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1 antibody-like reagent against mycosis, wheat germ agglutinin (WGA) was linked to the effector Fc regi
4 ionship was found between calcium content in germ and steeping time used during nixtamalization proce
5 es of this enzyme, we used a cell-free wheat germ-based expression system in which mRNA encoding FERO
6 ays a novel and important role in primordial germ cell (PGC) development and that ephrinB1 (efnb1) is
9 sms of MRLs and their physiological roles in germ cell and neural development, oncogenic functions in
13 routine follow-up, 98% in the International Germ Cell Cancer Collaborative Group good prognosis grou
14 gulators that are enriched at the primordial germ cell cytoplasmic bridge to ensure its stability dur
19 ion by NRF1 and epigenetic modulation during germ cell development and unequivocally demonstrate a no
27 ptibility, consistent with failed primordial germ cell differentiation as an initiating step in oncog
30 onal TOPBP1 deletion during pachynema causes germ cell elimination associated with defective X chromo
31 ucing apical ES degeneration, which leads to germ cell exfoliation from the seminiferous epithelium.
33 These findings suggest that Nanos promotes germ cell fate by downregulating maternal RNAs and prote
36 XY iPSCs can be differentiated into the male germ cell lineage and functional sperm that can be used
39 itiate expression of mesoderm and primordial germ cell markers asymmetrically on the embryonic and ex
42 ptor, Trapped in endoderm 1 (Tre1), mediates germ cell polarization at the onset of active migration
43 Transcriptomic analyses of these successive germ cell subtypes reveals dynamic transcription of over
45 re, we focus on the mechanisms that regulate germ cell survival during embryonic development in Droso
46 s who were 17 years or older, diagnosed with germ cell testicular cancer, and previously treated with
49 Purpose Patients with relapsed metastatic germ cell tumor (GCT) can be cured with second-line and
50 enome-wide association studies of testicular germ cell tumor (TGCT; 3,558 cases and 13,970 controls)
51 scents with intermediate-risk (IR) malignant germ cell tumors (MGCT) if the administration of cisplat
52 nderstanding of susceptibility to testicular germ cell tumors (TGCTs), but much of the heritability r
56 wide spectrum of human neoplasms, including germ cell tumors, high-grade and low-grade carcinomas an
59 platin and carboplatin are used primarily in germ cell, breast and lung malignancies, oxaliplatin is
60 ipt levels in several tumor tissues, such as germ cell, breast, and ovarian tumors, with in the latte
61 (c.1297_8ins353, p.K433Rins31*) in the male germ cell-associated kinase (MAK) gene (39% of families
62 lies like Drosophila, the ancestral receptor germ cell-expressed (gce) gene has duplicated to yield t
66 ly reported ChIP-seq datasets for primordial germ cell-like cells and E18.5 small intestine, combined
67 timulated by retinoic acid gene 8 (Stra8), a germ cell-specific gene activated during meiotic commitm
68 (TSTRs) and associated with highly expressed germ cell-specific genes and histone retention in mature
75 tem cells (ESCs) and gonad-derived embryonic germ cells (EGCs) represent two classic types of pluripo
76 e dysgenetic areas, with more ectopic SC and germ cells (GC) than DBP-FW treatment; DBP-LW induces no
81 ave profiled the transcriptome of primordial germ cells (PGCs) lacking the nanos homologs nos-1 and n
82 omatin modifications occur in the primordial germ cells (PGCs) of emergent starved L1 larvae that cor
83 the translational activity in the primordial germ cells (PGCs) of the sea urchin embryo (Strongylocen
84 1 is required for the survival of primordial germ cells (PGCs), as well as the suppression of germ ce
90 ession pattern that is primary restricted to germ cells and aberrantly reactivated in various cancers
91 (CTCF&BORIS) or BORIS alone (BORIS-only) in germ cells and in BORIS-positive somatic cancer cells.
92 ritable L1 insertions may therefore arise in germ cells and in pluripotent embryonic cells, prior to
94 ed to support cell adhesion and transport of germ cells and organelles (e.g., residual bodies, phagos
96 condensate (CSC) causes molecular defects in germ cells and phenotypic effects in their offspring.
97 ialized region of the oocyte that prefigures germ cells and specifies the germline of descendants in
98 ombinant human GDF9 and BMP15, these meiotic germ cells are further induced to form ovarian FLCs, inc
99 f two modes: a likely ancestral mode wherein germ cells are induced during embryogenesis by cell-cell
100 oocyte to embryo, genetic programs in mouse germ cells are reshaped by chromatin remodeling to orche
101 ich the fittest, strongest, or least damaged germ cells are selected for transmission to the next gen
102 g (induction) or a derived mechanism whereby germ cells are specified by using germ plasm-that is, ma
104 impaired LAP-mediated clearance of apoptotic germ cells as miR-471-5p transgenic mice show lower leve
106 cells interact with and regulate primordial germ cells by actively excising and digesting germ cell
107 P.Although phagocytic clearance of apoptotic germ cells by Sertoli cells is essential for spermatogen
109 sential for efficient clearance of apoptotic germ cells by Sertoli cells using LAP.Although phagocyti
113 enesis, a process through which haploid male germ cells differentiate into spermatozoa, represents an
114 events that characterize the development of germ cells during fetal life as they commit to, and prep
115 ent, Arf-null mice are blind, and their male germ cells exhibit defects in meiotic maturation and spe
116 piRNA-deficient mice, L1-overexpressing male germ cells exhibit excessive DNA damage and meiotic defe
121 ly, DPY-21 also associates with autosomes of germ cells in a DCC-independent manner to enrich H4K20me
125 developmental accumulation of proliferative germ cells in the C. elegans hermaphrodite is sensitive
126 verexpression rescues clearance of apoptotic germ cells in the testes of Mertk (-/-) mice it fails to
127 adotropes of the pituitary and in Leydig and germ cells in the testes, but at very low levels in Sert
129 ine (Aub) maintains genome integrity in late germ cells of the Drosophila ovary through Piwi-associat
131 unctions, and speculates as to why mammalian germ cells require expression of three AURKs instead of
136 data suggest that E(z) acts intrinsically in germ cells to activate dedifferentiation and thus replen
138 roalgal life cycles - from the production of germ cells to the growth and fertility of the adult orga
139 rgeted and reversible ablation of premeiotic germ cells undergoing differentiation into oocytes in tr
144 at SMG-1 mainly acts in mitotically dividing germ cells, and during late embryonic and larval develop
147 A-binding proteins specifically expressed in germ cells, DAZL and BOULE, regulate the exit from pluri
148 7 exhibits male-specific expression in early germ cells, germline stem cells and spermatogonia in ins
149 em cell differentiation into late primordial germ cells, meiotic germ cells and ovarian follicles.
150 lean switch from mitosis to meiosis in mouse germ cells, revealing a conserved role for YTHDC2 in thi
151 compartment, which surrounds the nucleus of germ cells, suggesting that sequestration of RNA to this
153 genetic features of closed chromatin in male germ cells, which suggests that CNVs may repress recombi
163 associated with hypoadenylated mRNAs (e.g., germ cells/neurons) and/or limiting cytoplasmic PABP (e.
165 This research studied the influence of the germ components on the physicochemical properties of coo
166 ents an intermediate between short- and long-germ development, ideal for comparative study of PRGs.
168 st blocks to both Escherichia coli and wheat germ extract translation systems, whereas N2-methylguano
170 tributes to tumor distribution, we generated germ-free (GF) Apc(Min/+) and Apc(Min/+) ;Il10(-/-) mice
171 crobiota in specific pathogen-free (SPF) and germ-free (GF) mice given more than 40 unique diets; we
172 typically, and functionally compared between germ-free (GF), specific pathogen-free, and GF mice reco
175 ective role was observed in conventional and germ-free animal facilities, indicating that it does not
176 ystem, with for example the observation that germ-free animals harbor a poorly developed intestinal i
180 st variation in colonization when individual germ-free flies were fed their own natural commensals (i
181 on tissue sections from immunocompromised or germ-free hosts, chronically infected hosts where the ti
184 llus reuteri This species induced DP IELs in germ-free mice and conventionally-raised mice lacking th
185 duced mechanical hyperalgesia was reduced in germ-free mice and in mice pretreated with antibiotics.
190 ith a favorable gut microbiome as well as in germ-free mice receiving fecal transplants from respondi
191 er, in vivo administration of NOD1 ligand to germ-free mice restored the numbers of hematopoietic ste
192 s or mice (IBD, metabolic syndrome, etc.) to germ-free mice was found to be sufficient to transfer so
196 hted by anatomical and functional changes in germ-free mice, affecting the gut epithelium, immune sys
197 diabetic mice; when transferred to recipient germ-free mice, oral microbiota from IL-17-treated donor
198 ve effects were lost in both Ifnar1(-/-) and germ-free mice, revealing essential roles for type I int
199 al bacterial composition and, by transfer to germ-free mice, that the oral microbiota of diabetic mic
200 ensal colonization in antibiotic-treated and germ-free mice, using cultured commensals from the Actin
206 ed in specific-pathogen-free conditions into germ-free Nlrp12-deficient mice showed that NLRP12 and t
207 m cancer patients who responded to ICIs into germ-free or antibiotic-treated mice ameliorated the ant
208 gnificant decrease in serum triglycerides in germ-free rats fed a high sugar diet compared to convent
211 ferences in the number of secretory cells in germ-free zebrafish and their conventional counterparts,
212 erved a broad convergence of interactions of germ granule and P body mRNP components on AIN-1/GW182 a
215 and identify a functional continuum between germ granules and P bodies in the C. elegans embryo.
218 degree of mineralization of permanent tooth germs in dental age assessment has been an area of inter
219 ptome of small groups of cells from a single germ layer and to retain spatial information, dorsal and
222 e critical molecular signaling inputs during germ layer specification in bilaterian metazoans, but th
226 b-group proteins, which coordinate embryonic germ-layer formation in response to extraembryonic cues.
227 Overall, these results lead to a model of germ-layer formation in which, upon N-cadherin expressio
230 n, the relative mRNA expression in the three germ layers and the trophoblast was abnormal in the EBs
232 rived organoids with components of all three germ layers have been generated, resulting in the establ
233 iotemporal pattern of gene expression across germ layers provides evidence that the endoderm was the
234 eposited as pillars between widely separated germ layers, namely the somitic mesoderm and the endoder
236 CH1/FBXW7 (N/F) mutations and RAS/PTEN (R/P) germ line (GL) were classified as oncogenetic low risk (
237 l IgE production was quantified with epsilon germ line (IGHE) transcripts and correlated with serum I
242 ble analyses of the role of Cdk5 in GVHD, as germ line Cdk5 gene deletion is embryonically lethal.
243 e MAGE gene family that is expressed in male germ line cells and placenta under normal physiological
244 rprisingly, dramatically affected by the non germ line encoded portions of CDR3 of the T cell recepto
245 te the antiquity of some, and possibly most, germ line HHV-6 integrations, the majority of ciHHV-6B (
246 ere able to assign a causal or likely causal germ line mutation in 86 patients (48.0%), involving a t
248 or ETAA1 in this process by surveying random germ line mutations in mice using exome sequencing and b
253 Here, we show that knockdown of Hop in the germ line nurse cells (GLKD) of Drosophila ovaries leads
256 o the accumulation of gamma-H2Av foci in the germ line, indicating increased DNA damage in the ovary.
257 cific AHA-variable regions were mutated from germ line-derived sequences and displayed a high sequenc
258 teracting RNAs (piRNAs) are 26-30-nucleotide germ line-specific small non-coding RNAs that have evolu
259 ous isoform in all tissues (LIG3alpha) and a germ line-specific splicing isoform (LIG3beta) that diff
266 nd mutations during affinity maturation, the germ-line IG loci are also diverse across human populati
267 iments with purified recombinant iPLA2gamma, germ-line iPLA2gamma(-/-) mice, cardiac myocyte-specific
276 ng with diploid spermatogonia, which include germ-line stem cells, and ending with haploid spermatozo
277 roach that enables us to model the effect of germ-line variation on tissue-specific gene expression i
278 rimordial germ cells (PGCs) give rise to the germ lines, the cell lineages that produce sperm and egg
279 n chronological age and the formation of the germ of the second lower premolar (r=0.67; p<0.001).
280 of non-transgenic corn and their fractions (germ, pericarp, endosperm, cornmeal and grits), collecte
281 that could explain the repeated evolution of germ plasm and propose potential consequences of the inh
282 , whereby Tahre retroelements traffic to the germ plasm by mimicking oskar RNAs and engaging the Stau
283 as been hypothesized that the acquisition of germ plasm confers enhanced evolvability, resulting from
286 in germ plasm inheritance, such that higher germ plasm inheritance correlates with higher primordial
287 rocess linked to quantitative differences in germ plasm inheritance, such that higher germ plasm inhe
291 e classes of retrotransposons migrate to the germ plasm, a specialized region of the oocyte that pref
292 s, and resulting in high speciation rates in germ plasm-containing lineages (denoted herein as the "P
293 sm whereby germ cells are specified by using germ plasm-that is, maternally specified germ-line deter
294 ed that calcium carbonate is formed into the germ structure to 2.1 w/w of calcium hydroxide and 9h st
296 morphology, characterized by emergence of a germ tube from the yeast cell followed by mold-like grow
297 es pombe Germinating spores develop a single germ tube that emerges from the outer spore wall in a pr
299 pmental arrest of the mandibular molar tooth germs while their maxillary molar tooth germs completed
300 nogaster Whereas Drosophila embryos are long-germ, with segments specified more or less simultaneousl
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