ライフサイエンスコーパス: genomic sequencing

1 nes not previously identified by traditional genomic sequencing.

2 n enzyme digestion-coupled PCR and bisulfite genomic sequencing.

3 DNA methylation, when analyzed by bisulfite genomic sequencing.

4 ched liver tissues was analyzed by bisulfite genomic sequencing.

5 viruses from pigs as determined by a partial genomic sequencing.

6 nd chromatin structural changes by bisulfite genomic sequencing.

7 as determined from a combination of cDNA and genomic sequencing.

8 USB) from normal leukocyte DNAs by bisulfite genomic sequencing.

9 ch, for instance, can serve as a nucleus for genomic sequencing.

10 rospinal fluid of one, were characterised by genomic sequencing.

11 romosomes (PACs) for comparative mapping and genomic sequencing.

12 Variants were characterized by direct genomic sequencing.

13 valuable tool for gap closure in large-scale genomic sequencing.

14 ing gene structure after the great effort of genomic sequencing.

15 ticles evaluated the entire microbiome using genomic sequencing.

16 es in the human genome will only be found by genomic sequencing.

17 nts, for rapid and accurate mapping, and for genomic sequencing.

18 m tiling paths of BAC clones for large-scale genomic sequencing.

19 tionally cloned or obtained directly through genomic sequencing.

20 e methylation patterns observed by bisulfite genomic sequencing.

21 provide the initial reagents for large-scale genomic sequencing.

22 to application in automated high throughput genomic sequencing.

23 sis has recently shifted towards large-scale genomic sequencing.

24 g of the utility and limitations of pathogen genomic sequencing.

25 with all potential variants confirmed using genomic sequencing.

26 sites within this region by sodium bisulfite genomic sequencing.

27 was determined in the context of large scale genomic sequencing.

28 e nucleotide primer extension, and bisulfite genomic sequencing.

29 g paths of clones for subsequent large-scale genomic sequencing.

30 s including cDNA selection, RT-PCR, RACE and genomic sequencing.

31 nfirmed with the nitrate reductase assay and genomic sequencing.

32 ential components for positional cloning and genomic sequencing.

33 missense mutations were confirmed by direct genomic sequencing.

34 rified the amino acid sequences deduced from genomic sequencing.

35 enotype linkages has been greatly enabled by genomic sequencing.

36 greatly increased the availability of human genomic sequencing.

37 s, selection for function, and deep parallel genomic sequencing.

38 alyses of plant chromosomes, and large-scale genomics sequencing.

39 describe the application of population-based genomic sequencing after chemical mutagenesis to map bac

40 realize the immense potential of large-scale genomic sequencing after the completion of the second hu

41 Empirical data from genomic sequencing along with prospects for combining st

42 Demethylation treatment and bisulfite genomic sequencing analyses revealed that downregulation

43 Large genomic sequencing analysis as part of precision medicin

44 Bisulfite genomic sequencing analysis showed that the normally unm

45 e improvements may permit real-time benchtop genomic sequencing and antimicrobial resistance gene det

46 Using siRNA knock downs, bisulfite genomic sequencing and ChIP, we demonstrate for the firs

47 esidues and histones as judged by bisulphite genomic sequencing and chromatin immunoprecipitation ass

48 p, easy and quick to obtain relative to full genomic sequencing and currently sample more eukaryotic

49 aps should prove valuable as a complement to genomic sequencing and expression-dependent transcript m

50 ablished contig will serve as a template for genomic sequencing and for functional analysis of the GA

51 titutively active Qp, we performed bisulfite genomic sequencing and functional analyses using a methy

52 at specifically target tumours, and aided by genomic sequencing and genetic engineering, there is new

53 lation status was determined using bisulfite genomic sequencing and IL6 messenger RNA (mRNA) levels b

54 se algorithms are being tested in the era of genomic sequencing and it is not clear whether they are

55 ating microarrays, high-throughput bisulfite genomic sequencing and mass spectrometry, as the field m

56 By performing genomic sequencing and methylation-specific PCR assays,

57 provides a solid path forward for population genomic sequencing and offers applications to many other

58 Genomic sequencing and phylogenetic analyses showed that

59 Genomic sequencing and phylogenetic analysis confirmed t

60 Based upon partial genomic sequencing and phylogenetic analysis, the newly

61 tenable in light of recent observations from genomic sequencing and population-genetic theory.

62 Genomic sequencing and structural genomics produced a va

63 nology has previously been applied mainly to genomic sequencing and targeted re-sequencing.

64 e disease locus, followed by high-throughput genomic sequencing and validation by dideoxy sequencing,

65 r by polymerase chain reaction-based, direct genomic sequencing and, where possible, by cosegregation

66 mical staining for mismatch-repair proteins, genomic sequencing, and deletion studies.

67 Using gene mapping, direct genomic sequencing, and extended haplotype analysis, we

68 hybridization reactions, mutation detection, genomic sequencing, and identification of pathogens.

69 ested homozygous deletions, contig building, genomic sequencing, and physical and transcript mapping

70 he starting point for transcription mapping, genomic sequencing, and positional cloning of this regio

71 Using reverse transcription-PCR, bisulfite genomic sequencing, and pyrosequencing, we show that the

72 These studies ultimately led to cloning, genomic sequencing, and the production and phenotypic an

73 d sequence tags or data from high-throughput genomic sequencing, and we describe the methods by which

74 To identify candidate genes, we used shotgun genomic sequencing as well as isolation and analysis of

75 equencing has enabled researchers to perform genomic sequencing at rates that were unimaginable in th

76 High-throughput bisulfite genomic sequencing based on new generation of sequencers

77 red gene expression microarray and bisulfite genomic sequencing-based approach to identify genes that

78 Rice provides advantages for genomic sequencing because of its small genome and its d

79 With greatly increased genomic sequencing being performed for individual patien

80 Comparative human and mouse genomic sequencing between H19 and Igf2 revealed two nov

81 corporate metabolic pathways discovered with genomic sequencing, but direct comparisons between model

82 in sodium channelopathies, the results from genomic sequencing can only be appropriately interpreted

83 Recent progress in genomic sequencing, computational biology, and ontology

84 by methylation-specific PCR and by bisulfite genomic sequencing confirms that the regions identified

85 A new study demonstrates that genomic sequencing coverage of plasma DNA fragments arou

86 nentially with the advent of high-throughput genomic sequencing, creating a significant challenge for

87 lecular cytogenetics, positional cloning and genomic sequencing culminated in a detailed molecular de

88 Further analysis of sequences in undeposited genomic sequencing data and EST databases yielded more t

89 igh accuracy from paired-end high-throughput genomic sequencing data and pinpoints their breakpoints

90 ng capabilities to identify neoantigens from genomic sequencing data are a limiting factor for unders

91 ents, we analyzed non-human sequences in 150 genomic sequencing data files from the 1000 Genomes Proj

92 al and biophysical characteristics (recently genomic sequencing data for both P. furiosus and P. hori

93 The quality of whole-genomic sequencing data is comparable across all samples

94 Analysis of genomic sequencing data requires efficient, easy-to-use

95 In parallel, we also used population genomic sequencing data to compare protein and cis-regul

96 n an ultra-fast, high-throughput manner from genomic sequencing data.

97 By applying laSV to 97 tumor-normal paired genomic sequencing datasets across six cancer types prod

98 ant benefits that continue to be gained from genomic sequencing, dedicated efforts are needed to avoi

99 First, bisulfite genomic sequencing demonstrated that CpG sites within th

100 Genomes Project pilot studies, and targeted genomic sequencing derived from very large sample sizes

101 Primary genomic sequencing determined gene SMCY to be composed o

102 pproaches include screening of biodiversity, genomic sequencing, directed evolution and phage display

103 ng progress of the international Arabidopsis genomic sequencing effort, AGI (the Arabidopsis Genome I

104 will, in the short term, aid in prioritizing genomic sequencing efforts and in interpreting sequencin

105 representation of racial minorities in large genomic sequencing efforts is unclear, and could have an

106 a significant cost saving in high throughput genomic sequencing efforts.

107 In the post-genomic sequencing era, an expanding portfolio of genomi

108 Sodium bisulfite genomic sequencing established that a CpG-rich island wi

109 r biobanks are integrating more tightly with genomic sequencing facilities and with those creating an

110 further confirmed by Western blot, although genomic sequencing failed to reveal conclusive PLCZ1 mut

111 ven to clinical testing of PALB2 by complete genomic sequencing for familial breast cancer patients w

112 were identified by cDNA selection and direct genomic sequencing from the familial dysautonomia candid

113 Genomic sequencing has driven precision-based oncology t

114 Genomic sequencing has identified three different typica

115 Genomic sequencing has implicated large numbers of genes

116 The throughput of genomic sequencing has increased to the point that is ov

117 ing binding ligands to targets identified by genomic sequencing has led to a bottleneck in genomic re

118 The recent explosion in genomic sequencing has made available a wealth of data t

119 Although genomic sequencing has provided a better understating of

120 early stages in the vertebrate lineage, but genomic sequencing has recently revealed extensive ampli

121 However, recent genomic sequencing has revealed PDF-like sequences in ma

122 Further, recent explosion in genomic sequencing has revealed recurrent ACK1 gene ampl

123 Additionally, genomic sequencing has revealed the complexity of the ca

124 Recent genomic sequencing has shown that Caenorhabditis elegans

125 Genomic sequencing has substantial epidemiologic value i

126 tic mutation genotyping and massive parallel genomic sequencing have become increasingly feasible at

127 Restriction enzyme analysis and genomic sequencing identified 2 clusters of closely rela

128 Genomic sequencing identified an A-->T transversion at t

129 ceptor, and database searches and additional genomic sequencing identified five maize homologs includ

130 Genomic sequencing identified one retro-transposon-like

131 from our stocks of these two strains, total genomic sequencing identified several unique nonsynonymo

132 Genomic sequencing identified three distinct in-frame de

133 Genomic sequencing identified two different heterozygous

134 of the paternal SMPD1 allele, and bisulfite genomic sequencing identified which CpG dinucleotides wi

135 this region have been used as templates for genomic sequencing in an effort to identify candidate ge

136 on of five genes was quantified by bisulfite genomic sequencing in d-200 dorsal prostates across BPA

137 erine metabolism and highlights the power of genomic sequencing in revealing the unsuspected allelic

138 Genomic sequencing in the region of the FRT site (follow

139 sential tool for both positional cloning and genomic sequencing in this key model system for biomedic

140 Unexpected results from genomic sequencing indicate that significant intrastrain

141 Recent evidence from genomic sequencing indicates a 15-year interval for gene

142 We exploited the detailed genomic sequencing information of a large number of Arab

143 era of "next-gen cytogenetics," integrating genomic sequencing into the prenatal diagnostic setting

144 Targeted comparative genomic sequencing is a complementary approach to whole-

145 Bisulphite genomic sequencing is a widely used technique for detail

146 This study demonstrates that large-scale genomic sequencing is an efficient approach to analyze t

147 hree potential EPS gene clusters revealed by genomic sequencing is an important component of P. aerug

148 sorders, and targeted and massively parallel genomic sequencing is beginning to be used in clinical p

149 The translational utility of genomic sequencing is clear, from understanding of human

150 Genomic sequencing is no longer a novelty, but gene func

151 Large scale genomic sequencing is now widely used to decipher questi

152 Concurrently, genomic sequencing is uncovering thousands of previously

153 or Friedlin genome has been constructed, and genomic sequencing is well underway.

154 rapy-resistant brain tumours, which, despite genomic sequencing, lack effective molecular targets.

155 Predicting the molecular complexity of a genomic sequencing library is a critical but difficult p

156 By genomic sequencing, linkage analysis, and functional val

157 A mapping is an important analytical tool in genomic sequencing, medical diagnostics and pathogen ide

158 sites methylated in vivo using the bisulfite genomic sequencing method confirms the previous finding

159 , we have used the more definitive bisulfite genomic sequencing method to examine CpG methylation in

160 e report here a new, sensitive and versatile genomic sequencing method, which can be used for in vivo

161 ia (BPH) tissues samples using the bisulfite genomic sequencing method.

162 ng nearest neighbor technique and bisulphite genomic sequencing methods to investigate the nearest ne

163 n completely sequenced using various PCR and genomic-sequencing methods.

164 Genomic sequencing might help to establish a diagnosis,

165 ) to guide decisions regarding the amount of genomic sequencing necessary to develop high-quality dia

166 Genomic sequencing now brings finer resolution to both b

167 Genomic sequencing now shows that this variant (variant

168 Recent genomic sequencing of 10 additional Drosophila genomes p

169 he STK11/LKB1 gene were analysed with direct genomic sequencing of 15 HNSCC specimens.

170 nts with muscle biopsy-proven MTM, by direct genomic sequencing of 92% of the known coding sequence o

171 High-throughput genomic sequencing of a conservative estimate (24.2 Mb)

172 Finally, genomic sequencing of a cosmid containing the complete n

173 With the completion of the genomic sequencing of a number of species, including tha

174 The high rate of detection of mutations by genomic sequencing of ALK-1 suggests that this will be a

175 any TNFRSF1A mutation, despite comprehensive genomic sequencing of all of the exons, therefore sugges

176 With the genomic sequencing of Arabidopsis nearing completion and

177 Direct genomic sequencing of bacterial 16S rRNA genes to query

178 Genomic sequencing of bacterial pathogens is providing a

179 Genomic sequencing of BMPR1A in each of these JP kindred

180 pression in normal and cancerous tissue, and genomic sequencing of candidate.

181 Genomic sequencing of CDV isolated from one of the infec

182 Genomic sequencing of Chlamydia indicated this medically

183 Bisulfite genomic sequencing of DNA from oocytes and embryos showe

184 Genomic sequencing of ETH76a revealed a relatively small

185 Recent intensive genomic sequencing of hematopoietic malignancies has ide

186 entation are preliminary, as high-throughput genomic sequencing of HSA17q-ter has not been fully comp

187 fined the methylation status of every CpG by genomic sequencing of individual cloned copies of bisulf

188 Unlike A. trivirgatus, genomic sequencing of M. nemestrina and M. fascicularis

189 The complete genomic sequencing of Methanococcus jannaschii cannot id

190 being generated by the accelerating pace of genomic sequencing of microbes.

191 We confirmed this hypothesis by genomic sequencing of progeny from young and old plants.

192 yeast nuclear gene RML2, identified through genomic sequencing of Saccharomyces cerevisiae chromosom

193 Analysis of haplotype blocks and genomic sequencing of Scg5 in high (C3H/HeJ, DBA/2J, BAL

194 The recent genomic sequencing of Selaginella, a member of the lycop

195 Genomic sequencing of several of these pathogens is unde

196 Genomic sequencing of splice junction regions of the Ika

197 Using genomic sequencing of synthetic and natural allopolyploi

198 Sequence variants were identified by genomic sequencing of the 12 ANKH exons and their flanki

199 Full length genomic sequencing of the 2010 H14 isolates demonstrated

200 ken together, compared with that in mammals, genomic sequencing of the catfish TCR DB-JB-CB region re

201 Bisulfite genomic sequencing of the CpG island encompassing exon 1

202 ATP/ADP translocase was uncovered during the genomic sequencing of the intracellular plant pathogen "

203 mes, methylation-specific PCR, and bisulfite genomic sequencing of the polymorphic CAG repeat site of

204 Bisulfite genomic sequencing of the rubq2 promoters revealed speci

205 Partial genomic sequencing of their available poliovirus isolate

206 By genomic sequencing of these T-cell clones, we identified

207 be the starting resource for the large-scale genomic sequencing of this region by The Sanger Center,

208 d 5 BACs, which will facilitate the complete genomic sequencing of this region of chromosome 6.

209 In combination with the genomic sequencing of tumors in patients, the yeast-base

210 The comparative-genomic sequencing of two Mycobacterium tuberculosis str

211 Genomic sequencing on 36 paired normal and cervical tumo

212 With the advent of complete genomic sequencing on the horizon, Drosophila will conti

213 recent success of large-scale industrialized genomic sequencing opens new doors in studies of biologi

214 zed open reading frames (ORFs) identified by genomic sequencing or represented in EST databases.

215 er (up to 5,000) tandem gene arrays has made genomic sequencing problematic.

216 pid mapping of DNA sequences and large-scale genomic sequencing programs.

217 After an in silico search of the P. carinii genomic sequencing project identified a 329-bp partial s

218 -sequencing project and an 8X random shotgun genomic sequencing project.

219 osome III sequences reported by the nematode genomic sequencing project.

220 eriments, provide substrates for large-scale genomic sequencing projects and facilitate the mapping o

221 As genomic sequencing projects attempt ever more ambitious

222 Large-scale genomic sequencing projects have provided DNA sequence i

223 the choice for clone sets in high throughput genomic sequencing projects primarily because of their h

224 Recent genomic sequencing projects, however, have identified pu

225 are being predicted by large scale cDNA and genomic sequencing projects, with levels of evidence ran

226 it" synthetases that are now identified from genomic sequencing projects.

227 acellular matrix proteins identified through genomic sequencing projects.

228 xpression pattern of sequences obtained from genomic sequencing projects.

229 m to guide decisions regarding the amount of genomic sequencing required to develop diagnostic DNA si

230 Large-scale genomic sequencing requires a software infrastructure to

231 However, genomic sequencing results suggest that many DNA repair

232 ells but not in NP, confirming the bisulfite genomic sequencing results.

233 ents also showed exon 3 skipping, and later, genomic sequencing revealed a mutation deep in intron 2.

234 Genomic sequencing revealed compound heterozygous mutati

235 Genomic sequencing revealed noncoding polymorphism in bo

236 Bisulfite genomic sequencing revealed that (S)G treatment universa

237 Bisulfite genomic sequencing revealed that all 21 CpG dinucleotide

238 Bisulfite genomic sequencing revealed that all 21 CpG dinucleotide

239 DNA methylation profiling and bisulfite genomic sequencing revealed that KLF4 expression reduced

240 Detailed methylation mapping using bisulfite genomic sequencing revealed that loss of expression of C

241 Genomic sequencing revealed that NI1060 is a mouse-speci

242 Methylation-specific PCR and bisulfite genomic sequencing revealed that the RASSF1A promoter wa

243 five affected siblings, linkage analysis and genomic sequencing revealed the genetic basis of Perraul

244 Genomic sequencing reveals a common region in RFC1p, RFC

245 Genomic sequencing reveals an ancient haplotype split at

246 As genomic sequencing reveals the range of structural class

247 Genetic mapping, complementation tests, and genomic sequencing show that brec mutations disrupt a pr

248 Bisulfite genomic sequencing showed significant (>90%) demethylati

249 Ligation-mediated PCR genomic sequencing showed that all CpG dinucleotides exa

250 be entirely CpG methylated in BL, bisulfite genomic sequencing showed virtually no methylation in Qp

251 Here we present single-cell genomic sequencing (SiC-seq), which uses droplet microfl

252 The underlying error rate for genomic sequencing sometimes results in the introduction

253 y-based designs are regaining popularity for genomic sequencing studies because they provide a way to

254 Partial genomic sequencing studies indicated that at least 15 ou

255 Genomic sequencing studies of breast and other cancers h

256 These studies, in conjunction with other genomic sequencing studies of X-linked genes, demonstrat

257 zed, while a second gene was identified in a genomic sequencing study but not analyzed biochemically.

258 Recently, a large-scale genomic sequencing study of ccRCC tumors revealed that e

259 A tag-modified bisulfite genomic sequencing (tBGS) method employing direct cycle

260 n polymorphism (SSCP) technique and a direct genomic sequencing technique were used to screen all 22

261 n polymorphism (SSCP) technique and a direct genomic sequencing technique were used to screen the cod

262 ts many advantages, scRNAseq, like any other genomic sequencing technique, is susceptible to the infl

263 onformation polymorphism analysis and direct genomic sequencing techniques were used to screen 272 un

264 onformation polymorphism analysis and direct genomic sequencing techniques were used to screen 596 un

265 Advances in genomic sequencing technologies have improved the abilit

266 one of 11 HPyVs recently discovered through genomic sequencing technologies.

267 Innovations in both tumor genomic sequencing technology and the development of dru

268 With advances in genomic sequencing technology, the number of reported ge

269 e exploit bisulfite mutagenesis coupled with genomic sequencing to derive the methylation status of 6

270 highlight the utility of massively parallel genomic sequencing to discover novel translocations in l

271 In this study, we have used targeted genomic sequencing to evaluate the contribution of genet

272 action of this insulator, we used bisulfite genomic sequencing to examine the methylation of individ

273 We used cDNA selection, exon trapping, and genomic sequencing to identify 12 transcription units fr

274 Standard genomic sequencing to identify all heterozygous SNPs in

275 We used genomic sequencing to identify potentially pathogenic ge

276 used cDNA selection, exon amplification, and genomic sequencing to identify three novel transcripts (

277 The use of genomic sequencing to investigate microbes has expanded,

278 on and gene transcription, we used bisulfite genomic sequencing to obtain a detailed analysis of meth

279 ill be increasingly reliant on comprehensive genomic sequencing to reveal the spectrum of genetic alt

280 We used genomic sequencing to understand the establishment and d

281 Comparison of the results of genomic sequencing versus reverse-transcriptase polymera

282 Complete genomic sequencing was carried out on nine purified stra

283 Extensive genomic sequencing was performed in an effort to underst

284 rated index-cell sorting and high-throughput genomic sequencing, we are able to analyze genomic seque

285 Through bisulfite genomic sequencing, we demonstrated that, although CD49d

286 Using bisulfite genomic sequencing, we did not find a generalized patter

287 Using semiquantitative RT-PCR and bisulfite genomic sequencing, we established an inverse relationsh

288 Upon bisulfite genomic sequencing, we found that 3 CpG sites in the bet

289 Using bisulfite genomic sequencing, we have assessed the methylation sta

290 sing targeted capture and massively parallel genomic sequencing, we screened for germ-line mutations

291 analysis and ligation-mediated PCR-assisted genomic sequencing, we show that HiNF-P interacts with c

292 By genomic sequencing, we showed that four out of six of th

293 ANKH variants identified by genomic sequencing were screened for association with ch

294 tion polymorphism (SSCP) analysis and direct genomic sequencing were used to evaluate the coding regi

295 We identified a minimal overlap contig for genomic sequencing, which has yielded 7.7 Mb of finished

296 volution and behavior with lemur comparative genomic sequencing will offer insights into many levels

297 ate the feasibility of performing high-speed genomic sequencing with microfabricated electrophoretic