ライフサイエンスコーパス: genotype

1 pth (hierarchical structure of phenotype and genotypes).

2 .94) when reinfected with a heterologous HCV genotype.

3 ralization was largely toward the homologous genotype.

4 es dd-cfDNA levels in the absence of a donor genotype.

5 s into the cell's phenotype and links to its genotype.

6 t considering the role of HCV viral load and genotype.

7 ia) as well as presence of the APOE epsilon4 genotype.

8 BOC patients taking into account their BRCA1 genotype.

9 ins) canine colony, irrespective of the MAP9 genotype.

10 ns that are linked to dystonia phenotype and genotype.

11 ning fluid composition independent of age or genotype.

12 ecture in AD and IV HEEs, independent of FLG genotype.

13 one SNP in the SULT2A1 gene (rs182420) were genotyped.

14 nts is compared in seeds of two pearl millet genotypes.

15 quations to predict heading date from marker genotypes.

16 ks to correlate imaging features with cancer genotypes.

17 tance decreased at similar levels in the two genotypes.

18 consisting of multiple genera, species, and genotypes.

19 ortional to the survival rate of mice across genotypes.

20 ocaine administration did not differ between genotypes.

21 and the fitness associated with reassortant genotypes.

22 effective treatment duration across multiple genotypes.

23 d transmission in pigs of six representative genotypes.

24 dant with the distribution of microsatellite genotypes.

25 virus was observed in less susceptible host genotypes.

26 were decreased in response to aphids in all genotypes.

27 tency against heterologous viral strains and genotypes.

28 ation, predicting levels of robustness among genotypes.

29 luence technologies ranging from printing to genotyping.

30 re assessed by droplet digital PCR or Taqman genotyping.

31 dentified 7 HPV types not included in the LA genotyping.

32 ir/sofosbuvir (LDV/SOF) can be considered in genotype 1 hepatitis C virus-infected patients who are t

33 ort use of this therapy in patients with HCV genotype 1 infection and stage 4-5 chronic kidney diseas

34 104 patients enrolled in the trial, 52% had genotype 1 infection, 16% had genotype 2 infection, 11%

35 onse to PEG-IFN-based therapy in chronic HCV genotype 1 infection.

36 edipasvir-sofosbuvir for patients with acute genotype 1 or 4 HCV infection and HIV-1 coinfection is s

37 is safe and effective for patients with HCV genotype 1 or 4 infections.

38 Patients with HCV genotype 1 tended to have a higher risk of developing ES

39 2.9% with HCV genotype 1; 66.7% with HCV non-genotype 1).

40 led patients aged 18 years or older with HCV genotype 1, 2, 4, 5, or 6 infection and compensated cirr

41 ed women (aged 18-65 years) with chronic HCV genotype 1, 3, or 4 infection diagnosed at least 24 week

42 NS5A from genotype 2 HCV, and not that from genotype 1, targets NAP1L1 for proteosome-mediated degra

43 chieved by 60.5% of patients (52.9% with HCV genotype 1; 66.7% with HCV non-genotype 1).

44 ve study participants for all panel members (genotypes 1 to 4).

45 y-two chronic HCV patients infected with HCV genotypes 1, 3, and 4 received a single subcutaneous adm

46 tries who were chronically infected with HCV genotypes 1-6 (HCV RNA >/=10 000 IU/mL) with or without

47 n (C/C genotype: 16792 +/- 1607, n = 22, C/T genotype: 11221 +/- 1245, n = 18 T/T genotype: 11543 +/-

48 22, C/T genotype: 11221 +/- 1245, n = 18 T/T genotype: 11543 +/- 6054, n = 3, all values expressed as

49 ated with higher islet Zn concentration (C/C genotype: 16792 +/- 1607, n = 22, C/T genotype: 11221 +/

50 Seventy-two percent of the patients had HCV genotype 1a infection.

51 mbinant strain HCV1 (hepatitis C virus [HCV] genotype 1a) gpE1/gpE2 (E1E2) vaccine candidate was prev

52 Genotype 1b dominates in east Asia, whereas in south Asi

53 ut (KO) pigs are resistant to infection with genotype 2 (type 2) porcine reproductive and respiratory

54 However, only NS5A from genotype 2 HCV, and not that from genotype 1, targets NA

55 trial, 52% had genotype 1 infection, 16% had genotype 2 infection, 11% had genotype 3 infection, 19%

56 is highly effective for the treatment of HCV genotype 2.

57 ia, whereas in south Asia and southeast Asia genotype 3 dominates, and in Indochina (Vietnam, Cambodi

58 d sofosbuvir plus ribavirin in patients with genotype 3 HCV infection.

59 ction, 16% had genotype 2 infection, 11% had genotype 3 infection, 19% had genotype 4 infection, and

60 In patients with HCV genotype 3, Y93H was associated with resistance to dacla

61 ited efficacy of ledipasvir in patients with genotype 3.

62 tile, QT increased 7 ms across the CC and TT genotypes: 397 (95% confidence interval: 396, 399) to 40

63 safe treatment option for patients with HCV genotype 4 infection in preliver and postliver transplan

64 ction, 11% had genotype 3 infection, 19% had genotype 4 infection, and 2% had genotype 5 or 6 infecti

65 those with either the C/T (51.8%) or the T/T genotype (47.3%).

66 on, 19% had genotype 4 infection, and 2% had genotype 5 or 6 infection.

67 in Indochina (Vietnam, Cambodia, and Laos), genotype 6 is most common.

68 e full genome of both a novel subtype of HCV genotype 6, and a co-infecting human pegivirus.

69 the prevalence of human papillomavirus (HPV) genotypes 6, 11, 16, and 18 in women and girls aged </=2

70 Using geolocated genotype (800 cases) and serotype (17,291 cases) data, w

71 In 6 patients (2%) with the CT genotype, a SPINK1 gene mutation was found, while in the

72 and placebo did not significantly differ by genotype alone.

73 Plasma cfDNA genotyping also allowed for the recovery of mutations th

74 IL28B-CC genotype and 12-month postpartum undetectable viremia we

75 nd determined risk of MCI and/or dementia by genotype and baseline age.

76 nificant relationship between rs3217869 risk genotype and decreased CCND2 expression levels in a coll

77 alent metals in human islets with rs13266634 genotype and demographic characteristics.

78 Here we use the genotype and DNA methylation (DNAm) data from cord blood

79 This joint analysis of genotype and DNAm demonstrates the potential of both bra

80 analysis should involve the apolipoprotein E genotype and intervening conditions during trial.

81 ompounds present in cocoa beans depending on genotype and origin.

82 F/VEL and how this differed depending on the genotype and patient population.

83 precision medicine, bridging the gap between genotype and phenotype in an in vivo setting.

84 Understanding the relation between genotype and phenotype remains a major challenge.

85 be affected by interactions between the APOE genotype and plasma fatty acids (FA).

86 icacy and not haemolysis in relation to G6PD genotype and that the heterozygote groups were small.

87 ting the key claim of an interaction between genotype and treatment.

88 AA participants in the Partners Biobank were genotyped and used for validation.

89 bodies against VLPs from multiple GI and GII genotypes and found that the synbodies were broadly cros

90 CV) therapies with excellent efficacy across genotypes and in diverse populations.

91 apies is comparable across all p53-deficient genotypes and may explain the high incidence of p53 loss

92 RNAs, observed upon drought and in different genotypes and organs, were confirmed by RT-qPCR Correspo

93 e in detail the complex relationship between genotypes and phenotypes with both theoretical and pract

94 Parasite genotyping and drug concentrations were investigated in

95 vels were measured from plasma, and both DNA genotyping and mRNA expression levels in peripheral bloo

96 Pyrosequencing genotyping and sequencing of the voltage gated sodium ch

97 irst on single nucleotide polymorphism (SNP) genotyping and then with whole-genome data and show how

98 and metabolites were changed in response to genotype, and cell wall composition was largely unaffect

99 in patients' cells, depending on their GINS1 genotype, and correlated with the severity of growth ret

100 riable models including age, sex, race, APOE genotype, and educational level.

101 cribe the baseline clinical characteristics, genotypes, and determinants of disease severity in a lar

102 s a highly discriminatory assay for B. canis genotyping, and can serve as a useful molecular epidemio

103 combined whole-exome sequencing, array-based genotyping, and linkage analysis to identify putative pa

104 the incorporation of apolipoprotein epsilon4 genotype (APOE epsilon4) information, increased to 86% w

105 For flexibility in genotyping applications, SNPs polymorphic between tetrap

106 ositive calls, we present a method that uses genotype array data from the sequenced samples, rather t

107 available Illumina Infinium ShrimpLD-24 v1.0 genotyping array.

108 . thaliana phyllosphere correlated with HOL1 genotype, as shown by qPCR and RT-qPCR.

109 ith T1D were enrolled if they had 1 of 9 HLA genotypes associated with a risk for T1D.

110 tly associated with specific pairings of the genotype at codon 129 of the prion protein gene and conf

111 solidation), MRD detection method, phenotype/genotype (B cell, T cell, Philadelphia chromosome), and

112 We found that patient MHC-I genotype-based scores could predict which mutations were

113 opurine methyltransferase enzyme activity or genotype before starting thiopurine therapy compared wit

114 erlin Potsdam study (p = 0.012), with the GG-genotypes being significantly associated with prevalent

115 s were observed for lesions with IDH-mutated genotypes, between astrocytoma and oligodendroglioma his

116 rms functional (Fix(+)) nodules on one plant genotype but nonfunctional (Fix(-)) nodules on another.

117 ximide significantly blocks seizures in both genotypes, but the abnormal phase-amplitude coupling rem

118 Genotyping by sequencing identified 14,059 segregating p

119 These results uncovered genotype-by-environment interactions that support a poly

120 We found that the diabetes risk genotype C/C at rs13266634 is associated with higher isl

121 ith a deleterious mutation in a 'tri-allelic genotype' can account for missing heritability in some h

122 hildren (but not toddlers or adults) with AC genotype carried parasites, including gametocytes, more

123 of functional HvCERK1 gene in the resistant genotype CI9831, followed by gene expression and metabol

124 Modeling of phenotypes for multilocus genotype classes in the epistatic networks is often impr

125 a WHO international reference panel for HEV genotypes (code 8578/13) showed viral load results falli

126 who are carriers of the haptoglobin (Hp) 1-1 genotype compared with noncarriers.

127 etabolite, are reduced in women whose CYP2D6 genotypes confer poor enzyme function.

128 To study phenotype/genotype correlations, we performed genetic analyses by

129 escribe a distant evolutionary branch within genotype D4.

130 via extensive simulation studies using real genotype data and an analysis of genetic data from the O

131 We obtained high-density genotype data from [Formula: see text] DO mice, and loca

132 In the analysis of published genotype data from the Simons Simplex Collection (SSC) a

133 We compiled publicly available genome-wide genotype data on 5,966 individuals from 282 global sampl

134 In addition, ChIA-PET2 can use phased genotype data to call allele-specific chromatin interact

135 Using genotype data to perform accurate genetic prediction of

136 lished psychiatric diagnoses and genome-wide genotype data.

137 kage disequilibrium estimated from reference genotype data.

138 The results obtained from simulated and real genotype datasets showed that the ELS algorithm was able

139 w major features: (i) handling of very large genotyping datasets like the ones generated by GBS; (ii)

140 In both cell types, we found genotype-dependent differences for rs13082711 in DNA-nuc

141 Tuba-seq uncovers genotype-dependent distributions of tumor sizes.

142 plication occur in a prion protein codon 129 genotype-dependent manner, reflecting the genotype-depen

143 29 genotype-dependent manner, reflecting the genotype-dependent susceptibility to clinical vCJD found

144 TMEM106B genotype did not influence grey matter volume directly o

145 ntly as metabolites differentiated genotype, genotype-differentiating metabolites could potentially p

146 nificant selection can also occur on haploid genotypes during less conspicuous life cycle stages, e.g

147 Genotype effects were not observed in frontotemporal GM

148 We report that a novel emm32.2 genotype emerged in Liverpool in 2010 and identified a s

149 Genotype expression and its further correlation with CSU

150 , we found that transformation into a mutant genotype followed by introgression into the wild type do

151 gnificant association was detected: the case genotype for rs72820264, an intragenetic single-nucleoti

152 mples from four distant basins in Chile were genotyped for 13 microsatellite loci, and allocated, thr

153 Patients were genotyped for functional variants on vitamin D synthetic

154 s from 696 CBUs with malignant diseases were genotyped for NLRP1, NLRP2, NLRP3, TIRAP/Mal, IL10, REL,

155 Consumers were genotyped for TAS2R38 status to determine if liking is i

156 Patients were genotyped for the following polymorphisms: VKORC1-1639G>

157 cis- and trans-regulatory variation between genotypes for both steady-state and stress-responsive ex

158 Subjects with susceptibility genotypes for celiac disease and type 1 diabetes were fo

159 To evaluate the accuracy of genotyping for HPV types 16 and 18 and its utility as a

160 we exposed F2 hybrids, used to separate Eda genotype from genetic background, to contrasting conditi

161 Multilocus genotypes from 7 microsatellite loci suggested that most

162 Here, we integrated genome-wide genotype, gene expression, viremia level, and weight gai

163 Importantly as metabolites differentiated genotype, genotype-differentiating metabolites could pot

164 To determine whether genotype-guided dosing improves the safety of warfarin i

165 Patients with the CC genotype had significantly lower relapse risk in the GO

166 Subjects with asthma and the AA/AG genotypes had a 5% decrease in FEV1 /FVC (P<.001).

167 stry and polymerase chain reaction-based DNA genotyping have emerged as powerful diagnostic methods f

168 ngue virus, distinguish pathogenic bacteria, genotype human DNA, and identify mutations in cell-free

169 sed by genotype II, although two isolates of genotype I were also detected for the first time in Rio

170 is indicates that the outbreak was caused by genotype II, although two isolates of genotype I were al

171 not with years of education, gender, or APOE genotype; (ii) increased annualized change in florbetapi

172 We report a lack of cross-genotype immunity in the largest cohort of people to dat

173 .664 trimers of the DU422, 426c, and 92UG037 genotypes.IMPORTANCE Recombinant trimeric proteins based

174 Genotyping, imputation, and genome-wide association stud

175 that the female subjects with high frequent genotype in GAL3ST4 had a fivefold elevated expression.

176 These variants were also genotyped in all family members to establish genotype-ph

177 ach follow-up visit, and LMX1A-rs4657412 was genotyped in all participants.

178 HDV strains were prospectively collected and genotyped in our reference laboratory by means of nucleo

179 s hardly possible to measure fitness for all genotypes in a natural population.

180 there was a co-circulation of BA and non-BA genotypes in China.

181 pes emphasize the importance of subtypes and genotypes in designing nonsurgical therapeutic strategie

182 variants in endometriosis using exome-array genotyping in 7164 cases and 21005 controls, and a repli

183 ptured using exome-sequencing and exome-chip genotyping in a genetically isolated population from the

184 compounds were identified in Saskatoon berry genotypes, including twenty-nine polyphenolic compounds

185 all confounders indicated that the PEPT2*1*1 genotype independently associated with an eGFR<60 ml/min

186 Further genotyping indicated that a single non-synonymous substi

187 al striatum, such that the normal (vs. slow) genotype individuals showed greater functional connectiv

188 Our studies suggest that ACTN3 R577X genotype is a modifier of clinical phenotype in DMD pati

189 s the phenotypic variation of a trait when a genotype is exposed to different environments.

190 The penetrance of genotype is however variable and influenced by dietary f

191 iciency virus type 1 (HIV-1) drug resistance genotyping is recommended to help in the selection of an

192 Unlike NS3 variants from other genotypes, JFH-1 NS3 binds RNA with high affinity in a f

193 lanced within each serotype, suggesting that genotype-level heterogeneity may be limited in older chi

194 However, certain rice genotypes like Nonabokra and Pokkali show a high level o

195 enous traits, such as resistance, among host genotypes may offer redundancy and generally limit the i

196 A number of factors, including age, sex, and genotype, may affect these metabolic processes.

197 standing of specific diabetes phenotypes and genotypes might result in more specific and tailored man

198 Genotype (multilocus sequence type) and fluoroquinolone

199 alpha-Galactosidase A genotype N215S does not lead to the development of a cla

200 individual and total phenols were found for genotypes native to Mexico (like RIM105, M031, and M033)

201 METHOD: We genotyped nine IL13 "tag" single nucleotide polymorphism

202 stressors (strong risk factor) and 5-HTTLPR genotype (no impact on risk) are strikingly consistent a

203 etween September 2013 and August 2016, 2,715 genotyped norovirus outbreaks were submitted to CaliciNe

204 Cox P = .002) and for the intermediate risk genotype NPM1 wild-type/FLT3 without internal-tandem dup

205 ependent on the temperature and mito-nuclear genotype of the mother.

206 Genotypes of 12 markers obtained from 268 CBE patients o

207 our on a small server with 10 CPUs to access genotypes of approximately 60 million variants of 2504 s

208 efficacy and transferability across patient genotypes of this approach.

209 These results demonstrate that cfDNA genotyping of DLBCL is as accurate as genotyping of the

210 Accurate and efficient genotyping of simple sequence repeats (SSRs) constitutes

211 cfDNA genotyping of DLBCL is as accurate as genotyping of the diagnostic biopsy to detect clonally r

212 Genotyping of the rs660895 polymorphism in the HLA-DRB1

213 ) educational attainment; and (iii) TMEM106B genotype on grey matter volume.

214 In this study, the impact of host genotype on growth response to mycorrhizal inoculation w

215 atients carrying the IFNL4 rs368234815 TT/TT genotype (P < 0.05).

216 ncy virus (HIV)-uninfected patients, with TT-genotype patients significantly more likely to survive T

217 ificantly more likely to survive TBM than CC-genotype patients, according to Cox regression analysis

218 s have not been thoroughly examined, and the genotype-phenotype association has not been established.

219 investigate prognostic image biomarkers and genotype-phenotype associations.

220 h nephrotic syndrome (NS) and to determine a genotype-phenotype correlation in this disease.

221 trum, study levels of mosaicism and identify genotype-phenotype correlations of AKT3-related disorder

222 rain defects, and the potential existence of genotype-phenotype correlations, all of which are contes

223 arrants caution when making assertions about genotype-phenotype correlations.

224 genotyped in all family members to establish genotype-phenotype cosegregation.

225 ion, but emerge from the nonlinearity of the genotype-phenotype curve.

226 n OGID and cancer differ, suggesting complex genotype-phenotype relationships.

227 se, and absence of previous documentation of genotype-phenotype segregation, our findings suggest tha

228 Furthermore, we summarize genotype-phenotype studies based first on single nucleot

229 In this large, prospective, genotype-phenotype study of ambulatory DCM patients, we

230 Nef genotype/phenotype analyses in a cohort of HIV-1 subtype

231 Knowledge about this genotype/phenotype correlation is relevant to adjusting

232 e editing with an innovative high-throughput genotyping pipeline utilizing KASP (Kompetitive Allele-S

233 by building a transmission map, completed by genotyping Pneumocystis isolates and by a control of che

234 rmined in 27 asymptomatic mutation carriers (genotype positive/phenotype negative), 10 patients with

235 LTA4H genotype predicted survival of human immunodeficiency vi

236 fication success) can be used as a proxy for genotype quality, allowing the reduction of replication

237 in grapevine (Vitis vinifera) that different genotypes ranging from near isohydric to more anisohydri

238 uld have a significantly lower average false genotype rate than using whole-exome sequencing to asses

239 ion on fat-mass and obesity-associated (FTO) genotype risk had a greater effect on a reduction of obe

240 pe mothers, we showed that both inoculum and genotype shape microbiota populations in the offspring.

241 as erupted in recent years regarding whether genotyping should be part of standard care for patients

242 Both genotypes showed decreasing pore space between 0.8 and 0

243 uijn graph, which is aimed at 'detecting and genotyping simple and complex genetic variants in an ind

244 ort, TOF was significantly associated with a genotyped single-nucleotide polymorphism (rs12519770, P=

245 BKV genotype-specific NAb titers may be a meaningful predict

246 rted that two strains displayed rhythms with genotype-specific periodicity, in agreement with their o

247 preferences of individual 2A(pro) predict RV genotype-specific targeting of NPC pathways and cargos.

248 Accounting for CYP2D6 genotype status did not change these estimates.

249 t cancer patients and, consequently, CYP2C19 genotype status should not be included in clinical decis

250 se detected QTLs, we estimate that recall-by-genotype studies that use iPSC-derived cells will requir

251 increase in the risk of advanced AMD in some genotype subgroups.

252 Genotyping suggests that capsular switching has occurred

253 here has been limited evidence about whether genotype-tailored advice provides extra benefits in redu

254 izing KASP (Kompetitive Allele-Specific PCR) genotyping technology to create scarless isogenic cell m

255 eriments with Potato virus Y (PVY) in potato genotypes that differ in their defense response against

256 Genotypes that predict higher plasma efavirenz exposure

257 remaining 242 families revealed 2 additional genotypes that were invisible by the other methods.

258 ties/differences in Asians and Europeans, we genotyped the 10 novel single nucleotide polymorphisms (

259 Using germline genotypes, the heritability of breast cancer subtypes (b

260 nd multi-tissue RNA-sequencing data from the Genotype-Tissue Expression (GTEx) project v6p release.

261 nd we demonstrate its use with data from the Genotype-Tissue Expression (GTEx) project.

262 MT3B expression in adult cerebellum from the Genotype-Tissue Expression project (N=103, P=3.0 x 10(-6

263 which could have allowed this novel emm32.2 genotype to persist in a disadvantaged population in the

264 each patient is a new method of translating genotype to phenotype.

265 mbinations of maternal and embryo SERT Ala56 genotypes to examine effects on blood, placenta and embr

266 50 resequenced genomes from diverse sorghum genotypes to the reference genome identified approximate

267 We aimed to use molecular genotyping to assess antimalarial drug resistance select

268 We used microsatellite genotyping to assess genetic relatedness.

269 erized across different harvests, organs and genotypes, to generate a representative reference profil

270 m treatment, we were unable to replicate any genotype-treatment interactions after adjusting for mult

271 ropean-ancestry individuals from 30 cohorts, genotyped using the Exome Chip.

272 antigenic sites in MeV-H, we identified a D4 genotype variant that escapes neutralization by MAbs tar

273 Samples were genotyped via microarray, and SNPs that could not be gen

274 The prevalence of any HPV genotype was 45.3% on the penis, 11.2% in the oral cavit

275 This genotype was also associated with increased susceptibili

276 Results The rs12459419 genotype was CC in 415 patients (51%), CT in 316 patient

277 the FEV1 /FVC ratio associated with the risk genotype was modified by asthma status.

278 In contrast, no effect of embryo genotype was seen in concepti from heterozygous dams.

279 The frequency of the FCGR3A-VV genotype was significantly higher in the CAV(+) group (o

280 A new MLVA-13Bc method for B. canis genotyping was established by combining eight newly-deve

281 Genotyping was performed in 377 children from the at-ris

282 Genotyping was performed on a subsample of 1284 AMD case

283 Individuals with the rs2242446 C/C genotype were more likely to remit (73.1%) than those wi

284 d via microarray, and SNPs that could not be genotyped were imputed.

285 ates were genotypically unrelated, and their genotypes were common among isolates of the same serotyp

286 HbAA, HbAC, and HbAS genotypes were determined and tested for association wit

287 profiles for different clones within almond genotypes were developed to examine their association wi

288 Genome-wide genotypes were imputed to the 1000 Genomes reference pan

289 d catechol-O-methyltransferase (COMT) rs4680 genotypes were measured.After multivariable adjustment,

290 The most common genotypes were p.R120W (in 81% of patients with autosoma

291 xpression variation between the two parental genotypes, which may explain the contrasting growth habi

292 opulation grown in multiple environments and genotyped with 2.5 million single-nucleotide polymorphi

293 All family members were genotyped with markers spaced by every 10 cM and a model

294 Genotypes with and without aerial buds were identified i

295 There were no significant interactions of genotypes with calcium supplementation.

296 cision intervention for patients of specific genotypes with IBD.

297 es enable single-molecule co-localization of genotypes with phenotypes, are well suited for multiplex

298 urther propose a strategy for integrating IG genotyping with functional Ab profiling data as a means

299 showed high conservation across the Arachis genotypes, with eight haplotypes identified.

300 A significant CYP2A6 genotype x smoking effect was found in the dorsal anteri