ライフサイエンスコーパス: genomewide

1 dentified DNA sequences to which it is bound genomewide.

2 the embryo drives gene expression phenotype genomewide.

3 chromatin structure and transcription levels genomewide.

4 In these studies, we developed and applied a genomewide adapter-mediated emulsion PCR amplification p

5 Recent genomewide analyses have identified a high frequency of

6 Genomewide analyses identified a panel of Bach1 target g

7 We performed genomewide analyses of 293 lower-grade gliomas from adul

8 In this report, our comprehensive, genomewide analyses of AGO4- and AGO6-dependent DNA meth

9 Genomewide analyses of the mammalian transcriptome have

10 Genomewide analysis confirmed the self-proclaimed racial

11 Genomewide analysis demonstrated significant evidence of

12 re, employing RNA sequencing, we performed a genomewide analysis of cellular responses triggered by V

13 This has allowed, for the first time, a genomewide analysis of coiled-coil evolution.

14 We performed TP53 mutation analysis and genomewide analysis of loss of heterozygosity and alleli

15 A genomewide analysis of protein-coding nested gene pairs

16 and computationally efficient algorithms for genomewide analysis of quantitative trait loci (QTL) for

17 tuberculosis infection were identified from genomewide analysis of RNA expression in host blood.

18 Genomewide analysis showed that F. tularensis LVS underg

19 GC>TT/AA) occur in sperm but not in cancers; genomewide analysis showed that this same mutation is al

20 Recent advances in computational biology and genomewide analysis, integrated with diverse experimenta

21 are strongly deleterious to cells that have genomewide and constitutive H3 K56 hyperacetylation.

22 tion in vivo, we measured histone H3 density genomewide and found that it was reduced at promoters in

23 riched promoters of actively expressed genes genomewide and that H3K4 methylation is important for ZF

24 er this question, we performed plastome- and genomewide array analyses in the pap7-1 mutant of Arabid

25 on sequencing (Tn-seq) system for performing genomewide assessment of gene fitness in GBS.

26 events that initiate pairing, we performed a genomewide assessment of the zygotic contribution to thi

27 signature genes in a recently completed AMD genomewide association (GWA) data set revealed that TIMP

28 ication of genomic loci that had significant genomewide association (P<5.0x10(-8)) or an association

29 Regional and genomewide association analyses were performed to search

30 Genomewide association analysis and fine mapping by homo

31 Genomewide association analysis showed that SNP rs284457

32 Genomewide association and epigenetic studies found a re

33 Mendelian randomization using summary level genomewide association data from the Tobacco And Genetic

34 We also tested for genomewide association in an independent cohort of 917 p

35 ed genetic diversity may have advantages for genomewide association mapping in disease genetics.

36 Genomewide association mapping in model organisms such a

37 thods to control for population structure in genomewide association mapping of complex traits, but sy

38 Genomewide association meta-analysis studies have identi

39 ARHGEF3, which was previously implicated by genomewide association meta-analysis studies in bone cel

40 patients who did not have a response in the genomewide association sample.

41 ational Consortium for Blood Pressure (ICBP) genomewide association studies (>69,000 participants) us

42 Genomewide association studies (GWAS) are being conducte

43 eases, to attempt to replicate findings from genomewide association studies (GWAS) for childhood asth

44 leles for human behavioral disorders through genomewide association studies (GWAS) has been hampered

45 ritis, with particular emphasis on published genomewide association studies (GWAS).

46 Genomewide association studies (GWASs) of asthma have id

47 omatin-based functional genomic analyses and genomewide association studies (GWASs) together implicat

48 Current genomewide association studies account for only a small

49 We reported two genomewide association studies and four case-control stu

50 Modern genomewide association studies are characterized by the

51 Genomewide association studies are now a widely used app

52 Genomewide association studies can be used to identify d

53 nalysis of rs75932628 genotypes imputed from genomewide association studies confirmed this associatio

54 ent, and so far, only positional cloning and genomewide association studies have been used to study t

55 rphisms (SNPs) identified and characterized, genomewide association studies have begun to identify su

56 Recent genomewide association studies have found multiple genet

57 Genomewide association studies have identified dozens of

58 Genomewide association studies have identified multiple

59 Epidemiologic and genomewide association studies have linked loss-of-funct

60 Genomewide association studies have shown a relation bet

61 Although genomewide association studies have successfully identif

62 Genomewide association studies identified ORMDL3 as a pl

63 Genomewide association studies implicate the 'alarmin' I

64 oteins has been recently linked to asthma in genomewide association studies in humans and extensively

65 ted to cause a R47H substitution) from three genomewide association studies of Alzheimer's disease an

66 Genomewide association studies of autoimmune diseases ha

67 lyzed data on lifetime suicide attempts from genomewide association studies of bipolar I and II disor

68 Although array-based genotyping has allowed genomewide association studies of common SNPs in tens of

69 Candidate gene and genomewide association studies reveal that these obesoge

70 Recently, several genomewide association studies revealed a highly signifi

71 Following the recent novel finding from genomewide association studies that sequence variation o

72 udies, and to set the stage for the numerous genomewide association studies that will emerge by the e

73 meta-analysis between 2 independent European genomewide association studies, each comparing HIV-1 ser

74 er established genetic variants, mainly from genomewide association studies, modify dietary patterns

75 common variants are typically referred to as genomewide association studies, whereas studies of rare

76 ith complex genetic relationships in various genomewide association studies.

77 ay often be caused by rare alleles missed by genomewide association studies.

78 linkage disequilibrium with SNPs surveyed in genomewide association studies.

79 The purpose of this study was to apply genomewide association study (GWAS) analysis to address

80 be fully characterized and to date only one genomewide association study (GWAS) has been published.

81 Workgroup (PGC-SCZ) has recently published a genomewide association study (GWAS) identifying >100 gen

82 lymorphisms (p < 10(-3) ) from the recent TS genomewide association study (GWAS) in 609 independent c

83 hromosomes 6 and 7 were identified through a genomewide association study (GWAS) of debranched starch

84 genes associated with BHR severity, using a genomewide association study (GWAS) on the slope of BHR

85 A genomewide association study (GWAS) was performed for 1,

86 for their association with neuroticism in a genomewide association study (GWAS).

87 DL1 showed the strongest associations in the genomewide association study (P=5.50x10(-37) and P=2.52x

88 We performed a genomewide association study and replicated the most sig

89 enetic basis of complex diseases such as the genomewide association study are powerful, yet a large g

90 MAIN OUTCOME MEASURES: We conducted a genomewide association study assessing weight gain assoc

91 We performed a genomewide association study by first genotyping blood D

92 We performed a genomewide association study in a discovery set of sampl

93 A genomewide association study in Chinese patients with le

94 samples from Sardinia, Italy, we performed a genomewide association study in multiple sclerosis follo

95 We performed a genomewide association study involving 872 participants

96 We carried out a genomewide association study involving children with ast

97 We conducted a genomewide association study of 194 case patients and 20

98 As a first component of a genomewide association study of families from the Autism

99 applied this approach to analyze data from a genomewide association study of multiplex families ascer

100 We carried out a genomewide association study of serum YKL-40 levels in a

101 eatment using the Alda scale and performed a genomewide association study on samples from one subgrou

102 The authors utilized data from a genomewide association study to examine associations bet

103 We performed a case-control genomewide association study to identify common HCM-asso

104 entric approach via entropy statistics for a genomewide association study to identify disease genes.

105 A genomewide association study was performed in a discover

106 We hypothesized that a genomewide association study would reveal novel pharmaco

107 In this genomewide association study, we found that variants at

108 vitiligo susceptibility loci, we conducted a genomewide association study.

109 to clinical AIDS, we performed a multistage genomewide association study.

110 computationally efficient way for gene-based genomewide association study.

111 sult in increased false positive findings in genomewide-association studies.

112 We determined genomewide associations with the presence of aortic-valv

113 tive analyses of gene expression profile and genomewide binding of EglN2 under hypoxic conditions rev

114 nucleotide triplets that correlates with the genomewide binding preferences of PIC measured by Chip-e

115 reen for metastable epialleles by performing genomewide bisulfite sequencing in peripheral blood lymp

116 genesis of secretory proteins, we screened a genomewide collection of yeast mutants for defective int

117 Genomewide comparison of wheat ESTs that mapped to centr

118 Genomewide comparisons were performed with the use of th

119 an acidophilic microbial community enabled a genomewide, comprehensive investigation of variation in

120 gins of relapse by comparing the profiles of genomewide copy number alterations at presentation in 21

121 locations of tumor samples, or by comparing genomewide copy number array profiles.

122 We also performed genomewide copy-number analysis in 35 patients with cort

123 tified 20 potential drug target genes in two genomewide-corrected gene sets: the neuroactive ligand-r

124 In the secondary analysis, after empirical genomewide correction for multiple testing, suggestive l

125 We have used a novel and highly sensitive genomewide cytosine methylation assay to detect and map

126 The integration of genomewide data from multiple platforms delineated three

127 UCEs are also depleted among 10 of 11 recent genomewide data sets of human CNVs, including 3 obtained

128 We also examined how practical problems with genomewide data sets, such as errors in the genetic map,

129 nded tool for determining the correlation of genomewide data with other datasets or known biological

130 The availability of genomewide dense markers brings opportunities and challe

131 ze, Zea mays ssp. parviglumis, have revealed genomewide departures from the standard neutral equilibr

132 The allele frequency spectrum indicated a genomewide deviation from an equilibrium neutral model,

133 In the present study, we analyzed combined genomewide DNA methylation and gene expression data of p

134 role in epigenetic inheritance, we examined genomewide DNA methylation in partial and complete loss-

135 Genomewide DNA methylation profiles were obtained in a s

136 In this study, we carried out genomewide DNA methylation profiling of 140 DLBCL sample

137 Furthermore, we established that the genomewide down-regulation of miRNA expression at 24 hou

138 o liver regeneration, whereas the subsequent genomewide down-regulation of miRNAs was required for ef

139 Inasmuch as the genomewide effects of CcpA in a human pathogen are unkno

140 Genomewide engineering technologies utilizing recombinee

141 y using conditional loss-of-function models, genomewide expression analyses, chromatin immunoprecipit

142 etical genomics--that is, the combination of genomewide expression data and molecular marker data to

143 emergence of massively parallel sequencing, genomewide expression data production has reached an unp

144 In addition, genomewide expression for a subset of 20 tumors was anal

145 We then investigated the genomewide expression patterns of differentially express

146 Genomewide expression profiling coupled with ChIP-chip a

147 ma has been the lack of a means to carry out genomewide expression profiling of fixed, as opposed to

148 We have demonstrated the feasibility of genomewide expression profiling of formalin-fixed, paraf

149 We show that the genomewide-expression-maps generated using images from e

150 ss regions such as the MHC region as well as genomewide for transplant outcomes that span all solid o

151 Microarray was used for genomewide gene expression analysis on bone marrow-deriv

152 Genomewide gene expression analysis revealed that KSHV v

153 cripts expression in UCB were available from genomewide gene expression profiling.

154 We evaluated genomewide genetic and phenotypic evolution in Candida a

155 ely neutral AFLP loci was close to zero, and genomewide genetic structure was associated neither with

156 As the genomewide genic SNPs become available, our entropy-base

157 European ancestry, all of whom have existing genomewide genotype data sets.

158 scanning; rs6971 genotype was imputed after genomewide genotyping.

159 n planus, and healthy controls (HCs)-using a genomewide high-throughput miRNA microarray.

160 Genomewide homozygosity mapping was used to identify a c

161 Through genomewide homozygosity mapping, we localized the diseas

162 In the present studies we screened a genomewide human phosphatase siRNA library in human embr

163 The genomewide identification of target genes revealed that

164 casei as a model microorganism to proceed to genomewide identification of the functions required for

165 i.e., fecundity variance polymorphism has a genomewide impact on genealogies.

166 ntify undermethylated adenines and cytosines genomewide in a bacterium using second-generation sequen

167 lele-specific expression levels were assayed genomewide in female adult heads of Drosophila melanogas

168 strategies--temporal transcriptome analysis, genomewide in silico FB prediction, and Fur titration as

169 t time, we report a phylogenetic analysis of genomewide insertion/deletion (indel) data, an approach

170 ntinuous traits, offers a convenient way for genomewide interacting QTL analysis of ordinal traits.

171 pairs that are typically analyzed to deduce genomewide interactions between arbitrary loci.

172 We summarize the data by the genomewide joint distribution of these two statistics-te

173 unity for genetic association studies at the genomewide level for elucidating disease etiology.

174 linkage group 21 and was significant at the genomewide level in both the sire and the dam-based anal

175 tivities to specific genes and in regulating genomewide levels of modifications.

176 Genomewide linkage analysis and DNA sequencing were used

177 Causative gene mutation was determined by genomewide linkage analysis and DNA sequencing.

178 We performed genomewide linkage analysis and whole-exome sequencing i

179 Genomewide linkage analysis generated one significant LO

180 Parametric genomewide linkage analysis was performed on 10 affected

181 Genomewide linkage analysis was then performed in all fa

182 ic examination of an excised corneal button, genomewide linkage analysis, fine mapping linkage and ha

183 A genomewide linkage scan in keratoconus families identifi

184 Using a genomewide linkage scan, we detected linkage between idi

185 Genomewide linkage scans were performed in Caucasian (CA

186 Candidate gene studies and genomewide linkage studies have identified genes in the

187 r efforts via candidate gene association and genomewide linkage studies, and to set the stage for the

188 n assays as well as transcript profiling and genomewide localization studies, in combination with a f

189 By genomewide location analysis, we determined that Sall4a

190 induced rhesus asthma model by analyzing the genomewide lung gene expression profile of the rhesus mo

191 In this study, we generated a genomewide map of Ldb1 complex binding sites that reveal

192 positions of these mutations, we developed a genomewide map of single nucleotide polymorphisms (SNPs)

193 In genomewide mapping of expression quantitative trait loci

194 However, there is a lack of a comprehensive genomewide mapping strategy for correlated traits in the

195 An integrated analysis of genomewide messenger RNA (mRNA) expression profiling and

196 Three genomewide metastudies have recently reported associatio

197 We used a genomewide method for detecting regions of CpG methylati

198 Cost-effective genomewide methods for identifying copy number variation

199 We analyzed genomewide methylation in MCL patients with the HELP (Hp

200 es, mouse and Xenopus, coupled with unbiased genomewide microarray profiling.

201 We carried out genomewide microRNA (miRNA) microarray studies during li

202 address these restrictions, we investigated genomewide miRNA expression and copy number data in 86 D

203 In the present study, through a large-scale, genomewide miRNA expression assay, we show that microRNA

204 Genomewide, model-free, multipoint linkage analyses were

205 The combined genomewide mRNA expression profiling/DNA-methylation pro

206 n this article, we developed two methods for genomewide multiple loci mapping: the Bayesian adaptive

207 Genomewide multiple-loci mapping can be viewed as a chal

208 A recent genomewide mutational analysis of glioblastomas (World H

209 Genomewide or linkage-directed association analyses did

210 garithm of the odds ratio [LOD] score, 3.37; genomewide P = .013, 8 (LOD score, 3.03; genomewide P =

211 garithm of the odds ratio [LOD] score, 3.35; genomewide P = .0138) and the other located on chromosom

212 r located on chromosome 18 (LOD score, 3.29; genomewide P = .0159).

213 nomewide P = .031), and 11 (LOD score, 3.19; genomewide P = .020).

214 37; genomewide P = .013, 8 (LOD score, 3.03; genomewide P = .031), and 11 (LOD score, 3.19; genomewid

215 1 approached significance (LOD score, 2.72; genomewide P = .067).

216 ith congeners, yet little is known about the genomewide pattern of introgression among species.

217 e observation of strong sexual dimorphism in genomewide patterns of gene expression in the few specie

218 on in recombination rate will also inform on genomewide patterns of linkage disequilibrium (LD), and

219 ation and development and may play a role in genomewide phenomena such as aging and cancer.

220 e use ChIP, validated by p63-Chip sequencing genomewide profiling analysis, and luciferase assays to

221 The use of direct-to-consumer genomewide profiling to assess disease risk is controver

222 te of use of screening tests associated with genomewide profiling, most of which are not considered a

223 ts are accompanied by sustained decreases in genomewide promoter DNA methylation, gene reexpression,

224 Through a genomewide PtdIns(3)P effector screen in the nematode Ca

225 c variation includes loci of major effect, a genomewide quantitative trait loci (QTL) scan was perfor

226 d aggregates of the yeast prion [PSI+] cause genomewide readthrough translation that sometimes increa

227 t that the dynamics of population growth and genomewide rearrangement contribute to the maintenance o

228 vantage of citrate, we developed a recursive genomewide recombination and sequencing method (REGRES)

229 However, a genomewide regulatory network of leaf development is not

230 By monitoring genomewide replication dynamics of cells exposed to hydr

231 We then performed a genomewide RNA interference screen for regulators of mut

232 Here we report on a genomewide RNAi screen in C. elegans, which identified 1

233 s fighting L. monocytogenes infection, using genomewide RNAi screens in vitro.

234 analysed its transcriptome to understand the genomewide role of GPA1 and compared it with that of our

235 Gene expression analysis and genomewide Runx1 occupancy studies support the hypothesi

236 the nucleotide substitution rate matrix on a genomewide scale across the tree of life.

237 ted the effect of Clp1 on transcription on a genomewide scale using the Global Run-On-Seq (GRO-Seq) a

238 students to the engineering of biology on a genomewide scale while focusing on a limited region of t

239 architecture of the viral transcriptome on a genomewide scale.

240 es between case and control populations on a genomewide scale.

241 nel provides both power and resolution for a genomewide scan.

242 We identified a minimum of five QTL in a genomewide scan: two on chromosome 2 and three on chromo

243 t natural selection in M and S, we performed genomewide scanning in paired population samples from Ma

244 idates is required to verify the accuracy of genomewide scans and clarify the importance of adaptive

245 ncordant regions in another species; and how genomewide scans associating haplotype groups with their

246 etical genomics approaches in the context of genomewide scans for complex trait loci.

247 tion can improve the fidelity of the test in genomewide scans for selection on noncoding DNA.

248 us confirms the signal of selection found by genomewide scans.

249 We performed a genomewide screen for factors that negatively regulate S

250 A genomewide screen for gene deletions that are lethal in

251 Second, we conduct a genomewide screen for genomic regions at which PBL DNA m

252 ntify a BLJ signaling pathway we completed a genomewide screen for mutants that enhance dlg tumorigen

253 We performed genomewide screening for methylated CpG islands and iden

254 A genomewide screening of type II cells identified eosinop

255 fine the genetic basis of AA, we performed a genomewide search for linkage in 20 families with AA con

256 We conducted a genomewide search for structural variants in two cohorts

257 Definitive proof will necessitate genomewide sequence analysis.

258 re cohorts, with one locus (17q21) achieving genomewide significance after meta-analysis.

259 near the proinflammatory gene IL1F9 achieved genomewide significance for mitral annular calcification

260 total of 341 protein-coding genes, attaining genomewide significance for susceptibility to schizophre

261 oprotein(a) (LPA) locus (rs10455872) reached genomewide significance for the presence of aortic-valve

262 replication sets; these variants also showed genomewide significance in a joint analysis.

263 n ancestry, we observed an association, with genomewide significance, between asthma and SNPs at the

264 Three QTLs exhibited genomewide significance, including QTLs on chromosomes 1

265 analyses revealed two associations exceeding genomewide significance.

266 2 showed association with preterm birth with genomewide significance.

267 0x10(-7)), but the association did not reach genomewide significance.

268 ection, and the global meta-analysis reached genomewide significance: P(combined) = 7.76 x 10(-8).

269 We found a genomewide significant association of podoconiosis with

270 This study provides the first genomewide significant evidence implicating variants nea

271 Although genomewide significant evidence of cross-disorder effect

272 In the discovery cohort, one genomewide significant hit located in phosphodiesterase

273 g by Social Responsiveness Scale respondent, genomewide significant linkage for social responsiveness

274 Two genomewide significant QTL and one suggestive QTL were d

275 GWAS adjusted for this mutation revealed genomewide significant signals along 11 Mb around it.

276 od method to fit demographic models to human genomewide single-nucleotide polymorphism (SNP) data.

277 urified T cells, global transcription, and a genomewide single-nucleotide polymorphism (SNP) profile

278 e-brain diffusion tractography together with genomewide, single-nucleotide polymorphism (SNP)-based g

279 To validate the system we performed a genomewide siRNA screen that successfully identified kno

280 In P. daedalea host samples, genomewide SNP variation clustered into two discrete gro

281 Using genomewide somatic neoepitope analysis and patient-speci

282 However, most genomewide studies have focused on model systems, with v

283 ircumvented for some phenotypes by combining genomewide studies in model organisms with subsequent ca

284 in genomic technology, however, have led to genomewide studies of African samples.

285 p to late blastula stage, as identified in a genomewide survey.

286 A number of recent genomewide surveys have found numerous QTL for gene expr

287 ve side, investigations of FOXP2, along with genomewide surveys of gene-expression changes and select

288 We used ChIP sequencing to define genomewide TEAD4 target genes and asked how transcriptio

289 ompleted follow-up after undergoing consumer genomewide testing, such testing did not result in any m

290 We further show genomewide that reciprocal exchange of 5-hydroxymethylcy

291 Here we have employed a genomewide tiling array to examine the lytic transcripto

292 In a prior genomewide transcriptional analysis, we found that IPF M

293 Genomewide transcriptional profiling revealed that multi

294 We determined the genomewide transcriptional program that is rapidly provo

295 We characterized the genomewide transcriptional response to stress also in mi

296 A genomewide transcriptome analysis revealed that most lig

297 fore examined the association between common genomewide variation and lifetime suicide attempts.

298 enotypic variation in ethanol responses with genomewide variation in gene expression and identified m

299 tors that distinguish T and B cells, a truly genomewide view of the transcriptional differences betwe

300 Our analysis provides a genomewide view of the transcriptional outputs of mTOR s