ライフサイエンスコーパス: geranyl

1 abeled with 3-azido-2-methyl-5-methoxy-[3H]6-geranyl-1,4-benzoquinone ([3H]azido-Q) followed by SDS-p

2 inity label 3-[3H]azido-2-methyl-5-methoxy-6-geranyl-1,4-benzoquinone (azido-Q), a substrate analogue

3 lanone-B, as well as to the general odorants geranyl acetate and hexanol.

4 Geraniol, geranial, and geranyl acetate were the most abundant compounds.

5 s from surfaces (stearic acid) and from air (geranyl acetate) than groomed antennae.

6 ly-reported aroma active rice volatiles were geranyl acetate, beta-damascone, beta-damascenone, and a

7 ation of the appropriate anilines with 8-oxo-geranyl acetate, followed by ester hydrolysis, chlorinat

8 For the cyclization of geranyl acetate, it was found that the cleavage of the l

9 synthetic intermediate readily prepared from geranyl acetate.

10 tion of Azocompost alone increased levels of geranyl acetate.

11 h the geranyl-diphosphate pathway (neryl and geranyl acetates) and some terpenoids were found in the

12 ir high OAVs, cis-linalool oxide (furanoid), geranyl acetone, and cinnamyl acetate were identified as

13 -jasmone, 2-acetylpyrrole, farnesyl acetone, geranyl acetone, cadinol, cubenol and dihydroactinidioli

14 Wild type Nm23-H1 had higher geranyl and farnesyl pyrophosphate kinase activities tha

15 The phosphorylation of geranyl and farnesyl pyrophosphates by Nm23 proteins pro

16 report that Nm23 proteins can phosphorylate geranyl and farnesyl pyrophosphates to give triphosphate

17 at VvGT7 may contribute to the production of geranyl and neryl glucoside during grape ripening.

18 placement by the less hydrophobic isoprenoid geranyl causes severely delayed oocyte activation.

19 d stereoselectively in just three steps from geranyl chloride or neryl chloride, providing a short an

20 ferences in the structures of functionalized geranyl chlorides can significantly impact their abiliti

21 Geranyl-CoA carboxylase (GCC) is essential for the growt

22 ne in MCC, which blocks access by the larger geranyl-CoA substrate.

23 that CoQ analogs with long decyl (CoQ(D)) or geranyl (CoQ(2)) tails partition into detergent micelles

24 ated as a possible C-methyltransferase, with geranyl diphosphate (1) and S-adenosylmethionine gave th

25 e the corresponding chlorinated analogues of geranyl diphosphate (3-ClGPP) and farnesyl diphosphate (

26 antly to beta-cubebene, while Mg17 converted geranyl diphosphate (C(5)) to alpha-terpineol.

27 in plants typically proceeds through either geranyl diphosphate (C10) or trans-farnesyl diphosphate

28 noid coupling reactions to give a mixture of geranyl diphosphate (chain elongation), chrysanthemyl di

29 phosphate synthase 1 (PcIDS1) yields 96% C10-geranyl diphosphate (GDP) and only 4% C15-farnesyl dipho

30 nd dimethylallyl diphosphate (DMAPP) to form geranyl diphosphate (GPP) and between IPP and GPP to giv

31 S1 catalyzing the irreversible conversion of geranyl diphosphate (GPP) to geraniol.

32 ed with dimethylallyl diphosphate (DMAPP) or geranyl diphosphate (GPP) to give the corresponding chlo

33 MoeN5 catalyzes the reaction of geranyl diphosphate (GPP) with the cis-farnesyl group in

34 is hypothesized to originate from 10-carbon geranyl diphosphate (GPP), 15-carbon farnesyl diphosphat

35 te (IPP), dimethylallyl diphosphate (DMAPP), geranyl diphosphate (GPP), farnesyl diphosphate (FPP), a

36 ere the C(10) product of the first addition, geranyl diphosphate (GPP), is the substrate for the seco

37 wers include three monoterpenes derived from geranyl diphosphate (GPP), myrcene, (E)-beta-ocimene and

38 (Humulus lupulus L.) trichomes, derives from geranyl diphosphate (GPP), the common precursor of monot

39 Geranyl diphosphate (GPP), the precursor of many monoter

40 Geranyl diphosphate (GPP), the precursor of most monoter

41 modifies an acyclic isoprenoid diphosphate, geranyl diphosphate (GPP), to yield a noncanonical acycl

42 imethylallyl diphosphate (DMAPP) and then to geranyl diphosphate (GPP).

43 th dimethylallyl diphosphate (DMAPP, C5) and geranyl diphosphate (GPP, C10) to give (E,E)-FPP (C15).

44 ted L. x intermedia CINS (LiCINS), converted geranyl diphosphate (the linear monoterpene precursor) p

45 nzyme activity level (7-fold), and in planta geranyl diphosphate and geranylgeranyl diphosphate level

46 e overexpressed a bifunctional spruce IDS, a geranyl diphosphate and geranylgeranyl diphosphate synth

47 values of 21 and 51 microM were obtained for geranyl diphosphate and Mn2+, respectively.

48 Incubation of geranyl diphosphate and S-adenosylmethionine with a mixt

49 zyme was functionally expressed and produced geranyl diphosphate as its major product.

50 functional hybrid heterodimer that generated geranyl diphosphate as product in each case.

51 to all known monoterpene cyclases, which use geranyl diphosphate as substrate and invoke a cationic i

52 on in Escherichia coli and enzyme assay with geranyl diphosphate as substrate, subsequent analysis of

53 icate that, contrary to the textbook view of geranyl diphosphate as the "universal" substrate of mono

54 he monoterpene bornyl diphosphate (BPP) from geranyl diphosphate by BPP synthase using state of the a

55 Geranyl diphosphate C-methyltransferase (GPPMT) from Str

56 lly synthesized as stable analogs of omega,E-geranyl diphosphate in which the labile diphosphate moie

57 enchol synthase, plant cyclases that convert geranyl diphosphate into products with closely related b

58 The data from both organisms suggest that geranyl diphosphate is the allylic substrate for two dis

59 Geranyl diphosphate is the precursor of monoterpenes, a

60 , except for a relatively low K(m) value for geranyl diphosphate of 0.2 microm.

61 dition of isopentenyl diphosphate to omega,E-geranyl diphosphate or omega,Z-neryl diphosphate yieldin

62 FDS-1 prefers geranyl diphosphate over dimethylallyl diphosphate as an

63 t cells overexpressing Rv1086 incubated with geranyl diphosphate showed a 5-fold increase of [(14)C]i

64 Geranyl diphosphate synthase (GPPS) catalyzes the conden

65 myrcene, in transgenic tobacco by elevating geranyl diphosphate synthase (GPS) activity.

66 phate synthase (SlDXS), Arabidopsis thaliana geranyl diphosphate synthase 1 (AtGPS) and Mentha x pipe

67 The relative levels of geranyl diphosphate synthase and farnesyl diphosphate sy

68 the hybrid possesses characteristics of both geranyl diphosphate synthase and geranylgeranyl diphosph

69 Geranyl diphosphate synthase belongs to a subgroup of pr

70 synthases; yet it is absolutely required for geranyl diphosphate synthase catalysis.

71 diphosphate synthase, which are homodimers, geranyl diphosphate synthase from Mentha is a heterotetr

72 phosphate pathway were overexpressed, and a geranyl diphosphate synthase from the plant Abies grandi

73 nd recombinant enzymes, thus confirming that geranyl diphosphate synthase is a heterodimer.

74 Immunogold labeling of geranyl diphosphate synthase occurred within secretory c

75 ate synthase 1 (AtGPS) and Mentha x piperita geranyl diphosphate synthase small subunit (MpGPS.SSU) o

76 These results indicate that the geranyl diphosphate synthase small subunit is capable of

77 expression in Escherichia coli of the Mentha geranyl diphosphate synthase small subunit with the phyl

78 l subunits of peppermint (Mentha x piperita) geranyl diphosphate synthase, spearmint (Mentha spicata)

79 Geranyl diphosphate synthase, which catalyzes the conden

80 sion of the two together produced functional geranyl diphosphate synthase.

81 proceed via an RR-dependent isomerization of geranyl diphosphate to 3S-linalyl diphosphate, as shown

82 terpene cyclase limonene synthase transforms geranyl diphosphate to a monocyclic olefin and constitut

83 ersion of the ubiquitous terpenoid precursor geranyl diphosphate to the iridoid loganic acid.

84 te; however, one truncated protein converted geranyl diphosphate to the monoterpene limonene.

85 r isopentenyl diphosphate, 38 micrometer for geranyl diphosphate, and 16 micrometer for neryl diphosp

86 mation of the prenyl diphosphate precursors, geranyl diphosphate, farnesyl diphosphate, and geranylge

87 se in that it adds only one isoprene unit to geranyl diphosphate, generating the 15-carbon product (E

88 , myrcene and (E)-beta-ocimene, derived from geranyl diphosphate, in addition to a major phenylpropan

89 catalyzed the formation of 18O-geraniol from geranyl diphosphate, indicating that the reaction mechan

90 the coupled isomerization and cyclization of geranyl diphosphate, is reported at 2.7-A; resolution in

91 s the addition of isopentenyl diphosphate to geranyl diphosphate, neryl diphosphate, omega,E,E-farnes

92 terminal domain catalyzes the cyclization of geranyl diphosphate, orienting and stabilizing multiple

93 l diphosphate and isopentenyl diphosphate to geranyl diphosphate, the key precursor of monoterpene bi

94 ncapable of converting the natural substrate geranyl diphosphate, via the enzymatically formed tertia

95 ase (GES) activity, generating geraniol from geranyl diphosphate, was shown to be localized exclusive

96 additional product, the regular monoterpene geranyl diphosphate, when incubated with isopentenyl dip

97 e formation of 10 volatile monoterpenes from geranyl diphosphate, with 1,8-cineole predominating.

98 e, Rv1086, adds one isoprene unit to omega,E-geranyl diphosphate.

99 , respectively, as their major products from geranyl diphosphate.

100 carboxamide intermediate 2 at carbon 6 with geranyl diphosphate.

101 e (C(50)) from isopentenyl diphosphate and E-geranyl diphosphate.

102 hosphate and isopentenyl diphosphate to form geranyl diphosphate.

103 ation of both geraniol and (R)-linalool from geranyl diphosphate.

104 for activity and produces only geraniol from geranyl diphosphate.

105 r content of some compounds related with the geranyl-diphosphate pathway (neryl and geranyl acetates)

106 for rat farnesyl diphosphate (FPP) synthase (geranyl-diphosphate:isopentenyl-diphosphate geranyltrans

107 Regiospecifically labeled geranyl diphosphates ((2E,6E)-[1,1,8,8,8-(2)H(5)]- and (

108 ophylls-e, including a previously unreported geranyl ester of 4-i-butyl bacteriochlorophyll-e.

109 ctivity in Escherichia coli by using labeled geranyl, farnesyl, and geranylgeranyl diphosphates as su

110 the diphosphate derivatives of isopentenyl, geranyl, farnesyl, geranylgeranyl, and presqualene.

111 yl geranyl transferase I, and the effects of geranyl geranyl transferase I inhibitors on cell cycle,

112 s by the closely related prenyl transferase, geranyl geranyl transferase I, and the effects of gerany

113 pt analysis suggested that the heterodimeric geranyl(geranyl)diphosphate synthase [G(G)PPS] is involv

114 Furthermore, our data suggest that double geranyl-geranyl groups are required for Rab proteins to

115 t is completely different from the G protein-geranyl-geranyl interaction face of the Ig-like domain o

116 ects the time-course of translocation of the geranyl-geranyl lipid tail of Cdc42 from the outer leafl

117 yme A) and farnesyl-pyrophosphate but not by geranyl-geranylpyrophosphate or cholesterol.

118 ce with Rac3 activity, for example, by using geranyl-geranyltransferase inhibitors, may provide a pos

119 Gewurztraminer glycosides, geranyl glucoside and guaiacyl glucoside were investigat

120 concentration, Gewurztraminer glycosides and geranyl glucoside gave significant fruity flavour, altho

121 sed aromatic core with an attached 10-carbon geranyl group derived from isoprenoid (terpene) metaboli

122 es to explore the structural features of the geranyl group in the context of A-form RNA and its effec

123 In vivo, Orf2 attaches a geranyl group to a 1,3,6,8-tetrahydroxynaphthalene-deriv

124 and precisely aligns the double bond of the geranyl group with respect to the FAD cofactor, thus pro

125 (S)-Dimethylallyl (DMASPP), (S)-geranyl (GSPP), (S)-farnesyl (FSPP), and (S)-geranylgera

126 onger (C20) isoprenols as well as N-acetyl-S-geranyl-L-cysteine (C10) did not inhibit the response to

127 itor of methylation, but not AGC (N-acetyl-S-geranyl-L-cysteine), an inactive analog of AFC.

128 tion, acting at least partly via blockade of geranyl lipid production downstream of HMG-CoA reductase

129 The method was extended with geranyl migration in eight-step total syntheses of heric

130 cal, signal peptide-dependent pathway, but a geranyl-modified attractant would require an alternative

131 s the sole enzyme required for cyclizing the geranyl moiety.

132 synthesized terpenyl-ss-D-glycopyranosides (geranyl, neryl, citronellyl, myrtenyl) were subjected to

133 n the reaction mixtures of L-tryptophan with geranyl or farnesyl diphosphate.

134 contain 5-carbon (dimethylallyl), 10-carbon (geranyl) or 15-carbon (farnesyl) isoprenoid chains posse

135 hains or metabolites via the condensation of geranyl- or isopentenyl-diphosphate moieties by geranylt

136 chain was synthesized through coupling with geranyl phenyl sulfide and Bouveault-Blanc reduction.

137 butyl phosphate, 3-buten-1-yl phosphate, and geranyl phosphate, were evaluated as alternative substra

138 lthough the catalytic efficiency was low for geranyl phosphate.

139 c analyses show that pyrophosphates 1a-e and geranyl pyrophosphate (GPP) transfer with a lower effici

140 s reveal that inhibition is competitive with geranyl pyrophosphate and is of a slow, tight binding ch

141 These agents bind to the dimethylallyl/geranyl pyrophosphate ligand pocket and induce a conform

142 hapalindoles from cis-indole isonitrile and geranyl pyrophosphate through a presumed biosynthetic Co

143 ting for the route from phosphomevalonate to geranyl pyrophosphate, are missing, as are the enzymes f

144 he tested metabolites, including mevalonate, geranyl pyrophosphate, farnesyl pyrophosphate, and ubiqu

145 E2 formed the linear monterpene myrcene from geranyl pyrophosphate, whereas hop SESQUITERPENE SYNTHAS

146 osphate with dimethylallyl pyrophosphate and geranyl pyrophosphate.

147 osphate with dimethylallyl pyrophosphate and geranyl pyrophosphate.

148 ternary complex of bacitracin A, zinc, and a geranyl-pyrophosphate ligand at a resolution of 1.1 A.

149 n complex with GPP or the substrate analogue geranyl S-thiolodiphosphate (GSPP) along with S-adenosyl

150 termined in complex with substrate analogues geranyl-S-thiolodiphosphate and 2-fluorogeranyl diphosph

151 In one, the geranyl side chain binds to either S1 or S2 and the adam

152 Crystal structures reveal the geranyl side chain of amorfrutin B as the cause of its p

153 activity in vitro established that VrtC is a geranyl transferase that catalyzes a regiospecific Fried