ライフサイエンスコーパス: genetically modified

1 tably, also unstimulated T cells were stably genetically modified.

2 cal, organic, grass-fed, farmed/wild, or non-genetically modified.

3 Using a genetically modified algal strain capable of secreting e

4 he presence of those dark states in both the genetically modified and the wild-type light harvesting

5 HSCs) can be safely collected from the body, genetically modified, and re-infused into a patient with

6 has greatly improved the ability to generate genetically modified animal models of human diseases.

7 future uses of this knowledge for generating genetically modified animal models permissive for these

8 Genetically modified animal models with reduced dopamine

9 By using genetically modified animal models, pharmacologic inhibi

10 rs in situ in combination with sophisticated genetically modified animal models, together with bioche

11 tudies of presymptomatic, at-risk cases) and genetically modified animal models.

12 tools have revolutionized the generation of genetically modified animals including livestock.

13 The generation of genetically modified animals is important for both resea

14 y transferred to assess their persistence in genetically modified animals lacking distinct lung APC s

15 We also present a new method to isolate genetically modified animals using engineered selection

16 perimental results obtained in vitro or with genetically modified animals with human disease.

17 mice from different genetic backgrounds and genetically modified animals with in silico and in vitro

18 To generate genetically modified animals, CRISPR/Cas9-mediated genom

19 re powerful strategies for the generation of genetically modified animals.

20 s conceptually similar to that obtained from genetically modified animals.

21 tial for exciting new cellular therapy using genetically modified anti-CD19 CAR T cells and discuss i

22 These genetically modified antigen-presenting cells expanded C

23 Gene silencing produced two genetically modified apple lines expressing Mal d 1.02 a

24 Clinical responses to the genetically modified apples were compared to those seen

25 Here we report the construction of a genetically modified ASFV-G strain (ASFV-G-Delta9GLv) ha

26 In the past, genetically modified ASFVs harboring deletions of virule

27 on ASFV virulence lead to the production of genetically modified attenuated viruses that induce prot

28 Therapy with genetically modified autologous T cells has shown great

29 We used both wild-type and genetically modified B. burgdorferi s. l. bacteria, reco

30 The use of live, genetically modified bacteria as delivery vehicles for b

31 ng note of caution on the employment of live genetically modified bacteria for the delivery of biolog

32 terization of the quorum-sensing response of genetically modified bacteria in the presence of a wide

33 ng MDA-MB-468 or HT1080 xenografts and using genetically modified BALB/neuT mice, which spontaneously

34 of lignin to enhance yields of biofuels from genetically modified biomass.

35 s of reduced Brd1 expression, we generated a genetically modified Brd1(+/-) mouse and subjected it to

36 Human HAP1 and A549 cells were genetically modified by clustered regularly interspaced

37 MSCs are genetically modified by transfection with the mms6 gene

38 ated immune responses to PVM in a variety of genetically modified C57BL/6 mice.

39 These cells, if genetically modified, can be used as vehicles to deliver

40 Using genetically modified cancer cells that only express p47,

41 avoidance of the undesired rendering of the genetically modified CD8 T cells susceptible to HIV infe

42 he oxygen sensing pathway using a variety of genetically modified cell and mouse lines.

43 ified with ethyl esters preferentially label genetically modified cells that express a substrate-sele

44 reas its activation can promote apoptosis in genetically modified cells.

45 ion, the demonstrated safety and activity of genetically modified chimeric antigen receptor (CAR) T c

46 ng these passenger mutations to the reported genetically modified congenic mice that were generated u

47 vitro models allow the investigation of the genetically modified counter-regulator of motoneuron tox

48 acterial source can be useful for developing genetically modified crops and can function similarly to

49 and examines the potential of microalgae and genetically modified crops as future sources of these im

50 ed the micropropagation of elite hybrids and genetically modified crops, but the mechanism responsibl

51 loss of milkweed resources for larvae due to genetically modified crops, pesticides, and fertilizers;

52 nt intensity, climate change, pesticides and genetically modified crops, pollinator management and pa

53 ormal mice observing excessive scratching in genetically modified demonstrator mice.

54 ional assay exhibits detection capability of genetically modified DNA below sub-nanomolar level and i

55 Furthermore, genetically modified Dnmt2-only mouse embryonic stem cel

56 y increased reprogramming efficiencies using genetically modified donor cells, prospectively isolatin

57 The biorecognition element, genetically modified E. coli overexpressing either cyclo

58 Clinical-grade T cells are genetically modified ex vivo to express chimeric antigen

59 type females, whereas wild-type males prefer genetically modified females.

60 Using genetically modified fibroblasts from p14-deficient mice

61 What consumers don't know about genetically modified food, and how that affects beliefs.

62 Genetically modified foods are a major concern around th

63 us polarization regarding nanotechnology and genetically modified foods.

64 With a genetically modified form of the flavoenzyme TrmFO as a

65 the foundation for production of an array of genetically-modified FPs for in vitro biosensors capable

66 of photoswitch ligands and the complementary genetically modified GABA(A) receptor subunits.

67 grouped into three different categories: (i) genetically modified, glyphosate-tolerant soy (GM-soy);

68 ctants (PIPs) are biopesticides expressed in genetically modified (GM) crops and are typically macrom

69 Compositional analysis of genetically modified (GM) crops continues to be an impor

70 Because the number and diversity of genetically modified (GM) crops has significantly increa

71 With the large-scale release of genetically modified (GM) crops, there are ecological co

72 ain, there are calls to reopen the debate on genetically modified (GM) crops.

73 food supplements were found positive for the genetically modified (GM) elements P-35S and T-nos.

74 ation of Aquadvantage(R) GM salmon on future genetically modified (GM) fish to be commercialized.

75 In the debates surrounding biotechnology and genetically modified (GM) food, data from consumer polls

76 Despite heated debates over the safety of genetically modified (GM) food, GM crops have been expan

77 sure Standard requires a mandatory label for genetically modified (GM) food.

78 Glyphosate tolerant genetically modified (GM) maize NK603 was assessed as 's

79 the tissue microenvironment, via the use of genetically modified (GM) mice or agents such as antibod

80 d feed additives result from fermentation of genetically modified (GM) microorganisms.

81 Premarket, genetically modified (GM) plants are assessed for potent

82 There is concern that genetically modified (GM) plants may have adverse affect

83 drive the expression of phytotoxic BP100 in genetically modified (GM) rice.

84 Genetically modified (GM) technique, one of the modern b

85 th both type 1 and type 2 viruses, pigs were genetically modified (GM) to possess one of the followin

86 osum L. cv. Desiree) tubers, which have been genetically modified (GM) to reduce glycoalkaloid conten

87 was a key target for researchers engineering genetically modified (GM) tomatoes in the 1990s, but onl

88 R, gene drives, RNAi, synthetic biology, and genetically modified [GM] insects and fish), provide a p

89 nvestigated the use of CHC to protect WT and genetically modified (GTKO.hCD46.hTBM) pig aortic endoth

90 Transplantation of genetically modified hematopoietic stem cells (HSCs) is

91 ent donors and autologous transplantation of genetically modified hematopoietic stem cells, are curre

92 We genetically modified hESCs to specifically demarcate acq

93 Compared to methods that require genetically modified histones, our DNase-based approach

94 In mice, HO-1 overexpression by genetically modified HO-1 macrophage therapy was accompa

95 py, involving the transplantation of ex vivo genetically modified HSPCs are complex and not without r

96 Gene therapy with genetically modified human CD34(+) hematopoietic stem an

97 Using genetically modified human cells that are deficient in D

98 l cell cultures, including the production of genetically modified human neural progenitor cells (hNPC

99 y based on epitope mapping data to develop a genetically modified hypoallergenic variant showing prot

100 Recent studies using genetically modified IgE reporter mice indicate that the

101 BR/08 was the most pathogenic in genetically modified immunocompromised mice [BALB scid a

102 Replacement of wild insect populations with genetically modified individuals unable to transmit dise

103 Several chemically or genetically modified insulins have been developed that t

104 Quo (2) by measuring the calcium response in genetically modified Jurkat T-cells under varying ligand

105 After generating a genetically modified knock-in (KI) mouse having a glycin

106 Genetically modified laboratory strains of Saccharomyces

107 Genetically modified Lactococcus lactis, non-pathogenic

108 Previously, we have shown that genetically modified Leishmania donovani parasites, here

109 tronic spectroscopy with the availability of genetically modified light harvesting complexes, to reve

110 We manipulated plant resistance using genetically modified lines of tomato (Solanum lycopersic

111 aturally occurring, cell culture-adapted, or genetically modified live attenuated ASFV.

112 erimental vaccines have been developed using genetically modified live attenuated ASFVs where viral g

113 Our data show that genetically modified live attenuated Ldp27(-/-) parasite

114 Previously, we showed that genetically modified live-attenuated Leishmania donovani

115 are currently undergoing testing, including genetically modified live-attenuated parasite vaccines.

116 ntibiotic resistance-conferring plasmids and genetically modified lytic phages.

117 Thus, genetically modified macrophages serve as a highly effic

118 ese changes result in a mating preference of genetically modified males for wild-type females, wherea

119 We used genetically modified mice (germline Npy, Y1, and Y2 rece

120 al, high-frequency region of the cochleae of genetically modified mice (including models of human her

121 Mechanistic studies were carried out using genetically modified mice and depletion of lymphocyte su

122 nation of intravital multiphoton microscopy, genetically modified mice and novel in vivo homing assay

123 he value of screening platelet phenotypes of genetically modified mice and shed further light upon th

124 Consistent with the human data, the genetically modified mice displayed significantly more e

125 annulating collecting lymphatic vessels from genetically modified mice for ex vivo study.

126 Sharp tuning in genetically modified mice has been attributed to decreas

127 Although genetically modified mice have provided a great understa

128 nd-healing assay was performed in 3 types of genetically modified mice having various Nur77 activitie

129 Here we describe compound genetically modified mice in which expression of the end

130 distribution of blood flow in the hearts of genetically modified mice is a phenotype of interest bec

131 that, as illustrated here, the real value of genetically modified mice is not as 'models of schizophr

132 we used both pharmacological inhibitors and genetically modified mice models to investigate the iden

133 The study of renal miRNAs, using genetically modified mice or by perturbing endogenous mi

134 Studies employing genetically modified mice point to Hif-2alpha, one of tw

135 escent imaging of kidney sections from these genetically modified mice revealed that RhoA and AQP2 ac

136 Genetically modified mice shed new light on how ketamine

137 vations, altogether with those obtained from genetically modified mice targeting individual CRMPs and

138 f CD103(+) DCs in cGN using several lines of genetically modified mice that allowed us to reduce the

139 ible to follow new blood vessel formation in genetically modified mice that are perinatally lethal.

140 he same disorder, achalasia, was observed in genetically modified mice that express full-length farne

141 In this work, we used genetically modified mice to allow conditional expressio

142 We also used genetically modified mice to define the roles of Chi3l1

143 In this study, we used genetically modified mice to study the light responses a

144 Implications for studies involving genetically modified mice treated with topical agents an

145 Genetically modified mice were developed to selectively

146 Studies with genetically modified mice were performed.

147 ugs acting on the endocannabinoid system and genetically modified mice were used.

148 We then show that genetically modified mice with CARMA3-deficient AECs hav

149 Using genetically modified mice with lung-specific inducible (

150 In genetically modified mice with reduced catechol-O-methyl

151 tes in regulating intact FGF23 production in genetically modified mice without and with adenine-induc

152 By analyzing cell lines, genetically modified mice, and HCC tissues, we found tha

153 cytes freshly isolated from adult rabbits or genetically modified mice, in combination with pharmacol

154 When this technique is applied in genetically modified mice, it enables the investigator t

155 rally evoked symptoms is based on studies on genetically modified mice, the cellular localization of

156 Using genetically modified mice, we addressed the contribution

157 onsistent with this information derived from genetically modified mice, we demonstrated that neutrali

158 During our examination of genetically modified mice, we discovered a series of pro

159 Using genetically modified mice, we found that imiquimod-induc

160 Using genetically modified mice, we found that loss of Id1 inh

161 Using genetically modified mice, we have shown that renal phos

162 Using a combination of genetically modified mice, we show that the coordinated

163 Using genetically modified mice, we systematically examined th

164 r phenotype of liver damage than those using genetically modified mice, with the exception of the chr

165 ospholamban and the ryanodine receptor using genetically modified mice.

166 Wild type and genetically modified mice.

167 central to the cardiovascular phenotyping of genetically modified mice.

168 es to inflammatory sites was investigated in genetically modified mice.

169 The latter are not genetically modified microalgae, but a product of modifi

170 We incorporate information provided by genetically modified models, as well as pre-clinical and

171 Genetically modified mosquitoes are being tested, but th

172 We observed that genetically modified mosquitoes with increased immune ac

173 Generating novel genetically modified mouse and rat models is one valuabl

174 ancer cell lines (D54 and D54-EGFRvIII), and genetically modified mouse astrocytes (wild type, p53-/-

175 The ability to differentiate genetically modified mouse embryonic stem (ES) cells int

176 In this study, we used a genetically modified mouse line carrying the fat-1 gene

177 overy following a burn injury, we utilized a genetically modified mouse model (Pax7(CreER) -DTA) that

178 Here, we used a genetically modified mouse model and human patient data

179 Premature aging is studied in a genetically modified mouse model with an age-dependent a

180 nisms of severe PAH and identified the first genetically modified mouse model with obliterative vascu

181 Using a genetically modified mouse model, we recently verified t

182 We found that 58% of articles involving genetically modified mouse models did not completely add

183 The proliferation of genetically modified mouse models has exposed phenotypic

184 ne the interaction of these factors, we used genetically modified mouse models of mammary-specific p5

185 Here we use several genetically modified mouse models to demonstrate that ex

186 was tested in mechanistic studies using two genetically modified mouse models with either constantly

187 Genetically modified mouse models, expressing higher or

188 en-induced arthritis by using PGRN and IL-10 genetically modified mouse models.

189 Here we show, in a humanized genetically-modified mouse model of pancreatic ductal ad

190 For therapeutic purposes, we first genetically modified MSCs to stably express a panel of f

191 In addition, genetically modified mutant activated PC, with a high af

192 unogenic after a single, human-range dose in genetically modified MV-susceptible mice.

193 By generating genetically modified newborn mice that specifically lack

194 However, the spatiotemporal dynamics of non-genetically modified (non-GM) crops are not clear, altho

195 proposed method, we show detection of WT and genetically modified nonhalotolerant cells (Salmonella t

196 Mice (genetically modified or bone marrow-derived mast cell-re

197 lization, spectral properties and absence in genetically modified or drug-treated mice.

198 Mostly used genetically modified or tumor-prone models are less reli

199 l vaccines derived from naturally occurring, genetically modified, or cell culture-adapted ASFV have

200 Considering the needs for genetically modified organism (GMO) traceability in high

201 real sample environment of extracted DNA of Genetically Modified Organism products.

202 ld-type ACT1 promoter.Genetic isolation of a genetically modified organism represents a useful strate

203 We illustrate our method on genetically modified organism, inhibition, dynamic range

204 eter for the detection and quantification of genetically modified organisms (GMO's) using the polymer

205 Presence of genetically modified organisms (GMO) in food and feed pr

206 Cultivation of genetically modified organisms (GMOs) and their use in f

207 The CRMs available in the field of genetically modified organisms (GMOs) are characterized

208 Genetically modified organisms (GMOs) are commonly used

209 Genetically modified organisms (GMOs) are increasingly d

210 Genetically modified organisms (GMOs) are increasingly u

211 Because no artificially constructed genetically modified organisms (GMOs) are introduced int

212 coming years, the frequency of unauthorised genetically modified organisms (GMOs) being present in t

213 EU regulations on the mandatory labeling of genetically modified organisms (GMOs) with a minimum con

214 ed by NBTs do not fall under the umbrella of genetically modified organisms (GMOs), their commerciali

215 s to expedite the computational detection of genetically modified organisms (GMOs).

216 Discrimination of genetically modified organisms is increasingly demanded

217 The present studies and the availability of genetically modified organisms with altered outer membra

218 Genetically Modified Organisms, have been entered our fo

219 r, and prevention of environmental escape by genetically modified organisms.

220 have low allergenicity and do not come from genetically modified organisms.

221 SPR/Cas9 systems) into embryos, for creating genetically modified organisms.

222 osafety Research (ISBR) focused on so-called genetically modified organisms.

223 eering cellular behaviour without exploiting genetically modified organisms.

224 risks evoked by microorganisms, allergens or genetically modified organisms.

225 Genetically modified PAEC significantly prolonged clotti

226 potential interventions, and propagation of genetically modified parasites.

227 Mathematical modelling and probing of genetically modified pathways revealed that the simple f

228 onstrated for two tobacco plant varieties, a genetically modified plant and its corresponding wild-ty

229 The fatty alcohol fractions from the genetically modified plants are acetylated to mimic the

230 In some cases, this might require the use of genetically modified plants when R genes cannot be intro

231 roduction of any moth pheromone component in genetically modified plants.

232 Here, we developed a genetically modified porcine model of cancer in which an

233 suggesting that pre-transplant perfusion of genetically modified porcine organs with CHC may benefit

234 These findings were made in genetically modified primary human T cells and have a cl

235 Using a genetically modified rabies virus, we demonstrated that

236 After establishing the first genetically modified rat model linked to BMPR2 mutations

237 This allowed creation of genetically modified rats in a work-, cost-, and time-ef

238 f antioxidants between the wild-type and the genetically modified raw tomatoes were confirmed, but an

239 ding ASFV virulence led to the production of genetically modified recombinant viruses that, while att

240 (PNA) probe specific for a gene tract of the genetically modified Roundup Ready soy.

241 o digestion model, showed an increase in the genetically modified samples.

242 on intracellular signaling cascades by using genetically modified sensor cells based on the human ker

243 Here, we show that the genetically modified soybean oil Plenish, which came on

244 We genetically modified specific subunits with negatively c

245 Genetically modified spheroids with lentiviruses can be

246 By using genetically modified stem cells and specific inhibitors,

247 We previously reported that a genetically modified strain of Mycobacterium smegmatis c

248 dy the biology of the RPE from wild-type and genetically modified strains of mice between the ages of

249 of cell-cell interactions on IIF using three genetically modified strains of the mouse insulinoma cel

250 s that can preferentially target GSCs; thus, genetically modified strains that further optimize safet

251 often require specific markers or the use of genetically modified systems, making it difficult to det

252 le and cost-effective approach to developing genetically modified T cells can be used to implement cl

253 Genetically modified T cells expressing chimeric antigen

254 Genetically modified T cells expressing chimeric antigen

255 Genetically modified T cells expressing engager molecule

256 Purpose Adoptive transfer of genetically modified T cells is being explored as a trea

257 vely transferred back to the individual, the genetically modified T cells will hopefully provide dura

258 in 2,200- to 2,500-fold ex vivo expansion of genetically modified T cells, with 84% CAR expression, a

259 noviral infection before reconstitution with genetically modified T cells.

260 We genetically modified the Plasmodium falciparum K13 locus

261 Genetically modified TMV VLPs express both surface attac

262 ally have low levels of uric acid, with mice genetically modified to accumulate high levels of uric a

263 vestigated the competitiveness of mosquitoes genetically modified to alter expression of their own an

264 al gene silencing (PTGS), the TRV2 genome is genetically modified to carry a fragment of the target g

265 Yeast cells were genetically modified to display both single chain variab

266 Adoptive transfer of T cells genetically modified to express a cancer-specific T-cell

267 adoptive transfer of T cells that have been genetically modified to express a CD19-specific chimeric

268 T cells can be genetically modified to express an anti-CD19 chimeric an

269 such area where recent trials using T cells genetically modified to express an antibody-based chimer

270 Adoptive transfer of T cells genetically modified to express chimeric antigen recepto

271 Adoptive transfer of T cells genetically modified to express chimeric antigen recepto

272 Purpose T cells genetically modified to express chimeric antigen recepto

273 Autologous stem cells that have been genetically modified to express dystrophin are a possibl

274 virus, Epstein-Barr virus, or adenovirus and genetically modified to express HER2-CARs with a CD28.ze

275 ultiple myeloma (MM) with autologous T cells genetically modified to express kappa.CAR (kappa.CARTs).

276 cently developed method in which neurons are genetically modified to express membrane proteins sensit

277 n between platelets and CTCs, platelets were genetically modified to express surface-bound tumor necr

278 dependent cardiomyopathy (CCM) by using mice genetically modified to feature elevated SR Ca(2+) leak

279 a1 is a novel target in testis that could be genetically modified to improve the bioavailability of F

280 paBbeta/NF-kappaB signaling, as well as mice genetically modified to overexpress IkappaBbeta, we show

281 hines in a virulent Shigella flexneri strain genetically modified to produce minicells capable of int

282 us indicating that a single regulator can be genetically modified to promote growth rate and reproduc

283 Adoptive immunotherapy with T cells genetically modified to recognize tumors is a promising

284 veral different lepidopteran insect pests in genetically modified tobacco and other plants.

285 Genetically modified, transgenic hyperfibrinogenic (HFg)

286 Using genetically modified (TT305/6VA and T305D) mice, we iden

287 ects induced in both naturally occurring and genetically modified tumor-infiltrating lymphocytes (TIL

288 be engineered to enter B-cell follicles, we genetically modified unselected CD8 T cells to express C

289 his cytotoxic effect gammadelta T cells were genetically modified using a lentiviral vector encoding

290 T cells were genetically modified using DNA plasmids from the SB plat

291 ted a human application of T cells that were genetically modified using the Sleeping Beauty (SB) tran

292 This study investigated interactions between genetically-modified vaccinia virus (GLV-1h68) and radio

293 Genetically modified variants of the null mutant line we

294 Using this genetically modified virus, we were able to vaccinate sw

295 ic vaccinees could result in introduction of genetically modified viruses into sustainable tick-verte

296 sults highlight the significant potential of genetically modified VLPs as selective nanostructured pr

297 T cells genetically modified with the Sleeping Beauty system to

298 ologous CD4 T cells, 11 to 28% of which were genetically modified with the ZFN.

299 replicate in monkey erythrocytes and can be genetically modified with unprecedented efficiency, prov

300 sm for studying development and disease, and genetically modified zebrafish provide an essential tool