ライフサイエンスコーパス: geranylgeraniol

1 ghtly regulated by 25-hydroxycholesterol and geranylgeraniol.

2 97 and augmented by the nonsterol isoprenoid geranylgeraniol.

3 s, which can be chemically complemented with geranylgeraniol.

4 ells was p53-independent and was reversed by geranylgeraniol.

5 and is augmented by the nonsterol isoprenoid geranylgeraniol.

6 d by addition of HMG-CoA, mevalonic acid, or geranylgeraniol.

7 endence of LTP on the non-sterol isoprenoid, geranylgeraniol.

8 olesterol and nonsterol isoprenoids, such as geranylgeraniol.

9 , or the prenylation precursors farnesol and geranylgeraniol.

10 se of the protons of esters of phytol and of geranylgeraniol.

11 ranylated by labelling J774 cells with [(3)H]geranylgeraniol.

12 whereas alendronate activation is blocked by geranylgeraniol.

13 ol, and alendronate effects are prevented by geranylgeraniol.

14 tially by mevalonate and more effectively by geranylgeraniol.

15 tabolically labeled with [(3)H]F-OH or [(3)H]geranylgeraniol ([(3)H]GG-OH).

16 Similar plots for 1-phosphono-(E,E,E)-geranylgeraniol, a dead-end inhibitor for GGPP, gave a c

17 tutive activity of LXRalpha was inhibited by geranylgeraniol, a metabolite of mevalonic acid.

18 vastatin, but not clodronate, are blocked by geranylgeraniol, a precursor of geranylgeranyl diphospha

19 We conclude that geranylgeraniol acts specifically and quickly to affect

20 Time course studies show that geranylgeraniol acts within 5 min and at 2 different tim

21 nisomycin, a protein synthesis inhibitor, or geranylgeraniol, an intermediate in the cholesterol bios

22 itavastatin-induced apoptosis was blocked by geranylgeraniol and mevalonate, products of the HMGCR pa

23 tatin effects are prevented by mevalonate or geranylgeraniol, and alendronate effects are prevented b

24 orporation of exogenously provided farnesol, geranylgeraniol, and unnatural analogs of these isopreno

25 e certain sterols, oxysterols, farnesol, and geranylgeraniol, as well as the diphosphate derivatives

26 LTP are reversed by a 20-min treatment with geranylgeraniol but not by cholesterol.

27 This superinduction was reversed by geranylgeraniol, but not by farnesol, further confirming

28 rporation studies showed that mevalonate and geranylgeraniol, but not farnesol, released the lovastat

29 When added to lovastatin-treated cells, geranylgeraniol, but not farnesol, restored replication

30 also supplied with the 20-carbon isoprenoid geranylgeraniol, but not the 15-carbon farnesol, raising

31 adhesion was reversed by co-incubation with geranylgeraniol, but not with farnesol, with concurrent

32 This suggests that a diet containing geranylgeraniol can limit the anti-tumour activity of pi

33 that the oxysterol 25-hydroxycholesterol and geranylgeraniol combine to trigger extraction of reducta

34 Geranylgeraniol counteracts the antiaphrodisiac effect d

35 miriamin, characterized as a polyoxygenated geranylgeraniol derivative.

36 lesterol biosynthetic pathway, of which one, geranylgeraniol diphosphate, is required for learning in

37 s c were found to be farnesol esterified and geranylgeraniol esterified.

38 role of geranylgeranyl isoprenoids GGPP and geranylgeraniol (GGOH) in regulating Abeta production.

39 I as well as combinations of lovastatin with geranylgeraniol (GGOH) or farnesol (FOH) to investigate

40 ch utilizing a combination of lovastatin and geranylgeraniol (GGOH) to potentiate the ability of lova

41 Addition of geranylgeraniol (GGOL) in the presence of lovastatin, to

42 to sterols and to other products, including geranylgeraniol groups attached to proteins.

43 New fluorescent analogues of farnesol and geranylgeraniol have been prepared and then converted to

44 te pathway and that a constant production of geranylgeraniol in a small subset of neurons is required

45 lts identify UBIAD1 as the elusive target of geranylgeraniol in reductase degradation, the inhibition

46 Geranylgeraniol inhibits binding of UBIAD1 to reductase,

47 The requirement for geranylgeraniol is independent of acute protein isopreny

48 Shorter (C10, geraniol) and longer (C20, geranylgeraniol) isoprenols were inactive.

49 ls 50- and 22-28-kDa proteins, whereas [(3)H]geranylgeraniol labels only 22-28-kDa proteins.

50 ly related compound, does not substitute for geranylgeraniol nor does another animal model of impaire

51 tent with N-BP inhibition of isoprenylation, geranylgeraniol or farnesol prevented accumulation in S

52 renoids, such as nerolidol, cis-farnesol, or geranylgeraniol, or metabolites in the cholesterol pathw

53 nude mice were maintained on a diet lacking geranylgeraniol, oral pitavastatin caused regression of

54 , when the animal diet was supplemented with geranylgeraniol, pitavastatin failed to prevent tumour g

55 sterification of bacteriochlorophyllide a by geranylgeraniol-PPi during bacteriochlorophyll a biosynt

56 This inhibition is prevented by exogenous geranylgeraniol, probably required for prenylation of GT

57 lyalkenes, including geraniol, farnesol, and geranylgeraniol, providing an efficient and stereoselect

58 led with bacteriochlorophyll esterified with geranylgeraniol, rather than with phytol, implying that

59 AS9-mediated knockout of UBIAD1 relieves the geranylgeraniol requirement for reductase degradation.

60 eranyl acetate is progressively converted to geranylgeraniol then externalized.

61 splacement from reductase in the presence of geranylgeraniol, thereby preventing degradation of reduc

62 dation augmented by the nonsterol isoprenoid geranylgeraniol through an unknown mechanism.

63 Addition of geranylgeraniol to slices from 24-hydroxylase knockout m

64 Localized delivery of geranylgeraniol to the dendritic trees of CA1 hippocampa

65 farnesyl diphosphate synthase inhibitors or geranylgeraniol transferase I inhibitors, we evaluated c

66 ated activation is blocked by mevalonate and geranylgeraniol whereas alendronate activation is blocke

67 fully by mevalonate and less effectively by geranylgeraniol whereas alendronate effects are blocked

68 f bacteriochlorophyll (BChl) a, phytol, with geranylgeraniol, which possesses three more double bonds

69 The addition of geranylgeraniol, which restores geranylgeranylation, res