ライフサイエンスコーパス: genomic island

1 sferred from other bacteria and represents a genomic island.

2 e clusters, seven phage regions and a mobile genomic island.

3 ally at the recombination sites flanking the genomic island.

4 enes may also define a previously unreported genomic island.

5 long with bclA) may be part of an exosporium genomic island.

6 dvantage for strains that have acquired this genomic island.

7 o modulating gene expression within the T3SS genomic island.

8 M-19226, carry a copy of trh within the T3SS genomic island.

9 nse systems and mobile genes and elements in genomic islands.

10 ransferred in trans, as are some mobilizable genomic islands.

11 in silico and experimental discovery of new genomic islands.

12 l family of T4SSs involved in propagation of genomic islands.

13 ied as a T4SS involved in the propagation of genomic islands.

14 located on presumptive horizontally acquired genomic islands.

15 16S ribosomal RNA sequences occurs mostly in genomic islands.

16 Its genome contains 6 prophages and 5 genomic islands.

17 for the capture and conjugative transfer of genomic islands.

18 spp. have relied on chromosomally integrated genomic islands.

19 ke domains, some of them encoded in putative genomic islands.

20 s adapted to the spread and rearrangement of genomic islands.

21 ial chromosomes accumulates in blocks termed genomic islands.

22 thways that also facilitate the formation of genomic islands.

23 ters are contained within self-transmissible genomic islands.

24 everal other E. coli strains, identifying 43 genomic islands.

25 an integron structure, designated Salmonella genomic island 1 (SGI1), while we recently demonstrated

26 integrated prophage elements and Salmonella genomic island 1 encoding antibiotic resistance genes.

27 chromosome called PAGI-1 (for "P. aeruginosa genomic island 1").

28 sed on prophage-like elements and Salmonella genomic island 1, provide a simple method for identifyin

29 isolate from Australia was PCR positive for genomic island 11 or a putative transposase sequence, wh

30 One 99-kb island, designated P. aeruginosa genomic island 5 (PAGI-5), was a hybrid of the known P.

31 ColM was detected within the exoU-containing genomic island A carried by certain pathogenic Pseudomon

32 ferent biosynthetic architectures, including genomic islands, a plasmid, and the use of spatially sep

33 traits are unique and distributed over five genomic islands, a prophage, and two plasmids.

34 pumilus maritimus SCM1' revealed a number of genomic islands absent in the Gulf of Maine population.

35 satory mutations in noncore genes located in genomic islands, although genetic reversions were also o

36 ribution of 81 genes belonging to 12 APEC O1 genomic islands among 828 human and avian ExPEC and comm

37 ter degree of similarity in gene content and genomic islands among strains within clades than between

38 s characteristics of a horizontally acquired genomic island and encodes homologues of type IV secreti

39 art and end of a region such as an operon or genomic island and expanded these ranges to add another

40 ns exhibited limited conservation of APEC O1 genomic islands and a distinct repertoire of virulence-a

41 a simple approach to identify phage-derived genomic islands and apply it to show that pathogens from

42 Acquired pathways are incorporated into genomic islands and are commonly exchanged within and be

43 nt, indicating a possible link between these genomic islands and c-di-AMP signalling.

44 account for the conjugative transfer of the genomic islands and may even encode autonomous replicati

45 cholerae infection but did contain putative genomic islands and other accessory virulence factors.

46 However, we observed subtle differences in genomic islands and prophages between the species.

47 In addition, we explore the diversity of genomic islands and their insertion sites among Gram-neg

48 DGR is found within a horizontally acquired genomic island, and it can theoretically generate 10(26)

49 he distribution of putative virulence genes, genomic islands, and insertion sequences across a collec

50 cleotide polymorphisms (SNPs), lacking three genomic islands, and probably having one or more tandem

51 Here, we discuss how a group of related genomic islands are evolutionarily ancient elements unre

52 hanisms that mediate the lateral transfer of genomic islands are for the most part unknown.

53 Genomic islands are mobile DNAs that are major agents of

54 Genomic islands are non-self-mobilizing integrative and

55 Genomic islands are responsible for unique aspects of ba

56 PCR-based analysis indicated that the large genomic islands are widely variable across a large colle

57 hococcus genome, all located within the same genomic island as fciA and fciB These findings, along wi

58 le proteins appeared to correspond to silent genomic islands, as inferred through functional profilin

59 ed ExoU island A, revealed many plasmid- and genomic island-associated genes, most of which have been

60 Tn7-like transposons form genomic islands at a programmed insertion site in bacter

61 These elements form functionally diverse genomic islands at the specific site of Tn7 insertion ad

62 the mechanism underlying mobilization of the genomic islands between strains are unexplained.

63 However, genomic islands can also arise through evolutionary proc

64 While the recognition of genomic islands can be a powerful mechanism for identify

65 An approximately 50-kb genomic island carries genes encoding the T3SS structura

66 -encoding gene was interrogated and an 80-kb genomic island carrying exoU was identified.

67 These genomic islands comprise 672 kb of the 5,231-kb (12.8%)

68 in, and our findings challenge the view that genomic islands consist only of independently evolving m

69 A genomic island consisting of 14 open reading frames, orf

70 ed in identification of a conserved syntenic genomic island consisting of up to 33 core genes in 16 b

71 We find that two of the most pronounced genomic islands contain the ALX1 and HMGA2 loci, which a

72 supplementary tables and within ranges like genomic islands contain the majority of locus tags.

73 system were identified on a low-G+C-content genomic island containing 24 intact genes that appear to

74 , we describe the widespread occurrence of a genomic island containing nitrite and nitrate assimilati

75 these strains also possessed several unique genomic islands containing hypothetical genes with simil

76 phylococcal chromosome cassette mec (SCCmec) genomic island, containing the gene encoding resistance

77 at, in addition to encoding virulence genes, genomic islands contribute to the overall fitness of UPE

78 couples the actions of previously disparate genomic islands, defines VSP-1 as a pathogenicity island

79 a high genome conservation even within their genomic islands, despite their remote geographical local

80 virulence factors, although phage-associated genomic islands dominated the accessory genomes of these

81 Here, we show that a widely distributed genomic island encoding tandem master regulators named F

82 nsferase ubiquitous among the diverse set of genomic islands encoding the serine-rich PsrP glycoprote

83 Overall, the genomic islands examined provide targets for further dis

84 The clustered phage remnants formed genomic islands exhibiting distinct DNA physical signatu

85 This work presents the first example of genomic island formation by a DDE type transposon.

86 similar in gene content and organization to genomic islands found in group B streptococci (GBS), the

87 tion sequences were used as tags to identify genomic islands found in PSE9 but absent in PAO1.

88 ion of genes c3405 to c3410 from PAI-metV, a genomic island from Escherichia coli CFT073, results in

89 Here, we describe novel genomic islands from Photorhabdus that are involved in s

90 Genomic islands gained in the S flexneri 2a lineage over

91 acteria may accumulate blocks of DNA such as genomic islands (GEIs) that encode fitness or virulence

92 Clade I representative induced expression of genomic island genes in cultures and Southern California

93 is mutants having insertions in prophage and genomic island genes.

94 conditions, suggesting that within the T3SS genomic island, genes encoding proteins unrelated to the

95 Moreover, twelve genomic islands (GI) were identified in LAC-4 genome.

96 Virulence genes on mobile DNAs such as genomic islands (GIs) and plasmids promote bacterial pat

97 ose of this study was to examine the role of genomic islands (GIs) as sources of genomic diversity in

98 The acquisition of genomic islands (GIs) by horizontal gene transfer (HGT)

99 Mobile genetic elements such as genomic islands (GIs) have been pivotal in the evolution

100 Among the prokaryotic genomic islands (GIs) involved in horizontal gene transf

101 Brucella genomic islands (GIs) share similarities in their genomi

102 We found that genomic islands (GIs) vary greatly among B. pseudomallei

103 bacterial genomes are relevant for detecting genomic islands (GIs), including pathogenicity islands (

104 enes, which are known insertion hotspots for genomic islands (GIs).

105 prediction and interactive visualization of genomic islands (GIs, regions of probable horizontal ori

106 Seven previously unrecognized genomic islands (>30 kb) were delineated by CGH in addit

107 A 70-kb genomic island (HHGI1) in Helicobacter hepaticus strain

108 A gene cluster of the Haemophilus influenzae genomic island ICEHin1056 has been identified as a T4SS

109 iderable genomic diversity with >300 unique "genomic islands" identified, with the majority of these

110 city is supported by the identification of a genomic island in one of the sequenced CF isolates, enco

111 The metV genomic island in the chromosome of uropathogenic Escher

112 on pathogenic Neisseria species harboring a genomic island in their dif sites.

113 Genomic analysis identified eight genomic islands in chromosome 1 of V. anguillarum 775(pJ

114 genomics data indicate that these loci, and genomic islands in general, have exceptionally low recom

115 H-NST proteins are found in large genomic islands in pathogenic E. coli strains, which are

116 Genomic islands in this free-living photoautotroph share

117 These related genomic islands include the following well-characterized

118 sequences, 10 prophage-like regions, and 17 genomic islands, including the locus for enterocyte effa

119 tain a significant number of large and small genomic islands, including those carrying virulence dete

120 hat, in Enterobacteriaceae, the cluster is a genomic island integrated at the leuX locus, and the phy

121 Various genomic islands intersperse on the genome with transposo

122 This genomic island is absent from the close relative of N. m

123 ndicate that transfer initiation of the tfs4 genomic island is analogous to mechanisms underlying mob

124 omes resistant to methicillin by acquiring a genomic island, known as staphylococcal chromosome casse

125 Many bacterial chromosomes contain genomic islands, large DNA segments that became incorpor

126 en compared with Pst DC3000, including large genomic islands likely to contribute to virulence and ho

127 arger data set consisting of maize assembled genomic islands (MAGIs) that had been aligned to ESTs.

128 e of an improved assembly of maize assembled genomic islands (MAGIs).

129 as chromosomal loci and mediate plasmid and genomic island maintenance through post-segregational ki

130 Genomic islands may contain functional variants involved

131 These 'mobilizable genomic islands' (MGIs) require many ICE-encoded factors

132 in multiple strains of the same species, and genomic islands missing in a given species are often res

133 Three genomic island mutants (Delta PAI-aspV, Delta PAI-metV,

134 se accessory genes were often organized into genomic islands (n = 387) with base composition biases,

135 staphylococcal cassette chromosome (SCC) and genomic island nuSaalpha.

136 The genomic islands nuSaalpha and nuSabeta are found in almo

137 arding the diversification and spread of the genomic island nuSabeta, highlighting the central role o

138 Here, we demonstrated that the genomic island, nuSabeta, encoding an array of virulence

139 cal and phylogenetic associations of the pks genomic island of extraintestinal pathogenic Escherichia

140 Recently, we identified a genomic island of Proteus mirabilis, a common agent of c

141 e syringomycin (syr) and syringopeptin (syp) genomic island of Pseudomonas syringae pv. syringae.

142 in an O55:H7-like progenitor, with 27 of 33 genomic islands of >5 kb and specific for O157:H7 (O isl

143 Here, the genomic islands of APEC O1 were compared to those of oth

144 tion and (2) that even extreme prominence of genomic islands of divergence can be an unreliable indic

145 ocated within one of two exceptionally large genomic islands of divergence separating the Anopheles g

146 ent of local adaptation and the evolution of genomic islands of divergence.

147 ptation sometimes cluster together, forming "genomic islands of divergence." Divergence hitchhiking t

148 Interestingly, similar numbers of genomic islands of elevated dXY are observed in sympatri

149 and the presence of three laterally acquired genomic islands of likely ecophysiological value.

150 On the contrary, genomic islands of S. gordonii strains contain additiona

151 ainder of the genome, resulting in isolated "genomic islands of speciation." We conducted an experime

152 46 fish, we identified 98 clearly demarcated genomic "islands" of high differentiation and demonstrat

153 of chromosomal DNA from cyptic oriTs within genomic islands or elsewhere on the chromosome could be

154 ed to date originated from temperate phages, genomic islands, or prophages (4-8) , and shared propert

155 he presence of certain horizontally acquired genomic islands, or the expression of other virulence tr

156 ILE(FH5)) and the NR-II virulence region of genomic island PAGI-5 (ILE(FH4)).

157 Acquisition of genomic islands plays a central part in bacterial evolut

158 aseolicola where isolates that have lost the genomic island PPHGI-1 carrying the effector gene avrPph

159 Several genes within O-islands (genomic islands present in EHEC but absent from E. coli

160 s located on mobile genetic elements such as genomic islands, prophages, pathogenicity islands, and t

161 Thus, genomic islands provide abundant material for the experi

162 coli (UPEC) strain CFT073 contains 13 large genomic islands ranging in size from 32 kb to 123 kb.

163 We identified 22 E. coli RS218-derived genomic islands (RDIs), using a comparative genome analy

164 tion results in homogenization of the entire genomic island region (~1.5% of the genome) between spec

165 A subset of genomic island regions, including these loci, appears to

166 Analysis of these genomic islands revealed an integrase-associated island

167 to a previously described in vivo-expressed genomic island (Rv0960-Rv1001).

168 tics in staphylococci, mecA, is carried on a genomic island, SCCmec (for staphylococcal cassette chro

169 These diverse genomic islands shared a common evolutionary origin, ins

170 ene transfer within the symbiotic plasmid or genomic island shown here suggests that such diterpenoid

171 A genomic island similar to an island originally identifie

172 The absence of strain- and group-specific genomic islands, some of which appear to be prophages an

173 cA, is carried on a large (20 kb to > 60 kb) genomic island, staphylococcal cassette chromosome mec (

174 Notably, the expression of several genomic islands, such as GTF-B/C, TnSmu, CRISPR1-Cas and

175 Genomic islands, such as pathogenicity islands, contribu

176 Notably, the expression of genes in several genomic islands, such as TnSmu1 and TnSmu2, was differen

177 on junctions after targeting all of the four genomic islands, suggesting a common mechanism of deleti

178 The host-specific requirements of these genomic islands support a model in which the acquisition

179 et al. describe a new type of transmissible genomic island that can be mobilized by co-resident inte

180 ated from human were found to be missing the genomic island that carries genes encoding cytolethal di

181 Aeromonas caviae Sch3N possesses a small genomic island that is involved in both flagellin glycos

182 lar architecture consisting of several large genomic islands that are dispensable for growth in bacte

183 In each pair, we identify genomic islands that are, on average, elevated in both r

184 icity islands (PAIs) are a specific group of genomic islands that contribute to genomic variability a

185 Several genes or genomic islands that have not been reported previously (

186 We analyzed repeat sequences to identify genomic islands that, together with other approaches, su

187 Here we identify a genomic island (the prp gene cluster) in N. meningitidis

188 s to the corresponding PAO1 tRNA(Lys)-linked genomic island, the pathogenicity islands of strain PA14

189 binations of infrequently transferred stable genomic islands: those moving primarily through transfor

190 of novel genetic material, such as the exoU genomic island, through horizontal gene transfer may enh

191 between these populations and found two such genomic "islands." Through growth-rate assays, we found

192 s a large gene cluster, which is a part of a genomic island, TnSmu2.

193 (ORFs) within the approximately 49.7-kb T3SS genomic island to identify potential effector proteins.

194 Comparison of the sequenced ExoU-encoding genomic islands to the corresponding PAO1 tRNA(Lys)-link

195 -dependent receptors, and is part of a 24 kb genomic island unique to the A. macleodii 'surface clade

196 The examination of genomic islands unique to our strain revealed the presen

197 Content of the genomic islands varies, with one containing a prophage a

198 lution of a novel exchangeable meningococcal genomic island was defined for the important human patho

199 In this study, the 132-kb syr-syp genomic island was found to be organized into five polyc

200 A genomic island was identified in the Haemophilus influen

201 Targeting lacZ within the largest 102-kbp genomic island was lethal to wild-type cells and resulte

202 Eleven of these genomic islands were individually deleted from the genom

203 of the locus of enterocyte effacement (LEE) genomic island, which encodes a type III secretion syste

204 The pks genomic island, which is harbored by extraintestinal pat

205 buted throughout the chromosome except in 14 genomic islands, which generally had lower GC content th

206 bute biological function to several putative genomic islands, which may then be further characterized

207 d gene clusters are concentrated in specific genomic islands, which represent hot spots for BGC acqui

208 Significant synteny is seen in the entire genomic island with genomic regions from Salmonella ente

209 port of a diverse family of related syntenic genomic islands with a deep evolutionary origin, and our

210 iquitous mobile genetic elements present as "genomic islands" within bacterial chromosomes.

211 ted MGEs, in silico prediction revealed four genomic islands without essential genes in lengths from