ライフサイエンスコーパス: genomic sequence

1 shows protein annotations in the context of genomic sequence.

2 exon order inconsistent with the underlying genomic sequence.

3 , integrated with matched transcriptomes and genomic sequence.

4 tually all clotting factors in the zebrafish genomic sequence.

5 s and predict splicing outcome directly from genomic sequence.

6 ucts encoded trans-frame with respect to the genomic sequence.

7 tudy the problem of RNA motif search in long genomic sequences.

8 ence sequence, rather than with the complete genomic sequences.

9 nscription factor (TF) binding affinities to genomic sequences.

10 e transcripts and proteins on transcript and genomic sequences.

11 oci, we were able to visualize nonrepetitive genomic sequences.

12 er, to distinguish enhancers from background genomic sequences.

13 ach for annotating regulatory adaptations in genomic sequences.

14 anscription or epigenetic factors binding on genomic sequences.

15 eting the approximately 23 kb of intervening genomic sequences.

16 ity-by-descent (IBD) tracts between pairs of genomic sequences.

17 e on the challenging problem of interpreting genomic sequences.

18 s enables the visualization of nonrepetitive genomic sequences.

19 ucleases that generate mutations at targeted genomic sequences.

20 nd generates high-quality LTR libraries from genomic sequences.

21 leading to the reproducible loss of specific genomic sequences.

22 ate functional annotation of uncharacterized genomic sequences.

23 pression despite displaying nearly identical genomic sequences.

24 ons can be useful parameters for analysis of genomic sequences.

25 accurate and consistent characterization of genomic sequences.

26 tions, and assist the assembly of fragmented genomic sequences.

27 struction of RGN reagents to target specific genomic sequences.

28 of mutants by obtaining >500 bp of flanking genomic sequences.

29 the straightforward modification of desired genomic sequences.

30 driver mutations can occur within noncoding genomic sequences.

31 to effectively and efficiently compress the genomic sequences.

32 g of the utility and limitations of pathogen genomic sequencing.

33 nfirmed with the nitrate reductase assay and genomic sequencing.

34 DNA methylation, when analyzed by bisulfite genomic sequencing.

35 ticles evaluated the entire microbiome using genomic sequencing.

36 ion by integrating heterogeneous features of genomic sequences, 16 histone modifications with a multi

37 ral RNA substrate bearing the authentic DENV genomic sequence (5'-(m7)G0pppA1G2U3U4G5U6U7-3'), and S-

38 aVE) is a database of curated papillomavirus genomic sequences, accompanied by web-based sequence ana

39 describe the application of population-based genomic sequencing after chemical mutagenesis to map bac

40 Coalescent-based simulation software for genomic sequences allows the efficient in silico generat

41 ide free energy) that can be calculated from genomic sequences alone has performance that rivals the

42 to study individual human PPI networks (from genomic sequences alone) for personalized medicine.

43 Empirical data from genomic sequencing along with prospects for combining st

44 Vaccine-virus relatedness was assessed by genomic sequence analysis and hemagglutination inhibitio

45 1 to a 1.1-Mb chromosomal region and provide genomic sequence analysis and mechanistic evidence suppo

46 DNA genomic sequence analysis identified novel dominant hete

47 Genetic MLST clustering was confirmed by genomic sequence analysis, indicating that the MLST sche

48 Large genomic sequencing analysis as part of precision medicin

49 As) can induce mutations in 90% of the miRNA genomic sequences analyzed.

50 uctural changes affect on average 4.1 kbp of genomic sequence and 29 coding bases per generation, whi

51 As of September 2013, the database contained genomic sequence and a basic set of annotation 'tracks'

52 As of September 2012, genomic sequence and a basic set of annotation 'tracks'

53 nline public access to a growing database of genomic sequence and annotations for a large collection

54 ole in gene regulation and its dependency on genomic sequence and environment are not fully understoo

55 ved annotations to the latest version of the genomic sequence and its annotations.

56 e challenge of the overwhelming abundance of genomic sequence and other biological data is the use of

57 These SVs rearranged 3.8 Mb of genomic sequence and resulted in 42 putative loss-of-fun

58 s were found to reflect variation in the HCV genomic sequence and the intrahost composition of the HC

59 a transformation function between the static genomic sequence and the primary spatial specification p

60 ir cognate transcription factors (TFs) using genomic sequence and transcriptomic data.

61 splacement amplification and FACS, to obtain genomic sequences and cell size information from unculti

62 t genomic sequencing, we are able to analyze genomic sequences and cell sizes of hundreds of individu

63 accelerated with the genetic revolution, as genomic sequences and genetic tools became available for

64 g advantage of the large number of available genomic sequences and growth temperature data, we presen

65 ed NGS is useful and robust to acquire viral genomic sequences and may provide important ways to defi

66 The new RSV genomic sequences and the novel sequencing method report

67 phylogenetic clustering between Zambian KSHV genomic sequences and those derived from Western countri

68 thms for pairwise and multiple alignments of genomic sequences and whole-genome assemblies, has becom

69 e improvements may permit real-time benchtop genomic sequencing and antimicrobial resistance gene det

70 Genomic sequencing and structural genomics produced a va

71 nology has previously been applied mainly to genomic sequencing and targeted re-sequencing.

72 Using comparative genomics, sequence and structure analysis, we uncovered

73 Here we present six nearly complete HSV-2 genomic sequences, and, with the addition of two previou

74 These include publication of the genomic sequence, antibiotic resistance profiling, selec

75 Accurate full-length genomic sequences are important for viral phylogenetic s

76 Fourth, at least 40 Kbp missing genomic sequences are recovered in the C. elegans genome

77 The first approach uses a PWM and background genomic sequence as input to estimate lambda for a speci

78 s to predict both nucleosome occupancy along genomic sequences as well as binding to known positionin

79 constructs containing complete agt and Taf1 genomic sequences as well as various chimeric constructs

80 isoforms, their presence seems to constrain genomic sequences, as suggested by the significant bias

81 equencing has enabled researchers to perform genomic sequencing at rates that were unimaginable in th

82 virulence, and there are currently only two genomic sequences available.

83 is not reflected in the conservation of the genomic sequences, but is associated with conserved epig

84 corporate metabolic pathways discovered with genomic sequencing, but direct comparisons between model

85 NA endonuclease, can be targeted to specific genomic sequences by engineering a separately encoded gu

86 The Cas9 endonuclease can be targeted to genomic sequences by programming the sequence of an asso

87 n-associated RNAs (caRNAs) with their target genomic sequences by proximity ligation, forming RNA-DNA

88 in sodium channelopathies, the results from genomic sequencing can only be appropriately interpreted

89 r the past 15 years for identifying within a genomic sequence candidate CRMs consisting of clusters o

90 with variations between reads and reference genomic sequences caused both by legitimate differences,

91 However, despite genomic sequence conservation, changes in protein intera

92 This generated ~1.7 Gb of genomic sequence containing an estimated 2/3 of all More

93 echnique to eventually obtain a C. bombicola genomic sequence containing an open-reading-frame putati

94 ervice, researchers are able to retrieve the genomic sequence coordinates for proteins in UniProtKB.

95 otential existence of such complex motifs in genomic sequences could have biological implications and

96 A new study demonstrates that genomic sequencing coverage of plasma DNA fragments arou

97 nentially with the advent of high-throughput genomic sequencing, creating a significant challenge for

98 Using genomic sequence data and polymerase chain reaction-base

99 of obtaining informative transcriptomic and genomic sequence data for both fully sequenced and non-s

100 ersity of BMC shell building blocks found in genomic sequence data for the construction of novel comp

101 precedented scale of data: >390,000 bases of genomic sequence data from each of 198 species of living

102 nce of our approach by visualizing community genomic sequence data from simulated as well as groundwa

103 (14)C dates, and morphological, isotopic and genomic sequence data from two human skulls from the sta

104 Here we analyse genomic sequence data in mammals that have independently

105 Using available genomic sequence data on coagulation factor VIII and pre

106 y demonstrates the use of publicly available genomic sequence data to evaluate a PCR assay for distin

107 Genomic sequence data was contextualised through compari

108 a migration that is clearly reflected in our genomic sequence data, and with a general absence of dis

109 analysis of the growing amounts of community genomic sequence data.

110 logy has led to an explosive accumulation of genomic sequence data.

111 the concept of rational vaccine design from genomic sequence data.

112 40 single-cell transcriptomes, combined with genomic sequence data.

113 eloped to aid the quality control process of genomic sequence data.

114 igh accuracy from paired-end high-throughput genomic sequencing data and pinpoints their breakpoints

115 ng capabilities to identify neoantigens from genomic sequencing data are a limiting factor for unders

116 ents, we analyzed non-human sequences in 150 genomic sequencing data files from the 1000 Genomes Proj

117 The quality of whole-genomic sequencing data is comparable across all samples

118 n an ultra-fast, high-throughput manner from genomic sequencing data.

119 tags of various lengths against cDNA and/or genomic sequence databases.

120 in the RNA Families Database or annotated in genomic sequences databases, and their phylogenetic dist

121 ulates phylogenies inferred from much larger genomic sequence datasets.

122 recently been augmented by population-based genomic sequence datasets.

123 By applying laSV to 97 tumor-normal paired genomic sequencing datasets across six cancer types prod

124 ant benefits that continue to be gained from genomic sequencing, dedicated efforts are needed to avoi

125 sistent cell lineages, all sharing identical genomic sequences despite strongly distinct phenotypes.

126 Functional enhancers can be mapped by genomic sequence disruption, but this approach is limite

127 icing-modulator, albeit less frequently than genomic sequence diversity.

128 representation of racial minorities in large genomic sequencing efforts is unclear, and could have an

129 e absent in plants, C. reinhardtii possesses genomic sequences encoding TRP proteins.

130 Dense methylation is enabled by a regime of genomic sequence evolution that enriches CG dinucleotide

131 Manipulation of genomic sequences facilitates the identification and cha

132 r biobanks are integrating more tightly with genomic sequencing facilities and with those creating an

133 predict methylation in Oryza sativa based on genomic sequence features and gene expression data.

134 The genomic sequence flanking editing sites is highly conser

135 Genomic sequences flanking the 3'-side of L1s were ampli

136 cture and additional signals of selection on genomic sequence for the loci that affect traits.

137 Targeted genomic sequence for WNT4 and WNT5A was determined in 10

138 Having genomic sequences for at least six EPNs opens the possib

139 sequence-specific molecular tool for editing genomic sequences for basic research in life sciences an

140 We therefore generated complete genomic sequences for each GALV strain using hybridizati

141 e novo whole-genome sequence of R. bieti and genomic sequences for the four other species.

142 cleotide signatures extracted from assembled genomic sequence fragments.

143 sequence assemblers then construct the whole genomic sequence from these reads.

144 The PhytoPath resource contains data for 135 genomic sequences from 87 plant pathogen species, and 13

145 We used viral genomic sequences from isolates collected from exhibitio

146 re we report phylogenic analysis using whole genomic sequences from seven genotype 1E and three genot

147 Comparison of genomic sequences from several tetraploid (AtDt) Gossypi

148 In this study, Ppd-A1 genomic sequences from the 5' UTR and promoter region we

149 puting technology makes it possible to build genomic sequences from the billions of reads within a mi

150 ere we test the hypothesis that inclusion of genomic sequences from the rhodopsin gene can improve th

151 However, these samples contain genomic sequences from various sources that complicate t

152 The avalanche of genomic sequences generated in the post-genomic age requ

153 tween blood and saliva samples; (2) Complete Genomics sequences had substantially higher error rates

154 elected group of organisms solely from their genomic sequences has been developed and successfully te

155 Genomic sequencing has driven precision-based oncology t

156 Genomic sequencing has implicated large numbers of genes

157 The throughput of genomic sequencing has increased to the point that is ov

158 Although genomic sequencing has provided a better understating of

159 Further, recent explosion in genomic sequencing has revealed recurrent ACK1 gene ampl

160 Additionally, genomic sequencing has revealed the complexity of the ca

161 Genomic sequencing has substantial epidemiologic value i

162 Ancient genomic sequences have started to reveal the origin and

163 tic mutation genotyping and massive parallel genomic sequencing have become increasingly feasible at

164 The ability to precisely modify any genomic sequence holds the key to realizing the full pot

165 orthologue of the mouse Rosa26 locus through genomic sequence homology analysis.

166 d on comprehensive systems-scale analysis of genomic sequence homology and phylogenetic relationships

167 Restriction enzyme analysis and genomic sequencing identified 2 clusters of closely rela

168 ceptor, and database searches and additional genomic sequencing identified five maize homologs includ

169 clusters of overlapped TUs (TUCs) along the genomic sequence; (ii) the intergenic regions in front o

170 motif instances of a query motif in provided genomic sequences, (iii) motif comparison and clustering

171 that a fast-evolving subset of the noncoding genomic sequence important for chromosome pairing and sy

172 (TAEC), which utilizes the similarity in the genomic sequence in addition to the result of an alignme

173 rs with the ability to manipulate nearly any genomic sequence in human cells and model organisms.

174 ing revealed the presence of identical HPIV3 genomic sequence in the two of the cases with hospital-a

175 e iteratively integrated into the repetitive genomic sequences in a modular manner using robotic auto

176 agents have been successfully used to modify genomic sequences in a wide variety of cells and organis

177 Here we use a library of Xenopus tropicalis genomic sequences in bacterial artificial chromosomes (B

178 ded DNA oligonucleotides to capture specific genomic sequences in cross-linked chromatin fragments an

179 ISPR)-associated endonuclease Cas9 to target genomic sequences in the Caenorhabditis elegans germ lin

180 The source of the microbial genomic sequences in the RefSeq collection is the set of

181 on of five genes was quantified by bisulfite genomic sequencing in d-200 dorsal prostates across BPA

182 erine metabolism and highlights the power of genomic sequencing in revealing the unsuspected allelic

183 y one allele independently of the underlying genomic sequence, in a cell type-specific manner.

184 plant one-box and composite REs in a single genomic sequence, in a pair of aligned homologous sequen

185 Transformation of an 8-kb genomic sequence including CNL13 into the susceptible wh

186 G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natura

187 but no ESTs match this sequence and limited genomic sequences indicates a pseudogene containing fram

188 Recent evidence from genomic sequencing indicates a 15-year interval for gene

189 We exploited the detailed genomic sequencing information of a large number of Arab

190 We present the full genomic sequences, insertion sites and phylogenetic anal

191 era of "next-gen cytogenetics," integrating genomic sequencing into the prenatal diagnostic setting

192 iPSC) generation does not require changes in genomic sequence, iPSCs acquire unlimited growth potenti

193 Since the genomic sequence is invariant during embryogenesis, this

194 Resolving tandemly repeated genomic sequences is a necessary step in improving our u

195 The number of publicly available Borrelia genomic sequences is growing rapidly with the discovery

196 nsequently, the number of available complete genomic sequences is increasing rapidly.

197 sorders, and targeted and massively parallel genomic sequencing is beginning to be used in clinical p

198 The translational utility of genomic sequencing is clear, from understanding of human

199 Large scale genomic sequencing is now widely used to decipher questi

200 rises insertion, deletion and duplication of genomic sequence, is an informative type of genetic vari

201 or online operon prediction on user-provided genomic sequences; (iv) an intuitive genome browser to s

202 rapy-resistant brain tumours, which, despite genomic sequencing, lack effective molecular targets.

203 Predicting the molecular complexity of a genomic sequencing library is a critical but difficult p

204 rapid design of novel SSEs against specific genomic sequences making them potentially suitable for t

205 , we have used the more definitive bisulfite genomic sequencing method to examine CpG methylation in

206 Genomic sequencing might help to establish a diagnosis,

207 We determine draft-level genomic sequence of 50 diverse military isolates and con

208 some (BAC) contig, and obtained a continuous genomic sequence of 871,711 base pairs.

209 In 2012, the complete genomic sequence of a new and potentially harmful influe

210 The knowledge of the genomic sequence of JMRV, and the ability to easily prop

211 Here we report the genomic sequence of M. lignano and an accompanying chara

212 The genomic sequence of Spirodela polyrhiza, the smallest an

213 We present the complete genomic sequence of the essential symbiont Polynucleobac

214 ly associated SNP at this locus), within the genomic sequence of the FAM125B gene.

215 The genomic sequence of the resistant virus, designated clon

216 evailed during the epidemic period, complete genomic sequences of 23 HAdV-D8 isolates were generated

217 rding the evolution of WEEV, we analyzed the genomic sequences of 33 low-passage-number strains with

218 Genomic sequences of Chinese Spring show that the D geno

219 ws the conditional, site-specific removal of genomic sequences of essential and non-essential genes b

220 Despite the efforts to establish complete genomic sequences of eukaryotic organisms, the so-called

221 Here, partial genomic sequences of four novel algal viruses were assem

222 We built phylogenetic trees based on genomic sequences of functional genomic regions and tiss

223 Exhaustive comparison of the genomic sequences of human, macaque, and mouse ADAMTS5 g

224 Due to the large redundancies among genomic sequences of individuals from the same species,

225 However, retargeting meganucleases to genomic sequences of interest remains challenging becaus

226 Genomic sequences of M. tuberculosis isolates displayed

227 curring bacteriophages by analyzing the full genomic sequences of over 100 isolates of Synechococcus-

228 Here, partial and complete genomic sequences of recent virulent isolates of genotyp

229 he applications of our results by clustering genomic sequences of several vertebrate and tree species

230 The availability of genomic sequences of several Verticillium species trigge

231 In this study, we determined nearly complete genomic sequences of six additional HSV-2 isolates, usin

232 ing (NGS) is a powerful technology to define genomic sequences of the viruses.

233 hibitors is important for targeting specific genomic sequences of therapeutic value.

234 Genomic sequencing of CDV isolated from one of the infec

235 Genomic sequencing of Chlamydia indicated this medically

236 Recent intensive genomic sequencing of hematopoietic malignancies has ide

237 We confirmed this hypothesis by genomic sequencing of progeny from young and old plants.

238 Using genomic sequencing of synthetic and natural allopolyploi

239 Full length genomic sequencing of the 2010 H14 isolates demonstrated

240 By genomic sequencing of these T-cell clones, we identified

241 on cellular context, stimulating deletion of genomic sequence or insertion of non-homologous DNA at t

242 ta, but detection typically requires matched genomic sequence or multiple related expression data set

243 conclusion, molecular phylogeny of complete genomic sequences proved a monophyletic HAdV-D8 epidemic

244 s represent the largest number of KSHV whole-genomic sequences published to date and the first time t

245 a substantial portion of transcriptomic and genomic sequence reads, but are typically ignored in mos

246 in gel microdroplets (GMDs) to improve full genomic sequence recovery.

247 ver, their identification and recognition in genomic sequences remains challenging.

248 The novel sequencing method and the new RSV genomic sequences reported here expand our knowledge bas

249 ology is limited by dominance of unannotated genomic sequences representing taxonomic and functional

250 Characterization of full genomic sequences revealed the existence of a single rec

251 An alignment of cDNA and genomic sequences revealed three introns with the first

252 DNA methylation profiling and bisulfite genomic sequencing revealed that KLF4 expression reduced

253 Genomic sequencing revealed that NI1060 is a mouse-speci

254 ific DNA marker (NM4182) located on a single genomic sequence scaffold.

255 We conducted transcriptomic and/or genomic sequence search, subsequent phylogenetic analysi

256 Here we present single-cell genomic sequencing (SiC-seq), which uses droplet microfl

257 ely defend against phages by acquiring short genomic sequences (spacers) that target specific sequenc

258 y-based designs are regaining popularity for genomic sequencing studies because they provide a way to

259 Genomic sequencing studies of breast and other cancers h

260 These parasites have similar biology and genomic sequence, suggesting that all three diseases cou

261 By taking account of the similarity in the genomic sequence TAEC outperforms other available tools

262 er stitching-that increases the diversity of genomic sequences targetable by ZFNs.

263 s derived from chemical structure (drugs) or genomic sequence (targets).

264 ts many advantages, scRNAseq, like any other genomic sequencing technique, is susceptible to the infl

265 Advances in genomic sequencing technologies have improved the abilit

266 one of 11 HPyVs recently discovered through genomic sequencing technologies.

267 Innovations in both tumor genomic sequencing technology and the development of dru

268 With advances in genomic sequencing technology, the number of reported ge

269 f telomere addition is increased at specific genomic sequences termed sites of repair-associated telo

270 spiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, partic

271 We identify genomic sequences that are targeted by islet transcripti

272 gene, we have identified 182 flanking donor genomic sequences that could be used to complete the ass

273 s has revealed a class of non-protein-coding genomic sequences that display an extraordinary degree o

274 Enhancers are also the genomic sequences that encode the incredible diversity o

275 We concentrate on nuclear genomic sequences that have been published in the past f

276 These elements can capture ectopic genomic sequences that lead to the formation of new gene

277 ation procedure for directing integration of genomic sequences that leads to a 5-fold increase in the

278 cs can leverage the vast amount of available genomic sequences to reconstruct and analyze transcripti

279 or leap from merely describing and comparing genomic sequences to surveying them for direct indicator

280 led 32 pseudomolecules (supercontigs) of the genomic sequences to the 20 chromosomes of S. polyrhiza.

281 In this study, we have used targeted genomic sequencing to evaluate the contribution of genet

282 Standard genomic sequencing to identify all heterozygous SNPs in

283 We used genomic sequencing to identify potentially pathogenic ge

284 The use of genomic sequencing to investigate microbes has expanded,

285 We used genomic sequencing to understand the establishment and d

286 estingly, there is a correlation between the genomic sequence type and virulence factor profiles base

287 hallenging to design effective ZFNs for many genomic sequences using publicly available zinc-finger m

288 sing evidence that the phenotypic effects of genomic sequence variants are best understood in terms o

289 be because of differences in common or rare genomic sequence variation, environmental factors or the

290 onrandom variation in the ages of background genomic sequences, we find that mammal-specific enhancer

291 ical and information-theoretic properties of genomic sequences, we need specialized compression algor

292 n-orangutan alignments of neutrally evolving genomic sequences, we segment the human genome into regi

293 rated index-cell sorting and high-throughput genomic sequencing, we are able to analyze genomic seque

294 Changes in genomic sequence, weight, temperature, histopathologic f

295 Genomic sequences were clustered based on the spatiotemp

296 e was beginning to emerge as the first viral genomic sequences were reported and the proteins encoded

297 x nigra, DN34), a model plant with complete genomic sequence, were hydroponically exposed to 5-hydro

298 coding for post-transcriptional RNA from the genomic sequence with an overall sensitivity of 91% and

299 matics framework to classify metagenomic and genomic sequences with unprecedented accuracy.

300 ncy, transcription factor binding sites, and genomic sequence within an easily navigated user interfa