ライフサイエンスコーパス: geranyl diphosphate

1 carboxamide intermediate 2 at carbon 6 with geranyl diphosphate.

2 e (C(50)) from isopentenyl diphosphate and E-geranyl diphosphate.

3 hosphate and isopentenyl diphosphate to form geranyl diphosphate.

4 ation of both geraniol and (R)-linalool from geranyl diphosphate.

5 for activity and produces only geraniol from geranyl diphosphate.

6 e, Rv1086, adds one isoprene unit to omega,E-geranyl diphosphate.

7 , respectively, as their major products from geranyl diphosphate.

8 ated as a possible C-methyltransferase, with geranyl diphosphate (1) and S-adenosylmethionine gave th

9 Regiospecifically labeled geranyl diphosphates ((2E,6E)-[1,1,8,8,8-(2)H(5)]- and (

10 e the corresponding chlorinated analogues of geranyl diphosphate (3-ClGPP) and farnesyl diphosphate (

11 nzyme activity level (7-fold), and in planta geranyl diphosphate and geranylgeranyl diphosphate level

12 e overexpressed a bifunctional spruce IDS, a geranyl diphosphate and geranylgeranyl diphosphate synth

13 values of 21 and 51 microM were obtained for geranyl diphosphate and Mn2+, respectively.

14 Incubation of geranyl diphosphate and S-adenosylmethionine with a mixt

15 r isopentenyl diphosphate, 38 micrometer for geranyl diphosphate, and 16 micrometer for neryl diphosp

16 zyme was functionally expressed and produced geranyl diphosphate as its major product.

17 functional hybrid heterodimer that generated geranyl diphosphate as product in each case.

18 to all known monoterpene cyclases, which use geranyl diphosphate as substrate and invoke a cationic i

19 on in Escherichia coli and enzyme assay with geranyl diphosphate as substrate, subsequent analysis of

20 icate that, contrary to the textbook view of geranyl diphosphate as the "universal" substrate of mono

21 he monoterpene bornyl diphosphate (BPP) from geranyl diphosphate by BPP synthase using state of the a

22 Geranyl diphosphate C-methyltransferase (GPPMT) from Str

23 antly to beta-cubebene, while Mg17 converted geranyl diphosphate (C(5)) to alpha-terpineol.

24 in plants typically proceeds through either geranyl diphosphate (C10) or trans-farnesyl diphosphate

25 noid coupling reactions to give a mixture of geranyl diphosphate (chain elongation), chrysanthemyl di

26 mation of the prenyl diphosphate precursors, geranyl diphosphate, farnesyl diphosphate, and geranylge

27 phosphate synthase 1 (PcIDS1) yields 96% C10-geranyl diphosphate (GDP) and only 4% C15-farnesyl dipho

28 se in that it adds only one isoprene unit to geranyl diphosphate, generating the 15-carbon product (E

29 nd dimethylallyl diphosphate (DMAPP) to form geranyl diphosphate (GPP) and between IPP and GPP to giv

30 S1 catalyzing the irreversible conversion of geranyl diphosphate (GPP) to geraniol.

31 ed with dimethylallyl diphosphate (DMAPP) or geranyl diphosphate (GPP) to give the corresponding chlo

32 MoeN5 catalyzes the reaction of geranyl diphosphate (GPP) with the cis-farnesyl group in

33 is hypothesized to originate from 10-carbon geranyl diphosphate (GPP), 15-carbon farnesyl diphosphat

34 te (IPP), dimethylallyl diphosphate (DMAPP), geranyl diphosphate (GPP), farnesyl diphosphate (FPP), a

35 ere the C(10) product of the first addition, geranyl diphosphate (GPP), is the substrate for the seco

36 wers include three monoterpenes derived from geranyl diphosphate (GPP), myrcene, (E)-beta-ocimene and

37 (Humulus lupulus L.) trichomes, derives from geranyl diphosphate (GPP), the common precursor of monot

38 Geranyl diphosphate (GPP), the precursor of many monoter

39 Geranyl diphosphate (GPP), the precursor of most monoter

40 modifies an acyclic isoprenoid diphosphate, geranyl diphosphate (GPP), to yield a noncanonical acycl

41 imethylallyl diphosphate (DMAPP) and then to geranyl diphosphate (GPP).

42 th dimethylallyl diphosphate (DMAPP, C5) and geranyl diphosphate (GPP, C10) to give (E,E)-FPP (C15).

43 lly synthesized as stable analogs of omega,E-geranyl diphosphate in which the labile diphosphate moie

44 , myrcene and (E)-beta-ocimene, derived from geranyl diphosphate, in addition to a major phenylpropan

45 catalyzed the formation of 18O-geraniol from geranyl diphosphate, indicating that the reaction mechan

46 enchol synthase, plant cyclases that convert geranyl diphosphate into products with closely related b

47 The data from both organisms suggest that geranyl diphosphate is the allylic substrate for two dis

48 Geranyl diphosphate is the precursor of monoterpenes, a

49 the coupled isomerization and cyclization of geranyl diphosphate, is reported at 2.7-A; resolution in

50 for rat farnesyl diphosphate (FPP) synthase (geranyl-diphosphate:isopentenyl-diphosphate geranyltrans

51 s the addition of isopentenyl diphosphate to geranyl diphosphate, neryl diphosphate, omega,E,E-farnes

52 , except for a relatively low K(m) value for geranyl diphosphate of 0.2 microm.

53 dition of isopentenyl diphosphate to omega,E-geranyl diphosphate or omega,Z-neryl diphosphate yieldin

54 terminal domain catalyzes the cyclization of geranyl diphosphate, orienting and stabilizing multiple

55 FDS-1 prefers geranyl diphosphate over dimethylallyl diphosphate as an

56 r content of some compounds related with the geranyl-diphosphate pathway (neryl and geranyl acetates)

57 t cells overexpressing Rv1086 incubated with geranyl diphosphate showed a 5-fold increase of [(14)C]i

58 Geranyl diphosphate synthase (GPPS) catalyzes the conden

59 myrcene, in transgenic tobacco by elevating geranyl diphosphate synthase (GPS) activity.

60 phate synthase (SlDXS), Arabidopsis thaliana geranyl diphosphate synthase 1 (AtGPS) and Mentha x pipe

61 The relative levels of geranyl diphosphate synthase and farnesyl diphosphate sy

62 the hybrid possesses characteristics of both geranyl diphosphate synthase and geranylgeranyl diphosph

63 Geranyl diphosphate synthase belongs to a subgroup of pr

64 synthases; yet it is absolutely required for geranyl diphosphate synthase catalysis.

65 diphosphate synthase, which are homodimers, geranyl diphosphate synthase from Mentha is a heterotetr

66 phosphate pathway were overexpressed, and a geranyl diphosphate synthase from the plant Abies grandi

67 nd recombinant enzymes, thus confirming that geranyl diphosphate synthase is a heterodimer.

68 Immunogold labeling of geranyl diphosphate synthase occurred within secretory c

69 ate synthase 1 (AtGPS) and Mentha x piperita geranyl diphosphate synthase small subunit (MpGPS.SSU) o

70 These results indicate that the geranyl diphosphate synthase small subunit is capable of

71 expression in Escherichia coli of the Mentha geranyl diphosphate synthase small subunit with the phyl

72 l subunits of peppermint (Mentha x piperita) geranyl diphosphate synthase, spearmint (Mentha spicata)

73 Geranyl diphosphate synthase, which catalyzes the conden

74 sion of the two together produced functional geranyl diphosphate synthase.

75 sis suggested that the heterodimeric geranyl(geranyl)diphosphate synthase [G(G)PPS] is involved in my

76 ted L. x intermedia CINS (LiCINS), converted geranyl diphosphate (the linear monoterpene precursor) p

77 l diphosphate and isopentenyl diphosphate to geranyl diphosphate, the key precursor of monoterpene bi

78 proceed via an RR-dependent isomerization of geranyl diphosphate to 3S-linalyl diphosphate, as shown

79 terpene cyclase limonene synthase transforms geranyl diphosphate to a monocyclic olefin and constitut

80 ersion of the ubiquitous terpenoid precursor geranyl diphosphate to the iridoid loganic acid.

81 te; however, one truncated protein converted geranyl diphosphate to the monoterpene limonene.

82 ncapable of converting the natural substrate geranyl diphosphate, via the enzymatically formed tertia

83 ase (GES) activity, generating geraniol from geranyl diphosphate, was shown to be localized exclusive

84 additional product, the regular monoterpene geranyl diphosphate, when incubated with isopentenyl dip

85 e formation of 10 volatile monoterpenes from geranyl diphosphate, with 1,8-cineole predominating.