ライフサイエンスコーパス: genetics

1 was detected, indicating a limited effect of genetics.

2 jor landmarks of late 20th century molecular genetics.

3 asets is central in facilitating advances in genetics.

4 y, is a fundamental quantity in evolutionary genetics.

5 ons plays a fundamental role in evolutionary genetics.

6 ve traits (QTs) is one major task in imaging genetics.

7 nsertion collection with traditional forward genetics.

8 functions via peptide treatment and reverse genetics.

9 ging from disease gene mapping to speciation genetics.

10 All constructs were recovered by reverse genetics.

11 story, genealogy, forensics and male medical genetics.

12 ime pointing to remarkable complexity in CHD genetics.

13 It is an important concept in breeding and genetics.

14 T and CD8(+) T cells are more influenced by genetics.

15 stress is known to be influenced by sex and genetics.

16 endelian disease is a major unknown in human genetics.

17 the etiology of Alzheimer's disease by human genetics.

18 experiments to solve a difficult problem in genetics.

19 Yeast is a powerful model for systems genetics.

20 rome Association International Consortium on Genetics (511 total).

21 Using high-throughput genetics, 5560 minigene molecules were assayed for splic

22 classified using American College of Medical Genetics (ACMG) consensus guidelines.

23 Population genetics analysis demonstrates that the Korean populatio

24 In this report, using molecular genetics, analytical chemistry, and mass spectrometry an

25 Integrated evaluation of baseline genetics and assessment of minimal residual disease are

26 Combining metabolomics, plant genetics and biochemical approaches, we show that transg

27 Neuron, Cho et al. (2017) use advanced mouse genetics and biochemical experiments to unravel the liga

28 Building on decades of research using genetics and biochemistry, unprecedented quantitative in

29 had an exceptional impact on fields such as genetics and cancerous mutation detection Here we report

30 quires supporting data from both statistical genetics and clinical genomics.

31 ion, land-use and habitat surveys, molecular genetics and demographic and spatial modelling to analys

32 These findings demonstrate that both host genetics and diet can influence the microbial communitie

33 rical perspective on the progress made in MS genetics and discuss current work geared towards creatin

34 monstrates the complementarity of population genetics and ecological niche modeling in understanding

35 data sets: the Epidemiological Study on the Genetics and Environment of Asthma (EGEA) data set (1660

36 ts of the EGEA (Epidemiological study of the Genetics and Environment of Asthma, bronchial hyperrespo

37 Although leukocyte subsets are influenced by genetics and environment, adaptive immune traits are mor

38 bial communities are influenced by both host genetics and environmental factors.

39 Aging, genetics and environmental toxicity are important etiolo

40 us be used to rapidly take a snapshot of the genetics and epigenetics of each specific human centrome

41 owever, little is known about the population genetics and evolutionary forces underlying the invasive

42 In 2015, the American College of Medical Genetics and Genomics (ACMG) and the Association for Mol

43 dge on disease aetiopathogenesis and outline genetics and genomics approaches that are helping cataly

44 Ultimately, the strength of imaging genetics and genomics lies in their translational and in

45 Imaging genetics and genomics research has begun to provide insi

46 rget-specific oligonucleotides, which limits genetics and genomics research on many species.

47 rsity Resource (CeNDR) to enable statistical genetics and genomics studies of C. elegans and to conne

48 practical prospects for the use of landscape genetics and genomics to understand the biology and cont

49 rous researchers working in various areas of genetics and genomics.

50 Host genetics and hormonal changes associated with the menstr

51 Growing availability of data on pathogen genetics and human ecology, coupled with computational a

52 ne essentiality has applications in clinical genetics and may offer insights for drug development.

53 autoimmune diseases for which the underlying genetics and mechanisms are not yet fully understood.

54 f AdoMet analogues in biology research, (epi)genetics and nanotechnology.

55 Genetics and neuropathology strongly link alpha-synuclei

56 We critically review progress in imaging genetics and offer suggestions and highlight potential p

57 ators of these 150 genes, so we used reverse genetics and pharmacologic methods to explore regulation

58 This study describes the impact of crop genetics and processing in two pea lines (Pisum sativum

59 SL and SP cells using a combination of mouse genetics and retrograde labeling.

60 conducted to evaluate distribution, ecology, genetics and secondary chemistry to shed light on factor

61 In periodontitis, genetics and smoking play important roles in host immune

62 Yet, the genetics and structure of LA catabolism have remained un

63 e clearance, whereas patients with high-risk genetics and T-cell acute lymphoblastic leukemia respond

64 ng the mechanisms that link 1-carbon pathway genetics and the condition that we suggest calling, "ast

65 rely on unravelling its pathogenesis through genetics and the development of stem-cell therapy.

66 enrolled in the Childhood Autism Risks from Genetics and the Environment (CHARGE) case-control study

67 eractions and is thus dependent on both host genetics and the extent of virus-mediated HLA-C downregu

68 cal advancements in fields such as molecular genetics and the human microbiome have resulted in an un

69 (2017) examine the relationship between host genetics and the oral microbiome in the context of healt

70 ssible to begin to understand the underlying genetics and to use the new information to begin the eff

71 hlighting the interplay between epigenetics, genetics, and cell-to-cell signaling in cancer, with par

72 antifies the respective effects of age, sex, genetics, and cellular heterogeneity on the interindivid

73 enotype, biological properties, epigenetics, genetics, and clinical associations of human AML LSCs an

74 By integrating nontargeted metabolomics, genetics, and detailed human phenotyping, we identified

75 results from grain quality genomics, systems genetics, and digestibility phenotyping, we propose targ

76 causatively linked to environmental stimuli, genetics, and infection, and a critical current target f

77 of modern chemistry, biochemistry, molecular genetics, and optical physics to these old structures en

78 H9 virus replication was observed by reverse genetics, and recombinant H9N2 viruses with amino acids

79 used to study differential effects of media, genetics, and stress on microbial population growth.

80 ole in multiple genetic diseases, population genetics applications, and forensic casework.

81 Even if WES were performed at the first genetics appointment, there would be an incremental cost

82 A systems genetics approach that interrelates starch structure dat

83 We used a systems genetics approach to elucidate the molecular mechanisms

84 Here, we used a forward genetics approach to investigate the mechanism of arsena

85 To test this, we devised a mouse genetics approach to silence glutamatergic signalling on

86 Using a genetics approach with the double mutants era1 abi1-1 an

87 Using a forward genetics approach, one nonsense and four missense Gmsacp

88 e encountered upon adopting a given chemical genetics approach.

89 ctories and (ii) use quantitative population genetics approaches to estimate the contribution of sele

90 udies in humans and mice, -omics and systems genetics approaches, and unique experimental mouse model

91 cattle genomes and eventually inform future genetics-assisted livestock breeding programs in Russia

92 he phenotypic characteristics and underlying genetics associated with amelanotic melanoma are unknown

93 se study (2007-2010) to explore the recovery genetics at a species' distribution edge.

94 Combining genetics, atomic force microscopy, and immunolabeling, w

95 Thus, testing for BRAF-V600E allows for a genetics-based differential diagnosis between HCL and HC

96 nsequences of the super-Mendelian population genetics before potential applications.

97 Intensive research on the genetics, biochemistry, and biomechanics of this materia

98 effort, leveraging diverse disciplines (from genetics, biochemistry, and immunology to mathematics, c

99 tive Medicine, Asia Pacific Society of Human Genetics, British Society for Genetic Medicine, Human Ge

100 of the pollen season are governed by species genetics, but plant phenology is also influenced by clim

101 ew findings demonstrating that developmental genetics can be used to identify populations of neurons

102 integration of metabolic profiling data with genetics can enhance drug development.

103 Human genetics can help advance the therapeutic enterprise.

104 laboratory mice have demonstrated that host genetics can influence microbial community structure, bu

105 However, factors other than PCa-such as genetics-can impact PSA.

106 ta-analysis Plus the Coronary Artery Disease Genetics (CardiogramplusC4D) consortium's 1000 genomes-b

107 Here we use genetics, cell biological and pharmacological tools to d

108 s "the stem cell of biological disciplines." Genetics, cell biology, oncology, immunology, evolutiona

109 We employ genetics, cell lineage tracing, and single molecule imag

110 rom the Tourette International Collaborative Genetics cohort and a replication sample of 186 trios fr

111 GRAM] plus The Coronary Artery Disease [C4D] Genetics; combined total 66 842 cases), stroke from META

112 e broader functional genomics and population genetics communities, we developed SNPDelScore, which us

113 their similar size, anatomy, metabolism, and genetics compared to humans.

114 53 CN controls) from the Alzheimer's Disease Genetics Consortium (ADGC), a National Institute on Agin

115 rols from Phase 1 of the Alzheimer's Disease Genetics Consortium (ADGC), providing a polygenic hazard

116 ymorphisms identified by the Type 1 Diabetes Genetics Consortium (T1DGC).

117 al FTD Genomics Consortium, International PD Genetics Consortium and International Genomics of AD Pro

118 mewide association data from the Tobacco And Genetics Consortium and Psychiatric Genomics Consortium.

119 European individuals from the Global Lipids Genetics Consortium in a trans-ancestry meta-analysis.

120 ion, >65 years) from the Alzheimer's Disease Genetics Consortium.

121 ing in songbirds to study how experience and genetics contribute to interindividual differences in le

122 Using a large, multidecade genetics dataset (N = 582 sites, 12,878 individuals) wit

123 g high-resolution approaches combining mouse genetics, designer receptor exclusively activated by des

124 play in depression may benefit from focus on genetics discovered for putative protective factors.

125 cientific advances in the research fields of genetics, disease modelling, biomarkers, and therapeutic

126 mall genome (approximately 800 Mbp), diploid genetics, diverse germplasm, and colinearity with other

127 genetic basis and guide best practices for a genetics-driven approach to early intervention in at-ris

128 milial, has a genetic basis, in which case a genetics-driven approach to identifying at-risk family m

129 Here, we combine behavioral genetics, electrophysiology, and high-speed videography

130 sification system, histopathology, molecular genetics, electrophysiology, and transcriptome and cell

131 Here we use mouse genetics, electrophysiology, imaging and optogenetics to

132 Asia, and Southern African Society for Human Genetics, endorsed the final statement.

133 onment and dynamic interactions between host genetics, environmental factors, and microbes in shaping

134 red young scientists and inspired the age of genetics, epigenetics, and genomics.

135 eive a molecular diagnosis after the initial genetics evaluation, that rate is much lower.

136 integrative approach combining quantitative genetics, expression and diversity data permitted develo

137 Here, we review the human genetics findings coalescing on molecular mechanisms tha

138 argue for a better integration of population genetics findings into malaria-control strategies.

139 specialization of EV-releasing neurons using genetics, fluorescence microscopy, kymography, electron

140 hnology is widely used in the field of mouse genetics for spatial and/or temporal regulation of gene

141 eates a direct phenotypic link between human genetics (G versus A alleles cause Cys529 versus Tyr529

142 Recent developments in genetics, genomics, and computational methods used with

143 rdinary advances in our understanding of the genetics, genomics, biochemistry, and signal diversity o

144 approaches from movement ecology, landscape genetics/genomics and ecoimmunology may provide new aven

145 dvances in the immunology, epidemiology, and genetics/genomics of psoriasis.

146 sed based on the American College of Medical Genetics guidelines.

147 the contemporary American College of Medical Genetics guidelines.

148 The development of molecular genetics has greatly enhanced the study of the biology a

149 Advances in preclinical work and genetics have begun to unravel the molecular architectur

150 Advances in human genetics have dramatically expanded our understanding of

151 roimaging, neuropathology, epidemiology, and genetics have led to a deeper understanding of how vascu

152 rable advances in the understanding of their genetics have led to increased clinical recognition of t

153 Functional neuroimaging genetics holds particular promise for the characterizati

154 International experts in genetics, immunology, metabolism, endocrinology, and sys

155 This study sought to further explore the genetics in a larger set of patients following-up on the

156 Here, by using the power of Drosophila genetics in combination with electrophysiological and be

157 Therefore, the development of genetics in Harpegnathos establishes this ant species as

158 the potential for GWA to complement forward genetics in identifying the genetic basis of ecologicall

159 237 lung cancer cases in the Environment And Genetics in Lung cancer Etiology study, using the Infini

160 owcase the promise of genome-enabled forward genetics in nonmodel species.

161 ches followed by drug optimization, chemical genetics in plant systems tends to be fueled by more gen

162 overview of the current progress in chemical genetics in plants, with a focus on the discoveries rega

163 ed in vitro models to study the role of host genetics in the response of macrophages to this obligate

164 etween seasons, and the role played by viral genetics in viral replication.

165 Brain imaging genetics intends to uncover associations between genetic

166 but little is known about how experience and genetics interact to determine complex learned phenotype

167 For instance, chemical genetics involves the discovery of small-molecule effect

168 s the study of Mendelian and complex disease genetics involving populations of Irish ancestry.

169 Neuroimaging genetics is an emerging field that aims to identify the

170 Neuroimaging genetics is an emerging field that provides a powerful w

171 From early in the study of mammalian genetics, it was clear that modifiers can have a strikin

172 al WES referral tests (N=6517, Baylor Miraca Genetics Laboratories) and compared with a control cohor

173 in the fields of archaeology and population genetics lack either temporal resolution or formal quant

174 is a multifactorial condition influenced by genetics, lifestyle, and environment.We investigated whe

175 he proposed approach contributes to both the genetics literature and the statistics literature, and h

176 workshop assembled international experts in genetics, medical and gynecologic oncology, clinical psy

177 nt with PEGylated medicines, suggesting that genetics might play a role in PEG immunogenicity.

178 A mathematical population-genetics model showed how tolerance boosts the chances f

179 ts of protein dynamics with loss-of-function genetics, mosaic analysis, and temporal control of gene

180 g this hypothesis will help characterize the genetics of 1-carbon pathway metabolism, homocysteine, o

181 develop a discrete time model for population genetics of a drive and proposed genetic countermeasures

182 es drawn from the Collaborative Study on the Genetics of Alcoholism (COGA), we performed a genome-wid

183 asis of a Semi-Structured Assessment for the Genetics of Alcoholism interview.

184 es a more comprehensive understanding of the genetics of alcoholism than previous case-control studie

185 of the incidence, prevalence, phenotype and genetics of ALS and outline the core operating principle

186 lfare, as well as to scientists studying the genetics of animal (including human) behavior.

187 of the current study was to investigate the genetics of antibody responses to an acellular pertussis

188 P1 haplotypes imputed from the International Genetics of AS Consortium (IGAS) Immunochip study were a

189 tudies of Hispanic children: the Puerto Rico Genetics of Asthma and Lifestyle Study (PR-GOAL; n = 306

190 ood Asthma Management Program (CAMP) and the Genetics of Asthma in Costa Rica Study.

191 was to gain new insights into the underlying genetics of body fat distribution by conducting sample-s

192 ans have provided numerous insights into the genetics of both gene expression and complex diseases.

193 hus providing a new paradigm for the complex genetics of CHD.

194 sociation studies allow us to understand the genetics of complex diseases.

195 The genetics of depression has been explored in genome-wide

196 nalysis between longitudinal cohort GoDARTS (Genetics of Diabetes Audit and Research, Tayside Scotlan

197 lected as part of the Yale-Penn study of the genetics of drug and alcohol dependence from February 14

198 pand upon current perspectives regarding the genetics of FA, indicating that FA plays a role in a myr

199 The genetics of general adiposity, as measured by body mass

200 Hu97/18 mice recapitulate the genetics of HD, having two full-length, genomic human HT

201 gulatory variants play a central role in the genetics of human diseases and in evolution.

202 demonstrates the importance of studying the genetics of IBD and other complex diseases in population

203 Our findings provide new insight into the genetics of lean body mass.Lean body mass is a highly he

204 This review discusses the discovery and genetics of LOX-1; describes existing evidence supportin

205 However, the genetics of metastases largely reflects that of the prim

206 dvance in our understanding of the molecular genetics of NCMD and provide insights into the genetic p

207 These data provide new insight into the genetics of neurocognitive function with relevance to un

208 2, advances in understanding the biology and genetics of non-Hodgkin lymphoma and the availability of

209 In contrast, the genetics of NSC is largely unexplored.

210 The molecular genetics of panic disorder (PD) with and without agoraph

211 We thus characterize here the population genetics of previously inaccessible intestinal microbes,

212 stantially enhanced our understanding of the genetics of primary brain tumors by uncovering several n

213 substantial advance in understanding of the genetics of PSC.

214 to date little is known about the underlying genetics of responses to predator-associated risk.

215 Our understanding of the genetics of skin pigmentation has been largely skewed to

216 ensive understanding of the cell biology and genetics of spermatogenesis is difficult for most specie

217 Recent research into risk factors and genetics of stroke has not only identified those at risk

218 To understand the population genetics of structural variants and their effects on phe

219 g] will be critical to dissect the molecular genetics of T2DM pathogenesis, to build next-generation

220 These studies open new avenues in the genetics of TD in humans.

221 escale, evolutionary history, and population genetics of the HIV-1 CRF01_AE strains primarily respons

222 Unraveling the genetics of the paralytic strabismus syndromes known as

223 More importantly, population genetics parameters, for instance, the scaled population

224 om the posterior distributions of population genetics parameters.

225 focused review will describe the underlying genetics, pathophysiology, classification and treatment

226 s (e.g., nonhuman animal models, psychiatric genetics, pharmacologic challenge) to elucidate brain-ba

227 Application of a CRISPR-Cas9 reverse-genetics pipeline enabled insertional mutagenesis of 18

228 al and genetic association studies show that genetics play an important role in the attainment of edu

229 Genetics plays a central role in susceptibility to obesi

230 Genetics plays an important role in accounting for such

231 Genetics plays an important role in the susceptibility t

232 deep metric learning to large-scale chemical genetics projects highlights the utility of this and rel

233 Here, using time-lapse embryonic imaging, genetics, protein-interaction, and functional studies, w

234 Using combined methods of genetics, proteomics and RNA biochemistry, we identified

235 Here we applied molecular genetics, proteomics, and whole-genome sequencing to dem

236 from NGS databases at three large molecular genetics reference laboratories.

237 e 2 diabetes mellitus from DIAGRAM (Diabetes Genetics Replication and Meta-analysis; 34 840 cases), a

238 a cancer therapy, efficient reovirus reverse genetics rescue will accelerate production of recombinan

239 One of the formative goals of genetics research is to understand how genetic variation

240 he importance of including AA populations in genetics research on SUDs and the utility of the endophe

241 f the largest ASD family cohorts, the Autism Genetics Resource Exchange and Autism Genome Project (AG

242 2A E181A mutations into VHSV-IVb via reverse genetics resulted in viruses that replicated efficiently

243 oceanica (NoDGAT2s or NoDGTTs), via reverse genetics, revealed that NoDGAT2A prefers saturated fatty

244 es of mutant influenza viruses using reverse genetics (RG) and selected resistant variants in the pre

245 Transposon-mediated forward genetics screening in mice has emerged as a powerful too

246 ger than 50 years, evaluated by the clinical genetics service at a single tertiary care cancer center

247 outpatient clinics of the Victorian Clinical Genetics Services at the Royal Children's Hospital, Melb

248 In a general clinical genetics setting, the current diagnostic rate is approxi

249 e may vary depending on comorbid conditions, genetics, sex, and other factors.

250 is a user-friendly and efficient population genetics simulator that handles complex evolutionary and

251 We used genetics, single-particle tracking in live cells, superr

252 The Genetics Society of America's Edward Novitski Prize reco

253 British Society for Genetic Medicine, Human Genetics Society of Australasia, Professional Society of

254 In psychiatric genetics specifically, targeting intermediate brain phen

255 onal importance, no large-scale neuroimaging genetics studies have targeted the contributions of gene

256 ithms have been proposed and used in imaging genetics studies.

257 Further neuroimaging genetics study might lead to the development of fundamen

258 due to a paucity of resources for molecular genetics, such as a reference genome.

259 and characterization of a novel ZIKV reverse genetics system based on a 2015 isolate from Puerto Rico

260 ing reovirus rescue from the current reverse genetics system by 100-fold.

261 We developed a reverse genetics system to create a mutant of RRV (RRV(VP4-R446G

262 dy, we employed a helper virus-based reverse genetics system to identify NSP2 gene regions that corre

263 acid mutation at this site through a reverse genetics system.

264 Therefore, the use of reverse genetics systems to engineer viruses lacking NSs is an a

265 Using reverse genetics techniques, we have developed a live-attenuated

266 sources of heterogeneity within psychiatric genetics that can obscure the identification of genotypi

267 ogy, proteomics, genomics, cell biology, and genetics that have propelled new discoveries in the fiel

268 ichment, bioinformatics analysis and reverse genetics that these RNA segments are bound to the coat p

269 facilitated in population and complex-trait genetics, the biology of diseases, and translation towar

270 such as the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) consortium are beginning

271 The Enhancing Neuroimaging Genetics through Meta-analysis (ENIGMA) Consortium is a

272 e associated with the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) findings.

273 mics Consortium (PGC)-Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Gro

274 study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorde

275 To understand better the contribution of genetics to CKD progression, we performed a genome-wide

276 It progresses from genetics to cloning and sequencing to biochemistry to st

277 Here, we use tissue-specific genetics to investigate how sexual size dimorphism (SSD)

278 However, Thompson considered genetics to lie outside the scope of his work, even thou

279 Application of the principles of population genetics to the HLA genes has resulted in the developmen

280 y and Kinship Toolkit (AKT) is a statistical genetics tool for analysing large cohorts of whole-genom

281 A2-IR differed by B-vitamin intake and AS3MT genetics variants.

282 e outside the scope of his work, even though genetics was a growing discipline at the time the book w

283 Using intersectional genetics, we describe the dendritic arbor morphologies o

284 Using reverse genetics, we examined the roles of six selected mutation

285 By using reverse genetics, we found that a single amino acid at position

286 Using reverse genetics, we generated a ToV-PLP knockout recombinant vi

287 Using quantitative genetics, we identify 12 genomic regions that affect par

288 patibility complex-linked systemic sclerosis genetics, we performed genotyping of major histocompatib

289 Here, using in vivo mouse genetics, we show that increasing UBE3A in the nucleus d

290 Here, using NGS and human and mouse genetics, we show that influenza A virus (IAV) ribogenes

291 Using molecular genetics, we then mapped at which point in the regulator

292 clinical trials, diagnosis, management, and genetics were retrieved (reviews, guidelines, clinical t

293 Structure guided design and reverse genetics were used to sequentially transplant larger por

294 n kept under equal conditions and with equal genetics were used.

295 adaptive immune traits are more affected by genetics, whereas innate immune traits are more affected

296 ine this question by intergrating population genetics with ecological niche modelling of Litsea auric

297 has been made in ecological and evolutionary genetics with studies demonstrating how genes underlying

298 and function, combining versatile Drosophila genetics with superresolution microscopy and various fun

299 combines Drosophila melanogaster (fruit fly) genetics with transcriptome analyses it was found that t

300 mber of open questions in human evolutionary genetics would become tractable if we were able to direc