ライフサイエンスコーパス: genome

1 o help functionally annotate the Ae. aegypti genome.

2 etions at 17 sites in four loci of the mouse genome.

3 as Pf EMP1 encoded by up to 60 var genes per genome.

4 a major terminase cleavage site in the phage genome.

5 tr operons that we identified in the S Typhi genome.

6 ealing with the analysis of the morbid human genome.

7 pair coupling events in genes throughout the genome.

8 tion in size and gene content of the plastid genome.

9 epair when oxidized bases are induced in the genome.

10 hase I to ensure faithful inheritance of the genome.

11 ein complex components were deleted from the genome.

12 Rs) are hyper-mutable sequences in the human genome.

13 oviding PIC binding specificity in the human genome.

14 netic diversity under-represented in isolate genomes.

15 ow levels of heteroplasmic variants in their genomes.

16 represent a recombination "hot spot" in CoV genomes.

17 R) and successfully retrieved 19 whole mtDNA genomes.

18 d processing of persistently infecting virus genomes.

19 rogression of ancient MEIs into modern human genomes.

20 fast and affordable sequencing of full human genomes.

21 density of such sequences in other poxvirus genomes.

22 cteria, but 10-fold larger than most plastid genomes.

23 Here, we analyze 563 full genomes, 455 of which are novel, to show that the histor

24 enome of hexaploid wheat (Triticum aestivum, genomes AABBDD) and an important genetic resource for wh

25 obal epigenetic changes occur during zygotic genome activation (ZGA) at the 2-cell stage.

26 -modified maternal mRNAs and impedes zygotic genome activation.

27 Foamy viruses have the largest genomes among mammalian retroviruses and their vectors h

28 However, current whole-genome amplification (WGA) methods are limited by low ac

29 tiation, PGCs must transiently silence their genome, an early developmental process that requires Nan

30 Viral genome analysis indicates unusually low CpG dinucleotide

31 n the prevalence of transposons in the maize genome and dramatic genomic variation driven by transpos

32 ic mechanisms are both tightly linked to the genome and environmentally responsive.

33 nctional protein that encapsidates the viral genome and functions as an adapter between the virus and

34 oth the nature of selection on the influenza genome and the accessibility of specific mutational traj

35 rganisms has been used to annotate the human genome and to increase the understanding of human diseas

36 GWASs) and recent developments in islet (epi)genome and transcriptome profiling (particularly single

37 The high-quality genome and transcriptome provide insight into the green

38 Detailed characterization of plant genomes and genetic diversity is crucial for meeting the

39 (ncRNAs) has expanded our view on mammalian genomes and transcriptomes, as well as their organizatio

40 number of introns observed in annelid mtDNA genomes, and possibly in bilaterians.

41 Functional genome annotation predicts that at least 66 potential PM

42 This updated Arabidopsis genome annotation with a substantially increased resolut

43 of genomic context on replication timing to genome architecture.

44 d highlights unexpected variation in plastid genome architecture.

45 Patient genomes are interpretable only in the context of other g

46 Large structural variations (SVs) within genomes are more challenging to identify than smaller ge

47 viduals are available for comparison or when genomes are sequenced to low coverage.

48 sample tracking and a tool for managing the genome assemblies available to perform an analysis.

49 heir repetitive nature poses a challenge for genome assembly and makes progress on the detailed study

50 Here, we report on a high-quality genome assembly for the K. marmoratus South Korea (SK) s

51 With the completion of The Cancer Genome Atlas (TCGA), there is opportunity for systematic

52 c and gene expression analysis of The Cancer Genome Atlas AML data set reveals that GLI3 expression i

53 on factors (TFs), our analysis of The Cancer Genome Atlas database (TCGA) found that patients with lo

54 genomes, plus an additional 142 strains with genomes available at NCBI.

55 d the assembly quality in terms of reference genome base and gene coverage, transcriptome assembly ba

56 r results suggest that as new regions of the genome become open for transcription during terminal dif

57 that some L1 protein may accompany the viral genome beyond the endosomal compartment.

58 nts are predicted to be present in the human genome, but direct evidence for their biological functio

59 nome Reference Panel (AGRP), the first whole-genome catalogue of variants and phased haplotypes in pe

60 However, the repetitive composition of genomes challenges the identification of target-specific

61 been resolved to chromosomes, and important genome characteristics have not been defined.

62 The genome conservation observed also has implications for t

63 veloped viruses with reverse-transcribed DNA genomes, constitute the family Hepadnaviridae.

64 A single dose of 5 x 10(12) or 2 x 10(13) genome copies of AMT-060/kilogram was administered to 5

65 ) centuries CE) yielded sufficient autosomal genome coverage (0.21x to 3.93x) for population genomic

66 ir, but can result in replication-associated genome damage.

67 onstruct de novo linkage maps on 7-12x whole-genome data on the Red postman butterfly (Heliconius era

68 Here we exploit representative whole-genome data sets from six diverse bacterial species: Sta

69 e extent to which it generates a spectrum of genome diversity(8) or genetically discrete populations(

70 selection, in its various guises, has shaped genome diversity.

71 chanisms in facilitating gene expression and genome duplication and demonstrate that accessory helica

72 ime has been shaped by the most recent whole-genome duplication, which suggests that ancient paralogu

73 landscape following hybridization and whole-genome duplication.

74 Uncoupling these processes through genome duplications likely provided important adaptation

75 rast, it is inherited with half the mother's genome during normal reproduction, a genome that it is r

76 mutation was corrected by CRISPR/Cas9-based genome editing (V247fs-MT-correction).

77 J repair and have important implications for genome editing and genome evolution.

78 This genome editing approach has the advantage that it does n

79 Here we report a genome editing approach in which adeno-associated virus

80 We showed that CRIPSR-mediated genome editing efficiently excised the mutant exon 23 in

81 Genome editing of human induced pluripotent stem cells (

82 Here, we demonstrate that CRISPR/Cas9 genome editing of promoters generates diverse cis-regula

83 As genome editing rapidly progresses toward the realization

84 Then, we discuss how genome editing techniques enable a radically new set of

85 trates the powerful combination of iPSCs and genome editing technologies for understanding the biolog

86 tors that were engineered by CRISPR-mediated genome editing to controllably release GLP-1 (glucagon-l

87 oped osteocytic cell lines-together with new genome editing tools-has allowed a closer look at the bi

88 an enable further optimization of Cas9-based genome-editing specificity and efficiency.

89 fe and efficient delivery of the CRISPR-Cas9 genome-editing system to target cells in human body.

90 The HSV-1 genome encodes numerous proteins that are dedicated to c

91 e, we present a transformational approach to genome engineering of herpes simplex virus type 1 (HSV-1

92 Extracted data were as follows: RNA or DNA genome, enveloped or not, primary transmission pathway,

93 mportant implications for genome editing and genome evolution.

94 4'-OH-2,5-DCB, was then examined using whole-genome expression microarrays (Affymetrix).

95 s Workbench to assemble complete chloroplast genomes for all nine species.

96 hat can cause widespread increase in the pan-genome frequency of genes acquired by horizontal gene ex

97 break (DSB) repair pathway that protects the genome from chromosomal instability.

98 ine de novo transcriptome data and sequenced genomes from an economically important group of grass sp

99 Additionally, the ability to obtain full PV genomes from FTA cards will aid in facilitating global p

100 s study, we sequenced complete mitochondrial genomes from three congeneric Decemunciger (Ampharetidae

101 The Vd991 genome harbored several exclusive, lineage-specific (LS)

102 , generation of datasets from large, complex genomes has been constrained to laboratories.

103 Today, yeast genomes have been very informative about basic mechanism

104 pants to create an open-access repository of genome, health and trait data for research.

105 mproved in GT mice with a vector copy number/genome higher than 1 in the BM and 2 in the thymus.

106 Like many draft genomes, however, the 158-Mb Spirodela genome sequence h

107 e interpretable only in the context of other genomes; however, genome sharing enables discrimination.

108 ated future application for GeneImp is whole-genome imputation based on the off-target reads from dee

109 litate direct analysis of a single infecting genome in a sterile blood specimen are available and hav

110 ends potential involvement of the non-coding genome in its pathogenesis.

111 e of future widespread resequencing of tumor genomes in providing new insights into the contribution

112 to determine the sequence of complete JCPyV genomes in single reads.

113 t of the piRNA pathway and that it maintains genome integrity by silencing transposons.

114 t (transposons) silencing and maintenance of genome integrity.

115 a virus enters a cell transform its packaged genome into an active one.

116 virus to an F-pilus and delivering the viral genome into the host during infection, but how the genom

117 The endosymbiont nuclear genome is 9.5 Mbp in size, the smallest of a kinetoplas

118 The chromatophore genome is about a third the size of the genome of closel

119 ive cells, it is not clear whether the viral genome is also transferred via this mechanism and furthe

120 strains, revealing that a large part of its genome is dedicated to growth.

121 and largely continuous process by which the genome is duplicated.

122 into the host during infection, but how the genome is organized and delivered is not known.

123 need for a strong foundation of high-quality genomes is also discussed, since it underlies all second

124 TSPyV genomes lacked the rearrangements typical for reactivati

125 lication intercross." Chemically synthesized genomes like Sc2.0 are fully customizable and allow expe

126 y members suggests a link between organellar genome maintenance and cell proliferation.

127 ich controls transcription, replication, and genome maintenance in infected cells.

128 retations of many experiments using targeted genome manipulations such as knockouts or transgenics.

129 ARTS allows for specific and efficient genome mining for antibiotics with interesting and novel

130 Currently, complete mitochondrial genomes (mitogenomes) are available from all major land

131 Human mitochondria contain a genome (mtDNA) that encodes essential subunits of the ox

132 The whole-genome mutation landscape of melanoma reveals diverse ca

133 NIKS stably transfected with HPV16 episomal genomes (NIKS16) were compared using next-generation seq

134 We reconstructed the genome of a Chromatiales (class Gammaproteobacteria) bac

135 hore genome is about a third the size of the genome of closely related cyanobacteria, but 10-fold lar

136 tauschii is the diploid progenitor of the D genome of hexaploid wheat (Triticum aestivum, genomes AA

137 The genome of pancreatic ductal adenocarcinoma (PDAC) freque

138 ldimethyl amine (BDMA) was identified in the genome of Pseudomonas sp. BIOMIG1, which is a bacterium

139 Here we analyzed the genomes of 119 strains of the marine actinomycete genus

140 We resequence the genomes of 147 cotton accessions, including diverse wild

141 Here, we analyse the genomes of 155 weedy and 76 locally cultivated rice acce

142 Here we sequence the genomes of an Early and End Neolithic dog from Germany,

143 e being used to access the large and complex genomes of crops and their wild relatives.

144 High-quality genomes of the anaerobic fungi Anaeromyces robustus, Neo

145 Here we describe high-quality draft genomes of these two species and their comparisons at th

146 Sequencing and comparing the genomes of two pathogenic species of Batrachochytrium to

147 The specific infectivities (PFU per viral genome) of HSV(chol) and HSV(des) were similar, suggesti

148 We sequenced whole genomes or a panel of 365 genes on 299 samples from 170

149 ation, promote reprogramming, manipulate the genome, or select functional phenotypes.

150 ome, a finding that helps to resolve nuclear genome organization and indicates monocentric regional c

151 Starting with the 3D genome organization map of LCL, we constructed a compreh

152 insights into the rules governing mammalian genome organization.

153 Relative to the previous reference genome, our assembly features a 52-fold increase in cont

154 Ps transiently incorporated in the mammalian genome per cell cycle.

155 rmed a cgMLST analysis of 92 newly sequenced genomes, plus an additional 142 strains with genomes ava

156 challenges in isolating single cells during genome preparation.

157 A replication results in the doubling of the genome prior to cell division.

158 Advances in genome profiling and next-generation sequencing have led

159 The Personal Genome Project (PGP) is an effort to enroll many partici

160 cing individual's data, validated it on 1000 Genome Project and TCGA data (2700 samples) demonstratin

161 rol and imputation procedures using the 1000 Genomes Project (phase 3) in 12 case-control cohorts com

162 Here we report the Anabaptist Genome Reference Panel (AGRP), the first whole-genome ca

163 are tagged by common SNPs unique to the 1000 Genomes reference panel.

164 All viruses with positive-sense RNA genomes replicate on membranous structures in the cytopl

165 gases enhances LT stability and promotes MCV genome replication.

166 sues, thus are not well-suited for realistic genome-scale applications.

167 We demonstrated that genome-scale fingerprints of an organism can be efficien

168 Through genome-scale integrated analysis of the HIF-alpha networ

169 on of metabolites, reactions and pathways in genome-scale metabolic networks (GEMs) can assist in und

170 draft genomes, however, the 158-Mb Spirodela genome sequence has not been resolved to chromosomes, an

171 ny stable flea cell line or a published flea genome sequence, little is known regarding R. typhi biol

172 haplotypes using reads mapped to a reference genome sequence.

173 Whole-genome sequences of representative highly pathogenic avi

174 Specifically, we utilize 7,444 whole-genome sequences to examine the effect of variants on th

175 Here we use whole-genome sequences to examine the origin and adaptation of

176 ne susceptibility were determined from whole genome sequences.

177 with these outbreaks were analyzed by whole-genome sequencing (WGS) analysis.

178 yndrome, is challenging for short-read whole-genome sequencing (WGS) data.

179 ogy laboratories underwent culture and whole-genome sequencing (WGS), using WGS to identify toxigenic

180 Advances in genome sequencing and assembly are being used to access

181 We used whole-genome sequencing and phylogenetic analysis to investiga

182 d that two were complete denitrifiers, which genome sequencing corroborated.

183 Here using a large whole-genome sequencing data bank, cancer registry and colorec

184 /lymphoma and gastric cancer by human cancer genome sequencing efforts, suggesting both pro- and anti

185 Rapid advances in genome sequencing make it possible to identify multiple

186 apple genome variation map generated through genome sequencing of 117 diverse accessions.

187 address this issue, we carried out 60x whole-genome sequencing of 26 metastases from four patients wi

188 We further performed whole-genome sequencing of nosocomial MDRPa strains to evaluat

189 Whole-genome sequencing of pathogens from host samples becomes

190 The application of single-cell genome sequencing to large cell populations has been hin

191 Here we establish, through fine mapping, genome sequencing, genetic complementation, and gene edi

192 ata types, including exome sequencing, whole-genome sequencing, RNA-seq, ChIP-seq, targeted sequencin

193 q, targeted sequencing and single-cell whole-genome sequencing, with a minimal requirement for sequen

194 drugs, confirmatory Wayne's assay, and whole-genome sequencing.

195 ly in the context of other genomes; however, genome sharing enables discrimination.

196 ning of all publically available V. cholerae genomes showed that numerous strains possess long arrays

197 e with observed positive correlation between genome size and effective population size.

198 Genome size in mammals and birds shows remarkably little

199 and chemotherapeutics, and pose a threat to genome stability and cell survival.

200 uclease 1 is a DNA repair enzyme involved in genome stability and expression of genes involved in oxi

201 L in mitochondrial function, biogenesis, and genome stability has been studied, recent findings indic

202 itosis likely represent important threats to genome stability, but experimental identification of the

203 tion (for double HJ) or resolution to ensure genome stability.

204 n blocks are critical for the maintenance of genome stability.

205 ajor evolutionary forces which can cause new genome structure and species diversification.

206 ncoded by both the nuclear and chromatophore genomes, suggesting that EGT in Paulinella chromatophora

207 le of horizontal gene exchange can result in genome surfing, a mechanism that can cause widespread in

208 To achieve complete Sc2.0 genome synthesis, individual synthetic chromosomes built

209 We enhanced the dCas9-MS2 anchor for genome targeting with Fkbp/Frb dimerizing fusion protein

210 A chloroplast genome that is composed only of linear DNA molecules is

211 other's genome during normal reproduction, a genome that it is relatively compatible with, since the

212 , thereby protecting the integrity of gamete genomes that are passed on to the next generation.

213 ust segregate the replicated copies of their genome to their daughter cells with extremely high fidel

214 tion of genetic material from the organellar genomes to the nucleus.

215 old for virus assembly and as a template for genome transcription and replication.

216 In the human genome, translation initiation from non-AUG codons plays

217 virus type 1 (HSV-1), which has a large DNA genome, using synthetic genomics tools.

218 Here we report an apple genome variation map generated through genome sequencing

219 The number of mitochondrial genomes varies depending on the cell's energy needs.

220 ny years, only a small fraction of the human genome was believed to regulate cell function and develo

221 irst 19 nucleotides (nt) of the rabies virus genome, we demonstrate that L alone initiates synthesis

222 ions in coding and non-coding regions of the genome, we propose CScape, an integrative classifier for

223 The remaining 6 genomes were complex recombinants of 2 or more subtypes,

224 Two distinct nearly full-length Rhizobiales genomes were identified in leaf-pocket-enriched samples

225 mportance of single isolated UMCs across the genome, which is usually not achievable using traditiona

226 Such strategies are effective, but the phage genome-which encodes potentially inhibitory gene product

227 -seq to identify aberrant DNA-binding events genome wide and ectopic transcriptional consequences of

228 sing summary data from the largest RA and AD Genome Wide Association (GWA) and meta-analysis studies

229 ng methylation states are critical to enable genome-wide analyses.

230 predictor can be easily used to conduct the genome-wide analysis and the results obtained are quite

231 In the course of a genome-wide analysis of members of a small family of imm

232 Here, we present a genome-wide analysis of single-nucleotide polymorphism (

233 Genome-wide analysis of the transcribed strand/nontransc

234 shapes traits, especially through the use of genome-wide association (GWA) analyses.

235 lth record (EHR)-based phenotypes allows for genome-wide association analyses in thousands of traits

236 Here, we report the results of genome-wide association analyses of multiple phenotypes

237 Genome-wide association analyses were performed in pedia

238 Using genome-wide association analysis, we identify associatio

239 Multilocus genome-wide association studies (GWAS) have become the s

240 In this review, we discuss how genome-wide association studies (GWASs) and recent devel

241 Genome-wide association studies (GWASs) have identified

242 Recent successes in genome-wide association studies (GWASs) make it possible

243 Combining data from genome-wide association studies from multiple phenotypes

244 Genome-wide association studies have revealed an associa

245 Genome-wide association studies of tumor samples have id

246 We meta-analyzed 2 genome-wide association studies on self-reported allergy

247 Among the participants in the genome-wide association studies, 21 loci jointly influen

248 mmary association results from 7 large-scale genome-wide association studies, we examined the effect

249 tives to the standard univariate analysis in genome-wide association studies.

250 The initial genome-wide association study (GWAS) included 174 Finnis

251 In contrast to genome-wide association study (GWAS), genomic prediction

252 This genome-wide association study analyzed criterion counts

253 Here, the authors perform a genome-wide association study and identify an associatio

254 lymorphisms for schizophrenia in the largest genome-wide association study conducted to date suggeste

255 We conducted meta-analyses of genome-wide association study data on 2080 cannabis-depe

256 We performed the first genome-wide association study for molar shape and used 3

257 A genome-wide association study identified LMO1, which enc

258 om a case and control sample, we conducted a genome-wide association study of usual daily methadone d

259 We also conducted meta-analyses using the genome-wide association study results from the CTD cohor

260 We therefore performed a genome-wide association study with a dimensional, PD/AG-

261 oaches that can be used to test for GxE in a genome-wide association study.

262 i for fiber-quality-related traits through a genome-wide association study.

263 Using genome-wide association, we identified Tnni3k as one gen

264 this study examined longitudinal changes of genome-wide blood DNA methylation profiles in relation t

265 We investigated the impact of genome-wide cardiac DNA methylation on global gene expre

266 each time point demonstrated that changes in genome-wide chromatin accessibility were similar across

267 Genome-wide chromatin immunoprecipitation-sequencing ana

268 developed eight gene association methods for genome-wide coexpression analysis between each TF and al

269 To date, however, no genome-wide comparisons have been performed to provide a

270 Genome-wide correlation studies have revealed that histo

271 build a web-based computational tool for the genome-wide detection of AARS coding sequences.

272 DNA methylation in MS patients, by assaying genome-wide DNA methylation and comparing smokers, forme

273 k scores (PRSs) have successfully summarized genome-wide effects of genetic variants in schizophrenia

274 iction of clinical phenotypes using baseline genome-wide expression data that makes use of prior biol

275 Furthermore, a genome-wide forward screen with Haplobank identified PLA

276 Transcriptome and genome-wide GABP-binding site analyses identify GABP dir

277 The genome-wide investigation of DNA methylation levels has

278 such projects as FANTOM and ENCODE, forming genome-wide landscapes in a series of human cell lines.

279 ouring a BRCA mutation or high percentage of genome-wide loss of heterozygosity.

280 udy, we present the first quantitative human genome-wide map of DNA lesions induced by ultraviolet (U

281 (iPSCs) and hepatocyte-like cells (HLCs) for genome-wide mapping of expression quantitative trait loc

282 Combining genome-wide measures of DNA hydroxymethylation with comp

283 ding gene regulation and function requires a genome-wide method capable of capturing both gene expres

284 ications for T2D, we analyzed and replicated genome-wide protein coding variation in a total of 8,227

285 It is oftentimes unknown, at a genome-wide scale, how much transdifferentiated cells di

286 At the genome-wide scale, our data indicate that ATRX modifies

287 Additionally, we performed a genome-wide scan and identified one SNP with significant

288 nalysis, we identified 22 loci associated at genome-wide significance, including 13 new associations

289 ci associated with emphysema distribution at genome-wide significance.

290 A genome-wide significant association was found between AC

291 AM13A in lung tissue, respectively; and were genome-wide significant in a meta-analysis including bot

292 progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1.12 x 10(-10)) on chr

293 We report 106 genome-wide significant signals that have not been previ

294 lele frequency <0.01, (rs3025380 at DBH) was genome-wide significant.

295 Our high-throughput genome-wide siRNA screen identified host factors that pr

296 Analyzing genome-wide transcription and repair by next-generation

297 Genome-wide transcriptome analysis reveals that lipid bi

298 In this study, we provide the first genome-wide, base pair-resolution map of 6mA in Tetrahym

299 provides accurate annotation of chloroplast genomes without manual intervention.

300 Compensatory roles for global-genome (XPC-1) and transcription-coupled (CSB-1) NER in