1 nickase enzyme that recognizes a 7-bp motif
genome-wide.
2 scrimination against unfavorable AUG context
genome-wide.
3 inter-chromosomal interaction patterns from
genome-wide 3C studies are accurately captured in our mo
4 This revealed the
genome-wide accumulation of mutations in the resistant p
5 Here, we propose SCALE to analyze
genome-wide allele-specific bursting, with adjustment of
6 Genome-wide analyses further revealed global DNA hypomet
7 Collectively, our
genome-wide analyses implicate condensin in the suppress
8 Many cost-effective
genome-wide analyses of DNA modifications rely on restri
9 Recent
genome-wide analyses of human mRNA transcriptome identif
10 ng methylation states are critical to enable
genome-wide analyses.
11 predictor can be easily used to conduct the
genome-wide analysis and the results obtained are quite
12 Genome-wide analysis identified rs2457564 as a variant a
13 Genome-wide analysis of 5-hmC-enriched loci with hmC-sea
14 Through a
genome-wide analysis of DNA methylation across 19 cell t
15 maintenance in CD8(+) T cells, we performed
genome-wide analysis of DNA methylation, histone marking
16 roughput sequencing of diverse tissues and a
genome-wide analysis of Dsx-binding sites.
17 We report
genome-wide analysis of gene expression, DNA methylation
18 In the course of a
genome-wide analysis of members of a small family of imm
19 This result is consistent with a
genome-wide analysis of S. cerevisiae, which reveals tha
20 Here, we present a
genome-wide analysis of single-nucleotide polymorphism (
21 fection, we have carried out a comprehensive
genome-wide analysis of the fitness determinants for gro
22 Genome-wide analysis of the transcribed strand/nontransc
23 Genome-wide analysis shows that nonecotropic replacement
24 -seq to identify aberrant DNA-binding events
genome wide and ectopic transcriptional consequences of
25 We fit this model
genome wide and profile the enzymatic activity of RNA po
26 Using a
genome-wide approach, we demonstrate that inhibition of
27 Genome-wide approaches indicated that LMO2 is required a
28 enes selected for their roles in cancer, and
genome-wide assays that broadly analyze the tumor exomes
29 sing summary data from the largest RA and AD
Genome Wide Association (GWA) and meta-analysis studies
30 As part of a recent
genome wide association study (GWAS) to identify novel l
31 ociation studies and applied them to a large
genome wide association study of BMD.
32 shapes traits, especially through the use of
genome-wide association (GWA) analyses.
33 nd genetic research opportunities, including
genome-wide association (GWA) analysis.
34 Genome-wide association (GWA) studies have identified 19
35 THODS AND Two-sample MR was undertaken using
genome-wide association (GWA) study data.
36 izing 10,422 reference haplotypes to perform
genome-wide association analyses and observe 17 genome-w
37 We performed
genome-wide association analyses for twenty serum biomar
38 lth record (EHR)-based phenotypes allows for
genome-wide association analyses in thousands of traits
39 Here, we report the results of
genome-wide association analyses of multiple phenotypes
40 We report single- and multiple-trait
genome-wide association analyses of self-reported sleep
41 Genome-wide association analyses were performed in pedia
42 Genome-wide association analysis (GWAS) identified genom
43 We conducted a
genome-wide association analysis (GWAS) to identify gene
44 Genome-wide association analysis and replication in 12,5
45 Genome-wide association analysis indicates that all comp
46 We then carried out a
genome-wide association analysis on these traits and the
47 Using
genome-wide association analysis, we identify associatio
48 A5, TYRP1, SMARCA2/VLDLR, and SNX13, using a
genome-wide association approach complemented by targete
49 types has not been tested previously using a
genome-wide association approach.
50 Here we perform a meta-analysis of 11
genome-wide association case-control data sets, totallin
51 Through
genome-wide association discovery in 48,943 individuals,
52 METHODS & Using
genome-wide association meta-analyses in up to 159,940 i
53 onducting sample-size-weighted fixed-effects
genome-wide association meta-analyses in up to 9,594 wom
54 gramplusC4D) consortium's 1000 genomes-based
genome-wide association meta-analysis (N = up to 184305
55 We conducted a
genome-wide association meta-analysis of IOP and optic d
56 otide polymorphisms (SNPs) identified from a
genome-wide association meta-analysis of serum calcium l
57 Previously
genome-wide association methods in patients with classic
58 The urine albumin-to-creatinine ratio
genome-wide association scan identified associations wit
59 Multilocus
genome-wide association studies (GWAS) have become the s
60 During the past decade,
genome-wide association studies (GWAS) have been used to
61 Large-scale meta-analyses of
genome-wide association studies (GWAS) have identified >
62 Previous
genome-wide association studies (GWAS) have identified 1
63 Previous
genome-wide association studies (GWAS) have identified s
64 Genome-wide association studies (GWAS) have not identifi
65 Genome-wide association studies (GWAS) have played an im
66 Genome-wide association studies (GWAS) have transformed
67 bility variants have been identified through
genome-wide association studies (GWAS) of predominantly
68 Most
genome-wide association studies (GWAS) of QT were perfor
69 In comparison to
genome-wide association studies (GWAS), there has been p
70 In this review, we discuss how
genome-wide association studies (GWASs) and recent devel
71 Recent
Genome-wide Association Studies (GWASs) for eye diseases
72 Genome-wide association studies (GWASs) have identified
73 A meta-analysis of
genome-wide association studies (GWASs) identified multi
74 Genome-wide association studies (GWASs) implicate the PH
75 Recent successes in
genome-wide association studies (GWASs) make it possible
76 etic predictors of inflammatory markers from
genome-wide association studies and applied them to a la
77 proved mmLD method will be useful for future
genome-wide association studies and genetic association
78 NPs) on the panel from previous studies, and
genome-wide association studies by using FarmCPU R packa
79 Interpretation of results from
genome-wide association studies for T2D is challenging.
80 Combining data from
genome-wide association studies from multiple phenotypes
81 Genome-wide association studies have identified at least
82 Genome-wide association studies have implied the associa
83 Genome-wide association studies have revealed an associa
84 Genome-wide association studies identified numerous dise
85 Recent
genome-wide association studies identified over 100 gene
86 Genome-wide association studies in frontotemporal dement
87 We explored
genome-wide association studies of chronic lymphocytic l
88 193 CpGs with an enrichment of signals from
genome-wide association studies of lipid levels (PTC=0.0
89 Most
genome-wide association studies of this trait have been
90 Genome-wide association studies of tumor samples have id
91 We meta-analyzed 2
genome-wide association studies on self-reported allergy
92 ntified 14,059 segregating polymorphisms and
genome-wide association studies revealed 28 GWAS hits in
93 Among the participants in the
genome-wide association studies, 21 loci jointly influen
94 proximately 4200 common variants reported in
genome-wide association studies, approximately 1000 de n
95 s (SNPs), the most common genetic markers in
genome-wide association studies, are usually in linkage
96 entifying response-associated genes in large
genome-wide association studies, the results have been f
97 mmary association results from 7 large-scale
genome-wide association studies, we examined the effect
98 P (rs964184) for triglycerides identified by
genome-wide association studies.
99 were associated with 100 genetic loci using
genome-wide association studies.
100 tives to the standard univariate analysis in
genome-wide association studies.
101 AAA risk loci using data from all available
genome-wide association studies.
102 case-control status have been replicated by
genome-wide association studies.
103 ntial heritability not explained by previous
genome-wide association studies.
104 The initial
genome-wide association study (GWAS) included 174 Finnis
105 ther fields in terms of gene discovery using
genome-wide association study (GWAS) methods.
106 s of hippocampal structure here we perform a
genome-wide association study (GWAS) of 33,536 individua
107 We conducted a
genome-wide association study (GWAS) of alcohol consumpt
108 Biobank sample (N=108 976), we carried out a
genome-wide association study (GWAS) of responses to the
109 Based on our initial
genome-wide association study (GWAS) on esophageal squam
110 A
genome-wide association study (GWAS) predicted additiona
111 The majority of
genome-wide association study (GWAS) risk variants resid
112 In contrast to
genome-wide association study (GWAS), genomic prediction
113 A
genome-wide association study across all VNB isolates re
114 This
genome-wide association study analyzed criterion counts
115 Here, the authors perform a
genome-wide association study and identify an associatio
116 lymorphisms for schizophrenia in the largest
genome-wide association study conducted to date suggeste
117 We conducted meta-analyses of
genome-wide association study data on 2080 cannabis-depe
118 We performed the first
genome-wide association study for molar shape and used 3
119 We performed a
genome-wide association study for VTE with approximately
120 d then validated significant SNPs in another
genome-wide association study from Harvard University.
121 Using data from a published
genome-wide association study from The University of Tex
122 A
genome-wide association study identified LMO1, which enc
123 This multicohort
genome-wide association study identified new genomic loc
124 We performed a
genome-wide association study in 1001 healthy participan
125 onses to an acellular pertussis vaccine by a
genome-wide association study in mice.
126 We conducted a cross-disorder
genome-wide association study meta-analysis to identify
127 From a
genome-wide association study of 16,596 individuals of E
128 In a
genome-wide association study of 19,219 individuals, we
129 ci underlying LBM, we performed a gene-based
genome-wide association study of lean mass index (LMI) i
130 om a case and control sample, we conducted a
genome-wide association study of usual daily methadone d
131 We also conducted meta-analyses using the
genome-wide association study results from the CTD cohor
132 s applied to two large Caucasian and Chinese
genome-wide association study summary datasets of bone m
133 We conducted an exploratory
genome-wide association study to identify single-nucleot
134 Genotyping, imputation, and
genome-wide association study were performed at each stu
135 We therefore performed a
genome-wide association study with a dimensional, PD/AG-
136 Through a
genome-wide association study, we report the identificat
137 oaches that can be used to test for GxE in a
genome-wide association study.
138 i for fiber-quality-related traits through a
genome-wide association study.
139 Using
genome-wide association, we identified Tnni3k as one gen
140 We report significant
genome-wide associations at 14 loci.
141 None of our loci overlapped with
genome-wide associations for asthma, although one locus
142 In this study, we provide the first
genome-wide,
base pair-resolution map of 6mA in Tetrahym
143 this study examined longitudinal changes of
genome-wide blood DNA methylation profiles in relation t
144 lity of aneuploid fetuses is affected by the
genome-wide burden of slightly deleterious variants.
145 Here, we examine the
genome-wide,
C(5) -Methyl-cytosine (m5C) methylome and i
146 We investigated the impact of
genome-wide cardiac DNA methylation on global gene expre
147 The prion form caused
genome-wide changes in the transcriptome.
148 elucidating drug resistance mechanisms using
genome-wide chemical mutagenesis allied to next-generati
149 each time point demonstrated that changes in
genome-wide chromatin accessibility were similar across
150 Genome-wide chromatin immunoprecipitation-sequencing ana
151 rformed on an Illumina platform, followed by
genome-wide chromosomal copy number variation profiling
152 developed eight gene association methods for
genome-wide coexpression analysis between each TF and al
153 To date, however, no
genome-wide comparisons have been performed to provide a
154 Genome-wide correlation studies have revealed that histo
155 We have assembled
genome-wide data from 19 ancient individuals, including
156 search and service groups to analyze typical
genome-wide datasets being generated by H3Africa researc
157 build a web-based computational tool for the
genome-wide detection of AARS coding sequences.
158 aviolet radiation, revealing their nonrandom
genome-wide distribution.
159 ese same habitats, we also found significant
genome wide DNA methylation differences.
160 DNA methylation in MS patients, by assaying
genome-wide DNA methylation and comparing smokers, forme
161 We tested for association between
genome-wide DNA methylation in WBCs and total IgE levels
162 Genome-wide DNAm profiles in individuals with CHARGE and
163 ynamics, massive accumulation of DNA damage,
genome-wide double-strand breaks enriched at Ssb-binding
164 k scores (PRSs) have successfully summarized
genome-wide effects of genetic variants in schizophrenia
165 e predictions of the GNM correlate well with
genome-wide experimental measurements.
166 iction of clinical phenotypes using baseline
genome-wide expression data that makes use of prior biol
167 Genome-wide expression of lncRNAs and mRNAs was determin
168 Because of their
genome-wide expression patterns in a variety of tissues
169 Fine mapping analysis by integration with
genome-wide expression QTLs (eQTLs) from the same BC pop
170 We found that approximately 50% of
genome-wide expression variability is explained by varia
171 Furthermore, a
genome-wide forward screen with Haplobank identified PLA
172 e results show that cohesin has an essential
genome-wide function in mediating long-range chromatin i
173 Here we developed a
genome-wide functional screen to interrogate the transcr
174 Transcriptome and
genome-wide GABP-binding site analyses identify GABP dir
175 We used
genome-wide gene expression analysis in clinical samples
176 Here, we use an unbiased
genome-wide genetic screen in near-haploid human cells t
177 A
genome-wide genetic structure analysis of southern Afric
178 We compiled publicly available
genome-wide genotype data on 5,966 individuals from 282
179 s with established psychiatric diagnoses and
genome-wide genotype data.
180 Here, we integrated
genome-wide genotype, gene expression, viremia level, an
181 Genome-wide genotypes were imputed to the 1000 Genomes r
182 Using
genome-wide haploid genetic screens, here we identify th
183 oposed a random regression model to estimate
genome-wide imprinting effects on the relative growth of
184 ch colocalizes with histone H3K4 methylation
genome-wide in human cells, mouse embryonic stem cells,
185 owing us to map autonomous promoter activity
genome-wide in K562 cells.
186 However, the
genome-wide intensity of this selection is not exception
187 We performed
genome-wide interaction analyses between genetic variant
188 The
genome-wide investigation of DNA methylation levels has
189 pressed in the polarized tissues, leading to
genome-wide Irx3(+) caudal-polarization signals.
190 such projects as FANTOM and ENCODE, forming
genome-wide landscapes in a series of human cell lines.
191 We conducted a
genome-wide linkage and association study in three Europ
192 Candidate gene and
genome-wide linkage studies have not significantly contr
193 ouring a BRCA mutation or high percentage of
genome-wide loss of heterozygosity.
194 l single-guide RNA libraries, we conducted a
genome-wide loss-of-function genetic screen in an isogen
195 udy, we present the first quantitative human
genome-wide map of DNA lesions induced by ultraviolet (U
196 nce-driven saturation mutagenesis revealed a
genome-wide map of the genetic determinants of plant roo
197 ortance of 5hmU, we develop a method for the
genome-wide mapping of 5hmU-modified loci based on a che
198 (iPSCs) and hepatocyte-like cells (HLCs) for
genome-wide mapping of expression quantitative trait loc
199 At both time points the
genome-wide mapping reveals that there is significant co
200 Genomic selection (GS) uses
genome-wide markers as an attempt to accelerate genetic
201 We present a
genome-wide measurement of the order of splicing within
202 Combining
genome-wide measures of DNA hydroxymethylation with comp
203 ding gene regulation and function requires a
genome-wide method capable of capturing both gene expres
204 s single nucleotide polymorphisms (SNPs) and
genome-wide methylation (methylation quantitative trait
205 We characterize
genome-wide methylation and highlight conserved motifs a
206 Here, we compare
genome-wide methylation patterns between isogenic ESC an
207 Genome-wide methylation profiles for different clones wi
208 we used a systems approach of integrating a
genome-wide miRNA screen with patient-derived phospho-pr
209 ere low, relative to the large difference in
genome-wide mismatching between the 2 groups.
210 Here, we identify extensive
genome-wide modification of sites bearing the active his
211 different inbred mouse strain to examine the
genome-wide nuclear DNA methylation and gene expression
212 portunity to customize the classification of
genome-wide nucleotide variant data most relevant to bio
213 Genome-wide occupancy mapping and transcriptome profilin
214 Moreover, the results from the
genome-wide off-target assessments, compared with other
215 duces epigenetic reprogramming, by comparing
genome-wide patterns of methylation and variation at the
216 rithms and conservation scores: including 13
genome-wide prediction algorithms and conservation score
217 enie (LEG), a collection of highly accurate,
genome-wide predictions of enhancers in the developing l
218 Genome-wide profile analysis revealed that genes regulat
219 ications for T2D, we analyzed and replicated
genome-wide protein coding variation in a total of 8,227
220 Our method is unbiased and scans a
genome-wide protein-protein interaction network using a
221 n to the standard exome capture, we included
genome-wide proximal promoter regions that contain seque
222 In
genome-wide rate comparison studies, there is a big chal
223 and physical distances was examined and the
genome-wide recombination rate was found to be much smal
224 We develop
Genome-wide Reconstruction of Complex Structural Variant
225 of hundreds of enhancers along with drastic
genome-wide reduction of HNF4A and HNF4G occupancy.
226 We examined
genome-wide regulatory actions of ZNF764 on the glucocor
227 next-generation sequencing (NGS) to generate
genome-wide repair maps.
228 iduals) and from the Coronary Artery Disease
Genome-wide Replication and Meta-analysis Plus the Coron
229 Recent
genome-wide ribosome profiling studies suggest that thou
230 Our
genome-wide RNA compendium will allow for a better under
231 Here we have carried out the first
genome-wide RNA-Sequencing study in human conjunctival f
232 Here, we use a
genome-wide RNAi-synthetic lethal screen and transcripto
233 The interpretation of these
genome-wide ROIs represents a challenge as the majority
234 At a
genome-wide scale estimation of correlation matrices can
235 It is oftentimes unknown, at a
genome-wide scale, how much transdifferentiated cells di
236 At the
genome-wide scale, our data indicate that ATRX modifies
237 Additionally, we performed a
genome-wide scan and identified one SNP with significant
238 We performed 2 high-density,
genome-wide scans comprising 2345 cases of African Ameri
239 -dimensional image analysis, combined with a
genome-wide screen for DELLA-bound loci in the infloresc
240 We test the model's predictions with a
genome-wide screen for essential genes using a transposo
241 igh-fidelity DNA replication, we conducted a
genome-wide screen in Saccharomyces cerevisiae using DNA
242 rfering with cyclins/CDKs, we performed nine
genome-wide screens for human microRNAs (miRNAs) directl
243 PRko, CRISPRi and CRISPRa) in the context of
genome-wide screens to identify components that influenc
244 es the research community with wild strains,
genome-wide sequence and variant data for every strain,
245 We performed
genome-wide sequencing and analyzed mRNA and miRNA expre
246 Taking advantage of recent advances in
genome-wide sequencing approaches, Vo ngoc and colleague
247 Genome-wide sequencing data has enabled modern phylogeno
248 described in v78 (September 2016), combining
genome-wide sequencing results from 28 366 tumours with
249 Recent
genome-wide sequencing studies have identified frequent
250 ogramming-induced senescence, we performed a
genome-wide shRNA screen in primary human fibroblasts ex
251 Two new signals were observed at
genome-wide significance (P < 5 x 10-8), namely, rs72160
252 No associations reached
genome-wide significance (p>5 x 10(-8)).
253 212 is noteworthy (FPRP <0.2) and approaches
genome-wide significance in multivariable analysis (P mu
254 rs2075291, in APOA5 associated with CAD at a
genome-wide significance level and provided new insights
255 not identified maternal sequence variants of
genome-wide significance that replicate in independent d
256 No associations of
genome-wide significance were detected for CD.
257 An SNP near integrin alpha6 (ITGA6) reached
genome-wide significance with PA (P=1.80x10(-8)), wherea
258 This approach identified 13 new loci at
genome-wide significance, 12 of which were on our previo
259 Three variants in locus ADAM12 achieved
genome-wide significance, although they did not replicat
260 nalysis, we identified 22 loci associated at
genome-wide significance, including 13 new associations
261 c analysis, which was underpowered to detect
genome-wide significance, the evaluation being limited t
262 iated with both leucine and valine levels at
genome-wide significance.
263 adjusted lung function, and 15q25.1 reached
genome-wide significance.
264 ci associated with emphysema distribution at
genome-wide significance.
265 In our meta-analyses, 1
genome-wide significant association was detected: the ca
266 A
genome-wide significant association was found between AC
267 AM13A in lung tissue, respectively; and were
genome-wide significant in a meta-analysis including bot
268 ssociated with a functional variant that was
genome-wide significant in our meta-analysis.
269 morphism (SNP) in TRACK-HD (rs557874766) was
genome-wide significant in the meta-analysis (p=1.58 x 1
270 Near
genome-wide significant interaction effect was observed
271 The identification and characterization of
genome-wide significant loci for cannabis dependence is
272 -stratified analysis identified 2 additional
genome-wide significant loci in females.
273 We identified four
genome-wide significant loci, none of which showed any a
274 The authors identified one
genome-wide significant locus on chromosome 12 (rs462230
275 progression in TRACK-HD and REGISTRY gave a
genome-wide significant signal (p=1.12 x 10(-10)) on chr
276 a linear mixed model, identified three novel
genome-wide significant signals on chromosomes 2, 11, an
277 We report 106
genome-wide significant signals that have not been previ
278 on are associated with greater enrichment in
genome-wide significant SNPs from the GWAS catalog, and
279 ome-wide association analyses and observe 17
genome-wide significant, independent signals, including
280 lele frequency <0.01, (rs3025380 at DBH) was
genome-wide significant.
281 Our high-throughput
genome-wide siRNA screen identified host factors that pr
282 Genome-wide studies utilizing STARR-seq identified two e
283 A recent large-scale
genome-wide study from our group predicted transcription
284 Additionally,
genome-wide surveillance of inherited SVs reveals novel
285 A
genome-wide survival analysis of 14,406 Alzheimer's dise
286 s for locating cis-regulatory modules (CRMs)
genome-wide,
the next pressing challenge is to assign pr
287 Here, using
genome-wide transcription and genetic diversity analyses
288 Analyzing
genome-wide transcription and repair by next-generation
289 Genome-wide transcription factors (TFs) binding data has
290 a overexpression substantially recapitulates
genome-wide transcriptional profiles and alternative spl
291 Although
genome-wide transcriptome analysis on diseased tissues h
292 Genome-wide transcriptome analysis reveals that lipid bi
293 ll regions of sequence and do not illustrate
genome-wide trends, or are complicated to use and create
294 By monitoring recombination
genome-wide using cytological assays and at hotspots usi
295 ble us to quantify methylation stochasticity
genome-wide using Shannon's entropy, associating it with
296 Genome-wide variation in P. leucopus indicates two post-
297 associated with AF, but the contributions of
genome-wide variation to AF susceptibility have not been
298 landraces and wild species, we characterize
genome-wide variation.
299 (117 g L(-1)), and L2 (76 g L(-1))-to gain a
genome-wide view of the mechanism of citrate accumulatio
300 ntial to limit gene conversion tract lengths
genome-wide,
without affecting crossover formation.