ライフサイエンスコーパス: genomic region

1 e insertions of the transposon into the same genomic region.

2 and heatmaps which characterize the selected genomic region.

3 ilibrium (LD) with each other within a small genomic region.

4 populations were not significant for either genomic region.

5 marks that simultaneously decorate the same genomic region.

6 y and stability of RNA-seq coverage across a genomic region.

7 more powerful for identifying MDD-associated genomic regions.

8 enerally by variants in known T1D-associated genomic regions.

9 a single strain with thirteen characteristic genomic regions.

10 sult of the uniparental inheritance of these genomic regions.

11 ei for accurate identification of accessible genomic regions.

12 lated to phenotypes lie mostly in non-coding genomic regions.

13 have deleterious effects at high-copy-number genomic regions.

14 nd quickly summarize and plot annotations of genomic regions.

15 ne expression, and visualization of specific genomic regions.

16 uch as multi-modal peaks extended over large genomic regions.

17 e found datasets and navigate the identified genomic regions.

18 ted L1s resulted in the deletion of proximal genomic regions.

19 hown that methylation is regulated in longer genomic regions.

20 ive imaging system for targeted detection of genomic regions.

21 OCT4 binds a large set of low-accessible genomic regions.

22 sm and divergence are controlled by the same genomic regions.

23 atial correlations in DNA methylation across genomic regions.

24 n sequencing data often results in a list of genomic regions.

25 linkage clustering of methylation sites into genomic regions.

26 nd CapSTARR-seq techniques in targeted human genomic regions.

27 ies associated with transcriptionally active genomic regions.

28 ts by similarity plots and (v) annotation of genomic regions.

29 hat can be used to edit coding and noncoding genomic regions.

30 accurately the number of copies in specific genomic regions.

31 reported 17 independent signals for AF at 14 genomic regions.

32 lation levels at 17 genomic positions and 12 genomic regions.

33 ith destabilized GFP, we identified an 11-kb genomic region 3' of the Nkx3.1 transcription start site

34 rve head; here we present evidence that some genomic regions affect both IOP and the disc parameters.

35 We evaluated genomic regions altered in their methylation level due t

36 ly associating domain (TAD) over the Shh/ZRS genomic region and enriched interactions between Shh and

37 method that collapses rare variants within a genomic region and models the proportion of minor allele

38 -SunTag-DNMT3A is able to methylate a 4.5-kb genomic region and repress HOXA5 gene expression.

39 sis led to the identification of informative genomic regions and also showed that defined non-coding

40 nds (CGIs) are primarily promoter-associated genomic regions and are mostly unmethylated within highl

41 Genomic regions and candidate genes identified in the pr

42 provides the best representation for complex genomic regions and coding sequences.

43 and domestic environments involve different genomic regions and feral chickens show some evidence of

44 his process operates recurrently at discrete genomic regions and generates driver mutations.

45 Identified genomic regions and genes carrying polymorphisms linked

46 Finally, we identified "plastic" genomic regions and genes that are promising regions to

47 RHM confirmed the effect of these genomic regions and identified new regions on BTA 18 for

48 nd specifically loaded into late replicating genomic regions and is then redistributed during the cou

49 sistance-like genes, originated from various genomic regions and likely moved to their present locati

50 Additionally, DNA methylation in different genomic regions and of different transcript types (i.e.,

51 ting chromatin-modifying enzymes to specific genomic regions and regulating their activities.

52 Identifying the genomic regions and regulatory factors that control the

53 We identified forest:savanna-discriminatory genomic regions and report a set of ancestry informative

54 associations between methylation in specific genomic regions and somatic mutation patterns.

55 repetitive sequences as well as in barcoding genomic regions and structural variants not amenable to

56 ees based on genomic sequences of functional genomic regions and tissue-specific RNA expression in ei

57 veral new cloche candidate genes within this genomic region, and systematically genome-edited each ca

58 , claiming these are restricted to localized genomic regions, and instead emphasized that widespread

59 polymorphism (SNP)-based associations in 20 genomic regions, and significant gene-based findings in

60 nce of sequence variation in this ubiquitous genomic region are severely lacking.

61 ed repair, which suggests that L1-associated genomic regions are hotspots for somatic copy number var

62 t other similar clusters of genes in GC-rich genomic regions are missing from the current genome asse

63 we also mapped five additional genes to this genomic region (ARF5, SND1, LRRC4, RBM28, and FLNC), bri

64 In this study, after analyzing the genomic regions around alpha-type carboxysome operons, w

65 We construct a weighted network with 250-kb genomic regions as nodes and Hi-C interactions as edges,

66 Many are clustered to a small genomic region, as seen in other human herpesviruses.

67 mapping in complex and structurally variant genomic regions, as well as facilitate high-throughput a

68 The apospory-specific genomic region (ASGR) was mapped to a region of reduced

69 rovides the first evidence that 22q11.2 is a genomic region associated with gene-dose-dependent brain

70 A levels in 16,596 individuals revealed five genomic regions associated at genome-wide levels of sign

71 tudies (GWAS) have identified 15 independent genomic regions associated with bladder cancer risk.

72 The goal of fine-mapping in genomic regions associated with complex diseases and tra

73 population with future goals of identifying genomic regions associated with drought tolerance.

74 integrative genomic approach, we identify 53 genomic regions associated with insulin resistance pheno

75 ural experiment, we test the hypothesis that genomic regions associated with monoamine neurotransmitt

76 hat infer protein-binding sites by detecting genomic regions associated with more mapped reads (cover

77 nome-wide association studies have uncovered genomic regions associated with renal function metrics a

78 The present study identified genomic regions associated with susceptibility to bTB us

79 or syndromic diabetes and genes lying within genomic regions associated with T2D common risk.

80 In this study we aimed to identify candidate genomic regions associated with the colour balanced poly

81 rlie phenotypic variation, and identify five genomic regions associated with tooth shape; one region

82 s (1000G) reference set, we identified 9 new genomic regions associated with vertical cup-disc ratio

83 d sequence variants, localized to non-coding genomic regions, associated with kidney function.

84 severe pre-treatment pain, representing one genomic region at 1q44 (rs3862188, P = 3.45 x 10(-8); rs

85 ng wild and domesticated accessions revealed genomic regions bearing the signature of selection under

86 ignal indicates that haplotypes within these genomic regions became isolated from each other earlier

87 ces statistical links between phenotypes and genomic regions, but identifying causal variants remains

88 egate transcriptional activity of particular genomic regions, but not individual herpesvirus transcri

89 sue-specific hydroxymethylated positions and genomic regions characterized by inter-individual variat

90 length of chromosomes, and in mitosis, these genomic regions come together linearly to form the base

91 aused by tandem duplications in a non-coding genomic region containing an active enhancer element for

92 We discovered a genomic region containing the HMGA2 gene that varies sys

93 d over 200 putative horizontally transferred genomic regions containing 4733 protein coding genes.

94 -wide association analysis (GWAS) identified genomic regions containing clusters of ABA-associated SN

95 tent, we predict approximately 516,000 human genomic regions containing CRSs.

96 resent in both datasets were detected within genomic regions containing olfactory receptor, ATP-bindi

97 The genomic regions containing the KIR and HLA class I genes

98 number of CRISPR screens targeting noncoding genomic regions continue to emerge.

99 ic studies have identified several genes and genomic regions contributing to the control of host susc

100 The authors discovered 12 genomic regions contributing to those differences and id

101 First, we mapped genomic regions controlling latitudinal and altitudinal

102 ARTP can give the significance to identify a genomic region covering gene DSC3 being associated with

103 tive analysis reveals cell type-specific and genomic region-dependent regulatory patterns and provide

104 nzymes, and transcription factors, reside in genomic regions devoid of methylation at any stage of se

105 g era, DNase I has mainly been used to study genomic regions devoid of nucleosomes.

106 PDI/RhoGDI pairs are embedded into conserved genomic regions displaying common cis-regulatory element

107 l studies, a precise quantification of which genomic regions disproportionately contribute to the gen

108 here exists a core set of approximately 1600 genomic regions distributed among enhancers and super-en

109 Most genomic regions diverge between clusters with similar ch

110 ated loci, but we also observe several novel genomic regions (e.g., HOX genes) as being epigeneticall

111 ntative region identified within the partial genomic region E2/noncoding region 2 (NCR2) will enable

112 Population genomics data revealed that genomic regions encoding bioenergetic processes are unde

113 Interaction between the genomic region encompassing the most strongly associated

114 Genomic regions encompassing these SNPs were found to ha

115 racy of GBLUP may be achieved by identifying genomic regions enriched for causal genetic variants.

116 th clinically extreme phenotypes to identify genomic regions enriched for rare variation contributing

117 Correctly identifying genomic regions enriched with histone modifications and

118 mbiguous studies of sequence preferences and genomic region enrichment showed that CW methylation is

119 erentiation is extremely low: only six small genomic regions exhibit strong differences.

120 193 markers were identified that illuminated genomic regions exhibiting tetrasomic recombination.

121 A total of 11 SNPs from eight genomic regions (FGFR2, 9q31.2, MAP3K, CCND1, ZM1Z1, RAD

122 neering approach allowed us to probe a large genomic region for enhancer activity without assumptions

123 Our results suggest that availability of genomic regions for activation by lineage-specific facto

124 of population genetic techniques to identify genomic regions for domestication.

125 ngle-nucleotide polymorphisms (SNPs) in four genomic regions for three nose-related traits: columella

126 co-localizing the genes to previously mapped genomic regions for two highly heritable traits, chaff c

127 f Hdac3 in cardiac progenitor cells releases genomic regions from the nuclear periphery, leading to p

128 However, the genotypic variation and the genomic regions governing spike ethylene (SET) productio

129 somal copy number variations, spanning large genomic regions (>100 kb).

130 vation, over many generations, of particular genomic regions (haplotypes) due to the development of l

131 Notably, the genomic region harboring EID1 shows signatures of a sele

132 mparative population analysis suggested that genomic regions harboring energy- and reproduction-assoc

133 biased, high-throughput approach to identify genomic regions harboring recurrent DSBs in primary neur

134 rine albumin-to-creatinine ratio [UACR]) and genomic regions harboring variants with highly different

135 Although 58 genomic regions have been associated with CAD thus far,

136 In total sixteen genomic regions have been associated with POAG (includin

137 s are mainly polygenic, such that individual genomic regions have small effects, and suggested chromo

138 To precisely map genomic regions, high-density linkage maps are a prerequ

139 Genomic regions identified here that show evidence of se

140 tions and regions, which are not enriched in genomic regions identified in genetic studies of schizop

141 The genomic regions identified include several novel loci, s

142 Fine-mapping of genomic regions implicated in genome-wide analyses ident

143 s (<5%) distributed across the 5' UTR and P1 genomic region in all three Sabin serotypes, as well as

144 ory elements distributed over a 329 kbp wide genomic region in Xenopus.

145 P-Seq), we identified Meg3 binding to unique genomic regions in and around the c-Met gene.

146 sequence and structural diversity of complex genomic regions in any species.

147 eQTL) analyses showed many associations with genomic regions in chromosome 2 with also the highest ex

148 berrant DNA methylation patterns at specific genomic regions in fragile X syndrome cells, and identif

149 namics of both repetitive and non-repetitive genomic regions in live cells.

150 st description of amplification at selective genomic regions in mammals and present evidence that thi

151 DNA methylation levels and PTSD symptoms at genomic regions in ZFP57, RNF39 and HIST1H2APS2.

152 genic region which contains highly conserved genomic regions, in prostate cells.

153 Repetitive genomic regions include tandem sequence repeats and inte

154 d for maximal loss of DNA methylation at all genomic regions, including gene body and enhancer region

155 ylated CpGs at numerous loci and at distinct genomic regions, including genes relevant for gamma-amin

156 -8), in fixed-effects meta-analysis) from 15 genomic regions, including SNPs in or near genes involve

157 ermined that inactivating m(6)A in one viral genomic region increases viral titer without affecting R

158 We identified two genomic regions introgressed from red siskins into red f

159 Cell wall related genes mapping in genomic regions involved into tomato biomass production

160 The 22q11.2 genomic region is particularly susceptible to chromosoma

161 Communication between distantly spaced genomic regions is one of the key features of gene regul

162 gh-throughput, whether a gene, or a specific genomic region, is important for fitness under a specifi

163 To identify genomic regions jointly influencing schizophrenia and th

164 tween fast- and slow-growing fish pointed to genomic regions likely involved in growth regulation, an

165 Supercontraction involved genomic regions located in the heterochromatic compartme

166 Most disease variants lie within noncoding genomic regions, making their functional interpretation

167 ggested that major loci, consisting of multi-genomic regions, may be involved in dorsal colour variat

168 nscriptional activator to sites across large genomic regions (more than 100 kilobases) surrounding tw

169 romotes the instability of hard-to-replicate genomic regions, namely common fragile sites (CFS).

170 on analyses can be used to annotate extended genomic regions nominated by studies of schizophrenia, a

171 A genomic region of high divergence corresponded to the se

172 follows that the molecular evolution of this genomic region of HIV-1 is highly constrained, since the

173 yption to conceal the sequence query and the genomic region of interest in positional queries.

174 ines the single-variant GDT statistic over a genomic region of interest.

175 We demonstrate that crossovers reside in genomic regions of "open chromatin", which were identifi

176 -like-sgRNA2, were designed in the identical genomic regions of GhMYB25-like A and GhMYB25-like D, wh

177 There are genomic regions of high differentiation between subpopul

178 tory implications of experimentally obtained genomic regions of interest (ROIs).

179 genetic and epigenetic variation to identify genomic regions of interest containing combinations of m

180 ogy for generating dense sgRNA libraries for genomic regions of interest, and a proof-of-principle sc

181 -based probes inefficient for the capture of genomic regions of NHP for sequencing and study.

182 3 (svRNA-nsp3.1 and -nsp3.2) and N (svRNA-N) genomic regions of SARS-CoV.

183 Evidence for additional genomic regions outside of the kelch13 locus associated

184 hat are significantly enriched from the same genomic regions (P < 0.05), revealing a compartmentalize

185 equence reads from 85,542 men to identify 19 genomic regions (P < 5 x 10(-8)) that are associated wit

186 not involve degenerate primers targeting HPV genomic regions, PCR bias in genotype detection is minim

187 ught and heat stress, and revealed important genomic regions possibly involved in the geographic dive

188 Comparative analyses have identified genomic regions potentially involved in human evolution

189 We identify a Mb-scale genomic region present in weedy rice but not cultivated

190 and trans-acting chromatin contacts to other genomic regions previously associated with analogous phe

191 d phenotypic observations with haplotypes of genomic regions previously linked to TMEV susceptibility

192 patients following-up on the most promising genomic regions previously reported.

193 Genomic regions putatively selected during modern temper

194 Heritabilities of the genomic regions ranged between 0.05 and 0.08 across the

195 GeNemo reports any genomic regions, ranging from hundred bases to hundred t

196 We defined schizophrenia risk loci as genomic regions reaching genome-wide significance in the

197 Our analysis defines 96 genomic regions recurrently targeted by homozygous delet

198 l attainment are disproportionately found in genomic regions regulating gene expression in the fetal

199 enotype prediction and the identification of genomic regions relating to AMR, we have updated the PAT

200 homozygous variants were found in two SAMD7 genomic regions relevant for binding of the retinal tran

201 tion of transcripts emerging from repetitive genomic regions remains enigmatic.

202 raphically specific populations, to identify genomic regions representing selection signatures.

203 ct gene regulation by amplifying a subset of genomic regions required for specific cellular function

204 To determine the genomic regions responsible for PM resistance in a set o

205 ion analyses of the 44 genes encoded in this genomic region revealed that only a homolog of Arabidops

206 We identified 2 variants in the same genomic region (rs2270368 and rs17221417) that interact

207 resemble classical insulator elements: short genomic regions sensitive to DNase digestion that are st

208 At least 39 additional genomic regions show signals of introgression as strong

209 further of note that MIR9-2 is located in a genomic region showing strong evidence for association w

210 this study provides a procedure to identify genomic regions showing methylation differences in a mix

211 llenges, from a genome-wide scan to identify genomic regions showing signatures of positive selection

212 The genomic regions showing this pattern are unlikely to con

213 ssibly maintained by balancing selection, at genomic regions significantly enriched for genes associa

214 Positive predictions tend to cluster in genomic regions, so we apply a statistical approach to i

215 x gene family, the DNA sequence of a 1.75-Mb genomic region spanning the Gli-2 locus was analyzed in

216 The genomic regions spanning crossovers were significantly e

217 sociation analyses identified at least eight genomic regions strongly associated with bull fertility.

218 We also inferred putative genomic regions subject to natural selection after this

219 on was replaced with the corresponding human genomic region, such that the human transporter is expre

220 DS domain proteins recognize partly distinct genomic regions, suggesting that DNA binding specificity

221 s of linkage disequilibrium can arise in the genomic region surrounding a selected locus.

222 er analysis revealed an enhancer activity at genomic region surrounding rs4631830 which was expected

223 artificial chromosomes (BAC) to analyze the genomic region surrounding the Eya1 locus for enhancer a

224 , meiotic recombination occurs at 1- to 2-kb genomic regions termed hotspots, whose positions and act

225 This variant lies within a genomic region that includes IL12B and is embedded in an

226 immune response, is an example of a complex genomic region that varies in gene copy number.

227 Somatic mutations within noncoding genomic regions that aberrantly activate oncogenes have

228 Using quantitative genetics, we identify 12 genomic regions that affect parental care, 8 of which ha

229 ataset are enriched in functionally-relevant genomic regions that are active in both human neural cre

230 its ability to manipulate targeted genes and genomic regions that are complementary to a programmed s

231 methylation counts are analyzed to determine genomic regions that are differentially methylated betwe

232 lure to restart replication forks stalled at genomic regions that are difficult to replicate or conta

233 cantly (p = 7.30 x 10(-9)) more prevalent in genomic regions that are likely to have undergone recent

234 breakpoints are preferentially recovered in genomic regions that are observed to be active and thus

235 Defensin genes generally reside in complex genomic regions that are prone to structural variation,

236 To pinpoint genomic regions that are regulated by O-GlcNAc levels, w

237 ential of using sequence data in identifying genomic regions that are responsible for agriculturally

238 ferent non-African populations, characterize genomic regions that are significantly depleted of archa

239 tive genome analysis, we identified multiple genomic regions that are specific for, or absent from, t

240 Common fragile sites (CFSs) are genomic regions that are unstable under conditions of re

241 HOTAIR binding sites were enriched at genomic regions that become hypermethylated with increas

242 n of ChIP-seq technology is the detection of genomic regions that bind to a protein of interest.

243 The study of genomic regions that contain gene copies and structural

244 We identify two genomic regions that contain genes related to immune fun

245 ss 36 quantitative traits, and identified 25 genomic regions that contribute significantly to the gen

246 heritability analysis can be used to detect genomic regions that contribute to disease risk.

247 association studies have mapped thousands of genomic regions that contribute to phenotypic variation,

248 Notably, we find 6 genomic regions that contribute to the genetic correlati

249 We studied genomic regions that could provide better molecular disc

250 associated DNA methylation marks occurred in genomic regions that harbored p53 binding sites and in g

251 regions syntenic with pearl millet or maize genomic regions that have been previously shown to affec

252 Of the 106 signals, 6 are in genomic regions that have not been implicated with relat

253 ermplasm were genotyped and used to identify genomic regions that have undergone positive selection.

254 roaches, ZHp and di values, we identified 22 genomic regions that may have contributed to the phenoty

255 Using 4C-seq, we identify genomic regions that physically interact with the 92 DRE

256 of which are within approximately 300 kb of genomic regions that possess signatures of positive sele

257 tment in both progenitors and neutrophils or genomic regions that switched from the euchromatic to th

258 a scan for selective sweeps, we find several genomic regions that were likely targets of domesticatio

259 llele sharing among three individuals in the genomic regions they examined is "...unlikely to arise i

260 regulation with epigenetic marking of active genomic regions through histone post-translational modif

261 ting the 5' untranslated region (UTR) and P1 genomic region to characterize vaccine-related polioviru

262 nsic cellular factors may predispose certain genomic regions to breakage.

263 A common analysis step is to annotate such genomic regions to genomic annotations (promoters, exons

264 Binding of FACT to these genomic regions triggers a p53 response.

265 gulated rereplication is used to amplify six genomic regions, two of which contain genes encoding egg

266 ormance of genotypes and the contribution of genomic regions under current and future stress situatio

267 We found that genomic regions under differential selection contained c

268 R), and further analyzed the results to find genomic regions under recent selection in multiple pureb

269 Our search for genomic regions under selection reveals signatures of se

270 Finally, genomic regions underlying correlations among allocation

271 ion from H. melpomene into H. besckei in the genomic region upstream of the gene optix, known to cont

272 P1 locus is elevated relative to the average genomic region, we found that interhomolog meiotic recom

273 ples before and after the extreme winter, 14 genomic regions were differentiated in the surviving sou

274 Novel reoccurring altered genomic regions were identified, and the presence of CNA

275 Three independent SNPs from two genomic regions were significantly associated with apoA-

276 as further applied to identify ETEC-specific genomic regions when compared to non-ETEC genomes, as we

277 Together, our study pinpoints three novel genomic regions where longitudinal decreases in DNA meth

278 analysis of ChIP-seq data identified several genomic regions where the cooperativity promoting sequen

279 tially expressed lncRNAs homologous to human genomic regions which contain single-nucleotide polymorp

280 ed that spacers acquired from early-injected genomic regions, which direct Cas9 cleavage of the viral

281 matin of dual-strand piRNA clusters, special genomic regions, which encode piRNA precursors.

282 n and chromatin accessibility of an upstream genomic region with enhancer activity.

283 RGmatch simplifies the association of a genomic region with its closest gene.

284 sociations of the 6 SNPs within FSTL1-coding genomic region with RCC risk and postoperative prognosis

285 The relative location of a genomic region with respect to the gene (gene area) is i

286 Superenhancers (SEs) are large genomic regions with a high density of enhancer marks.

287 Large genomic regions with a paucity of ORC sites are strongly

288 32,662 chromatin determinant regions (CDRs), genomic regions with different epigenetic characteristic

289 nt study analyzes the phylogenetic signal of genomic regions with different inheritance patterns usin

290 eplicates of the same sample yielded minimal genomic regions with DMRfinder, whereas two alternative

291 We also identified 18 genomic regions with expression quantitative trait loci

292 Consistent with local recruitment of DDR, genomic regions with higher H3K36me3 had a lower mutatio

293 pture parental sequences preferentially from genomic regions with low methylation levels and high rec

294 enriched among discordant calls but also in genomic regions with low sequence complexity.

295 Genomic regions with recurrent DNA copy number variation

296 iption factor binding sites were enriched in genomic regions with regeneration-responsive H3.3 occupa

297 hypothesis that nuclear factors that bind to genomic regions with SCS could functionally interact wit

298 icing of its target genes through binding to genomic regions with sequence motifs that are conserved

299 trition-sensitive, differentially methylated genomic regions, with most (87%) specific for generation

300 ts and interpolates expected concordance for genomic regions without data.