-

88 wever, more recent work-including studies on genetically altered mice and data from microarray analys

89 Using genetically altered mice and E2F4 mutant proteins we dem

90 plied to targeting strategies for generating genetically altered mice and gene therapy.

91 u ligand-binding assays with the analysis of genetically altered mice and in vitro models to demonstr

92 Further studies in genetically altered mice and other models will improve u

93 Both the genetically altered mice and the rats treated with TLR4

94 ion in the microcirculation of wild-type and genetically altered mice by real-time in vivo microscopy

95 In the current studies we used genetically altered mice deficient in MPO to investigate

96 Recent work using genetically altered mice demonstrates that T cell matura

97 Additional experiments using genetically altered mice either deficient in perforin or

98 The growing availability of genetically altered mice has focused attention on the ne

99 Analysis of genetically altered mice has revealed that mutations in

100 The use of genetically altered mice has revolutionised biomedical r

101 Rodent models and genetically altered mice have recently become available

102 Inhibitors and genetically altered mice identify a critical role for es

103 This study used genetically altered mice in an established model of card

104 Using genetically altered mice in which expression of the tumo

105 for induction of focal cerebral ischemia in genetically altered mice include occurrence of subarachn

106 Genetically altered mice including both transgenic and k

107 Genetically altered mice lacking all lymphoid cells due

108 toreceptors in a more direct manner, we used genetically altered mice lacking functional M2 and/or M4

109 By using genetically altered mice lacking specific vesicle-associ

110 Genetically altered mice lacking ZP3 (Zp3(tm/tm)) do not

111 The availability of genetically altered mice may provide a valuable tool for

112 In addition, loss of SNAP-23 using genetically altered mice or shRNA targeted to SNAP-23 le

113 and splenic macrophage (splnMphi) from these genetically altered mice overproduce inflammatory cytoki

114 ort to this model, recent in vivo studies of genetically altered mice question whether ZP3 and/or Gal

115 Subsequent studies in genetically altered mice revealed that NK-cell interfero

116 Application of this model to other genetically altered mice should prove useful for studyin

117 Testing this hypothesis in genetically altered mice showed that the corresponding a

118 Our novel findings in genetically altered mice suggest that activation of the

119 Study of thymocytes from the genetically altered mice suggests that the cause of the

120 ne beta-hydroxylase knockout mice (Dbh(-/-), genetically altered mice that are completely devoid of e

121 ) and CD8(+) T cell-depleting strategies and genetically altered mice that did not express MHC class

122 Liver regeneration studies with genetically altered mice that either prematurely express

123 llagen in the skin, tongue, and esophagus of genetically altered mice that express type VII collagen

124 blood pressure, we engineered a new line of genetically altered mice that lack endothelial angiotens

125 ubtype(s) involved in this activity, we used genetically altered mice that lacked functional M1-M5 mA

126 Here, we review in vivo studies in genetically altered mice that support the notion that mo

127 Cerebral blood flow responses in these genetically altered mice to changes in PO2 demonstrate t

128 We used protein engineering of mouse APC and genetically altered mice to clarify mechanisms for the e

129 Using genetically altered mice to enhance or disrupt extracell

130 We have used genetically altered mice to generate compound functional

131 used a glutamate analog injection model and genetically altered mice to investigate the relationship

132 A utilization observed during heart failure, genetically altered mice were subjected to pressure over

133 These genetically altered mice were used to determine which of

134 B-AR, or alpha2C-AR agonists or antagonists, genetically altered mice were used to identify the molec

135 Genetically altered mice with a selective deletion of th

136 By combining the analysis of genetically altered mice with in vitro models, we demons

137 By combining analysis of genetically altered mice with in vitro models, we show h

138 Genetically altered mice with reductions in the NR1 subu

139 xpressed in cultured epithelial cell models, genetically altered mice, and human mutants.

140 ll, these models, which can be translated to genetically altered mice, are amenable to study with sta

141 Patients, and genetically altered mice, are unable to produce choleste

142 Tissue samples from wild type mice, genetically altered mice, Long Evans rats, and cultured

143 her by a Cdk5-specific inhibitor or by using genetically altered mice, results in increased dopamine-

144 the background strain used to generate most genetically altered mice, the C57BL/6 mouse, is vulnerab

145 aring to study this epileptogenic process in genetically altered mice, we determined whether the back

146 Using genetically altered mice, we identified two innate immun

147 standard for comparison with the retinas of genetically altered mice.

148 rpreting findings derived from studies using genetically altered mice.

149 startle paradigm for assessing cognition in genetically altered mice.

150 udied Eimeria infections of a broad range of genetically altered mice.

151 ic receptor kinase betaARK1) in two types of genetically altered mice.

152 ocorticoids, as demonstrated by infection of genetically altered mice.

153 thymic epithelial cells (TECs) in normal and genetically altered mice.

154 aging to compare area maps in wild type with genetically altered mice.

155 e used two previously characterized lines of genetically altered mice: estrogen receptor-alpha (ER al

156 mined that the same phenomenon occurs in non-genetically altered mice: LSO neurons were 5-HT-immunore

157 nexins was explored using several strains of genetically altered mice: mice with an inactivated Cx32

158 L. pneumophila detection and clearance using genetically altered mouse hosts in which the macrophages

159 Using genetically altered mouse lines with varying degrees of

160 Here, by using the genetically altered mouse melanocytes expressing an endo

161 Genetically altered mouse models constitute unique syste

162 sary to preserve cardiac function, we used 2 genetically altered mouse models that have an attenuated

163 This review focuses on the three genetically altered mouse models that have been the most

164 Using genetically altered mouse models we show that the migrat

165 In this study, we took advantage of 2 genetically altered mouse models with overexpression or

166 s has greatly facilitated the development of genetically altered mouse models.

167 ect pathways in achieving tolerance, we used genetically altered mouse strains in two ways: 1) MHC cl

168 To address these issues, we have employed genetically altered mouse strains that either express th

169 ified by reduced B-cell viability in several genetically altered mouse strains.

170 in which disease phenotypes are assessed in genetically altered murine models of disease.

171 Furthermore, using wild-type and genetically altered murine models of heart failure induc

172 ded in the identification of a population of genetically altered, neoplastic cells in these tumors.

173 on the methods and potential applications of genetically altered nonhuman primates in biomedical rese

174 EGFR is the most common genetically altered oncogene in glioblastoma (GBM), but

175 In tumor cells, genetically altered or abnormally expressed proteins pro

176 PP2A has been shown to be genetically altered or functionally inactivated in many

177 dopsins were expressed in cells expressing a genetically altered PERK protein, Fv2E-PERK.

178 The carrier protein is planned to be genetically altered pertussis toxoid.

179 tment on the retinal structures of mice with genetically altered photoreception.

180 attachment to these cell types, a library of genetically altered pneumococci with defects in exported

181 nuclear magnetic resonance (NMR) analysis of genetically altered polysaccharides.

182 that foci of apocrine metaplasia can share a genetically altered precursor cell with an associated ca

183 e we present a method to selectively isolate genetically altered primary cell cultures based on the p

184 ion spectroscopy and biochemical analysis of genetically altered primases.

185 Prominent examples include genetically altered receptor tyrosine kinases and dysreg

186 Further characterization of this genetically altered region revealed that it represents a

187 Oncolytic viruses are genetically altered replication-competent viruses that i

188 istration of anti-SCF antibodies or by using genetically altered, SCF-deficient mice, inhibits hepato

189 combined immunodeficient (SCID) mice and in genetically altered SCID mice expressing human PDGFRalph

190 The genetically altered strain was found to produce ErA, how

191 relevance of each receptor subtype, we used genetically altered strains of "knock-out" mice lacking

192 LTBMC with genetically altered stromal cells offers an in vitro mod

193 Monitoring genetically altered T cells is an important component of

194 free antigen, local delivery of cytokines by genetically altered T cells, and interference with the f

195 h states have been previously observed for a genetically altered T7 and they are observed here for wi

196 he exchange can be monitored by the use of a genetically altered T7 DNA polymerase (gp5-Y526F) in whi

197 A genetically altered T7 DNA polymerase, T7 polDelta401-40

198 This genetically altered threshold for activation of MRL T ce

199 mpliant titins in a novel mouse model with a genetically altered titin splicing factor; integrative a

200 These studies utilized a yeast strain genetically altered to bypass a deletion of the normally

201 In these studies, we used mice genetically altered to contain no circulating antibody,

202 e, we examined repair in vivo in human cells genetically altered to disrupt or regulate the function

203 osinophilia, IgE production, and AHR in mice genetically altered to express either p31 Ii or p41 Ii i

204 Falpha-knockout (TNFalpha-KO) mice that were genetically altered to express elevated levels of tmTNFa

205 LZ1EBV, a recombinant EBV genetically altered to express LZ1, a derivative of LMP1

206 hain of Fc receptors (FcgammaR(-/-)) or mice genetically altered to lack circulating Ab (J(H)D) with

207 CdtB toxicity is not circumvented in yeast genetically altered to lack DNA damage checkpoint contro

208 The cells genetically altered to overexpress calpastatin display d

209 Additionally, animals genetically altered to overexpress MnSOD showed a signif

210 visiae has large number of genes that can be genetically altered to produce a multiple or pleiotropic

211 s in bone marrow, we assessed mice that were genetically altered to produce osteoblast-specific, acti

212 plantation of myelin-forming cells from pigs genetically altered to reduce the hyperacute response in

213 fic inhibitors and was not detected in cells genetically altered to remove TACE activity.

214 transplantation requires the engraftment of genetically altered totipotent hematopoietic stem cells

215 e by expanding its spectrum of action toward genetically altered tumor cells incapable of apoptosis.

216 Selective targeting of these genetically altered tyrosine kinases has resulted in sig

217 e of direct mutation and discuss whether non-genetically altered tyrosine kinases or their associated

218 A genetically altered vaccinia virus that is unable to rep

219 In parallel experiments, genetically altered VEGF164-deficient (VEGF120/188) mice

220 Recombinant wild-type Hsp27 and a genetically altered version of Hsp27 that is perpetually

221 In the present study we utilized a genetically altered version of M33 (termed R131A) in com

222 ene did not impair the replication of such a genetically altered virus in cultured cells.

223 It is hoped that these genetically altered viruses, in which the hemagglutinin

224 One strategy employs vectors--typically genetically altered viruses--for the delivery of exogeno