ライフサイエンスコーパス: genotypic

1 ing Mendelian error rates as an indicator of genotypic accuracy.

2 Genotypic algorithms overestimated resistance to etravir

3 However, genotypic algorithms predicting resistance are mainly ba

4 To investigate phenotypic and genotypic alterations before and after bone metastasis,

5 ductive state and choline intake, with fewer genotypic alterations observed among pregnant women.

6 Phenotypic and genotypic analyses demonstrated that these hESCs/hiPSCs

7 Rued et al. combine phenotypic and genotypic analyses of mutant strains that suggest discre

8 Genotypic analysis in 386 participants revealed that 323

9 In CMV-negative recipients, genotypic analysis of KIR repertoire and HLA ligands doe

10 pism can be assessed by either phenotypic or genotypic analysis, the latter using bioinformatics algo

11 Metabolomics analysis showed that genotypic and dietary effects on white adipose tissue re

12 cs techniques have generated vast amounts of genotypic and molecular phenotypic data.

13 The best predictability was observed when genotypic and pedigree data were included in the models

14 Genotypic and phenotypic analyses showed no difference b

15 The patient's HIV was CCR5-tropic by genotypic and phenotypic analyses.

16 We report here the genotypic and phenotypic analysis of viruses obtained at

17 ntial to understand the relationship between genotypic and phenotypic change.

18 Here we report the genotypic and phenotypic characterization of 15 viral br

19 rting enrichment followed by high-throughput genotypic and phenotypic clonal screening strategies to

20 We retrospectively analysed genotypic and phenotypic data (age at symptom onset, ini

21 and may become useful for efforts to combine genotypic and phenotypic data for risk prediction and to

22 We used genotypic and phenotypic data from 10 760 individuals ag

23 We included genotypic and phenotypic data from 295 Australian famili

24 Global sharing of this more accurate genotypic and phenotypic data will accelerate the determ

25 policy covers both human and model-organism genotypic and phenotypic data, and strives to balance ra

26 In the postgenomic era, the genotypic and phenotypic differences between the AAT-rel

27 same parental C57BL/6 strain, there are key genotypic and phenotypic differences between these subst

28 ons of changes in multiplex we generate rich genotypic and phenotypic diversity and characterize clon

29 yletic lineage can still exhibit significant genotypic and phenotypic diversity.

30 heir clinicopathological parameters, but how genotypic and phenotypic heterogeneity are interconnecte

31 Our findings expand the genotypic and phenotypic heterogeneity of congenital acr

32 isorders of keratinization (DOK) show marked genotypic and phenotypic heterogeneity.

33 a neurodegenerative disease characterized by genotypic and phenotypic heterogeneity.

34 This multicenter study assembled genome-wide genotypic and phenotypic measures from 14 data sets of t

35 e introduced, and reveal limitations of both genotypic and phenotypic methods.

36 gthening RNA folding simultaneously curtails genotypic and phenotypic mutations.

37 Genotypic and phenotypic screening of C. difficile isola

38 To explore the distinct genotypic and phenotypic states of melanoma tumors, we a

39 Genotypic and phenotypic studies should be prespecified

40 tegies after first-line failure, we compared genotypic and phenotypic susceptibility of subtype C hum

41 al evolution, and we assessed the associated genotypic and phenotypic traits.

42 ation has played a pervasive role in shaping genotypic and phenotypic variation in modern humans.

43 Finding causal relationships between genotypic and phenotypic variation is a key focus of evo

44 echanisms including physiological, physical, genotypic and phenotypic variations.

45 Individual strains exhibit genotypic and potential phenotypic variation via HFMs, d

46 We studied 2070 Latino children (8-21y) with genotypic and pulmonary function data from the GALA II c

47 growth rate FVT and uncovered differences in genotypic and QTL correlations involving FVT vs STPs.

48 aneuploidy is not general but contingent on genotypic and/or developmental context.

49 Phenotypic, genotypic, and antimicrobial characteristics of six phen

50 borne transcripts, and thus explore a larger genotypic--and so phenotypic--space.

51 phoramidate nucleotide 16, as a nontoxic pan-genotypic anti-HCV agent.

52 LA Health introduced a rapid gyrase A (gyrA) genotypic assay for prediction of Neisseria gonorrhoeae

53 esting is slow and expensive, and commercial genotypic assays screen only common resistance-determini

54 d onset of diseases, depending on individual genotypic background and types of subsequent exposures.

55 the individual rather than the individual's genotypic background.

56 erogeneity appearing a greater confound than genotypic background.

57 Coinfecting isolate pairs had different genotypic backgrounds.

58 We used clinical and genotypic case definitions to calculate the proportion o

59 oaches have proven to be helpful for finding genotypic causes of diseases, classifying disease subtyp

60 d therapeutics will require harnessing pheno-genotypic cell-level data quantitatively and predictivel

61 number of novel phenotypes reachable through genotypic change is highest for organisms with simple ph

62 On the one hand, genotypic change is more likely to yield novel phenotype

63 The likely common cause is robustness to genotypic change.

64 lopment of a comprehensive theory that links genotypic changes to their phenotypic effects.

65 le on new carbon sources--through one or few genotypic changes.

66 Phenotypic and genotypic characteristics in these patients from birth o

67 ted the impact of sarA on the phenotypic and genotypic characteristics of oxacillin resistance both i

68 011 TIV and in the context of phenotypic and genotypic characterization of circulating viruses.

69 Collectively, the pheno- and genotypic characterization of the glucose starvation ind

70 in all cases, as evidenced by comparing the genotypic characterizations of biological replicates.

71 cally monophyletic and show strongly bimodal genotypic clustering and no evidence of contemporary mig

72 No genotypic clustering by geographical origin or isolation

73 Spatial and genotypic clustering of M. tuberculosis isolates reveale

74 Both SNPs and GEMs identify six genotypic clusters in the collection.

75 The pan-genotypic combination of daclatasvir, sofosbuvir, and ri

76 nal manifestation of infertility in specific genotypic combinations.

77 For HIV-negative couples, genotypic concordance was 30% at baseline (n = 219/725)

78 o the level of single-cells for thousands of genotypic conditions.

79 symptoms late in life, closely mimicking the genotypic context and disease progression in human HD.

80 Paradoxically, the effects of genotypic context in individuals and populations are dis

81 f genotype on phenotype therefore depends on genotypic context through gene interactions known as epi

82 to result in underestimating the effects of genotypic context.

83 speed of over 1000 times faster to calculate genotypic correlation.

84 rces using subjects' clinical phenotypic and genotypic criteria.

85 ata, genomic marker sets of high-dimensional genotypic data and sparse functional variants are quite

86 ing the same immortalized F2 rice population genotypic data examined in a previous study, the PEPIS r

87 This study used genotypic data from 4,294 cases and 10,340 controls obta

88 Genotypic data from 491,265 variants were analyzed for a

89 Using genotypic data from a GWAS of the Study of Addiction: Ge

90 It means that genotypic data from genotyping technologies that provide

91 Genome-wide genotypic data of 2576 families from the Simons Simplex

92 ew high-density rice array, the accompanying genotypic data set, and an expanded diversity panel for

93 r of methods integrate patient phenotype and genotypic data to prioritise variants as potentially cau

94 Here, we use genotypic data to study range-wide patterns of genetic a

95 Genotypic data were combined with phenotypic AMR informa

96 The integration of genotypic data, pedigree records and shell formation mod

97 ted selection depends on good phenotypic and genotypic data.

98 sts were applied to the 1000 Genomes imputed genotypic data.

99 f interconnectable phenotypic, molecular and genotypic data.

100 gorization of patients with a phenotypic and genotypic descriptor that will clarify etiology, provide

101 Several groups have proposed that genotypic determinants in gag and the gp41 cytoplasmic d

102 itive-selection analyses to characterize the genotypic determinants of resistance and found that (i)

103 ve B. napus accessions that otherwise show a genotypic difference in the progression of homologous re

104 ignaling dysregulate FAAH activity, and this genotypic difference is normalized with pharmacological

105 Genotypic differences between the twin pairs-such as cop

106 Substantial efforts to identify genotypic differences explaining this differential susce

107 t to highlight metabolic control, we explore genotypic differences in carbon partitioning for in vitr

108 gical reduction of MOR availability unmasked genotypic differences in fentanyl sensitivity.

109 s and gene-families were mostly related with genotypic differences in interactive responses to this m

110 There were no consistent genotypic differences in two-bottle choice chronic ethan

111 improve understanding of the phenotypic and genotypic differences that exist between patients and th

112 studies on GI.1 and GI.2 NoVs, we show that genotypic differences translate to extensive structural

113 Additionally, phenotypic and genotypic differences were examined in the single and do

114 c CLN3 disease, which may be associated with genotypic differences.

115 VHT and LVNC likely represent a continuum of genotypic disease with differences in severity and varia

116 PD patients, and was closely associated with genotypic distribution of rs11931074 and rs894278 in PD,

117 ntitative molecular trait despite underlying genotypic divergence.

118 ion by 13.5%, maintained 10.4% greater aphid genotypic diversity and 5.6% higher genotypic richness.

119 her of these opposing aspects of sex require genotypic diversity in the population.

120 However, the impacts of intraspecific genotypic diversity in these studies are unknown, despit

121 This study aimed to quantify how the genotypic diversity of root tip geometry and root diamet

122 For evaluating the genotypic diversity, pulsed-field gel electrophoresis (P

123 Our results show that sociality maximizes genotypic diversity, which contradicts the belief that s

124 social antagonism that should result in low genotypic diversity, which is inconsistent with observat

125 Social structure generates an excess of genotypic diversity.

126 , they can sometimes instead result in mtDNA genotypic drift and reversion to the original genotype.

127 I) regimen in Africa and Asia, comparing the genotypic drug resistance and phenotypic profile from th

128 icated methods for monitoring phenotypic and genotypic dynamics in bacteria causing infectious diseas

129 was negatively associated with strong cross-genotypic E1E2 binding (P= 0.03).

130 to their underlying components, constitutive genotypic effect (G), G x D, G x H, and G x H x D, and w

131 , CpG sites, and SNPs by jointly testing for genotypic effect and higher order interaction effects be

132 ence of Na+/H+ exchange activity, the SLC4A7 genotypic effect on net base uptake and steady-state pHi

133 A genotypic effect on response to TNFalpha stimuli was det

134 alf due to NDH mutation in maize although no genotypic effect was evident at very low CO2 levels.

135 The DAPN-PDs were pan-genotypic, effective against various HCV resistant mutan

136 When adjusted for genotypic effects the overall model was validated, with

137 , education and heart disease show declining genotypic effects.

138 w hepatitis C virus (HCV) therapies with pan-genotypic efficacy are needed.

139 nfected patients were consistent with 80-90% genotypic evaluations, while phenotypic assessments rect

140 Overall, phenotypic and genotypic factors explained only a modest amount of vari

141 adaptive steps while delaying commitment to genotypic fate, hindering our ability to predict or cont

142 nd 1 patient was infected with a DLST having genotypic fluoroquinolone resistance.

143 ificant difference was observed in allele or genotypic frequencies of these SNPs between Chinese RB p

144 Using a comprehensive evaluation of genotypic (gene comparisons and multilocus sequence typi

145 It was discovered that compound 38 was a pan-genotypic HCV inhibitor, with an EC50 range of 1.7-19.3

146 me is frequently the result of both parties' genotypic identities.

147 st between neuronal activity, structure, and genotypic identity.

148 ces in these hydraulic traits appear largely genotypic in origin rather than environmentally plastic.

149 The finding of a genotypic influence on SLC4A7 expression and pHi regulat

150 etics that can obscure the identification of genotypic influences on disorder.

151 This study uses genotypic information as a causal anchor to help deciphe

152 orld's largest repository for phenotypic and genotypic information for individuals of European ancest

153 ld's largest repositories for phenotypic and genotypic information in individuals of European ancestr

154 Although there is no explicit genotypic information in phenotype data, adversaries can

155 generation technologies that seek to provide genotypic information in spite of great proportions of m

156 ing discipline of radiogenomics, which links genotypic information to phenotypic disease manifestatio

157 in development for even species with minimal genotypic information.

158 AS) approach, using automated screening with genotypic instruments to screen for causal associations

159 However, plant-bacteria genotypic interactions can lead to wide variation in nit

160 experimental test of whether four different genotypic lines, some are novel with no previous field t

161 udies are an invaluable tool for identifying genotypic loci linked with agriculturally important trai

162 nitalium were infected with DLSTs possessing genotypic macrolide resistance and 1 patient was infecte

163 e innovations have also been integrated with genotypic mapping of neurodevelopmental disorders, formi

164 Further experimental phenotypic-to-genotypic mapping that we conducted for knock-out mutant

165 rica and indicate the utility of msp1aS as a genotypic marker for A. marginale subsp. centrale strain

166 We assessed phenotypic and genotypic markers of drug resistance in parasite isolate

167 es from the same vineyard, thus highlighting genotypic markers.

168 ociated with clinical presentations or other genotypic markers.

169 The genotypic matrix captured the highest amount of genetic

170 apsule operon; of the isolates identified by genotypic methods, </=43% were serogroupable with any of

171 y 47% of carriage isolates were groupable by genotypic methods, due to mutations within the capsule o

172 ull (full interaction model with additive or genotypic mode) and SNPassoc in detecting interactions.

173 e, and overdominant trait model as well as a genotypic model with two degree-of-freedom (2-df) that a

174 at 7 951 614 (additive model) and 4 669 537 (genotypic model) loci.

175 There was no genotypic mutation detected.

176 es a useful tool for interpreting meaningful genotypic mutations and guiding tailored antiviral treat

177 with a lower incidence of weakly deleterious genotypic mutations.

178 Associations between genotypic networks and clinical syndromes were complex,

179 ders caused by a moderate number of separate genotypic networks associated with several distinct clin

180 Third, they identified genotypic networks composed of SNP sets sharing SNPs or

181 p of heritable disorders caused by different genotypic networks that cause distinct clinical syndrome

182 These disjoint genotypic networks were associated with distinct gene pr

183 60-mg once-daily dosage of daclatasvir (pan-genotypic NS5A inhibitor) in combination with sofosbuvir

184 Pan-genotypic nucleoside HCV inhibitors display a high genet

185 s of C. glabrata isolates, which may lead to genotypic or phenotypic antifungal testing in clinical p

186 utomatically designs oligos based on desired genotypic or phenotypic changes defined by the user, whi

187 ovides information that is not confounded by genotypic or phenotypic heterogeneity of bulk samples.

188 Finally, we compared phenotypic versus genotypic ORs to estimate whether apolipoprotein(a) isof

189 Data indicate significant phenotypic and genotypic overlap, plus a common pathogenesis, between t

190 onder phenotype at the allelic (P<0.035) and genotypic (P<0.031) level: rs3766031 (ATPIB1), rs5443 (G

191 w that, while height and BMI show increasing genotypic penetrance over the course of 20(th) Century,

192 Meanwhile, we find genotypic penetrance to be historically stable with resp

193 o achieve this goal, globally representative genotypic, phenotypic, and clinical data are needed in a

194 Surveillance linking genotypic, phenotypic, and epidemiologic measures of vac

195 e determined the sensitization mechanism via genotypic, phenotypic, signaling, and binding measuremen

196 Scrutiny of the genotypic-phenotypic relationship of each detected varia

197 seudotyped virus to explore the link between genotypic predictions and phenotypic assessment of corec

198 A small number of discrepancies between the genotypic predictions and phenotypic DST results are dis

199 The genotypic predictions were then compared to phenotypic r

200 imal donor selection based on phenotypic and genotypic properties, by adoptive transfer of NK cells w

201 Based on physiological, biochemical and genotypic properties, the strain was considered to repre

202 y impact survival, hatch success, growth, or genotypic ratios.

203 OST, n = 51) evaluating the once-daily, pan-genotypic regimen of sofosbuvir/velpatasvir for hepatiti

204 A safe, simple, effective, and pan-genotypic regimen to treat hepatitis C virus (HCV) infec

205 The impact of RBV-free pan-genotypic regimen with SOF and velpatasvir (SOF/VEL) on

206 cing of nosocomial MDRPa strains to evaluate genotypic relationships between isolates.

207 tion (FDA)-approved antiviral drug for which genotypic resistance analyses were based almost entirely

208 Genotypic resistance analyses were conducted using Sange

209 hile phenotypic assessments rectified 10-20% genotypic resistance calls.

210 be, while 3 patients demonstrated additional genotypic resistance determinants.

211 Lack of evidence for genotypic resistance during prophylaxis suggests that fi

212 Genotypic resistance for the entire cohort at baseline w

213 ation published since 2010 on phenotypic and genotypic resistance mechanisms in C. difficile and addr

214 We tested genotypic resistance on stored baseline samples in patie

215 Available integrase genotypic resistance patterns were Y143C/G/H/R (n = 5),

216 Using BMD as the gold standard, our genotypic resistance prediction approach had a significa

217 ach to ARV therapy, a reliable point-of-care genotypic resistance test could identify which patients

218 sults of HCV serologic tests and with an HIV genotypic resistance test performed during early HIV inf

219 as the presence of >/=1 major mutation in a genotypic resistance test.

220 uated reliability and clinical usefulness of genotypic resistance testing (GRT) in patients for whom

221 h, and public health laboratories performing genotypic resistance testing by sequencing HIV-1 PR, RT,

222 tic assays for use in regions where standard genotypic resistance testing is not affordable.

223 INTERPRETATION: Genotypic resistance testing might not accurately predic

224 A survey was performed on genotypic resistance testing results acquired during rou

225 sents a challenge to laboratories performing genotypic resistance testing.

226 esults of all clinically indicated integrase genotypic resistance tests (GRTs) performed at a US nati

227 ntly infected, treatment-naive patients with genotypic resistance tests performed </= 1 year after in

228 Moreover, genotypic resistance to clarithromycin can be predicted

229 oncordant for first-line drugs, estimates of genotypic resistance to etravirine and rilpivirine may m

230 We evaluated the genotypic results as predictors of resistance or suscept

231 ease in competition between bacteria at high genotypic richness and the potential loss of fungal bioc

232 icrocosms, and show that increased bacterial genotypic richness escalates bacterial antagonism and de

233 er aphid genotypic diversity and 5.6% higher genotypic richness.

234 medicine that enhances inference from static genotypic risk assessment.

235 s, to dissect the context-specific nature of genotypic risks, to prioritize variants in genome-wide a

236 s-to-length ratio was correlated with higher genotypic root elongation rate, whereas root diameter wa

237 te, whereas root diameter was not related to genotypic root elongation.

238 nce mutations, providing useful insights for genotypic screening and to guide drug development.

239 co-housed littermates followed by 18 days of genotypic segregation, we examined the influence of AHR

240 species diversity in Ahr(-/-) mice following genotypic segregation.

241 kground antiretroviral regimens conferring a genotypic sensitivity score </=2 in 10 patients included

242 plasma HIV-1 were used to generate separate genotypic sensitivity scores (GSS) using the HIVdb, ANRS

243 Baseline viral isolates were assigned genotypic sensitivity scores (GSSs) by use of the Stanfo

244 cing (WGS) to investigate the phenotypic and genotypic serotype identifications.

245 esults to those of a virtual population with genotypic sex determination (GSD) and fixed sex ratios.

246 Our results provide crucial evidence for genotypic sex determination facilitating land-water tran

247 ls (0 to 4 days post fertilization) of known genotypic sex to fluctuations of Delta4 degrees C over 1

248 , if loners are accounted for, then apparent genotypic skew in the spores of chimeras could simply be

249 The phenotypic and genotypic spectra of ATP1A3 mutations have considerably

250 Our findings expand the genotypic spectrum of BSI and the understanding of tempe

251 To expand the genotypic spectrum of BSI, identifying novel TGM1 mutati

252 may allow description of the phenotypic and genotypic spectrum of disease associated with GNB3 retin

253 nition that tumors are populated by distinct genotypic subgroups that drive tumor development and pro

254 n brincidofovir-treated subjects; identified genotypic substitutions did not confer resistance to cyt

255 DGFRA mutations, optimal management of other genotypic subtypes remains unclear.

256 Inconclusive genotypic susceptibility results for both rifampin and i

257 We developed an easy-to-perform genotypic TaqMan array card (TAC) to identify S. pneumon

258 he new data strengthen the interpretation of genotypic testing for cytomegalovirus drug resistance.

259 A database of phenotypic and genotypic testing results, especially where prospectivel

260 iscrepant results between the phenotypic and genotypic tests were attributed to insertions/deletions

261 f carcinogenic chemicals, and monitoring the genotypic toxicology of environments.

262 lts support established theories but unknown genotypic traits explained much of the variation in defe

263 the improved development of vaccines and pan-genotypic treatments, which require the consideration of

264 erefore developed PhenoSeq, a suite of HIV-1 genotypic tropism assays that are highly sensitive and s

265 1 therapy regimens is that the pre-treatment genotypic "tropism tests" to determine virus susceptibil

266 on based on the partition of a multi-allelic genotypic value into additive and dominance values.

267 formulations for partitioning multi-allelic genotypic values and provides a haplotype method based o

268 rately predicting genomic breeding and total genotypic values as well as for estimating additive and

269 ion of genomic breeding as well as the total genotypic values of individuals in all four scenarios (t

270 of breeding values, dominance deviations and genotypic values, and for genomic estimation of additive

271 ion methods in a dataset missing 20 % of the genotypic values.

272 ronment (GE) interaction was used to predict genotypic values; cross-validation methods were applied

273 Genotypic variability based genome-wide association stud

274 We report a genotypic variability-based genome-wide association stud

275 increased by epistasis, for a given initial genotypic variance.

276 ulation is proportional to the initial total genotypic variance.

277 oportion of variance that is attributable to genotypic variance.

278 ounder HIV-1 subtype A, B, C, or D Envs with genotypic variants at residue 375 were constructed and a

279 revealed 12 distinct hla genotypes, and all genotypic variants were susceptible to a neutralizing mo

280 molecularly tagged viral stock containing 10 genotypic variants, at a dose calculated to transmit 12

281 during neurogenesis is a potential source of genotypic variation among neurons.

282 The SET and SDW exhibited appreciable genotypic variation among wheat genotypes at the anthesi

283 However, the genotypic variation and the genomic regions governing sp

284 Genotypic variation for PhiPSII is shown by calculating

285 ession of EXPA4 and EXPA7 was related to the genotypic variation in LER of two cultivars.

286 vides a strong conceptual basis for modeling genotypic variation in response to elevated [CO2 ].

287 Genotypic variation in the irradiance at which energy fl

288 Genotypic variation in the islands is very low and clona

289 We investigated genotypic variation in the production of SET and its rel

290 pression plays a central role in translating genotypic variation into phenotypic variation.

291 ncies within populations and the fixation of genotypic variation into traits that define species or e

292 nutrient concentrations, we investigated the genotypic variation of the concentrations of individual

293 n the genomes which can be used to associate genotypic variation to the phenotype.

294 and seasonal variation indicative of natural genotypic variation.

295 utrophil reactivity is influenced by FCGR2/3 genotypic variation.

296 of how antibodies block HBGA binding and how genotypic variations affect such blockade is lacking.

297 , from crystallographic studies, we show how genotypic variations configure a novel binding site in t

298 However, it is unclear whether genotypic variations in host organisms influence the mic

299 the antigenic site in the P domain shows how genotypic variations might allow escape from antibody ne

300 The general goal of GWAS is to link genotypic variations to corresponding differences in phe