ライフサイエンスコーパス: genetically engineered

1 We genetically engineered a Salmonella enterica serovar Typ

2 ol of an arsenic-sensitive promoter, we have genetically engineered a strain that produces increased

3 r phosmet detection in olive oil, based on a genetically-engineered acetylcholinesterase (AChE) immob

4 provide data that mouse models of MDS can be genetically engineered and faithfully recapitulate human

5 As such proteins can be genetically engineered and fused to many biological cell

6 AM composition during gliomagenesis, we used genetically engineered and GL261-induced mouse models in

7 o create biosynthetic excitable tissues from genetically engineered and immortalized HEK293 cells wit

8 ly attach disease-associated autoantigens to genetically engineered and to unmodified red blood cells

9 A chimeric TAT-gelonin fusion protein was genetically engineered, and it displayed remarkably enha

10 l-based assays, ex vivo palate cultures, and genetically engineered animal models have advanced our u

11 Genetically engineered animal models of cancer, where it

12 ian Hydra vulgaris, using calcium imaging of genetically engineered animals to measure the activity o

13 the development and clinical application of genetically engineered antibody-T cell chimeras.

14 and ('donor' neurons) bind to and activate a genetically-engineered artificial receptor on their syna

15 Here, we used cells from human tumors and a genetically engineered autochthonous mouse model of soft

16 Genetically engineered bacteria and reactive DNA network

17 elastomer hybrids that host various types of genetically engineered bacterial cells.

18 semiconducting nanocrystals confined inside genetically engineered bacteriophage P22 VLP using semic

19 contaminated soil is thus possible with this genetically engineered bacterium and could be instrument

20 These data indicate that genetically engineered biosilica frustules may be used a

21 Here, as a proof of concept, genetically engineered BLNs, which display human epiderm

22 adly, we performed an organism-wide study in genetically engineered cancer models using mass cytometr

23 This approach combines the robustness of genetically engineered cancer models with the flexibilit

24 to support expansion and persistence of the genetically engineered cells in vivo.

25 lastin-like polypeptides (ELPs) constitute a genetically engineered class of 'protein polymers' deriv

26 rence screen in primary cell cultures from a genetically engineered, conditional mouse model of aRMS.

27 en globally used in basic plant research and genetically engineered crops (1-4) .

28 ss-resistance threaten the sustainability of genetically engineered crops that produce insecticidal t

29 ed mice with a mixture of wild-type LCMV and genetically engineered CTL epitope-deficient mutant viru

30 A genetically engineered deletion variant of D. hafniense

31 series of adoptive transfer experiments with genetically engineered donors and recipients demonstrate

32 rence in pHCA production yield between three genetically engineered E. coli strains was successfully

33 We have genetically engineered EBV-CTLs to render them resistant

34 p-coumaric acid (pHCA) in the supernatant of genetically engineered Escherichia coli (E. coli) cultur

35 ELP-OPH was simply purified from genetically engineered Escherichia coli based on the uni

36 The genetically engineered fluorescent BTV particles were ob

37 Serratia AS1 was genetically engineered for secretion of anti-Plasmodium

38 icroalgae oil from Phaeodactylum tricornutum genetically engineered for this purpose, as well as tall

39 modern farming, especially as it relates to genetically engineered (GE) crops.

40 Application of genetically engineered (GE) large animals carrying multi

41 For maize genetically engineered (GE) to resist glyphosate herbici

42 m Cell, Zhu et al. (2014) demonstrate that a genetically engineered glioma model displays a functiona

43 atient-derived primary cultures, xenografts, genetically engineered glioma models, or patient samples

44 eth cells (induced by maternal separation or genetically engineered) have intestinal expansion of E c

45 Herein, we used genetically engineered human esophageal keratinocytes an

46 e at its low endogenous expression level, we genetically engineered human pluripotent stem cells (hPS

47 Using genetically engineered human skin tissue in vivo, we dem

48 ety, tolerability, and efficacy of ALD403, a genetically engineered humanised anti-CGRP antibody, for

49 The objective of this study was to employ genetically engineered IGF-II analogs to establish which

50 Ablation of Tpl2 in the genetically engineered in vivo myeloma model, Vkappa*MYC

51 Here, we combined patient-derived and genetically engineered induced pluripotent stem cells (i

52 chimeric antigen receptor" (CAR) which, when genetically engineered into T cells, gives them the capa

53 protein genes of DENV-1, DENV-3, and DENV-4 genetically engineered into the attenuated TDV-2 genome

54 Several attenuation mechanisms have been genetically engineered into the recombinant NDV that red

55 Similar results were obtained in a genetically engineered K-ras(G12D); p53(null) lung cance

56 These genetically engineered K-Ras(V14I)-mutant mice offer an

57 Genetically engineered knock-in (KI) mice containing the

58 Using genetically engineered knock-in reporter mouse lines, he

59 Here, we have used a genetically engineered knockin reporter mouse to map the

60 reatic cancer, next-generation sequencing of genetically engineered Kras-driven mouse pancreatic tumo

61 y on cellular transplantation into mice with genetically engineered liver injury, but these systems i

62 In genetically engineered lung and pancreatic cancer tumour

63 sensor system by utilizing self-assembly of genetically engineered M13 bacteriophage.

64 Students participating in the International Genetically Engineered Machine (iGEM) competition are on

65 ing antitumor immunity in B16 melanoma and a genetically engineered melanoma.

66 The proangiogenic potential of genetically engineered mesenchymal stem cells and endoth

67 In this study, we leveraged Nf1 genetically engineered mice (GEM) to define the potentia

68 Genetically engineered mice (GEMs) have provided valuabl

69 Interfering in this process using genetically engineered mice affects hemostatic and throm

70 rs to metastasis and together with data from genetically engineered mice and experimental metastasis

71 Using a combination of Nf1 genetically engineered mice and pharmacological/genetic

72 various brain regions from nontransgenic and genetically engineered mice and rats can be used, allowi

73 Genetically engineered mice are often used to characteri

74 Here we utilize genetically engineered mice bearing mutations in the A20

75 Genetically engineered mice enable further elucidation o

76 the characterization of an allelic series of genetically engineered mice harboring selective targeted

77 countered in children with NF1, we developed genetically engineered mice harboring two representative

78 Increasing or decreasing Cdk5 activity in genetically engineered mice has severe consequences on T

79 While genetically engineered mice have made an enormous contri

80 Genetically engineered mice have successfully been used

81 Using genetically engineered mice on different diets, we found

82 NF1 patient neural progenitor cells and Nf1 genetically engineered mice to establish, for the first

83 Here, we used genetically engineered mice to investigate the effects o

84 To clarify this issue, we have utilized genetically engineered mice to manipulate the signaling

85 ccination failed until recent experiments in genetically engineered mice were finally successful.

86 In the current study, genetically engineered mice were generated to determine

87 We have generated genetically engineered mice with inactivated Gas2.

88 c-MYC, HER2/neu, Wnt1, or H-Ras oncogenes in genetically engineered mice, correlating it to tumor gro

89 Wild-type (WT) and genetically engineered mice, including T2D mice (db/db),

90 human adenovirus serotype 5 (Ad5) vector and genetically engineered mice, we found that CD8(+) and/or

91 By using genetically engineered mice, we found that IgE ablation

92 Using genetically engineered mice, we found that Rai1 preferen

93 Using genetically engineered mice, we now show that reduction

94 Genetically engineered mice, with human P2X7R, revealed

95 studies that increasingly require the use of genetically engineered mice.

96 tally induced hyperglycemia in wild-type and genetically engineered mice.

97 and when CaMKIIdeltaC is overexpressed as in genetically engineered mice.

98 rimary sarcomas efficiently in wild type and genetically engineered mice.

99 d-test" cycle paradigm, massive libraries of genetically engineered microbes can be constructed and t

100 value-added chemicals.Screening libraries of genetically engineered microbes for secreted products is

101 Genetically engineered microbial biosensors have yet to

102 In a genetically engineered model in which a major full-lengt

103 red to CCR, ICR decreased tumor incidence in genetically engineered models (RR = 0.57; 95% CI: 0.37,

104 While genetically engineered models for malignant rhabdoid tum

105 ours, suggesting that carcinogen-induced and genetically engineered models lead to tumour development

106 Deletion of Mycl in two genetically engineered models of SCLC resulted in strong

107 GF-1 and leptin and increases adiponectin in genetically engineered models.

108 pecies that do not combine well with current genetically engineered models.

109 ment-naive tumors in orthotopic (grafted and genetically engineered) models of HCC.

110 that emerged during a co-clinical trial in a genetically engineered mouse (GEM) model of melanoma tha

111 Despite the utility of current genetically engineered mouse (GEM) models of lung cancer

112 ng cancer and initiate lung tumorigenesis in genetically engineered mouse (GEM) models.

113 ed both in A549 lung cancer cells as well as genetically engineered mouse adenocarcinoma tissues.

114 By using a genetically engineered mouse expressing a G protein-bias

115 tumor growth properties, we first created a genetically engineered mouse line lacking functional Muc

116 verexpression of Muc5ac was also observed in genetically engineered mouse lung adenocarcinoma tissues

117 To this end, we established a genetically engineered mouse model (GEMM) for BRCA1-defi

118 Here, we generated a genetically engineered mouse model (GEMM) of NSCLC drive

119 we characterized the somatic evolution of a genetically engineered mouse model (GEMM) of SCLC initia

120 ate cancer, we generated a new autochthonous genetically engineered mouse model (GEMM) with inducible

121 ion using ultrasound-induced cavitation in a genetically engineered mouse model (KPC mouse) of pancre

122 We used a well-established genetically engineered mouse model (LSL-K-ras(G12D)) of

123 cAMP in gliomagenesis based on results in a genetically engineered mouse model (Nf1 GEM).

124 We generated a PIK3CA genetically engineered mouse model (PIK3CA-GEMM) in whic

125 ine resistance by utilizing tissues from the genetically engineered mouse model and human pancreatic

126 Integrating a genetically engineered mouse model and human prostate ca

127 the early lesion of pancreatic cancer, in a genetically engineered mouse model and in human patient

128 Finally, analyses of tumors from a genetically engineered mouse model and patients show tha

129 rvival, and they offer evidence of the first genetically engineered mouse model for AT/RT in the CNS.

130 To address the issue, we generated a genetically engineered mouse model in which expression o

131 sk neuroblastoma, we generated a MYCN-driven genetically engineered mouse model in which the tamoxife

132 Here, we use a genetically engineered mouse model of BRCA2-associated h

133 6463922 demonstrated antitumor activity in a genetically engineered mouse model of FIG-ROS1 glioblast

134 Here we report the development of a genetically engineered mouse model of gastric adenocarci

135 ls from primary tumors and metastases from a genetically engineered mouse model of human small cell l

136 , and IHCC pathogenesis, and present a novel genetically engineered mouse model of IDH-driven maligna

137 fic alteration of p53 status, we developed a genetically engineered mouse model of localized and meta

138 We investigated Treg cell function in a genetically engineered mouse model of lung adenocarcinom

139 TTM also provided a survival advantage in a genetically engineered mouse model of melanoma, and when

140 umor burdens in syngeneic tumor models and a genetically engineered mouse model of melanoma; to our k

141 In this study, we exploited a robust genetically engineered mouse model of MPNST that recapit

142 In a genetically engineered mouse model of mutant Kras with c

143 dy, we used a tumor cell line derived from a genetically engineered mouse model of PDA to investigate

144 Sensory denervation of a genetically engineered mouse model of PDAC led to loss o

145 Using a lineage-labeled genetically engineered mouse model of PDAC, we found tha

146 Additionally the probe was tested in a genetically engineered mouse model of periostin-expressi

147 ed whether radiotherapy promotes PMT using a genetically engineered mouse model of proneural HGG.

148 In a Tp53; Rb1 deletion genetically engineered mouse model of SCLC, the combinat

149 Here, we demonstrate in a genetically engineered mouse model of soft tissue sarcom

150 exposure of primary cutaneous melanomas in a genetically engineered mouse model promotes metastatic p

151 To visualize TRPV1-lineage axons, a genetically engineered mouse model was used in which a f

152 Notably, patient- and GEMM (genetically engineered mouse model)-derived Hedgehog-dri

153 wed for the sensitive detection of DIPG in a genetically engineered mouse model, and probe uptake cor

154 Alternatively, tumors can be induced in a genetically engineered mouse model.

155 studies were identified, including 11 using genetically engineered mouse models (908 animals with 38

156 dedifferentiation and dissemination both in genetically engineered mouse models (GEMM) and human PDA

157 Preclinical studies using genetically engineered mouse models (GEMM) have the pote

158 Although genetically engineered mouse models (GEMMs) are commonly

159 In genetically engineered mouse models (GEMMs) for Kras-dri

160 Genetically engineered mouse models (GEMMs) have dramati

161 Genetically engineered mouse models (GEMMs) have greatly

162 Genetically engineered mouse models (GEMMs) of cancer ar

163 Genetically engineered mouse models (GEMMs) of Kras muta

164 ies has strained the capacity of traditional genetically engineered mouse models (GEMMs) to provide i

165 can be achieved using organoids derived from genetically engineered mouse models (GEMMs), wild-type o

166 s and a better signal to background ratio in genetically engineered mouse models (GEMMs).

167 ion of Hh pathway activity in three distinct genetically engineered mouse models and found that Hh pa

168 n KRAS mutant tumors has been established in genetically engineered mouse models and human tumor cell

169 In both genetically engineered mouse models and murine xenograft

170 By developing genetically engineered mouse models and primary pancreat

171 that ICR exerts greater anticancer effect in genetically engineered mouse models but weaker cancer pr

172 Conventional genetically engineered mouse models enable the study of

173 Correspondingly, genetically engineered mouse models expressing mutant ID

174 egulated during tumor recurrence in multiple genetically engineered mouse models for breast cancer.

175 Several genetically engineered mouse models have been generated,

176 Genetically engineered mouse models have begun to elucid

177 Studies in genetically engineered mouse models have defined a requi

178 Genetically engineered mouse models have demonstrated th

179 Genetically engineered mouse models have identified mech

180 Using genetically engineered mouse models of breast cancer, we

181 To date, attempts to generate genetically engineered mouse models of colorectal cancer

182 We used genetically engineered mouse models of glioma and quanti

183 Although conventional genetically engineered mouse models of human PDAC have b

184 clinically relevant autochthonous tumours in genetically engineered mouse models of intestinal cancer

185 Here, we show in genetically engineered mouse models of locally induced e

186 PD-L1, which was confirmed in syngeneic and genetically engineered mouse models of lung cancer where

187 respectively, was evaluated in implanted and genetically engineered mouse models of lymphoma and in a

188 uce apoptosis in leukemic cells derived from genetically engineered mouse models of MLL-AF9-driven ac

189 Kras-driven genetically engineered mouse models of non-small-cell lu

190 Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited t

191 nse in KRAS/LKB1-mutant human cell lines and genetically engineered mouse models of NSCLC that develo

192 y significantly inhibited tumor formation in genetically engineered mouse models of pancreatic cancer

193 We used genetically engineered mouse models of pancreatic ductal

194 Genetically engineered mouse models of pancreatic tumori

195 In genetically engineered mouse models of PDA, therapy-indu

196 prostate cancer-associated SPOP mutations in genetically engineered mouse models of SPOP-mutant prost

197 Loss of EphA2 function in both human and genetically engineered mouse models of TNBC reduced tumo

198 Genetically engineered mouse models that employ site-spe

199 the clinical features of NF1 and the use of genetically engineered mouse models to define the molecu

200 ible lentiviral systems, tumor initiation in genetically engineered mouse models, and gene-targeting

201 In genetically engineered mouse models, ESCC high periostin

202 In xenograft and genetically engineered mouse models, the WDR4/PML axis e

203 Comparing different genetically engineered mouse models, we found that expre

204 Using genetically engineered mouse models, we show that hepato

205 Using genetically engineered mouse models, we show that hetero

206 equired for TSC mesenchymal tumorigenesis in genetically engineered mouse models.

207 of prostate cancer, including cell lines and genetically engineered mouse models.

208 ografts as well as PDAC and PanIN lesions in genetically engineered mouse models.

209 against skin carcinogenesis was examined in genetically engineered mouse models.

210 ing technologies for detection of PDAC using genetically engineered mouse models.

211 F1 in DM1 pathogenesis is well studied using genetically engineered mouse models.

212 In extant genetically engineered mouse prostate cancer models (GEM

213 yroid gland epithelial cells and a series of genetically engineered mouse strains as model systems to

214 adic PA are currently under development, Nf1 genetically-engineered mouse (GEM) models have served as

215 bination of complementary in vitro and novel genetically-engineered mouse strains in vivo to determin

216 tionally, we leveraged two complementary Nf1 genetically-engineered mouse strains in which hippocampa

217 ce, we have previously developed several Nf1 genetically-engineered mouse strains that form optic gli

218 e evaluated the anticancer efficacies of the genetically engineered MSCs in vitro and in vivo by usin

219 Using genetically engineered murine liver models, we show that

220 This makes genetically engineered murine models a more attractive p

221 ired metastatic locations) isolated from two genetically engineered murine models of OS.

222 While cell lines, genetically engineered murine models, and xenografts hav

223 ferentiation into macrophages in vitro Using genetically engineered murine pre-B cells that secrete d

224 including patient-derived xenograft and the genetically engineered mutant KRAS-driven lung cancer mo

225 Genetically engineered neural stem cell (NSC) transplant

226 Here, we present a genetically engineered NF2 mouse model generated through

227 metastatic angiosarcoma independent of other genetically engineered oncogenes or tumor suppressor los

228 Using well-characterized genetically engineered oral and esophageal human epithel

229 To address this challenge, we propose using genetically engineered "organ niches" in large animals t

230 sive overview of preclinical models covering genetically engineered organisms, models of transplantat

231 of this study was to evaluate the impact of genetically engineered OX3097D-Bol olive fly on three no

232 examine these selective forces in vitro, we genetically engineered P. falciparum to express geograph

233 hese barriers, we developed a platform using genetically engineered Pichia pastoris strains designed

234 al groups have reported extended survival of genetically engineered pig organs in nonhuman primates,

235 Developing genetically engineered probiotics holds great promise as

236 ltage-sensing domains with the brightness of genetically engineered protein fluorophores.

237 their structural and functional properties, genetically engineered protein-based hydrogels have emer

238 To accomplish this, genetically engineered proteins were previously required

239 Using genetically engineered PTEN-deficient cell lines, we dem

240 With a genetically engineered pulse of GATA-binding protein 6 (

241 escribe recent progress for approaches using genetically engineered receptors that selectively intera

242 are tethered covalently and specifically to genetically engineered receptors.

243 s, fluctuations are typically assessed using genetically engineered reporter cell lines that produce

244 In this study, we show that a genetically engineered RSV-F-encoding adenoviral vector

245 uld allow rational design of next generation genetically engineered self-healing structural proteins.

246 ated from their mothers as newborns and mice genetically engineered (Sox9(flox/flox)-vil-cre on C57BL

247 The recent development of methods and genetically engineered strains allowed the description o

248 We used genetically engineered strains of mouse norovirus (MNV)

249 in mouse models has traditionally relied on genetically-engineered strains made via transgenesis or

250 ere incubated with RBC isolated from various genetically engineered swine or from humans.

251 To address this possibility, we introduced a genetically engineered switch receptor construct, compri

252 Genetically engineered T cells are powerful new medicine

253 Adoptive immunotherapy with genetically engineered T cells has the potential to trea

254 The adoptive transfer of genetically engineered T cells with cancer-targeting rec

255 sue of Blood, Mamonkin and colleagues report genetically engineered T cells with specificity for the

256 iet (HFD) induced diabetic mouse model and a genetically engineered T2DM rat model.

257 As a step toward this goal, we genetically engineered the aerobic bacterium Caulobacter

258 We genetically engineered the P. putida KT2440 with stable

259 In this study, we have successfully genetically engineered the segmented RNA genome of bluet

260 pancreatic ductal epithelial cells (PDECs), genetically engineered to allow time-specific expression

261 e describe a novel model of SFTS in hamsters genetically engineered to be deficient in a protein that

262 Mice genetically engineered to be humanized for their Ig gene

263 The phage is genetically engineered to become fluorescent and capable

264 ging of MDA-MB-231 human breast cancer cells genetically engineered to brightly express membrane-targ

265 On the other hand, platelets have been genetically engineered to correct inherited bleeding dis

266 The diatom Thalassiosira pseudonana is genetically engineered to display an IgG-binding domain

267 is question, we monitor yeast cells that are genetically engineered to display error-prone transcript

268 Yeast cell lines were genetically engineered to display Hepatitis C virus (HCV

269 Adoptive transfer of CD8 T cells genetically engineered to express "chimeric antigen rece

270 lycogen synthase-3beta inhibitor TWS119, and genetically engineered to express a CD19-specific chimer

271 ucted a clinical trial of allogeneic T cells genetically engineered to express a chimeric antigen rec

272 nistering autologous CD4(+) T cells that are genetically engineered to express an MHC class II-restri

273 T cells genetically engineered to express CARs can specifically

274 Similar to T-cells genetically engineered to express chimeric antigen recep

275 lactis, a non-pathogenic bacteria, has been genetically engineered to express the III7-10 fragment o

276 which is the optical stimulation of neurons genetically engineered to express the light-gated ion ch

277 , are replication-competent viruses that are genetically engineered to induce selective cancer cell l

278 Bacteria can be genetically engineered to kill specific pathogens or inh

279 Most mice genetically engineered to lack both TrxR1 and GR in all

280 on across the entire cerebral cortex in mice genetically engineered to lack the hem.

281 infusion of bone marrow-derived macrophages genetically engineered to overexpress murine MCAD marked

282 he following: Live bacterial sensor strains, genetically engineered to produce a dose-dependent amoun

283 They may be genetically engineered to produce new compounds such as

284 thalamic stem/progenitor cells that had been genetically engineered to survive in the ageing-related

285 They can be genetically engineered to target nanoparticles, cells, t

286 able nanoparticles that can be chemically or genetically engineered, to be used as platforms for mult

287 iggered dramatic regression in an aggressive genetically engineered tumor model.

288 To bridge ACT with a pathogen, we genetically engineered tumor-specific CD8 T cells in vit

289 based on the adoptive transfer of natural or genetically engineered tumor-specific T cells and discus

290 Oncolytic viral (OV) therapy, which uses genetically engineered tumor-targeting viruses, is being

291 Pig fetal fibroblasts were genetically engineered using Cas9 and guide RNAs, and cl

292 A human monocytic cell line was genetically engineered using lentivirus RNA interference

293 Rab3gap1 (-/-) and Rab18 (-/-) mice were genetically engineered using standard approaches, wherea

294 n which endogenous MerTK was replaced with a genetically engineered variant that is cleavage-resistan

295 genera, Plasmodium and Toxoplasma, until we genetically engineered viable parasites lacking AMA1.

296 for producing and administering high-purity genetically engineered virus-specific T cells that are r

297 Here we report the self-assembly of genetically engineered viruses (M13 phage) into target-s

298 We find that iNSCs genetically engineered with optical reporters and tumour

299 YLLIP2 was produced by genetically engineered Y lipolytica and purified from cu

300 mpacts presynaptic release by establishing a genetically engineered zebrafish line in which we can fr