ライフサイエンスコーパス: geranylgeranylation

1 GTPase (membrane anchored via its C-terminal geranylgeranylation).

2 can be modified in vitro by farnesylation or geranylgeranylation.

3 lysine region are important determinants for geranylgeranylation.

4 ed, all other gamma subunits are modified by geranylgeranylation.

5 not due to failure of the mutant to undergo geranylgeranylation.

6 ), which is post-translationally modified by geranylgeranylation.

7 y provide valuable reagents to study protein geranylgeranylation.

8 ve DAF expression is negatively regulated by geranylgeranylation.

9 t affected by substituting farnesylation for geranylgeranylation.

10 vents seem to be downstream of inhibition of geranylgeranylation.

11 protein prenylation as shown by protein RhoA geranylgeranylation.

12 escribed Rho family proteins are modified by geranylgeranylation, a lipid attachment required for pro

13 lonate pathway, is the substrate for protein geranylgeranylation, a protein post-translational modifi

14 gh binding of Cdc42 to PLD1 does not require geranylgeranylation, activation of PLD1 is dependent on

15 Inhibition of its geranylgeranylation affords a therapeutic strategy for t

16 errogating biologies associated with protein geranylgeranylation and define a novel structure for thi

17 n of the TRQQKRP motif results in diminished geranylgeranylation and delocalization of intracellular

18 Lovastatin acted by inhibiting both geranylgeranylation and farnesylation, and not by alteri

19 esol pyrophosphate and thereby inhibits both geranylgeranylation and farnesylation.

20 talyzed farnesylation is 37-fold slower than geranylgeranylation and is limited by the farnesyl trans

21 Geranylgeranylation and membrane association of Rab27, a

22 ered with angiogenesis via inhibition of the geranylgeranylation and membrane localization of RhoA.

23 ough lovastatin, which inhibits both protein geranylgeranylation and protein farnesylation, blocked P

24 Our data indicate that inhibition of protein geranylgeranylation and RhoA pathways induce apoptosis i

25 The role of protein geranylgeranylation and the RhoA pathway in the regulati

26 ndent post-translational lipid modification (geranylgeranylation) and subsequent membrane association

27 ins simultaneously inhibit farnesylation and geranylgeranylation, and in consequence do not inhibit M

28 hich inhibits both protein farnesylation and geranylgeranylation, arrested cells in G0/G1 whereas cel

29 by geranylgeranyl pyrophosphate, implicating geranylgeranylation as a critical determinant of the sta

30 or tyrosine phosphorylation requires protein geranylgeranylation but not protein farnesylation and th

31 These results demonstrate that protein geranylgeranylation, but not farnesylation, is required

32 atin inhibits both protein farnesylation and geranylgeranylation by decreasing cellular pools of farn

33 ulation of iNOS by statins via inhibition of geranylgeranylation by GGTI-298, but not via inhibition

34 d with the C-terminal peptide of lamin B for geranylgeranylation by PGGT-I and for farnesylation by P

35 lation of leucine-ending CAAX substrates nor geranylgeranylation by the FTase is necessary for these

36 The selective inhibition of protein geranylgeranylation by the specific protein geranylgeran

37 ed by FTase to a level comparable to that of geranylgeranylation catalyzed by GGTase I.

38 In the absence of protein geranylgeranylation, compromised PI(3)K activity allows

39 phosphate, we demonstrate that the impact of geranylgeranylation depends on the fatty acid content of

40 In contrast, geranylgeranylation down-regulates MMP-1 expression.

41 Thus, inhibition of geranylgeranylation either directly through geranylgeran

42 Consistent with a role in geranylgeranylation, embryos deficient in geranylgeranyl

43 We found that protein geranylgeranylation enabled Toll-like receptor (TLR)-ind

44 Swapping geranylgeranylation for farnesylation on Ras proteins or

45 1 require post-translational modification by geranylgeranylation for full function.

46 rdial cell-autonomous requirement of Ggamma1 geranylgeranylation for heart formation and suggest the

47 Protein geranylgeranylation (GGylation) is an important biochemi

48 ontaining a C-terminal CAAX motif to promote geranylgeranylation (GRK6-GG).

49 ause we have shown that targeting Rab GTPase geranylgeranylation impairs monoclonal protein trafficki

50 hile 3-vinylgeranylgeraniol restores protein geranylgeranylation in cells.

51 sult calls into question the role of protein geranylgeranylation in inflammatory cell signaling.

52 been attributed to inhibition of RHO protein geranylgeranylation in inflammatory cells.

53 tional lipid modifications farnesylation and geranylgeranylation in protein localization and function

54 g perturbations in farnesylation rather than geranylgeranylation in synergistic interactions.

55 Rap 1A; the lack of Rap 1A processing beyond geranylgeranylation in the variant cells was not seconda

56 sults highlight a conserved role for protein geranylgeranylation in this context.

57 y we demonstrated that inhibition of protein geranylgeranylation inhibited phorbol ester-stimulated a

58 further mutated to undergo posttranslational geranylgeranylation is also more active, recovering most

59 Protein geranylgeranylation is critical for the function of a nu

60 Geranylgeranylation is critical to the function of sever

61 In this study, I show that the kinetics of geranylgeranylation is influenced by the nucleotide stat

62 Geranylgeranylation is initiated by formation of a stabl

63 This geranylgeranylation is required for their proper subcell

64 lational modification of the Rho proteins by geranylgeranylation is required for their subsequent act

65 Prenylation of protein (farnesylation and geranylgeranylation) is involved in several human cancer

66 n addition to bypassing FTI blockade through geranylgeranylation, K-Ras4B resistance to FTIs may also

67 H 3T3 and Rat-1 cells) inhibition of protein geranylgeranylation leads to a G0/G1 arrest, whereas inh

68 anylgeranylated and that inhibition of their geranylgeranylation mediates, at least in part, the effe

69 able which can distinguish farnesylation and geranylgeranylation modification in a single experimenta

70 ne) while showing little preference for CAAL geranylgeranylation motif substrates (where L represents

71 pene blocks an MEP pathway-dependent protein geranylgeranylation necessary for the signaling cascade.

72 nesol, further confirming that inhibition of geranylgeranylation, not farnesylation, is responsible f

73 In vitro geranylgeranylation of an Arabidopsis Rab1 protein conta

74 Geranylgeranylation of C17orf37 at the CAAX motif facili

75 he fluorescence enhancement that accompanies geranylgeranylation of dansyl-GCIIL.

76 FTase was also able to catalyze geranylgeranylation of GST-lHDAg at a very low rate, sug

77 y low rate, suggesting that the low level of geranylgeranylation of GST-lHDAg observed in cytosolic p

78 Geranylgeranylation of lHDAg expressed in COS cells was

79 bly of the viral replication complex require geranylgeranylation of one or more host proteins.

80 Geranylgeranylation of Rab GTPases is an essential post-

81 These findings indicate that geranylgeranylation of Rab GTPases is critical for hemos

82 an enzyme responsible for post-translational geranylgeranylation of Rab GTPases represents one way to

83 l blocked the ability of insulin to increase geranylgeranylation of Rab-4, whereas GGTI-298 and alpha

84 n cognate to Ras Gln-61.2) Posttranslational geranylgeranylation of Rab24, determined by metabolic la

85 Geranylgeranylation of Rabs is a complex reaction that r

86 where the inhibitors were shown to block the geranylgeranylation of Rap-1A without affecting the farn

87 geranyl pyrophosphate, the substrate for the geranylgeranylation of Rho, reversed the effect of simva

88 hibited by GGTI, a specific inhibitor of the geranylgeranylation of Rho; by C3 exotoxin, which inacti

89 Geranylgeranylation of RhoA small G-protein is essential

90 This leads to reduced geranylgeranylation of small GTPases such as Rho and Rac

91 e (100 micromol/L), suggesting inhibition of geranylgeranylation of target protein(s) as the predomin

92 -lowering drug that blocks farnesylation and geranylgeranylation of target proteins, increases LPS-in

93 n the sense that it is strongly inhibited by geranylgeranylation of the adjacent cysteine.

94 Geranylgeranylation of the fusion protein was also obser

95 senescence in NHOK is mediated, in part, via geranylgeranylation of the mevalonate pathway.

96 mma1 CaaX sequence (gamma1-S74L) resulted in geranylgeranylation of the resulting gamma1 subunit, and

97 An escort protein, Msi4p, was necessary for geranylgeranylation of Ypt1p by yeast PGGTase-II.

98 ies addressing which isoprenylation pathway--geranylgeranylation or farnesylation--is inhibited by si

99 pyrophosphate and mimicked by inhibiting Rho geranylgeranylation or Rho-kinase (ROCK).

100 her peptides are specific for farnesylation, geranylgeranylation, or dual prenylation.

101 e pharmacological shunting of K-Ras into the geranylgeranylation pathway promotes K-Ras association w

102 ut upstream of cholesterol, specifically the geranylgeranylation pathway.

103 ct on TGFbeta signaling by inhibition of the geranylgeranylation pathway.

104 hese results document that farnesylation and geranylgeranylation play differential roles in AD pathog

105 presence of lovastatin, to stimulate protein geranylgeranylation, prevented lovastatin's effects.

106 Furthermore, the geranylgeranylation rate constant is enhanced by the add

107 om dissociating from REP prior to the second geranylgeranylation reaction, ensuring efficient digeran

108 Third, we show that free REP inhibits the geranylgeranylation reaction, suggesting that the comple

109 Here, we studied the role of REP in the geranylgeranylation reaction.

110 However, the catalytic efficiencies of these geranylgeranylation reactions are between 15- and 140-fo

111 The isoprenoid donor for protein geranylgeranylation reactions, geranylgeranyl diphosphat

112 Statin treatment inhibiting Rac1 geranylgeranylation reduced 11beta-HSD2 up-regulation.

113 ermine whether protein prenylation (farnesyl/geranylgeranylation) regulates matrix metalloproteinase

114 g the therapeutic consequences of inhibiting geranylgeranylation relative to farnesylation.

115 Geranylgeranylation represents a novel mechanism by whic

116 addition of geranylgeraniol, which restores geranylgeranylation, rescued HUVEC from apoptosis.

117 selectively block protein farnesylation and geranylgeranylation, respectively.

118 Posttranslational geranylgeranylation selectively alters the lifecycle of

119 We propose that post-translational geranylgeranylation serves as a regulator of both RhoA a

120 1 or Sso2 proteins that have a COOH-terminal geranylgeranylation signal instead of a transmembrane do

121 fect resulted from the inhibition of protein geranylgeranylation subsequent to the depletion of meval

122 gin have higher levels of proteins requiring geranylgeranylation than arterial endothelial cells and

123 However, elevated geranylgeranylation was not Rab5a-specific since all the

124 gh the classical Rho GTPases are modified by geranylgeranylation, we found that a majority of the oth

125 potentiate the induced-inhibition of protein geranylgeranylation when used in a 3:1 HG:HN combination

126 synthesis, which blocks cytokinesis, and in geranylgeranylation, which interferes with progression t

127 up-regulate eNOS expression by blocking Rho geranylgeranylation, which is necessary for its membrane

128 ts as a highly specific inhibitor of protein geranylgeranylation, while 3-vinylgeranylgeraniol restor

129 Furthermore, inhibition of protein geranylgeranylation with GGTI-298 significantly induced